Stand up to Chronic Migraine with Botox®

#1 PRESCRIBED BRANDED TREATMENT FOR CHRONIC MIGRAINE* Chronic Migraine

DON’T LIE DOWN BOTOX ® STAND UP TO Prevention

CHRONIC MIGRAINE® WITH BOTOX Treatment Experience

*Truven Health MarketScan Data, October 2010-April 2017.

Prevent Headaches and Migraines Before They Even Start BOTOX ® BOTOX® prevents on average 8 to 9 headache days and migraine/probable migraine days a month (vs 6 to 7 for placebo) Savings Program For adults with Chronic Migraine, 15 or more headache days a month, each lasting 4 hours or more. BOTOX® is not approved for adults with migraine who have 14 or fewer headache days a month. Indication • Spread of toxin effects. The effect of botulinum toxin may affect areas BOTOX® is a prescription medicine that is injected to prevent headaches in adults away from the injection site and cause serious symptoms including: loss of with chronic migraine who have 15 or more days each month with headache strength and all-over muscle weakness, double vision, blurred vision and lasting 4 or more hours each day in people 18 years or older. drooping eyelids, hoarseness or change or loss of voice, trouble saying words It is not known whether BOTOX® is safe or effective to prevent headaches clearly, loss of bladder control, trouble breathing, trouble swallowing. in patients with migraine who have 14 or fewer headache days each month There has not been a confirmed serious case of spread of toxin effect away from (episodic migraine). the injection site when BOTOX® has been used at the recommended dose to

IMPORTANT SAFETY INFORMATION treat chronic migraine. Resources BOTOX® may cause serious side effects that can be life threatening. BOTOX® may cause loss of strength or general muscle weakness, vision Get medical help right away if you have any of these problems any time problems, or dizziness within hours to weeks of taking BOTOX®. If this happens, (hours to weeks) after injection of BOTOX®: do not drive a car, operate machinery, or do other dangerous activities. • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at highest Please see additional Important Safety Information throughout risk if these problems are pre-existing before injection. Swallowing problems the brochure. may last for several months. FIND OUT IF YOU’RE LIVING WITH CHRONIC MIGRAINE

3.2 million U.S. Adults

Chronic Migraine is different from other types of migraine headache days 15+ a month (both headaches and migraines count) 30 31 1 2 3 4 5 eadache Migraine 4+ 4+ days of those 15+ 6 7 8 9 10 11 12 + are associated eadache eadache Migraine eadache 8 with migraine 4+ 4+ 4+ 4+ 13 14 15 16 17 18 19 of headache per Migraine Migraine Migraine eadache hours 4+ 4+ 4+ + 4+ headache day 4 20 21 22 23 24 25 26 Migraine eadache Migraine 4+ 4+ 4+

27 28 29 30 1 2 3 Migraine Migraine 4+ 4+

IMPORTANT SAFETY INFORMATION (continued) Dysport ® (abobotulinumtoxinA), or Xeomin ® (incobotulinumtoxinA); have a Do not take BOTOX® if you: are allergic to any of its ingredients skin infection at the planned injection site. (see Medication Guide for ingredients); had an allergic reaction to any ® ® The dose of BOTOX is not the same as, or comparable to, another other botulinum toxin product such as Myobloc (rimabotulinumtoxinB), botulinum toxin product. Chronic Migraine

Talk to your Healthcare Provider to find out more about Chronic Migraine

Count ALL Headache and Migraine Days to see if you have Chronic Migraine

Think about days when Count any day you took Keep track with you had no headache, a medicine to treat a headache diary, which may be easier headache symptoms then bring it to to remember every appointment

Know the difference

Episodic Chronic Migraine Migraine

u 14 or fewer headache days per month u 15 or more headache days per month (at least (some of them may be migraine days) 8 of which are associated with migraine) u May go long periods between headaches u Headaches or migraines occur on at least half and migraines of days per month u Headaches don’t last as long u Headaches last longer u Pain is often less severe u Pain is often more severe

IMPORTANT SAFETY INFORMATION (continued) Get medical help right away if you experience symptoms; further injection Serious and/or immediate allergic reactions have been reported, of BOTOX® should be discontinued. including itching, rash, red itchy welts, wheezing, asthma symptoms, or Please see additional Important Safety Information throughout dizziness or feeling faint. this brochure. PREVENT HEADACHES AND MIGRAINES BEFORE THEY EVEN START Acute Treatments Preventive Treatments Taken after headache/migraine pain Taken on a schedule to prevent has started to reduce symptoms headaches/migraines before they start

Because Chronic Migraine is so severe, guidelines* recommend use of preventive treatments

*American Academy of Neurology guidelines.

