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From Syringe to Autoinjector Volume 40 Number 6 Blow-Fill-Seal Data Integrity Using Modular JUNE 2016 Volume 40 Number 6 PLUS: Technology Training Construction PHARMACEUTICAL TECHNOLOGY From Syringe to JUNE 2016 2016 JUNE Autoinjector Building a Better Self-Injection Solution PharmTech.com PEER-REVIEWED Qualifying Personnel to Visually Inspect Cleaned Equipment, Part II SINGLE -USE SYSTEMS FORMULATION API SYNTHESIS & MANUFACTURING Integrating Single-Use Systems Customizing HPMC Adoption of Continuous Processing Advancing Drug Delivery Through Superior Polymer Design Safe and effective delivery of today’s complex drug molecules is increasingly a function of collaboration between polymer experts and pharmaceutical product development teams. Acting on enabling science, producing superior polymer excipient technology, and creating systems for optimum bioavailability, Ashland works alongside formulators to advance drug- specific delivery platforms. Explore how you can solve intricate drug formulation and development challenges with polymer expertise from Ashland. Visit us at Ashland.com/pharmaceutical Come visit us at Booth 610 Ashland [email protected] www.ashland.com/pharmaceutical ®Registered trademark, Ashland or its subsidiaries, registered in various countries ™Trademark, Ashland or its subsidiaries, registered in various countries ©2016, Ashland AD-13475.1 “Off-the-shelf solutions? No thank you. After all, our customers are something special.” Daniel Drossel Mechanical Engineering Technician (Design department) Each customer has its very own special requirements. That’s why we, at Optima, manufacture fi lling lines that are fi ne-tuned to our clients’ particular needs while off ering the benefi ts of an integrated and complete line: The complete machine package including high-precision functionalities, backed by consistent documentation and supported by an optimized and tailored software solution – in addition to a central point of contact who is passionate about your every concern… We are experts in special solutions, after all. Member of OPTIMA pharma GmbH | 74523 Schwaebisch Hall | Germany | www.optima-pharma.com OPTIMA Machinery Corporation | Green Bay, WI, 54304 | USA | www.optima-usa.com EDITORIAL SALES Editorial Director Rita Peters [email protected] Senior Editor Agnes Shanley [email protected] Publisher Mike Tracey [email protected] Managing Editor Susan Haigney [email protected] Mid-West Sales Manager Irene Onesto [email protected] Science Editor Adeline Siew, PhD [email protected] East Coast Sales Manager Joel Kern [email protected] Manufacturing Editor Jennifer Markarian [email protected] Science Editor Randi Hernandez [email protected] European Sales Manager Linda Hewitt [email protected] Community Manager Caroline Hroncich [email protected] European Senior Sales Executive Stephen Cleland [email protected] Art Director Dan Ward Executive Assistant Barbara Sefchick [email protected] Contributing Editors Jill Wechsler [email protected]; Jim Miller [email protected]; Hallie Forcinio [email protected]; Susan J. 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