High Performance Computing and Networking
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Genetically Engineered Plants: a Potential Solution to Climate Change
Genetically Engineered Plants: A Potential Solution to Climate Change Dr Charles DeLisi GENETICALLY ENGINEERED PLANTS: A POTENTIAL SOLUTION TO CLIMATE CHANGE Climate change is already having devastating effects felt across the globe. Without adequate measures to counteract the human drivers behind climate change, these negative consequences are guaranteed to increase in severity in the coming decades. Esteemed biomedical scientist, Dr Charles DeLisi of Boston University, urges that a multi-disciplinary approach to mitigating climate change is vital. Using predictive modelling, he has demonstrated the potential power of genetically engineering plants to remove excess carbon dioxide from the atmosphere, thereby mitigating climate change. ‘During the post-industrial period, the planetary temperature has increased rapidly,’ explains Dr Charles DeLisi of Boston University. ‘Ice sheet melting has accelerated, ocean levels have risen with concomitant increases in coastal flooding, and extreme weather events have increased in frequency.’ Emissions Reductions: Not the Whole Solution Thus far, measures to tackle climate change have focused on reducing our emissions of carbon dioxide and other greenhouse gases. Over the last three The Climate Emergency These changes are driven by increasing decades, over 100 nations across the levels of atmospheric ‘greenhouse globe have signed multiple agreements Climate change is, arguably, the most gases’, such as carbon dioxide. Released to voluntarily limit their emissions, significant global threat that society as a by-product of fossil fuel combustion but these measures alone are proving faces. Even small perturbations and other human activities, the level ineffective at slowing climatic in the planet’s climatic system of carbon dioxide in the atmosphere disruption. -
& Electrical Engineering
COMPUTER ARCUTECTURFL Gordon Bell Vice President, Engineering Digital Equipment Corporation & Professor of Computer Science & Electrical Engineering Carnegie-Mellon University (on leave) Abstract Minimal cost computer designs ( i.e. minicomputers) are predicated on using technological cost-performance improvements which occur at an annual rate of 25-305. New applications are thereby feasible with the decreasing costs. A significant number of minicomputers are manufactured in which the cost is constant (or rising), thereby providing more performance (capabilities). The higher performance machines "taket1 their characteristics from the larger, general purpose camputers (e.g. floating point arith- metic, multiprocessors, cache memories and memory management) . The origin and evolution of the minicomputer will be discussed with regard to technology and applications. 7 17178 THR PDP-I? FAMILY AND VAX-Ill780 FOR A LARGE VIRTUAL ADDRESS Gordon Bell Vice President, Engineering Digital Equipment Corporation & Professor of Computer Science & Electrical Engineering Carnegie-Mellon University (on leave) Abstract In the eight years the PDP-11 has been on the market, more than 50,000 units in ten different models have been sold. Although one of the system design goals was a broad range of models, the actual range of 500 to 1 (in price and memory size) has exceeded the design goal. The PDP-11 was designed and first implemented to be a mall minicomputer. Its first extension was to a bigger physical address, memory segmentation for multiprogramming and for higher performance. This part of the talk will briefly reflect the experience in the design process, comment on its success from the point of view of the goals, and its use of technology. -
Bioinformatics
Bioinformatics 1 ioinformatics is a hybrid science that links biological data with techniques for information storage, distribution, and analysis to support multiple areas of scientific Bresearch, including biomedicine. Bioinformatics is fed by high-throughput data- generating experiments, including genomic sequence determinations and measurements of gene expression patterns. Database projects curate and annotate the data and then distribute it via the World Wide Web. Mining these data leads to scientific discoveries and to the identification of new clinical applications. In the field of medicine in particular, a number of important applications for bioinformatics have been discovered. For example, it is used to identify correlations between gene sequences and diseases, to predict protein structures from amino acid sequences, to aid in the design of novel drugs, and to tailor treatments to individual patients based on their DNA sequences (pharmacogenomics). “[Helix]”, ill. under ‘’Bioinformatics’’, S [&] T: Dependable Solutions, www.stcorp.nl/step/bioinformatics 120431 Bibliotheca Alexandrina Updated by Ghada Sami 1 The goal of bioinformatics is the extension of experimental data by predictions. A fundamental goal of computational biology is the prediction of protein structure from an amino acid sequence. The spontaneous folding of proteins shows that this should be possible. Progress in the development of methods to predict protein folding is measured by biennial Critical Assessment of Structure Prediction (CASP) programs, which involve blind tests of structure prediction methods. Bioinformatics is also used to predict interactions between proteins, given individual structures of the partners. This is known as the “docking problem.” Protein-protein complexes show good complementarity in surface shape and polarity and are stabilized largely by weak interactions, such as burial of hydrophobic surface, hydrogen bonds, and van der Waals forces. -
