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A Review of Microfluidic Concepts and Applications for Atmospheric Aerosol Science Aerosol Science and Technology ISSN: 0278-6826 (Print) 1521-7388 (Online) Journal homepage: http://www.tandfonline.com/loi/uast20 A review of microfluidic concepts and applications for atmospheric aerosol science Andrew R. Metcalf, Shweta Narayan & Cari S. Dutcher To cite this article: Andrew R. Metcalf, Shweta Narayan & Cari S. Dutcher (2018) A review of microfluidic concepts and applications for atmospheric aerosol science, Aerosol Science and Technology, 52:3, 310-329, DOI: 10.1080/02786826.2017.1408952 To link to this article: https://doi.org/10.1080/02786826.2017.1408952 View supplementary material Accepted author version posted online: 30 Nov 2017. Published online: 27 Dec 2017. Submit your article to this journal Article views: 206 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=uast20 AEROSOL SCIENCE AND TECHNOLOGY 2018, VOL. 52, NO. 3, 310–329 https://doi.org/10.1080/02786826.2017.1408952 A review of microfluidic concepts and applications for atmospheric aerosol science Andrew R. Metcalf *, Shweta Narayan , and Cari S. Dutcher Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA ABSTRACT ARTICLE HISTORY Microfluidics is used in a broad range of applications, from biology and medicine to chemistry and Received 27 October 2017 polymer science, because this versatile platform enables rapid and precise repeatability of Accepted 10 November 2017 measurements and experiments on a relatively low-cost laboratory platform. Despite wide-ranging EDITOR uses, this powerful research platform remains under-utilized by the atmospheric aerosol science Warren Finlay community. This review will summarize selected microfluidic concepts and tools with potential applications to aerosol science. Where appropriate, the basic operating conditions and tunable parameters in microfluidics will be compared to typical aerosol experimental methods. Microfluidics offers a number of advantages over larger-scale experiments; for example, the small volumes of sample required for experiments open a number of avenues for sample collection that are accessible to the aerosol community. Filter extraction, spot sampling, and particle-into-liquid sampling techniques could all be used to capture aerosol samples to supply microfluidic measurements and experiments. Microfluidic concepts, such as device geometries for creating emulsions and developments in particle and droplet manipulation techniques will be reviewed, and current and potential microfluidic applications to aerosol science will be discussed. 1. Introduction channels (Lee et al. 2017). For a more complete overview, Microfluidics is a large research field encompassing a in the online supplemental information (SI), Table S1 number of wide-ranging disciplines, such as engineering, has a comprehensive list of microfluidic applications and biology, medicine, and environmental monitoring. With review articles, SI Section 1 contains a brief history of miniaturization of fluid channels comes a number of key microfluidic advances since the 1970’s, and SI Section 2 advantages available to these disciplines. The photoli- has more details on fabrication techniques and materials thography techniques used to fabricate microfluidic devi- used in microfluidics. In general, these all-in-one micro- ces allow rapid prototyping at relatively low cost, which fluidic devices can include sample injection, movement, means that new applications for these devices can be eas- mixing, reaction, separation, and detection and are ily explored. Short length scales (see SEM images of appropriately called a “lab-on-a-chip” (Stone et al. 2004; microchannels in Figure 1) offer practical advantages, Whitesides 2006). such as smaller device footprints, making well-controlled Aerosol science can also tap into the benefits of using a thermal environments easier to obtain. Small devices microfluidic platform. Biphasic (droplet) microfluidics also lead to significantly reduced volumes of sample and can be used to (1) study interfacial phenomena of aerosol reagents necessary to conduct analyses, leading to lower chemical mimics using droplets (liquid–liquid interface) costs and expanding the number of sample collection or bubbles (liquid–air interface) and (2) encapsulate an techniques which may be employed. More advanced fab- aerosol particle in one phase (e.g., an aqueous phase for rication techniques produce multi-layered devices that dissolution of water-soluble species) for transport by an include pumps, valves, and mixing chambers on a single immiscible, carrier phase. Once in the device, rapid sort- device (Unger et al. 2000) and temperature measurement ing, manipulation, and measurements are possible with a