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( 12 ) United States Patent US009770430B2 (12 ) United States Patent (10 ) Patent No. : US 9 ,770 ,430 B2 Chevion et al . (45 ) Date of Patent: Sep . 26 , 2017 ( 54 ) DESFERRIOXAMINE -METAL COMPLEXES Banin , et al. , Gallium - Desferrioxamine Protects the Cat Retina FOR THE TREATMENT OF Against Injury After Ischemia and Reperfusion , Free Radical Biol ogy and Medicine , 2000 , pp . 315 - 323, vol. 28 , No . 3 . IMMUNE -RELATED DISORDERS Banin , et al. , The potential of desferrioxamine - gallium as an anti (71 ) Applicant : Mordechai Chevion , Mevasseret Zion Pseudomonas therapeutic agent , PNAS , Oct. 28 , 2008 , pp . 16761 16766 , vol. 105, No . 43 . ( IL ) Bar - On , et al ., Hyperlipoproteinemia in Streptozotocin - treated Rats , (72 ) Inventors : Mordechai Chevion , Mevasseret Zion Diabetes , Jun . 1976 , pp . 509 - 515 , vol . 25 . ( IL ) ; Vladimir Vinokur , BeerSheeva Chevion , A Site - Specific Mechanism for Free Radical Induced Biological Damage: The Essential Role of Redox - Active Transition ( IL ) ; Eduard Berenshtein , Jerusalem Metals , Free Radical Biology & Medicine , 1988 , pp . 27 - 37 , vol. 5 . ( IL ) ; Ron Eliashar , Har - Adar ( IL ) ; Chevion , Protection Against Free Radical - Induced and Transition Baruch Bulvik , Elazar ( IL ) Metal -Mediated Damage : The Use of “ Pull” and “ Push ” Mecha nisms, Free Rad . Res . Comms. , 1991, pp . 691 -696 , vols . 12 - 13 . ( * ) Notice: Subject to any disclaimer, the term of this Chevion , et al. , Copper and iron are mobilized following myocardial patent is extended or adjusted under 35 ischemia : Possible predictive criteria for tissue injury , Proc . Natl . U . S . C . 154 (b ) by 0 days . Acad . Sci. USA , Feb . 1993 , pp . 1102 - 1106 , vol . 90 . Chevion , et al ., The Role of Transition Metal Ions in Free Radical (21 ) Appl . No .: 14 /606 ,453 Mediated Damage , Reactive Oxygen Species in Biological Sys (22 ) Filed : Jan . 27 , 2015 tems, 1999 , pp . 103 - 131, Colton , G . A . ( ed . ) Plenum Press , New York . (65 ) Prior Publication Data Kennedy, et al. , Objective and Subjective Outcomes in Surgery for Chronic Sinusitis , Laryngoscope , Mar. 2000 , pp . 29 - 31 , vol. 110 . US 2015 /0148413 A1 May 28 , 2015 Kostopanagiotou , et al ., Desferrioxamine attenuates minor lung injury following surgical acute liver failure , Eur. Respir. J ., 2009 , Related U . S . Application Data pp . 1429 - 1436 , vol. 33 . (62 ) Division of application No . 13/ 390 , 838 , filed as Kung, et al ., Characterization of a Murine Model of Allergic application No . PCT/ IL 2010 / 000681 on Aug . 19 , Pulmonary Inflammation , Int Arch Allergy Immunol, 1994 , pp . 83 - 90 , vol. 105 . 2010 , now Pat . No . 8 , 975 ,294 . Lalonde , et al. , Aerosolized deferoxamine prevents lung and sys (60 ) Provisional application No. 61 /347 , 617 , filed on May temic injury caused by smoke inhalation , Journal of Applied Physi 24 , 2010 , provisional application No . 61/ 298 , 596 , ology, 1994 , pp . 2057 - 2064 , vol. 77 , No. 5 . filed on Jan . 27 , 2010 , provisional application No . Lund, et al. , Staging in rhinosinusitus , Rhinology , 1993 , pp . 183 184 , vol. 31 . 61/ 235 , 062, filed on Aug . 19 , 2009 . Matsui , et al. , The Effect of Antioxidants on Ozone - induced Airway (51 ) Int. Ci. Hyperresponsiveness in Dogs, The American Review of Respira tory Disease , 1991 , pp . 1287 - 1290 , vol. 144 , No . 6 . A61K 31/ 28 ( 2006 .01 ) Meltzer , et al. , Rhinosinusitis : Establishing definitions for clinical A61K 31 /315 ( 2006 .01 ) research and patient care , Supplement to The Journal of Allergy and (52 ) U . S . CI. Clinical Immunology , Dec . 