GREATNESS AWAITS Commemorative Agenda
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] ] [ News ] Analysis ] Commentary ] Controversy ] June 25, 2012 Vol. 34 No. 12 oncology-times.com Publishing for O34 Years NCOLOGY The Independent IMES Hem/Onc News Source T ASCO Annual Meeting! • Controlling Breakthrough Chemo-Induced Nausea & Vomiting • Needed: More MD Knowledge about Long-Term Effects of Cancer Drugs • Myeloma: Novel Agents + Standard Therapy for Bortezomib-Refractory Patients • CLL: Ibrutinib for Older Patients • GIST: New Third-Line Agent • Pediatric Cancer: Crizotinib Effective for ALK-Driven Tumors Coverage starts on page 8 Photos from the Annual Meeting: Todd Buchanan/ASCO2012 Todd Meeting: the Annual from Photos Hodgkin Lymphoma: ANNE TSAO: How I Treat Novel Agents as Bridge Changing Perceptions about Patients with Limited-Stage to Transplant for Selected Unnecessary Tests p.9 OT iPad App! Small Cell Lung Cancer p.20 Patients p.26 [ALSO] SHOP TALK �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �5 LETTERS� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �6 Crossover Trial Validates Accelerated Approval of Sunitinib for GIST � � � � � � � � � � � � � � � � � � � � � �19 Early Breast Cancer: HER2 Peptide Vaccine Helps Delay Recurrence � � � � � � � � � � � � � � � � � � � � � �24 GEORGE SLEDGE: ‘Perchance to Dream’ �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �28 POETRY BY CANCER CAREGIVERS: Amir Steinberg, MD �� � � � � � � � � � � � � � � � � � � � � -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
Knockout Mice and Test-Tube Babies
© 2001 Nature Publishing Group http://medicine.nature.com FOREWORD Laskers for 2001: Knockout mice and test-tube babies Compared with mathematics and physics, biology and medi- Oliver Smithies independently devised an ingenious method cine are mainly empirical sciences. As there are no grand uni- of homologous recombination that allows the preplanned fied theories to guide experiments, conceptual advances in and precise mutation of any desired gene among the ~35,000 the biomedical sciences are crucially dependent on techno- contained within the genome of ES cells. Combination of logical innovations. Examples of such innovations that have the Capecchi–Smithies technique of gene targeting with the revolutionized biology include recombinant DNA, DNA se- Evans technique of ES cell biology led to the first knockout quencing, polymerase chain reaction and monoclonal anti- mice in 1989, an exceptional advance that completely bodies. Examples of new technologies that have changed the style of contemporary biomedical science by revolutionized the practice of medicine include the making it possible to study the function of almost any single heart–lung machine and open heart surgery, coronary an- gene. So far, more than 4,000 of the ~35,000 mouse genes giography and coronary bypass have been knocked out, and more surgery, computer-assisted tomog- than 500 mouse models of human raphy and positron-emission to- disease have been created. mography, and immunosuppression Knockout mice are used today by and organ transplantation. thousands of scientists, both in This year’s Lasker Awards cele- academia and in the pharmaceuti- brate the development of two tech- cal/biotechnology industry. nologies that are comparable in The rise of the mouse to such ex- inventiveness and impact to those alted status in biomedical research mentioned above. -
Lasker Awards Honor Trailblazers in Medical Research and Public Service
EMBARGOED FOR RELEASE UNTIL SEPTEMBER 14, 2009 FROM: The Albert and Mary Lasker Foundation New York, New York CONTACT: Rubenstein Communications, Inc. Charles Zehren 212-843-8590 [email protected] Janet Wootten 212-843-8032 [email protected] 2009 LASKER AWARDS HONOR TRAILBLAZERS IN MEDICAL RESEARCH AND PUBLIC SERVICE: John Gurdon and Shinya Yamanaka, for Breakthrough Research in Nuclear Reprogramming and Stem Cells Brian J. Druker, Nicholas B. Lydon and Charles L. Sawyers, for Lifesaving Discoveries in Treatment of Leukemia Michael R. Bloomberg, for Landmark Policy and Philanthropic Initiatives to Reduce Tobacco Use and Foster Public Health New York, Sept. 13, 2009 - The Albert and Mary Lasker Foundation, which for 64 years has championed the greatest breakthroughs in medical research, today announced the winners of the 2009 Lasker Awards for outstanding accomplishments in basic medical and clinical medical research, and public service. The