Table 7. Distance and frequency of amino acid polymorphisms

Type of Physiochemical Obseved frequency** / Amino acid pair mutation distance* expected frequency**

Alanine Threonine Transition 58 1.46 Alanine Valine Transition 64 0.92 Arginine Cysteine Transition 180 0.41 Arginine Glutamine Transition 43 0.98 Arginine Glycine Transition 125 0.43 Arginine Histidine Transition 29 1.03 Arginine Lysine Transition 26 1.33 Arginine Tryptophan Transition 101 0.22 Asparagine Aspartic acid Transition 23 1.44 Asparagine Serine Transition 46 1.62 Aspartic acid Glycine Transition 94 0.58 Cysteine Tyrosine Transition 194 0.33 Glutamic acid Glycine Transition 98 0.58 Glutamic acid Lysine Transition 56 1.14 Glycine Serine Transition 56 1.14 Histidine Tyrosine Transition 83 0.96 Isoleucine Methionine Transition 10 1.47 Isoleucine Threonine Transition 89 0.73 Isoleucine Valine Transition 29 2.25 Leucine Phenylalanine Transition 22 0.48 Leucine Proline Transition 98 0.35 Leucine Serine Transition 145 1.13 Methionine Threonine Transition 81 1.09 Methionine Valine Transition 21 0.97 Phenylalanine Serine Transition 155 0.51 Proline Serine Transition 74 1.03 Alanine Aspartic acid Transversion 126 0.57 Alanine Glutamic acid Transversion 107 0.79 Alanine Glycine Transversion 60 0.95 Alanine Proline Transversion 27 0.80 Alanine Serine Transversion 99 2.46 Arginine Glycine Transversion 125 0.31 Arginine Isoleucine Transversion 97 0.58 Arginine Leucine Transversion 102 0.39 Arginine Methionine Transversion 91 0.46 Arginine Proline Transversion 103 0.35 Arginine Serine Transversion 110 0.68 Arginine Threonine Transversion 71 0.58 Arginine Tryptophan Transversion 101 0.16 Asparagine Histidine Transversion 68 1.57 Asparagine Isoleucine Transversion 149 0.60 Asparagine Lysine Transversion 94 1.12 Asparagine Threonine Transversion 65 1.66 Asparagine Tyrosine Transversion 143 0.55 Aspartic acid Glutamic acid Transversion 45 2.24 Aspartic acid HistidineTransversion810.47 Aspartic acid Tyrosine Transversion 160 0.30 Aspartic acid Valine Transversion 152 0.36 Cysteine Glycine Transversion 159 0.46 Cysteine Phenylalanine Transversion 205 0.37 Cysteine Serine Transversion 112 0.73 Cysteine Tryptophan Transversion 215 0.19 Glutamic acid Valine Transversion 121 0.45 Glutamine Glutamic acid Transversion 29 1.31 Glutamine Histidine Transversion 24 1.32 Glutamine Leucine Transversion 113 0.58 Glutamine Lysine Transversion 53 1.57 Glutamine Proline Transversion 76 1.04 Glycine Tryptophan Transversion 184 0.27 Glycine Valine Transversion 109 0.36 Histidine Leucine Transversion 99 0.45 Histidine Proline Transversion 77 0.80 Isoleucine Leucine Transversion 5 1.72 Isoleucine Lysine Transversion 102 0.57 Isoleucine Methionine Transversion 10 1.16 Isoleucine Phenylalanine Transversion 21 0.57 Isoleucine Serine Transversion 142 0.50 Leucine Methionine Transversion 15 1.84 Leucine Phenylalanine Transversion 22 0.88 Leucine Tryptophan Transversion 61 0.45 Leucine Valine Transversion 32 1.15 Lysine Methionine Transversion 95 0.52 Lysine Threonine Transversion 78 0.84 Phenylalanine Tyrosine Transversion 22 1.90 Phenylalanine Valine Transversion 50 0.56 Proline Threonine Transversion 38 0.89 Serine Threonine Transversion 58 2.37 Serine Tryptophan Transversion 177 0.28 Serine Tyrosine Transversion 144 0.49 * Distance is measured with the Granthem matrix. ** Only includes amino acid changes caused by a single nucleotide change.