AFC TNFa/ Published Title QUALIFIER NAME DMSO , alpha-induced 6 206026_s_at TNFAIP6 20.96 sphingosine-1-phosphate phosphotase 2 226560_at SGPP2 17.29 BCL2-related protein A1 205681_at BCL2A1 10.79 pentaxin-related , rapidly induced by IL-1 beta 206157_at PTX3 10.08 tumor necrosis factor, alpha-induced protein 2 202510_s_at TNFAIP2 8.39 oxidised low density lipoprotein (lectin-like) receptor 1 210004_at OLR1 7.81 chemokine (C-C motif) ligand 20 205476_at CCL20 7.76 interleukin 8 202859_x_at IL8 6.12 TNF receptor-associated factor 1 205599_at TRAF1 6.05 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor 202638_s_at ICAM1 5.70 interleukin 1 family, member 9 220322_at IL1F9 5.19 baculoviral IAP repeat-containing 3 210538_s_at BIRC3 5.10 chemokine (C-X-C motif) ligand 10 204533_at CXCL10 5.07 NFkB inhibitor, alpha 201502_s_at NFKBIA 4.97 tumor necrosis factor, alpha-induced protein 3 202643_s_at TNFAIP3 4.74 ninjurin 1 203045_at NINJ1 4.57 sister-of-mammalian grainyhead 232116_at TFCP2L4 4.37 matrix metalloproteinase 13 (collagenase 3) 205959_at MMP13 4.29 solute carrier family 7, member 2 225516_at SLC7A2 4.00 tumor necrosis factor receptor superfamily, member 9 211786_at TNFRSF9 3.77 CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) 204440_at CD83 3.67 small proline-rich protein 2B 208539_x_at SPRR2B 3.50 interleukin 4 induced 1 230966_at IL4I1 3.23 plasminogen activator, urokinase 205479_s_at PLAU 3.17 8 open reading frame 4 218541_s_at C8ORF4 3.16 putative lymphocyte G0/G1 switch gene 213524_s_at G0S2 3.07 laminin, alpha 2 (merosin, congenital muscular dystrophy) 213519_s_at LAMA2 3.04 CDNA FLJ11041 fis, clone PLACE1004405. 227140_at INHBA 3.00 B-cell CLL/lymphoma 3 204908_s_at BCL3 2.98 superoxide dismutase 2, mitochondrial 1566342_at SOD2 2.89 hypothetical protein FLJ25078 229933_at FLJ25078 2.84 chemokine (C-X-C motif) ligand 1 204470_at CXCL1 2.80 chemokine (C-X-C motif) ligand 2 209774_x_at CXCL2 2.79 RAB3A interacting protein (rabin3) 223471_at RAB3IP 2.75 interleukin 1 receptor antagonist 216243_s_at IL1RN 2.73 NFkB 2 (p49/p100) 209636_at NFKB2 2.71 polyamine oxidase (exo-N4-amino) 50400_at PAOX 2.70 NFkB inhibitor, epsilon 203927_at NFKBIE 2.67 keratin 6B 213680_at KRT6B 2.64 KIAA1718 protein 225142_at KIAA1718 2.63 Homo sapiens small proline-rich protein 2C (pseudogene) 220664_at SPRR2C 2.63 interleukin 29 (interferon, lambda 1) 1552917_at IL29 2.63 interleukin-1 receptor-associated kinase 2 231779_at IRAK2 2.56 dual adaptor of phosphotyrosine and 3-phosphoinositides 222859_s_at DAPP1 2.56 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 202284_s_at CDKN1A 2.55 TNFAIP3 interacting protein 1 207196_s_at TNIP1 2.55 ubiquitin specific protease 18 219211_at USP18 2.55 occludin 209925_at OCLN 2.45 interleukin 1 receptor, type II 205403_at IL1R2 2.43 GTP cyclohydrolase 1 (dopa-responsive dystonia) 204224_s_at GCH1 2.43 neuron navigator 3 204823_at NAV3 2.42 protease inhibitor 3, skin-derived (SKALP) 203691_at PI3 2.40 hypothetical protein LOC134285 1553559_at LOC134285 2.39 Homo sapiens chromosome 5 clone RP11-215G15 231963_at UNK_BG11193 2.39 interleukin 23, alpha subunit p19 220054_at IL23A 2.37 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 202625_at LYN 2.34 hypothetical protein LOC54103 213142_x_at tcag7.1314 2.34 interleukin 7 receptor 226218_at IL7R 2.34 solute carrier organic