AMP Molecular Pathology Book List
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The Future Role of Molecular and Cell Biology in Medical Practice in the Tropical Countries
The future role of molecular and cell biology in medical practice in the tropical countries David Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK Downloaded from https://academic.oup.com/bmb/article/54/2/489/285007 by guest on 27 September 2021 Molecular and cell biology have a great deal to offer tropical medicine in the future. As well as helping to understand the population genetics and dynamics of both infectious and non-infectious diseases, they promise to provide a new generation of diagnostic and therapeutic agents, and to play a major role in the development of new vaccines and other approaches to the control of disease in tropical communities. Over the last 20 years there has been a gradual shift in the emphasis of basic biomedical research from the study of disease in patients and their organs to its definition at the level of molecules and cells. This new trend has been underpinned by a remarkable new technology which has made it possible to isolate and sequence genes, study their function and transfer them across the species barrier. In the short time during which this field has evolved, a great deal has been discovered about human pathology at the molecular level. Many monogenic diseases have been characterised, much has been learnt about the molecular and cell biology of cancer, and a start has been made in defining the different genes that comprise the complex interactions between nature and nurture that underlie many of the major killers of Western society. Enough is known already to suggest that this knowledge will have major implications for the development of more precise diagnostic and therapeutic agents in the future. -
Molecular Medicine Degree: Doctor of Philosophy (Phd)
In the Name of God Islamic Republic of Iran Ministry of Health and Medical Education Deputy for Education Molecular Medicine Degree: Doctor of Philosophy (PhD) Total Course Credits Core: 24 Non-core (Electives): 6 Dissertation: 20 Program Description Although the concept of molecular medicine was introduced in 1949, a great deal of developments in this filed, especially in European and American countries, has taken place during recent years. Bearing in the mind the strategic significance of this area of knowledge, a considerable number of universities worldwide grant scholarships annually to students of this field of study. Iranian universities inaugurated Molecular Medicine in 2007 and due to the urgent escalating need for graduates of molecular medicine each year, an increasing number of universities receive students in this major. Molecular medicine, as an interdisciplinary field of study, contributes to understanding the molecular basis of the etiology and mechanisms of diseases and various disorders along with fundamental and heuristic research on different areas of diseases including prevention, diagnosis, and treatment. Dissemination of the science of molecular medicine through a blend of education and clinical research emphasizing active learning and up-to-date research will significantly contribute to the expansion of the borders of medicine and eventually improvement of health in society. Among the values of the field are practicing creativity and innovation to analyze lessons learned and research to utilize molecular medicine findings to solve problems related to public health. In this regard, graduates focus on social justice and human equality, the rights of patients, regardless of age, sex, color, race, culture and religion and any activity would be with regard to the protection of human dignity. -
The Next Big Thing in Chromatography?
The Next Big Thing In Chromatography? Find out how microscale chromatography is making a big splash in analytical science Please click the circles to navigate Technology Perfecting Chromatography Technical & with a Real Proteomic Peaks in Silicon Application Edge Separations Valley Notes PERFECTING CHROMATOGRAPHY TECHNOLOGY WITH TECHNICAL & PROTEOMIC PEAKS IN SILICON A REAL EDGE APPLICATION NOTES SEPARATIONS VALLEY μPAC™ at the Edge As uptake of μPAC™ grows, the technology is contributing to exciting advances in biology and beyond. Here are just three projects that hit the headlines in 2019… Tree of Life At the EMBL Wellcome Genome Campus Conference in March 2019, the Matthias Mann Group (Max Planck Institute, Munich, Germany) presented the quantitative proteome atlas of 100 organisms across all three kingdoms, fingerprinted thanks to the high retention time stability and reproducibility of the μPAC™. The Tree of Life is the largest open access proteome data set ever reported, with more than 250,000 proteins, and growing. Labs around the world can use the open access database together with μPAC™ and machine learning to predict a retention time fingerprint for each individual protein in the Tree of Life – the potential for hyper-resolved target data deconvolution is immense. Doubling Up on Single Cells Single-cell proteomics is poised to revolutionize many fields of biological research, with important implications for therapeutics, discovery, genomics and translational research. In a presentation titled “Double protein IDs in Single Cell protocols”, Karl Mechtler (Institute of Molecular Pathology, Vienna) explained how his group have identified 3,500 Brussel in late 2010 and set up shop as a microfluidics consulting proteins in a 10 ng HeLa cell sample using the μPAC™ Technology with a Real Edge boutique. -
