Bellwether Magazine

Volume 1 Number 7 Spring 1983 Article 1

Spring 1983

Bellwether 7, Spring 1983

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Recommended Citation (1983) "Bellwether 7, Spring 1983," Bellwether Magazine: Vol. 1 : No. 7 , Article 1. Available at: https://repository.upenn.edu/bellwether/vol1/iss7/1

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Transgenic Mice

• \Tou�t' &n '·•it wah Two mice were the stars of a press briefing in December fl•Oiltit h11rmunf l{enr•, 1982. One looked like any other laboratory mouse and the n ms••' nn rc�/11 1tt1huur • other was almost twice as big. Though they were sibli.ngs, • the big one carried genetic material from another species. 1t had genes for rat growth hormone. The birth of this mouse and six others marked the first time that sci.entists had succeeded in tnaking DNA from. one mammalian species function and be expressed in another mam.rnal in such a dramatic manner.

These mice were the cul'mination of sev­ eral years of rcsean:h by Ralph L. Brinster, V, i\l.D., Ph.O., Richard King 1\-fellon Professor of H.eproductivc Phy!iiology, S<:hool of Veteri­ nary Medicine, University of Pennsylvania, a principal investigator i11 these studies which were supported by grants from the National Science Foundation and the National Institutes of Health. The co-investigators were Dr. Richard P. Palmiter, Howard Hughes Medical

Institute, University of Washington, Seaule; Michael G. Rosenfeld, University of Californja, San Diego; Neal C. Birnbcrg and Ronald M. Evans, Salk Institule for Biolugieal Studies, La Jolla, California; Roherl E. Hammer and M}Tna E. Trumbauer, Laboratory of Physiol· ogy, School of Veterinary Medicine, University of Pennsylvania . • • • • • • • Dr. Brinster anci his colleagues have been conducting basic research to study gene regula­ tion and the genetic basis of development. In their experiments they introduced foreign

(continuedon page 2) Bellwether No.7 Spring �983 Transgenic Mice

(CI>ntinuedfrom cm-er) Bellwether is published We'd like to hear your genes into mammalian embryos at the earliest of these was removed from the zinc supple­ quarterly by the School praise. criticisms, or stage of gestation. The technique utilized wa." ment after two weeks and continued to grow of Veterinary Medicine comments. Please gene-splicing where DNA from one species wa." faster than normal. at the University of address your corres­ attached to the mouse metallithionein �T) Studies on the mice found that growth hor­ Pennsylvania, in coop­ pondence to: gene and then micro-injected into fertilized mone wa!l p1·oduced in the liver and other tis­ eration with the Uni­ Or. John Martin. Editor. mou!'ie eggs which were implanted into foster sues. Normally this hormone is produced in versity or Pennsylvania University of mother mice. the pituitary gland. Some of the mice had up Publications Office. Pennsylvania, The MT gene enables the body to bind to 800 times more growth hormone than nor­ School of Veterinary heavy metalR and have re11istance to these sub· mally expected in mouRe blood. It appears that Editors: Medicine, 3800Spruce stance�. It is present in most tis:;ues and most the overproduction is due to a lack of feed· Or. John E. Martin Street, prominently found in the lin:r. The gene is ac­ back, a mt:t:hanil'lm which regulates the pro­ Louise Stone Philadelphia, PA 19104. Li' ated �hen the organi!.Jn inge�ts heavy duction of the hormone when it is produced Writers: or louise Stone. metals, then mes..�nger RNA is produced by the pituitary gland. It was found that mice Marcia Maziarz Editor. University of which enables the ceJis to biotl heavy metals. with the �rreate:-;t amount of growth hormone Carol watson Pennsylvania In earlier e�:periment� Ur. Brinster, et al. had the largest quantity of the altered gene in Helma Weeks Publications Office, had fused the mouse MT gene with a virus their tissues. The experiment wall carried fur­ Or. Josephine Deubler 410Logan Hall, gene to measure specific vital en4!ymatic acth·­ ther. Mice possessing the altered gene were (Animal Crackers) Philadelphia. PA 19104 ity in the veU. The altered genes were micro­ mated to normal mice and of the nineteen off­ Designer: injected into fertilized mouse eggs which were spring, ten <'arried the gene. The offspring Two Twelve Associates None of these articles implanted into female mice. Some of the off­ with the new gene also grew larger than Photographers: are to be reproduced in S"pring showed the enzyme activity, generated normal. Diane Feltoon any form without the by the virus gene. when they were given heavy These mice demon�>trate for the first time Lynne Kressley permission of the metals. This experiment helped the researchers that gene�; can be transplanted from one mam· New Bolton Liaison: editors of Bellwether. to identify the !'!equence responsible for heavy malian sperie� to another and can be expressed Catherine Larmore ®1983 metal inducibility on the mouse MT gene. It phenotypically in Ruch a manner as to affect Circulation: by the Trustees of was this sequence that was attached to the rat basic metabolic function. ThiEl has great impli­ June Johns the University of growth hormone gene. cationH for reHearch. These mice can serve a!'. a Pennsylvania. In the lateRt experiment Dr. Brinster and model to study gigantism, a human genetic dis­ his <·olleagues modified the rat �rowth hor­ ealle. 1t wtHl found that the amount of growth mone gene hy remO\ ing it!> regulatory se­ hormOUt! produced by the mire far exceeded quences and replacing these with the regulat· the amount which can be produced by conven· ing part of the mouse MT gene. The section of tional methods. Tbu5, thP technique of fw;ing� the MT gene used was the 11equence which the MT gene to other genes controlling pro­ TltP u c of grou.•lh lwrmonc nwy also contains the MT promoter that helps control tein production in mammals may lead to expression of the gene in the cells of the organ­ ..genetic farming" where surh altered genes are hm 1 o,rrricultural UJlJ'Iication : perhaps ism. The altered gene was cloned. and the new utilized to produce protein suhstances such as mit• dm rt m11.\ hr> po.. ible to alter tht! gene was placed into fertilized mouse eggs by blood clotting factors used for hemopl1ilia. rnntl1 patlr•rn of ani nwl. produc<:d micro-injection. The re�earchcrs modified 170 The use of growth hormone may also have .fnrfmul u tlw\ Nm reuc!J tlte market egge; and the."e were implanted into foster agricultural application; perhapH one day it mother mi<'e. may be possible to alter the l{Towth pattern of 111 o lanrler rimP. Tlte {11 ifm Some:: ga'e hirth and twenty-one offspring animal11 produced for food so they can reach If dwu7u '""' oho hP utili::.ed in re11uhed. Tests showed that M!\·en of these had the market in a shorter time. The fusion tech­ d 1 PllltJm n r nf t m " u i tit f(reater inherited the altered gene. After weaning, nique may also be utilized in development of a1 nlulau � uf rruUc tJroductum these mice were fed a regu.Jar diet and small cows with greater capabilities of milk quantities of �inc, a heavy metal, were added produc1ion. to t heir water to activate the altered gene. Six The re�ear<:h by Dr. Brinster and his col­ of the mice showed tUI accelerated growth rate leagues opens important new avenues of study prior to the addition of zinc to their diet. One and will provide in�ight into gene regulation and the basis of development.

2 on the Rise

The number of reported rabie..� cases He also added that pet O\\"Tlers shnu1d Le in Pennsyh,ania, Maryland and advised to have their dogt� and cal." vaccinated against rabies. "'They provide a buffer between Jlirgin.ia has risen dramatically wildlife and the human popnlat ion," he said, during the last two years. In 1981, "They arc more likely to come into contact Virginia reported 102 cases o.f raccoon with rabid wildlife a�d if thev ure not vacci­ rabies ns comparecl to seven case.� in nated, they can transmit the �irus to people." He added that in l98l, for the fin;;L time, the 1980. By No·vember there were number of reported rtlbies cases io cats out­ seventy confirmed cases of rabies in numbered those in dogs. Rabies vaccines for Penn .sylvania in 1982. These included cats and dog!' are read ily available and some not only wildlife, but also Jour dogs offer prutec:tion for three year:-.... Out one must realize that prutectinn decline� throughout this and one cow period," Dr. Gli(·kman �aid. "Dog� and cats "The ri�k to human been has increased that stay inrloors; and are not exposed to wild­ the 11 ill r of hy p nve rabie� into domestic ani· life are adequately protC<'teri with vaccinations said Dr. T. Glickman, Chief, mals." Lawrence every three year� if a triannual va<'cine i� used. Sc·huol of Section of Epidemiology. Veterinary Animal� that run free and hunting dogs used Medicine, University of Pennsylvania. "'ln in the rielcJ, however, l!houlcl IJe \uccinated November 1982 a dairv cow from Lam·asler every year to provide maximum protection wus County admitted to the Large Animal Hos· against the diKease re�arrJless of the vaccine t pi al al New Bohon Center. The animal had to u!-led."' lie alNo explained that puppies vacci­ eu h after four be t �tnized days and it was found nate d prior to four months of age need a boost­ to have rabies. Veterinarians, veterinary and er vaccination one year later. '"Also, there really laboratory technicians, student!-� and nurses, should be a requirement that all dogs and cats had to undergo rabies post-exposure prophy­ be licemed and that pr·ior to recei,ing the laxis. This included thirty-two people in all at Hcense 1\ proof of ruhie� vaccination is manda­ New Bolton Center and six additional people tory." he stated. who had come into contact with the cow on There is no vaccine approved for use in t.he £arm and during transport to New Bolton wildlife and Dr. Glickman recommends that Center. The entire herd from which the cow people not purchase or t ake in wild animals al' originated �·as placed under a ninety-day pels. "'This can be quile cJuntterous because in 4uarantinc." :-ame animal� the in<'uhntion period for rabies This incidl•nt illw.trale:. the need fur vet­ is long, particularly in 'lkunks. It is heiil to erinarian� to �u.'�pect the possibility of rabies lea,•e wildlife alone. If one must handle wild­ in animals showing neurologic signs or abnor­ life, it should he rl�tne wi 1 h great care."' mal behavior. Or. Glit'kman recommends that Rabie� iH inv ariably a fatal disease and if a veterinarian!'�, veterinary perso nnel, and wild­ person has heen bitten or has comt: in contact life per·sonnel re<>eive a three-dose pre­ with an animal 1\U:ipectcd of hu" ing rabies. it is CApO�-ture rabie� prophylaxis regimen. "A new imperative that merlical help be �ought at killed "·accine is a"·ailable,'" he cxplah1cd. ·'Un­ once. ""The viru;; has a varying inl'ubation time; like the earlier vaccine which was developed it may take as little as three weeks to manifest from duck cmbr)'OS and which •·ould have liP al n addf d r!Jar I' r ou.ner �thouk ihelf, or as long as six to oint> months," he se"·ere l'ide effects. the new vaccine is produced b odt I !it ci to hm tlu tr rlo�s ond cal sairl.... Ea(•h year about 30,000 peri'OilR in the on human diploid cells, and was developed by rvr cUJflted agmn t rvllu ·· TI1ey United StaleR receive post-eAposure treatment the Merieux lrlslitute of Miami, Florida, and prot ide u bujjf•r I PI u t PPl H ildlife for possible rahieH exposure. This i� quite side effects are uncommon." The vaccine is expcnsi"c; il muy 1:ot�l between $500 to $700 to usua�y given aA l.Oml intn•muscularly, though mul tlw lwmcm [JDfJUitttirm.... lw .mid. treat one individual.'' studte� have �howl'• that it is just as effective "1'1r<'' trrt1 mon., Iii�·· h to come in fo One European country is experimenting when given in �maller doses (O.lml) intrader­ contwt u '''' rniJicl u drlltft and if with an oral vaccine for foxes which are their mally for prophylaxis. Dr. Glickman explained tlw' ar• not •vucmtllf d. llu?) ccm major reservoir for rabieB. (\.;o large-scale pro­ that the latter course is followed here at the

