The Effects of Trauma on Brain and Behavior
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Cerebral Cortex Structure, Function, Dysfunction Reading Ch 10 Waxman Dental Neuroanatomy Lecture Suzanne Stensaas, Ph.D
Cerebral Cortex Structure, Function, Dysfunction Reading Ch 10 Waxman Dental Neuroanatomy Lecture Suzanne Stensaas, Ph.D. March 15, 2011 Anatomy Review • Lobes and layers • Brodmann’s areas • Vascular Supply • Major Neurological Findings – Frontal, Parietal, Temporal, Occipital, Limbic • Quiz Questions? Types of Cortex • Sensory • Motor • Unimodal association • Multimodal association necessary for language, reason, plan, imagine, create Structure of neocortex (6 layers) The general pattern of primary, association and mulimodal association cortex (Mesulam) Brodmann, Lateral Left Hemisphere MCA left hemisphere from D.Haines ACA and PCA -Haines Issues of Functional Localization • Earliest studies -Signs, symptoms and note location • Electrical discharge (epilepsy) suggested function • Ablation - deficit suggest function • Reappearance of infant functions suggest loss of inhibition (disinhibition), i.e. grasp, suck, Babinski • Variabilities in case reports • Linked networks of afferent and efferent neurons in several regions working to accomplish a task • Functional imaging does not always equate with abnormal function associated with location of lesion • fMRI activation of several cortical regions • Same sign from lesions in different areas – i.e.paraphasias • Notion of the right hemisphere as "emotional" in contrast to the left one as "logical" has no basis in fact. Limbic System (not a true lobe) involves with cingulate gyrus and the • Hippocampus- short term memory • Amygdala- fear, agression, mating • Fornix pathway to hypothalamus • -
Lateralization of Function Human Brain
Lateralization of Function Dr. Coulson Cognitive Science Department UCSD Human Brain • An extension of the spinal cord 1 Cerebral Hemispheres Corpus Callosum 2 Cartoon View of Brain Cerebral Lobes 3 Neurons • Brain composed of neurons – 100 billion • Neurons both send and receive signals to other cells in form of pulses • Important parts – Cell body –Axon – Synapse Connectivity • Each neuron connected to 10,000 other neurons • Point of contact is the synapse • Computing power of brain comes from connections 4 Cortex • Two millimeters thick and has area of 1.5 square meters Cartoon View: Frontal Lobe • In front of central sulcus • Decisions, judgments, emotions 5 Cartoon View: Parietal Lobe • Behind central sulcus • Perception of stimuli related to touch, pressure, temperature, pain Cartoon View: Temporal Lobe • Below lateral fissure • Perception, recognition, auditory processing 6 Cartoon View: Occipital Lobe • Located at back of brain, behind the parietal lobe and temporal lobe • Vision Lateralization of Function • One side of the brain is more crucial for a given function and/or more efficient at the underlying computational tasks • Typically a matter of degree – Strongly vs. Weakly Lateralized • Motor control a good example of a lateralized function 7 Sensorimotor Cortex 8 Motor Control What about language? • Language is a paradigmatic example of a lateralized cognitive phenomenon 9 Wada Test Lateralization of Function • Most evidence of lateralized brain function comes from observing how brain damage affects behavior on various sorts -
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection This guide is for middle and high school students participating in AIMS Anatomy of the Human Brain and Sheep Brain Dissections. Programs will be presented by an AIMS Anatomy Specialist. In this activity students will become more familiar with the anatomical structures of the human brain by observing, studying, and examining human specimens. The primary focus is on the anatomy, function, and pathology. Those students participating in Sheep Brain Dissections will have the opportunity to dissect and compare anatomical structures. At the end of this document, you will find anatomical diagrams, vocabulary review, and pre/post tests for your students. The following topics will be covered: 1. The neurons and supporting cells of the nervous system 2. Organization of the nervous system (the central and peripheral nervous systems) 4. Protective coverings of the brain 5. Brain Anatomy, including cerebral hemispheres, cerebellum and brain stem 6. Spinal Cord Anatomy 7. Cranial and spinal nerves Objectives: The student will be able to: 1. Define the selected terms associated with the human brain and spinal cord; 2. Identify the protective structures of the brain; 3. Identify the four lobes of the brain; 4. Explain the correlation between brain surface area, structure and brain function. 5. Discuss common neurological disorders and treatments. 6. Describe the effects of drug and alcohol on the brain. 7. Correctly label a diagram of the human brain National Science Education -
