Anti-CCAR1 (Aa 901-912) Polyclonal Antibody (DPABH-19950) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CCAR1 (aa 901-912) polyclonal antibody (DPABH-19950) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.

Immunogen Synthetic peptide: RYCKERPSKDKE, corresponding to internal sequence (near C-Terminus) amino acids 901-912 of Human DIS (NP_060707.2).

Isotype IgG

Source/Host Goat

Species Reactivity Mouse, Rat

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 100 μg

Buffer Constituents: 0.5% BSA, Tris buffered saline, pH 7.3

Preservative 0.02% Sodium Azide

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol CCAR1

Synonyms CCAR1; cell division cycle and apoptosis regulator 1; cell division cycle and apoptosis regulator protein 1; death inducer with SAP domain; cell cycle and apoptosis regulatory protein 1;

Entrez Gene ID 55749

Protein Refseq NP_001269888.1

UniProt ID Q8IX12

Pathway Gene Expression; mRNA Splicing;

Function ligand-dependent nuclear receptor transcription coactivator activity; poly(A) RNA binding; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]