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Forensic Detection

ELISA Test Kits and Reagents Oral Fluid Collection System Automated Equipment

Simple Sensitive Solutions Your Complete Forensic Drug Detection Source

Neogen Corporation develops, manufactures, and markets a diverse line of products used to provide solutions for drug detection, and food and animal safety. Founded in 1982, Neogen (NASDAQ: NEOG) has grown to more than 1,000 employees with multiple U.S. and international locations, and a worldwide presence. Neogen’s more than 30 years spent developing and manufacturing enzyme- linked immunosorbent assay (ELISA) test kits has produced the highest quality, most dependable reagents with excellent reproducibility and sensitivity. Our comprehensive line of drug detection assays includes more than 115 ELISA kits that can be used to screen more than 300 and/or their metabolites in a wide range of forensic matrices. Our test kits are qualitative one-step kits intended as screening devices for the detection of drugs and/ or their metabolites in forensic samples only. Suspect samples should be confirmed by a quantitative method, such as GC/MS. Our easy-to-use protocols are designed for high and low volume laboratories as they can be run manually or easily automated on a wide range of immunoassay instruments. Neogen’s experienced technical support staff is available to discuss your testing and automation requirements to find a system that will work best for your applications. With our experienced research and development teams, and flexible operations, Neogen can quickly respond to rapidly evolving needs in the forensic market. Neogen believes that maintaining earned trust is a combination of innovation and a continuous commitment to quality. Neogen’s quality management system is ISO 9001 certified, which communicates to the company’s worldwide customer base that it understands the quality standards customers expect, and is firmly committed to achieving those quality standards. Neogen’s continuing record of exceptional performance has earned it increasing recognition, including being repeatedly named as one of Forbes Magazine’s Best Small Companies in America; being named to Fortune Magazine’s prestigious list of 40 Stocks To Retire On; and being selected to NASDAQ’s top tier of companies, the NASDAQ Global Select Market.

Neogen’s drug detection product line offers: Neogen offers products for multiple drug panels: • More than 100 drug detection test kits • • Validation for forensic matrices: whole blood, urine, hair, oral fluid, • Anabolic Steroids/Beta- serum, plasma, meconium, breast milk and others • and Anesthetics • High sensitivity • / • Excellent reproducibility • • Automated and semi-automated equipment packages • Anti-Inflammatories • Reagent Rental Program • • Customized single-line reporting software • Other Prescription Drugs • More than 30 years of ELISA experience • Workplace Testing • Designer Drugs

2 To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com Drug Detection ELISA Panels

Stimulants Narcotic Analgesics Other Prescription Drugs • • 6-AM • Amphetamine • Amphetamine Specific-2 • • Amphetamine Specific-2 • Amphetamine Ultra • • Amphetamine Ultra • (BZP) • • Barbiturate Group • /Pentoxifylline • Buprenorphine/ • Benzodiazepine Group (Oxazepam/Clonazepam) • /BZE • • Buprenorphine • • • Buprenorphine/Norbuprenorphine • Doxapram • • Butorphanol • /Mazindol Metabolites • • Carisoprodol • • • • /MDMA • Fentanyl • • • • Hydrochlorothiazide • Synthetic () • • Hydromorphone • • Anabolic Steroids/Beta-Agonists • Meperidine Enhanced • Meperidine Enhanced Anabolic Steroids • • Methadone • 16ß-Hydroxystanozolol • Methadone/LAAM • Methadone/LAAM • Boldenone • / • Methamphetamine/MDMA • Nandrolone • • Methylphenidate • Stanozolol • / • Naltrexone/Nalbuphine • Trenbolone • • Group • Propoxyphene • Oxycodone/Oxymorphone Beta-Agonists • • Pentazocine • Bronchodilator Group • • Phenytoin • • Propoxyphene • Ractopamine Anti-Inflammatories • Tramadol • • Carprofen • Trazodone • • Zolpidem Hallucinogens & Anesthetics • Corticosteroid Group • • Dexamethasone Workplace Testing • Ketamine • Flunixin • 6-AM • Lidocaine • • Amphetamine • LSD • • Amphetamine Specific-2 • Mepivacaine • Methylprednisolone • Amphetamine Ultra • PCP • Phenylbutazone • Barbiturate Group • Procaine • Salicylates • Benzodiazepine Group • THC • Triamcinolone Acetonide • Buprenorphine • Synthetic Cannabinoids • Zomepirac • Cocaine/BZE • Methadone Antidepressants/Sedatives Antipsychotics • Methamphetamine/MDMA • • • Opiates • Barbiturate Group • • Oxycodone/Oxymorphone • Benzodiazepine Group (Oxazepam/Clonazepam) • • PCP • • Haloperidol Metabolites • Propoxyphene • Citalopram • Group • THC • Detomidine • Tricyclics Group • Flunitrazepam Designer Drugs • Fluoxetine • Synthetic Cannabinoids (JWH-018) • • Synthetic Cannabinoids (JWH-250) • Reserpine • Synthetic Cannabinoids (UR-144/XLR-11) • Sertraline • Synthetic Cathinones (Methcathinone) • Trazodone • Designer Benzodiazepines • Tricyclics Group • Zolpidem

FOR FORENSIC USE ONLY

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com 3 Drug Detection ELISA Kits

