What Is Synthetic Biology?

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What Is Synthetic Biology? ETC Group Heinrich Böll Stiftung ...works to address the socioeconomic Fostering democracy and upholding and ecological issues surrounding new human rights, taking action to prevent technologies that could have an impact the destruction of the global ecosystem, on the world’s poorest and most advancing equality between women and vulnerable people. We investigate men, securing peace through conflict ecological erosion (including the erosion prevention in crisis zones, and defending of cultures and human rights); the the freedom of individuals against development of new technologies excessive state and economic power – (especially agricultural but also other these are the objectives that drive the technologies that work with genomics ideas and actions of the Heinrich Böll and matter); and we monitor global Foundation. We maintain close ties to governance issues including corporate the German Green Party (Alliance 90 / concentration and trade in technologies. The Greens) and as a think tank for We operate at the global political level. green visions and projects, we are part of We work closely with partner civil an international network encompassing society organizations (CSOs) and social well over 100 partner projects in movements, especially in Africa, approximately 60 countries. Asia and Latin America. The Heinrich Böll Foundation works www.etcgroup.org independently and nurtures a spirit of intellectual openness. We maintain a Extreme Biotech Meets Extreme Energy world­wide network with currently is ETC communique #113. 32 international offices. We cooperate closely with 16 state-level Böll Original Research by ETC Group with Foundations in each of Germany’s the financial support and collaboration federal states, and we support talented, of the Heinrich Böll Foundation. socio-politically engaged undergraduate Copy-editing and proof-reading: and graduate students in Germany and Holly Dressel abroad. We gladly follow Heinrich Böll’s Design and artwork by Stig exhortation for citizens to get involved First Published November 2015. in politics, and we want to inspire others CC-BY-NC-ND – Attribution- to do the same. NonCommercial-NoDerivs 3.0 www.boell.de/en 2 Extreme Biotech meets Extreme Energy Issue Fora The extreme genetic engineering industry of Synthetic Biology At the nation-state level, the US (Syn Bio) is rapidly shrugging off earlier pretensions that it Government’s Department of Energy is might usher in a clean, green, post-petroleum future. Instead, actively convening and funding research many Syn Bio executives and start-ups are now trying to create work on Synthetic Biology for the benefit of alliances with fracking, oil and shale interests, which will the extractive fossil industries. However, no actually increase the fossil–based extractive economy that has international policy discussion has yet taken already brought planetary climate change and other ecological place as to the implications of this shift and social problems. New Syn Bio-enabled techniques of towards supporting fossil fuel extraction in “gaseous fermentation” allow for natural gas to be the SynBio Industry. In particular, the transformed into fuels, chemicals, plastics and societal and ecological challenge of possibly even proteins, adding even more value to As the extreme new biotechnologies propping the gas coming from oilfields and frackfields and biotech industry and the up the aging fossil fuel industry potentially making economical the 40-60% of extreme extraction industry has not been discussed in the global gas reserves currently lost or “stranded” move towards deeper vital context of climate (gas that is not currently economically collaboration, biosafety risks and negotiations. Despite this, in recoverable). At the same time, fossil producers climate risks emanating from an on going process, the 194 are becoming intrigued by the possibility that both will start to become parties to the UN Convention applying engineered microbes to existing wells and ever more entangled. on Biological Diversity (CBD) coal seams could enable them to access more of the 2 have passed several precautionary to 4 trillion barrels of oil in existing oil fields, oil that has international decisions urging proper been considered inaccessible. Pumping microbes into oilfields is regulation and assessment. The topic of a technological gamble that might expand global oil reserves by Synthetic Biology returns to the CBD’s 150% if it pays off, and it could also liberate more gas from coal SBSTTA (scientific and technical body) in reserves. As the extreme biotech industry and the extreme April 2016. extraction industry move towards deeper collaboration, biosafety risks and climate risks emanating from both will start Policy to