DOCSLIB.ORG

Appendix the Henderson Memorial Lectures

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Appendix the Henderson Memorial Lectures Appendix The Henderson Memorial Lectures The Henderson Memorial Lectures were initiated by Dr R. J. C. Harris in 1976, in com- memoration of David W. W. Henderson, the first Director of the establishment. Lectures have been held in most years since this date, usually on a topic of interest to the research of the Centre and always by someone eminent in the field. The lecture is marked by the award of the Henderson Memorial Medal, struck by the Gaunt Mint in Birmingham in sterling silver. During the MOD and PHLS eras, the medal bore the establishment logo on the obverse. In 1994, this was replaced with a likeness of Henderson himself, taken from a photograph of the portrait of him which hangs in CAMR. The following is a comprehensive list of Memorial lecturers and, where known, the titles of their lectures. 1975 Prof. D. G. Evans (Director, National Institute for Biological Standards) 1976 Prof. D. A. L. Davies 1977 Not held 1978 Prof. J. M. Ashworth (Chief Scientist, Central Policy Review Staff, Cabinet Office) The Cellular Slime Moulds: Microbial Differentiation 1979 Sir Hans Kornberg (Department of Biochemistry, University of Cambridge) The Importance of Being Microbiological (in the Study of Metabolic Regulation) 1980 Not held 1981 Prof. J. Postgate FRS (Director, Agricultural Research Council, Unit of Nitrogen Fixation, University of Sussex) A Fixation About Nitrogen 1982 Dr D. A. J. Tyrrell FRS (Clinical Research Centre, Division of Communicable Diseases, Harrow) Pros and Cons of Doing Research on Human Beings 1983 Prof. Henry Harris FRS (Regius Professor of Medicine, Sir William Dunn School of Pathology, Oxford) A New Marker for Human Malignant Cells 1984 Dr Sidney Brenner FRS (The MRC Laboratory of Molecular Biology, Cambridge) Analysing Biological Complexity 1985 Dr Cesar Milstein FRS (MRC Laboratory of Molecular Biology, Cambridge) Dissecting the Immune Response 1986 Prof. M. A. Epstein CBE, FRS (Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford) The Prevention of Epstein-Barr Virus-Associated Cancers 1987 Sir Walter Bodmer FRS (Director of Research, Imperial Cancer Research Fund) Genes, Viruses and Cancer 1988 Prof. Luc Montagnier (Head of Viral Oncology, Institut Pasteur, Paris) HIV in AIDS Pathogenesis 1989 Dr C. E. Gordon Smith (Director of MRE 1964–71; former Dean, London School of Hygiene and Tropical Medicine) Microbiological War and Peace – Porton Revisited 1990 Not held 1991 Not held 1992 Prof. B. S. Hartley (Emeritus Professor of Biochemistry, Imperial College) The Weak-point in Thermostability of Glucose Isomerases 1993 Not held 236 Appendix 237 1994 Prof J. Oliver Dolly (Prof. of Biochemistry, Imperial College) Toxins, Twitches and Transmitter Release: Discovery of Participating Proteins 1995 Prof. Robert Steffen (Institute of Preventive Medicine, University of Zurich) Travel Medicine: the Risks and the Role of Vaccines 1996 Dr Brian W. J. Mahy (Director of the Division of Viral and Rickettsial Diseases, the National Center for Infectious Diseases, CDC, Atlanta) Why are Viral Diseases Emerging and Re-emerging? 1997 Dr Chris Evans (Founder and Director, Merlin Ventures) Creating Business and Wealth from Science and Technology 1998 Not held 1999 Not held 2000 Not held Notes Chapter 2: Early Beginnings 1. See: Stone J. F. S. (1958). Wessex Before the Celts. Thames & Hudson, London. 2. For further information, see Wells T. C. E., Sheail J., Ball D. F. and Ward L. K. J. (1976). ‘Ecological studies on the Porton Ranges: relationships between vegetation, soils and land-use history’. J. Ecology 64, 589–626. 