anion transporter family, member 3A1 219229_at SLCO3A1 2.31 putative chemokine receptor 205220_at GPR109B 2.30 ankyrin repeat and BTB (POZ) domain containing 2 213497_at ABTB2 2.29 proline-rich nuclear receptor coactivator 1 209034_at PNRC1 2.29 TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator 231932_at T3JAM 2.29 solute carrier family 2 (facilitated glucose transporter), member 6 220091_at SLC2A6 2.28 KIAA0303 protein 225611_at KIAA0303 2.28 chemokine (C-X-C motif) ligand 3 207850_at CXCL3 2.27 DnaJ (Hsp40) homolog, subfamily B, member 6 209015_s_at DNAJB6 2.26 tubulin, beta polypeptide 204141_at TUBB 2.25 tripartite motif-containing 15 210177_at TRIM15 2.21 claudin 18 214135_at CLDN18 2.20 chemokine (C-X-C motif) ligand 11 210163_at CXCL11 2.19 transmembrane and coiled-coil domain family 3 (KIAA1145) 226489_at TMCC3 2.19 G protein-coupled receptor 132 223887_at GPR132 2.18 promyelocytic leukemia 209640_at PML 2.16 hypothetical protein FLJ23563 227180_at ELOVL7 2.16 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 204872_at TLE4 2.10 leukemia inhibitory factor (cholinergic differentiation factor) 205266_at LIF 2.10 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 242961_x_at DDX58 2.09 Rab coupling protein 225177_at RCP 2.08 hypothetical protein MGC19764 1557078_at MGC19764 2.07 diphtheria toxin receptor 38037_at DTR 2.07 syndecan 4 (amphiglycan, ryudocan) 202071_at SDC4 2.06 START domain containing 5 213820_s_at STARD5 2.06 bone morphogenetic protein 2 205289_at BMP2 2.06 cyclin G2 202769_at CCNG2 2.06 pellino homolog 1 (Drosophila) 218319_at PELI1 2.06 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 1555355_a_at ETS1 2.05 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 222793_at DDX58 2.04 v-rel reticuloendotheliosis viral oncogene homolog B 205205_at RELB 2.03 small proline-rich protein 1A 213796_at SPRR1A 2.03 matrix metalloproteinase 10 (stromelysin 2) 205680_at MMP10 2.03 hypothetical protein FLJ90005 36564_at IBRDC3 2.03 serine (or Cys) proteinase inhibitor, clade B (ovalbumin), member 1 228726_at SERPINB1 2.03 semaphorin 4C 46665_at SEMA4C 2.02 tumor necrosis factor, alpha-induced protein 8 210260_s_at TNFAIP8 2.00 nuclear receptor coactivator 7 225344_at NCOA7 1.99 hypothetical protein LOC54103 222150_s_at LOC54103 1.98 suppressor of cytokine signaling 3 227697_at SOCS3 1.97 GPI-anchored metastasis-associated protein homolog 204952_at C4.4A 1.96 hypothetical protein FLJ38725 228937_at FLJ38725 1.95 CCAAT/enhancer binding protein (C/EBP), beta 212501_at CEBPB 1.93 1 222802_at EDN1 1.93 chemokine (C-C motif) ligand 5 204655_at CCL5 1.90 neural precursor cell expressed, developmentally down-regulated 4-like 212445_s_at NEDD4L 1.90 phosphoprotein associated with glycosphingolipid-enriched microdomains 227354_at PAG 1.87 EH-domain containing 1 209037_s_at EHD1 1.86 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 209723_at SERPINB9 1.86 dual specificity phosphatase 16 224832_at DUSP16 1.86 -activating factor receptor 206278_at PTAFR 1.86 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 36711_at MAFF 1.86 Nedd4 binding protein 1 204601_at N4BP1 1.85 ephrin-A1 202023_at EFNA1 1.84 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 225612_s_at B3GNT5 1.84 Nedd4 binding protein 1 32069_at N4BP1 1.84 HCV NS3-transactivated protein 2 218706_s_at NS3TP2 1.83 zinc