The Association of Serotonin Receptor 3A Methylation with Maternal
G Model BBR-10497; No. of Pages 10 ARTICLE IN PRESS Behavioural Brain Research xxx (2016) xxx–xxx Contents lists available at ScienceDirect Behavioural Brain Research journal homepage: www.elsevier.com/locate/bbr Research report The association of serotonin receptor 3A methylation with maternal ଝ violence exposure, neural activity, and child aggression a,∗ a,b a c Daniel S. Schechter , Dominik A. Moser , Virginie C. Pointet , Tatjana Aue , e d e a Ludwig Stenz , Ariane Paoloni-Giacobino , Wafae Adouan , Aurélia Manini , a a a f Francesca Suardi , Marylene Vital , Ana Sancho Rossignol , Maria I. Cordero , a a a e,g Molly Rothenberg , Franc¸ ois Ansermet , Sandra Rusconi Serpa , Alexandre G. Dayer a Division of Child & Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland b Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States c Institute of Psychology, University of Bern, Bern, Switzerland d Department of Genetic Medecine and Development, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland e Department of Mental Health and Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland f Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester, United Kingdom g Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland h i g h l i g h t s • Maternal severity of interpersonal violence exposure (IPV) was associated with diagnosis of maternal post-traumatic stress disorder (PTSD). • Maternal IPV-PTSD was in turn associated with disturbed child attachment. • HTR3A gene methylation was linked to maternal IPV exposure and aggressive behavior and disturbed child attachment and self-endangering behavior.
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