Nuclear Medicine at the Hammersmith Hospital
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HISTORY Nuclear Medicine Begins with a Boa Constrictor
HISTORY Nuclear Medicine Begins with a Boa Constrictor Marshal! Brucer J Nucl Med 19: 581-598, 1978 In the beginning, a boa constrictor defecated in and then analyzed the insoluble precipitate. Just as London and the subsequent development of nuclear he suspected, it was almost pure (90.16%) uric medicine was inevitable. It took a little time, but the acid. As a thorough scientist he also determined the 139-yr chain of cause and effect that followed was "proportional number" of 37.5 for urea. ("Propor inexorable (7). tional" or "equivalent" weight was the current termi One June week in 1815 an exotic animal exhibi nology for what we now call "atomic weight.") This tion was held on the Strand in London. A young 37.5 would be used by Friedrich Woehler in his "animal chemist" named William Prout (we would famous 1828 paper on the synthesis of urea. Thus now call him a clinical pathologist) attended this Prout, already the father of clinical pathology, be scientific event of the year. While he was viewing a came the grandfather of organic chemistry. boa constrictor recently captured in South America, [Prout was also the first man to use iodine (2 yr the animal defecated and Prout was amazed by what after its discovery in 1814) in the treatment of thy he saw. The physiological incident was common roid goiter. He considered his greatest success the place, but he was the only person alive who could discovery of muriatic acid, inorganic HC1, in human recognize the material. Just a year earlier he had gastric juice. -
Regional Oral History Office University of California the Bancroft Library Berkeley, California
Regional Oral History Office University of California The Bancroft Library Berkeley, California University of California Source of Community Leaders Series Anne deGruchy Low-Beer Dettner A WOMAN'S PLACE IN SCIENCE AND PUBLIC AFFAIRS: 1932- 1973 With Introductions by Helene Maxwell Brewer and Lawrence Kramer Interviews Conducted by Sally Hughes and Gabrielle Morris in 1994 and 1995 Copyright @ 1996 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a modern research technique involving an interviewee and an informed interviewer in spontaneous conversation. The taped record is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The resulting manuscript is typed in final form, indexed, bound with photographs and illustrative materials, and .placed in The Bancroft Library at the University of California, Berkeley, and other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. All uses of this manuscript are covered by a legal agreement between The Regents of the University of California and Anne deGruchy Dettner dated April 20, 1995. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
Trustees' Annual Report and Financial Statements 31 March 2016
THE FRANCIS CRICK INSTITUTE LIMITED A COMPANY LIMITED BY SHARES TRUSTEES’ ANNUAL REPORT AND FINANCIAL STATEMENTS 31 MARCH 2016 Charity registration number: 1140062 Company registration number: 6885462 The Francis Crick Institute Accounts 2016 CONTENTS INSIDE THIS REPORT Trustees’ report (incorporating the Strategic report and Directors’ report) 1 Independent auditor’s report 12 Consolidated statement of financial activities 13 Balance sheets 14 Cash flow statements 15 Notes to the financial statements 16 1 TRUSTEES’ REPORT (INCORPORATING THE STRATEGIC REPORT AND DIRECTORS’ REPORT) The trustees present their annual directors’ report together with the consolidated financial statements for the charity and its subsidiary (together, ‘the Group’) for the year ended 31 March 2016, which are prepared to meet the requirements for a directors’ report and financial statements for Companies Act purposes. The financial statements comply with the Charities Act 2011, the Companies Act 2006, and the Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK (FRS102) effective 1 January 2015 (Charity SORP). The trustees’ report includes the additional content required of larger charities. REFERENCE AND ADMINISTRATIVE DETAILS The Francis Crick Institute Limited (‘the charity’, ‘the Institute’ or ‘the Crick) is registered with the Charity Commission, charity number 1140062. The charity has operated and continues to operate under the name of the Francis Crick -
Staff Changes Emma Bennett Joined the Academy As Exhibits Regularly in the UK and Europe