_ gram i1- being tried for wildlife here in the school where 'accination is o ffered to all stu· lrlJn mil tlu 1 iru11 rn I" opl United States. dents. '1'he vaccine, onre reconstituted, bas to The c:urrenl epidemic· uf raccoon rabie:-; be user! within three hours." he said. "'It is not which began in the 1970,; in Florida, will prob­ packaged fur intradermal injection� therefore., ably continue its march up the Eastern Sea­ when using this technique, one needs a gr(}up board. The only way of pre\·enting the disease of people to take advantage of the sa,•ings. A from reaching the human population is to l.Oml intramus<'ular dose costs about $45 where­ haYe all c•uts and dogs vuc:cinaled r egularly and as O.lml dose rosts about S6 if you get seven o r to avoid <'onlart with wildlife. Veterinarians ei�ht people together. This is wh)' we use this and other persons c·oming into <'ontaet with terhnique� it makes the vaccine affordah1e to animals !-�huuld consider pre-expo!!!ure "accina­ our sturlents." l>r. Glkkman did point out that tion�. Exposure lo a ruhifJ animal can affect the intradermal terhnique has not yet been ap· quite a n umher of people as shown by the pro\•ed by the FDA. However, the Immuniza­ dairy row at New Bolton Center and can be tion Practices Commitlee has a ccepted the 10 devastating psychologi<'ally. In the case of r egimen for pre-exposure vaccinations. All stu­ •·abies, prevention throug h varcination is a Jot dents who wam to work with the Wildlife Ser· wistlr and cheaper thun post-exposure vice at the sehoul m1JRl be vaccinated auainstb treatment. rab. ICS.

Spring 1983 3 alf rrhe e at e 0 nt r

Each year the agriculture industry suffers Researchers found that calves are horn has very few reserves. Its body protein is rapid· heavy lo�ses from calf diarrhea, a common dis­ with little maternal antibody protection. In ly depleted when it is fed only electrolyte solu­ ease of young calves. "It is a major loss to the order to obtain protection, calves must nurse tion for more than thirty-six to forty-eight cattle industry during the first year of life of within a few hours of birth to receive colos­ hours. If the regimen of feeding only electro· caule," explained Robert H. Whitlock, D.V.M., trum from the dam. It was found that calves lytes or diluted milk is continued, the calf Ph.D., Chief of Medical Service!'l at the Large can only absorb antibodies during this brief loses sufficient muscle mass to become recum· Animal Hospital of the School of Veterinary time span (first twenty-four hours of life), and bent, i.e. a bright and alert downer calf. Such Medicine, Universit)" of Pennsylvania, at New that absorption is at its optimum during the calves rarely survive even if given milk after Bolton Center. "Approximately forty-eight to first two hours of life. Thereafter the percen­ they are down. It is very important to con· fifty million calves are horn each year, accord­ tage of antibody absorption steadily declines. tinue to feed milk, even more than normal, ing to USDA �tatistics. The avet·age mortality Between 15 and 40 percent of the calves born particularly in the winter months when the per year is 3.5 million calves and the average fail to absorb sufficient antibodies. Some ani· young animal needs additional energy to keep annual loss exceeds $100 million." mals are unable to absorb the antibodies; warm."

•

•

Dr. Whitlock and his colleagues at New Bolton Center are conducting research about the causes of calf diarrhea. "It can be cau,sed by a number of different agen.u, though the most common one is E. coli, a bacteria which is abundant in the environment." The E. coli strain causing the disease in calves produces K 99, an antigen that allows the bacteria to adhere to the intestinal lining.

others are rejected by their dams. This oft.en 01·. Whitlock noted that a calf with diar· occurs with first calf heifers. In other cases the rhea can lose between three and five pounds dam may have mastitis, or its udder is so full of body weight per day and that this can be that the dairyman has to milk the cow, draw­ life threatening in a very short time. The a\'er· ing out the colostrum, and in some cases the age birth weight of a newborn <'alf is between calf is too weak to suckle properly. Efficiency ninety and 120 pounds. Dr. Whitlock empha­ of c:olo!!tnJm abRorption was found to be sea­ si:red the importance of continuing to feed sonal. During the winter months it is not as calves milk after they have been taken from well absorhed as during other times of the the dam. "We found that whole milk rather vear. It was also found that maternal behavior than milk replacer is better and more econom· �f tho dam, such as lkking and nudging her ical," he said. ••Milk may contain antibodies coli Dr. Whitlock and his c:olleagnes at New calf, increases absorption of colostrum. against E. and these prevent adherence of Bohon Center are c:ondueting research about Calves without sufficient antibody protec­ the bacteria to the intestine. They may provide the causes of calf dianhea . ..It can he caused tion are prime candidates for calf diarrhea. Dr. a protective antibody coating K 99 cannot by a number of different agents, though the ·whitlock's research evaluated the treatment of penetrate. Milk also provides antibodies most common one is E. coli, a bacteria which calves with the disease. "We produced the diar­ against other disease causing agents." Calf rais­ is abundant in the environment." The E. coli rhea in groups of calves," he said. "Some were ing practices have undergone Rignificant strain ('ausing the disease in calves produces fed an electrolyte solution only� others were changes during the last few years. "C...alves are K 99, an antigen that allows the bacteria to given a mixture of milk and ele<:trolyte solu­ now Left with the dam only for the first adhere to the intestinal Jining. Once adhered, tion." It was found that the mixture of ntilk twenty-four to forty-eight hours and then are the organism produces an enteroto�in that and electrolyte solution was more beneficial to placed in individual hutches rather than heing causes F.lome intestinal cells to alter their nor· the calves than electrolytes alone. "'We recom­ railled in an inside c�alf pen. Thi!! is the most mal absorptive function to set:rete fluid and mend feeding about 50 to 75 percent of the important advance made in re<�ent years. The electrolytes. Such lining l�ells normally absorb normal milk ration and complementing it with hutch isolation effectively pre"·ents the spread fluids and secrete only small amounts. The ex· an electrolyte solution. More research is need­ of calf diarrhea to other neonatal calve� and cessi\'e secretion dehydrates the c:alf as fluids ed to determine the best proportions of milk cuts down on the ec:onomic· los!!es to the and electrolytes arc flushed from the body as and electrolytes to give to calves with diar­ farmer."' diarrhea. As the severity of the diarrhea contin· rhea."' Dr. Whitlock explained that milk con­ E. coli is not the onl}' diarrhea-c:ausing ues the animal becomes more ill, its blood tains electrolytes in addition to protein and agent in young calves. A host of other bacteria thickens and its heartheat becomes irregular. other nutrients. "'The milk helps fullfill the and viruses are ready to invade an animal un· H prompt veterinary attention i!'l not given, caloric needs of the calf,"' he !!aid. "A newborn protected by maternal antibodies. Among the <:alf may die. calf iR in a very delicate nutritional balance; it them are the rotavirus, c:oronavirus, clostrid- needs 1:alories and protein to survive. It has very poor energy storage when it is born and