Anatomy of the Temporal Lobe
Hindawi Publishing Corporation Epilepsy Research and Treatment Volume 2012, Article ID 176157, 12 pages doi:10.1155/2012/176157 Review Article AnatomyoftheTemporalLobe J. A. Kiernan Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada N6A 5C1 Correspondence should be addressed to J. A. Kiernan, [email protected] Received 6 October 2011; Accepted 3 December 2011 Academic Editor: Seyed M. Mirsattari Copyright © 2012 J. A. Kiernan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Only primates have temporal lobes, which are largest in man, accommodating 17% of the cerebral cortex and including areas with auditory, olfactory, vestibular, visual and linguistic functions. The hippocampal formation, on the medial side of the lobe, includes the parahippocampal gyrus, subiculum, hippocampus, dentate gyrus, and associated white matter, notably the fimbria, whose fibres continue into the fornix. The hippocampus is an inrolled gyrus that bulges into the temporal horn of the lateral ventricle. Association fibres connect all parts of the cerebral cortex with the parahippocampal gyrus and subiculum, which in turn project to the dentate gyrus. The largest efferent projection of the subiculum and hippocampus is through the fornix to the hypothalamus. The choroid fissure, alongside the fimbria, separates the temporal lobe from the optic tract, hypothalamus and midbrain. The amygdala comprises several nuclei on the medial aspect of the temporal lobe, mostly anterior the hippocampus and indenting the tip of the temporal horn. The amygdala receives input from the olfactory bulb and from association cortex for other modalities of sensation. -
Visual Cortex in Humans 251
Author's personal copy Visual Cortex in Humans 251 Visual Cortex in Humans B A Wandell, S O Dumoulin, and A A Brewer, using fMRI, and we discuss the main features of the Stanford University, Stanford, CA, USA V1 map. We then summarize the positions and proper- ties of ten additional visual field maps. This represents ã 2009 Elsevier Ltd. All rights reserved. our current understanding of human visual field maps, although this remains an active field of investigation, with more maps likely to be discovered. Finally, we Human visua l cortex comprises 4–6 billion neurons that are organ ized into more than a dozen distinct describe theories about the functional purpose and functional areas. These areas include the gray matter organizing principles of these maps. in the occi pital lobe and extend into the temporal and parietal lobes . The locations of these areas in the The Size and Location of Human Visual intact human cortex can be identified by measuring Cortex visual field maps. The neurons within these areas have a variety of different stimulus response proper- The entirety of human cortex occupies a surface area 2 ties. We descr ibe how to measure these visual field on the order of 1000 cm and ranges between 2 and maps, their locations, and their overall organization. 4 mm in thickness. Each cubic millimeter of cortex contains approximately 50 000 neurons so that neo- We then consider how information about patterns, objects, color s, and motion is analyzed and repre- cortex in the two hemispheres contain on the order of sented in these maps. -
Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans Ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai
Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai To cite this version: Hans ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai. Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex. Frontiers in Neuroanatomy, Frontiers, 2018, 12, pp.93. 10.3389/fnana.2018.00093. hal-01929541 HAL Id: hal-01929541 https://hal.archives-ouvertes.fr/hal-01929541 Submitted on 21 Nov 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. REVIEW published: 19 November 2018 doi: 10.3389/fnana.2018.00093 Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans J. ten Donkelaar 1*†, Nathalie Tzourio-Mazoyer 2† and Jürgen K. Mai 3† 1 Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands, 2 IMN Institut des Maladies Neurodégénératives UMR 5293, Université de Bordeaux, Bordeaux, France, 3 Institute for Anatomy, Heinrich Heine University, Düsseldorf, Germany The gyri and sulci of the human brain were defined by pioneers such as Louis-Pierre Gratiolet and Alexander Ecker, and extensified by, among others, Dejerine (1895) and von Economo and Koskinas (1925). -
The Brain Is Contained Within the Cranium, and Constitutes the Upper, Greatly Expanded Part of the Central Nervous System
