A Challenge a Most- Deserved Honour
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
Knockout Mice and Test-Tube Babies
© 2001 Nature Publishing Group http://medicine.nature.com FOREWORD Laskers for 2001: Knockout mice and test-tube babies Compared with mathematics and physics, biology and medi- Oliver Smithies independently devised an ingenious method cine are mainly empirical sciences. As there are no grand uni- of homologous recombination that allows the preplanned fied theories to guide experiments, conceptual advances in and precise mutation of any desired gene among the ~35,000 the biomedical sciences are crucially dependent on techno- contained within the genome of ES cells. Combination of logical innovations. Examples of such innovations that have the Capecchi–Smithies technique of gene targeting with the revolutionized biology include recombinant DNA, DNA se- Evans technique of ES cell biology led to the first knockout quencing, polymerase chain reaction and monoclonal anti- mice in 1989, an exceptional advance that completely bodies. Examples of new technologies that have changed the style of contemporary biomedical science by revolutionized the practice of medicine include the making it possible to study the function of almost any single heart–lung machine and open heart surgery, coronary an- gene. So far, more than 4,000 of the ~35,000 mouse genes giography and coronary bypass have been knocked out, and more surgery, computer-assisted tomog- than 500 mouse models of human raphy and positron-emission to- disease have been created. mography, and immunosuppression Knockout mice are used today by and organ transplantation. thousands of scientists, both in This year’s Lasker Awards cele- academia and in the pharmaceuti- brate the development of two tech- cal/biotechnology industry. nologies that are comparable in The rise of the mouse to such ex- inventiveness and impact to those alted status in biomedical research mentioned above. -
Lasker Awards Honor Trailblazers in Medical Research and Public Service
EMBARGOED FOR RELEASE UNTIL SEPTEMBER 14, 2009 FROM: The Albert and Mary Lasker Foundation New York, New York CONTACT: Rubenstein Communications, Inc. Charles Zehren 212-843-8590 [email protected] Janet Wootten 212-843-8032 [email protected] 2009 LASKER AWARDS HONOR TRAILBLAZERS IN MEDICAL RESEARCH AND PUBLIC SERVICE: John Gurdon and Shinya Yamanaka, for Breakthrough Research in Nuclear Reprogramming and Stem Cells Brian J. Druker, Nicholas B. Lydon and Charles L. Sawyers, for Lifesaving Discoveries in Treatment of Leukemia Michael R. Bloomberg, for Landmark Policy and Philanthropic Initiatives to Reduce Tobacco Use and Foster Public Health New York, Sept. 13, 2009 - The Albert and Mary Lasker Foundation, which for 64 years has championed the greatest breakthroughs in medical research, today announced the winners of the 2009 Lasker Awards for outstanding accomplishments in basic medical and clinical medical research, and public service. The three awards—recognized as the most prestigious medical research awards in the United States today— honor six visionaries whose insight and courage has led to dramatic advances that will prevent disease and prolong life. John Gurdon of Cambridge University and Shinya Yamanaka of Kyoto University will receive the 2009 Albert Lasker Basic Medical Research Award for breakthrough discoveries into the process that instructs specialized adult cells to form stem cells. Brian J. Druker of Oregon Health & Science University, Nicholas B. Lydon, formerly of Novartis, and Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center will receive the 2009 Lasker~DeBakey Clinical Medical Research Award for groundbreaking work on the treatment of chronic myeloid leukemia. New York City Mayor Michael R. -
Graduate Students Bring Clinical Know- Throughout Their Dissertation Work
Disease Models & Mechanisms 2, 531-533 (2009) Published by The Company of Biologists 2009 COMMUNITY NEWS and a clinical mentor, most commonly one PhD and one MD, Graduate students bring clinical know- throughout their dissertation work. Students first choose a basic how into their lab work through the HHMI science mentor and laboratory, and outline the clinical and Med into Grad program translational potentials of their project. Next, students choose a clinical mentor, who plays an active role in shaping the student’s Ryan J. Hartmaier and Donald R. Shaffer project, meets regularly with the student and thesis committee, and helps to provide access to valuable patient samples. The