ELISA Test Kits Product No. ELISA Test Kits Product No. ELISA Test Kits Product No. 6-AM 134019 Ibuprofen 180219 Sufentanil 104919 16β-Hydroxystanozolol 103519 Ipratropium/ 107119 Sulfamethazine 103419 Acetaminophen 132419 Isoxsuprine 102219 Synthetic Cannabinoids (JWH-018) 133519 Alfentanil 103619 Ketamine 131719 Synthetic Cannabinoids (JWH-250) 133719 Amphetamine 105219-1 108219 Synthetic Cannabinoids Amphetamine Specific-2 132319-2 Ketorolac 105619 (UR-144/XLR-11) 133919 Amphetamine Ultra 130819 Levallorphan 102319 Synthetic Cathinones (Methcathinone) 181819 Anileridine 105519 Lidocaine 106719-1 THC 131019 /Apocodeine 109119 Lofentanil 102419 Theophylline 106019 Azaperone 100919 LSD 130219 Tramadol 131819 Barbiturate Group 130619 Mazindol/Mazindol Metabolites 102519 Trazodone 132819 Benzodiazepine Group Meperidine 131219 Trenbolone 109719 (Oxazepam/Clonazepam) 130119 107219 Triamcinolone Acetonide 105119 Benzylpiperazine 108319 Mepivacaine 102719 Tricyclics Group 132019 Boldenone 101019 Meprobamate 133419 Zolpidem 132619 Bronchodilator Group 100319 107919 Zomepirac 109619 Bumetanide 103719-1 Methadone 131619 Zopiclone/Eszopiclone 133819 Buprenorphine 131919 Methadone/LAAM 132919 Buspirone* 108719 Methamphetamine/MDMA 130919 Hair ELISA Kits** Product No. Butorphanol 101119 Methocarbamol 108019 Cocaine/BZE 140119 Caffeine/Pentoxifylline 106419 Methotrexate 107519 Methamphetamine 140219 Carfentanil 103919 Methylphenidate 133219 Opiates 140319 Carisoprodol 132519 Methylprednisolone 104519 Synthetic Opiates 140419 Carprofen 181119 Naltrexone/Nalbuphine 133019 PCP 140519 Celecoxib 180719 Nandrolone 104619 THC 140619 **Not sold in the U.S. Citalopram 132719 Nikethamide 109919  Clenbuterol 101219 Opiate Group 130419 Oral Fluid ELISA Kits Product No. Clonidine/Romifidine 180119 Oxycodone/Oxymorphone 130719 Cocaine/BZE 120119 Cocaine/Benzoylecgonine 130319 Pentazocine 103119 Methamphetamine 120219 Corticosteroid Group 100419 (PCP) 130519 Opiates 120319 Cotinine (Serum) CT-96-S Phenylbutazone 104719-1 PCP 120419 Cotinine (Urine) CT-96-U Phenytoin 132119 THC 120519 Creatinine 133319 Procaine 103219 Multi-Analyte Calibrator Set 128100 Cromoglycate 105819 Promazine Group 100719 Dantrolene 106319 Propoxyphene 131119 FOR FORENSIC USE ONLY Dermorphin 181919 Propranolol 107319 j Detomidine 181319 Pyrilamine 105919 New kits Dexamethasone 101519 Ractopamine 106519  Ready-to-use (RTU) Assay Dextromethorphan 131419 Reserpine 104819  Matrix specific calibrators included Diprenorphine* 106119 Salicylates 133619 Other kits include positive and negative controls Doxapram 106219 Sertraline 131319 Neogen’s ready-to-use or RTU test kits require no pre-dilution of Droperidol 101619 Stanozolol 103319 conjugate prior to assay set-up. Ethacrynic Acid 101719-1 Etorphine 101819 Fenspiride* 108419 Fentanil Group 100519 Fentanyl 131519 Fexofenadine/Terfenadine* 181419 Flunitrazepam 109519 Flunixin 101919 Fluoxetine 107619 Fluphenazine 104119 Furosemide 104219-1 Glycopyrrolate 102019 Guanabenz 109219 Haloperidol Metabolites 102119 Neogen’s Ready-to-Use (RTU) Forensic Assays Hydrochlorothiazide 180319 Neogen offers forensic assays that are ready to use and that do not require pre-dilution of reagents Hydromorphone 132219 prior to assay setup. Matrix specific quantitative calibrators or qualitative positive or negative controls Hydroxyzine 105719 are assay-specific. See the product list or contact a forensic representative for details regarding a * Minimum quantities and lead times required. specific kit. Contact Neogen for more details.

4 To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com Oral Fluid Testing

Oral Fluid Testing Neogen’s oral fluid product line includes the NeoSal™ Oral Fluid Collection System and a panel of oral fluid ELISA test kits optimized with the NeoSal device. The NeoSal Oral Fluid Collection System is designed for maximum ease-of-use when collecting and testing oral fluid samples for drugs of abuse.

NeoSal Key Features We also offer the UltraSal-2, a split-specimen oral fluid collection device that can be used for multiple testing applications. • Sample Volume Adequacy Indicator (SVAI) UltraSal-2 Key Features • -free collection pad • Neat saliva collection • Quick collection, typically 1 to 2 • Graduated volume minutes indicator • Unique handle fits directly • Split-sample collection into buffer tube and prevents • Ideal for research sample contamination applications • No additional sample UltraSal-2 processing required • Automation friendly, fits onto 12 X 75 sample racks • Consistent drug recovery NeoSal Oral Fluid NeoSal 25-pack product #128101-25 Collection System UltraSal-2 50-pack product #US2-50

Oral Fluid ELISA Kits Features of Neogen’s Oral Fluid ELISA Kits: Neogen has expanded its forensic drug detection product line by adding • Optimized with the NeoSal Oral Fluid Collection System panel of oral fluid ELISA kits for Cocaine/BZE, Methamphetamine, Opiates, • High sensitivity PCP and THC. • Excellent reproducibility • Compatible with automated and semi-automated equipment • Available in 96 and 480 well assay Neogen’s Oral Fluid ELISA Kits Kit Name Product No. Cocaine/BZE 120119 Methamphetamine 120219 Opiates 120319 PCP 120419 THC 120519 Multi-Analyte Calibrator Set 128100

FOR FORENSIC USE ONLY

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com 5 Hair ELISA Drug Kits

Neogen has expanded its forensic drug detection product line by adding hair testing ELISA kits for the most commonly abused drugs on the illicit market—Cocaine, Methamphetamine, Opiates, Synthetic Opiates, PCP, and THC. Using hair samples to detect drugs of abuse has become common practice because of its advantages over traditional sample types. Advantages include: • Hair is easy to handle and store • Collection is far less invasive than urine and blood • Brief periods of non-use do not affect test results • A larger window of drug detection • Simple retesting • Difficult to adulterate test results These advantages have led hair samples to be extensively used in workplace testing, as well as in other areas, such as legal cases, occupational and traffic medicine, and for historical research. Intended Use Neogen's Hair ELISA Kits For the determination of trace quantities of drug analytes in human hair samples. Kit Name Product No. Cocaine 140119 Features of Neogen’s Hair ELISA Kits: • High sensitivity Methamphetamine 140219 • Excellent reproducibility Opiates 140319 • Compatible with automated and semi-automated equipment Synthetic Opiates 140419 • Available in 96 and 480 well assay PCP 140519 THC 140619 Not sold in the U.S.