and control alongside or embedded in fluid flow variety of geometries. Already, recent studies have begun CONTACT Cari S. Dutcher [email protected] Department of Mechanical Engineering, University of Minnesota, 11 Church St. SE, Minneapolis, MN 55455, USA. *Current affiliation: Department of Environmental Engineering and Earth Sciences, Clemson University, Anderson, South Carolina, USA Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/uast. Supplemental data for this article can be accessed on the publisher’s website. © 2018 American Association for Aerosol Research AEROSOL SCIENCE AND TECHNOLOGY 311 to observe specific phenomena which occur in atmo- spheric aerosol and will draw comparisons to single- particle techniques currently employed by the aerosol community. In each section, the similarities and differ- ences between the microfluidic framework and tradi- tional atmospheric aerosol science will be discussed. 2. Microscale phenomena 2.1. Dimensionless groups in microfluidic flow and aerosol science Several key dimensionless groups for single-phase and two-phase microfluidic flows are detailed below and com- pared to analogs in atmospheric and laboratory aerosol studies. One hallmark characteristic of microfluidic flow is that viscous forces dominate over inertial forces, resulting in laminar flow. This flow type can be described using the Reynolds number, Re, the ratio of inertial to viscous forces, Figure 1. Microfluidic channel masks (left) and SEM images of the and is most generally expressed as corresponding PDMS channels (right) of a T-junction (top) and co- flow with flow focusing (bottom) geometries. In the mask images Ul (left), arrows denoting continuous, dispersed, sheath, and emul- Re D ½1 sion flows show direction of flow and approximate relative veloci- n ties (proportional to arrow length) of the flow in each channel. where U is characteristic fluid velocity, l is characteristic to use microfluidics for measurements of interfacial ten- object length, and n is fluid kinematic viscosity. In a sion to characterize chemical mimics of atmospheric microfluidic device with a rectangular channel cross-sec- aerosol (Metcalf et al. 2016; Boyer and Dutcher 2017) and tion, U is typically the average velocity of fluid flow in for detection of bioaerosol hazards (Damit 2017). In the channel and l is the hydraulic diameter of the flow recent development of low-cost sensors, microfluidic and channel (Gravesen et al. 1993; Christopher and Anna micro electromechanical systems (MEMS) devices have 2007). Typical channel dimensions and flow rates used seen increasing application, such as the air-microfluidics in microfluidic devices lead to Re 1, which is laminar based PM 2.5 sensor that can be used for affordable per- flow (Purcell 1977). Atmospheric aerosol scientists typi- sonal monitoring of hazards such as tobacco smoke or cally consider Re from two perspectives. The first is for diesel exhaust (Paprotny et al. 2013). In addition, a micro- the flow of particle-laden air in a sampling tube of an fluidic nebulizer could improve the monodispersity of instrument, which is typically desired to be laminar flow aerosol populations for calibration of traditional aerosol (Re < 2000) to reduce the amount of particle losses due sampling instruments (Amstad et al. 2017). to inertial deposition onto the tubing walls. The second This review will describe selected microfluidic con- perspective is for particle Reynolds number, Rep, cepts from the perspective of atmospheric aerosol in which flow is considered laminar for Rep < » 0:1 science. Where appropriate, current applications of (Kulkarni et al. 2011). In a channel, Re characterizes microfluidics to aerosol science will be reviewed, and whether fluid flow is turbulent or laminar and a similar- potential applications will be presented. Section 2 will ity in Re means a similarity in flow kinematics (Hinds discuss basic microfluidic flow concepts with compari- 1999). sons to typical atmospheric aerosol analogues. A review Figure 2 displays a comparison of flow regimes over a of selected microfluidic experimental capabilities, range of microfluidic and aerosol particle sampling con- including control by electrical, chemical, and tempera- ditions. The key difference between the microfluidic ture gradients, will demonstrate the versatility of framework and the aerosol sampling regime in Figure 2 the microfluidic platform. Section 3 will discuss using is that microfluidics usually involves the flow of liquid microfluidics as a measurement platform to characterize and aerosol sampling involves the flow of particle-laden physical, chemical, and thermodynamic properties of air. The orders of magnitude difference in viscosity and fluids relevant to atmospheric
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