PowerPoint® Lecture Slides

Prepared by Patty Bostwick-Taylor, Florence-Darlington Technical College

C H A P T E R 11

The Cardiovascular System

© 2012 Pearson Education, Inc. Blood Vessels: The Vascular System • Transport blood to the tissues and back

• Carry blood from the heart • • Arterioles

• between tissues and blood • Capillary beds

• Return blood the heart • Venules •

© 2012 Pearson Education, Inc. (a) © 2012 Pearson Education, Inc. Figure 11.10a Blood Vessels: Microscopic Anatomy

• Three layers (tunics) • Tunic • Endothelium

• Tunic • Smooth muscle • Controlled by sympathetic nervous system

• Tunic • Mostly fibrous connective tissue

© 2012 Pearson Education, Inc. Structural Differences Among Blood Vessels

• Arteries have a thicker tunica media than veins

• Capillaries are only one cell layer (tunica intima) to allow for exchanges between blood and tissue

• Veins have a thinner tunica media than arteries • Veins also have valves to prevent backflow of blood • Lumen of veins are larger than arteries

© 2012 Pearson Education, Inc. Valve Tunica intima • Endothelium • Loose connective tissue Internal elastic lamina Tunica media • Smooth muscle • Elastic fibers External elastic lamina Tunica externa • Collagen fibers

Lumen Venule Lumen Artery Arteriole Vein Capillary network

Basement membrane Endothelial cells

(b) Capillary © 2012 Pearson Education, Inc. Figure 11.10b Movement of Blood Through Vessels

•Most arterial blood is pumped by the heart

•Veins use the milking action of muscles to help move blood

© 2012 Pearson Education, Inc. Valve (open)

Contracted skeletal muscle

Valve (closed)

Vein

Direction of blood flow

© 2012 Pearson Education, Inc. Figure 11.11 Capillary Beds

•Capillary beds consist of two types of vessels

• —vessel directly connecting an arteriole to a venule

• —exchange vessels • Oxygen and nutrients cross to cells • Carbon dioxide and metabolic waste products cross into blood

© 2012 Pearson Education, Inc. Vascular shunt Precapillary sphincters

True capillaries Terminal arteriole Postcapillary venule (a) Sphincters open; blood flows through true capillaries. © 2012 Pearson Education, Inc. Figure 11.12a © 2012 Pearson Education, Inc. Figure 11.12b Major Arteries of System Circulation

• Largest artery in the body • Leaves from the left ventricle of the heart

• Regions • Ascending aorta—leaves the left ventricle • Aortic arch—arches to the left • Thoracic aorta—travels downward through the thorax • Abdominal aorta—passes through the diaphragm into the abdominopelvic cavity

© 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Major Arteries of System Circulation

•Arterial branches of the ascending aorta •Right and left coronary arteries serve the heart

© 2012 Pearson Education, Inc. Brachiocephalic trunk Left common carotid artery Superior vena cava Left subclavian artery Right pulmonary artery Aortic arch Ligamentum arteriosum Ascending aorta Left pulmonary artery Pulmonary trunk Left pulmonary veins

Right pulmonary Left atrium veins Auricle of left atrium Right atrium Circumflex artery Right coronary artery in coronary sulcus (right Left coronary artery in atrioventricular groove) coronary sulcus (left atrioventricular groove) Anterior cardiac vein Left ventricle Right ventricle Great cardiac vein Marginal artery Anterior interventricular Small cardiac vein artery (in anterior interventricular sulcus) Inferior vena cava Apex (a)

© 2012 Pearson Education, Inc. Figure 11.3a Major Arteries of Systemic Circulation • Arterial branches of the aortia arch (BCS)

• Brachiocephalic trunk splits into the • Right common carotid artery • Right subclavian artery

• Left common carotid artery splits into the • Left internal and external carotid arteries

• Left subclavian artery branches into the • Vertebral artery • In the axilla, the subclavian artery becomes the axillary artery  brachial artery  radial and ulnar arteries © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Major Arteries of Systemic Circulation

•Arterial branches of the thoracic aorta •Intercostal arteries supply the muscles of the thorax wall

•Other branches of the thoracic aorta supply the •Lungs (bronchial arteries) •Esophagus (esophageal arteries) •Diaphragm (phrenic arteries)

© 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Major Arteries of Systemic Circulation

• Arterial branches of the abdominal aorta • Celiac trunk is the first branch of the abdominal aorta. Three branches are • Left gastric artery (stomach) • Splenic artery (spleen) • Common hepatic artery (liver)

• Superior mesenteric artery supplies most of the small intestine and first half of the large intestine

© 2012 Pearson Education, Inc. Major Arteries of Systemic Circulation

• Arterial branches of the abdominal aorta • Left and right renal arteries (kidney)

