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Annual Report 2011-2012

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Annual Report 2011-2012 CONTENTS Director's Report ii 1. Releases of Monarda Citriodora Cerv. Ex Lag- A Rich Source of Thymol……......................................................................................01 2. Biodiversity and Applied Botany………….............................……….05 3. Plant Biotechnology…………………............................….………….09 4. Anti-Cancer Therapeutics..................................................................36 5. In Silico Biology…………………...…………………….………………50 6. Natural Product Chemistry (Plants)……….........................…………..52 7. Medicinal Chemistry…...………………………………….……………68 8. Fermentation Division….………..............…………………………….79 9. Enzymology and Biotransformations ….................…….…………….83 10.Microbiology…......……………………………………….…………….88 Publications……..………………………………………….……………….93 Patents…………………………………………………..........…………..98 Books and Book Chapters……………………………….………………....99 Seminars and Workshop………………………………….………………..99 Invited Talks………………………………………….....….………………100 Research Council……………………………………....………………….100 Management Council…………………………………..…………………101 Externally Funded Projects……………………,……….....………………102 Fellowships Awarded……………………………,…......…………………102 jktHkkÔk dh izxfr esa fgUnh ds dk;ZØe…………......….....................................105 Human Resource.....……………………………,…......…………………117 CONTENTS i 1. INDIAN INSTITUTE OF INTEGRATIVE MEDICINE, JAMMU RELEASES MONARDA CITRIODORA CERV. EX LAG- A DIRECTORS REPORT RICH SOURCE OF THYMOL I take pleasure in presenting this Annual Report of CSIR- Indian Institute of Integrative Medicine, Jammu which covers the highlights of the work carried during the year 2011-12. This year particularly remained very hectic where in several brainstorming sessions were held within the institute and in the presence of several invited subject matters experts to identify the programms and specific projects that institute focuss would during 12th Five Year Plan period. Several dignitaries visited the institute this year, prominent among themwas the visit of the Director General CSIR and Secretary to Government of India, Prof. S. K. Brahmachari who met Hon'ble Chief Minister of Jammu and Kashmir, Mr Omar Abdullah and the members of the Pharmaceutical Industry in Jammu region in connection with the programms on employment and revenue generation in the state. Hon'ble Chief Minister of Jammu and Kashmir, Mr Omar Abdullah also visted Institute both at Jammu and Srinagar and appreciated the work being pursued at IIIM. He also released the book entitled “Harnessing buiodiversity and biotechnology for progress of Jammu and Kashmir State” during the Scientific Advisory committee held in IIIM. Mr Omar Abdullah also laid the foundation stone of a modern GLP animal house in the campus of IIIM, Jammu. Hon'ble Parliamentary committee for the promotion of Hindi led by Sh Satyavrat Chaturvedi, Member Parliament visited the institute to have the assessment of the work being done by various central Government offices banks etc in Jammu region for the promotion of Hindi. The Hon'ble committee expressed it satisfaction on the efforts being made by IIIM to promote Hindi as official language. During this year the institute also released a new strain of hyper- productiveMonrada citradora Cerv. ex. Lag – A rich source of thymoldesignated as IIIM (J)MC-02 by following mass selection technique,. The major chemical constituent of this strain is thymol which ranges from 70- 85 % and has pleasant Trachyspermum ammi (ajwain) like fragrance. The following details in this report shall present to you the flavour of scientific work being carried out in the institute. Introduction Monarda citriodora Cerv.ex Lag.commonly known as Thymo-Herb belonging to family lamiaceae, is an important (Ram Vishwakarma) aromatic herb and a natural source of essential oil. The genus name is after Nicholas Monardes, a Spanish physician from Seville who wrote in the 16th century about New World Medicinal plants. The species name comes from Latin for “Citrus smell”. It occurs on limestone glades, rocky prairies in Missouri and ranges from Texas and Mexico north to Missouri and Kansus. Therefore the plants prefers light (sandy), medium (loamy) and heavy (clay) soils. It requires moist soil. The plant was introduced to judge its performance in terms of essential oil production and its quality characteristics under sub-tropical environment. ii 1 1. INDIAN INSTITUTE OF INTEGRATIVE MEDICINE, JAMMU RELEASES MONARDA CITRIODORA CERV. EX LAG- A DIRECTORS REPORT RICH SOURCE OF THYMOL I take pleasure in presenting this Annual Report of CSIR- Indian Institute of Integrative Medicine, Jammu which covers the highlights of the work carried during the year 2011-12. This year particularly remained