Anti-CCAR1 (aa 901-912) polyclonal antibody (DPABH-19950) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Immunogen Synthetic peptide: RYCKERPSKDKE, corresponding to internal sequence (near C-Terminus) amino acids 901-912 of Human DIS (NP_060707.2). Isotype IgG Source/Host Goat Species Reactivity Mouse, Rat Purification Immunogen affinity purified Conjugate Unconjugated Applications WB Format Liquid Size 100 μg Buffer Constituents: 0.5% BSA, Tris buffered saline, pH 7.3 Preservative 0.02% Sodium Azide Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name CCAR1 cell division cycle and apoptosis regulator 2 [ Homo sapiens ] Official Symbol CCAR1 Synonyms CCAR1; cell division cycle and apoptosis regulator 1; cell division cycle and apoptosis regulator protein 1; death inducer with SAP domain; cell cycle and apoptosis regulatory protein 1; Entrez Gene ID 55749 Protein Refseq NP_001269888.1 UniProt ID Q8IX12 Pathway Gene Expression; mRNA Splicing; Function ligand-dependent nuclear receptor transcription coactivator activity; poly(A) RNA binding; protein binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.