3. Harris S. H. (1994). Factories of Death; Japanese Biological Warfare 1932–1945 and the American Cover-up. Routledge, London. See also: Williams P. and Wallace D. (1989). Unit 731: The Japanese Army’s Secret of Secrets. Hodder & Stoughton, London. 4. Editorial: ‘Rhodesians used Biological Weapons’. New African, September 1992, p. 42. 5. Wickham Steed H. (1934). ‘Aerial Warfare: Secret German Plans’. The Nineteenth Century and After 116, 1–15. 6. Wickham Steed H. (1934). ‘The Future of Warfare’. The Nineteenth Century and After 116, 129–40. 7. CID COS Sub-Committee: Minutes of the 118th Meeting, held on 12 February 1934. PRO CAB 53/4. 8. Composition: Col. Sir Maurice Hankey (Chairman); Surg. Rear Admiral S. F. Dudley (Deputy Med. Dir. General, Navy); Lt Gen. Sir J. A. Hartigan (Dir. General, Army Medical Services); Air Vice Marshall A. W. Iredell (Dir. RAF Medical Services); Maj. S. Blackmore (Medical Adviser, ARP Dept. of the Home Office); N. K. Johnson (Chief Superintendent, Chemical Defence Research Dept.); Dr D. E. Mellanby (Secretary, MRC); Prof. J. C. G. Ledingham (MRC); Dr B. A. Keen (Rothamsted Experimental Station); Prof. W. W. C. Topley (London School of Hygiene and Tropical Medicine); Wing Cdr P. Warburton (Committee of Imperial Defence); F. Hemming (Economic Advisory Committee). Details are given in PRO WO188/650. 9. CBW1 CID Sub-Committee on BW; 2 November 1936. PRO WO188/650. 10. CBW2 CID Sub-Committee on BW; 4 November 1936. PRO WO188/650; CBW3 CID Sub-Committee on BW; 4 November 1936. PRO WO188/650; CBW12 CID Sub- Committee on BW; 22 February 1937. PRO WO188/650. 11. CBW Sub-Committee on BW First Report; 25 October 1937. PRO WO 188/650. 12. Ibid. 13. Ibid. 14. Williams R. E. O. (1985). Microbiology for the Public Health. PHLS, London, pp. 163–4. 15. A three-volume history on Hankey’s life has been written by Roskill S. (1970, 1972, 1974). Hankey: Man of Secrets. Collins, London. 16. Who arrived first is not known, but it is known that Gladstone, Packman and Morris drove, in Gladstone’s car, to Porton on 5 October 1940. It is believed that Fildes, Henderson and Thackeray had arrived a few days earlier; Woods and Hill arrived at a later date. 17. Pasquill F., Sheppard P. A. and Sutcliffe R. C. (1978). Oliver Graham Sutton: 4 February 1903 – 26 May 1977. Biographical Memoirs of Fellows of the Royal Society 24, 529–46. 18. See Carter G. B. (2000). Chemical and Biological Defence at Porton Down 1916–2000. The Stationery Office, London, pp. 63–4. 238 Notes 239 19. Harris R. and Paxman J. (1982). A Higher Form of Killing. Chatto & Windus, London, pp. 90–1. 20. Murphy S., Hay A. and Rose S. (1984). No Fire No Thunder: The Threat of Chemical and Biological Weapons. Pluto Press, London, p. 31. 21. Garrett, B. ‘The CW Almanac: April 1996’. ASA Newsletter 96–3, p. 9. 22. Carter, G. B. The Legend of Fildes and the Heydrich Assassination. ASA Newsletter 96–4, p. 8. 23. Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous or other Gases, and of Bacteriological Methods of Warfare; Geneva 17 June 1925. Ratified by the UK on 9 April 1930. 24. Medical Research in War: Report of the MRC for the Years 1939–45. Cmd. 7335. HMSO. Chapter 3: Sea Trials 1. Trials took place over 1948–49: Brucella abortus: five trials: two on 9 December, two on 11 December and one on 16 December Bacillus subtilis: one trial: 16 December Bacillus anthracis: 26 January (4lb bomb trial); 27 January (two head spray trial); 5 February (4lb bomb trial); 6 February (spray trial) Brucella suis: 21 December (spray trial); 22 December (spray trial); 7 January (spray trial); 9 January (two spray trials); 22 February (two 4lb bomb trials) Bacterium tularense: 5 February (4lb bomb trial); 5 February (spray trial); 24 February (two 4lb bomb trials); 25 February (4lb bomb trial) 2. The pontoon was a 200 × 60 feet spud pontoon from a Second World War Mulberry harbour, that is, a small floating island. 