FOR FORENSIC USE ONLY

Assay Principle Neogen’s competitive direct ELISAs operate on the basis of competition coated microplate. After the incubation, the microplate is washed and K-Blue® between the drug or its metabolite in the sample and the drug-enzyme Substrate (TMB) is added. After the substrate incubation, the test can be read conjugate for a limited number of specific binding sites on the precoated visually or with a microplate reader. The extent of color development is inversely microplate. proportional to the amount of drug in the sample or control/calibrator. The The simple assay procedure includes the addition of samples, calibrators absence of the drug in the sample will result in a blue color (yellow if acid stop or controls to the antibody-coated microplate followed by the addition of is used), whereas the presence of the drug will result in decreased or no color the enzyme conjugate (HRP). During incubation, the drug in the sample development. and the drug enzyme conjugate compete for binding sites on the antibody-

6 To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com Reagents

Neogen recognizes that additional substrates and reagents may be required for your application. Therefore, Neogen makes available the following products that are optimized with our test kits.

Reagents for Immunoassays Product Shelf Life Product Features Available Sizes Product Number Enhanced K-Blue® 48 months when • Develops blue color in the presence of HRP • 200 mL 308175 stored at 4°C • RTU (ready-to-use) • 500 mL 308176 • Low background • 1 L 308177 • High consistency between lots

Red Stop Solution 24 months when • Produces a dark purple-pink color for a minimum of • 200 mL 301474 stored at 4°C 2 hours when added to the wells • 500 mL 301475 • Non-acidic solution • 1 L 301476 • RTU (ready-to-use)

EIA Buffer 12 months when • Dilutes enzyme conjugates, standards and samples • 500 mL 301276 stored at 4°C • RTU (ready-to-use) • 1 L 301277

Wash Buffer 12 months when • Washes all unbound enzyme conjugate, samples and • 500 mL 301176 stored at 4°C standards from microplates • 1 L 301177 • Concentrated (10x) buffer

ß-Glucuronidase 6 months when • Allows for better detection of total Lorazepam with Neogen’s • Single Reagent 301605 Reagent Pack Reagent A is stored Benzodiazepine Group (Oxazepam/Clonazepam) Kit Pack at 4°C and Reagent B is stored at -20°C

NeoSal Buffer 18 months when • Designed to stabilize oral fluid specimens following collection • 500 mL 120176 stored at room and during transit, it can also be used to dilute additional oral • 1L 120177 temperature fluid samples in preparation for immunoassay. (15–25°C)

Assay Procedure

Wash Well Conjugate Substrate Unbound drug Bound drug Antibodies and drug and drug conjugate conjugate More Less Sample Analyte Analyte drug

Plates are precoated A sample or control is Wash the plate to The bound materials Add TMB substrate to Qualitative results are with the antibody. The added to each well. remove all unbound now remain in the each well and allow the obtained by measuring plate is ready for use. Next, the drug-enzyme materials. microplate. color to develop. the absorbance reading DO NOT WASH. conjugate is added and at 450 nm or 650 nm if the mixture is incubated no acid stop is used. at room temperature.

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com 7 Automated Equipment

Dynex Equipment Hamilton Equipment The DSX Automated Four-Plate ELISA System and the DS2 Automated The Microlab STAR line of workstations was developed based on Two-Plate ELISA System were developed for small to medium-throughput 50 years of expertise in liquid handling for fast and efficient assay processing of ELISAs with advanced automation and precise liquid- automation and sample preparation. These innovative instruments handling capabilities. Neogen’s specially-designed Single Line Reporting were specifically designed for regulated laboratories to ensure full Software enhances the DSX Revelation and DS2 Matrix software’s GMP-compliant operation. reporting capabilities. The Microlab STAR automated liquid handling platform features: The DSX and DS2 automated processing systems feature: • High throughput processing Modular Design • Advanced pipetting technology • Flexible configuration, simple upgrades, and quick module replacement • Easy-to-use VENUS software • Flexible design to allow easy instrument configuration Process Security • Broad range of testing applications • Instrument self-diagnostics supports unmanned operation • Cover lock protects reagents and prevents interference In addition to the Microlab STAR workstation Neogen offers the STARlet (medium - large volume sample lab) and the NIMBUS (small - medium Ease of Use volume sample lab) automated work stations. • Quick and easy installation, user-friendly control system, and minimal maintenance required Excellent Performance • Precise liquid handling capability eliminates variations

Direct Purchase and Reagent Rental Program Neogen offers a full line of Dynex and Hamilton automated equipment for The Reagent Rental Program has proven to be a successful way for many use with our ELISA test kits. The equipment is available for direct purchase of our customers to meet their automation requirements, while at the same or through our Reagent Rental Program, which provides laboratories access time satisfying their ELISA test kit needs. to automation with a lower initial investment. For assistance in determining your exact needs and selecting the best To take advantage of the Reagent Rental Program, customers agree to automated solution for your unique situation, or more details regarding the purchase a predetermined volume of test kits per year from Neogen, based Reagent Rental Program, contact a Neogen sales representative. on number of samples and required drug panel. Once an agreement is reached, Neogen will provide the automated equipment to the customer as a rental. The agreement is structured so the cost of the equipment rental, service contracts and test kits are merged, and spread over the duration of the agreement.

