Chromosome 21 Leading Edge Set

Genes from chr21q22 that are part of the GSEA leading edge set identifying differences between trisomic and euploid samples. Multiple probe set IDs corresponding to a single gene symbol are combined as part of the GSEA analysis.

Gene Symbol Probe Set IDs Gene Title

203865_s_at, 207999_s_at, 209979_at, adenosine deaminase, RNA-specific, B1 ADARB1 234539_at, 234799_at (RED1 homolog rat) UDP-Gal:betaGlcNAc beta 1,3- B3GALT5 206947_at galactosyltransferase, polypeptide 5 BACE2 217867_x_at, 222446_s_at beta-site APP-cleaving 2

1553227_s_at, 214820_at, 219280_at, 225446_at, 231860_at, 231960_at, bromodomain and WD repeat domain BRWD1 244622_at containing 1 C21orf121 240809_at 21 open reading frame 121 C21orf130 240068_at open reading frame 130 C21orf22 1560881_a_at chromosome 21 open reading frame 22

C21orf29 1552570_at, 1555048_at_at, 1555049_at chromosome 21 open reading frame 29 C21orf33 202217_at, 210667_s_at chromosome 21 open reading frame 33

C21orf45 219004_s_at, 228597_at, 229671_s_at chromosome 21 open reading frame 45

C21orf51 1554430_at, 1554432_x_at, 228239_at chromosome 21 open reading frame 51 C21orf56 223360_at chromosome 21 open reading frame 56 C21orf59 218123_at, 244369_at chromosome 21 open reading frame 59

C21orf66 1555125_at, 218515_at, 221158_at chromosome 21 open reading frame 66 C21orf7 221211_s_at chromosome 21 open reading frame 7 C21orf77 220826_at chromosome 21 open reading frame 77 C21orf84 239968_at, 240589_at chromosome 21 open reading frame 84

1552819_at, C21orf86 226995_at,228908_s_at,228909_at chromosome 21 open reading frame 86 C21orf89 1552876_at, 1552877_s_at chromosome 21 open reading frame 89 C21orf9 1554203_at chromosome 21 open reading frame 9 C21orf90 1554953_a_at, 1554954_at chromosome 21 open reading frame 90 CBR1 209213_at carbonyl reductase 1 chromatin assembly factor 1, subunit B CHAF1B 204775_at (p60) CLDN14 210689_at claudin 14 CLIC6 227742_at, 242913_at chloride intracellular channel 6 CRYAA 210199_at crystallin, alpha A 1552347_at, 1554767_s_at, 1560609_at, CRYZL1 219767_s_at, 226151_x_at crystallin, zeta ( reductase)-like 1 CSTB 201201_at, 236449_at cystatin B (stefin B)

1552677_a_at,1554967_at,1554969_x_at, 1555301_a_at,1556127_at,1561286_a_at, DIP2 disco-interacting 2 homolog A DIP2A 215529_x_at,227199_at (Drosophila) DONSON 221677_s_at downstream neighbor of SON DSCR3 203635_at, 217309_s_at critical region gene 3 DSCR6 207267_s_at Down syndrome critical region gene 6 dual-specificity tyrosine-(Y)-phosphorylation DYRK1A 209033_s_at, 211079_s_at, 211541_s_at regulated kinase 1A phosphoribosylglycinamide formyltransferase, 210005_at,212378_at,212379_at,216990_ phosphoribosylglycinamide synthetase, GART at,217445_s_at,230097_at,244822_at phosphoribosylaminoimidazole synthetase H2BFS 208579_x_at H2B family, member S holocarboxylase synthetase (biotin- (proprionyl-Coenzyme A-carboxylase (ATP- HLCS 207833_s_at, 209399_at hydrolysing)) ligase) high-mobility group nucleosome binding HMGN1 200943_at, 200944_s_at domain 1 204191_at, 225661_at, 225669_at, interferon (alpha, beta and omega) receptor IFNAR1 236478_at 1 interferon (alpha, beta and omega) receptor IFNAR2 204785_x_at, 204786_s_at, 201642_at 2 interferon gamma receptor 2 (interferon IFNGR2 201642_at gamma transducer 1)

