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Toxicology Reference Material TOXICOLOGY REFERENCE MATERIAL Edition 2 Chiron AS Stiklestadvn. 1 N-7041 Trondheim NorwayPhone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA TOXICOLOGY Toxicology covers a wide range of disciplines, including therapeutic drug monitoring, clinical toxicology, forensic toxicology (drug driving, criminal and coroners), drugs in sport and work place drug testing, as well as academia and research. Those working in the field have a professional interest in the detection and measurement of alcohol, drugs, poisons and their breakdown products in biological samples, together with the interpretation of these measurements. Abuse and misuse of drugs is one of the biggest problems facing our society today. Acute poisoning remains one of the commonest medical emergencies, accounting for 10-20% of hospital admissions for general medicine [Dargan & Jones, 2001]. Many offenders charged with violent crimes, or victims of violent crime may have been under the influence of drugs at the time the act was committed. The use of mind-altering drugs in the work place, or whilst in control of a motor vehicle places others in danger [Drummer, 2001]. Performance enhancing drugs in sport make for an uneven playing field and distract from the core ethic of sportsmanship. Patterns of drug abuse around the world are constantly evolving. They vary between geographies; from one country to another and even from region to region or population to population within countries. With a European presence, a wide reaching network of global customers and distributors, and activate participation in relevant professional societies, Chiron is well positioned to develop and deliver relevant, and current standards to meet customer demand in this challenging field. Chiron AS Stiklestadvn. 1 N-7041 Trondheim NorwayPhone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA CONTENTS Introduction Single standards Amino acids 5 Amphetamines 5 Analgesics (non-opioid) 8 Anaesthetics 12 Antibiotics 12 Anticancer 17 Anticoagulants 17 Anticonvulsants / Antiepileptics 18 Antidepressants 20 Antidiabetics 24 Antidyskinetic / Antimuscarinics / Antiparkinsonian 25 Antiemetics 26 Antifungals 27 Antihistamines 27 Anti-impotence 28 Antimicrobial 28 Antiparasitic drugs (including anthelmintics, antimalarial and antiprotozoal drugs) 29 Antipsychotics 30 Antivirals 33 Alzheimers 33 Aryl cyclohexylamines 33 Barbiturates 34 Benzodiazepines 35 Benzofuries (APBs and APDBs) 41 Cannabinoids (Phyto) 42 Cannabinoids (Synthetic) 43 Cardiac drugs 57 Catecholamines 62 Cathinones 62 Cocaine & related compounds 69 Contrast media 70 Diarylethylamines 71 Dietary supplements / Appetite suppressants 71 Diuretics 72 Drugs for sleep disorders 72 Enzymes 74 Ephedrines 74 Ethanol & related compounds 75 Fentanyls 78 Gastrointestinal drugs 81 GHB & GBL 83 Indanes 83 Methamphetamines 84 Chiron AS Stiklestadvn. 1 N-7041 Trondheim NorwayPhone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA CONTENTS Methylenedioxyphenethylamines 85 Methylphenidate related compounds 86 Miscellaneous NPS 88 Nicotine & related compounds 89 Obstetrics 90 Opioids 90 2C Phenethylamines (psychedelics) 99 Piperazines 101 Plant chemicals 102 Quinazolinones 103 Respiratory agents (including methylxanthines) 103 Steroids & Hormones 104 Tryptamines 107 Vitamins 108 Drug mixtures Amphetamines 110 Analgesics 110 Anticonvulsants / Antiepileptics 110 Antidepressants & Antipsychotics 111 Antidiabetic drugs 111 Antifungals 111 Antihistamines 111 Anti-infectious drugs 112 Barbiturates 112 Benzodiazepines 112 Cannabinoids 113 Cardiac drugs 113 Catecholamines 113 Cocaine 113 Congener alcohols 113 Controlled substances 114 Fentanyls 114 Gastrointestinal drugs 114 Opiates & Opioids 114 Pharmaceutical residues 115 X-ray contrast media 116 Z-Drugs 116 Calibration sets Amphetamines & Opiates 117 Benzoylecgonine & Benzodiazepines 117 THC-acid 117 Zopiclone, Zolpidem & 6-MAM 117 Category Index 118 Chiron AS Stiklestadvn. 