three awards—recognized as the most prestigious medical research awards in the United States today— honor six visionaries whose insight and courage has led to dramatic advances that will prevent disease and prolong life. John Gurdon of Cambridge University and Shinya Yamanaka of Kyoto University will receive the 2009 Albert Lasker Basic Medical Research Award for breakthrough discoveries into the process that instructs specialized adult cells to form stem cells. Brian J. Druker of Oregon Health & Science University, Nicholas B. Lydon, formerly of Novartis, and Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center will receive the 2009 Lasker~DeBakey Clinical Medical Research Award for groundbreaking work on the treatment of chronic myeloid leukemia. New York City Mayor Michael R. -
Graduate Students Bring Clinical Know- Throughout Their Dissertation Work
Disease Models & Mechanisms 2, 531-533 (2009) Published by The Company of Biologists 2009 COMMUNITY NEWS and a clinical mentor, most commonly one PhD and one MD, Graduate students bring clinical know- throughout their dissertation work. Students first choose a basic how into their lab work through the HHMI science mentor and laboratory, and outline the clinical and Med into Grad program translational potentials of their project. Next, students choose a clinical mentor, who plays an active role in shaping the student’s Ryan J. Hartmaier and Donald R. Shaffer project, meets regularly with the student and thesis committee, and helps to provide access to valuable patient samples. The The launch of the National Institutes of Health (NIH) roadmap in early marriage of a basic and clinical scientist on each student’s 2004 increased the biomedical community’s focus on advisory team sets the stage for fruitful collaborations and a truly translational research by designating significant funding for translational experience. discoveries in basic research that could lead to changes in patient Some of the best learning opportunities take place through care. Scientists who once lived at the bench are increasingly informal coffee shop meetings where a student discusses, with asked to support the clinical significance of their work. To both mentors, the details and direction of a project that will demonstrate their bench-to-bedside applicability, researchers simultaneously address a basic research question and have now feel encouraged to include patient sample analysis to diagnostic or therapeutic potential. The program puts graduate complement a mechanistic study or in vitro mechanistic data to students at the interface between basic science and the clinic, support a population study. -
Award Winning Research Kyoto University Is Acknowledged As One of the Most Accomplished Research-Oriented Universities in Asia
Award Winning Research Kyoto University is acknowledged as one of the most accomplished research-oriented universities in Asia. That reputation is 2016 testified by the accolades conferred on our alumni and researchers, most notably nine Nobel Prize laureates who undertook vital research during their time at the university. In addition to those awards, several other Kyoto University faculty members have received major accolades, including two Fields Medalists, one Gauss Prize winner, and five Lasker Award winners. Nobel Prize 1949, Physics 1965, Physics 1981, Chemistry 1987, Physiology and 2001, Chemistry Hideki Yukawa Shinichiro Tomonaga Kenichi Fukui Medicine Ryoji Noyori Susumu Tonegawa 2008, Physics 2008, Physics 2012, Physiology or 2014, Physics Makoto Kobayashi Toshihide Maskawa Medicine Isamu Akasaki Shinya Yamanaka Fields Medal Gauss Prize Kyoto Prize 1970, Mathematics 1990, Mathematics 2006, Mathematics 1995, Basic Sciences 1998, Basic Sciences 2004, 2010, Heisuke Hironaka Shigefumi Mori Kiyoshi Ito Chushiro Hayashi Kiyoshi Ito Advanced Technology Advanced Technology Alan Curtis Kay Shinya Yamanaka Japan Prize Lasker Award 2005, Information and 2005, Cell Biology 1987, Basic Medical 1989, Basic Medical 1998, Basic Medical 2009, Basic Medical 2014, Basic Medical Media Technology Masatoshi Takeichi Research Research Research Research Research Makoto Nagao Susumu Tonegawa Yasutomi Nishizuka Yoshio Masui Shinya Yamanaka Kazutoshi Mori *photos provided by the Japan Prize Foundation ©e Nobel Foundation2012 photo by Alexander Mahmoud Dr. Shinya Yamanaka, director of the Prof. Kayo Inaba, Kyoto University’s Prof. Kazutoshi Mori of Kyoto Center for iPS Cell Research and executive vice-president for gender University’s Graduate School of Science Application (CiRA), receives the 2012 equality, international affairs, and public receiving the 2014 Albert Lasker Award Nobel Prize in Physiology or Medicine. -