3. Vaccinia is the agent used to produce a smallpox vaccine. It has only a low level of pathogenicity and has therefore been used as a simulant for smallpox. At the time of the sea trials and beyond, there was a high level of vaccination amongst the global population for smallpox and its status as an effective BW agent at that time must be questioned. In present times vaccination has been discontinued fol- lowing eradication of the disease. This must lead, therefore, to a higher vulnera- bility. There are now only two countries authorized by the World Health Organisation to hold smallpox stocks, the USA and Russia, so the likely threat must be considered low. Chapter 4: Field Trials 1. Much of the work described in this chapter is reported in the MRE Field Trial Reports. Numbers 1–3 are in the PRO. Numbers 4–24 were first released by the MOD to public libraries in Dorset in May 1998. Most of these are now also in the PRO. 2. Cole L. A. (1990). Clouds of Secrecy: The Army’s Germ Warfare Tests Over Populated Areas, Rowman & Littlefield, Maryland, USA, pp. 46–8 and 60–5. 240 Notes 3. Toxicological Assessment of the Army’s zinc cadmium sulphide dispersion tests. National Academy Press, Washington DC, USA. (1997). 4. An arbitrary line sometimes used by geographers to divide the UK, drawn from the River Tees in the north-east to the River Exe in the south-west. 5. Travel of bacterial aerosol simulants over distances up to 15 miles. MRE Field Trial Report 1. 6. Concentration, viability and immunological properties of airborne bacteria released from a massive line source. MRE Field Trial Report 3. 7. The viability, concentration and immunological properties of airborne bacteria released from a massive line source. MRE Field Trial Report 4. 8. Comparison of the Viability of Escherichia coli in Airborne Particles and on Microthreads Exposed in the Field. MRE Field Trial Report 5. 9. May K. R. & Druett H. A. (1968). ‘A microthread technique for studying the viability of microbes in a simulated airborne state’. J. General Microbiology 51, 353–66.
Load more

Recommended publications
  • Reviews ~-Medical Journal Books Received
    JUNEJUNE24,L'+,1961 REVIEWS REVIEWS BRITISH 1813 ~-MEDICAL JOURNAL under the Presidency of Sir Charles Dodds. It was the Th2e Medical Register I96I. Parts 1 and 2. (Pp. 3,111 +xxiv.) first joint meeting between the British Society of London: The General Medical Council, 44 Hallam Street, W.i. Enclocrinology and the societies representing the Acta 1961. A Prelude to Medical History. By Felix Marti-lbifiez, Endocrinologica Congresses. M.D. (Pp. 253 +xix. $5.75.) New York: MD Publications, About two-thirds of the papers reported are included Inc. 1961. in four symposia. The first three, on " Neuroendo- The Mantagement ofPediatric Practice. By Hugh C. Thompson, crinology," " Thyroid Gland," and " Parathyroid M.D., and Joseph B. Seagle, M.S., M.D. (Pp. 172+xv; illUs- CGlands," make up Volume 9 (Part I). Volume 10 trated. 60s.) Springfield, Illinois: Charles C. Thomas. Oxford: (Part I1) includes the fourth symposium entitled "Are Blackwell Scientific Publications. 1961. the Endocrine Glands directly related to Cancer ? Par-ents of the Handicapped. Self. Organied Parents' adl Re!atives' Groutps for Treatmenzt of Ill anzd Hanydicappced and the remaining papers grouped under the headings Children. By Alfred H. Katz, D.S.W. (Pp. 155+ix. 48s.) " Steroid Biochemistry " and " Biological Actions and Springfield, Illinois: Charles C. Thomas. Oxford: Blackwell Interrelationships of Steroids and other Hormones." Scientific Publications. 1961. The symposia deal mainly with growing points and Thought Refo.rm and the Psychology, of Totalism. A Study oj give a representative picture of recent European "Brainwashing" in China. By Robert Lifton, M.D. (Pp. 510 achievements in these sectors of endocrinology.