finger protein 165 206683_at ZNF165 1.83 9 205659_at HDAC9 1.83 ring finger protein 19B 213038_at RNF19B 1.82 homocysteine-inducible, ER stress-inducible, ubiquitin-like domain member 1 217168_s_at HERPUD1 1.82 interleukin 1, alpha 210118_s_at IL1A 1.81 peroxisomal proliferator-activated receptor A interacting complex 285 228230_at PRIC285 1.80 chromosome 20 open reading frame 54 228236_at C20ORF54 1.80 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) 209239_at NFKB1 1.79 laminin, beta 3 209270_at LAMB3 1.79 Homo sapiens chromosome 10 224606_at UNK_BG25072 1.79 melanoma differentiation associated protein-5 219209_at IFIH1 1.78 kynureninase (L-kynurenine ) 204385_at KYNU 1.78 protease inhibitor 3, skin-derived (SKALP) 41469_at PI3 1.78 purinergic receptor P2Y, G-protein coupled, 5 218589_at P2RY5 1.78 Homo sapiens cDNA FLJ13604 230047_at FLJ13604 1.77 chemokine (C-X-C motif) ligand 16 223454_at CXCL16 1.76 CDNA FLJ42435 fis, clone BLADE2006849 227755_at FLJ42435 1.76 TNFAIP3 interacting protein 2 48531_at TNIP2 1.76 NFkB inhibitor, zeta 223218_s_at NFKBIZ 1.76 TNF receptor superfamily, member 10d, decoy with truncated death domain 227345_at TNFRSF10D 1.75 rhotekin 225150_s_at RTKN 1.74 protein kinase STYK1 220030_at STYK1 1.74 ATP-binding cassette, sub-family A (ABC1), member 12 215465_at ABCA12 1.74 DKFZP586N0721 protein 218284_at DKFZP586N07 1.74 claudin 1 222549_at CLDN1 1.73 transmembrane 4 superfamily member 1 209386_at TM4SF1 1.73 small proline-rich protein 3 218990_s_at SPRR3 1.72 interferon-induced protein with tetratricopeptide repeats 1 203153_at IFIT1 1.72 ankyrin repeat domain 22 238439_at ANKRD22 1.72 v-ets erythroblastosis virus E26 oncogene homolog 1 224833_at ETS1 1.72 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 228625_at CITED4 1.71 interferon-induced protein with tetratricopeptide repeats 4 229450_at IFIT4 1.71 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 221485_at B4GALT5 1.70 interferon gamma receptor 2 (interferon gamma transducer 1) 201642_at IFNGR2 1.70 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 235020_at TAF4B 1.70 natural killer cell transcript 4 203828_s_at NK4 1.70 SPRY domain-containing SOCS box protein SSB-1 226075_at SSB1 1.70 RNA binding motif protein 16 227866_at RBM16 1.70 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 202307_s_at TAP1 1.70 nuclear factor of activated T-cells 5, tonicity-responsive 224984_at NFAT5 1.69 hypothetical protein FLJ23186 219474_at FLJ23186 1.69 AD031 protein 223595_at AD031 1.69 semaphorin 7A, GPI membrane anchor 230345_at SEMA7A 1.69 hypothetical protein LOC129607 226702_at LOC129607 1.69 likely ortholog of rat SNF1/AMP-activated protein kinase 220987_s_at SNARK 1.69 RAB24, member RAS oncogene family 225251_at RAB24 1.68 sterile alpha motif domain containing 4 212845_at SAMD4 1.67 nephroblastoma overexpressed gene 214321_at NOV 1.67 regulatory factor X, 5 (influences HLA class II expression) 202963_at RFX5 1.67 IGF-like family member 1 239430_at IGFL1 1.67 NS5ATP13TP2 protein 225510_at NS5ATP13TP2 1.66 tumor necrosis factor (ligand) superfamily, member 10 202687_s_at TNFSF10 1.66 Homo sapiens integrin, beta 8 226189_at ITGB8 1.65 hypothetical protein MGC45731 227080_at MGC45731 1.65 normal mucosa of esophagus specific 1 223484_at NMES1 1.65 bromodomain adjacent to zinc finger domain, 1A 217986_s_at BAZ1A 