1 N-7041 Trondheim NorwayPhone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA 5 Single standards Catalogue No. Description (Abbreviation) Cas No. Conc. Solv. Vol. Amino acids 11826.3-K-HCL L-Alanine-3,3,3-d3 63546-27-0 1000 µg/mL 0.1 mol/L HCl 1 mL 12174.3-K-HCL DL-Alanine-13C3 1444476-54-0 1000 µg/mL 0.1 mol/L HCl 1 mL 11825.4-K-HCL L-Aspartic-2,3,3-d3 acid 3842-25-9 1000 µg/mL 0.1 mol/L HCl 1 mL 11878.4-K-HCL DL-Aspartic-2,3,3-d3 acid 14341-75-4 1000 µg/mL 0.1 mol/L HCl 1 mL 12175.4-K-HCL L-Aspartic acid-13C4-15N 202468-27-7 1000 µg/mL 0.1 mol/L HCl 1 mL 11830.6-K-HCL L-Citrulline-2,3,3,4,4,5,5-d7 372-75-8 (unlabelled) 1000 µg/mL 0.1 mol/L HCl 1 mL 11831.6-K-HCL DL-Cystine-2,2′,3,3,3′,3′-d6 352431-53-9 1000 µg/mL 0.1 mol/L HCl 1 mL 11822.6-K-HCL DL-Cystine-15N2 923-32-0 (unlabelled) 1000 µg/mL 0.1 mol/L HCl 1 mL 12592.12-10MG N-Acetyl-S-benzyl-2,3,4,5,6-d5-DL-cysteine 19538-71-7 (unlabelled) neat neat 10 mg 12593.11-K-HCL N-Acetyl-S-phenyl-d5-DL-cysteine 20640-68-0 (unlabelled) 1000 µg/mL 0.1 mol/L HCl 1 mL 11823.5-K-HCL L-Glutamic-2,3,3,4,4-d5 acid 2784-50-1 1000 µg/mL 0.1 mol/L HCl 1 mL 11828.5-K-HCL L-Glutamine-2,3,3,4,4-d5 14341-78-7 1000 µg/mL 0.1 mol/L HCl 1 mL 11827.2-K-HCL Glycine-d5 4896-77-9 1000 µg/mL 0.1 mol/L HCl 1 mL 1000 µg anhydrous 11838.6-K-HCL L-Histidine-d3 (α-d1; imidazole-2,5-d2) hydrochloride monohydrate 5934-29-2 (unlabelled) 0.1 mol/L HCl 1 mL acid/mL 11834.8-K-HCL DL-Homocystine-3,3,3′,3′,4,4,4′,4′-d8 108641-82-3 1000 µg/mL 0.1 mol/L HCl 1 mL 11820.6-K-HCL L-Leucine-d3 (methyl-d3) 87828-86-2 1000 µg/mL 0.1 mol/L HCl 1 mL 11837.6-K-HCL L-Lysine-3,3,4,4,5,5,6,6-d8 hydrochloride 344298-93-7 1000 µg acid/mL 0.1 mol/L HCl 1 mL 11821.5-K-HCL L-Methionine-3,3,4,4-d4 67866-75-5 1000 µg/mL 0.1 mol/L HCl 1 mL 11833.7-K-HCL Ntau-Methyl-d3-L-histidine 91037-48-8 1000 µg/mL 0.1 mol/L HCl 1 mL 11832.5-K-HCL L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride N/A 1000 µg acid/mL 0.1 mol/L HCl 1 mL 11818.9-K-HCL L-Phenyl-d5-alanine-2,3,3-d3 17942-32-4 1000 µg/mL 0.1 mol/L HCl 1 mL 11829.5-K-HCL L-Proline-2,5,5-d3 65807-22-9 1000 µg/mL 0.1 mol/L HCl 1 mL 11836.3-K-HCL L-Serine-d7 9355275-35-7 1000 µg/mL 0.1 mol/L HCl 1 mL 11835.4-K-HCL L-Threonine-2,3-d2 1202936-45-5 1000 µg/mL 0.1 mol/L HCl 1 mL 11817.11-K-HCL L-Tryptophan-2,3,3-d3 133519-78-5 1000 µg/mL 0.1 mol/L HCl 1 mL 11819.9-K-HCL L-Tyrosine-d4 62595-14-6 1000 µg/mL 0.1 mol/L HCl 1 mL 11824.5-K-HCL DL-Valine-d8 203784-63-8 1000 µg/mL 0.1 mol/L HCl 1 mL Amphetamines Amphetamine 9155.9-100-ME DL-Amphetamine 300-62-9 100 µg/mL methanol 1 mL 9155.9-K-ME DL-Amphetamine 300-62-9 1000 µg/mL methanol 1 mL 9155.9-10MG DL-Amphetamine 300-62-9 neat neat 10 mg 9155.9-50MG DL-Amphetamine 300-62-9 neat neat 50 mg 9155.9-100MG DL-Amphetamine 300-62-9 neat neat 100 mg 9156.9-100-ME DL-Amphetamine hydrochloride 2706-50-5 100 µg base/mL methanol 1 mL 9156.9-K-ME DL-Amphetamine hydrochloride 2706-50-5 1000 µg base/mL methanol 1 mL 9156.9-10MG DL-Amphetamine hydrochloride 2706-50-5 neat neat 10 mg 9156.9-50MG DL-Amphetamine hydrochloride 2706-50-5 neat neat 50 mg 9156.9-100MG DL-Amphetamine hydrochloride 2706-50-5 neat neat 100 mg 9201.9-100-ME D-Amphetamine hydrochloride 1462-73-3 100 µg base/mL methanol 1 mL 9201.9-K-ME D-Amphetamine hydrochloride 1462-73-3 1000 µg base/mL methanol 1 mL 9200.9-100-ME L-Amphetamine hydrochloride 41820-21-7 100 µg base/mL methanol 1 mL 9200.9-K-ME L-Amphetamine hydrochloride 41820-21-7 1000 µg base/mL methanol 1 mL 9157.9-100-ME DL-Amphetamine sulfate (1/2 sulfate per amphetamine) 60-13-9 100 µg base/mL methanol 1 mL 9157.9-K-ME DL-Amphetamine sulfate (1/2 sulfate per amphetamine) 60-13-9 1000 µg base/mL methanol 1 mL 9157.9-10MG DL-Amphetamine sulfate (1/2 sulfate per amphetamine) 60-13-9 neat neat 10 mg 9157.9-50MG DL-Amphetamine sulfate (1/2 sulfate per amphetamine) 60-13-9 neat neat 50 mg 9157.9-100MG DL-Amphetamine sulfate (1/2 sulfate per amphetamine) 60-13-9 neat neat 100 mg 11654.9-100-ME D-Amphetamine sulphate (1/2 sulfate per amphetamine) 51-63-8 100 µg base/mL methanol 1 mL 11654.9-K-ME D-Amphetamine sulphate (1/2 sulfate per amphetamine) 51-63-8 1000 µg base/mL methanol 1 mL Chiron AS Stiklestadvn.
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