University of Wolverhampton
Course Specification Published Date: 14-Sep-2020 Produced By: Laura Clode Status: Validated Core Information Awarding Body / Institution: University of Wolverhampton School / Institute: Wolverhampton School of Sciences Course Code(s): BM021K23UV Sandwich 4 Years UCAS Code: B991 Course Title: BSc (Hons) Biomedical Science with Sandwich Placement Hierarchy of Awards: Bachelor of Science with Honours Biomedical Science, having satisfactorily completed a sandwich placement Bachelor of Science with Honours Biomedical Science, having satisfactorily completed a sandwich placement Bachelor of Science Medical Laboratory Science, having satisfactorily completed a sandwich placement Bachelor of Science Biomedical Science, having satisfactorily completed a sandwich placement Diploma of Higher Education Medical Laboratory Science Certificate of Higher Education Medical Laboratory Science University Statement of Credit University Statement of Credit Language of Study: English Date of DAG approval: 05/Jun/2018 Last Review: 2017/8 Course Specification valid from: 2010/1 Course Specification valid to: 2023/4 Academic Staff Course Leader: Dr Elizabeth O'Gara Head of Department: Dr Elizabeth O'Gara Course Information Location of Delivery: University of Wolverhampton Category of Partnership: Not delivered in partnership Teaching Institution: University of Wolverhampton Open / Closed Course: This course is open to all suitably qualified candidates. Entry Requirements: Entry requirements are subject to regular review. The entry requirements applicable to a particular academic year will be published on the University website (and externally as appropriate e.g. UCAS 240 UCAS points including a science subject at A-level or equivalent. GCSE English and Maths at grade C or above. Distinctive Features of the Course: This course involves the study of a variety of biomedical science disciplines and takes place at an institution where fellow students are undertaking programmes in other disciplines and vocational courses in a wide variety of medicine-related subjects. -
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
1 What Is Pathology? James C
1 What is pathology? James C. E. Underwood History of pathology 4 Making diagnoses 9 Morbid anatomy 4 Diagnostic pathology 9 Microscopic and cellular pathology 4 Autopsies 9 Molecular pathology 5 Pathology, patients and populations 9 Cellular and molecular alterations in disease 5 Causes and agents of disease 9 Scope of pathology 5 The health of a nation 9 Clinical pathology 5 Preventing disability and premature death 9 Techniques of pathology 5 Pathology and personalised medicine 10 Learning pathology 7 Disease mechanisms 7 Systematic pathology 7 Building knowledge and understanding 8 Pathology in the problem-oriented integrated medical curriculum 8 3 PatHOLOGY, PatIENTS AND POPULatIONS 1 Keywords disease diagnosis pathology history 3.e1 1 WHat IS patHOLOGY? Of all the clinical disciplines, pathology is the one that most Table 1.1 Historical relationship between the hypothetic directly reflects the demystification of the human body that has causes of disease and the dependence on techniques for made medicine so effective and so humane. It expresses the truth their elucidation underpinning scientific medicine, the inhuman truth of the human body, and disperses the mist of evasion that characterises folk Techniques medicine and everyday thinking about sickness and health. Hypothetical supporting causal From: Hippocratic Oaths by Raymond Tallis cause of disease hypothesis Period Animism None Primitive, although Pathology is the scientific study of disease. Pathology the ideas persist in comprises scientific knowledge and diagnostic methods some cultures essential, first, for understanding diseases and their causes and, second, for their effective prevention and treatment. Magic None Primitive, although Pathology embraces the functional and structural changes the ideas persist in in disease, from the molecular level to the effects on the some cultures individual patient, and is continually developing as new research illuminates our knowledge of disease. -
Molecular Diagnostic Testing for Hematology and Oncology Indications Table of Contents Related Coverage Resources