The launch of the National Institutes of Health (NIH) roadmap in early marriage of a basic and clinical scientist on each student’s 2004 increased the biomedical community’s focus on advisory team sets the stage for fruitful collaborations and a truly translational research by designating significant funding for translational experience. discoveries in basic research that could lead to changes in patient Some of the best learning opportunities take place through care. Scientists who once lived at the bench are increasingly informal coffee shop meetings where a student discusses, with asked to support the clinical significance of their work. To both mentors, the details and direction of a project that will demonstrate their bench-to-bedside applicability, researchers simultaneously address a basic research question and have now feel encouraged to include patient sample analysis to diagnostic or therapeutic potential. The program puts graduate complement a mechanistic study or in vitro mechanistic data to students at the interface between basic science and the clinic, support a population study. -
Award Winning Research Kyoto University Is Acknowledged As One of the Most Accomplished Research-Oriented Universities in Asia
Award Winning Research Kyoto University is acknowledged as one of the most accomplished research-oriented universities in Asia. That reputation is 2016 testified by the accolades conferred on our alumni and researchers, most notably nine Nobel Prize laureates who undertook vital research during their time at the university. In addition to those awards, several other Kyoto University faculty members have received major accolades, including two Fields Medalists, one Gauss Prize winner, and five Lasker Award winners. Nobel Prize 1949, Physics 1965, Physics 1981, Chemistry 1987, Physiology and 2001, Chemistry Hideki Yukawa Shinichiro Tomonaga Kenichi Fukui Medicine Ryoji Noyori Susumu Tonegawa 2008, Physics 2008, Physics 2012, Physiology or 2014, Physics Makoto Kobayashi Toshihide Maskawa Medicine Isamu Akasaki Shinya Yamanaka Fields Medal Gauss Prize Kyoto Prize 1970, Mathematics 1990, Mathematics 2006, Mathematics 1995, Basic Sciences 1998, Basic Sciences 2004, 2010, Heisuke Hironaka Shigefumi Mori Kiyoshi Ito Chushiro Hayashi Kiyoshi Ito Advanced Technology Advanced Technology Alan Curtis Kay Shinya Yamanaka Japan Prize Lasker Award 2005, Information and 2005, Cell Biology 1987, Basic Medical 1989, Basic Medical 1998, Basic Medical 2009, Basic Medical 2014, Basic Medical Media Technology Masatoshi Takeichi Research Research Research Research Research Makoto Nagao Susumu Tonegawa Yasutomi Nishizuka Yoshio Masui Shinya Yamanaka Kazutoshi Mori *photos provided by the Japan Prize Foundation ©e Nobel Foundation2012 photo by Alexander Mahmoud Dr. Shinya Yamanaka, director of the Prof. Kayo Inaba, Kyoto University’s Prof. Kazutoshi Mori of Kyoto Center for iPS Cell Research and executive vice-president for gender University’s Graduate School of Science Application (CiRA), receives the 2012 equality, international affairs, and public receiving the 2014 Albert Lasker Award Nobel Prize in Physiology or Medicine. -
Ahmed Mohamed Fahmy Elwatidy, Md, Ms, Frcs
AHMED MOHAMED FAHMY ELWATIDY, MD, MS, FRCS, PhD Contact: +201146921922, +201282275517 | Email: [email protected] Professional Links: http://www.ctsnet.org/home/aelwatidy | https://www.linkedin.com/in/ahmed-elwatidy-23a8b826 | https://www.youtube.com/user/DrWatidy, https://www.researchgate.net/profile/Ahmed_Elwatidy PROFILE SUMMARY Cardiac Surgeon with 30 years of experience in management of cardiothoracic surgery patients. Handling all aspects of perioperative cardiac care from daily rounds to major cardiac surgical procedures, including postoperative intensive care management. With the merit of performing more than 5000 cardiac surgery operations; Coronary artery Bypass surgeries, all types of valve replacement surgeries, mitral and tricuspid repairs, Atrial fibrillation surgery (AF Ablation), Redo valve and coronary surgeries, heart failure surgery, left ventricular restoration, minimally invasive mitral and tricuspid surgery, TAVI and Aortic aneurysm surgery. Gained experience in Paediatric Cardiac Surgery including ASD, VSD, TOF, AVC, Aortic coarctation repair, and valve repair in grown up kids, PDA and PS. Senior decision-making capabilities especially during emergency situations and administrative Expertise as a director of cardiac center of excellence, and head of department of cardiac surgery. Active academically as a clinical associate professor, and investigator of many research projects. Innovator of many patent technologies and novel surgical techniques. Core Competencies: Coronary artery Bypass Surgery, Valve Replacement -