IMPORTANT SAFETY INFORMATION (continued) as you may be at increased risk of serious side effects including difficulty Tell your doctor about all your muscle or nerve conditions such as swallowing and difficulty breathing from typical doses of BOTOX®. ALS or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome, Talk to your Healthcare Provider to find out more about BOTOX® Prevention BOTOX

® ®

BOTOX Prevention prevents on headache days average to and migraine/ probable migraine days a month (vs 6 to 7 with placebo) after 2 treatments at 24 weeks

IMPORTANT SAFETY INFORMATION (continued) pregnant (it is not known if BOTOX® can harm your unborn baby); are Tell your doctor about all your medical conditions, including if you: have breastfeeding or plan to (it is not known if BOTOX® passes into breast milk). or have had bleeding problems; have plans to have surgery; had surgery on your Please see additional Important Safety Information throughout face; weakness of forehead muscles; trouble raising your eyebrows; drooping this brochure. eyelids; any other abnormal facial change; are pregnant or plan to become THE FIRST FDA-APPROVED PREVENTIVE TREATMENT FOR CHRONIC MIGRAINE

The Path to FDA Approval Studied in large clinical Met FDA requirements for FDA approved trials of people with safety and effectiveness in in 2010 Chronic Migraine these Chronic Migraine trials

IMPORTANT SAFETY INFORMATION (continued) Do not start any new medicines until you have told your doctor that Tell your doctor about all the medicines you take, including prescription you received BOTOX® in the past. and nonprescription medicines, vitamins, and herbal products. Using BOTOX® with certain medicines may cause serious side effects. Talk to your Healthcare Provider® to find out more about BOTOX

® BOTOX is an established option for Chronic Migraine Million million BOTOX® treatments given to 500,000 Chronic Migraine patients since its approval in 2010*

1.7*Results may vary. Based on IMS Health PharmetricsMillion Plus data.

IMPORTANT SAFETY INFORMATION (continued) relaxants; take allergy or cold medicines; take sleep medicine; take aspirin-like Tell your doctor if you received any other botulinum toxin product in the last products or blood thinners. 4 months; have received injections of botulinum toxin such as Myobloc ®, Please see additional Important Safety Information throughout Dysport ®, or Xeomin ® in the past (tell your doctor exactly which product you this brochure. received); have recently received an antibiotic injection; take muscle LEARN MORE ABOUT THE TREATMENT SCHEDULE About 15 minutes per treatment

Treatments take about 15 minutes and are done in a normal exam room

IMPORTANT SAFETY INFORMATION (continued) blurred vision, decreased eyesight, drooping eyelids, swelling of eyelids, Other side effects of BOTOX® include: dry mouth, discomfort or pain at the and dry eyes. injection site, tiredness, headache, neck pain, and eye problems: double vision, For more information refer to the Medication Guide or talk with your doctor. Talk to your Healthcare Provider to find out more about BOTOX® treatment

Treatments every 12 weeks

You’ll start with 2 treatments, 12 weeks apart, the proven way to see how well BOTOX® is working.

Treatment 30 31 1 2 3 4 5

27 28 29 30 1 2 3 Treatment Experience 6 7 8 9 110 11 12 1 2 3 4 5 6 7 4 5 6 7 8 9 10 13 14 15 16 17 18 19

8 9 10 11 12 13 14 11 12 13 14 15 16 17 20 21 22 23 24 25 26

15 16 17 18 19 20 21 18 19 20 21 22 23 24 27 28 29 30 1 2 3 Treatment 22 23 24 25 26 27 28 25 26 27 28 29 30 31

29 30 31 1 2 2 3 4

® Based on how well BOTOX treatment is working for you, your doctor may discuss re-treatment every 12 weeks

IMPORTANT SAFETY INFORMATION (continued) Please see accompanying Summary of Information about BOTOX®. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. ® YOU MAY PAY $0 OUT OF POCKET FOR BOTOX TREATMENT

® Most insurance plans cover the cost of treatment. The BOTOX Savings Program helps with out-of-pocket costs, providing up to $400 per treatment.*,†,‡ If you’re commercially out of pocket insured and eligible, for BOTOX® you may pay $ treatment 0

Checking eligibility and signing up for savings is easy. Visit BOTOXSavingsProgram.com for Program details and to get started.