8 To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com Neogen ELISA Drug Detection Cross-reactivity Data

6-AM #134019 4-Fluoroamphetamine 13% Benzylpiperazine #108319 Fentanil Group #100519 6-Acetylmorphine 100% l-Amphetamine 7% Benzylpiperazine 100% Alfentanil 100% 0.6% 6% 1-(3-Trifluoromethyl)benzyl) 3% Sufentanil 270% 0.04% 6% 1-(4-Trifluoromethyl)benzyl) piperazine 1% Norsufentanil 119% 0.04% meta-Chlorophenylpiperazine (mCPP) 6% Trazodone 1% Carfentanil 88% 0.03% Isoxsuprine 4% 0.20% 76% 2% 0.13% Fentanyl 2% Acetaminophen #132419 1% 0.07% Thienylfentanyl 1% Acetaminophen 100% R(+)-Methcathinone 1% m-CPP 0.07% α-Methylfentanyl 0.77% Procainamide 2% (+/-)-MDMA 1% Isoxuprine 0.05% p-Fluorofentanyl 0.19% Ethyl p-aminobenzoate 1% (+/-)- 1% Pyrantel 0.03% 3-Methylfentanyl 0.08% Oxyphenbutazone 0.7% Fencamfamine 1% N-[3-(Trifluoromethyl)phenyl] piperazine 0.03% Norfentanyl 0.04% Penicillin G-Procaine 0.3% α-Ethyltryptamine 0.8% 0.02% Procaine 0.1% S(-)-Methcathinone 0.7% Acepromazine 0.02% Fentanyl #131519 0.09% S(-)- 0.6% 0.01% Fentanyl 100% 2-Aminoheptane 0.6% 0.01% p-Fluorofentanyl 136% Amphetamine #105219-1 Butyryl Fentanyl 96% d-Amphetamine 100% Ampedramoff 0.6% 0.01% 0.5% Thienylfentanyl 67% 1578% Buprenorphine #131919 3-Methylfentanyl 50% d-Methamphetamine 1000% p-Hydroxyamphetamine 0.5% 0.4% Buprenorphine 100% Acetyl Fentanyl 42% N-desmethylselegiline 203% Diprenorphine 110% α-Methylfentanyl 11% Hydroxy 177% (+/-)MDA 0.4% 0.4% Norbuprenorphine 15% Carfentanil 6% 87% Etorphine 0.22% Despropionylfentanyl 0.61% 56% DOM 0.3% Clenbuterol 0.3% Butorphanol 0.16% Lofenanil 0.20% Nylidrin 21% Naltrexone 0.05% Sufentanil 0.15% l-Amphetamine 17% Metaraminol 0.2% p-Methoxymethamphetamine 0.2% 0.02% Norfentanyl 0.01% Mephentermine 14% 0.02% Phentermine 11% 0.2% Fexofenadine/Terfenadine #181419 Phenethylamine 10% p-Methyoxyamphetamine 0.1% Carisoprodol #132519 DOB 0.1% Fexofenadine 100% Benzphetamine 8% Carisoprodol 100% Terfenadine 23% Phenylpropanolamine 6% 0.06% 0.04% Hydroxyzine 0.97% Isoxsuprine 6% Celecoxib #180719 Orphenadrine 0.20% 0.03% Celecoxib 100% MDMA (3,4-methylenedioxymeth-amphetamine) Cetirizine 0.18% Pyrimethamine 0.03% Celecoxib Carboxylic Acid 143% 2% Hydroxyebastine 0.13% 0.03% Deracoxib 56% Pseudoephedrine 2% Carebastine 0.07% Clenbuterol 2% Nicotine 0.02% Amitryptyline 0.02% Citalopram #132719 Doxepin 0.04% Fencamfamine 2% Citalopram 100% Amitryptyline 0.03% α-Ethyltryptamine 1% Quinidine 0.02% Imipramine 0.01% N-desmethylcitalopram 109% Imipramine 0.03% 4-Hydroxyamphetamine 0.6% (S)-Citalopram 20% 0.03% p-Hydroxymethamphetamine 0.5% Nortriptyline 0.01% (+/-) 0.01% Acepromazine 2% Promazine 0.03% 0.5% Chlorpromazine 0.7% Chlorpromazine 0.02% MDA (3,4-methylenedioxy-amphetamine) 0.4% Barbiturate Group #130619 Fluoxetine 0.1% Ebastine 0.02% 0.4% Secobarbital 100% Imipramine 0.07% 0.01% Amfepramone 0.20% Amobarbital 757% Amitriptyline 0.03% Bupropion 0.19% Phenobarbital 469% Paroxetine 0.03% Flunitrazepam #109519 Flunitrazepam 100% DOB 0.12% p-OH Phenobarbital 316% Doxepin 0.03% 7-Aminoflunitrazepam 212% DOM 0.11% Barbital 239% Trimipramine 0.03% 69% Amitriptyline 0.06% Butabarbital 131% Nortriptyline 0.02% Clobazam 3% Quinidine 0.06% Allobarbital 117% Fluvoxamine 0.02% Clonazepam 2% 0.03% Butalbital 109% Promazine 0.02% Midazolam Maleate 1% Imipramine 0.02% Aprobarbital 98% Orphenadrine 0.01% 7-Aminoclonazepam 0.6% Glutethimide 0.01% Pentobarbital 95% Sertraline 0.01% N-Desmethylflunitrazepam 0.5% Nortriptyline 0.01% Mephobarbital 0.3% Duloxetine 0.01% (+/-) 0.01% Methylene Blue 0.1% Halazepam 0.4% Diethylpropion <0.5% Glutethamide 0.1% Cocaine/Benzoylecgonine #130319 Triazolam 0.3% Hordenine <0.1% Benzoylecgonine 100% Nitrazepam 0.3% Pyrantel <0.1% Benzodiazepine Group Cocaine 133% Nordiazepam 0.2% (Oxazepam/Clonazepam) #130119 124% Methylene Blue 0.02% Amphetamine Specific-2 #132319-2 Oxazepam 100% m-Hydroxycocaine 96% Trimipramine 0.01% d-Amphetamine 100% Ecgonine 0.4% (±)-MDA 100% Diazepam 434% Fluoxetine #107619 Estazolam 365% 0.3% Fluoxetine 100% p-Methoxyamphetamine 91% Ecgonine Methyl Ester 0.06% Phentermine 35% Nordiazepam 361% Norfluoxetine 67% p-Hydroxyamphetamine 33% Alprazolam 346% Tetrazepam 264% Cotinine CT-96-U Haloperidol Metabolites #102119 α-Ethyltryptamine 19% (-) Cotinine 100% Haloperidol Metabolite (II) ((+(-)-4- 4-Fluoroamphetamine 16% Flurazepam 262% Lormetazepam 231% (+/-) Trans-3’-hydroxycotinine 3% (4-chlorophenyl)-α-(4-fluorophenyl)-4- l-Amphetamine 1.4% (R/S) Norcotinine 0.89% hydroxy-1-piperidinebutanol) 100% Phenethylamine 0.7% Prazepam 198% Temazepam 192% Cotinine CT-96-S 157% Mephentermine 0.6% Haloperidol 84% 2-Phenylethylamine 0.6% Phenazepam 190% (-) Cotinine 100% Halazepam 173% (+/-) Trans-3’-hydroxycotinine 9% Haloperidol Metabolite (I) (4-(4-chlorophenyl) p-Methoxymethamphetamine 0.5% -4-hydroxypiperidine) 48% (±)-MDMA 0.4% Triazolam 171% (R/S) Norcotinine 2% 7-amino-Flunitrazepam 147% Azaperone 0.002% Dimethoxybromoamphetamine(DOB) 0.1% Detomidine #181319 d-Methamphetamine 0.1% Diclazepam 142% Nitrazepam 141% Detomidine 100% Hydrochlorothiazide #180319 Metaraminol < 0.06% Carboxydetomidine 74% Hydrochlorothiazide 100% Phenylpropanolamine < 0.06% Flubromazepam 120% N-desmethyl Flunitrazepam 119% 26% Trichlormethiazide 206% 1R,2S(-) Ephedrine < 0.06% Chlorothiazide 8% S,S(+) Pseudoephedrine < 0.06% Delorazepam 115% Flunitrazepam 110% Dextromethorphan #131419 Furosemide 0.24% (+) N,N-Diethylnorephedrine < 0.06% Dextromethorphan 100% Methylene Blue 0.01% (N-ethylnorephedrine) < 0.06% Pyrazolam 106% 3-Methoxymorphinan 118% (±) N-Ethylcathinone Ephedrine < 0.06% Etizolam 87% 3-Hydroxymorphinan 2% Hydromorphone #132219 Diethylpropion (Amfepramone) < 0.06% Bromazepam 85% Dextrorphan 2% Hydromorphone 100% Clonazepam 79% Promazine 0.05% 6-Acetylcodeine 143% Amphetamine Ultra #130819 Nimetazepam 74% Trimipramine 0.04% Morphine 85% d-Amphetamine 100% Lorazepam 70% Orphenadrine 0.04% Hydrocodone 72% N-desmethylselegiline 906% Midazolam 65% Imipramine 0.02% 56% Fenproporex 731% Clobazam 59% Nortriptyline 0.02% 55% d-Methamphetamine 688% 7-amino-Clonazepam 39% Amitriptyline 0.02% 54% (-)-Ephedrine 49% alpha-hydroxy Alprazolam 25% Acepromazine 0.01% Levorphanol 49% Fenfluramine 33% Chlordiazepoxide 19% Meperidine 0.01% 6-Acetylmorphine 44% Mephentermine 25% Nylidrin 14%