very hectic where in several brainstorming sessions were held within the institute and in the presence of several invited subject matters experts to identify the programms and specific projects that institute focuss would during 12th Five Year Plan period. Several dignitaries visited the institute this year, prominent among themwas the visit of the Director General CSIR and Secretary to Government of India, Prof. S. K. Brahmachari who met Hon'ble Chief Minister of Jammu and Kashmir, Mr Omar Abdullah and the members of the Pharmaceutical Industry in Jammu region in connection with the programms on employment and revenue generation in the state. Hon'ble Chief Minister of Jammu and Kashmir, Mr Omar Abdullah also visted Institute both at Jammu and Srinagar and appreciated the work being pursued at IIIM. He also released the book entitled “Harnessing buiodiversity and biotechnology for progress of Jammu and Kashmir State” during the Scientific Advisory committee held in IIIM. Mr Omar Abdullah also laid the foundation stone of a modern GLP animal house in the campus of IIIM, Jammu. Hon'ble Parliamentary committee for the promotion of Hindi led by Sh Satyavrat Chaturvedi, Member Parliament visited the institute to have the assessment of the work being done by various central Government offices banks etc in Jammu region for the promotion of Hindi. The Hon'ble committee expressed it satisfaction on the efforts being made by IIIM to promote Hindi as official language. During this year the institute also released a new strain of hyper- productiveMonrada citradora Cerv. ex. Lag – A rich source of thymoldesignated as IIIM (J)MC-02 by following mass selection technique,. The major chemical constituent of this strain is thymol which ranges from 70- 85 % and has pleasant Trachyspermum ammi (ajwain) like fragrance. The following details in this report shall present to you the flavour of scientific work being carried out in the institute. Introduction Monarda citriodora Cerv.ex Lag.commonly known as Thymo-Herb belonging to family lamiaceae, is an important (Ram Vishwakarma) aromatic herb and a natural source of essential oil. The genus name is after Nicholas Monardes, a Spanish physician from Seville who wrote in the 16th century about New World Medicinal plants. The species name comes from Latin for “Citrus smell”. It occurs on limestone glades, rocky prairies in Missouri and ranges from Texas and Mexico north to Missouri and Kansus. Therefore the plants prefers light (sandy), medium (loamy) and heavy (clay) soils. It requires moist soil. The plant was introduced to judge its performance in terms of essential oil production and its quality characteristics under sub-tropical environment. ii 1 1.0 Plant Description 5.0 Therapeutic and General 6.3 Land preparation month of April-May at full 3.0 hours only. Field containers. The containers Uses Edible Use blooming stage. Rainy distillation units are should be air-tight and filled to It attains a height of 50-90 The land should be brought to periods should be avoided appropriate for small/medium the brim, and preferably stored cms. Leaves are 3 to 8 cm Edible part of the plant is fine tilth and laid out into plots for harvesting which resulted farmers in view of their low in dry, cold and dark condition. long, soft textured, lance leaves-raw or cooked. They of onvenient size depending in low essential oil recovery cost. shaped ending in a point are used as flavouring and upon the source of irrigation. It 9.0 Major chemical as well as poor quality of oil. and have a very strong and garnishing agent in salads, is desirable to add 10-15 tonnes 8.0 Storage constituents/Chemical It is estimated that on an pleasant Trachyspermum summer punches and as of farm yard manure per markers average 25-30 tonnes per Essential oil undergoes ammi (ajwain) like fragrance condiment in cooked foods hectare during the preparation hectare per year herbage was considerable changes in its The essential oil consists of when crushed. Flowers are and also used to make a of land and mixed properly in obtained. On an average, chemical composition during about eighteen chemical pink in color. refreshing lemon tea. It makes the soil. 100-125 kg of essential oil storage. On longer period of compounds identified and a lovely aromatic tea; its 2.0 Improved Variety 6.4 Transplanting obtained per hectare. storage, polymerization takes quantitated by GC/MS, out of flowers are edible. place resulting in decrease of which thymol (85 %) is the Following mass selection It is recommended to plant the 7.0 Distillation Medicinal Uses thymol content, thus major chemical constituent technique, a hyper- seedlings at 30x30 cm line to The essential oil is obtained adversely affecting the oil (Table 1). The essential oil of productive strain of Monarda Uses in colds, coughs, fevers,
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