• Left and right gonadal arteries • Ovarian arteries in females serve the ovaries • Testicular arteries in males serve the testes

• Lumbar arteries serve muscles of the and trunk

© 2012 Pearson Education, Inc. Major Arteries of Systemic Circulation

• Arterial branches of the abdominal aorta • Inferior mesenteric artery serves the second half of the large intestine

• Left and right common iliac arteries are the final branches of the aorta • Internal iliac arteries serve the pelvic organs • External iliac arteries enter the thigh  femoral artery  popliteal artery  anterior and posterior tibial arteries

© 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Arteries of the head and trunk Internal carotid artery External carotid artery Common carotid arteries Vertebral artery Arteries that supply the upper limb Subclavian artery Subclavian artery Brachiocephalic trunk Aortic arch Axillary artery Ascending aorta Coronary artery Thoracic aorta (above diaphragm) Brachial artery Celiac trunk Abdominal aorta Superior mesenteric Radial artery artery Ulnar artery Renal artery Gonadal artery Deep palmar arch

Superficial palmar arch Digital arteries

Inferior mesenteric artery Arteries that supply the lower limb Common iliac artery External iliac artery Femoral artery Popliteal artery

Anterior tibial artery Posterior tibial artery

Dorsalis pedis artery

Arcuate artery

© 2012 Pearson Education, Inc. Figure 11.13 Major Veins of Systemic Circulation

•Superior and inferior vena cava enter the right atrium of the heart

•Superior vena cava drains the head and arms

•Inferior vena cava drains the lower body

© 2012 Pearson Education, Inc. Superior vena cava Aorta

Left pulmonary artery Right pulmonary artery Left atrium

Right atrium Left pulmonary veins Right pulmonary veins Pulmonary semilunar valve Left atrioventricular valve Fossa ovalis (bicuspid valve) Aortic semilunar valve Right atrioventricular valve (tricuspid valve) Left ventricle Right ventricle

Chordae tendineae Interventricular septum Inferior vena cava Myocardium

Visceral pericardium

(b) Frontal section showing interior chambers and valves.

© 2012 Pearson Education, Inc. Figure 11.3b Major Veins of Systemic Circulation • Veins draining into the superior vena cava

• Radial and ulnar veins  brachial vein  axillary vein

• These veins drain the arms

• Cephalic vein drains the lateral aspect of the arm and empties into the axillary vein

• Basilic vein drains the medial aspect of the arm and empties into the brachial vein

• Basilic and cephalic veins are jointed at the median cubital © 2012 Pearsonvein Education, (elbow Inc. area) Major Veins of Systemic Circulation

• Veins draining into the superior vena cava

• Subclavian vein receives • Venous blood from the arm via the axillary vein

• Venous blood from skin and muscles via external jugular vein

• Vertebral vein drains the posterior part of the head

• Internal jugular vein drains the dural sinuses of the brain

© 2012 Pearson Education, Inc. Major Veins of Systemic Circulation

• Veins draining into the superior vena cava

• Left and right brachiocephalic veins receive venous blood from the • Subclavian veins • Vertebral veins • Internal jugular veins

• Brachiocephalic veins join to form the superior vena cava  right atrium of heart

• Azygous vein drains the thorax

© 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Major Veins of Systemic Circulation • Veins draining into the inferior vena cava

• Anterior and posterior tibial veins and fibial veins drain the legs

• Posterior tibial vein  popliteal vein   external

• Great saphenous veins (longest veins of the body) receive superficial drainage of the legs

• Each (left and right) is formed by the union of the internal and external iliac vein on its

© 2012 Pearson ownEducation, sideInc. Major Veins of Systemic Circulation

• Veins draining into the inferior vena cava

• Right drains the right ovary in females and right testicle in males

• Left gonadal vein empties into the left

• Left and right renal veins drain the kidneys

• Hepatic portal vein drains the digestive organs and travels through the liver before it enters systemic circulation

© 2012 Pearson Education, Inc. Major Veins of Systemic Circulation

•Veins draining into the inferior vena cava

•Left and right hepatic veins drain the liver

© 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Veins of the head and trunk Dural venous sinuses

External jugular vein Vertebral vein Internal jugular vein Veins that drain the upper limb Right and left Subclavian vein brachiocephalic veins Axillary vein Superior vena cava Cephalic vein Brachial vein Great cardiac vein Basilic vein

Hepatic veins Splenic vein Hepatic portal vein Renal vein Median cubital vein Superior Ulnar vein mesenteric vein Radial vein Inferior mesenteric vein Digital veins

Veins that drain the lower limb External iliac vein Inferior vena cava Femoral vein Common iliac vein Great saphenous vein Popliteal vein Posterior tibial vein Anterior tibial vein Small saphenous vein