The brain is contained within the cranium, and constitutes the upper, greatly expanded part of the central nervous system. Henry Gray (1918) Looking through the gray outer layer of the cortex, you can see a mass of white matter. At the center is a cluster of large nuclei, including the basal ganglia, the hippocampi, the amygdalae, and two egg-shaped structures at the very center, barely visible in this figure, the thalami. The thalami rest on the lower brainstem (dark and light blue). You can also see the pituitary gland in front (beige), and the cerebellum at the rear of the brain (pink). In this chapter we will take these structures apart and re-build them from the bottom up. 09_P375070_Ch05.indd 126 1/29/2010 4:08:25 AM CHAPTER 5 The brain OUTLINE 1.0 Introduction 127 3.2 Output and input: the front-back division 143 1.1 The nervous system 128 3.3 The major lobes: visible and hidden 145 1.2 The geography of the brain 129 3.4 The massive interconnectivity of the cortex and thalamus 149 2.0 Growing a brain from the bottom up 133 3.5 The satellites of the subcortex 151 2.1 Evolution and personal history are expressed in the brain 133 4.0 Summary 153 2.2 Building a brain from bottom to top 134 5.0 Chapter review 153 3.0 From ‘ where ’ to ‘ what ’ : the functional 5.1 Study questions 153 roles of brain regions 136 5.2 Drawing exercises 153 3.1 The cerebral hemispheres: the left-right division 136 1.0 INTRODUCTION found. -
The Human Brain Hemisphere Controls the Left Side of the Body and the Left What Makes the Human Brain Unique Is Its Size
About the brain Cerebrum (also known as the The brain is made up of around 100 billion nerve cells - each one cerebral cortex or forebrain) is connected to another 10,000. This means that, in total, we The cerebrum is the largest part of the brain. It is split in to two have around 1,000 trillion connections in our brains. (This would ‘halves’ of roughly equal size called hemispheres. The two be written as 1,000,000,000,000,000). These are ultimately hemispheres, the left and right, are joined together by a bundle responsible for who we are. Our brains control the decisions we of nerve fibres called the corpus callosum. The right make, the way we learn, move, and how we feel. The human brain hemisphere controls the left side of the body and the left What makes the human brain unique is its size. Our brains have a hemisphere controls the right side of the body. The cerebrum is larger cerebral cortex, or cerebrum, relative to the rest of the The human brain is the centre of our nervous further divided in to four lobes: frontal, parietal, occipital, and brain than any other animal. (See the Cerebrum section of this temporal, which have different functions. system. It is the most complex organ in our fact sheet for further information.) This enables us to have abilities The frontal lobe body and is responsible for everything we do - such as complex language, problem-solving and self-control. The frontal lobe is located at the front of the brain. -
Function of Cerebral Cortex
FUNCTION OF CEREBRAL CORTEX Course: Neuropsychology CC-6 (M.A PSYCHOLOGY SEM II); Unit I By Dr. Priyanka Kumari Assistant Professor Institute of Psychological Research and Service Patna University Contact No.7654991023; E-mail- [email protected] The cerebral cortex—the thin outer covering of the brain-is the part of the brain responsible for our ability to reason, plan, remember, and imagine. Cerebral Cortex accounts for our impressive capacity to process and transform information. The cerebral cortex is only about one-eighth of an inch thick, but it contains billions of neurons, each connected to thousands of others. The predominance of cell bodies gives the cortex a brownish gray colour. Because of its appearance, the cortex is often referred to as gray matter. Beneath the cortex are myelin-sheathed axons connecting the neurons of the cortex with those of other parts of the brain. The large concentrations of myelin make this tissue look whitish and opaque, and hence it is often referred to as white matter. The cortex is divided into two nearly symmetrical halves, the cerebral hemispheres . Thus, many of the structures of the cerebral cortex appear in both the left and right cerebral hemispheres. The two hemispheres appear to be somewhat specialized in the functions they perform. The cerebral hemispheres are folded into many ridges and grooves, which greatly increase their surface area. Each hemisphere is usually described, on the basis of the largest of these grooves or fissures, as being divided into four distinct regions or lobes. The four lobes are: • Frontal, • Parietal, • Occipital, and • Temporal. -
Translingual Neural Stimulation with the Portable Neuromodulation