Council Election Nobel Prize Congratulations to the following Fellows who Dr Sydney Brenner were elected to serve as new members of FRS HonFMedSci was awarded The Council with effect from 21 November 2002. Nobel Prize in Physiology or Medicine for 2002 for his research into genetic regulation of organ development and Professor Carol Black programmed cell death. Though now based in California, President, The Royal College of Physicians and Professor of Sydney Brenner’s discoveries whilst working in Cambridge, Rheumatology, Royal Free and University College Medical School UK, laid the foundation for this year’s prize which was awarded jointly to H Robert Horvitz and John E Sulston. Professor Nancy Rothwell MRC Research Professor, University of Manchester Professor Julia Goodfellow Chief Executive, the Biotechnology and Biological Sciences Research Council Professor Colin Bird Sir Douglas Black Formerly Dean of Medicine and Provost of Faculty Group of Medical and Veterinary Medicine, University of Edinburgh Sir Douglas Black: died September 13, 2002. It is with Medical School much sadness that we record the passing of a distinguished Honorary Fellow. The Black report was widely Professor Jonathan Cohen regarded as the most authoritative publication on the link Dean, Brighton & Sussex Medical School between poor health and social deprivation. That it became Professor Thomas Kirkwood so influential was at least in part due to the then Professor of Medicine, University of Newcastle Upon Tyne Government’s efforts to suppress its publication. Council is pleased to announce the appointment of Sir John Skehel, Sir Douglas was a widely respected and much loved FRS FMedSci, as Shadow Vice-President with responsibility for Professor of Medicine at Manchester and later President of non-clinical affairs. -
Life Changing Science
LIFE CHANGING SCIENCE The Francis Crick Institute Annual Review 2017/18 AN INSTITUTE FOR DISCOVERY Our commitment to excellence, our emphasis on multidisciplinary research, our focus on young and emerging talent and our novel ways of partnership working are some of the factors that set the Crick apart. Front cover Vaccinia virus infection (green) disrupts a layer of epithelial cells (red/blue). Courtesy of Michael Way, Group Leader at the Crick. INTRODUCTION 2 Who we are Our year at a glance 2 Introduction by Paul Nurse 4 The Francis Crick Institute is a biomedical Progress against our strategy 6 discovery institute dedicated to understanding the RESEARCH HIGHLIGHTS 10 Cancer-causing mutation fundamental biology underlying health and disease. suppresses immune system 11 Our work is helping to build an understanding of Predicting lung cancer’s return 12 New understanding of human why disease develops and to translate discoveries embryo development 14 Chemical attraction could improve into new ways to prevent, diagnose and treat cancer immunotherapy 16 illnesses such as cancer, heart disease, stroke, Genes linked to malaria parasites’ persistence 17 infections and neurodegenerative diseases. Architecture of our ‘second brain’ 18 Cause of infertility side-stepped in mice 19 Mechanism for spinal cord development discovered 20 A new layer of complexity in embryo development 21 Two DNAs wedded with this ring 22 Unravelling how DNA gets copied 23 Telomerase’s dark side discovered 24 REVIEW OF THE YEAR 26 New group leaders arrive 27 Joined-up thinking 30 Focusing on the molecules of life 32 CryoEM at the Crick 34 Bringing academia and industry closer together 36 The people making research happen 38 Patterns in art and science 40 Rewarding research 42 Appointments 43 Supporting new discoveries 44 Our vision What’s inside Our vision is to be a world- We bring together outstanding scientists Science feature 32 leading multidisciplinary from all disciplines and carry out research Sophisticated microscopy is being biomedical research institute. -
ITMAT 11 Annual International Symposium Monday and Tuesday, October 17-18, 2016 Perelman School of Medicine, University of Penns
ITMAT 11th Annual International Symposium Monday and Tuesday, October 17-18, 2016 Perelman School of Medicine, University of Pennsylvania Smilow Center for Translational Research (SCTR) The Arthur Rubenstein Auditorium 3400 Civic Center Boulevard, Philadelphia, PA Translational Science in the Era of Precision Medicine Monday, October 17 (Day 1) 8:00 AM Registration and Breakfast: Smilow Lobby 8:45 Introduction J. Larry Jameson, MD, PhD, Executive Vice President, University of Pennsylvania for the Health System, and Dean, Perelman School of Medicine, University of Pennsylvania Session 1: Precision Medicine Initiatives at Scale Session Chairs: Sir Keith Peters, FRCP, FRS, FMedSci, Emeritus Regius Professor of Physic, University of Cambridge, Consultant in Clinical Science and Translational Medicine to the Francis Crick Institute and Senior Consultant in R&D to GlaxoSmithKline and Jonathan A. Epstein, MD, Executive Vice Dean and Chief Scientific Officer, Perelman School of Medicine, University of Pennsylvania 9:00 Genes, Genomes and the Future of Medicine Richard Lifton, MD, PhD, President, Rockefeller University 9:30 Precision Medicine and Global Health Ezekiel J. Emanuel, MD, PhD, Vice Provost for Global Initiatives, Chair, Department of Medical Ethics and Health Policy, University of Pennsylvania 10:00 Precision Medicine in the UK: from 100,000 Whole Genomes to 65 Million Patients Professor Sir John Savill, MB ChB, PhD, FRS, Chief Executive, Medical Research Council UK 10:30 COFFEE: Smilow Lobby Session 2: The Biology of Senescence Session Chairs: Virginia M.-Y. Lee, PhD, Professor of Pathology and Laboratory Medicine, Director, The Center for Neurodegenerative Disease Research at the Perelman School of Medicine of the University of Pennsylvania and Nancy M. -
