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The Science of Malaria Eradication

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The Science of Malaria Eradication Scientific Organizers: Pedro L. Alonso Chetan E. Chitnis Welcome from Board Chair and CEO ................................. 2 Lee Hall Maximizing Your Meeting Experience ............................... 3 Program ..........................................................................4 Meeting Support ............................................................. 11 Organized in collaboration with: Scholarship Recipients .................................................... 12 MESA – Malaria Eradication Meet the Scientific Organizers ........................................ 15 Scientific Alliance About Keystone Symposia ............................................... 16 Donor Acknowledgement ............................................... 19 Speaker Abstracts........................................................29 Part of the Keystone Symposia Poster Abstracts ...........................................................43 Global Health Series Author Index ................................................................... 70 supported by the Participant List ................................................................ 73 Keystone Symposia Staff ................................................. 77 Bill & Melinda Gates Foundation Board of Directors, Scientific Advisory Board and Programming Consultants ....................................... 78 February 2–7, 2014 Policies ............................................................................ 81 2013–2014 Keystone Symposia Meeting Series ............. 82 Fiesta Americana 2014–2015 Keystone Symposia Meeting Series ............. 84 Mérida, Yucatán, México Visit keystonesymposia.org/14F1 Unless otherwise noted, the information in this book is current to view the meeting program online. as of January 14, 2014. If you registered after this date, your name is included in an online list accessed from attendees’ Twitter hashtag for this meeting: #KSmalaria Keystone Symposia accounts. Please be advised that no video equipment, cameras, audio equipment or any other type of recording device will be allowed in the meeting room or poster sessions. Full meeting policies are on page 81. Keystone Symposia is a 501(c)(3) nonprofit organization directed and supported by the scientific community. [email protected] | www.keystonesymposia.org This book is printed on 30% post-consumer recycled paper Welcome Dear Keystone Symposia Meeting Attendee, Thank you for joining us as we convene the Keystone Symposia conference on The Science of Malaria Eradication. We’re sure you will enjoy the days you spend here in Mérida absorbing the latest and most exciting research in the company of the like-minded – both those you may know very well and those you will meet for the first time. This is one of 58 conferences Keystone Symposia has scheduled for the 2013-2014 meeting season. Not included in that number is Keystone Symposia’s first-ever virtual event – on “HIV/AIDS: Strategies for an Endgame” – in December 2013, a milestone for the organization. While more of these online events will bring science to a broader global audience, nothing can quite replicate the value of a face-to-face meeting like this one, and we hope you will make the most of it. Along these lines, please take advantage of the newly enhanced and redesigned Keystone Symposia mobile app to connect with colleagues and make new connections. New this year, you will be able to read poster and speaker abstracts on the app, as well as send messages directly to specific participants. You can also take notes on the sessions and abstracts, “favorite” sessions you don’t want to miss, and learn more about the local area. If you haven’t already, be sure to upload your photo and profile to the app so that other attendees can more easily recognize you. Please complete the survey when you receive the link just after the conference concludes. Your input is extremely valuable to assist us in continuously enhancing the scientific content and format of our meetings. We sincerely hope you enjoy this Keystone Symposia conference and return for many more. Best wishes, Juleen R. Zierath, Ph.D. Professor of Molecular Medicine and Surgery, Karolinska Institutet Chair of the Board, Keystone Symposia Dear Meeting Participants, Thank you for choosing to attend. Our highest priority is to provide the most stimulating meeting programs and environment for sharing data, generating ideas, starting collaborations, and maybe launching life-long collegial relationships. In doing these things, we also strive to add value to the training of the next generation of scientists. In spite of the continuing worldwide economic troubles, which may affect some scientists’ ability to attend, we are gratified that many do continue to engage in this vital face-to-face debate of the scientific challenges facing the world. Our meeting participation is also becoming more global in reach. In 2013, participants came from 92 countries, including 19 African, 14 South or Latin American, and 25 Asian or Asia Pacific countries. Eleven years ago, the year before I joined Keystone Symposia, participants came from 64 countries. During those years, the number of participants from the USA increased by about 5%, while non-USA participation increased by 80%. In 2012, 43% of all attendees came from outside the USA and in 2013 non-USA attendance was closer to 46%. These simple numbers just hint at the intricacy of the present era of science globalization. We will continue to expand our global programs; in 2013 we held our first two conferences in South America (Rio de Janeiro and Ouro Preto, Brazil). Dr. David Woodland has completed his second year as Chief Scientific Officer. Woody has moved quickly to ensure the continuing high quality of the conferences. Quality in programming is highly dependent on feedback from attendees, so please be generous with comments, either good or bad. The CSO, Scientific Advisory Board, and Scientific Organizers integrate feedback to generate a portfolio of annual meetings that we hope will energize the scientific community. We greatly value the financial support of corporations, foundations, governments and individuals. Keystone Symposia does not have an endowment, so this continuing diverse base of support on an annual basis is vital. Through generous donations, we are able to defer some of the expenses of many deserving early-career scientists and also offset many of the costs we would otherwise have to pass on to attendees. I hope that your experience at this conference is valuable and memorable and that you will spread the word to others who might benefit from what you learn. Sincerely, James W. Aiken, Ph.D. President and Chief Executive Officer, Keystone Symposia 2 Maximizing Your Meeting Experience Meeting Format The conference program has been designed around Keystone Symposia’s mission: to accelerate life science discovery by providing a forum to present top-quality science, foster new collaborations and help prepare the next generation of life scientists. Poster Abstract Sessions Poster sessions play host to some of the most dynamic interactions that take place at our conferences and are not to be missed. Abstracts have been numbered by session: abstracts presented during Poster Session 1 are numbered in the 1000s, Poster submitted poster abstracts. These oral poster abstract presentations may or may not fall on the same day as the presenter’s Session 2 in the 2000s, etc. Scientific organizers have selected short talks for plenary sessions and sometimes workshops from corresponding poster abstract section of the book. (Note: Plenary session speakers are numbered in the hundreds: day one posterspeakers session. are the If 100s, you areday a two presenter, speakers please are the check 200s, the etc. index Speaker to find abstracts your abstract are located number; before your the abstractposter abstracts will appear in this in thebook. ) To make the most of the formal poster sessions, we encourage you to preview posters during the time slots marked for informal poster abstract viewing. Enjoying the Location Please be aware of your environment as you plan your free-time activities. If you are at a high-altitude meeting, we urge you to that Keystone Symposia and venue staff may have arranged. rest on your first day and drink plenty of water. Check the bulletin board for group outings and other activities and discounts Meals The meals included in your registration vary by site. Check the program for meals marked “On Your Own” and plan accordingly. Meals listed with a time and place are provided as part of your registration. Some attendees choose to make a meal out of “Lite Bites.” Abstract Books and Online Resources With the anticipation that digital delivery of conference materials will eventually supplant print, Keystone Symposia staff is free to return this printed abstract book to the registration desk. Inworking further to efforts provide to youcut backwith onmulti-platform waste, we have access also to replaced all conference the notepads information. provided If you in the find past you with prefer extra the note-taking digital formats, pages feel in the back of this book. Our staff has also been working hard to consolidate the abstract book to reduce the total number of pages. We anticipate this will save roughly 400,000 sheets of paper this meeting season! Digital Abstract Book from Your Account You may download a PDF of this book from your Account on our secure website beginning seven days before the meeting
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  • Actin Is an Evolutionarily-Conserved Damage-Associated Molecular