Intellectual Property Rights in an Age of Electronics and Information
Intellectual Property Rights in an Age of Electronics and Information April 1986 NTIS order #PB87-100301 Recommended Citation: U.S. Congress, Office of Technology Assessment, lntellectual Property Rights in an Age of Electronics and Information, OTA-CIT-302 (Washington, DC: U.S. Govern- ment Printing office, April 1986). Library of Congress Catalog Card Number 86-600522 For sale by the Superintendent of Documents U.S. Government Printing Office, Washington, DC 20402 Foreword This report examines the impact of recent and anticipated advances in com- munication and information technologies on the intellectual property system. It focuses primarily on the Federal copyright system, and on the continuing effec- tiveness of copyright law as a policy tool in the light of technologies such as audio- and videorecorders, computer programs, electronic databases, and telecommuni- cations networks. To obtain a comprehensive view, the study examined the intel- lectual property system from a number of perspectives: the constitutional basis of intellectual property policy; the system’s goals, laws, and economics; the crea- tive environment; problems of enforcement; the international context; and the Fed- eral role in administering intellectual property rights. OTA found that technological developments are affecting all aspects of the intellectual property system. Moreover, because we are only beginning to move into the era of electronic information, the full impact of new technologies will not become fully apparent for some time. Fundamental changes are occurring in in- formation technologies that will antiquate many of the policy mechanisms now in force, and bring new intellectual property problems requiring new solutions. Thus, even if Congress acts now in response to current problems, it will need to be prepared to act again within the next decade. -
Boston University Graduate Program in Bioinformatics Handbook 2012
1 Boston University Graduate Program in Bioinformatics Handbook 2012-2013 http://www.bu.edu/bioinformatics Department of Biochemistry (School of Medicine) Department of Biology (College of Arts and Sciences) Biomedical Engineering Department (College of Engineering) Department of Biostatistics (School of Public Health) Department of Chemistry (College of Arts and Sciences) Department of Computational Biomedicine (School of Medicine) Department of Computer Science (College of Arts and Sciences) Electrical and Computer Engineering Department (College of Engineering) Genetics and Genomics Department (School of Medicine) Department of Mathematics and Statistics (College of Arts and Sciences) Department of Medicine (School of Medicine) Department of Microbiology (School of Medicine) Department of Mechanical Engineering (College of Engineering) Molecular and Cell Biology (Goldman School of Dental Health) Department of Neurology (School of Medicine) Periodontology & Oral Biology (Goldman School of Dental Health) Department of Physics (College of Arts and Sciences) Pulmonary Medicine (School of Medicine) Systems Engineering Division (College of Engineering) Center for Computational Science Center for Advanced Biotechnology Center for Advanced Genomic Technology Last Updated: 10/11/12 2 Bioinformatics Faculty and Staff Faculty Director Thomas Tullius Director of Bioinformatics Associate Directors Gary Benson* Associate Director of IGERT Scott Mohr Administrative Director, Director of Graduate Studies Department of Biochemistry (BUSM) Joseph Zaia Professor Associate Director, Center for Biomedical Mass Spectrometry Department of Biology (CAS) Cynthia Bradham Assistant Professor Geoffrey M. Cooper Professor, Associate Dean of the Faculty, Natural Sciences John Finnerty Associate Professor Ulla Hansen Professor Edward Loechler Professor Kimberly McCall Associate Professor # Daniel Segre* Associate Professor Dean Tolan Professor David Waxman Professor Department of Biomedical Engineering (ENG) Charles Cantor* Professor, Director of Center for Advanced Biotechnology James J. -
Andrew J. and Erna Viterbi Family Archives, 1905-20070335