Bellwether 4 Medical Records., A Supportive Service

ium, cryptosporidia. campylobacter. salmonella A :;tudent working on a research project about record keeping was developed and written by and others. In order to determine which organ­ malnutrition needs to know whether such George C. Fambaeh, V.M.D., Ph.D., assistant ism is implicated in the disease. the veterinar­ cases were seen at VHUP during the last year. professor of neurology. It was designed to meet ian needs to do laboratory examinations and This may appear to be a tat'k involving a lot of no1 only the record keeping needs of the hos­ sometimes more sophisticated tests are neces­ record sea1·ching, and in previous years this pital hut also the research and teaching sary to determine the course of treatment for would have been true. Then all diagnoses wet·e requirements. The program, whit:h is not a par­ the individual cal£. While E. coli alters the recorded on Termatrex cards, a eoding system ticularly large one, allows fot· storage of in· function of the intestinal cellN, a virus like the punched on cards. To obtain information the formation on 800 diseases and disorders, each coronavirus destroys a portion of the lining. In researcher had to examine many cards to find coded with a number. both cases the calf improves only after the al­ the relevant patient files. It is not in its final form. "'We get input tered or damaged cells have been replaced by Now the researcher contacts Rosanne from the staif."Mrs. Hinrichs said. "We continu· healthy ones. During the course of the disease Hinrichs. director of medical recot·ds at VHUP. ally ask what is needed in terms of informa­ all that can he done is to offer to�upportive who, together with her staff of three, institot· tion, and we upgrade the system as the needs lrealment. ed a computerized medical records system at are die�covered." the hospital. All it takes is to poBe the ques· The system permits many use!!, such as de­ tion to the computer and in minutes a print· termining the number of cases of fradure, out listing all the f!ases, the specie, and the infection, viral dilleases, and the like. It and so on, is recorded on the admis!!ion form Dr. Whitlock explained LhaL many dairy­ from the Department of Ontpatient Medicine and a plastic imprint card with the patient men treat their cattle whh antibiotics at the at HOP, medical record!! was a complicated sys· number is prepared. This initial information i!l first sign of trouble. "Antibiotics are of no tern where records and cro�:�s references were fed into the computer when the record comes value ln viral diarrhea and ot' questionable kept in different places. "We found that the to medical records af1er the visit. The record. value in bacterial diarrhea," he said. "They are old sv!'ltem, where a new c·ase number was as­ whieh also contains information about the iU­ to the patient each time it wa,;. admit· �ivt>n primarily to prevent sept kem.ia... He ex­ signed nes..,, general condition of the �nimal, treat­ plained that antibiotics kill certain har:teria in ted, <'ould not handle the grcnving case load,"' ment. lal1oratory tests, and other findings., is the calf but do not affect those fluid secreting she explained. not filed until it is completed by the clinician cells which are the reason the calf ha� diar­ The new system is patterned after the in charge who records the diagno�;i8 and the rhea. Antibiotics may prevent the adherence of med·ical r:ecords system ut-�ed in human hospi· discharge status. Then the recot·d is coded, the additional bacteria as new cell growth takes tal-;. Each animal is assigned a �ix-digit number diagnosis and discharge information arc added plac!e and contaminated <;ells are eliminated which is used for all subsequent visits and the to the computer records, and the file is placed from the body. "But we Ree resistance to anti­ records a1·e kept together under this number. in storage. L"nder this syl'!lem files can be locat­ biotics due to indiscriminate and improper use "This provides continuity of care, it considers ed quickly. Currently there are 60,000 files in of these drugs and we find many organisms the animal all an entitv and makes lt easier for the medical records office on the second floor which arc resistant to ••ommonly used antibiot­ faculty and researc·he;s to obtain information,"' and each year about 18,000 are added. Mrs. ics." To reverse such a trend in a herd can be MrR. Hinrich.� said. llinriehs explained that the computer records very costly. "'We restrict the use of antibiotics The computer program which replaced are up-to-date, enabling researchen at the and the retSi:.-t.ant strains, after a whlle, \\-ill re· the key punching and much of the manual s<:hool to obtain cw·rent information on the vert hack to �:�n ordinan strain," he said. ''But nature of easel! seen. in the meantime the da'iryman may lose some Medi<:al records is re�J)Onsible for having animalH. However, this can be minimized by available the records of animals that come in improving the management, i.e., ensuring colos· for •·epcat visits. Such 1·ecords are pulled the trum, keeping the calves dry and in hutches, day prior to the visit when the medical records etc." office receives the appointment s

Spring 1983 5 Toxocara ••••• 0 •••••• ••• ••• -a public

controUing the inflammation caused by the Jar· vae. The patient has to be removed from his environment to prevent the child from rein­ fection by eating contaminated soil. VLM is rarely fatal, though one death was reported in Philadelphia recently where an autopsy of a six·year-old child revealed ma11sive larvae infes­ tation in the brain. Occular larva migrans (OLM) is a Toxoeara infeBtation confined to the eye. OLM patients rar·ely exhibit the signs of VLM, and there have been only a few cases reported where a patient had both OLM and VLM. In the eye the lan:ac can cause severe problems, even blindnes�. In the past, O.LM patients were often diagnosed as having retinoblastoma and the �ye was removed bec�ause OLM resembles that tumor. :"Jow with the ELISA test physicians can make a definite diagnosis of OLM and attempt to save the eye. Patients are lre�tted with anti· inflammatory drugs to reduce the ocular 1n-

• cara canis

A new puppy is brought home and a few days Scientists first speculated in 1921 that flammation hut the lan-ae cannot he removed...... ­ later it is taken to the veterinarian for vaccina· Toxocara from non-human hosts might be im­ They may become dormant only to hegin the tioos and an examination. The visit includes a plicated in human disease. This nution was con· disease prhould worry, insist�> Lawrence T. ha"e been reported in children between the eventu�tlly wind up in the eye," he said. ..More

Glickman, V.M.D.• Dr.P.H .. As;;ot·iate Professor ages of one to six years; the OLM patient� tend •·esearrh i� needed to determine at which level!\ of Epidemiology and Puhlic Health at the to be c!hildren in the age group 1-'ix to thirteen Toxocara larvae activate the 1mmune system." Sc!hool of Veterinar·y Medicine, University of yea1·:-;. OLM patient;; usually do not have a history of Pennsylvania. "'Roundworm larvae, when "ingest· OL.'\l and VLM have differ�nt clinical dirt pica and they tend to come from a higher ed by humans, can eause serious disease and, manifestations. Both arc cau!led hy the inges­ !-locio-economic group than VLM patients. in rare instances, death. Toxocara canis, and, to tion of Toxocara larvae. Most of the chlldr�n Many pa1·ents of young OLM patients are not some extent, Toxocara cari (cal roundworm) with VLM have a history of dirt pica (dirt eat· aware that their chiltl has the disease and are a public health problem in this country ing), and they pick up the larvae when eating often these children are identified during rou­ anrl all over the world. Soil samples taken eontaminated soil. These ingested eggs hatch tine check-ups at schools or by the pediatrician. frum park;; and playgrounds in different area!-� in the stomach of the child and then the lar­ Do�s and cats are all around us, they live of the United States and Canada show that one ''ae migrate to the liver where the body at­ at> pets in homes or as strays in streets and third of the sampled areas were rontaminated tempts to fight the invaders through an immu­ parks. Thus, even with tough clog laws, it is with Toxocara canis eggs." nolof!;ir· t·eactjon. At th�is stage the child shows very difficult to eliminate Toxocara eggs and Dr. Glickman has devoted considerable signs of illness. If the larvae infestation is larvae from playgrounds and backyards. There time' to the study of diseases caused hy mund­ grentcr than the immune system can handle, i:), however, something whlch can be done, aL�­ worm larvae, and with two other researchers larvae move from the liver to the lung and cording to Dr. Glickman. "'The key to redudng he developed an enzyme-linked immunosor­ from there to other organs in the body. The the prevalence of Toxocara larvae in the hent assay (ELISA) Lo detect the present:e of migration is accompanied by further Immune ground is by preventing roundworms to ma· larva infection in people. The test has been reHctions and tl1e patient may show signs of ttu·c in puppies."' available �ince 1975 and it haR been used here asthma, pulmonary disease or sei1.ure� de­ More than 90 percent of all puppies are at the Veterinary School, and at the Centers pendin� on where the larvae are located. born with the parasite and the$e worms are for Disea!!e Control, Atlanta, to make a defi­ VLM can take a long time 10 manifest it­ 1 he primary source of eggs and larvae. Round­ nite diagnosis of visceral larva migrans (VLM) self. Diagnosis is often difficult because the worm!! have evolved a complex life cycle which or ocular larva migrans (OLM). two diseases in signH of the disease vary depending on the or· permits intermediate ho!i'ls and which makes humans caused hy Toxocara larvae. gans involved. The ELISA te�t is of great help eradication of the worm almost impossible. to confirm the presence of Toxocara larvae. Adult dogs and bitches carry roundworm There are no drugs currently available which larvae in their tissues, but they do not nor- can be given to kHI the larvHe in human tissue. Present therapy is supportive and aimed at