    [Show full text]
  • The Worshipful Society of Apothecaries of London Galen Medal Winners
    The Worshipful Society of Apothecaries of London Galen Medal Winners 1926 Prof WE DIXON, BSc, MA, MD, DPH, FRS Pharmacology 1927 Sir Gowland HOPKINS, MA, LLD, DSc, FRCP, FRIC, FRS Discovery of vitamins 1928 Prof JJ ABEL, MD, ScD, LLD Isolation of Adrenaline 1930 Prof E FOURNEAU, Directeur de 1'Institute Pasteur Pharmacology of amino-alcohols 1932 Sir Henry DALE, OM, GBE, MA, MD, FRCP, FRS Neurophysiology 1934 Prof Sir Frederick BANTING, MC, Hon FRCS, DSc, LLD Discovery of Insulin 1946 Sir Alexander FLEMING, FRCP, FRCS, FRS Penicillin Lord FLOREY, MA, MD, FRCP, FRS 1947 F CURD, BSc, PhD D DAVEY, MSc, PhD Discovery of Paludrine F ROSE, BSc, PhD 1948 Sir Lionel WHITBY, CVO, MC, MD, FRCP Sulphonamides 1949 Prof J TREFOUEL, Directeur de 1'Institute Pasteur Sulphonamides 1951 Prof Sir Charles DODDS, Bt, MVO, MD, FRCP, FRS Biochemistry 1953 Sir Charles HARINGTON, MA, PhD, FRS Synthesised Thyroxin 1954 EL SMITH, DSc, FRIC Vitamin B12 1955 Lord BROCK, MS, FRCS Cardiac surgery 1957 Prof Sir Ernst CHAIN, MA, DPhil, FRS Production of Penicillin 1958 Sir Macfarlane BURNET, OM, MD, FRCP, FRS Vaccines for virus infections 1959 Prof Sir Bradford HILL, CBE, PhD, DSc, FRS Medical statistics 1960 Sir Tudor THOMAS, DSc, MD, MS, FRCS Corneo-plastic surgery 1961 Prof R PATERSON, CBE, MC, MD, FRCS, FFR Radiotherapy 1962 Prof W PENFIELD, OM, CMG, MD, DSc, FRS Neurosurgery & Neurophysiology 1963 Prof Sir Alexander HADDOW, MD, DSc, PhD, FRS Experimental pathology & cancer research 1964 FP DOYLE, MSc, FRIC Chemical & biological GN ROLINSON, BSc, PhD development
    [Show full text]
  • Drug Discovery: a History
    ________________________________________________________________________________________________________________________ ______________________________ Drug Discovery A History Walter Sneader School of Pharmacy University of Strathclyde, Glasgow, UK ________________________________________________________________________________________________________________________ ______________________________ Drug Discovery ________________________________________________________________________________________________________________________ ______________________________ Drug Discovery A History Walter Sneader School of Pharmacy University of Strathclyde, Glasgow, UK Copyright u 2005 John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England Telephone (+44) 1243 779777 Email (for orders and customer service enquiries): [email protected] All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patents Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. Requests to the Publisher should be addressed to the Permissions Department, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England, or emailed to [email protected], or faxed to (+44) 1243
    [Show full text]
  • Clinical Research in Britain 1950–1980