Translingual Neural Stimulation With the Portable Neuromodulation Stimulator (PoNS®) Induces Structural Changes Leading to Functional Recovery In Patients With Mild-To-Moderate Traumatic Brain Injury Authors: Jiancheng Hou,1 Arman Kulkarni,2 Neelima Tellapragada,1 Veena Nair,1 Yuri Danilov,3 Kurt Kaczmarek,3 Beth Meyerand,2 Mitchell Tyler,2,3 *Vivek Prabhakaran1 1. Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA 2. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA 3. Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, USA *Correspondence to [email protected] Disclosure: Dr Tyler, Dr Danilov, and Dr Kaczmarek are co-founders of Advanced Neurorehabilitation, LLC, which holds the intellectual property rights to the PoNS® technology. Dr Tyler is a board member of NeuroHabilitation Corporation, a wholly- owned subsidiary of Helius Medical Technologies, and owns stock in the corporation. The other authors have declared no conflicts of interest. Acknowledgements: Professional medical writing and editorial assistance were provided by Kelly M. Fahrbach, Ashfield Healthcare Communications, part of UDG Healthcare plc, funded by Helius Medical Technologies. Dr Tyler, Dr Kaczmarek, Dr Danilov, Dr Hou, and Dr Prabhakaran were being supported by NHC-TBI-PoNS-RT001. Dr Hou, Dr Kulkarni, Dr Nair, Dr Tellapragada, and Dr Prabhakaran were being supported by R01AI138647. Dr Hou and Dr Prabhakaran were being supported by P01AI132132, R01NS105646. Dr Kulkarni was being supported by the Clinical & Translational Science Award programme of the National Center for Research Resources, NCATS grant 1UL1RR025011. Dr Meyerand, Dr Prabhakaran, Dr Nair was being supported by U01NS093650. -
Diverging Patterns of Atrophy and Hypometabolism in Syndromic
Simultaneous PET-MRI studies of the concordance of atrophy and hypometabolism in syndromic variants of Alzheimer’s disease and frontotemporal dementia: an extended case series *Kuven K Moodley1, *Daniela Perani2, Ludovico Minati1,3, Pasquale Anthony Della Rosa4, Frank Pennycook5, John C Dickson6, Anna Barnes6, Valeria Elisa Contarino7, Sofia Michopoulou7, Ludovico D’Incerti7, Catriona Good8, Federico Fallanca2, Emilia Giovanna Vanoli2, Peter J Ell6, and Dennis Chan1 *These authors equally contributed to the work 1Brighton and Sussex Medical School, Falmer, UK 2 Vita-Salute San Raffaele University, Nuclear Medicine Unit San Raffaele Hospital, Division of Neuroscience IRCCS San Raffaele, Milano, Italy 3Scientific Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy 4Institute of Molecular Bio-imaging and Physiology, National Research Council, Milano, Italy 5Open University, Milton Keynes, UK 6Institute of Nuclear Medicine, University College London, London, UK 7Neuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy 8Hurstwood Park Neurosciences Centre, West Sussex, UK Corresponding Author: Dr Dennis Chan Herchel Smith Building for Brain and Mind Sciences Department of Clinical Neurosciences University of Cambridge Forvie Site, Robinson Way Cambridge CB2 0SZ Email: [email protected] Word count Abstract 278 Main Text 4969 Tables 1 Figures 6 Supplementary Figures 6 1 Abstract Aims. The primary objective was to determine the concordance of brain atrophy and hypometabolism in six syndromic variants of Alzheimer’s disease (AD) and frontotemporal dementia spectrum (FTD). A second objective was to determine the effect of image analysis methods on identification of atrophy and hypometabolism by comparing the changes observed through qualitative rating with those detected by quantitative methods. -
Body Awareness Disorders: Dissociations Between Body-Related Visual and Somatosensory Information Laure Pisella, Laurence Havé, Yves Rossetti
Body awareness disorders: dissociations between body-related visual and somatosensory information Laure Pisella, Laurence Havé, Yves Rossetti To cite this version: Laure Pisella, Laurence Havé, Yves Rossetti. Body awareness disorders: dissociations between body- related visual and somatosensory information. Brain - A Journal of Neurology , Oxford University Press (OUP), 2019, 142 (8), pp.2170-2173. 10.1093/brain/awz187. hal-02346581 HAL Id: hal-02346581 https://hal.archives-ouvertes.fr/hal-02346581 Submitted on 7 Nov 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. BADs: dissociations between body-related visual and somatosensory information L. Pisella1, L. Havé1,3 & Y. Rossetti1,2 1 ImpAct Team, Lyon Neuroscience Research Center CRNL, INSERM U1028, CNRS UMR5292 and University Claude Bernard Lyon I, Villeurbanne, France 2 Plate-forme Mouvement et Handicap, Hospices Civils de Lyon, Centre de Recherche en Neurosciences de Lyon, 69500 Bron, France 3 Hôpital d'instruction des armées Desgenettes, 69275 Lyon, France Glossary : Precuneus: medial part of the posterior parietal cortex, between the occipital (cuneus) and the anterior parietal (paracentral lobule) cortices, well located for visual- somatosensory integration. Body image typically depicts mental representation of one’s own body, arising from all sources of sensory and cognitive information, whereas body schema is used to depict the unconscious use of sensory information required by our motor system to maintain body posture and produce accurate movements.