1.64 hypothetical protein FLJ23231 218810_at FLJ23231 1.64 DnaJ (Hsp40) homolog, subfamily C, member 3 208499_s_at DNAJC3 1.64 activating transcription factor 3 202672_s_at ATF3 1.64 GRP1-binding protein GRSP1 213056_at GRSP1 1.64 Snf2-related CBP activator protein 38766_at SRCAP 1.64 serum/glucocorticoid regulated kinase 201739_at SGK 1.63 DNA-damage-inducible transcript 4 202887_s_at DDIT4 1.63 plasminogen activator, urokinase receptor 214866_at PLAUR 1.63 Homo sapiens chromosome 17, clone RP11-697E22 213637_at UNK_BE50339 1.63 ras homolog gene family, member F (in filopodia) 219045_at RHOF 1.62 peroxisome proliferative activated receptor, delta 37152_at PPARD 1.62 interleukin 1, beta 205067_at IL1B 1.61 Down syndrome critical region gene 1 208370_s_at DSCR1 1.61 NEDD8 ultimate buster-1 222512_at NYREN18 1.61 B-cell translocation gene 1, anti-proliferative 200921_s_at BTG1 1.60 angiomotin like 2 203002_at AMOTL2 1.60 interferon stimulated gene 20kDa 33304_at ISG20 1.60 CDC42 effector protein (Rho GTPase binding) 4 218062_x_at CDC42EP4 1.60 interferon-stimulated transcription factor 3, gamma 48kDa 203882_at ISGF3G 1.59 KIAA1404 protein 225076_s_at KIAA1404 1.59 presenilin 1 (Alzheimer disease 3) 203460_s_at PSEN1 1.59 sequestosome 1 201471_s_at SQSTM1 1.59 203159_at GLS 1.58 Consensus includes gb:AA876179 238755_at UNK_AA87617 1.58 dedicator of cytokinesis 4 205003_at DOCK4 1.58 BTG family, member 2 201236_s_at BTG2 1.58 malignant fibrous histiocytoma amplified sequence 1 225478_at MFHAS1 1.58 hypothetical protein FLJ22595 220468_at FLJ22595 1.57 receptor-interacting serine-threonine kinase 2 209545_s_at RIPK2 1.57 Consensus includes gb:AI949912 240013_at UNK_AI949912 1.57 MAD, mothers against decapentaplegic homolog 3 (Drosophila) 205398_s_at SMAD3 1.57 squamous cell carcinoma antigen recognized by T cells 2 218854_at SART2 1.57 NCK adaptor protein 1 204725_s_at NCK1 1.56 hypothetical protein FLJ21069 226425_at FLJ21069 1.56 TRAF family member-associated NFKB activator 209451_at TANK 1.56 ceroid-lipofuscinosis, neuronal 5 204085_s_at CLN5 1.56 hypothetical protein MGC13251 224469_s_at C14ORF151 1.56 Consensus includes gb: AK024927 232202_at FLJ21274 1.56 ankyrin repeat domain 12 212286_at ANKRD12 1.56 interleukin 15 205992_s_at IL15 1.56 hypothetical protein FLJ11259 218627_at FLJ11259 1.55 interferon regulatory factor 1 202531_at IRF1 1.55 Human DNA sequence from clone RP3-493F7 on chromosome 6q22.1-22.33 240214_at UNK_BF05920 1.55 BH3 interacting domain death agonist 204493_at BID 1.55 MARCKS-like protein 200644_at MLP 1.54 interferon regulatory factor 6 202597_at IRF6 1.54 B cell RAG associated protein 203066_at GALNAC4S-6S 1.53 mitogen-activated protein kinase kinase 3 207667_s_at MAP2K3 1.53 MAX dimerization protein 1 228846_at MAD 1.53 KIAA1726 protein 231899_at KIAA1726 1.53 human immunodeficiency virus type I enhancer binding protein 1 204512_at HIVEP1 1.53 tumor necrosis factor receptor superfamily, member 10b 209295_at TNFRSF10B 1.53 2'-5'-oligoadenylate synthetase-like 205660_at OASL 1.52 F-box and leucine-rich repeat protein 11 208989_s_at FBXL11 1.52 interferon gamma receptor 1 211676_s_at IFNGR1 1.52 toll-like receptor 2 204924_at TLR2 1.52 guanylate binding protein 3 223434_at GBP3 1.51 sorting nexin 9 223027_at SNX9 1.51 baculoviral IAP repeat-containing 2 202076_at BIRC2 1.51 butyrophilin, subfamily 2, member A1 211256_x_at BTN2A1 1.51 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) 202880_s_at PSCD1 1.51 glutamate-cysteine , catalytic subunit 202923_s_at GCLC 1.50 open reading frame 22 221260_s_at C12ORF22 1.50 DKFZP434H132 protein 204495_s_at DKFZP434H13 1.50 tripartite motif-containing 38 203610_s_at TRIM38 1.50