*Coverage and out-of-pocket costs vary. †Covers out-of-pocket costs for BOTOX® for up to $2000 in a 12-month period. ‡Must be commercially insured and meet eligibility criteria to qualify. Please see terms and conditions. IMPORTANT SAFETY INFORMATION (continued) • Problems swallowing, speaking, or breathing, due to weakening BOTOX® may cause serious side effects that can be life threatening. of associated muscles, can be severe and result in loss of life. You are at Get medical help right away if you have any of these problems any highest risk if these problems are pre-existing before injection. Swallowing time (hours to weeks) after injection of BOTOX®: problems may last for several months. Talk to your Healthcare ®Provider to find out more about the BOTOX Savings Program

® Stephanie’s experience with the BOTOX Savings Program

“Insurance coverage and cost were definitely factors when considering BOTOX®.” BOTOX ® Savings Program “Fortunately, I can use my insurance, and the BOTOX® Savings Program helps cover the rest of the cost, so I’ve been using it from the start.” Stephanie, on-the-go saleswoman, Illinois

IMPORTANT SAFETY INFORMATION (continued) There has not been a confirmed serious case of spread of toxin effect away • Spread of toxin effects. The effect of botulinum toxin may affect areas from the injection site when BOTOX® has been used at the recommended dose away from the injection site and cause serious symptoms including: loss of to treat chronic migraine. strength and all-over muscle weakness, double vision, blurred vision and Please see additional Important Safety Information throughout this drooping eyelids, hoarseness or change or loss of voice, trouble saying words brochure. clearly, loss of bladder control, trouble breathing, trouble swallowing. RESOURCES AVAILABLE FOR YOU

Visit BOTOXChronicMigraine.com to further your education about Chronic Migraine and BOTOX® treatment

Sign up for appointment reminders, information about managing Chronic Migraine, and healthy living tips at BOTOXChronicMigraine.com/Register

IMPORTANT SAFETY INFORMATION (continued) botulinum toxin product such as Myobloc ® (rimabotulinumtoxinB), Dysport ® BOTOX® may cause loss of strength or general muscle weakness, vision (abobotulinumtoxinA), or Xeomin ® (incobotulinumtoxinA); have a skin infection problems, or dizziness within hours to weeks of taking BOTOX®. If this happens, at the planned injection site. do not drive a car, operate machinery, or do other dangerous activities. The dose of BOTOX® is not the same as, or comparable to, another Do not take BOTOX® if you: are allergic to any of its ingredients (see botulinum toxin product. Medication Guide for ingredients); had an allergic reaction to any other Talk to your Healthcare Provider® to find out more about BOTOX Resources

Program Terms, Conditions, and Eligibility Criteria: 1. This offer is good for use only with a valid prescription for BOTOX® (onabotulinumtoxinA). 2. Based on insurance coverage, Chronic Migraine patients can receive up to $400 off per treatment for up to 5 treatments in 2018. All treatments must be received during 2018. Maximum savings limit of $2000 per year for people with Chronic Migraine applies; patient out-of-pocket expense may vary. 3. This offer is not valid for use by patients enrolled in Medicare, Medicaid, or other federal or state programs (including any state pharmaceutical assistance programs), or private indemnity or HMO insurance plans that reimburse you for the entire cost of your prescription drugs. Patients may not use this offer if they are Medicare-eligible and enrolled in an employer-sponsored health plan or prescription drug benefit program for retirees. This offer is not valid for cash-paying patients. 4. This offer is valid for up to 5 treatments per year. Offer applies only to treatment received before the program expires on 12/31/18. 5. Offer is valid only for BOTOX® and BOTOX® treatment-related costs not covered by insurance. 6. A BOTOX® Savings Program check will be provided upon approval of a claim. The claim must be submitted with treatment details from an Explanation of Benefits (EOB) or a Specialty Pharmacy Provider (SPP) receipt. (If the BOTOX® prescription was filled by a Specialty Pharmacy Provider, both EOB and SPP details must be provided.) All claims must be submitted within 90 days of the date of EOB receipt. You may be required to provide a copy of your EOB or SPP receipt for your claim to be approved. 7. Allergan reserves the right to rescind, revoke, or amend this offer without notice. 8. Offer good only in the USA, including Puerto Rico, at participating retail locations. 9. Void where prohibited by law, taxed, or restricted. 10. This offer is not health insurance. 11. By participating in the BOTOX® Savings Program, you acknowledge that you are an eligible patient and that you understand and agree to comply with the terms and conditions of this offer. For questions about this program, please call 1-800-44-BOTOX, Option 4. Resources

