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Laboratory Chemical Hygiene Plan

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Laboratory Chemical Hygiene Plan Laboratory Chemical Hygiene Plan Yale University Office of Environmental Health & Safety Office of Environmental Health & OfficeSafety of Environmental Health 135 College Street, Suite 100, New Haven, CT 06510 Telephone: 203-785-3550 / Fax: 203-785-7588 ehs.yale.edu Revised April 2018 CONTENTS SECTION 1.0 YALE UNIVERSITY LABORATORY CHEMICAL HYGIENE PLAN ......... 1 1.1 INTRODUCTION ........................................................................................................... 1 1.2 CHEMICAL HYGIENE RESPONSIBILITIES .............................................................. 1 1.3 DEFINITIONS ................................................................................................................ 3 1.3.1 Laboratory Definition .......................................................................................... 3 1.3.2 Hazardous Chemical Definition .......................................................................... 3 1.4 HAZARD IDENTIFICATION FOR NEWLY SYNTHESIZED CHEMICALS ........... 4 1.5 TRAINING & INFORMATION ..................................................................................... 4 1.5.1 Chemical Safety Training .................................................................................... 4 1.5.2 Chemical Safety Information Sources ................................................................. 5 1.6 CHEMICAL EXPOSURE ASSESSMENT .................................................................... 7 1.7 MEDICAL CONSULTATION & EXAMINATION ...................................................... 7 1.7.1 Medical and Workplace Consultations - Reproductive Toxins ............................. 8 1.8 LABORATORY SAFETY INSPECTION PROGRAM ................................................. 8 1.9 RESEARCH PROTOCOL REVIEW .............................................................................. 8 1.10 RESPIRATORY PROTECTION PROGRAM ............................................................... 9 1.11 RECORDKEEPING ........................................................................................................ 9 SECTION 2.0 STANDARD OPERATING PROCEDURES FOR WORKING WITH HAZARDOUS CHEMICALS ............................................................................... 10 2.1 CHEMICAL HANDLING WORK PRACTICES AND PROCEDURES .................... 10 2.1.1 General Guidelines ............................................................................................ 10 2.1.2 Personal Hygiene ............................................................................................... 11 2.1.3 Housekeeping .................................................................................................... 11 2.1.4 Glassware Safety ............................................................................................... 11 2.2 RISK ASSESSMENT AND REVIEW OF SAFETY PROCEDURES ........................ 11 2.3 PROTECTIVE CLOTHING AND LABORATORY SAFETY EQUIPMENT ........... 12 2.3.1 Standard Laboratory Clothing – Appropriate Attire .......................................... 12 2.3.2 Additional Personal Protective Equipment ........................................................ 13 2.3.3 Gloves ................................................................................................................ 13 2.3.4 Eye Protection .................................................................................................... 14 2.3.5 Protection Of The Respiratory System .............................................................. 14 2.3.5 Laboratory Safety Equipment ............................................................................ 15 2.4 CHEMICAL PROCUREMENT, DISTRIBUTION AND STORAGE ......................... 17 2.4.1 Chemical Management ...................................................................................... 17 2.4.2 Distribution ........................................................................................................ 17 2.4.3 Chemical Storage in the Laboratory .................................................................. 17 2.5 CHEMICAL SPILLS & ACCIDENTS ......................................................................... 19 2.5.1 General Information .......................................................................................... 19 2.5.2 Minor Chemical Spill ........................................................................................ 19 2.5.3 Major Chemical Spill ......................................................................................... 20 2.5.4 Small Mercury Spills ......................................................................................... 20 2.5.5 Alkali Metal Spills ............................................................................................. 20 2.6 PERSONAL CONTAMINATION AND INJURY ....................................................... 20 2.6.1 General Information .......................................................................................... 20 2.6.2 Chemicals Spills to the Body ............................................................................. 21 Yale University Chemical Hygiene Plan Revised April 2018 2.6.3 Chemical Splash in the Eye ............................................................................... 21 2.6.4 Ingestion of Hazardous Chemicals .................................................................... 21 2.6.5 Inhalation of Smoke, Vapors and Fumes ........................................................... 21 2.6.6 Organo-Heavy Metal Compounds ..................................................................... 22 2.6.7 Cyanide .............................................................................................................. 22 2.6.8 Hydrogen Fluoride/Hydrofluoric Acid .............................................................. 22 2.6.8.1 Skin Exposure to HF ....................................................................................... 22 2.6.8.2 Eye Exposures to HF ...................................................................................... 22 2.6.8.3 Inhalation Exposures to HF ............................................................................ 22 2.7 FIRE AND FIRE RELATED EMERGENCIES ........................................................... 23 2.8 CHEMICAL WASTE DISPOSAL PROGRAM ........................................................... 23 SECTION 3.0 HEALTH AND SAFETY INFORMATION FOR WORK WITH CHEMICALS OF SPECIFIC HAZARD CLASS ............................................................................... 24 3.1 FLAMMABLE LIQUIDS ............................................................................................. 24 3.l.l General Information ........................................................................................... 24 3.1.2 Special Handling Procedures ............................................................................. 24 3.2 HIGHLY REACTIVE CHEMICALS & HIGH ENERGY OXIDIZERS ..................... 25 3.2.1 General Information .......................................................................................... 25 3.2.2 Special Handling Procedures for Highly Reactive Compounds ........................ 26 3.2.3 Special Procedures for Peroxide Forming Compounds ..................................... 27 3.2.4 Special Handling Procedures for Pyrophoric Chemicals ................................... 27 3.3 COMPRESSED GASES ............................................................................................... 29 3.3.1 General Information .......................................................................................... 29 3.3.3 Special Precautions for Hydrogen ..................................................................... 30 3.3.4 Special Requirements for Toxic, Corrosive and Flammable Gases .................. 30 3.4 CORROSIVE CHEMICALS ........................................................................................ 31 3.4.1 General Information .......................................................................................... 31 3.4.2 Special Handling Procedures ............................................................................. 31 3.5 REGULATED CHEMICALS & PARTICULARLY HAZARDOUS CHEMICALS – CARCINOGENS, REPRODUCTIVE TOXINS, AND ACUTELY TOXIC MATERIALS .......... 32 3.5.1 General Information .......................................................................................... 32 3.5.2 Special Handling Procedures ............................................................................. 32 3.6 DEPARTMENT OF HOMELAND SECURITY (DHS) REGULATED CHEMICALS34 3.6.1 General Information .......................................................................................... 34 3.6.2 Special Handling Procedures ............................................................................. 34 SECTION 4.0 CHEMICAL TOXICOLOGY ............................................................................... 34 4.1 CHEMICAL TOXICOLOGY OVERVIEW ................................................................. 34 4.1.1 Definitions ......................................................................................................... 34 4.1.2 Dose-Response Relationships ............................................................................ 35 4.1.3 Routes of Entry into the Body ........................................................................... 35 4.1.4 Types of Effects ................................................................................................
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