Las Vegas, Nevada
TIM TO THRIVE PROMOTING SAFETY, INCLUSION AND WELL-BEING FOR LGBTQ YOUTH…EVERYWHERE! FEBRUARY 14 – 16, 2014 LAS VEGAS, NEVADA PRESENTING SPONSOR: CO-PRESENTING CONFERENCE PARTNERS: BALLY’S LAS VEGAS 26TH FLOOR BALLY’S EVENT CENTER • Plenaries • Conference Meals Office • Exhibitors CONFERENCE Skyview 4 REGISTRATION Skyview 3 Conference Room Skyview 2 omenade r Bally’s P Catering & w e Convention i v Sales y Skyview 1 k S PALACE MEETING ROOMS J Elevators ELEVATORS TO WORKSHOPS HELD IN Drai's Skyview SKYVIEW ROOMS 1-6 Foyer Les (GO TO FLOOR 26) Elements Signatures Gift Shop Burger Brasserie The Strip Digital Skyview 5 World Skyview 6 CASINO LEVEL ELEVATORS TO WORKSHOPS HELD IN LAS VEGAS 1-7 (GO TO FLOOR 3) 1 2 3 4 5 6 7 Lobby Offices LAS VEGAS BALLROOM s r Convention o Service Office at v e l E THIRD FLOOR WELCOME Thank you for attending the Human Rights Campaign Foundation’s inaugural national conference, Time to THRIVE, co-presented by the National Education Association and the American Counseling Association. We have three exciting and empowering days planned to help you promote safety, inclusion and well-being for LGBTQ youth in your community. This conference would not be possible without support from our sponsors, including a generous presenting sponsorship from AT&T. This weekend you will hear from amazing speakers, special guests and expert presenters in dozens of workshops. Our goal in all of this is to give you answers and resources that help you do important work in your own communities. In my work with the Human Rights Campaign Foundation and as a former educator, I know first-hand that being a change agent takes courage and intentionality. -
Lasker Interactive Research Nom'18.Indd
THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will -
A Challenge a Most- Deserved Honour
VOL 6 NO 3 AUTUMN 2007 Promoting Cardiovascular Education, Research and Patient Care In This Issue A Challenge 37 A Challenge Over the past 10 years, the A Most- 37 A Most-Deserved Honour Academy has built a base Deserved 38 Executive Committe for international connectiv- ity for promoting cardiovas- 40 Reports from Japan Meeting Honour cular health. This has been 41 Doctor Receives Volvos for Life “HOUSTON -- (October 2, 2007) achieved by establishing Legislation authorizing a Congres- 42 XVII Brazil Forum seven sections and hold- sional Gold Medal for Dr. Michael 43 Lasker Award for Development ing a variety of workshops, E. DeBakey, pioneering heart sur- of Prosthetic Heart Valves symposia and conferences geon and chancellor emeritus of 44 Indian First-in-man Trials all over the world as well as Baylor College of Medicine, is on 47 Turkey Symposium having several publications its way to President George W. and its own website. 48 John Madden’s “Coach’s Corner” Bush for his signature. Currently, the Academy is proposing to promote link- 49 Mendel Symposium II The U.S. Congress today ap- ages among cardiovascular institutes and centres in proved the bill that now will be 50 Dr. William Parmley the area of population health, clinical studies, scientific forwarded to the president. U.S. 50 Dr. Bohdan Lewartowski investigations, prevention and education for improving Senator Kay Bailey Hutchison and 51 Dr. Sergio Dalla-Volta cardiovascular health. This could help facilitate exchang- U.S. Reps. Al Green, Michael Bur- 52 Dr. Garrett Gross es of health professionals and foster collaborations. -
Distinguished World Leaders in Science and Technology Mentoring
Distinguished World Leaders in Aneesh Chopra Sylvester James Gates, Jr., Ph.D. Chief Technology Officer of the United States, 2009-2012 Recipient, National Medal of Science for Physical Science Science and Technology Mentoring Aneesh Chopra is a groundbreaking member of the technology Dr. Gates is one of America’s most renowned theoretical physicists. field. Appointed by President Barack Obama, he served as the first In 2013, he was elected to the National Academy of Sciences Chief Technology Officer of the United States. During his time in and became the first African-American physicist so recognized office, Aneesh designed the National Wireless Initiative, helped in its 150- year history. He is especially