Bellwether 6 Penn Annual Conference

• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • health danger mally cause the reaction seen in humans. weeks old. There should be subsequent worm· We';e getting older, bigger, and better! As the When a bitch is pregnant, after the forty­ ings at four, six, and eight weeks. This practice School nears 100 years, a very special Penn second day of gestation, these larvae migrate to eliminates most of the adult roundworms in Annual Conference is planned for January 2S the fetus whe1·e they settle in the liver. Once a puppies and greatly reduces the shedding of and 26, 1984, at the Franklin Plaza Hotel in puppy is born, the lanae migrate to the lung eggs. Center City Philadelphia-and if the 1983 and from there into the tra<:hea whet·e they Dr. Schantz and his colleagues at the Cen­ Penn Annual Conference is an indication, we are swallowed. They develop into adults in the ters for Disease Control conducted a random can expect a turn-out large enough to warm small intestine. survey of 100 veterinarians to find out what the whole month of January. By the time a puppy is three weeks old it wor�ing routines were recommended to The 1983 Conferenl:e held at the Philadel· has adult roundworms which are capable of lay­ clients. They found that only 7 percent of the phia Hilton attracted 800 participants includ­ ing eggs. These worms can live up to six months veterinarians surveyed recommended the ing: 450 practitioners, 100 speakers and faculty, and a female can produce up to 200,000 eggs a worming of puppies at less than three weeks of 100 students, and 60 scientific exhibits staffed day. Puppies may receive additional larvae age; 34 percent recommended worming by the by 120 representatives. from the bitch while nursing, through trans· fourth week, and the balance of the sample Small Animal topics covered a variety of mammary migration. This influx reaches its recommended worming between six and eight medi<�al and surgical problems such as: bleed· peak at. the second week of the puppy's life weeks. It was also discovered that 77 percent of ing and skin disorders, epilepsy, parasitology, and ends about thirty-two days after birth. the veterinarians would not treat fot· round­ anesthe!olia, radiology, hormone imbalances, and These larvae wilJ also mature into reproduc­ worm without a fecal sample; only 23 percent human/animal interactions. Dr. Bradford tive adult. roundworms. routinely wormed puppies without a sampJc. Smith, from the University of California Roundworm eggl'i are not infective until '"The veterinarians can have an important School of Veterinary Medieine, spoke on they have emhryonated. This process Lakes he­ role in eliminating this public heahh hazard equine salmoneUosis, liver diseases, and pneu­ tween two to five week.s. Embryonated eggs, by routinely recommending to their clients monia in foals. Other large animal topics in· when ingested by humans or animals, hatch that the puppies and the bit<:h are wormed at eluded bovine orthopaedic problems, bovine larvae. It was found that unembryonated eggs two, four, six, ancl eight weeks," Dr. Glic:kman medicine, calf diarrhea, equine botulism, radi· can survive for years if conditions are favor· said. "The veterinarian has to educate his ology, and ophthalmology. able. So far no agent� other than extreme heat, clients and explain the hazards of To xocara The Robert S. Brodey Memorial Lecture has been found to destroy the eggs. They can infection and the importan,:e of keeping the was presented by Dr. William Hardy. Head of .remain in the soil and embryonate later when whelping area and the yard cleaned up to pre· the Laboratory of Veterinary Oncology at the environmental conditions are favorable. vent eggs from settling into the soil." Memorial Sloan-Kettering Cancer Center in By the time a puppy -is 1ive weeks old it Dr. Glickman goes a step further. He advo­ New Yo rk. Dr. Hardy lectured hefore an audi· has begun to develop an immunity toward cates that each puppy which is placed in a new en<:e of over 300 on Retroviruses and Animal roundworm. 'Most of the ingested larvae no home he accompanied by a certificate stating Cancer Genes. longer develop into worms but instead migrate that it has been wormed and is free of the Dm·ing intermissions and lunch, senior vet­ to tissues Lo resume. migration if the host is parasite. He feels that this should be law and erinary students had time to meet future em­ female and becomes pregnant. Then the cycle should apply to aU puppies, whether they ployers. Sixty practitioners (37 Small Animal. begins anew. It has been shown that adult come from a private breeder, a pet shop, or an 21 Mixed Pradic�e. 2 Large Animal) requested dogs, other than lactating hitches, rarely have animal shelter. He also advocates strict enforce· interviews with students to fill positions in roundworm infestations. ment of leash laws and greater efforts to elimi· their practice. The students supervised the in· Common practice is to worm puppies at nate the stray dog population. Such preventive Lerview schedule from a private interview six and eight weeks of age. However, by then a measures, together with eacly worming of all room. The Sc:hool is proud to he able to help puppy has shed millions of eggs. Dr. Glickman puppies, would decrease the inddence of OLM its students and area practitioner·s find mutual· advocates worming puppies and nursing and VLM in children and reduee the stigma of ly beneficial employment opportunities via the bitc:hes for the first time when the litter is two dogs as a public health hazard. Penn Annual Conference. Another important function of the Penn Annual Confer·ence is to allow students, facul­ ty, practitioners, and staff to meet and mingle in an informal atmosphere. On Wednesday evening, January 26, the Dean hosted a recep· tion and buffet wher·e conversation ranged from sports, finanee!ol, and auto repairs to com­ plex medical and surgical problems. Twenty aulo-tutorial programs were avail· able in a private s<:reen1ng room for thoHe who wanted a break from the lecture format. Video To xo and slide programs on Orthopaedic and Soft Tissue Surgery, Exotic Animals, Rabies, Lame­ ness, Conformation, Gait, Biopsy Techniques and Chest Tube Placement were popular items with praditioners. The Penn Annual Conference offers ten· hour·s of continuing edm�ation credit, thus ful­ filling the requirement for relicensure in Pennsylvania.

Spring 1983 7 Sails, Masts, Fins and C A M E

Baltic trader and was in service for forty years between Greenland and Scandinavia," he ex­ plained. "In 1970 !!he was bought by a Cana· dian who had her refitted into a yacht. The work was done in Denmark and the craftsman· ship is superb." Dr. Hardy and his friends bought the Lind0 five years ago. Her deck is ninety-two feet long and twenty-two feet across and she sleeps ten guests and a crew of eight. "She is in the Caribbean where she is char· tered to individuals or corporations for cruises," he said . ... The Lind0 has a permanent captain and a crew of five. The crew arc most· ly young people, many are college students who take off for six months to work abroad. The captain loves the ship and keeps her in tiptop shape. It's expensive owning her. She was bought as an investment, but she is no money maker." Dr. Hardy spends alwut two weeks a year on the Lind0 and he was aboard when she came to Philadelphia last year to participate in Philadelphia's 300th birthday celebration. She was part of the flotilla of Tall Ships sailing up the Delaware. The faculty of the veterinary !!Chool had a fit·st-hand opportunity to inspect the ship during a party given by Dr. Hardy. ''lt is hard work sailing her, everything is done by hand. The sails have to be hoisted by hand and this can be dangerou�. During one

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hurricane off Bermuda several years ago the captain and one member of the crew were pinned on the yards when they tried to reduce illiam D. Hardy, Jr., (V '66) deliv­ veloped a rapid and sensitive indirect immuno· the square. They were caught up there for a ered the Brodey lecture at the 83rd fluorescent antibody test for feline leukemia long time. Fortunately they were not burt and Penn Annual Conference. "1 felt virus. In addition to his work at Sloan­ we did not lose the sails or the mast," Dr. "ery honored to be asked," Dr. Kettering he heads the National Ve terinary Hardy said. Hardy s11id. "Dr. Brodey was a good friend and Laboratory in Franklin Lakes, N.J., a private On a trip this summer the Lind0 was not it was he, who, together with Bob Marshak, en­ laboratory which test!\ for the feline leukemia quite so fortunate. "She had been chartered couraged me to go to Memorial Sloan-Kettering virus. "We get blood slides from all over the for the filming of All The Sad Yo ung Men and Cancer Center where I got in on the ground world," he explained. "\..ats can he carriers had to be brought to Chicago through the floor of cancer immunology." Today Dr. Hardy without 11howing signs of the infection and, be­ Great Lakes. It took five weeks to get her is the head of the Laboratory of Ve terinary cause the virus is spread through the saliva, it home from Chicago and we lost three sails." Oncology at that in!'!titntion. is important to identify carrierl>." This was not the firr�t film for which the Lind0 He produced the first antiserum to feline Dr. Hardy loves his work but to get away provided a set. She also starred in The Island leukemia vinu1 in 1968 and identified the inter· from the demanding schedule he skin-dives and was the "main character" in a NBC docu· species (gs-3) antigen that is found in most and sails. It is his love for sailing which caused mentary of the 1980 tramo�atlantic race from mammalian oncovirusel! in 1969. Dr. Hardy de- him to buy the Lind�, a three-masted top-sail Boston to Norway. "She came in second overall schooner. He co-owns the ship with two others, in that race," Dr. Hardy said proudly. He Dr. Tony PaJminteri, a veterinarian, and an ad­ vertising executive from New Yo rk. "She is a