Supplemental Table S2: Unique induced by TNFalpha and response to IKI-1. For each cohort, RNA was individually purified from three independently treated cell samples, amplified and hybridized to three independent oligonucleotide arrays. Signal intensity was averaged for each of the treatment groups and reported in columns I to L along with standard of deviation (columns M-P). Average Fold Change and Student tTest (not corrected for false discovery rate) comparing TNFalpha to Vehicle treatments is presented in column D and E. Average Fold Change and Student tTest comparing TNFalpha and IKI-1 cotreatment relative to TNFalpha alone is presented in column F and G. Column H reports percentage of TNFalpha induced mRNA reversed by cotreatment with IKI-1. Genes were selected by minimum average fold change greater than 1.5 (P<0.01) with minimum mean signal intensity >50 following TNFalpha induction. ttest AFC TNFa ttest TNFa Mean Mean StDev StDev StDev IKI StDev TNFa/ + IKI-1/ + IKI-1/ % Inhibition Mean TNFa 5ng Mean IKI-1 TNFa + IKI- DMSO TNFa 1 1uM TNFa + DMSO TNFa TNFa by IKI-1 DMSO 3hr 3hr 1uM 3hr 1 3hr 3hr 5ng 3hr 3hr IKI-1 3hr 0.0038 -11.69 0.0065 96.0 8 165 6 14 7227 3 0.0041 -2.72 0.0074 67.1 8 133 11 49 4174 6 0.0000 -3.08 0.0001 74.4 26 282 21 91 11 14 11 16 0.0023 -2.68 0.0030 69.5 56 561 69 210 8478 16 0.0001 -3.85 0.0004 84.0 147 1232 154 320 23 55 23 19 0.0000 -4.19 0.0012 87.3 79 615 76 147 23 30 23 4 0.0034 -1.97 0.0056 56.5 43 334 41 170 1301 11 0.0019 -1.52 0.0066 41.0 194 1191 375 782 27 99 27 94 0.0000 -1.46 0.0281 37.5 32 191 22 131 9109 22 0.0000 -2.33 0.0002 69.3 130 740 129 317 13 25 13 12 0.0015 -1.27 0.0333 26.4 25 132 28 103 4114 11 0.0002 -1.75 0.0013 53.5 36 181 15 103 9129 10 0.0022 -1.84 0.0196 56.9 333 1688 330 917 113 214 113 54 0.0001 -1.30 0.0128 29.0 229 1140 176 876 48 69 48 80 0.0000 -1.31 0.0003 30.2 236 1117 299 852 36 30 36 27 0.0002 -1.71 0.0011 53.0 40 184 34 108 13 12 13 11 0.0040 -1.05 0.6306 6.0 28 124 21 119 6166 11 0.0030 -3.28 0.0019 90.6 37 158 33 48 1121 4 0.0039 -5.22 0.0063 107.8 105 419 76 80 30 59 30 18 0.0143 -1.57 0.0748 49.7 16 62 17 39 5125 4 0.0053 -1.64 0.0134 53.5 61 223 59 136 7257 13 0.0134 -1.58 0.0335 51.2 310 1082 306 687 27 167 27 105 0.0058 1.01 0.9135 -1.7 16 51 23 51 84 8 7 0.0001 -1.20 0.0092 24.8 904 2867 1085 2379 88 131 88 121 0.0107 -3.18 0.0161 100.3 121 383 53 120 40 72 40 25 0.0000 1.30 0.0586 -44.2 287 879 449 1141 18 20 18 119 0.0046 -1.69 0.0309 61.0 30 90 36 53 9139 5 0.0008 -2.45 0.0003 88.7 471 1414 279 578 13 60 13 85 0.0010 -1.22 0.0114 27.4 79 235 74 192 4124 11 0.0008 -1.96 0.0287 75.0 97 281 100 143 14 4 14 42 0.0031 -2.35 0.0007 88.7 86 246 68 104 5195 18 0.0029 -1.69 0.0003 63.4 100 281 61 166 28 12 28 11 0.0002 1.18 0.0362 -27.7 72 201 86 237 73 713 0.0144 -1.79 0.0373 69.4 71 197 71 110 15 35 15 14 0.0029 -2.01 0.0059 79.3 562 1532 525 763 63 147 63 57 0.0017 -1.33 0.0308 39.6 39 105 37 79 6106 10 0.0027 -1.88 0.0108 74.2 31 83 34 44 10 8 10 2 0.0002 -1.35 0.0047 41.6 81 215 63 159 11 12 11 