Lasker Interactive Research Nom'18.Indd
THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will -
Lasker Foundation 2019 Annual Report
Annual ALBERT AND MARY Report L ASKER FOUNDATION 2019 Annual Report 2019 1 LETTER FROM THE PRESIDENT & CHAIR OUR MISSION To improve health by accelerating support for medical research through recognition of research excellence, Communicating advocacy, and education. the Importance of Supporting Medical Research The Lasker Foundation celebrates the power of medical research, from fundamental science to initiatives expanding access to clinical advances. This year’s awards — serendipitously, all in the field of immunology — highlight this range. Max D. Cooper and Jacques Miller received the Albert Lasker Basic Medical Research Award for delineating the organizing principle of the adaptive immune system and launching the course of modern immunology. H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich were awarded the Lasker~DeBakey Clinical Medical Research Award for their invention of Herceptin® (trastuzumab), the first monoclonal antibody that blocks a cancer- causing protein, and for its development as a life-saving cancer therapy. The Lasker~Bloomberg Public Service Award was given to Gavi, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of vaccination to prevent disease. By shining a light on important advances, the Lasker Awards help us communicate to an international audience how scientific breakthroughs benefit us all. To accelerate support for science, we must ensure our message reaches all constituencies, including the public, scientists, policymakers, and donors. Lasker’s partnerships and programs also help achieve this goal. For example, our annual Public Lecture series connects accomplished scientists to the public to promote the understanding and the promise of biomedical science. -
2010 Lasker Awards Honor Trailblazers in Medical Research and Clinical Care
EMBARGOED FOR RELEASE UNTIL SEPTEMBER 21, 2010 at 12:01 AM EST Online Press Kit: http://laskerfoundation.presslift.com/2010 FROM: The Albert and Mary Lasker Foundation New York, New York CONTACT: Rubenstein Communications, Inc. Charles Zehren 212-843-8590 [email protected] Alison Hendrie 212-843-8029 [email protected] 2010 LASKER AWARDS HONOR TRAILBLAZERS IN MEDICAL RESEARCH AND CLINICAL CARE Douglas Coleman and Jeffrey M. Friedman, for the Discovery of Leptin, a Breakthrough that Revealed New Insight into the Genetic Basis of Obesity Napoleone Ferrara, for Using His Discovery of VEGF to Devise an Effective Treatment for Wet Macular Degeneration, a Leading Cause of Blindness in the Elderly David J. Weatherall, for Discoveries Concerning Genetic Diseases of the Blood and Improving Clinical Care for Children Throughout the Developing World. New York, Sept. 21, 2010 - The Albert and Mary Lasker Foundation, which for 65 years has championed the greatest advances in medical research, announced today the winners of the 2010 Lasker Awards: Douglas Coleman and Jeffrey M. Friedman for basic medical research, Napoleone Ferrara for clinical research and David J. Weatherall for special achievement. The three awards—recognized as the most prestigious medical research awards in the United States today—honor four visionaries whose insight and perseverance have led to dramatic advances that will prevent disease and prolong life. The Lasker Awards, which carry an honorarium of $250,000 for each category, will be presented at a ceremony on Friday, October 1, at the Pierre Hotel in New York City. Since 1945, the Lasker Awards program has recognized the contributions of scientists, physicians, and public servants internationally who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of human disease. -
Interview with Doctor Stanley B. Prusiner