    Wellcome Witnesses to Twentieth Century Medicine CLINICAL RESEARCH IN BRITAIN 1950–1980 A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 June 1998 Witness Seminar Transcript edited by L A Reynolds and E M Tansey Introduction by David Gordon Volume 7 – September 2000 CONTENTS Introduction David Gordon i Witness Seminars: Meetings and publications iii Transcript 1 Index 67 INTRODUCTION The British, it is said, are not revolutionary by nature. However, in the last century, we created two organizations that have revolutionized the possibility and reality of clinical research, with worldwide influence. The first was the formation of the Medical Research Council (MRC). The Medical Research Council was the successor of the Medical Research Committee, appointed in 1913 to administer funds provided under the National Health Insurance Act of 1911 (see note 49). While there may be doubt whether or not these funds were intended primarily for research into tuberculosis or for medical research more generally, we cannot doubt the boldness of the step. A government set aside money for medical research, rather than devoting the funds available for a medical problem solely to prevention, diagnosis and treatment. The second revolutionary step was the creation of the National Health Service. The National Health Service Act of 1946 gave Ministers powers not only to conduct research, but also to support the research work of others. The notion of a population- wide, compre h e n s i ve healthcare system, free to the patient at the point of consultation, and able to support the clinical infrastructure of research, was truly revolutionary, and might have been impossible were it not for the appetite for social change created by the Second World War.
    [Show full text]
  • Long-Term Consequences of Prenatal Exposure Dolores Ibarreta and Shanna H
    84 Late lessons from early warnings: the precautionary principle 1896–2000 8. The DES story: long-term consequences of prenatal exposure Dolores Ibarreta and Shanna H. Swan 8.1. Introduction) secondary characteristics in both males and females. In 1938, Charles Dodds and In 1970, Herbst and colleagues reported an colleagues formulated DES, the first orally unprecedented finding; they had diagnosed active synthetic oestrogen (Dodds et al., a rare vaginal cancer (vaginal clear-cell 1938). This synthetic (non-steroidal) adenocarcinoma) in seven young women, a oestrogen has been estimated to be five times cancer that had never before been seen in as potent as oestradiol, the most potent this age group in this hospital (Herbst and naturally occurring oestrogen in mammals Scully, 1970). The following year, these (Noller and Fish, 1974). DES is inexpensive authors published the startling finding that and simple to synthesise and the developing seven of the eight cases (one more had been pharmaceutical industry quickly began identified), but none of 32 matched controls, worldwide production; DES was marketed had been prenatally exposed to the synthetic under more than 200 brand names. Like oestrogen diethylstilboestrol (DES) (Herbst other pharmaceuticals produced at that time, et al., 1971). Seven months after this DES underwent very limited toxicological publication, the US Food and Drug investigations. It rapidly became popular in a Administration (FDA) withdrew approval for wide variety of treatments, including those use of DES by pregnant women, for whom for menopausal symptoms and prostate this potent synthetic oestrogen had been cancer. Other therapeutic uses were prescribed since 1947 in the mistaken, but suppression of lactation, post-coital widespread, belief that it prevented contraception (morning-after pill) and post- spontaneous abortion (miscarriage).
