US009770430B2 (12 ) United States Patent (10 ) Patent No. : US 9 ,770 ,430 B2 Chevion et al . (45 ) Date of Patent: Sep . 26 , 2017 ( 54 ) DESFERRIOXAMINE -METAL COMPLEXES Banin , et al. , Gallium - Desferrioxamine Protects the Cat Retina FOR THE TREATMENT OF Against Injury After Ischemia and Reperfusion , Free Radical Biol ogy and Medicine , 2000 , pp . 315 - 323, vol. 28 , No . 3 . IMMUNE -RELATED DISORDERS Banin , et al. , The potential of desferrioxamine - gallium as an anti (71 ) Applicant : Mordechai Chevion , Mevasseret Zion Pseudomonas therapeutic agent , PNAS , Oct. 28 , 2008 , pp . 16761 16766 , vol. 105, No . 43 . ( IL ) Bar - On , et al ., Hyperlipoproteinemia in Streptozotocin - treated Rats , (72 ) Inventors : Mordechai Chevion , Mevasseret Zion Diabetes , Jun . 1976 , pp . 509 - 515 , vol . 25 . 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PATENT DOCUMENTS Pathogenesis of Nasal Polyps, The Journal of Otolaryngology, Dec . 5 , 227 , 405 A 7 / 1993 Fridovich et al . 2007 , pp . 357 - 366 , vol. 36 , No . 6 . 6 , 269 ,818 B1 8 / 2001 Lui et al. 128 / 898 (Continued ) 2008 /0085866 A1 4 / 2008 Greenberg et al. Primary Examiner — Kevin E Weddington FOREIGN PATENT DOCUMENTS ( 74 ) Attorney , Agent, or Firm — Mordechai Chevion AU WO 2008061299 A1 * 5 /2008 . A61K 31 / 16 EP 0 284 645 10 / 1988 ( 57 ) ABSTRACT EP 0 409 452 1 / 1991 The present invention relates to methods kits and combined WO 94 / 26263 11 / 1994 compositions using DFO -metal complexes, specifically , WO 95/ 00140 1 / 1995 WO 02 / 102345 12 / 2002 Zinc - desferrioxamine ( Zn -DFO ) , gallium -desferrioxamine WO 2004 / 060490 7 / 2004 (Ga - DFO ) complexes and any combinations thereof for WO 2005 /000224 1 / 2005 preventing , treating , ameliorating or inhibiting an immune related disorder, specifically , a skin - related inflammatory OTHER PUBLICATIONS disorder such as psoriasis , an inflammatory respiratory con dition such as asthma , and an autoimmune disease such as Schaal et al. , “ Desferrioxamine and zinc -desferrioxamine reduce diabetes and any immune -related disorder. lens oxidative damage ” , Experimental Eye Research , vol. 83 , No. 4 , pp . 561 - 568 ( 2007) . * 17 Claims, 19 Drawing Sheets US 9 ,770 ,430 B2 Page 2 ( 56 ) References Cited OTHER PUBLICATIONS Ophir, et al. , Protection of the Transiently Ischemic Cat Retina by Zinc -Desferrioxamine , Invest Ophthalmol Vis Sci. , 1994 , pp . 1212 1222 , vol. 35 . Reagan - Shaw , et al . , Dose translation from animal to human studies revisited , The FASEB Journal , 2007 , pp . 659 -661 , vol. 22 . Renstrom , et al . , Allergic sensitization is associated with increased bronchial responsiveness : a prospective study of allergy to labora tory animals , Eur Respir J , 1995 , pp . 1514 - 1519 , vol . 8 . Siganos, et al. , Topical Use of Zinc Desferrioxamine for Corneal Alkali Injury in a Rabbit Model, Cornea , 1998 , pp . 191 - 195 , vol. 17 ( 2 ) . Author unknown, Psoriasis , U . S . National Institutes of Health Medical Encyclopedia , www .nlm . nih . gov /medlineplus / ency /article / 000434 .htm , 2013 , pp . 1 - 4 . Wei , et al ., The Streptozotocin -Diabetic Rat as a Model of the Chronic Complications of Human Diabetes , Heart , Lung and Cir culation , 2003 , pp . 44 - 50 , vol. 12 . Wu , et al. , Desferrioxamine modulates chemically induced T helper 2 -mediated autoimmunity in the rat, Clin Exp Immunol , 2004 , pp . 194 - 199 , vol . 135 . 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