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Atropine-Like Psychosis."' 370, 371 Scopolamine, N-Ethyl-3-Piperidyl Benzilate (JB- 318) and LSD-25) 375

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Atropine-Like Psychosis. 92 H. ISBELL & T. L. CHRUSCIEL 366. Stockings, G. T. (1940) J. ment. Sci., 86, 29 (A 368. Unger, S. M. (1963) Psychiatry, 26, 111-125 clinical study of the mescaline psychosis with (Mescaline, LSD, psilocybin and personality special reference to the mechanism of the genesis change) of schizophrenia and other psychotic states) 369. Wolbach, A. B., Isbell, H. & Miner, E. J. (1962) 367. Thale, T., Gabrio, B. W. & Solomon, K. (1950) Psychopharmacologia (Ber.), 3, 1 (Cross- Amer. J. Psychiat., 106, 686-691 (Hallucinations tolerance between mescaline and LSD-25 with a and imagery by mescaline) comparison of the mescaline and LSD reactions) HALLUCINOGENIC ANTICHOLINERGICS As explained above, the subjective reaction to 373. Innes, I. R. & Nickerson, M. (1965) In: Goodman, these drugs (Table XVIII) is dysphoric and not L. S. & Gilman, A., ed., The pharmacological euphoric, and, although persons prone to drug basis of therapeutics, 3rd ed., pp. 521-545, dependence may try them once, they do not do so a Macmillan Co., New York (Drugs inhibiting the action of acetylcholine on structures innervated second time. Accordingly, their abuse potential is by postganglionic parasympathetic nerves (anti- very low or non-existent even though their psycho- muscarinic or atropinic drugs)) toxicity is quite high. 374. Isbell, H., Rosenberg, D. E., Miner, E. J. & Some of the antihistamines and benactyzine can, Logan, C. R. (1964) Neuropsychopharmacology, in high dose or in very susceptible persons, cause an 3, 440-446 (Tolerance and cross-tolerance to atropine-like psychosis."' 370, 371 scopolamine, N-ethyl-3-piperidyl benzilate (JB- 318) and LSD-25) 375. Lewin, L. (1964) Phantastica. Narcotic and stimulat- REFERENCES ing drugs [Translation from German] Routledge 370. Banshikov, V. M. & Stolarov, G. V. (1966) Zh. and Kegan Paul, London Nevropat. Psikhiat., 66, 464-468 (Psychotomime- 376. Pfeiffer, C. C. & Murphree, H. B. (1965) In: tic substances with anticholinergic action) DiPalma, J. R., ed., Drill's pharmacology in 371. Fink, M. & Itil, T. (1968) In: Efron, D. H., ed., medicine, 3rd ed., pp. 321-336, McGraw-Hill, Psychopharmacology. A review of progress New York (Chapter 22, Introduction to psycho- 1957-1967, pp. 1231-1239, Public Health Service tropic and hallucinogenic drugs) Publication No. 1836, US Government Printing 377. Vojt&hovsky, D., Krus, S., Grof, S., Vitek, V., Office, Washington, D.C. (Neurophysiology of Rysanek, K., Kunz, K. & Skala, J. (1967) In: phantastica: EEG and behavioral relations in Brill, H., ed., Neuro-psycho-pharmacology, pp. man) 388-389, Excerpta Medica Foundation, Amster- 372. Haen, P. de (1964) Drugs in research, P. de Haen, dam (Experimental psychoses induced by New York benactyzine in alcoholics) C' 0 0 U 0 C._ 0 C-' 0 C lO E00 It 0 0 z 4)0 r- 6 11 X< cocO E oZ 0 0z- M C U 0 z _ e ._ U 0 0 <a' z0 z0 CCC0 cZ E 0C) z D 0 o L) .0 ZCC__C CDO0 -J 0o Cu 00 1",o 0 'a~~~~~~~~~Z L. 0 I I IL CL 0 o 0 -_M a.-C 0 EC4 o11-L-E CO~~~~~~~~ZC CoDO00 WCu 0L 02 oEZ .2~~ ~ ~ ~~~~0 0- '= C .0Q OC~~~~~~~~~~~~~~~~~~~C CDW0. 0O 0 0C 0 t0 CD .C 0- -. - 0 0 0-r 0 0c 5 O @-0 o- u 0, o 0 -J L- 00~~~ ~ &.5 ~ 0 =..o 0 El0 0000 0 l C = O CU 0~~~~~~~~~~~: 0.0 E 0 Q CIA I C 0°0a 0 2sos0=CX 0 r0C o Z00 CD 0L0 00 0~ C 4) M 0. 0 aoo 0 0 0 -W 0 0 0.. z 1 0 E 0 (D O.-, E0 0 M 0 E. z COX -1- -a C.E 0 0 . c co -H ZCD- 2n co E- 0 co -J 0 mm,W -J OCQ .0 oI I L-. C0. 0 1 oE CsLI U-01 T0 a 0. 0 0 x CO:2E _:1 W E z a__ 0.Q -J Ut to - 93 . oco 0 03 C.' r- a) 0- CO C6 0) 0r-csc C. r- r- ,) C4 CO) U nCD uJ z 0 I U z z z U 00 0 0 z (D C o C 0 0 z I 4 Co 0o. 0 - CD r-0 oo 0 0C O 02Z coL 0 .C0 D CL E 0 M o r N- .2 zo 3 0 0 :5 0L0tc 0 -i E -J C . -iI CODC CD x .O- 04-' 0 C~~~~~~~~~~~~~~~~~~~~~C 0 *0 0 C Z0 ) I 0 U Ul) z-O Q~ z E - U x 't CD C 0 la E ._ Q . z r_Co I-O-I co c 0 0 0) 0 0 -J n 0.0 -m ,g 0 O 0. 0._L --I 20 N, = 0 Ch I E m 00 Un bo 0- u I O-C. 0. 0 1- E a ''r- ts I :ZIS 0 x 0 0. w 6 >O 0 -J z m co 0 NcmC" z 2 0) -94-.
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