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com 9 Neogen ELISA Drug Detection Cross-reactivity Data

Morphine-6-glucuronide 39% Meprobamate #133419 Oxycodone/Oxymorphone #130719 MAM 2201 132% 38% Meprobamate 100% Oxycodone 100% JWH-018 6-hydroxyindole 126% Heroin 29% Meprobamate-N-ß-Glucuronide 376% Oxymorphone 88% AM 694 109% Thebaine 2% Carisoprodol 41% Hydrocodone 27% JWH-019 94% Levallorphan 0.5% Hydromorphone 21% JWH-015 83% Morphine-3-glucuronide 0.4% Methamphetamine/MDMA #130919 Ethylmorphine 7% JWH-018 4-hydroxyindole metabolite 60% Oxymorphone 0.3% d-Methamphetamine 100% Codeine 5% JWH-122 51% Oxycodone 0.2% PMMA (p-Methoxymethamphetamine) 1400% Thebaine 3% THJ-2201 51% Nalorphine 0.1% MDMA (3,4-Methylenedioxymethamphetamine) 6-Acetylcodeine 3% JWH-018 5-hydroxyindole metabolite 50% 0.1% 212% 3% AM-2201 6-hydroxyindole metabolite 50% Norcodeine 0.04% p-Hydroxymethamphetamine 77% 6-Acetylmorphine 2% JWH-007 34% Meperidine 0.02% l-Methamphetamine 69% Levorphanol 2% JWH-398 13% Dextromethorphan 0.02% MDEA (Methylenedioxyethylamphetamine) 54% Heroin 2% THJ-018 13% Amitriptylline 0.01% Mephentermine 13% Morphine 1% WIN 55,212-3 mesylate 11% Doxepin 0.01% 8% 0.2% JWH-081 6% Fenfluramine 7% Meperidine 0.03% JWH-210 5% Ibuprofen #180219 N-desmethyselegiline 7% JWH-250 N-(5-carboxypentyl) metabolite 2% Ibuprofen 100% PMA (p-Methoxyamphetamine) 4% Pentazocine #103119 JWH-250 N-(5-hydroxypentyl) metabolite 1% 0.3% Ephedrine 3% Pentazocine 100% JWH-250 N-(4-hydroxypentyl) metabolite 1% Fenoprofen 0.06% 4-Fluoroamphetamine 2% Carfentanil 0.01% RCS-4 N-(5-hydroxypentyl) metabolite 0.7% Indoprofen 0.02% Mephedrone 2% JWH-203 0.50% Suprofen 0.01% MDA (3,4-Methylenedioxyamphetamine) 2% Phencyclidine (PCP) #130519 Phencyclidine 100% JWH-250 0.50% Pseudoephendrine 1% Ketamine #131719 4-Hydroxyphencyclidine 2% RCS-4 0.4% 4-Hydroxyamphetamine 0.6% Ketamine 100% 0.18% RCS-8 0.3% d-Amphetamine 0.6% 5% Cyclobenzaprine 0.12% PB-22 N-(5-hydroxypentyl) metabolite 0.2% Phenethylamine 0.5% 0.08% Orphenadrine 0.04% PB-22 N-pentanoic acid 0.12% −Ethyltryptamine 0.2% α Amitriptyline 0.03% 5-fluoro PB-22 0.11% (+/-) Synephrine 0.2% LSD #130219 Promazine 0.03% PB-22 N-(4-hydroxypentyl) metabolite 0.11% Phentermine 0.2% LSD 100% Nortriptyline 0.02% PB-22 0.06% Hordenine 0.2% LAMPA 153% Chlorpromazine 0.02% BB-22 0.03% Methylhexanamine 0.1% Fentanyl 56% Imipramine 0.02% Nortriptyline 0.1% Synthetic Cannabinoids (JWH-250) Nor-/Nor-iso-LSD 36% Doxepin 0.01% PPA (Phenylpropanolamine) 0.1% Acetyl Fentanyl 13% Methoxetamine 0.01% #133719 Hydroxy Bupropion 0.04% Iso-LSD 3% Methylene Blue 0.01% JWH-250 100% Penicillin G-Procaine 0.04% 2-oxo-3-OH LSD 2% Trimipramine 0.01% JWH-250 N-(5-carboxypentyl) metabolite 160% Fenproporex 0.04% 2-oxo-3-OH LAMPA 1% Acepromazine 0.01% JWH-250 N-(5-hydroxypentyl) metabolite 158% 0.08% Procaine 0.02% JWH-250 N-(4-hydroxypentyl) metabolite 123% Clenbuterol 0.07% Doxepin 0.01% Phenytoin #132119 JWH-073 N-(4-hydroxybutyl) metabolite 107% Methylene Blue 0.06% Phenytoin 100% JWH-018 N-(5-hydroxypentyl) metabolite 104% Procaineamide 0.02% Methylphenidate #133219 Hydroxyphenytoin 61% JWH-073 94% Methylphenidate 100% (+)-JWH-018 N-(4-hydroxypentyl) metabolite 90% Meperidine #131219 133119 Ritalinc Acid 0.53% Propoxyphene #131119 AM 2232 90% Meperidine 100% Naltrexone/Nalbuphine #133019 Propoxyphene 100% AM 1220 86% Normeperidine 5% 30% JWH-200 84% Anileridine 2% Naltrexone 100% Nalbuphine 202% Salicylates #133619 JWH-203 76% 41% 100% JWH-018 N-pentanoic acid 64% Meprobamate #133419 JWH-018 N-(5-hydroxypentyl) ß-D-glucuronide 59% Meprobamate 100% Butorphanol 28% 4-aminosalicylic Acid 121% 26% 52% JWH-015 59% Meprobamate-N-ß-Glucuronide 376% JWH-250 5-hydroxyindole metabolite 55% Carisoprodol 41% 6ß-Naltrexol 7% Gentisic Acid 37% 3-Methoxynaltrexone 6% Salicyluric Acid (2-Hydroxyhippuric Acid) 2% AM 2201 54% 0.1 JWH-073 N-butanoic acid metabolite 53% Methadone #131619 4% Nalorphine 1% Sertraline #131319 JWH-022 47% Methadone 100% Sertraline 100% JWH-018 33% LAAM 113% Pentazocine 0.3% Codeine 0.02% N-Desmethylsertraline 50% AM 2201 6-hydroxyindole metabolite 33% 0.06% Methylene Blue 4% RCS-8 33% Trimeprazine 0.04% Opiate Group #130419 Fluoxetine 0.7% MAM 2201 30% 0.04% Morphine 100% Pyrilamine 0.4% THJ-2201 24% EDDP 0.03% 6-Acetylcodeine 195% Paroxetine 0.3% PB-22 N-(5-hydroxypentyl) metabolite 23% Trimipramine 0.02% Codeine 190% Promazine 0.2% JWH-018 6-hydroxyindole metabolite 21% Imipramine 0.01% Morphine-3-Glucuronide 154% Chlorpromazine 0.2% 5-fluoro PB-22 19% Orphenadrine 0.01% Heroin/Diacetylmorphine 154% Amitriptyline 0.2% PB-22 N-(4-hydroxypentyl) metabolite 19% Acepromazine 0.01% 6-Acetylmorphine 146% Acepromazine 0.2% 1’ Napthoyl Indole 18% Amitriptyline 0.01% Hydrocodone 122% Nortriptyline 0.2% JWH-018 5-hydroxyindole metabolite 16% 0.01% Ethylmorphine 110% Doxepin 0.1% PB-22 N-pentanoic acid 14% Promazine 0.01% Nalorphine 76% Pyrethamine 0.1% JWH-019 14% Chlorpromazine 0.01% Hydromorphone 66% Trimipramine 0.1% THJ-018 13% Methotrimeprazine 0.01% Morphine-6-Glucuronide 37% Imipramine 0.1% JWH-007 11% Methadone/LAAM #132919 22% 0.02% PB-22 11% Methadone 100% Thebaine 11% JWH-018 4-hydroxyindole metabolite 10% LAAM 107% Levallorphan 7% Synthetic Cannabinoids (JWH-018) JWH-122 10% Dextromethorphan 0.18% Naloxone 2% #133519 (+) WIN 55212-2 (mesylate) 8% Promethazine 0.15% Oxycodone 2% JWH-018 100% JWH-081 7% Trimeprazine 0.11% Levorphanol 2% JWH-073-N-(4-hydroxybutyl) metabolite 980% BB-22 6% Trimipramine 0.09% Oxymorphone 1% JWH-018 N-5-hydroxypentyl 754% AM 2201 N-(4-hydroxypentyl) metabolite 6% EDDP 0.04% Imipramine 0.4% JWH-200 613% JWH-398 4% Promazine 0.04% Norcodeine 0.3% JWH-018- N-pentanoic acid 613% JWH-210 1% Propiomazine 0.03% Trimipramine 0.3% JWH-073 490% AM 694 1% Acepromazine 0.03% Rifampicin 0.22% AM 2232 446% RCS-4 N-(5-hydroxypentyl) metabolite 0.8% Chlorpromazine 0.03% Normorphine 0.2% JWH-073 N-butanoic acid 426% RCS-4 0.7% Imipramine 0.02% Naltrexone 0.2% (±) JWH-018-N-(4-hydroxypentyl) metabolite 392% XLR11 N-(4-hydroxybutyl) metabolite 0.01% Doxepin 0.02% Acepromazine 0.05% AM 2201 350% Orphenadrine 0.02% Levofloxacin 0.05% AM 1220 288% Amitriptyline 0.02% Meperidine 0.02% JWH-022 233% Prochlorperazine 0.01% Chlorpromazine 0.02% AM-2201 N-(4-hydroxypentyl) metabolite 166% Methotrimeprazine 0.01% Promazine 0.01% 1’-Naphthoyl Indole 153% Meperidine 0.01% JWH-018 N-(5-hydroxypentyl) ß-D-glucuronide 136%