Bellwether 8 New Referral Procedures­ Opening Channels of R A Communication

hopes that a sponsor can be found for next A new referral system at the Veterinary Hospi· within two weeks of the client's.visit. A moni­ year's transatlantic race. "Last year there was tal of the University of Pennsylvania (VHUP) toring system has been inHtituted to ensure no American ship in the race, even though it went into effect in December 1982. The new that the practitionerts recei"-e this final report. originated in Newport, Rhode Island." procedures, according to Dr. Kenneth C. Dr. Bovee encourages practitioners who find When sailing on the Und0 or other ships, Bovee� Chairman of the Department of Clini­ that this policy is not being followed to con· Dr. Hardy is not content resting on deck. He cal Studies, were designed by a joint commit­ tact the hospital administration, either Barry pursues his other hobbies, skin diving and un· tee of hospital clinicians and local veterinary Stupine, Hospital Director, or Dr. Bovee. derwater photography. ''I love skin diving and practitionet·s to facilitate communication he­ Practitioners, rather than owners, are ad· I dive to photograph." He usually carrie!l a de· tween hospital and practitioner. vised to contact the hospital if questions about vcloping kit and processes his slides right on Cases are regarded as referrals only if the a case arise. "We are always available for such board. ''That's easy and then you can see practitioner sends along with the client either consultation and we encourage this contact whether you have the correct light. If things a letter or a referral form stating particulars with the School� however, because we are a didn't turn out, you can go hack and take about the animal, its treatment, a provisional teaching institution, we are not able to func­ more pictures." diagnosis, or the reason for referral. Practition· tion like a regular medical office," said Dr. Last summer Hardy ll'aveled to Au!ltralia ers are asked to send along recordll of laborato· Bovee. "Our clinicians are not on hospital duLy to join a diving trip to a remote atoll in lhe ry tests and radiographs. "'This give us an idea full time. They have teaching, administrative, Coral Sea which lies beyond the Great Barrier of what the practitioner is thinking about and and retsearch duties and most are in the clinic Reef. "'There was a reporter from The l\lew it makes it easier for the clinician," tsaid Dr. only two or three days a week." Clinicians will Yo rk Time.'> aboard to do a story about the Bovee. ""ln addition, it saves time and money make every effort to return practitioners' calls voyage. One of my pictures was used when Lhe as test!l do not have to be repeated." as soon as possible. article wall published," he said. Once the referral case hall been seen, the Referrals provided by practitioners enable Hits love for diving and underwater photog· animal may be sent home on the same day students and staff to gain access to difficult raphy tak.e him Lo many parts of the world. with intermediate treatment measures. A refer­ and challenging cases. In addition, the sophisti­ "In 1977 J helped start the Society for Aquatic ral post card, mailed by the hospital within cated diagnolltic facilities at VHUP provide Veterinarv Medicine," he said. "'We have about twenty-four how·s, will inform the practitioner practitioners with assistance for patients with 300 members from the USA and Europe. We ubout which clinician saw the animal, the tenta· rare or complex diseases. Mote than half of travel all over to dive, to get together and to tive diagnosis, if the animal was hospitalized, the 19,000 cases seen at VHUP during the laHt discuss marine biology. We meet about three and what therapeutic mea!lures were pre· year were rcferrak Keeping open lines of com· to four times a year to dive all day and lecture scribed if the animal was sent home after the munication between hospital and practitioner all night. Usually there are about twenty vet­ <'.onsultation. is essential. In addiLion to the new system for erinarians on these trip�� mo.st are avid In cases where an animal is seen through referrals, VHUP encourages practhioners to photographers." the Emergency Service, practitioners arc asked vi!\it the hospital-to look around and observe to cal! the service to provide the pertinent in· procedures. "This helps practitioners to make formation and Lo alert the staff that the owner contact with the staff and to get to know is bringing the animal. If the animal is admit· them. It creates a better atmosphere and ted through the Emergency Service, the post makes for a better relationship hetween U!l card with a diagnosis follows after the animal and the oulside world," Dr. Bovee added. Such has been assigned to a medical �en'ice. contact is also encouraged through the continu· In order to provide a complete diagnosi>�, ing education program, the annual conference, it hlay be necessary to wait until the results of and meelings with area practitioners. all tests and studies are complete. This may Dr. Bovee hopes that the new system of take several days to more than one week. The handling referrals, the information booklet hospital clinicians will l!alJ or write the refer­ about the services at VIIOP, the referral form, ring veterinarian with a complete diagnosis and the feedback post card wiH provide addi­ tional channels of communication and enhance the cooperation between the teaching hospital •Ill and practitioners.

It is not surprising that Dr. Hardy has such great interest in marine life. "I have al· ways been interested in marine biology and had applied to graduate school Lo pursue it," he said.. . I was also accepted at Penn and I chose then to become a veterinarian. But my interest in marine biology remains." Dr. Hardy has a busy schedule. He lectures at the Cornell Graduate School in New York and he is ad· junct associate professor of oncology here at the Veterinary School. He also travels extensive­ ly to lecture to veterinary groups all over this (!Ontinent. "I like it. I enjoy meeting and speak· ing to practioners. Recently I gave an all-day lecture in Manitoba, Canada." Dlll·ing the ski season he tries to combine lecture tripts with a ski vacation fot· his family. "We try to get out West each winter," he said. He lives with his wife Susan and their chil­ dren, Billy and Smr.anne, in Northern New Jer­ sey. His children enjoy the sailing and his wife prefers the skiing. The family has four pets, three cats and a Labrador retriever puppy.

Spring 1983 9 The Loyal Red and Bl e

lu As the Annual Giving year enters its final months, The student lounge of the Rosenthal Building was Planning for class reunions and Alumni Day is alumni. parents, and friends of the School of Veteri­ filled with hungry, muscle-sore veterinary students underway. Veterinary classes celebrating class reun­ nary Medicine are once again responding to the chal­ and faculty, and their families on Saturday night, ions are being contacted by class presidents and lenge of meeting the goal for 1983-$200,000. January 8. As beer, donated by the Alumni Society reservations for parties have been made at inns in Over the years there has been a remarkable in­ and SCAVMA was Quaffed, hoagies and pretzels the Kennett Square area. Most classes are celebrat­ crease in the amount of annual giving. Ten years munched, the results of Sports Day 1983, were tallied ing in conjunction with Alumni Day activities sched­ ago, the Fund received $77.228. Meeting this year's by Jim Reed, third-year student coordinator. uled for May 21 at New Bolton Center. The Class of goal by June 30 will mean an increase of nearly 200 Sponsored annually by the Veterinary Alumni 1933, celebrating its fiftieth, and the Class of 1958, percent. This has been possible through the in­ Society, the day brought some 250faculty and stu­ celebrating its twenty-fifth reunion will be honored creased participation of alumni classes in the effort. dents into friendly competition. At Hutchinson Gym with a dinner at Allam House the evening of May 21. According to Or. Nancy 0. Brown, Alumni teams representing each class and the faculty Alumni Day will begin with a coffee reception Society President, the classes of the Seventies have battled away at badminton. basketball. squash, with Dean Marshak, a video presentation, and tours responded to appeals with increasing participation racketball, volleyball. and swimming. Levy Pavilion of NBC conducted by the faculty. Alumni will gather and amounts. Increasing the number of donors as hosted a series of tennis matches. The Alpha Psi at Alumni Hall for the annual meeting of the Veteri­ well as the total receipts has become very important House was filled with ping-pong tournaments. By nary Medical Alumni Society, chaired by Or. Nancy 0. to the School. "The percentage of participation afternoon, veterinary runners were huffing through a Brown. among alumni, rather than the size of the gift, is three-mile course along Boat House Row in Fair­ Following the meeting, during which awards will often an important factor when corporations and mount Park. Points achieved by winners in each be presented by the Society to outstanding veterinar­ foundations review grant proposals." explained event were tallied to find an overall team winner. ians, alumni will spend the afternoon en oying a tra­ j Elizabeth Caulk, Director Of Annual Giving for the Vet­ A large bronze Sports Day plaQue, to be en­ ditional barbecue and visiting. The party atmosphere erinary School. Last year, the Class of 1968 gave graved with the name of each year's winning team. will be heightened with music, flying of class flags $12,285. The Class of 1952 mustered 69 percent of its will soon hang in the VHUP student lounge. The and a display of the buggies and wagons kept at members as contributors. plaque donated by Adelphia Graphic Systems, will New Bolton Center. Chairman of the Annual Giving Campaign 1982- show ''The Class of 1984" as a two-time winner of Information regarding both reunion and Alumni 83, is Or. William B. Boucher, Emeritus Professor of the event. Second place went to the second-year Day will reach alumni by mid-April. Further informa­ Medicine. He has appealed to alumni and friends class, organized by Barb Flickinger. Third place was tion is available by contacting the Veterinary Alumni alike to continue and increase their support of the captured by the faculty team. organized by Or. Affairs Office. School through the Annual Giving habit because this Charles Newton, Associate Professor of Orthopedic money provides an essential source of unrestricted Surgery, and his assistant, Dr. Chris Hutson. Other

funding for support of the hospital and laboratory coordinators. were Rick Grgurich. fourth-year, and services as well as the high quality of teaching, re­ Karen Blumrick, first-year class. search, and clinical programs of the School. As food and beer disappeared, Sports Day par­ ticipants "limped" out to begin another semester of study and pressure. All agreed that this was a great way to get the winter semester off to an energetic start. Football team of the Ve terinary Department c. 1906

Crt'W of tlte Ve tf'rittary Dep(lrtment c. /906

Bellwether 10 Symposium. The Veterinary Hospital of the University tissue. mammary glands, lymphoid organs, including Heartworm Prevention. Heartworm Disease occurs in al­ of Pennsylvania presented its Thirteenth Annual the spleen. oral cavity, male genital system, respira­ most every part of the United States. It is transmit­ Symposium. Your Ve terinarian and Your Dogs to a tory system and bone. The incidence of cancer in the ted by mosquitoes and preventive medication may capacity crowd. dog is not known-it could be more than 1,100new be recommended by your veterinarian. This is not a Dr. Donald F. Patterson spoke on Disorders of cases per 100,000 dogs per year. do-it-yourself situa1ion. It is important that a blood Sexual Development. In mammals. including dogs, Inherited Skin Diseases were covered by Or. test be done to determine whether or not infection Vicki J. Scheidt. She described a hereditary blis1ering exists. Preventive medication should be used only if disorder (Epidermolysis Bullosa) reported in Collies tests are negative. The medication must be given and Shelties and Canine Color Mutant Alopecia. an daily. Your decision may be based on the mosquito abnormality pnmarily affecting the hair follicle in population in your area. whether or not the dog is color mutants (blue, fawn) of certain breeds. She outside at n1ght when mosquitoes are most active or even the cost of medication. Your veterinarian is the one to help with your decision.