    [Show full text]
  • Register of Returned Soldiers Land Holdings 1916-1930 Archives NZ Reference ACGT 18460 LS34/1
    Pandora Research www.nzpictures.co.nz Register of returned soldiers land holdings 1916-1930 Archives NZ Reference ACGT 18460 LS34/1 This is an index to a register of land holdings allotted to returned soldiers from the World War One New Zealand Expeditionary Force. The register is divided into four parts and arranged by province. [1] Land allotted to discharged soldiers without competition or by ballot under the Discharged Soldiers Settlement Act 1915 [2] Land acquired ordinarily or at auction by members of the New Zealand Expeditionary Force [3] Land acquired by ballot or at auction by discharged or returned soldiers [4] Land transferred to soldiers The register gives the file number, regimental number of the soldier, location and acreage of the land, class of land tenure granted, sale plan number, capital value, the amount of rent and the date of Land Board approval and remarks. Entries are listed across two pages – this is an example of a first page And the second page Last updated 04 June 2018 Page 1 of 49 Pandora Research www.nzpictures.co.nz Index Name Folio Name Folio Frank George Ackerman 21 Fred Charles Ammor 413 David Adair 463 Thomas Ammor 11 Albert Henry Adams 208 Les Vivian Amos 28 Bernard Joseph Adams 463 Sydney Herbert Amyes 44 Cecil John Adams 9 Andrew Anderson 28 Edward Adams 154 Bruce Anderson 20 John Adams 239 Charles Anderson 114 Maxwell Pears Adams 453 Charles Anderson 118 Thomas Adams 44 David B. Anderson 455 Walter John Adams 500 E. G. Anderson 301 William Richard Adams 463 Frederick William Anderson 128 Frederick George Adamson 451 George Oswald Anderson 43 John Quin Adamson 237 Leicester Conway Anderson 209 E.
    [Show full text]
  • Prenatal Exposure to Bisphenols and Cognitive Function in Children at 7Â
    Environment International 150 (2021) 106433 Contents lists available at ScienceDirect Environment International journal homepage: www.elsevier.com/locate/envint Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study Carl-Gustaf Bornehag a,b,*, Elin Engdahl c, Maria Unenge Hallerback¨ a, Sverre Wikstrom¨ d, Christian Lindh e, Jo¨elle Rüegg c,a, Eva Tanner b, Chris Gennings b a Karlstad University, Karlstad, Sweden b Icahn School of Medicine at Mount Sinai, New York City, USA c Uppsala University, Uppsala, Sweden d ¨ ¨ Orebro University, Orebro, Sweden e Lund University, Lund, Sweden ARTICLE INFO ABSTRACT Handling editor: Martí Nadal Background: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently intro­ duced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is Keywords: needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental Bisphenols outcomes in humans. BPA Objective: The present study aimed at examining the individual associations between prenatal BPA, BPS and BPF BPS exposure and cognitive outcomes in children at age 7 years. BPF Cognitive function Method: Women were enrolled in the Swedish Environmental Longitudinal Mother and Child, Asthma and Al­ Prenatal exposure lergy (SELMA) study, at gestational median week 10.0, and their children were examined for cognitive function at 7 years of age (N = 803). Maternal urinary BPA, BPS, and BPF concentrations were measured at enrollment and childreńs cognitive function at the age of 7 years was measured using the Wechsler Intelligence Scale for Children IV (WISC-IV). Results: All three bisphenols were detected in over 90% of the women, where BPA had the highest geometric mean concentrations (1.55 ng/mL), followed by BPF (0.16 ng/mL) and BPS (0.07 ng/mL).
    [Show full text]
  • T Williamson. the Desalting of Urines Prior to Amino Acid Chromatography
    " ' J R Army Med Corps: first published as 10.1136/jramc-112-03-12 on 1 January 1966. Downloaded from , " THEDESAL TING OF UiRINES P,RIOR TO AMINO ACID CHROMATOGRAPHY Sergeant T. WILLIAMSON, A.I,M.L.T;, RAM.C. Royal ArmyMedical Colleg~, Millbank Introduction THE need for a simple and inexpensive method for identifying urinar.yamino acids has been fulfilled to date by the use of paper chromatography; Before the urine can be chroniatographed for amino acids, inorganic ions a.nd, large ,neutral molecules such as , proteins must be renlOved. Ifleft in solution they will seriously impair the ~potsepa.~~i.ti,On. Several methods of effecting deionisation have been described and fll.ll into three main -categories: Organic solvent extraction ' , , guest. Protected by copyright. Verghese and Ram~krishnan (1957) described a method in which -urine isev'apor~ted: . to dryness and the amino aci.ds extracted from the residue with a mixture of phenoL ',.' '. and h~tanol. This become~ a lengthy procedure since dessication over~night is involve~( . Electrolytic diionisationand dialysis , . These two methods,described respectively by Consden etal (1947) 'and Wood (1956) . are very efficient, but fequife equipment not readily available. They are expensive,., taking .into account the factthat since 'the Army is a relatively healthy comnmnity, identification of urinary amino acids is a comparatively uncommon request. , Ion exchange resins ~mith (1958) indicated how a cation exchange resin could be used to adsorbinorganic-' iOrisandamino acids from urine ,followed by selective -elution, cbncentnltionand http://militaryhealth.bmj.com/ -chromatography of the amino acids. ' . " _. Thus a method fordeionising urines based onthis thirdcategqry has been found .
