Pterospermum Acerifolium Willd) Arunthia Mitra1* and Manisha Mishra2
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qwertyuiopasdfghjklzxcvbnmq wertyuiopasdfghjklzxcvbnmqw ertyuiopasdfghjklzxcvbnmqwer tyuiopasdfghjklzxcvbnmqwerty uiopasdfghjklzxcvbnmqwertyuiInt J Ayu Pharm Chem www.ijapc.com opasdfghjklzxcvbnmqwertyuiope ISSN - 2350-0204 Volume 8 Issue 3 5/10/2018 asdfghjklzxcvbnmqwertyuiopas dfghjklzxcvbnmqwertyuiopasdf Greentree Group ghjklzxcvbnmqwertyuiopasdfgh jklzxcvbnmqwertyuiopasdfghjkl zxcvbnmqwertyuiopasdfghjklzx cvbnmqwertyuiopasdfghjklzxcv bnmqwertyuiopasdfghjklzxcvbn mqwertyuiopasdfghjklzxcvbnm Greentree Group qwertyuiopasdfghjklzxcvbnmqReceived 20/02/18 Accepted 19/04/18 Published 10/05/18 ____________________________________________________________________________________________________ Mitra and Mishra 2018 Greentree Group © IJAPC Int J Ayu Pharm Chem 2018 Vol. 8 Issue 3 www.ijapc.com 113 wertyuiopasdfghjklzxcvbnmqw[e ISSN 2350-0204] ertyuiopasdfghjklzxcvbnmrtyui Int J Ayu Pharm Chem REVIEW ARTICLE www.ijapc.com e-ISSN 2350-0204 A Pharmacological Review of Muchakunda (Pterospermum acerifolium Willd) Arunthia Mitra1* and Manisha Mishra2 1,2 Department of Dravyaguna,Rani Dullaiya Smriti Ayurved P.G. Mahavidhyalayaevam Chikitsalaya, Bhopal (M.P.), India ABSTRACT Ayurvedic herbology deals with description of herbs and plants with medicinal properties and various applications in disease therapy. Muchakunda is one such tree which is valued for its therapeutic potential in diseases of cough and cold, in skin disorders like scabies, a potential wound healer and also useful in inflammation and pain. Ayurvedic texts also refer its uses in headache and bleeding disorders. It belongs to the family Sterculiaceae and is commonly found all over India. This article deals with a comprehensive review on various pharmacological activity of this tree to validate its use in Ayurvedic practice.The subject matter has been reviewed from Ayurvedic texts, various research article published in journals and review articles on the internet. KEYWORDS Muchakunda, Pterospermum acerifolium, Phytoconstituents, Pharmacological action Greentree Group Received 20/02/18 Accepted 19/04/18 Published 10/05/18 ____________________________________________________________________________________________________ Mitra and Mishra 2018 Greentree Group © IJAPC Int J Ayu Pharm Chem 2018 Vol. 8 Issue 3 www.ijapc.com 114 [e ISSN 2350-0204] INTRODUCTION Muchakunda (Pterospermum acerifolium) Prativishnuk, Adhyarhi, Lakshmanav, belonging to Streculiaceae family is a Raktaprasav,Vasu . well-known medicine in Ayurvedic texts. It Hindi -Muchakunda, is also known with these synonyms such Kanakchampa,Kaniar, Katha champa. Chhatravruksha, Chitrakand Marathi - Gujarati-Muchakunda Prativishnuk,Bahupatra. The habitat for English- Bayur tree, Maple leaf Bayur this tree is eastern and south western coast tree, Dinner plate tree of India, especially Bengal, Orissa, Assam AYURVEDIC and Konkan region. The phytochemistry CLASSIFICATION2,3,4: suggests presence of volatile oil in the Bhavprakashnighantu- Pushpavarga flowers. Muchakunda has been described Kaidevanighantu- Aushadivarga as a useful plant in various disorders like Rajnighantu- Karviradivarga headache, bleeding disorders, cough, skin RASA PANCHAK : diseases, wound healers and anti- Guna-Laghu, Ruksha inflammatory. Traditionally it has been Rasa-Kashaya, Katu, Tikta described as astringent, bitter and pungent Virya -Slightly Ushna in taste, slightly hot and a little dry. Vipaka-Katu Currently a lot of experimental work has HABITAT: been done to explore the therapeutic Sub Himalayan tract and outer valleys potential of Muchakunda. from Yamuna eastwards to west Bengal, TAXONOMY: Assam, Manipur up to an altitude of 1200 Kingdom: Plantae m extending towards Bihar, Western Ghats Division: Angiospermae of Konkan and North Karnataka and Order:Malvales Andaman’s islands5. Family: Sterculiaceae BOTANICAL DESCRIPTION: Genus: Pterospermum An evergreen tree, up to 24 m in heightand Species:Aacerifolium 1 2.5 m in girth with a clean bole up to 12 m, VERNACULAR NAMES : Bark: greyishbrown, Leaves: variable in Sanskrit names-Bahupatra, size and shape 25-35 cm ×15-30 cm, entire Sudala,Harivallabha, or variously lobed, oblong, cordite or Supushpa,Kshtravruksha, Chitrak, sometimes palate. The leaves are rough ____________________________________________________________________________________________________ Mitra and Mishra 2018 Greentree Group © IJAPC Int J Ayu Pharm Chem 2018 Vol. 8 Issue 3 www.ijapc.com 115 [e ISSN 2350-0204] and rubbery to limit the loss of moisture in AYURVEDIC USES OF a hot climate.