207322_at, 209297_at, 209298_s_at, ITSN1 210713_at, 35776_at intersectin 1 (SH3 domain protein) potassium voltage-gated channel, Isk- KCNE1 208514_at, 236407_at, 221095_s_at related family, member 1 potassium voltage-gated channel, Isk- KCNE2 221095_s_at related family, member 2 KRTAP10- 12 237853_x_at keratin associated protein 10-12 KRTAP13- 1 1564921_at keratin associated protein 13-1 KRTAP19- 1 1556410_a_at keratin associated protein 19-1 LOC28483 7 1563088_a_at hypothetical protein LOC284837 LRRC3 221017_s_at leucine rich repeat containing 3 MCM3APA minichromosome maintenance complex S 1560542_at, 220459_at, 232740_at component 3 associated protein antisense myxovirus (influenza virus) resistance 2 MX2 204994_at (mouse) NADH dehydrogenase (ubiquinone) NDUFV3 226209_at, 226616_s_at flavoprotein 3, 10kDa OLIG2 213824_at, 213825_at oligodendrocyte lineage transcription factor 2 PCNT 203660_s_at, 233387_s_at pericentrin PCP4 205549_at protein 4 PDE9A 205593_s_at, 237139_at phosphodiesterase 9A

1566670_at, 202671_s_at, 218018_at, PDXK 218019_s_at, 222492_at, 1566671_a_at pyridoxal (pyridoxine, vitamin B6) kinase PFKL 201102_s_at, 211065_x_at phosphofructokinase, phosphatidylinositol glycan anchor PIGP 221689_s_at biosynthesis, class P

PLAC4 214750_at, 227519_at, 231454_at placenta-specific 4 1555546_a_at, 207448_at, 207449_s_at, POFUT2 209578_s_at protein O-fucosyltransferase 2 PP9284 /// transmembrane protease, serine 2 /// TMPRSS2 226553_at hypothetical protein LOC100130534 230777_s_at, 231931_at, 234524_at, PRDM15 236061_at PR domain containing 15

202098_s_at, 210384_at, 221564_at, PRMT2 228722_at, 228725_x_at protein arginine methyltransferase 2 PWP2H 209336_at periodic tryptophan protein homolog (yeast) receptor-interacting serine-threonine kinase RIPK4 221215_s_at, 234730_s_at 4 RSPH1 /// TSGA2 230093_at radial spoke head 1 homolog

208129_x_at, 209359_x_at, 209360_s_at, 210365_at, 210805_x_at, 211179_at, 211180_x_at, 211181_x_at, 211182_x_at, runt-related transcription factor 1 (acute RUNX1 211620_x_at, 217263_x_at myeloid leukemia 1; aml1 oncogene) SH3 domain binding glutamic acid-rich SH3BGR 204979_s_at protein

SIM2 1557900_at, 206558_at, 208157_at single-minded homolog 2 (Drosophila)

1555952_at, 209775_x_at, 209776_s_at, Solute carrier family 19 (folate transporter), SLC19A1 209777_s_at, 211576_s_at, 229639_s_at member 1 SNF1LK 208078_s_at, 232470_at SNF1-like kinase superoxide dismutase 1, soluble SOD1 200642_at (amyotrophic lateral sclerosis 1 (adult))

201085_s_at, 201086_x_at, 213538_at, SON 214988_s_at, 226465_s_at SON DNA binding protein TFF2 214476_at (spasmolytic protein 1) TFF3 204623_at (intestinal) 1555446_s_at, 208184_s_at, 209412_at, TMEM1 215269_at transmembrane protein 1 TMEM50B 219600_s_at, 222907_x_at, 225182_at transmembrane protein 50B

TMPRSS2 1570433_at, 205102_at, 211689_s_at transmembrane protease, serine 2 transient receptor potential cation channel, TRPM2 205708_s_at subfamily M, member 2

1569472_s_at, 208073_x_at, 208661_s_at, 208662_s_at, 208663_s_at, TTC3 208664_s_at, 210645_s_at tetratricopeptide repeat domain 3 1557053_s_at, 209041_s_at, ubiquitin-conjugating enzyme E2G 2 (UBC7 UBE2G2 209042_s_at, 232755_at homolog, yeast) ZNF295 225539_at, 233952_s_at zinc finger protein 295