Interview with Doctor Stanley B. Prusiner Interviewed by Doctor Douglas J. Lanska and Lauren E. Klaffke for the American Academy of Neurology Oral History Project at the Boston Convention & Exhibition Center Boston, Massachusetts Interviewed on April 27, 2017 Footnotes and Commentary by Douglas Lanska Transcription editing by Douglas Lanska and Lauren Klaffke Stanley B. Prusiner, MD, FAAN - SP Douglas J. Lanska, MD, MS, MSPH, FAAN - DL Lauren E. Klaffke - LK [Note: At DL’s invitation, SP agreed to a private and public interview at the annual meeting of the American Academy of Neurology, which was held in Boston in 2017. As DL arranged before the interview, the initial portion of the private interview was led by LK, with the final portion led by DL. The later public interview the same day was conducted by DL.] LK: This is Lauren Klaffke. It’s April 27, 2017. I’m here today with Dr. Doug Lanska to interview Dr. Stanley Prusiner in Boston at the annual meeting for the American Academy of Neurology. So, to get started, I wonder if you could tell me a little bit about your early life and education, growing up in Iowa and Ohio. SP: There’s not much to tell. It was a very uneventful time, at least from my point of view. I probably lived like most middle class people in a reasonable house. I had two wonderful parents.1 My brother2 and I recently reflected on our parents and what they gave us and did for us. That was a fantastic childhood when I look back on it. -
Nature Medicine Essay
LASKER CLINICAL MEDICAL RESEARCH AWARD COMMENTARY The surprising rise of nonthrombogenic valvular surgery Alain Carpentier Surgery has always been regarded as an art rather than a science—the art of curing dis- eases by manipulating instruments with one’s hands. In the past, progress resulted from the development of new ways of cutting, excising, resealing and suturing. Nowadays, this is no longer the case. My own specialty—cardiac surgery—did not exist 60 years ago. Its spectacular devel- opment would not have been possible with- out the contribution of basic sciences and engineering. Surgeons who participated in its development had to master these sciences. A visit to a cardiac surgery operating room may give an idea of the influence of these dis- ciplines. In a 50-square-meter room, a patient is lying on the operating table with his chest open and his beating heart exposed to the dazzling light of three “suns of crystal”, as Figure 1 First (homemade) glutaraldehyde-treated pig valve implanted in human. Left, Teflon-covered Paul Valery named the operating lights hang- stainless steel stent used to support the valve, preventing its deformation during implantation. Right, ing from the ceiling. Around the table, ten stent covered with Dacron fabric to facilitate fixation and host-tissue incorporation. The porcine valve phantom-like people, dressed from head to has been sutured into the stent preserving a full motion of the leaflets, avoiding fibrous incorporation. feet in blue gowns, bustle about, exchanging From ref. 6. few words. The patient’s life hangs on sophis- ticated machinery. Multiple tubes, wires, makers, defibrillators or cardiac-valve pros- that her life could be saved by oxygenating catheters connect him to monitoring devices, theses of different types are also available. -
Awards Season Is Upon Us
EDITORIAL Awards season is upon us… The 2009 Nobel Prize for Physiology or Medicine goes to telomerase researchers, the Lasker Award to nuclear reprogramming pioneers, and crystallographers are awarded the Chemistry Nobel once again. he trio who received the 2006 Albert Lasker Award for Basic disease, assess drug effectiveness and toxicity, and create tissue that Medical Research, Elizabeth Blackburn, Carol Greider and Jack might repair damage caused by injury or disease. TSzostak, have now been honored with the 2009 Nobel Prize in This year’s Nobel Prize in Chemistry has been awarded to Venki Physiology or Medicine for the discovery of “how chromosomes are Ramakrishnan, Thomas Steitz and Ada Yonath “for studies of protected by telomeres and the enzyme telomerase.” The ‘telomerase the structure and function of the ribosome.” Given that complex tale’ is well known—the discovery that the protection of chromosome problems—especially ones as complex as the unraveling of the ribosome ends by telomere DNA is evolutionarily conserved, and the isolation of structure—often require crucial input from many players, the Nobel enzymatic activity resulting in the synthesis of new telomeric DNA. (See committee undoubtedly had to make difficult choices. In some people’s a Commentary by the three awardees (Nat. Med. 12, 1133–1138, 2006) minds, Harry Noller—who was the first to suggest the “possibility and an Essay (Nat. Struct. Mol. Biol. 13, 1036–1038, 2006) by Vicki that 23S ribosomal RNA participates in the peptidyl transferase Lundblad, who was a postdoc with Szostak, recollecting her first-hand function” and who also made significant contributions to the ribosome experience of the unfolding of events.) structure—would have been a deserving winner.