Professor Sir David Weatherall

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Scientist of the Month Professor Sir David Weatherall Sir David John Weatherall was born in Birkenhead on 9th March, 1933: his research interests are on the genetics of the haemoglobinopathies and, in particular, a group of inherited haematological disorders known as the thalassemias that are associated with abnormalities in the production of globin (the protein component of haemoglobin). Sir David is one of the world's experts on the clinical and molecular basis of the thalassemias and the application of this information for the control and prevention of these diseases in the developing countries. He was educated at Calday Grange Grammar School and then graduated from the Medical School at the University of Liverpool in 1956. After house staff training, he joined the Army for 2 years. Returning from military service, he took a fellowship at Johns Hopkins University before returning to Liverpool, where he rose to the rank of Professor of Haematology. In 1974 he was appointed Nuffield Professor of Clinical Medicine at the University of Oxford, and, in 1992, he assumed the most prestigious chair, that of Regius Professor of Medicine, from 1992 to 2000. In 1989, Weatherall founded the Institute of Molecular Medicine at Oxford, which was renamed the Weatherall Institute of Molecular Medicine in his honour in the year 2000 upon his retirement. He then became Chancellor of Keele University. He was a member of the Nuffield Council on Bioethics 1991‐1996. In 2002, Weatherall wrote a major report on the application of genomics for global health for the World Health Organization. Sir David is a Distinguished Supporter of the British Humanist Association. In 2009, a working group report under the Chairmanship of Professor Weatherall concludes that there is a strong scientific case to maintain biomedical research activities using non‐ human primates in carefully selected areas. He was knighted in 1987 and Sir David was awarded the Manson Medal by the Royal Society of Tropical Medicine and Hygiene for his contributions to the field of tropical medicine and hygiene in 1998. In 2012, Keele University named the Medical School building on the Keele Campus the David Weatherall Building in honour of Sir David. .

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The Future Role of Molecular and Cell Biology in Medical Practice in the Tropical Countries
The future role of molecular and cell biology in medical practice in the tropical countries David Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK Downloaded from https://academic.oup.com/bmb/article/54/2/489/285007 by guest on 27 September 2021 Molecular and cell biology have a great deal to offer tropical medicine in the future. As well as helping to understand the population genetics and dynamics of both infectious and non-infectious diseases, they promise to provide a new generation of diagnostic and therapeutic agents, and to play a major role in the development of new vaccines and other approaches to the control of disease in tropical communities. Over the last 20 years there has been a gradual shift in the emphasis of basic biomedical research from the study of disease in patients and their organs to its definition at the level of molecules and cells. This new trend has been underpinned by a remarkable new technology which has made it possible to isolate and sequence genes, study their function and transfer them across the species barrier. In the short time during which this field has evolved, a great deal has been discovered about human pathology at the molecular level. Many monogenic diseases have been characterised, much has been learnt about the molecular and cell biology of cancer, and a start has been made in defining the different genes that comprise the complex interactions between nature and nurture that underlie many of the major killers of Western society. Enough is known already to suggest that this knowledge will have major implications for the development of more precise diagnostic and therapeutic agents in the future.
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Clinical Genetics in Britain: Origins and Development Harper, PS; REYNOLDS, LA; TANSEY, EM
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