    Actin Is an Evolutionarily-Conserved Damage-Associated Molecular

    RESEARCH ARTICLE Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster Naren Srinivasan1†, Oliver Gordon1†, Susan Ahrens1‡, Anna Franz2, Safia Deddouche1§, Probir Chakravarty3, David Phillips4, Ali A Yunus5, Michael K Rosen5, Rita S Valente6, Luis Teixeira6, Barry Thompson7, Marc S Dionne8, Will Wood9, Caetano Reis e Sousa1* 1Immunobiology Laboratory, The Francis Crick Institute, London, United Kingdom; 2Department of Biochemistry, Biomedical Sciences, University Walk, University of Bristol, Bristol, United Kingdom; 3Bioinformatics, The Francis Crick Institute, London, United Kingdom; 4Genomics-Equipment Park, The Francis Crick Institute, London, United Kingdom; 5Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States; 6Instituto Gulbenkian de Cieˆncia, Oeiras, Portugal; 7Epithelial Biology Laboratory, The Francis Crick Institute, *For correspondence: caetano@ London, United Kingdom; 8Department of Life Sciences and MRC Centre for crick.ac.uk Molecular Bacteriology and Infection, South Kensington Campus, Imperial College 9 †These authors contributed London, London, United Kingdom; Department of Cellular and Molecular Medicine, equally to this work Biomedical Sciences, University of Bristol, Bristol, United Kingdom Present address: ‡Voisin Consulting Life Sciences, Surrey, United Kingdom; §Open Innovation Access Platform, Abstract Damage-associated molecular patterns (DAMPs) are molecules released by dead cells Sanofi Strasbourg, Strasbourg, that trigger sterile inflammation and, in vertebrates, adaptive immunity. Actin is a DAMP detected France in mammals by the receptor, DNGR-1, expressed by dendritic cells (DCs). DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk to promote DC cross- Competing interests: The presentation of dead cell-associated antigens. Here we report that actin is also a DAMP in authors declare that no invertebrates that lack DCs and adaptive immunity.