Dorsal venous arch Dorsal metatarsal veins

© 2012 Pearson Education, Inc. Figure 11.14 Arterial Supply of the Brain

• Internal carotid arteries divide into • Anterior and middle cerebral arteries • These arteries supply most of the cerebrum

• Vertebral arteries join once within the skull to form the basilar artery • Basilar artery serves the brain stem and cerebellum

© 2012 Pearson Education, Inc. Arterial Supply of the Brain

•Posterior cerebral arteries form from the division of the basilar artery

•These arteries supply the posterior cerebrum

© 2012 Pearson Education, Inc. Circle of Willis

• Anterior and posterior blood supplies are united by small communicating arterial branches

• Result—complete circle of connecting blood vessels called cerebral arterial circle or circle of Willis

© 2012 Pearson Education, Inc. Anterior Cerebral arterial circle Frontal lobe (circle of Willis) Optic chiasma • Anterior communicating Middle artery cerebral artery • Anterior cerebral artery Internal • Posterior carotid communicating artery artery Mammillary • Posterior body cerebral artery Temporal Basilar artery lobe Vertebral artery Pons Occipital lobe Cerebellum

(a) Posterior © 2012 Pearson Education, Inc. Figure 11.15a © 2012 Pearson Education, Inc. Figure 11.15b Fetal Circulation

• Fetus receives exchanges of gases, nutrients, and wastes through the placenta

• Umbilical cord contains three vessels • —carries blood rich in nutrients and oxygen to the fetus

• Umbilical arteries (2)—carry carbon dioxide and debris-laden blood from fetus to placenta

© 2012 Pearson Education, Inc. Superior vena cava Ductus arteriosus Pulmonary artery Pulmonary veins Foramen ovale

Inferior vena cava Hepatic vein Inferior vena cava Hepatic portal vein

Umbilical vein Fetal umbilicus Aorta Common iliac artery Umbilical cord External iliac artery Internal iliac artery Umbilical arteries Urinary bladder

KEY: High oxygenation Moderate oxygenation Low oxygenation Very low oxygenation Placenta

© 2012 Pearson Education, Inc. Figure 11.16 Fetal Circulation

• Blood flow bypasses the liver through the and enters the inferior vena cava  right atrium of heart

• Blood flow bypasses the lungs • Blood entering right atrium is shunted directly into the left atrium through the

• connects the aorta and pulmonary trunk (becomes arteriosum at birth)

© 2012 Pearson Education, Inc. Brachiocephalic trunk Left common carotid artery Superior vena cava Left subclavian artery Right pulmonary artery Aortic arch Ligamentum arteriosum Ascending aorta Left pulmonary artery Pulmonary trunk Left pulmonary veins

Right pulmonary Left atrium veins Auricle of left atrium Right atrium Circumflex artery Right coronary artery in coronary sulcus (right Left coronary artery in atrioventricular groove) coronary sulcus (left atrioventricular groove) Anterior cardiac vein Left ventricle Right ventricle Great cardiac vein Marginal artery Anterior interventricular Small cardiac vein artery (in anterior interventricular sulcus) Inferior vena cava Apex (a)

© 2012 Pearson Education, Inc. Figure 11.3a Superior vena cava Aorta

Left pulmonary artery Right pulmonary artery Left atrium

Right atrium Left pulmonary veins Right pulmonary veins Pulmonary semilunar valve Left atrioventricular valve Fossa ovalis (bicuspid valve) Aortic semilunar valve Right atrioventricular valve (tricuspid valve) Left ventricle Right ventricle

Chordae tendineae Interventricular septum Inferior vena cava Myocardium

Visceral pericardium

(b) Frontal section showing interior chambers and valves.

© 2012 Pearson Education, Inc. Figure 11.3b Hepatic Portal Circulation

• Veins of hepatic portal circulation drain • Digestive organs • Spleen • Pancreas

• Hepatic portal vein carries this blood to the liver

• Liver helps maintain proper glucose, fat, and protein concentrations in blood

© 2012 Pearson Education, Inc. Hepatic Portal Circulation

•Major vessels of hepatic portal circulation

•Inferior and superior mesenteric veins

•Splenic vein

•Left gastric vein

© 2012 Pearson Education, Inc. Arterial Venous blood blood Inferior vena cava Stomach and intestine Liver Nutrients and Liver cells (hepatocytes) toxins absorbed Nutrients and toxins leave

Hepatic portal vein

First capillary bed Second capillary bed (liver sinusoids) Hepatic vein

Hepatic portal system

© 2012 Pearson Education, Inc. Figure 11.17 Inferior vena cava (not part of )

Gastric veins Liver Spleen Stomach Hepatic portal vein Splenic vein

Inferior mesenteric vein

Superior mesenteric vein

Small intestine Large intestine

© 2012 Pearson Education, Inc. Figure 11.18