Somali Cats. A reader wntes that the Somali is a long� haired Abyssinian and, except for lhe medium-long coat. is exactly like an Abyssinian. In the last issue 1 1 of Belfwether (#6), cat coats were described as Short� hair or Longhair. The Somali has a medium-length coat-the tail is a very full brush, and was incorrectly described as Shorthaired. In the same paragraph, the Rex was shown as Red. Ttlat was a typographical error. The Rex is a Shorthaired cat with curly hair. the sex chromosome of the male is XV and that of the female is XX. Males with the XXY Syndrome de­ velop as males but are sterile. females with the XO syndrome develop as females but are sterile. This is Cra-...... diagnosed by microscopic study of the chromosomes. There are five types of intersexes (often called hermaphrodites) recognized in dogs where it is not also discussed familial diseases: allergic inhalant der­ An excellent reference is A Standard Guide to possible to tell definitely by observation whether the matitis, hypothyroidism. seborrheic dermatitis and Cat Breeds edited by Richard H. Gebhardt, Grace animal is a male or female. There are also male generalized demodectic mange. Pond and Or. tvor Raleigh (McGraw-Hill). pseudohermaphrodites with XY chromosomes but in· complete masculination. Female pseudohermaphro­ Tapeworms are a common intestinal parasite of dogs Popular Breeds of Dogs. The American Kennel Club has dites have XX chromosomes and ovaries but their and cats and can be difficult to control. Usually they released registration figures for 1982. Based on num­ other genital organs are masculinized and the ani­ are no! harmful to the animal, but the segments are bers of each breed registered. Poodles were in first mals may be raised as males. In some cases, this unsightly and owners become concerned. place (88,650), followed by Cocker Spaniels (87,218), condition has been shown to result from administra­ There are several species of tapeworms and all Doberman Pinschers (73, 180), Labrador Retrievers tion of male hormones during pregnancy. require an intermediate host. Dipylidium caninum is (62,465), Golden Retrievers (51.045), Miniature Or. Patterson said that cryptorchidism is the the common dog tapeworm and its life cycle requires Schnauzers (36,502}, Beagles (35,538), Dachshunds most common defect of sexual development in dogs. the flea (or louse). The flea ingests eggs which have (32.835) and Shetland Sheepdogs (30.512). 01 the 125 occurring in 10-13 percent ot male dogs presented to been passed in the tapeworm segments, the parasite breeds of dogs and the 1.037,149 total registrations, veterinary clinics. Based on present evidence, a sub­ develops in the flea and the dog swallows the flea. the bottom of the list includes Sealyham Terriers, stantial reduction in the frequency of cryptorchidism The worm matures in the dog's intestinal tract and American Foxhounds, English Toy Spaniels, Curly­ could be brought about if unilateral cryptorchid its head becomes firmly imbedded in the lining of the Coated Retrievers. Belgian Malinois. Harriers, Otter males. as well as their parents. are excluded 1rom intestine. The head produces segments which even­ Hounds, Field Span1els, Sussex Spaniels and English breeding. tually are passed. These segments may be seen Foxhounds. Foxhounds are not a "rare" breed but Dr. Peter F. Jezyk's topic was New Developments "crawling" over fresh fecal material and around the owners use other registries. in the Understanding of Inherited Metabolic Disease. dog's tail. The segments soon dry up and look like These diseases are the result of altered structure and grains of rice. Age of Dogs and Humans. Any comparison is an function of proteins and enzymes. The results may Treatment will be ineffective unless the head of "educated guess" but it's otten said that one Y€ar in be inconsequential or lethal. Te sting procedures are the worm is destroyed. A new injectable drug (Prazi­ the life of a dog is the equivalent of seven years in available to detect these conditions which may be quantel) is giving good results. However, even if all man. A recently published chart states that it has a one of the causes of neonatal death. the tapeworms are removed, re-infection is probable more accurate measure: Dr. Mark E. Haskins described Lysosomal Stor­ unless the intermediate host is eliminated. Flea con­ Dog/Human age Disease in Dogs. These are genetic diseases trol must be considered part of the treatment for 1 yr./15 yrs. caused by enzyme malfunction. Six diseases have Dipylidium. 2 yrs./24 yrs. been described in dogs, some have a neurologic Ta enia is another species of tapeworm found in 3 yrs./28 yrs. course resulting in death before one year of age. In the dog. It is found more commonly in country dogs 6 yrs./40 yrs. some of the diseases, abnormal facial characteristics which acquire the worms by eating infected rabbits, 9 yrs./52 yrs. are seen. Children have diseases almost identical to mice or other rodents which are the intermediate 12 yrs./64 yrs. those in the dog. host. There is no hard and fast rule, as there are great Canine Epilepsy was discussed by Or. George C. There are a number of other tapeworms which variations in different breeds. The small breeds seem Farnbach. He emphasized that 'seizures' and 'epi­ may be found in the dog. A textbook on parasitology to mature earlier and live longer. Giant breeds lepsy' are not identical. Seizures are signs of dis­ would be required to cover the subject. There have mature more slowly and their average lifespan is ease. Dogs w1th true epilepsy have seizures as part been many reports of "epidemics" of tapeworms shorter. of an as yet undefinable disease. The American which do not respond to treatment. It's surprising In animals. including dogs, the teeth can be a Canine Epilepsy Service has been established to how many owners don't understand the problem. guide in determining the age. Puppies have no teeth study the disease. Wo rming the dog is only part of the solution. at birth. but the baby teeth come in at three to four

Dr. Michael H. Goldschmidt's topic was Cancer weeks. At four to five months of age, the permanent in the Dog. Diagnosis is by microscopic examination ldentlfication. A photograph might help identify a dog teeth come in. After about one year of age, the of tumor tissue which helps determine if the tumor is if there are unusual markings, but describing a ''losf' amount of wear is an Indication of age, but there is benign or malignant (life-threatening). The most fre­ dog can be difficult especially when so many breeds so much variation in individuals, it becomes a guess­ quent sites of growths submitted to the Pathology appear identical-Black Cocker Spaniels for exam­ ing game. A dog is considered a puppy until it is one Laboratory at the University of Pennsylvania, School ple. Tattooing is a way to be sure a dog can be cor­ year old, so the teeth can do little more than indicate of Veterinary Medicine, are skin and connective rectly identified. Usually a number is placed on the whether or not it Is puppy or adult. hairless skin of the inner hind leg. It lasts a lifetime. Another advantage is positive identification of show dogs. It might be difficult to find where proper equip­ ment is availaule but tattooing is being done and is a simple procedure.

Spring 1983 11 99 Down-1 to Go!

Immediately after the death of Dean Raymond A. Before becoming dean, Dr. Allam had already The matter of recruiting a larger, better trained Keiser in April 1952, Or. Mark W. Allam was called to developed some close. lasting friendships with impor­ faculty was a slow, difficult process. Since its incep­ the office of the President of the University and tant individuals in the university. These included Or. tion. in 1884, the School had largely depended upon asked whether he would accept an appointment as Isadore S. Ravdin, vice-president for medical affairs, its own graduates to staff its faculty. While this pro­ acting dean of the Veterinary School. He accepted, Dr. A. Newton Richards, and Dr. Robert Dripps. cess resulted in the appointment of some excellent in­ and served in this capacity until February 1953 when Through these and other individuals the Veterinary dividuals who were the backbone of the School for he was appointed dean. Dr. Mark Whittier Allam was School began to receive support from the University many years, this inbreeding process also resulted in the eighth dean of the School. in many areas that were important to its future. a faculty lacking individuals with advanced training Although there had been some real progress On the advice of Dr. Alexander Webb, an influen­ and rather parochial in its views. Following World under Dean Keiser, the new dean inherited a school tial alumnus, Dean Allam joined various agricultural war II most veterinary schools began to undergo which had severe problems. In fact. soon after he organizations. attended their meetings and carried some pronounced changes; other schools were devel­ was appointed dean Dr. Allam posed the critical the message that the Veterinary School intended to oping faculties with larger numbers of individuals question of whether the School could. or should. sur­ provide Pennsylvania with the very best in veterinary who had done graduate work and were expanding vive. This question was asked of a small group of medical service, research, and education. Many of their research programs. The Veterinary School at faculty, and after much soul-searching a decision these groups become loyal supporters of the School, Penn suffered by comparison, especially in its re­ was reached that an all-out effort should be made, and this. along with Dean Allam's persuasive educa­ search activities. A saving feature at Penn was the not only to solve the problems, but to put the School tion of state legislators about the potential contribu­ presence, in the early 1950s, ot a small nucleus of on a pathway to future greatness. Considering the tions of the Veterinary School, led to a progressive faculty who had begun some major research. Particu­ problems at hand, this was a brave decision. increase in Commonwealth appropriations. larly noteworthy were Or. David K. Detweiler and Dr. At the time the following were recognized as be­ Soon after Dr. Allam became dean he was able John T. McGrath; Dr. Evan L. Stubbs was continuing ing imperative to the School's future: The image of to obtain some funds from the University to renovate his outstanding research on poultry diseases. Dean the School in the University family must be greatly portions of the Small Animal Hospital and by 1955 a Allam set about attracting faculty from other institu­ improved; the School must win the support of impor­ Faculty Study Group was diligently at work develop­ tions and also from among Penn graduates who had tant agricultural groups in Pennsylvania and use ing plans tor a new basic science building on the a desire tor advanced training. An importan1 feature this, and other support, to obtain increased appropri­ Philadelphia campus. This structure, completed in in this building process was that individuals on the ations from the Commonwealth; the physical plant 1963 and known as the Rosenthal Building, not only Veterinary School faculty were able to engage in must be renovated and expanded; the faculty must provided the School with urgently needed space for graduate work in the Faculty of Arts and Sciences be upgraded and enlarged; the relationship of the research. teaching and a library, but also marked a and in the Graduate School of Medicine. Through this School to its alumni and the private sector needed turning point in the School's relationship with the process. and the attraction of individuals who had al­ great improvement. All of this would require consid· Commonwealth. To construct this building, the Penn­ ready established themselves. a strong cosmopolitan erable time, but under the energetic and astute guid­ sylvania State General Authority. through its General faculty was developed. ance of Dean Allam a beginning was made in all of State Authority, provided a S2.2 million loan. At the One essential step in the renaissance of the these problem areas. An essential feature in the time, Dr. Allam recalls, those who had been advocat­ School was the acquisition of a rural campus, New renaissance program would be the wholehearted sup­ ing a veterinary school at Penn State University Bolton Center, in 1952. At that time the Veterinary port of the faculty, In fact. the next three decades "backed off." School was in danger of losing its accreditation be· were a period in which the faculty came together as cause of the very low clinical load of farm animals a cohesive, productive unit. and horses. New Bolton Center provided the means of answering this problem. More about this in the next issue.