http://oac.cdlib.org/findaid/ark:/13030/kt7199r7h1 Online items available Finding Aid for the Andrew J. and Erna Viterbi Family Archives, 1905-20070335 A Guide to the Collection Finding aid prepared by Michael Hooks, Viterbi Family Archivist The Andrew and Erna Viterbi School of Engineering, University of Southern California (USC) First Edition USC Libraries Special Collections Doheny Memorial Library 206 3550 Trousdale Parkway Los Angeles, California, 90089-0189 213-740-5900 [email protected] 2008 University Archives of the University of Southern California Finding Aid for the Andrew J. and Erna 0335 1 Viterbi Family Archives, 1905-20070335 Title: Andrew J. and Erna Viterbi Family Archives Date (inclusive): 1905-2007 Collection number: 0335 creator: Viterbi, Erna Finci creator: Viterbi, Andrew J. Physical Description: 20.0 Linear feet47 document cases, 1 small box, 1 oversize box35000 digital objects Location: University Archives row A Contributing Institution: USC Libraries Special Collections Doheny Memorial Library 206 3550 Trousdale Parkway Los Angeles, California, 90089-0189 Language of Material: English Language of Material: The bulk of the materials are written in English, however other languages are represented as well. These additional languages include Chinese, French, German, Hebrew, Italian, and Japanese. Conditions Governing Access note There are materials within the archives that are marked confidential or proprietary, or that contain information that is obviously confidential. Examples of the latter include letters of references and recommendations for employment, promotions, and awards; nominations for awards and honors; resumes of colleagues of Dr. Viterbi; and grade reports of students in Dr. Viterbi's classes at the University of California, Los Angeles, and the University of California, San Diego. -
Molecular Biology, Cell Biology & Biochemistry (MCBB) Graduate
2016-2017 Molecular Biology, Cell Biology & Biochemistry (MCBB) Graduate Program Guide Table of Contents MCBB Graduate Program Administration.................................................................................................................................... 5 Participating Staff by Department.................................................................................................................................................. 6 Participating Faculty by Department............................................................................................................................................ 7 Facilities.................................................................................................................................................................................................... 10 MCBB Program Requirements.......................................................................................................................................................... 12 • Seminars................................................................................................................................................................................... 12 • Ph.D. Course Requirements............................................................................................................................................... 13 • M.A. Course Requirements............................................................................................................................................... -
Human Genome Project
Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.[1] It remains the world's largest collaborative biological project.[2] After the idea was picked up in 1984 by the US government when the planning started, the project formally launched in 1990 and was declared complete in 2003[3]. Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Logo HGP; Vitruvian Man, Leonardo Germany, Spain and China.[4] da Vinci The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The "genome" of any given individual is unique; mapping the "human genome" involved sequencing a small number of individuals and then assembling these together to get a complete sequence for each chromosome. Therefore, the finished human genome is a mosaic, not representing any one individual. Contents Human Genome Project History State of completion Applications and proposed -
The High Road to the Human Genome
A ccomplishing S e q u e n c in g t h e H u m a n G e n o m e Andrew Bartlett Submitted to Cardiff University in fulfilment of the requirements for the degree of Doctor of Philosophy September 2008 i UMI Number: U584600 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U584600 Published by ProQuest LLC 2013. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 D e c l a r a t io n This work has not previously been accepted in substance for any degree and is not concurrently submitted in candidature for any degree. Signed ..... y . .........(candidate) Date .............. STATEMENT 1 This thesis is being submitted in partial fulfilment of the requirements for the degree of PhD. S igned /. JjTU..../...... .J.........(cand idate) Date........... STATEMENT 2 This thesis is the result of my own independent work/investigation, except where otherwise stated. Other sources are acknowledged by explicit references. A bibliography is appended. Signed KJ. ) .... (candidate) Date............ .?. .4?.. ■ STATEMENT 3 I hereby give consent for my thesis, if accepted, to be available for photocopying and for inter-library loan, and for the title and summary to be made available to outside organisations. -
Human Genome Program in 1986.”