become ever more entangled. Most urgently, a dialogue needs to get Actors underway between movements opposing fossil fuel extraction and expansion (e.g. anti- A rash of Syn Bio start-ups and more established biotech firms fracking or anti-pipeline), and those tracking making fuels and chemicals are switching their feedstocks (the developments in biotech. Civil society material the engineered bacteria eat) from biomass to natural organizations could recommend a gas; they have been encouraged and subsidised to do this by the moratorium on the environmental release US Department of Energy. More established companies in this and commercialisation of Synthetic Biology “dash to gas” include Calysta, Intrexon, Coskata and Lanzatech. applications, which would include A leading bioplastic company, Natureworks, is also switching to applications in the extractive industry sector. a Syn Bio/gas feedstock plan. Meanwhile, nascent oil company In climate negotiations, civil society and interest in pumping engineered organisms into extraction sites policymakers should be vigilant that neither appears to be led by BP and Du Pont, with smaller actors also the capture of stranded gas for Syn Bio pioneering the field. They include Craig Venter’s Synthetic transformation nor the use of MEHR Genomics Inc., and California’s Taxon Biosciences. There is less (Microbially Enhanced Hydrocarbon interest so far in applying Synthetic Biology to mine for non- Recovery) are misleadingly promoted as a fossil minerals, but this is still under development, with San climate solution, and moreover that the very Francisco’s Universal Mining as the standout pre-commercial considerable climate and biodiversity risks of player. these techniques are very clear to all parties. ETC Group & Heinrich Böll Stiftung 3 Introduction Modified Climates and Modified Microbes - Two Bad Ideas Find Each Other A quarter century ago, in his groundbreaking book The These techniques have evolved with such speed and depth End of Nature, ecological writer Bill McKibben pointed out of intervention that there are as yet few methods (to say that humans were now interfering with nature in two nothing of regulatory bodies), with which to begin to fundamental ways.2 The prime subject of his safely assess their impacts on the natural book was that the burning of fossil fuels is genomes they will invade. Roboticised altering Earth’s atmosphere, creating an “Why then does it genetic engineering platforms now unnatural climatic state everywhere (genetic modification) sound enable Syn Bio companies to generate on the planet. The second “end of so awful? Because of course it tens of thousands of novel species at nature” was that humans were for represents the second end of nature. one go, releasing these constructs, the first time crossing natural We have already, pretty much by whose effects on the evolution of species barriers, intentionally accident, altered the atmosphere so badly Earth's lifeforms are completely altering the genetic code of living that nature as we know it is over. But unknown. This amounts to organisms through genetic this won’t be by accident – this will be intervening in evolution itself at an engineering. on purpose.” unprecedented scale and speed. As the planet’s atmosphere, now - Bill McKibben, The End And now, these two “end of nature” 1 loaded with carbon dioxide to over 400 of Nature scenarios are becoming synergistic. As the parts per million, inexorably warms towards a multibillion dollar Synthetic Biology industry dangerous 2 degree centigrade average temperature rise, searches for viable products, new markets and new funding, more and more civil society, climate scientists and a number of private companies and even some governments governments are reaching the logical conclusion that only a are seizing on the idea of using the extreme genetic serious phase-out and winding down of the global engineering of Syn Bio to further extreme energy extraction extractive fossil fuel economy can safely ward off dangerous in the fossil fuel economy. This is a potent and potentially climate change. Part of preventing fossil expansion means lethal synergy; it combines the biosafety risks of synthetic striking out any policies, proposals or technologies that biology with the climate risks of fossil fuel extraction. would increase the extraction of fossil fuels, including new The new alliance, unfortunately, makes excellent “extreme energy” approaches such as fracking, coal bed economic sense for the carbon majors,3 that is, the large methane recovery, deep water drilling, shale oil mining and coal, gas and oil companies who have been most enhanced oil recovery. Given the planet's current responsible for human-made climate change. These warming state, developing and deploying these hugely powerful
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