• • • • • A �atJOJl tl t\,,,tr l Bellwether has won a national award from the Dog Writers Association of America (DWAA). This award, made hy the DWAA al their annual banquet and meeling in New York City on February 13. 1983, was in the category of Special Jnterest AnimaJ Magazines. Last year Bellwether received a national CASE award.

fJr. Mnrlr rl". Alfam

Bellwether 12 Student Chapter of the American Veterinary Medical Just in Time for Association (SCAVMA) Christmas

The members of the Student Chapter of the On December 25, 1982 between 9:30 and 9:45 In the wild, goriUas live in groups with as American Veterinary Medic::al Association a.m. the Philadelphia Zoo received a very spe­ many as twenty to thirty members. Their he· (SCAVMA) at the School of Veterinary Medi­ cial Christmas gift: a baby male gorilla. Measur· havior is learned through three steps of sociali· cine, University of Pennsy lvania, elected the ing approximately two feet and weighing three zation: maternal, parentaJ, and juvenile, and following officers for 1982-1983: and a half pounds, the infant is the second the group is integral in the learning process. President: .lim Lnnig gorllla to be born at the Zoo in the last two Captive animals are often separated from each Vice President: Amy Wo rrell years. A female, Jessie, was born in 1980. other, consequently, they must be taught be· Secretary: Cathy C'..atanzaro For almost a month the new gorilla was havior patterns concerning copulation and Treasurt!r: Holly Leather nameless. But in late January a name was se­ infant care. The faculty adviser is Dr. David Kowalcyk, lected from among 12,000 entries in a contest Snickers, Samantha, and John arrived at assistant professor of pharmacology and co-sponsored by The Daily News and the Phila­ the Zoo along with two other males, To hy and toxicology. delphia Zoo. Mrs. Joan Velosk.i of Drexel Hill Bobby, in 1969. At that time the Zoo became SCAVMA and its anxiliary, each ye,ar, spon· entered the winning name, Justin, because the interested in the 1 reatn1ent of primates in cap­ sor a number of events. These include: a fall baby was "j ust in time for Christmas."' Mrs. tivity. It was impo�ible to duplicate the envi· and spring picnic, a square dance and a dinner Veloski will be present at Justin's public debut ronmcnt of the wild gorilla in the Rare Mam· dance, hoagie and T-shlrt sales to raise money in early Fcbmary. mal Honse where the gorillas were housed. for financing student delegates to attend the Justin and JeetSie share the same father, The facilities are poor and the cages are too annual symposium �ponsored by the national John, however. their mothers are different. smaJI to foster much group interaction. Yet Dr. association of SCAVMA, guest Lecturers for Jessie's mother is Samantha and Justin's is Robert Snyder, Director of the Penrose Laho· monthly meetings, an auction and raffle to Snickers. Snickeri'l, who suffers from arthritis ratory, believed that some aspects of the social raise money for the Student Emergency loan and is part.1ally paralyzed on her right side, group should and could be reconstructed. He fund. gave birth to a stillborn infant in 1974. Last especially stresHed the importance of a close Students joining SCAVMA have the follow· year doctors performed tests on her tn deter­ mother/infant relation�ship. Each animal was ing benefits: immediate membership in the mine fertility, and during the second test they placed with a surrogate mother (a zoo keeper) American Veterinary Medical Association discovered her pregnancy. According to keeper, who remained with the gorilla seven days a (AVMA) with a waiver of dues for the first Patti Kuntzmann, Snickers's labor was short week for three yearH. All of the gorillas also year and reduced dues for the next two years and the birth was n�lativcly painles�. Mother ate and played together in their early years of membership; reduced subscription rates for and infant will share the same cage as Snickers under the guidance of animaf specialists. the AV.MA Jou.mnl. and the American Journal is expected to nurse Justin for six months to a Currently the goriJias are in a stage of in­ of Ve terinary Research. access to the AV MA year. Snickers was pre!!ent during Jessie's birth termittent experimental progress. A new pri­ Auxiliary Student Lc'>an Fund for juniors and and for the past nine months she has spent mate center, rlesir;med by the Philadelphia senior�. group l£:rm Jife insuranl'e policies, and time watching the interaction hetween firm, Ven turi, Rauch and SC'ott Brown, is malpractice inRurancc which is available for Samantha and Jessie. under con!-ltrnclion and should be finished by students in externsrups and preceptorships, 1986. It is huped that the new facility will en­ placement service for senior !!tudents, assis· able the gorillas, Ju!'llin and Jessie included, to tance for obtaining speakers, and access to a £orm a gorllla nucleus and to interact with film library. each other e"·cn more clmely. nwhcr� holds her "' '" l11•rn furll,\ !11�1111 Continuing Education Program

The final continuing edu<'ation program for the 1982-1983 calendar year, Health and Eco· nomic Pr.ogram !ii for the Large J>iary Herd, will be held on Wednesday, May 18, 1983, at the Baltimore Hilton Inn at Reisterstown Road in Baltimore, Maryland. Dr. Kenneth Braun, Professor of Preventative Medicine, from the llniv<'rsity of Florida Sehoul of Veteri­ nary Medicine; Dr. Lawrence Heider, Professor of Preventative Medicine, from the Ohio State Universit}' School of Veterinary Medicine; and Dr. John Fetrow, A.!'sociate in Animal Health E<'onomics, from the University of Pennsylva­ nia School of Veterinary Medicine will discuss nutritional consultatio�, reproductive pro­ grams, mastitil:l control programs, record sys­ tems, and practice economic�< in large dairy herds. This course is co-sponl-lored by the Uni­ versjty of Maryland, the Unh·ersity of Pennsyl­ vania, and Penn State Univer�ity.

For further irtformation and registration plea11e contact: Ashra Markowitz, UnitJersity of Pennsylvania, School of Ve terinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104; or call (21.5) 8984234.

Spring l983 ]3 Phoro by the Phi.ladelphm Daily News Rosettes & Ribbons

Congratulations to the Congratulations to Scott was recently appointed will present two papers. of medicine make Bill Kennel Club of Philadelphia 0. Moron a senior student to the Board of Directors one at the International Boucher an outstanding on their highly success­ who was named recip­ of the Leukemia Society Physiological Congress, role model for all of us ful dog show held on ient of the newly estab­ of Southeastern Pennsyl· and the other at a satel­ fortunate enough to have December 18, 1982. There lished Bide-A-Wee long­ vania and treasurer of lite meeting of the been his students.·· were over 2.500 entries Sondheimer Scholarship, the Philadelphia Region Congress. in the 88th annual show. Scott is a native of of the Martin Luther Dr. Roselyn Eisenberg. as­ Massapequa, Long King, Jr., Center for Non­ A new text titled, Current sociate professor of Dr. Peter Hand. professor Island. He was listed in Violent Social Change of Th erapy in Equine Medi­ microbiology at the Veter­ of anatomy, recently pre­ the 1974 edition of Who's Atlanta, Georgia. cine (W. B. Saunders Co., inary School. and Or. sented a talk at two loca­ Who in American Junior Philadelphia, 1983) has Gary Cohen, professor of tions in Taiwan. The talk Colleges, and in 1979 On February 8 and 9, been dedicated to Dr. microbiology at the Den­ was entitled "An autoradi­ was a Mark Morris Ani­ 1983, William Ellsworth William Boucher. emeritus tal School, have received ographic deoxyglucose mal Foundation Fellow. Jones. the New York cor­ professor of medicine. a grant from the Lederle study of some central ef­ The Bide-A-Wee Long­ respondent for the The dedication reads as laboratories of the fects of acupuncture." Sondheimer Scholarship Sunday Times of London follows: "High standards American Cyanamid Cor­ This was presented first is made possible by a visited New Bolton Cen­ of professional integrity, porations to conduct at the plenary sessions legacy received for the ter. The Times is produc­ careful clinical observa­ research on developing a of the First International overall purposes of Bide­ ing a "magazine" on tion, humane concern for vaccine against herpes. Symposium on Acupunc­ A-Wee toward the better­ racehorses that will be the patient, an aware­ Drs. Eisenberg and ture and Moxibustion ment of animals in released at the start of ness of the owner's re­ Cohen have been collab­ held in Taipei on general. Two full scholar­ the English racing sea­ quirements of the animal. orating on this work for November 19-21, 1982, ships are provided son. Plans call for a and a broad knowledge the past six years. and then on November annually to senior veter­ separate article about 23 at Taichung. inary students-one at New Bolton Center. focus­ • Penn. and one at Cornell. ing on the advances in done by students Dr. Peter Dodson, associate Bide-A-Wee, founded in surgery now available to Help For from the Dental professor of anatomy 1903, is a nonprofit ani­ save injured racehorses. School. Actually the {paleontology} was mal welfare organization Epilepsy work was done by awarded a grant by the whose primary function Dr. Samuel K. Chacko, pro­ Dr. Carl Tinkdman, Board of University of is finding new homes for fessor of pathology, was A new booklet titled assistant professor. of Pennsylvania Research dogs and cats. It also awarded a Senior Re­ Ep ilepsy in Dogs has endodontics at the Foundation for a project provides veterinary clin· search Fellowship from been published by the Dental School. titled "Comparative anal­ ics and pet memorial Fogarty International Cen� American Canine Epi· In report1ng on ysis of a new small parks. ter of the National Insti­ lepsy Serv1<�e under the chain; in the Vet­ horned dinosaur." Or. tute of Health. During the the diredion of Dr. erinary School we Dodson was the subject Dr. Alan Klide, associate tenure of this fellowship, George F arnbach, as· omitted the Richard of a recent story in The professor of anesthesia, D(. Chacko will perform sistant professor of King Mellon Profes· Philadelphia Inquirer. The had an active lecture collaborative research on neurology. This is con­ !I!Orship of Repro­ dinosaur in question schedule in 1982. In Feb­ the biochemical regula­ cise review of the ductive Physiology dates back 75 million ruary he spoke at the tion of arterial smooth problems of epilepsy oecupied by Dr. Ralph years and Or. Dodson de­ School of Veterinary muscle with Professor in dogs and contains L. Brinster. scribes it as "an extreme­ Medicine. Guelph. Can­ Setsuro Ebashi, Univer� the following sections: ly rare, small horned ada on "Anesthesia for sity of Tokyo. The collab­ What is Epilepsy?; dinosaur that doesn't fit Exotic Species," and at orative research is ex­ What Causes Sei· Resource the public's conception the Ontario Veterinary pected to provide insight zures?; How Harmful that dinosaurs were Association Conference into the regulatory mech­ Are Seizm·es?; Is Update: huge species." The small on "Theory and Equip­ anisms by which the arte­ There a Treatment horned dinosaur was ment for Veterinary Acu­ rial walls from normal for Canine Epilepsy?; VHUP about four feet long and puncture in Horses: Prac­ and hypertensive individ­ What Anticonvulsant In addition to the two feet high. Dr. Dodson tical Application." In uals contract and relax. Will Work for My Wildlife Services of­ points out that "if there May, Or. Klide spoke on Dog?; and What is the fered by VHUP, there were people around ''Veterinary Acupuncture'' Dr. Richard Mlsells. associ· Role of the Canine is also an Exotic Pet then-which there at the meeting of the ate professor of anat­ Epilepsy Service? If Clinic one evening a weren't-this dinosaur Western New York Veteri­ omy, was also awarded you are interested in week. Appointments would have been com­ nary Association. a Fogarty Fellowship, receiving this informa­ can be made by ca 11- pletely harmless and inof­ and will spend seven tive booklet, contact ing (215) 8984680. fensive." The bones were Dr. Robert J. Rutman. pro­ months at the Flori lnsti· Dr. Farnhach, Veteri­ The clinic days discovered in 1981 in fessor of biochemistry, tute of Experimental Med· nary Hospital of the for Orthopedics have central Montana. icine. Melbourne. Austra­ University of Pennsyl­ been f:hanged to Tues­ lia where he will conduct vania, 39th and days and Fridays. Ralph E. Werner. Jr. (V'68), neuroanatomical and Spruce Sts., Philadel­ This section only recently became a diplo­ physiological studies on phia, PA 19104. accepts appointments mate of the newly water balance in sheep. after the referring formed American Board This is an extension of veterinarian contacts of Veterinary Practition­ his current work on labo­ Errata the Small 'Animal Hos· ers. Dr. Werner practices ratory animals and will In the last issue we re­ pital to explain the in Somers Point. N.J. include the use of immu­ specifics of the <�ase. noassay methods. While ported that the dental work on the Siberian in Australia Dr. Miselis tiger, Kundur, at the Philadelphia Zoo was