10 To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com Neogen ELISA Drug Detection Cross-reactivity Data

Synthetic Cannabinoids (UR-144/XLR-11) Tricyclics Group #132019 Methoxyphenamine 0.5% Methoxyphenamine 0.3% #133919 Imipramine 100% (+) Pseudoephedrine 0.5% (-) Amphetamine 0.2% UR-144 N-pentanoic acid 100% Amitriptyline 464% Phentermine 0.1% 1S,2R (+) Ephedrine <1.3% A-796260 89% Doxepin 364% Nicotine 0.1% 4-Fluoroamphetamine HCl <1.01% UR-144 N-(5-hydroxypentyl) metabolite 89% Cyclobenzaprine 315% R (+) Methcathinone 0.1% (+) Amphetamine <0.1% (±)-UR-144 N-(4-hydroxypentyl) metabolite 62% Dothiepin 232% <0.1% Nortriptyline 155% Opiates Oral Fluid #120319 Phenylpropanolamine <0.1% XLR-11 45% Morphine 100% A-834735 36% 143% R,R (-) Pseudoephedrine <0.1% Protriptyline 44% Ethylmorphine 162% Phendimetrazine <0.1% XLR11 N-(4-pentenyl) analog 20% Codeine 136% UR-144 18% Trimipramine 44% R (+) Methcathinone <0.1% Promazine 21% 6-Acetylcodeine 103% Phentermine <0.1% UR-144 N-(2-hydroxypentyl) metabolite 11% 6-Acetylmorphine 86% XLR-11 N-(4-hydroxypentyl) metabolite 7% Chlorpromazine 20% R ( +) Cathinone <0.1% Desipramine 12% Heroin/Diacetylmorphine 86% Labetalol <0.1% XLR11 Degradant 6% Dihydrocodeine 39% UR-144 Degradant 2% 9% (-) Phenylephrine <0.1% Prochlorperazine 8% Morphine-6-β-D-Glucuronide 35% (+/-) 2,5-Dimethoxy-4-bromoamphetamine <0.1% STS-135 (RM) 0.44% Dihydromorphine 28% AKB48 N-(5-fluoropentyl) metabolite 0.33% 4% Morphine-3-β-D-Glucuronide 25% AKB48 0.18% Maprotiline 4% Opiates Hair #140319 3% Thebaine 23% Morphine 100% JWH-250 N-(5-hydroxypentyl) metabolite 0.1% Hydrocodone 17% JWH-203 0.08% Fluphenazine 3% Dihydrocodeine 243% 3% Hydromorphone 12% Heroin 142% JWH-250 N-(5-carboxypentyl) metabolite 0.07% Levorphanol 5% JWH-250 N-(4-hydroxypentyl) metabolite 0.07% 2% Codeine 121% Orphenadrine 2% Nalorphine 4% 6-Acetylmorphine 85% JWH-250 0.04% Oxymorphone 0.2% AM 694 0.03% 0.7% Morphine-6-Glucuronide 8% Acepromazine 0.6% Oxycodone 0.2% Morphine-3-Glucuronide 8% RCS-8 0.02% Norcodeine 0.2% AM 1220 0.02% 0.5% Hydrocodone 5% 0.4% Meperidine 0.1% Hydromorphone 3% JWH-200 0.01% Diprenorphine 0.1% JWH-073 0.01% 0.2% Oxycodone 0.06% Propionylpromazine 0.1% Normorphine 0.1% Oxymorphone 0.04% AM 2232 0.01% Norbuprenorphine <0.4% JWH-073 N-(4-hydroxybutyl) metabolite 0.01% 0.05% 0.04% Buprenorphine <0.4% Synthetic Opiates Hair #140419 JWH-018 N-(5-hydroxypentyl) metabolite 0.01% Noroxymorphone <0.4% Oxycodone 100% Thiothixene 0.04% Hydrocodone 120% Synthetic Cathinones (Methcathinone) Glycopyrrolate 0.02% PCP Oral Fluid #120419 #181819 Oxymorphone 20% 0.02% PCP 100% Dihydrocodeine 12% R(+) Methcathinone 100% Hydroxyzine 0.02% Metaphit 200% Mephedrone 167% 6-Acetylcodeine 8% Trazodone 0.01% 4-Methoxy PCP (hydrochloride) 100% Codeine 7% 150% Pyrilamine 0.01% PCPr (hydrochloride) 4% 120% Ethylmorphine 6% Pyrimethamine 0.01% PCP morpholine 3% Hydromorphone 5% 103% 4-Hydroxy PCP 0.2% 4-Fluoromethcathinone () 94% Zolpidem #132619 Heroin 2% Zolpidem 100% PCMPA (hydrochloride) 0.2% Dihydromorphine 2% 3-Fluoromethcathinone 75% Furosemide 0.03% (±) Methcathinone 73% Carboxy-Zolpidem 0.02% Levorphanol 2% Promazine 0.02% 6-Acetylmorphine 2% (bk-MDEA) 43% Acepromazine 0.02% Ethcathinone 40% Zopiclone/Eszopiclone #133819 Morphine 1% 4-Methylethcathinone 35% Zopiclone 100% THC Oral Fluid #120519 Noroxycodone 1% 2% Zopiclone-N-Oxide 