8 0.0006 -1.88 0.0017 75.1 66 176 78 94 12 14 12 11 0.0005 1.31 0.0295 -49.5 40 104 75 136 86 812 0.0117 -1.34 0.0776 41.3 61 161 48 120 6226 5 0.0148 -1.44 0.0837 49.2 20 52 16 36 83 8 9 0.0027 -1.40 0.0071 46.6 200 512 139 366 11 37 11 27 0.0003 -1.65 0.0028 64.7 291 744 252 451 40 50 40 26 0.0003 -1.11 0.1186 15.9 555 1417 574 1280 61 88 61 81 0.0000 -1.44 0.0062 50.4 464 1185 471 822 18 20 18 64 0.0003 -2.18 0.0070 89.2 27 70 25 32 44 4 8 0.0018 -1.63 0.0463 65.5 62 153 47 94 9159 28 0.0061 -1.44 0.0070 52.1 53 128 57 89 16 7 16 2 0.0002 -2.02 0.0001 85.7 399 969 332 481 14 33 14 24 0.0015 -1.48 0.0103 55.2 39 94 33 63 99 9 7 0.0002 -1.53 0.0144 59.3 149 358 181 234 17 19 17 37 0.0143 -2.02 0.0205 86.6 44 105 31 52 9189 9 0.0032 -1.86 0.0126 79.8 43 102 31 55 12 8 12 14 0.0008 -1.09 0.2322 14.0 62 148 63 136 11 11 11 9 0.0030 -1.56 0.0121 62.6 221 518 211 332 12 38 12 6 0.0003 -2.48 0.0004 104.2 76 178 52 72 11 11 11 12 0.0042 -1.58 0.0079 64.4 202 472 200 298 7347 11 0.0020 -1.45 0.0123 54.3 75 173 83 119 10 16 10 13 0.0002 -2.33 0.0000 101.0 269 619 154 265 6166 10 0.0032 -1.27 0.0526 37.9 83 190 75 149 11 20 11 16 0.0108 -2.01 0.0127 89.2 30 69 12 34 11 9 11 11 0.0012 -2.03 0.0071 90.3 41 94 31 46 52 5 8 0.0014 -1.30 0.0430 41.0 78 178 98 137 16 15 16 1 0.0000 -1.01 0.9391 1.3 133 304 138 302 10 11 10 42 0.0114 1.20 0.1653 -35.2 23 52 38 63 59 5 5 0.0034 -2.37 0.0059 103.8 345 779 257 328 40 78 40 24 0.0019 -1.65 0.0065 70.9 243 546 204 331 15 38 15 11 0.0121 -1.30 0.0004 42.5 31 69 42 53 82 8 2 0.0049 -1.35 0.0233 47.5 106 232 109 172 7217 20 0.0062 -1.25 0.0574 37.2 313 687 346 548 92 69 92 57 0.0091 -1.40 0.0129 52.4 49 107 37 77 13 5 13 9 0.0043 -1.43 0.2805 55.5 36 79 32 56 99 928 0.0115 -1.65 0.0354 73.2 44 95 41 58 5135 16 0.0010 -1.69 0.0010 76.3 147 316 161 187 22 13 22 19 0.0011 -2.13 0.0041 101.2 56 118 37 55 85 811 0.0009 1.18 0.3477 -34.6 116 244 109 288 18 18 18 63 0.0005 -1.76 0.0012 83.0 155 324 129 184 20 21 20 13 0.0001 -1.33 0.0008 48.0 310 644 281 484 14 22 14 21 0.0071 -1.65 0.0000 75.8 93 193 77 117 17 4 17 4 0.0006 1.31 0.0381 -59.4 600 1242 952 1623 7 34 7 143 0.0001 -1.43 0.0007 58.2 2369 4879 2360 3419 150 195 150 157 0.0032 -2.01 0.0017 98.0 93 191 59 95 7167 10 0.0087 -1.26 0.1062 39.6 158 324 143 258 25 43 25 31 0.0002 -1.10 0.2715 18.4 277 570 320 516 28 27 28 62 0.0018 -1.48 0.0048 63.5 146 300 144 202 27 21 27 21 0.0069 -1.41 0.0285 57.3 349 713 271 504 35 79 35 73 0.0017 -1.66 0.0018 77.6 133 271 138 164 7177 18 0.0037 -1.06 0.0950 10.3 95 193 79 183 15 5 15 6 0.0040 -1.42 0.0270 58.0 932 1896 978 1337 99 186 99 55 0.0008 -1.34 0.0186 50.0 82 167 75 124 10 12 10 14 0.0018 -1.25 0.2102 39.3 220 447 171 358 10 26 10 86 0.0082 -2.06 0.0023 101.3 148 301 99 146 7297 21 0.0023 -2.05 0.0093 101.5 131 264 83 129 14 23 14 2 0.0007 -3.85 0.0001 147.9 175 351 56 91 23 19 23 14 0.0077 1.08 0.0211 -16.0 1327 2642 1537 2852 240 62 240 74 0.0105 -2.96 0.0004 133.6 73 144 41 49 15 3 15 7 0.0006 1.23 0.0279 -46.7 67 132 71 162 58 512 0.0023 -1.50 0.0086 68.3 144 283 156 188 18 25 18 16 0.0065 -2.23 0.0000 113.0 110 214 44 96 17 4 17 3 0.0000 -1.14 0.0111 24.8 1070 2063 1243 1817 32 20 32 58 0.0033 -1.04 0.4469 8.3 150 290 166 278 28 19 28 13 0.0110 -1.41 0.0546 60.9 98 187 114 133 21 26 21 10 0.0015 -1.68 0.0038 85.8 354 670 318 398 38 52 38 28 0.0085 -1.79 0.0097 94.8 34 64 20 36 58 