(Figure 1) The bottom side of MUCHKUNDA the leaves range from a silver to rust It is used in painful and inflammatory colour and are pubescent.Flowers: Large conditions hence used in headaches. It is 12-15 cm in diameter, axillary, solitary or also hemostyptic hence used in bleeding in pairs, white, fragrant. Capsules: Oblong piles and Raktapitta. In measles a paste is 5 angled, dark brown and woody, applied to reduce the burning sensation of Seeds:Winged, brown. The tree coppices the skin. In bleeding piles flowers is given well and produces root suckers. Natural with ghee and sugar orally to reduce regeneration is by both seeds and root bleeding. It is useful in cough and sore suckers5. (Figure 2- Figure 3) throat. It can also be used as an antidote for various types of poisoning 6 (vishaghna) . Dosage: 3-6 gms Ayurvedic formulation: Himanshutaila PHYTOCHEMISTRY The alcoholic extract of flowers contain kaempferol and kaempferide-7-glucoside2. Figure 1 Muchkunda Leaf A mixture of acids like myristic, palmitic, stearic, arachidic, behenic, lignoceric, oleic, linoleic and linolenicacids. And saturated hydrocarbons were found from the light petroleum extract of the dried flowers7. The bark contains Betulin, lupeol, bauerenol, friedelin and β- Figure 2 Muchkunda Flower sitosterol. The bark also contains Kaempferol, kaempferol-3-O-galactoside, luteolin7-O-glucoside, luteolin-7-O- glucoronide, kaempferide-7-O-beta- Dglucopyranoside,D-galactouroniacid,D- galactos and L-rhamnose8,9.The seeds contain palmitic, stearic, arachidic, behenic, mystric, lignoceric, oleic, linoleic, Figure 3 Muchkunda Fruits ____________________________________________________________________________________________________ Mitra and Mishra 2018 Greentree Group © IJAPC Int J Ayu Pharm Chem 2018 Vol. 8 Issue 3 www.ijapc.com 116 [e ISSN 2350-0204] linolenic acids.Trunk bark and seeds gave helped in isolation and identification of the amino acids tyrosin, cystine, glycine, two new flavones and one new lactone, 10 alanine and leucine . along with 14 other known BIOLOGICAL AND phytochemicals. The osteogenic activity PHARMACOLOGICAL ACTIVITY was studied in the primary cultures of rat Many pharmacological studies have been osteoblast which revealed a marked conducted on Pterospermum acerifolium. increase in expression of ALP and alizarin A summary of these findings by various red-S staining of osteoblasts.These new investigators is described briefly in the compounds stimulated osteoblast 12 following sections. differentiation and mineralization . ANTIDIABETIC ACTIVITY WOUND HEALING ACTIVITY A study of Inhibition of α-amylase was The study was done to assess wound carried out on the ethanol extract of healing activity and effect on tumour flowers of Pterospremum acerifolium and necrosis factor α of ethanolic extract of its various fractions. The ethyl acetate Pterospermum acerifolium flowers on fraction showed significant inhibition of excision model of wound repair in Albino alpha amylase promising anti diabetic Wistar rats. The rats were divided into activity hence, it was further reduced to 3 three groups with 1 group serving as a fractions and all were screened for control with only application of petroleum antidiabetic activity in streptozotocin- jelly while the other two groups got local nicotinamide induced type II diabetes in application of petroleum jelly with 10% rats. Diabetic animals treated with fraction extract and the final was prefed with P. 2 at the dose of 30 mg/kg reduced the acerifolium extract and local application. levels of fasting blood glucose, P. acerifolium extract showed faster significantly compared to that of the wound healing activity. Also (TNF-α) control. The mode of action can be levels were higher in rats prefed with attributed to increasing the glucose usage 250mg/ kg body weight of P. acerifolium by peripheral tissues and by inhibiting extract daily for 20 days. The study gives glucose formation11. conclusive evidence of wound healing activity with suggestion of induction of OSTEOGENIC ACTIVITY TNF – α activity found in P. acerifolium The study on ethanol extracts of flower13. the Pterospermum acerifolium flowers ANTI-CANCER ACTIVITY ____________________________________________________________________________________________________ Mitra and Mishra 2018 Greentree Group © IJAPC Int J Ayu Pharm Chem 2018 Vol. 8 Issue 3 www.ijapc.com 117 [e ISSN 2350-0204] Ethanol and Water extracts of extracts and different fractions like Ether, Pterospermum acerifolium showed good Choloroform, Ethyl acetate and n=Butanol antimitotic activity against meristamatic from leaves, barks and flowers cell growth. Both extracts also showed ofMuchakunda. Anthelmintic activity of good inhibition on yeast cell growth with these crude extracts and fractions were IC50 47.88 mg/ml and 39.15 mg/ml investigated against regular intestinal respectively. The mode of action of both worms like earthworms, Nematodes and extract with anti-proliferative activity was tapeworms. The reference