100% (-) ∆9-THC 100% Thebaine 0.8% 1% N-Desmethyl-Eszopiclone 350% 11-nor-9-carboxy- ∆8-THC 252% Morphine-3-glucuronide 0.2% R(+) Cathinone 0.43% Eszopiclone 194% (+/-) 11-hydroxy-∆9-THC 146% Naloxone 0.1% S(+) Methamphetamine 0.088% 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy (-) 11-nor-9-carboxy- ∆9-THC 138% Morphine-6-glucuronide <1.5% (±) MBDB (Butylone) 0.055% -5H-pyrrolo[3,4b]pyrazin-5-one 0.4% (+/-) 11-nor-9-carboxy- ∆9-THC 87% Norbuprenorphine <1.5% (-)-(S)-Cathinone 0.050% Zaleplon <0.04% (-) ∆8-THC 62% Buprenorphine <1.5% 1R,2S(-) Ephedrine 0.043% Zolpidem <0.04% Cannabinol 22% Noroxymorphone <1.5% 1S,2R(+) Ephedrine 0.012% Nalorphine <0.2% Diethylpropion 0.006% Oral Fluid Kits Normorphine <0.2% (±) N-Ethylcathinone ephedrine 0.006% Hair Kits Diprenorphine <0.2% Dextromethorphan <0.2% R,R(-) Pseudoephedrine 0.005% Cocaine Oral Fluid #120119 Cocaine Hair #140119 MDPV < 0.003% Benzoylecgonine 100% Naltrexone <0.2% m-Hydroxybenzoylecgonine 140% Cocaine 100% Naltriben <0.2% PVP < 0.003% Benzoylecgonine isopropyl ester 167% (±) MDA < 0.003% Cocaethylene 59% Nalmefene <0.2% Cocaine 58% Cocaethylene 133% Apomorphine <0.2% R(-) Amphetamine < 0.003% Benzoylecgonine 83% (+) Norpseudoephedrine < 0.003% Tropacocaine 4% 3-Methoxy-naltrexone <0.2% Ecgonine 1% Meta-Hydroxybenzoylecgonine 71% (+)-N,N-Diethylnorephedrine < 0.003% Ecgonine 0.6% (±) Phenylpropanolamine < 0.003% Norbenzoylecgonine 0.5% PCP Hair #140519 Ecgonine methyl ester 0.5% Norbenzoylecgonine 0.3% Phencyclidine 100% < 0.003% Norcocaine 0.2% Metaphit 60% S,S(+)-Pseudoephedrine < 0.003% Methylene Blue 0.3% Anhydroecgonine methyl ester 0.2% Norcocaethylene 0.2% Phencyclidine Morpholine 20% THC #131019 Norcocaine 0.2% Ecgonine methyl ester <0.1% 4-Hydroxy-Phencyclidine 5% ∆9-THC-COOH 100% Anhydroecgonine methyl ester <0.1% 8 Anhydroecgonine <0.1% THC Hair #140619 ∆ -THC-COOH 88% Methamphetamine Oral Fluid #120219 9 9 Atropine <0.1% ∆ -THC 100% 11-OH-∆ -THC 13% S (+) Methamphetamine 100% 9 8 (-)-11-nor-∆ -THC-9-COOH 417% ∆ -THC 5% PMMA (p-Methoxymethamphetamine) 367% 9 ∆9-THC 4% (+/-) MDMA (3,4,-Methylene-dioxymethamphet- Methamphetamine Hair #140219 (-)-11-nor-∆ -THC-9-COOH-glucuronide 313% (+/-) MDMA 100% 8 Cannabinol 2% ) 97% (-)-11-nor-∆ -THC-9-COOH 167% PMMA 250% (+/-)-11-nor-∆9-THC-9-COOH 125% 0.01% p-Hydroxymethamphetamine 52% 9 (+/-) MBDB (1,3-Benzodioxolyl-N-methylbutana- S (+) Methamphetamine 53% (+/-)-11-Hydroxy-∆ -THC 100% Tramadol #131819 (+/-) MBDB 33% Cannabinol 71% mine) 43% 8 Tramadol 100% (+/-) MDEA (Methylenedioxyethylamphetamine) 9% p-Hydroxymethamphetamine 33% ∆ -THC 71% O-Desmethyl Tramadol 22% Mephentermine 5% (+/-) MDEA 17% Cannabidiol 0.17% N-Desmethyl Tramadol 7% (+/-) HMMA (4-hydroxy-3-methoxymandelic Mephentermine 7% N,N-Bisdesmethyl Tramadol 5% acid) 4% (+/-) 4-Hydroxyephedrine 5% 1R,2S (-) Ephedrine 3% Trazodone #132819 PMA (p-Methoxyamphetamine) 3% Hydroxyephedrine 2% (-) Methamphetamine 3% Trazodone 100% (+/-) HMMA 2% Nefazodone 20% 1R, 2S (-)Ephedrine 2% R (-) Methamphetamine 2% PMA 2% m-CPP 0.7% (+/-) MDA 0.8% N-(3-(Trifluoromethyl)phenyl)piperazine 0.3% (+/-) MDA (3,4-Methylenedioxyamphetamine) 0.9% (+) Amphetamine 0.6% Fenfluramine 0.6% 1-(3-(Trifluoromethyl)benzyl)piperazine 0.2% (+) Pseudoephedrine 0.6% Doxepin 0.1% Fenfluramine 0.5% 1-(4-(Trifluoromethyl)benzyl)piperazine 0.07% Hordenine 0.5% Acepromazine 0.01% Imipramine 0.01%