extracted from BER Exceptional Service Awards 1997 EXCEPTIONAL SERVICE AWARD for Exploring Genomes Charles DeLisi .................................................................. 20 Betty Mansfield ................................................................ 22 J. Craig Venter .................................................................. 24 Exploring Genomes Exploring OE initiated the world’s first development of biological resources; cost- genome program in 1986 after effective, automated technologies for mapping Dconcluding that the most useful approach for and sequencing; and tools for genome-data detecting inherited mutations—an important analysis. The project currently is on track to DOE health mission—is to obtain a complete deliver the sequence of 3 billion human base DNA reference sequence. In addition, the pairs by 2005. analytical power developed in pursuit of that Vital to the project’s continued suc- goal will lead to myriad applications in widely cess is DOE’s consistent and focused com- disparate fields including bioremediation, mitment to disseminating information about medicine, agriculture, and renewable energy. the progress, resources, and other results Many are surprised to learn that the generated in the Human Genome Project. longest-running federally funded genome These communication efforts also inform research effort is the 12-year-old DOE Human researchers across the broader scientific Genome Program. Its goal is to analyze the community, who are beginning to apply the genetic material—the genome—that -
Boston University Photonics Center Annual Report 2019 the Above Image Is an Overview of MEMS Mirror Design
Boston University Photonics Center Annual Report 2019 The above image is an overview of MEMS mirror design. The image, featuring Professor David Bishop’s research, is a false color SEM image of the MEMS magnet mirror, comprised of four bimorphs that lift a polysilicon platform off the substrate. A 250 μm cubed N52 magnet is attached to the platform using a custom pick and place micro-gluing technique and a gold plated mirror is glued on top of the magnet using the same gluing technique. (Source: Reprinted with permission from © The Optical Society. C. Pollock, J. Javor, A. Stange, L. K. Barrett, and D. J. Bishop, “Extreme angle, tip-tilt MEMS micromirror enabling full-hemispheric, quasi-static optical coverage,” Optics Express, 2019, 27(11), 15318-15326.) Front cover image: Coupled nonlinear metamaterials, featuring a self-adaptive or intelligent response, serve to enhance the signal-to-noise ratio of magnetic resonance imaging by more than tenfold. (Source: X. Zhao, G. Duan, K. Wu, S.W. Anderson, and X. Zhang, “Intelligent metamaterials based on nonlinearity for magnetic resonance imaging,” Advanced Materials, 2019, 31(49): 1905461. Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.) Letter from the Director THIS ANNUAL REPORT summarizes activities of the Boston University Photonics Center for the 2018-2019 academic year. In it, you will find quantitative and descriptive information regarding our photonics programs in education, interdisciplinary research, business innovation, and technology development. Located at the heart of Boston University’s urban campus, the Photonics Center is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light. -
112N16 Tox Focus
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central Environews Focus A 938 VOLUME 112 | NUMBER 16 | November 2004 • Environmental Health Perspectives Focus | Systems Biology Systems Biology The Big Picture enomics, proteomics, and metab- “Traditionally, scientists—toxicologists G olomics have all vastly advanced included—have relied on a reductionist our understanding of human biology and approach to biology,” says William Suk, disease. But the functioning of even a director of the NIEHS Center for Risk and simple system such as a single yeast cell or Integrated Sciences. Even now, many stud- bacterium is much more complicated ies examine complex systems by looking at than the sum of its genes or proteins or cellular components in isolation. For metabolites; it’s the activity of all those instance, a common experiment involves components and their relationships to using DNA microarrays to observe the one another that add up to a living organ- effect of a chemical exposure on thousands ism. Recognizing that complexity, the of genes at once. This technique can emerging field of systems biology quickly tell a scientist which genes may be attempts to harness the power of mathe- vulnerable to that exposure. But a systems matics, engineering, and computer sci- biology approach would attempt to model ence to analyze and integrate data from all not only the chemical’s effect on gene the “omics” and ultimately create working expression but also how that expression Photodisc, Matt Ray/EHP, Joseph Tart/EHP Photodisc, Matt Ray/EHP, models of entire biological systems.