Bellwether 14 \ tcrt11ar' ledical r·ttnti t Tr · ining t ogran1

For many yean the SchooJ of Vet erinary Medi· cine has been a major supplier of academic sci· enlists and faculty for other veterinary schools May 14 18 19 as well as for medical school!! and universities. Helmlnthologlcal Society of *Health and Economic Board of Overseers Meeting In 1969 the training of one group of these sci· washington Meeting Programs for the Large New Bolton Center enlists, those studying for both a V.M.D. and a New Bolton Center Dairy Herd Ph.D., received national recognition by the Baltimore Hilton Inn award of a training grant from the National Baltimore. Maryland Institutes of HeaJth. The program was at that 9:00 a.m.-5:00 p.m. time, and still is, the only V.M.D./Ph.D. train· ing program at a School of Veterinary Medi· cine to compete succeAAfully for such support. About twenty medical schools, including Penn, have such training grants but many other med· 21 23 Commencement icaJ schools ha,•e not been sue:ccssful in ob· Alumni Day taio.ing this type of training grant support. New Bolton Center Thus, our program continues to be highly com· petitive with those at the best research· intensive medical schools. Fh·e years ago the veterinary program and medical programs were merged into one administrative unit since training was quite similar in many parts of both. The plan for the conting five years will not see major shifts in direction in this pro· June 2 26 gram since it has been very effective during New Bolton Center Reunion, Class ot 1963 the past thirteen years. However, gradual modi­ Retirement Dinner New Bolton Center fications will be instituted to take advantage of our growing experience with training oppor· tunities and [eedback from graduates. Basical­ ly our plan is to appoint two or three trainees tm<'b .veaL· fr·om entering students or the first· year dass. The competition is intense with about forty surerlative applicants competing for the position!l. The suc.r.essful applicants wiU July 19 then follow a combined V. M.D./Pb.D. program AVMA National Meeting full time for six to seven years. Each trainee Alumni Reception has an individually tailored course of study New Yo rk, NY based on providing the bert foundation for the lltudent's chosen career goal. It is anticipated that the graduates of this program wi II enter academic medicine and staff the faculties of ·continuing Educat;on schools of veterinary medicine and science de­ Credit partments in medical Hchools, They will be superbly qualified to bridge the gap between 3 • � $ • �::. II i:• basic science and clinical departments, bring· cology and $17,200 for our research in canine Thoroughbred Rtallion REAL SUPREME to ing knowledge of health problems into basic epilepsy (see Bellwether 4). New Bolton Center, and Lam:mont Farms do­ science labor·atorieli and knowledge of basic The American Livestock Insurance Com­ nated the Standardbred stallion WESTWARD science investigative puwer into clinical medi­ pany and Harding and Harding, Inc., of to the Hofmann Research Center for Animal cine. Already the graduates of this program Geneva, Dlinoil'i, granted $7,500 to support Dr. Reproduction. have been enormously successful and are high· Loren Evans' work in laminitis, and the Basset The oil painting, Endangered Species, by ly sought after upon graduation. We regard Hound Club of America granted $1,000 to Dr. Tucker Bobst was given to the Ve terinary Hos· this as one of ouT elite program!'! that greatly Vicl.i Meyer� to continue her work in canine pital by Richard Maloy and now hangs in the enriches the School and contributes some of pyometra. ho!lpital's Clark Pavilion. our most gifted and highly trained graduates The Delaware County Kennel Club (PA) The Pennsylvania Society for the Preven· to the profession and to academic life. During gave the Ve terinary Hospital $3,000 toward the tion of Cruelty to Animals contributed 810.000 the coming five years we expect to graduate purchase o( equipment to computerize the for student loans, and the Ware Foundation two to three individuals per year from this medjcaJ records system in the Small Animal granted $8,000 toward our program in ovine program. Hospital, and the Montgomery County Kennel medicine al New Bolton Center. Club (PA) gave us another $1.750 toward this The Richard King Mellon Foundation project. awarded the School a major grant of $250,000 ) Ill II11 t 1., The Devon Dog Show Association (PA) con­ to provide operational endowment for the Lab· tributed $3,500 to the Friends of the Small oratory of Reproductive Physiology and At the end of the first seven months of the fis· Animal Hospital, and the Empire Cat Club Genetic Engineering under the direction of Dr. cal year, 390 donors b.ad contributed S69,952 to (NY) joined the Friends of the Small Animal Ralph Brinster, the Richard King Mellon Pro· Annual Giving. The Friends of Small Animal Hospital with a gift of $1,500. fesso.r of Reproductive PhyHiology. Hospital had 742 member� contributing $41,970 The Firestone Foundation granted $20,000 Two anonynlOUA giftA totalling approxi· and 99 Friends of New Bolton Center contrib­ t.o Dr. Loren Evans for his work on an im· mately $201000 were given for the renovation uted $32,450. proved table fo1· large animal surgery, and the project now undet' way in the Old Small The American Kennel Club has awarded fonndation granted an additional $100,000 to Animal Hospital, and another anonymous gift us a u;rant of $20,000 for our work in canine on- New Bolton Center as part of its recent deci· of juHt under $.10;000 was gi"·en to the Friends sion to liquidate its assets. of the Small Animal Hospital. Mr. and Mrs. Philip B. Hofmann gave the Spring 1983 15 The Veterinary Class of 1952 was the 1983 recipient of the "Award of Merit" of the Organized Classes of the University of Pennsylvania Recognizing the Uni­ versity alumni class which has exhibited outstanding qualities of solidarity and allegiance to U1 eir School and the University, the award has been presented an­ nually since 1957. At the January 21 dinner of The Organized Classes. Rosemary Mazzatenta. chairper­ son of the Awards Commttlee. presented the award plaque to Drs. John E. Whitehead, class president, and Loy C. Awkerman, class agent Noting that thts was the first class of the School of Veterinary Medi­ cine to recetve the award, Ms. Maua1enta pra•sed the Class of 1952 for its outstanding partic•patlon tn Veterinary Alumni activities, communication among class members. and financial support of the School and Universtty through Annual Giving. The class has an average of 65 percent parttcipation rn Annual Giv­ ing each year. "a performance challenging all classes in all schools," according to Ms Mazzatenta.

Bellwether

University of Pennsylvanra Non-Profit Organization School of Veterinary Medicine US Postage 3800 Spruce Street PAID Philadelphta. PA 19104 Philadelphra. PA Permit No 2147