Effective February 15, 2021 Medical Coverage Policy Effective Date.............................................. 2/15/2021 Next Review Date ..................................... 11/15/2021 Coverage Policy Number ................................... 0520 Molecular Diagnostic Testing for Hematology and Oncology Indications Table of Contents Related Coverage Resources Overview ....................................................................... 2 Genetics Coverage Policy ........................................................... 2 Genetic Testing Collateral File General Criteria for Somatic Pathogenic or Likely Pathogenic Variant Genetic Testing ........................... 2 Tumor Profile/Gene Expression Classifier Testing - ...................................................................... 3 Prostate Cancer Screening and Prognostic Tests ..... 6 Tumor Tissue-Based Molecular Assays for Prostate Cancer .......................................................... 6 Hematologic Cancer and Myeloproliferative and Myelodysplastic Disease ............................................ 7 Occult Neoplasms ....................................................... 8 Solid Tumor Cancers .................................................. 9 Other Tumor Profile Testing ....................................... 9 General Background .................................................... 9 General Criteria for Somatic Mutation Genetic Testing ........................................................................ 9 Tumor Profile/Gene Expression Classifier Testing -
BRCA1/2 Mutation Detection in the Tumor Tissue from Selected Polish Patients with Breast Cancer Using Next Generation Sequencing
G C A T T A C G G C A T genes Article BRCA1/2 Mutation Detection in the Tumor Tissue from Selected Polish Patients with Breast Cancer Using Next Generation Sequencing Ewelina Szczerba 1,2, Katarzyna Kami ´nska 1, Tomasz Mierzwa 3, Marcin Misiek 4, Janusz Kowalewski 2 and Marzena Anna Lewandowska 1,2,* 1 The F. Lukaszczyk Oncology Center, Molecular Oncology and Genetics Department, Innovative Medical Forum, 85-796 Bydgoszcz, Poland; [email protected] (E.S.); [email protected] (K.K.) 2 Department of Thoracic Surgery and Tumors, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-067 Torun, Poland; [email protected] 3 The F. Lukaszczyk Oncology Center, Department of Prevention and Health Promotion, 85-796 Bydgoszcz, Poland; [email protected] 4 Swi˛etokrzyskieCancer´ Center, Clinical Department of Gynaecological Oncology, 25-734 Kielce, Poland; [email protected] * Correspondence: [email protected] Abstract: (1) Background: Although, in the mutated BRCA detected in the Polish population of patients with breast cancer, there is a large percentage of recurrent pathogenic variants, an increasing need for the assessment of rare BRCA1/2 variants using NGS can be observed. (2) Methods: We studied 75 selected patients with breast cancer (negative for the presence of 5 mutations tested in the Polish population in the prophylactic National Cancer Control Program). DNA extracted from Citation: Szczerba, E.; Kami´nska,K.; the cancer tissue of these patients was used to prepare a library and to sequence all coding regions Mierzwa, T.; Misiek, M.; Kowalewski, of the BRCA1/2 genes. -
Clinical Genetics in Britain: Origins and Development
CLINICAL GENETICS IN BRITAIN: ORIGINS AND DEVELOPMENT The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 23 September 2008 Edited by P S Harper, L A Reynolds and E M Tansey Volume 39 2010 ©The Trustee of the Wellcome Trust, London, 2010 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 127 1 All volumes are freely available online following the links to Publications/Wellcome Witnesses at www.ucl.ac.uk/histmed CONTENTS Illustrations and credits v Abbreviations vii Witness Seminars: Meetings and publications; Acknowledgements E M Tansey and L A Reynolds ix Introduction Sir John Bell xix Transcript Edited by P S Harper, L A Reynolds and E M Tansey 1 Appendix 1 Initiatives supporting clinical genetics, 1983–99 by Professor Rodney Harris 83 Appendix 2 The Association of Genetic Nurses and Counsellors (AGNC) by Professor Heather Skirton 87 References 89 Biographical notes 113 Glossary 133 Index 137 ILLUSTRATIONS AND CREDITS Figure 1 Professor Lionel Penrose, c. 1960. Provided by and reproduced with permission of Professor Shirley Hodgson. 8 Figure 2 Dr Mary Lucas, clinical geneticist at the Galton Laboratory, explains a poster to the University of London’s Chancellor, Princess Anne, October 1981. Provided by and reproduced with permission of Professor Joy Delhanty. 9 Figure 3 (a) The karyotype of a phenotypically normal woman and (b) family pedigree, showing three generations with inherited translocation. -
Clinical Molecular Genetics in the Uk C.1975–C.2000