5 6 0.0005 -1.12 0.0644 23.3 168 314 172 280 15 18 15 14 0.0002 -1.32 0.0343 52.4 275 511 239 387 17 10 17 44 0.0072 -1.34 0.0613 54.5 47 87 45 65 7107 2 0.0026 -1.40 0.0256 61.7 36 66 33 47 25 2 7 0.0004 -1.25 0.0028 43.9 597 1108 559 884 38 16 38 35 0.0019 -1.60 0.0054 81.6 139 258 121 161 16 21 16 11 0.0032 -2.53 0.0035 132.3 156 287 96 113 25 26 25 9 0.0015 -1.14 0.0397 27.1 746 1370 701 1201 33 76 33 46 0.0051 -1.70 0.0100 90.8 252 463 195 271 37 14 37 42 0.0080 1.01 0.7291 -2.2 236 432 214 437 42 16 42 13 0.0107 -1.47 0.0280 70.6 52 96 30 65 10 3 10 10 0.0000 -1.20 0.0816 36.4 172 313 140 262 67 629 0.0044 -1.24 0.0423 43.6 237 431 191 346 20 38 20 30 0.0067 1.24 0.0414 -53.8 1130 2056 2103 2555 138 226 138 166 0.0072 1.19 0.0526 -41.6 1614 2919 2796 3461 224 52 224 237 0.0012 -1.29 0.1429 50.5 39 70 35 54 55 512 0.0130 -2.59 0.0028 137.9 99 178 46 69 24 18 24 9 0.0015 -1.36 0.0108 59.9 636 1138 627 837 24 58 24 8 0.0001 -1.01 0.9461 1.2 1086 1942 1174 1933 56 39 56 223 0.0037 -1.47 0.0065 72.7 291 521 257 354 17 39 17 21 0.0133 -1.62 0.0281 87.2 109 194 94 120 26 23 26 4 0.0140 -1.76 0.0094 98.1 337 600 347 342 23 68 23 37 0.0013 -1.41 0.0053 66.5 235 418 230 297 28 28 28 18 0.0036 -1.82 0.0046 103.5 62 110 35 60 37 311 0.0030 -1.99 0.0079 114.5 70 123 61 62 8118 2 0.0062 -1.12 0.2393 24.1 128 226 154 203 1141 24 0.0076 1.20 0.0384 -47.3 78 137 112 165 3113 12 0.0136 -1.32 0.0032 56.6 212 372 183 281 39 12 39 18 0.0127 -1.91 0.0016 110.4 287 504 161 264 61 29 61 12 0.0064 1.07 0.4586 -15.8 294 515 491 550 41 55 41 49 0.0038 -1.84 0.0016 107.2 73 127 51 69 11 7 11 3 0.0024 -1.43 0.0100 70.8 97 169 109 118 13 13 13 14 0.0124 -1.34 0.0586 59.9 44 77 42 57 7107 4 0.0089 -2.07 0.0067 121.6 497 864 233 417 21 74 21 17 0.0009 -1.63 0.0046 91.6 1185 2052 968 1258 124 104 124 19 0.0006 -1.79 0.0010 104.7 1856 3206 1332 1793 142 171 142 92 0.0060 -1.02 0.8294 3.8 203 349 289 344 22 35 22 22 0.0039 -1.43 0.0175 71.5 366 631 367 442 57 50 57 13 0.0067 -1.54 0.0073 83.4 323 556 252 361 57 35 57 9 0.0000 -1.43 0.0033 71.9 1236 2120 853 1484 26 17 26 76 0.0052 -2.01 0.0027 120.5 115 197 63 98 17 19 17 13 0.0022 -1.37 0.0097 65.2 677 1158 704 844 85 56 85 6 0.0001 -1.03 0.5765 6.0 788 1341 905 1308 2112 86 0.0002 -1.27 0.0044 51.2 925 1575 842 1242 7257 59 0.0048 -1.59 0.0142 89.6 75 127 58 80 4104 0 0.0134 -1.13 0.3132 27.0 286 487 321 433 19 52 19 62 0.0067 -1.02 0.7735 5.0 80 137 76 134 10 14 10 6 0.0097 -1.11 0.2350 24.4 30 50 37 45 65 6 2 0.0072 -1.31 0.0410 58.3 173 294 184 224 27 31 27 14 0.0016 -1.22 0.0205 44.0 270 457 192 375 19 29 19 19 0.0016 1.35 0.0012 -86.2 184 311 262 421 22 17 22 16 0.0034 -2.41 0.0007 143.5 72 122 43 51 59 5 7 0.0014 1.14 0.1338 -34.8 83 140 131 160 96 915 0.0013 -1.09 0.3654 21.2 104 175 104 160 11 8 11 22 0.0001 -1.44 0.0365 75.2 158 267 114 185 46 430 0.0132 1.15 0.0381 -36.5 35 58 46 67 74 7 3 0.0022 -1.86 0.0014 114.5 203 340 160 183 20 25 20 19 0.0015 -1.32 0.0088 61.0 92 153 95 116 9109 9 0.0116 -1.54 0.0175 88.0 164 274 152 178 23 33 23 21 0.0037 -1.50 0.0075 83.6 226 376 246 251 30 31 30 31 0.0055 -1.24 0.1072 49.4 203 337 180 271 25 10 25 42 0.0071 -1.79 0.0105 111.2 134 222 103 124 18 23 18 8 0.0008 -1.99 0.0006 126.6 484 799 286 401 43 30 43 47 0.0014 1.03 0.5917 -8.7 251 414 356 428 22 11 22 38 0.0020 -1.45 0.0021 78.6 1385 2282 1381 1578 59 127 59 111 0.0015 -1.43 