Trefoil Factor 3 Overexpression in Prostatic Carcinoma: Prognostic Importance Using Tissue Microarrays Dennis A Faith, William B Isaacs, James D Morgan, Helen L Fedor, Jessica L Hicks, Leslie A Mangold, Patrick C Walsh, Alan W Partin, Elizabeth A. Platz, Jun Luo, and Angelo M De Marzo Brady Urological Institute [D.A.F., J.L.,L.M., P.C.W., A.W.P., W.B.I, A.M.D..], Department of Pathology [J.D.M., H.F., J.H., A.M.D.], The Sidney Kimmel Comprehensive Cancer Center [W.B.I., A.M.D] , The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287; Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205 [E.P.]; Funded by Public Health Services NIH/NCI Specialized Program in Research Excellence (SPORE) in Prostate Cancer #P50CA58236 (Johns Hopkins), The Prostate Cancer Foundation, and by Philanthropic Support from Susan and Donald Sturm Correspondence and Reprint Requests: Angelo M. De Marzo, M.D., Ph.D., Jun Luo, Ph.D. Department of Pathology, Marburg 411 The Johns Hopkins University, Brady Urological Institute CRB 153 The Johns Hopkins University School 1650 Orleans Street, of Medicine Baltimore, MD 21231-1000 600 N. Wolfe St Phone: (410) 614-5686 Baltimore, MD 21287 Fax: (410) 502-9817 E-mail:
[email protected] Funded by Public Health Services NIH/NCI #R01CA084997, NIH/#R01CA70196 and NIH/NCI Specialized Program in Research Excellence (SPORE) in Prostate Cancer #P50CA58236. TFF3 Expression in Prostate Cancer Page 2 ABSTRACT Human intestinal trefoil factor 3 (TFF3) is a member of a family of polypeptides encoded by a cluster of genes on chromosome 21.