Institute of Contemporary British History
Origins of the National Institute for Health Research Edited by Paul Atkinson and Sally Sheard Department of Public Health and Policy University of Liverpool © Department of Public Health and Policy, University of Liverpool. All rights reserved. This material is made available for personal research and study only. We give permission for this file to be downloaded for such personal use. For reproduction or further distribution of all or part of this file, permission must be sought from the copyright holder. Published by: Department of Public Health and Policy, University of Liverpool, 2018. ISBN: 978-1-9999209-3-7 Origins of the National Institute for Health Research Transcript of a Witness Seminar held at the University of Liverpool in London on 28 February 2018 Acknowledgements: The convenors would like to thank the witnesses for their contributions, and the staff at the University of Liverpool in London and Ubiqus for their support. Photographs: Department of Public Health and Policy, University of Liverpool. Contents Introduction…………………………………………………………………………………………p1 Contributors……………..………………………………………………………………………….p4 Areas for Discussion……...………………………………………………………………………...p6 Witness Seminar Transcript…………………………………………………………………….…..p8 Instructions for Citation This document has also been published online. References to this Witness Seminar should refer readers to the online version, following the format below: [Witness name], in The Origins of the National Institute for Health Research, held 28 February 2018 at the University of Liverpool in London, published by the Department of Public Health and Policy, University of Liverpool, 2018, https://www.liverpool.ac.uk/psychology-health-and- society/research/ governance-of-health/witness-seminars/ [page number of reference]. Introduction There has been publicly-funded health research in the UK for just over 100 years, but the idea that the National Health Service needs to commission some of it is only a generation old. -
Management and Planning Group
Imperial College London - Faculty of Medicine Fellowships Criteria for the award of Fellowships The following criteria mirror the College’s criteria for the election of Fellows. 1. Fellowships of the Imperial College Faculty of Medicine may be awarded: to former members of staff or to former students of Imperial College Faculty of Medicine, who may be deemed eligible by reason of their outstanding achievements or of exceptional services rendered to the Faculty; to other persons not members of the Faculty who are of outstanding distinction in appropriate fields and whom the Faculty wishes to honour. 2. In the above criteria “achievement” should mean truly outstanding and “services” to the Faculty truly exceptional; former staff (who are not former students) should be selected mainly from those who have retired as Professors of eminence in their fields and especially those who have rendered special service to the Faculty as Deans, Heads of Divisions, etc. 3. A person who on his/her retirement was a member of the staff of the Faculty should not be considered for election to Fellowship until one calendar year has elapsed since his/her retirement or since his/her appointment as Senior Research Fellow. Fellows At the 1999 Fellowship Ceremony, [awarded June 1999], the fellows of the former RPMS were converted to Fellows of ICSM. Sir Christopher Booth, M Wohl, Esq Emeritus Professor Sir John Dacie, The Lord Wolfson, Selywn F Taylor, Esq, Mrs Kay Glendinning S M Mellinkoff Esq, Professor EGL Bywaters, Sir Godfrey Hounsfield, Professor DG Melrose, -
Human Radiation Studies: Remembering the Early Years
DOElEH -0458 727849 HUMAN RADIATION STUDIES: REMEMBERING THE EARLY YEARS Oral History of Dr. Patricia Wallace Durbin, Ph. D. Conducted November 11, 1994 United States Department of Energy Office of Human Radiation Experiments FOREWORD N DECEMBER1993, U.S. Secretary of Energy Hazel R. O’Leary announced her Openness Initiative. As part of this initiative, the Department of Energy Iundertook an effort to identify and catalog historical documents on radiation experiments that had used human subjects. The Office of Human Radiation Ex- periments coordinated the Department’s search for records about these experi- ments. An enormous volume of historical records has been located. Many of these records were disorganized; often poorly cataloged, if at all; and scattered across the country in holding areas, archives, and records centers. The Department has produced a roadmap to the large universe of pertinent infor- mation: Human Radiation Experiments: The Department of Energy Roadmap to the Story and the Records (DOEEH-0445, February 1995). The collected docu- ments are also accessible through the Internet World Wide Web under http : / /www. ohre .doe .gov . The passage of time, the state of existing re- cords, and the fact that some decisionmaking processes were never documented in written form, caused the Department to consider other means to supplement the documentary record. In September 1994, the Office of Human Radiation Experiments, in collaboration with Lawrence Berkeley Laboratory, began an oral history project to fulfill this god. The project involved interviewing researchers and others with firsthand knowledge of either the human radiation experimentation that occurred during the Cold War or the institutional context in which such experimentation took place. -