To order, call: 800-477-8201 (USA/Canada) or 859-254-1221 • Fax: 859-255-5532 • E-mail: [email protected] • Web: toxicology.neogen.com 11 References V. Spiehler, D. Isenschmid, P. Mathews, P. Kemp, T. Kupiec. Performance of a Microtiter Plate ELISA for Screening of Postmortem Blood for Cocaine and Metabolites. J. Analytical Toxicol. 27:587–591 (2003). V. Spiehler, L. DeCicco, R. McCutcheon, T. Kupiec, P. Kemp. Screening Postmortem Whole Blood for Oxycodone by ELISA Response Ratios. J. Forensic Sci. 49, No. 3:621–626 (2004). T. Kupiec, L. DeCicco, V. Spiehler, G. Sneed, P. Kemp. Choice of an ELISA Assay for Screening Postmortem Blood for Amphetamine and/or Methamphetamine. J. Analytical Toxicol. 26:513–518 (2002). P. Kemp, G. Sneed, T. Kupiec, V. Spiehler. Validation of a Microtiter Plate ELISA for Screening of Postmortem Blood for Opiates and Benzodiazepines. J. Analytical Toxicol. 26:504–512 (2002). H.R. Wallage and J-P.F.P. Palmentier. Hydromorphone-Related Fatalities in Ontario. J. Analytical Toxicol. 30:202–209 (2006). N. Harun, R.A. Anderson, E.I. Miller. Validation of an Enzyme-Linked Immunosorbent Assay Screening Method and a Liquid Chromatography-Tandem Mass Spectrometry Confirmation Method for the Identification and Quantification of Ketamine and Norketamine in Urine Samples from Malaysia. J. Analytical Toxicol. 33:310–321 (2009). Negrusz, P. Adamowicz, B.K. Saini, D.E. Webster, M.P. Juhascik, C.M. Moore, R.F. Schlemmer. Detection of Ketamine and Norketamine in Urine of Nonhuman Primates after a Single Dose of Ketamine using Microplate Enzyme-Linked Immunosorbent Assay (ELISA) and NCI-GC-MS. J. Analytical Toxicol. 29:163-168 (2005). Brzenski AB, Phan J, Yaksh TL, Rossi SS, Benumof JL (2013) Intravenously Administered Fentanyl is Not Detectable in Exhaled Breath. Analg Resusc: Curr Res 2:1. doi:10.4172/2324-903X.1000104 L. Reidy, B. Nolan, A.R. Ramos, H.C. Walls, B.W. Steele. Zolpidem Urine Excretion Profiles and Cross-Reactivity with ELISA Kits in Subjects Using Zolpidem or Ambien® CR as a Prescription Sleep Aid. J. Analytical Toxicol. 35:294-301 (2011). P. Adamowicz, B. Tokarczyk, R. Stanaszek, M. Slopianka. Fatal Mephedrone Intoxication – A Case Report. J. Analytical Toxicol. 37:37-42 (2013). doi:10.1093/jat/bks085 N.B. Tiscione, X. Shan, I. Alford, D.T. Yeatman. Quantitation of in Whole Blood by Electron Impact-Gas Chromatography–Mass Spectrometry. J. Analytical Toxicol. 35:99-107 (2011). Spinelli, Eliani, et al. “Performance characteristics of an ELISA screening assay for urinary synthetic cannabinoids.” Drug testing and analysis 7.6 (2015): 467-474. Tallo-Parra, O., et al. “Hair cortisol detection in dairy cattle by using EIA: protocol validation and correlation with faecal cortisol metabolites.” animal 9.06 (2015): 1059-1064. Spinelli, Eliani, et al. “Performance characteristics of an ELISA screening assay for urinary synthetic cannabinoids.” Drug testing and analysis 7.6 (2015): 467-474. Hagan, Kiara S., and Lisa Reidy. “Detection of synthetic cathinones in victims of sexual assault.” Forensic science international 257 (2015): 71-75. Reisfield, Gary M., and Joseph T. Jones. “The Disposition of Oxycodone and Metabolite in Human Hair.” Journal of analytical toxicology 39.9 (2015): 746-750.

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