0.0036 77.3 397 652 319 455 40 41 40 37 0.0007 -1.06 0.3630 13.5 108 177 80 167 89 812 0.0027 -1.19 0.0131 40.9 45 74 55 63 52 5 4 0.0129 -1.48 0.0392 82.5 65 107 74 73 80 812 0.0114 -1.77 0.0144 111.9 91 149 46 84 15 17 15 6 0.0028 -1.56 0.0182 92.1 269 440 173 283 26 34 26 54 0.0021 -2.03 0.0033 130.6 406 663 247 327 32 46 32 14 0.0003 1.96 0.0002 -247.3 299 489 958 958 18 21 18 36 0.0012 -1.27 0.0069 55.6 201 328 204 258 20 18 20 12 0.0040 -1.75 0.0072 110.6 105 171 69 98 13 14 13 5 0.0019 -1.19 0.0315 41.6 205 332 224 279 22 21 22 19 0.0002 -1.09 0.0496 20.6 248 400 239 369 14 9 14 15 0.0002 1.37 0.0071 -98.5 1911 3081 3476 4235 107 77 107 225 0.0016 1.08 0.1597 -20.1 238 383 335 412 23 24 23 8 0.0108 -1.41 0.0232 77.1 447 719 455 509 18 60 18 11 0.0055 -1.45 0.0052 82.4 698 1115 463 771 100 80 100 54 0.0116 -1.23 0.0527 50.7 302 483 339 391 17 44 17 36 0.0010 -1.12 0.1367 28.7 128 205 152 183 10 11 10 16 0.0034 -1.81 0.0039 119.7 215 343 136 190 24 26 24 11 0.0147 -1.17 0.0326 38.2 171 273 187 234 31 16 31 12 0.0036 -1.36 0.0028 71.8 312 497 302 365 33 16 33 25 0.0002 -1.32 0.0035 66.0 472 749 478 566 24 27 24 38 0.0016 1.12 0.0313 -33.2 930 1478 1201 1659 91 69 91 68 0.0027 -1.88 0.0024 127.1 216 342 164 181 20 25 20 12 0.0063 1.07 0.2158 -19.3 55 86 66 93 86 8 4 0.0034 -1.55 0.0011 96.9 123 194 103 125 14 10 14 10 0.0103 -1.83 0.0060 124.0 75 119 41 65 12 10 12 4 0.0004 -1.20 0.0062 45.9 200 316 179 263 12 13 12 11 0.0014 -3.37 0.0001 193.8 162 255 55 76 15 12 15 8 0.0058 -1.38 0.0103 75.8 257 403 262 292 35 31 35 18 0.0117 -1.28 0.1410 59.8 39 61 35 48 36 310 0.0008 -1.38 0.0052 76.2 344 538 260 390 27 25 27 8 0.0058 -1.27 0.0313 58.0 448 701 409 554 38 8 38 48 0.0005 -1.35 0.0127 72.1 341 534 314 395 24 20 24 40 0.0117 -1.45 0.0040 86.4 296 462 209 318 47 25 47 31 0.0022 -1.48 0.0026 89.6 137 214 117 145 14 12 14 13 0.0077 -1.26 0.0189 57.9 138 215 151 170 19 12 19 16 0.0117 -1.68 0.0022 113.0 103 161 85 96 17 11 17 6 0.0071 -1.46 0.0108 87.4 177 276 181 190 15 25 15 22 0.0094 1.03 0.5374 -9.3 56 87 79 90 97 9 2 0.0003 -1.90 0.0114 132.5 61 95 51 50 44 411 0.0113 -1.51 0.0139 94.3 84 130 78 86 9149 11 0.0032 -2.18 0.0024 152.0 227 353 122 162 24 24 24 9 0.0127 1.15 0.1678 -41.4 35 53 68 61 46 4 6 0.0011 -1.21 0.0311 49.4 206 318 220 263 15 17 15 23 0.0118 -1.52 0.0196 96.8 629 970 520 639 57 99 57 34 0.0039 -1.18 0.0365 44.5 989 1521 896 1284 56 103 56 68 0.0042 -1.09 0.1307 23.5 277 425 240 390 11 26 11 17 0.0099 -1.22 0.0580 51.5 285 437 325 359 29 5 29 35 0.0096 -1.00 0.9654 0.8 208 319 275 318 11 26 11 22 0.0148 -1.41 0.0243 84.4 66 101 41 71 6116 9 0.0021 -1.15 0.0497 38.3 84 129 61 112 88 8 3 0.0020 -1.17 0.0009 42.2 1105 1691 946 1444 72 28 72 36 0.0014 -1.22 0.0395 53.2 619 943 608 771 52 48 52 77 0.0074 -1.30 0.1573 67.3 112 171 124 131 11 4 11 31 0.0058 -1.37 0.0001 78.7 1032 1570 863 1147 96 33 96 25 0.0045 -1.88 0.0040 137.9 69 105 60 56 78 711 0.0068 -2.01 0.0089 148.8 776 1172 522 582 72 100 72 11 0.0104 -1.84 0.0047 134.8 147 222 104 121 16 4 16 15 0.0080 -1.48 0.0066 95.6 651 983 547 665 33 76 33 75 0.0135 1.01 0.9454 -3.1 39 58 48 59 65 613 0.0106 -1.34 0.1030 75.8 90 135 86 101 11 4 11 21 0.0031 -1.41 0.0070 86.8 547 822 380 583 48 56 48 29 0.0023 -1.45 0.0045 92.6 88 132 73 91 74 7 8 0.0044 -1.11 0.1274 28.5 155 233 179 211 17 11 17 16 0.0141 -1.54 0.0163 104.9 66 99 62 64 10 5 10 10