    [Show full text]
  • A HISTORY of ENDOCRINOLOGY: the Fantastical World of Hormones
    ISSUE 115 SPRING 2015 ISSN 0965-1128 (PRINT) ISSN 2045-6808 (ONLINE) THE MAGAZINE OF THE SOCIETY FOR ENDOCRINOLOGY A HISTORY OF ENDOCRINOLOGY: the fantastical world of THE JOURNEY TO MODERN hormones ENDOCRINOLOGY PAGES 6–24 Placenta as parasite PHIL LOWRY’S NOVEL PEPTIDE HYPOTHESIS BEHIND THE SCIENCE OF MORNING SICKNESS P26 Make the most of training THE NEW REGISTRAR’S SURVIVAL GUIDE, AND BENEFITS OF REGIONAL NETWORKS P32–33 YOUR CHANCE TO GET NEW! GET READY FOR INVOLVED EQUIPMENT GRANTS EDINBURGH Future Committee members Up to £10,000 support from Your SfE BES 2015 deadline apply within the Society dates P3 P29 P30 www.endocrinology.org/endocrinologist WELCOME Editor: Dr Miles Levy (Leicester) Associate Editor: Dr Tony Coll (Cambridge) A WORD FROM Editorial Board: Dr Rosemary Bland THE EDITOR… Dr Dominic Cavlan (London) Dr Paul Foster (Birmingham) Dr Paul Grant (London) Managing Editor: Dr Jennie Evans Sub-editor: Caroline Brewser Design: Corbicula Design Society for Endocrinology 22 Apex Court, Woodlands, Welcome to this ‘History of Endocrinology’ themed edition, which has come together wonderfully Bradley Stoke, Bristol BS32 4JT, UK well. We start with an introduction to the fantastical world of hormones, and then take a journey Tel: 01454 642200 through the modern history of pituitary surgery. Following this, we learn about key discoveries Email: [email protected] Web: www.endocrinology.org in parathyroid, adrenal, thyroid and oestrogen- and testosterone-related endocrinology. I am Company Limited by Guarantee very grateful for the time our big-hitting contributors have given up in order to write for us this Registered in England No.
    [Show full text]
  • British Society of Gastroenterology
    Gut: first published as 10.1136/gut.6.2.203 on 1 April 1965. Downloaded from Gut, 1965, 6, 203 British Society of Gastroenterology The annual meeting of the British Society of Gastroenterology was held at the Postgraduate Medical School of London on 13-14 November 1964 with Dr. Charles Newman as President and Dr. C. C. Booth as the local secretary. At the annual general business meeting the following THE pH IN THE DUODENAL BULB elections were made: President-Elect, W. M. Capper; Hon. Treasurer, G. D. Hadley; Hon. Secretary, H. A. J. RHODES, H. T. APSIMON, and J. C. PRESTWICH (Cardiff) Magnus; Council Member, R. B. Welbourn. Honorary SPONSORED BY A. H. JAMES The pH in the duodenal bulb membership was conferred on Professor Charles Code, was recorded continuously by glass electrodes in normal Sir Charles Dodds, Bart., Sir Howard Florey, Dr. Lionel subjects and patients with ulcer. After food the pH Handy, Professor Bengt lhre, and Dr. Ian Wood. The fluctuates rapidly between extremes of 2 and 7-5: at night following were elected to membership of the Society: there are long periods when the pH is neutral. Individual A. R. Anscombe, E. L. Blair, A. G. Cox, B. Creamer, rises in duodenal acidity can be associated with antral H. L. Duthie, H. Ellis, R. Franklin, A. G. Parks, P. C. contractions. Reynell, R. Smith, J. A. Williams, R. S. Williams. The Conditions of acidity in the ulcer-bearing area of the following were elected as Associate Members: P. E. duodenum are unlike those obtaining elsewhere in the Aylett, G.