CLINICAL MOLECULAR GENETICS IN THE UK c.1975–c.2000 The transcript of a Witness Seminar held by the History of Modern Biomedicine Research Group, Queen Mary, University of London, on 5 February 2013 Edited by E M Jones and E M Tansey Volume 48 2014 ©The Trustee of the Wellcome Trust, London, 2014 First published by Queen Mary, University of London, 2014 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 90223 888 6 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/ wellcome_witnesses/ Please cite as: Jones E M, Tansey E M. (eds) (2014) Clinical Molecular Genetics in the UK c.1975–c.2000. Wellcome Witnesses to Contemporary Medicine, vol. 48. London: Queen Mary, University of London. CONTENTS What is a Witness Seminar? v Acknowledgements E M Tansey and E M Jones vii Illustrations and credits ix Abbreviations xi Ancillary guides xiii Introduction Professor Bob Williamson xv Transcript Edited by E M Jones and E M Tansey 1 Appendix 1 Photograph, with key, of delegates attending The Molecular Biology of Thalassaemia conference in Kolimbari, Crete, 1978 88 Appendix 2 Extracts from the University of Leiden postgraduate course Restriction Fragment Length Polymorphisms and Human Genetics, 1982 91 Appendix 3 Archival material of the Clinical Molecular Genetics Society 95 Biographical notes 101 References 113 Index 131 Witness Seminars: Meetings and Publications 143 WHAT IS A WITNESS SEMINAR? The Witness Seminar is a specialized form of oral history, where several individuals associated with a particular set of circumstances or events are invited to meet together to discuss, debate, and agree or disagree about their memories. -
Whole Genome Sequencing in Oncology: Using Scenario Drafting to Explore Future Developments Michiel Van De Ven1†, Martijn J
Ven et al. BMC Cancer (2021) 21:488 https://doi.org/10.1186/s12885-021-08214-8 RESEARCH ARTICLE Open Access Whole genome sequencing in oncology: using scenario drafting to explore future developments Michiel van de Ven1†, Martijn J. H. G. Simons2,3†, Hendrik Koffijberg1, Manuela A. Joore2,3, Maarten J. IJzerman1,4,5, Valesca P. Retèl1,6*† and Wim H. van Harten1,6,7† Abstract Background: In oncology, Whole Genome Sequencing (WGS) is not yet widely implemented due to uncertainties such as the required infrastructure and expertise, costs and reimbursements, and unknown pan-cancer clinical utility. Therefore, this study aimed to investigate possible future developments facilitating or impeding the use of WGS as a molecular diagnostic in oncology through scenario drafting. Methods: A four-step process was adopted for scenario drafting. First, the literature was searched for barriers and facilitators related to the implementation of WGS. Second, they were prioritized by international experts, and third, combined into coherent scenarios. Fourth, the scenarios were implemented in an online survey and their likelihood of taking place within 5 years was elicited from another group of experts. Based on the minimum, maximum, and most likely (mode) parameters, individual Program Evaluation and Review Technique (PERT) probability density functions were determined. Subsequently, individual opinions were aggregated by performing unweighted linear pooling, from which summary statistics were extracted and reported. Results: Sixty-two unique barriers and facilitators were extracted from 70 articles. Price, clinical utility, and turnaround time of WGS were ranked as the most important aspects. Nine scenarios were developed and scored on likelihood by 18 experts. -
The Era of Transformative Molecular Oncology
LURIE CANCER CENTER ONCOSET SYMPOSIUM The Era of Transformative Molecular Oncology Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chairs: Leonidas Platanias, MD, PhD Massimo Cristofanilli, MD Date: March 19, 2021 VIRTUAL EVENT - 9:00 A.M. - 4:30 P.M. CENTRAL TIME | MATERIALS AVAILABLE THROUGH APRIL 2 Lurie Cancer Center OncoSET Symposium: The Era of Transformative Molecular Oncology OPENING REMARKS 9:00 a.m. Welcome Leonidas Platanias, MD, PhD and Massimo Cristofanilli, MD Lurie Cancer Center KEYNOTE ADDRESS 9:05 a.m. The Evolution of Molecular Oncology: Actionable, Druggable, Undruggable? David Hong, MD The University of Texas MD Anderson Cancer Center SESSION 1: Molecularly Targeted Therapies and Immune Therapy Selection Co-Chairs: Amir Behdad, MD and Young Chae, MD, MPH, MBA, Lurie Cancer Center 9:45 a.m. The Central Role of Tumor and Germline DNA Alterations in Cancer Treatment Pamela Munster, MD UCSF Helen Diller Family Comprehensive Cancer Center 10:15 a.m. The Implementation of Precision Medicine in an Academic Center: It Takes a Village Milan Radovich, PhD Indiana University Simon Cancer Center 10:50 a.m. Panel Discussion 11:10 a.m. Break & Exhibits SESSION 2: Evolving Role of Liquid Biopsy: Detection, Monitoring and Early Detection Co-Chairs: Massimo Cristofanilli, MD and Dai Horiuchi, PhD, Lurie Cancer Center 11:40 p.m. Liquid Biopsy in Cancer Diagnostics: Fulfilling the Dream of Earlier Detection? Nickolas Papadopoulos, PhD Johns Hopkins Medicine 12:10 p.m. Precision Medicine Delivery in Metastatic Prostate Cancer: Foresight “2020” Manish Kohli, MD Huntsman Cancer Institute - University of Utah Health 12:50 p.m.