Annual Review 2009 2 Contents
Annual Review 2009 2 Contents Who’s Who Schools of Contents the University Honorary Officers Full information and contact Vice-Chancellor’s preface 4 President details of our academic The year in pictures 6 Professor Sir Martin Evans FRS Schools can be found at For our students 8 the University website For the advancement of knowledge 10 Vice-Presidents Ms Menna Richards OBE www.cardiff.ac.uk For our communities 12 Mr WH John MBE People and organisation 16 Lady Jones Parry Welsh School of Architecture Partnership and community 18 Mr Huw Edwards Cardiff School of Biosciences Estates and information infrastructure 20 Chair of Council Cardiff Business School Investment 24 Professor Sir Keith Peters FRS Cardiff School of Chemistry Communication 28 PMedSci New faces 30 Cardiff School of City and Vice Chair of Council Regional Planning Appointments and distinctions 32 Mr Dick Roberts OBE University in numbers 34 Cardiff School of Computer Treasurer Science and Informatics Strategy Map 36 Mr Hywel Jones CBE Financial performance 37 School of Dentistry Visitor Grants, gifts and donations 38 Cardiff School of Earth Rt Hon Sir Anthony Evans QC and Ocean Sciences Honorary International Cardiff School of Engineering Vice-President Professor Zhong Binglin Cardiff School of English, Communication and Philosophy Vice-Chancellor Cardiff School of European Studies Vice-Chancellor Dr David Grant CBE School of Healthcare Studies Deputy Vice-Chancellor Cardiff School of History Professor Peter Blood and Archaeology Cardiff School of Journalism, Pro Vice-Chancellors -
Clinical Pharmacology in the UK, C. 1950–2000: Influences and Institutions
CLINICAL PHARMACOLOGY IN THE UK, c. 1950–2000: INFLUENCES AND INSTITUTIONS The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 6 February 2007 Edited by L A Reynolds and E M Tansey Volume 33 2008 ©The Trustee of the Wellcome Trust, London, 2008 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 117 2 All volumes are freely available online following the links to Publications/Wellcome Witnesses at www.ucl.ac.uk/histmed Technology Transfer in Britain: The case of monoclonal antibodies; Self and Non-Self: A history of autoimmunity; Endogenous Opiates; The Committee on Safety of Drugs • Making the Human Body Transparent: The impact of NMR and MRI; Research in General Practice; Drugs in Psychiatric Practice; The MRC Common Cold Unit • Early Heart Transplant Surgery in the UK • Haemophilia: Recent history of clinical management • Looking at the Unborn: Historical aspects of obstetric ultrasound • Post Penicillin Antibiotics: From acceptance to resistance? • Clinical Research in Britain, 1950–1980 • Intestinal Absorption • Origins of Neonatal Intensive Care in the UK • British Contributions to Medical Research and Education in Africa after the Second World War • Childhood Asthma and Beyond • Maternal Care • Population-based Research in South Wales: The MRC Pneumoconiosis Research Unit and the MRC -
Radiation Safety Review Course Syllabus
Radiation Safety Review Course Outline Module I: Content Pertaining to a RAM Licenses Nuclear Medicine and PET Terminology…………………....... Lecture 1 120 min Basic Math Skills for Nuclear Medicine Technologists I…….. Lecture 2 60 min Basic Math Skills for Nuclear Medicine Technologists II……. Lecture 3 60 min Introduction to Dose Calibrators………………………………. Lecture 4 60 min Introduction to Survey Meters…………………………………. Lecture 5 60 min Introduction to ScintillatorDetectors………………………....... Lecture 6 60 min The Electronics of Scintigraphy………………………………… Lecture 7 60 min Radiation Detection and Measurements…………………....... Lecture 8 90 min Gaseous Detectors Used in the PET Lab…………………….. Lecture 9 60 min Alpha & Beta Decay…………………………………………….. Lecture 10 60 min Atomic Structure and Nuclear Stability………………………… Lecture 11.1 60 min Atomic and Nuclear Structure………………………………….. Lecture 11.2 60 min Background Radiation…………………………………………… Lecture 12 45 min Gamma Decay, Positron Decay, and Electron Capture……... Lecture 13 60 min Radionuclide Production………………………………………… Lecture 14 90 min Production of Radionuclides……………………………………. Lecture 15 60 min PET Radiopharmaceuticals…………………………………….. Lecture 16 60 min PET Quality Control……………………………………………… Lecture 17 60 min The Nuclear Pharmacy………………………………………….. Lecture 18 60 min Radioactive Receipt……………………………………………... Lecture 19 60 min Radioactive Waste Disposal……………………………………. Lecture 20 60 min Radiation Physics & Instruments………………………………. Lecture 21 90 min Radiation Dosimetry and Units…………………………………. Lecture