2004 , pp . S155 -S212 , vol . 114 , No. 6 . CPC . .. A61K 31 /315 (2013 .01 ) ; A61K 31/ 28 Misawa , et al ., Airway inflammation induced by xanthine / xanthine (2013 .01 ) oxidase in guinea pigs , Agents Actions, 1993 , pp . 19 - 26 , vol. 38 , ( 58 ) Field of Classification Search No . 1 - 2 . CPC . .. .. A61K 31 / 315 Moskovitz , et al. , Methionine sulfoxide reductase (MsrA ) is a regulator of antioxidant defense and lifespan in mammals , PNAS , USPC .. .. .. .. .. .. 514 /492 , 494 , 826 , 866 , 885 Nov . 6 , 2001 , pp . 12920 - 12925 , vol. 98 , No . 23 . See application file for complete search history. Moskovitz , et al. , The yeast peptide- methionine sulfoxide reductase functions as an antioxidant in vivo , Proc . Natl . Acad . Sci. USA , Sep . ( 56 ) References Cited 1997 , pp . 9585 - 9589 , vol. 94 . Muluk , et al. , Role of Vascular Endothelial Growth Factor in the U . S . PATENT DOCUMENTS Pathogenesis of Nasal Polyps, The Journal of Otolaryngology, Dec . 5 , 227 , 405 A 7 / 1993 Fridovich et al . 2007 , pp . 357 - 366 , vol. 36 , No . 6 . 6 , 269 ,818 B1 8 / 2001 Lui et al. 128 / 898 (Continued ) 2008 /0085866 A1 4 / 2008 Greenberg et al. Primary Examiner — Kevin E Weddington FOREIGN PATENT DOCUMENTS ( 74 ) Attorney , Agent, or Firm — Mordechai Chevion AU WO 2008061299 A1 * 5 /2008 . A61K 31 / 16 EP 0 284 645 10 / 1988 ( 57 ) ABSTRACT EP 0 409 452 1 / 1991 The present invention relates to methods kits and combined WO 94 / 26263 11 / 1994 compositions using DFO -metal complexes, specifically , WO 95/ 00140 1 / 1995 WO 02 / 102345 12 / 2002 Zinc - desferrioxamine ( Zn -DFO ) , gallium -desferrioxamine WO 2004 / 060490 7 / 2004 (Ga - DFO ) complexes and any combinations thereof for WO 2005 /000224 1 / 2005 preventing , treating , ameliorating or inhibiting an immune related disorder, specifically , a skin - related inflammatory OTHER PUBLICATIONS disorder such as psoriasis , an inflammatory respiratory con dition such as asthma , and an autoimmune disease such as Schaal et al. , “ Desferrioxamine and zinc -desferrioxamine reduce diabetes and any immune -related disorder. lens oxidative damage ” , Experimental Eye Research , vol. 83 , No. 4 , pp . 561 - 568 ( 2007) . * 17 Claims, 19 Drawing Sheets US 9 ,770 ,430 B2 Page 2 ( 56 ) References Cited OTHER PUBLICATIONS Ophir, et al. , Protection of the Transiently Ischemic Cat Retina by Zinc -Desferrioxamine , Invest Ophthalmol Vis Sci. , 1994 , pp . 1212 1222 , vol. 35 . Reagan - Shaw , et al . , Dose translation from animal to human studies revisited , The FASEB Journal , 2007 , pp . 659 -661 , vol. 22 . Renstrom , et al . , Allergic sensitization is associated with increased bronchial responsiveness : a prospective study of allergy to labora tory animals , Eur Respir J , 1995 , pp . 1514 - 1519 , vol . 8 . Siganos, et al. , Topical Use of Zinc Desferrioxamine for Corneal Alkali Injury in a Rabbit Model, Cornea , 1998 , pp . 191 - 195 , vol. 17 ( 2 ) . Author unknown, Psoriasis , U . S . National Institutes of Health Medical Encyclopedia , www .nlm . nih . gov /medlineplus / ency /article / 000434 .htm , 2013 , pp . 1 - 4 . Wei , et al ., The Streptozotocin -Diabetic Rat as a Model of the Chronic Complications of Human Diabetes , Heart , Lung and Cir culation , 2003 , pp . 44 - 50 , vol. 12 . Wu , et al. , Desferrioxamine modulates chemically induced T helper 2 -mediated autoimmunity in the rat, Clin Exp Immunol , 2004 , pp . 194 - 199 , vol . 135 . 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