known for his work on Delegates Have Included... launch Startup America, and executed an “open innovation” strategy supersymmetry, supergravity, and superstring theory. Dr. Gates is currently a across the government. He is the author of the book, “Innovative State: How New Professor of Physics at Brown University; the Director of the String and Particle Technologies Can Transform Government.” Theory Center, and Affiliate Professor of Mathematics. He serves on the U.S. J. Craig Venter, Ph.D. President’s Council of Advisers on Science and Technology, on the National Commission on Forensic Science, and on the Maryland State Board of Education. — THE GRANDg MASTERS — Decoded the Human Genome Recipient, 2009 Presidential National Medal of Science Dean Kamen Dr. Venter is regarded as one of the leading scientists of the 21st Recipient, National Medal of Technology and Innovation John C. Mather, Ph.D. Legendary Inventor Academy Science Director century for his numerous contributions to genomic research. -
Lasker Foundation 2019 Annual Report
Annual ALBERT AND MARY Report L ASKER FOUNDATION 2019 Annual Report 2019 1 LETTER FROM THE PRESIDENT & CHAIR OUR MISSION To improve health by accelerating support for medical research through recognition of research excellence, Communicating advocacy, and education. the Importance of Supporting Medical Research The Lasker Foundation celebrates the power of medical research, from fundamental science to initiatives expanding access to clinical advances. This year’s awards — serendipitously, all in the field of immunology — highlight this range. Max D. Cooper and Jacques Miller received the Albert Lasker Basic Medical Research Award for delineating the organizing principle of the adaptive immune system and launching the course of modern immunology. H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich were awarded the Lasker~DeBakey Clinical Medical Research Award for their invention of Herceptin® (trastuzumab), the first monoclonal antibody that blocks a cancer- causing protein, and for its development as a life-saving cancer therapy. The Lasker~Bloomberg Public Service Award was given to Gavi, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of vaccination to prevent disease. By shining a light on important advances, the Lasker Awards help us communicate to an international audience how scientific breakthroughs benefit us all. To accelerate support for science, we must ensure our message reaches all constituencies, including the public, scientists, policymakers, and donors. Lasker’s partnerships and programs also help achieve this goal. For example, our annual Public Lecture series connects accomplished scientists to the public to promote the understanding and the promise of biomedical science. -
Standup Walker of the Year NOMINATE YOUR RISING STAR in the HOME HEALTHCARE INDUSTRY FAVORITE INNOVATOR
DIGEST InventorsAPRIL 2016 Volume 32 Issue 4 DIGEST IPOEF Inventor StandUp Walker of the Year NOMINATE YOUR RISING STAR IN THE HOME HEALTHCARE INDUSTRY FAVORITE INNOVATOR Jack Andraka DISCOVERS A DEVICE TO DETECT PANCREATIC CANCER Total Tie Keep NO MORE BLOWIN’ IN THE WIND 3D Printers ARE THEY WORTH THE INVESTMENT? Almost Perfect PROFITING FROM YOUR INVENTION The Business of Inventing DO YOU HAVE WHAT IT TAKES? $3.95 FULTON, MO FULTON, PERMIT 38 PERMIT US POSTAGE PAID POSTAGE US PRSRT STANDARD PRSRT EDITOR’S NOTE InventorsDIGEST The Next EDITOR-IN-CHIEF BIG Thing CAMA MCNAMARA This month’s cover story should be of interest to ART DIRECTOR inventors looking for the next big thing. While CARRIE BOYD over the past decade numerous products have been developed for tech-savvy, time-conscious CONTRIBUTORS millenials, at the opposite end of the spectrum STEPHEN BRACHMANN are aging baby boomers, who are creating INNOVATOR INSIGHTS multiple marketing opportunities. As their numbers continue to increase, so JACK LANDER does the potential for product development. JEREMY LOSAW Ken Paulus’ company, URise Products, is on the cutting-edge of what has GENE QUINN been coined the “silver tsunami.” According to the Pew Research Center, 10,000 JOHN RAU boomers will turn 65 today, and 10,000 more will turn 65 every day for the next 19 EDIE TOLCHIN years. That’s a lot of knees and hips in need of repair. It’s also an enormous number LAWRENCE J. UDELL of people searching for ways to maintain their health, mobility, independence and quality of life, which is of concern to Paulus and his company.