    [Show full text]
  • How Toxic Chemicals in Personal Care Products Can Cause Harm | NDNR Page 1 of 6
    How Toxic Chemicals in Personal Care Products Can Cause Harm | NDNR Page 1 of 6 Categorized | Anti-Aging How Toxic Chemicals in Personal Care Products Can Cause Harm Posted on 16 October 2010. How Toxic Chemicals in Personal Care Products Can Cause Harm Anne Marie Fine, NMD and Sara Rodgers, NMD, MS Naturopathic physicians are experts in helping people decide what to put in the body; we are also well-positioned to provide expert advice on what to put on the body. Personal care products represent the largest class of avoidable exposures to toxic ingredients and yet have not received the attention accorded to carcinogenic and toxic pollutants in air, water, home, and workplace. Unlike these toxins, however, we can exercise control over what we put on our skin. Cosmetics and personal care products are not only the single most avoidable category of threats to our health, but they also have the widest range of alternative, safe products. The Food and Drug Administration (FDA) has no requirement for testing or approval before these products are marketed. There are also no mandates for label warnings identifying known allergens, carcinogens, or endocrine disruptors. This industry is self-regulated. While the European Union (EU) has adopted the Precautionary Principle in addressing potentially toxic chemicals in personal care products before release, the United States looks for irrefutable proof of harm before recalling toxic ingredients. Every day, at least 3 personal care products are applied to the skin of infants and children. Women use 6 or more cosmetics and an average of 13 personal care products daily, containing more than 100 different ingredients.
    [Show full text]
  • THE THYROID CYTOTOXIC AUTOANTIBODY the Presence of Circulating Autoantibodies in Patients with Hashimoto's Disease Suggests That
    Journal of Clinical Investigation Vol. 41, No. 5, 1962 THE THYROID CYTOTOXIC AUTOANTIBODY By I. J. FORBES,* I. M. ROITT, DEBORAH DONIACH AND I. L. SOLOMON t (From the Middlesex Hospital Medical School, London, England) (Submitted for publication November 27, 1961; accepted January 18, 1962) The presence of circulating autoantibodies in micromethod of Donnelley (6), and was known to sup- patients with Hashimoto's disease suggests that port good cell growth. Fresh normal serum was always used in tests with serum fractions or absorbed sera. autoimmunity is implicated in the disease process, Guinea pig serum could be used as a source of comple- but the ultimate proof of an autoimmune patho- ment but was occasionally cytotoxic. The cultures were genesis of thyroiditis and other human diseases incubated for 18 to 24 hours at 370C. must be obtained by demonstrating the autoag- The sensitivity of each gland was established by in- gressive action of antibodies or immunologically cluding as controls known weakly cytotoxic sera and competent cells on the living tissue in its normal potent Hashimoto sera, sometimes set up in dilutions. With sensitive glands, all the cells were killed by a environment. strong standard serum; the weaker sera usually allowed The demonstration by Pulvertaft, Doniach, Roitt a few clumps of cells to be established. Where cells and Hudson (1, 2) of a serum factor capable of survived in final dilutions of less than 1: 120 of the destroying human thyroid cells in tissue culture standard strong serum, the gland was too insensitive to is an advance in this direction. This finding has permit evaluation of unknown sera.
    [Show full text]