IMPORTANT SAFETY INFORMATION (continued) Tell your doctor about all your muscle or nerve conditions such as ALS Serious and/or immediate allergic reactions have been reported, or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome, as you including itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness may be at increased risk of serious side effects including difficulty swallowing or feeling faint. Get medical help right away if you experience symptoms; further and difficulty breathing from typical doses of BOTOX®. ® injection of BOTOX should be discontinued. Please see additional Important Safety Information throughout this brochure. TALK TO YOUR HEALTHCARE PROVIDER TO LEARN MORE Information you may discuss about your condition

How severe your headaches/ migraines are How the condition affects your daily life How long your headaches/migraines normally last What types of treatments are available to prevent How you responded headache days to treatments you’ve taken

A Chronic Migraine diagnosis may change the course of your treatment plan

IMPORTANT SAFETY INFORMATION (continued) Tell your doctor about all the medicines you take, including prescription Tell your doctor about all your medical conditions, including if you: and nonprescription medicines, vitamins, and herbal products. Using BOTOX® have or have had bleeding problems; have plans to have surgery; had surgery with certain medicines may cause serious side effects. Do not start any new on your face; weakness of forehead muscles; trouble raising your eyebrows; medicines until you have told your doctor that you received BOTOX® drooping eyelids; any other abnormal facial change; are pregnant or plan to in the past. become pregnant (it is not known if BOTOX® can harm your unborn baby); are breastfeeding or plan to (it is not known if BOTOX® passes into breast milk). Talk to your Healthcare Provider to find out more about tracking your headaches

Start a diary or use an app, and bring the record to every appointment to track your progress.

Things to record each month u How many headaches u How long they last u Symptoms u Treatments u Triggers u Headache-free days

My Daily Headache Diary

DATE: 10/28/17

NAME: Jane Smith Headache Migraine  Nothing How long did it last? 6 hours Severity: Mild Moderate Severe  Symptoms: Nausea, vomiting Treatments: Ibuprofen Trigger: Stress

IMPORTANT SAFETY INFORMATION (continued) Please see additional Important Safety Information throughout Tell your doctor if you received any other botulinum toxin product in the last this brochure. 4 months; have received injections of botulinum toxin such as Myobloc ®, Dysport ®, or Xeomin ® in the past (tell your doctor exactly which product you received); have recently received an antibiotic injection; take muscle relaxants; take allergy or cold medicines; take sleep medicine; take aspirin-like products or blood thinners. WHAT’S YOUR NEXT STEP?  Start using a headache diary to share with your healthcare professional  Sign up for the Pathways to Prevention support program at BOTOXChronicMigraine.com/Register  Schedule and set a reminder for your next BOTOX® appointment  Check if you’re eligible to start saving at BOTOXSavingsProgram.com 

IMPORTANT SAFETY INFORMATION (continued) For more information refer to the Medication Guide or talk with your doctor. ® Other side effects of BOTOX include: dry mouth, discomfort or pain at You are encouraged to report negative side effects of prescription drugs to the FDA. injection site, tiredness, headache, neck pain, and eye problems: double vision, Visit www.fda.gov/medwatch or call 1-800-FDA-1088. blurred vision, decreased eyesight, drooping eyelids, swelling of eyelids, ® and dry eyes. Please see accompanying Summary of Information about BOTOX.

References: 1. Data on file, Allergan; Cohort Statistics for Migraine and Product Prevalence. 2. BOTOX® Prescribing Information, April 2017. 3. Data on file, Allergan; PREEMPT 1 Final Report.4. Data on file, Allergan; PREEMPT 2 Final Report. 5. Data on file, Allergan; PREEMPT 1 Efficacy Data.6. Data on file, Allergan; PREEMPT 2 Efficacy Data.7. Centers for Disease Control and Prevention. Census projections request. CDC WONDER website. http://wonder.cdc.gov/ population-projections.html. Accessed October 31, 2017. 8. Natoli JL, Manack A, Dean B, et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia. 2010;30(5):599-609. 9. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version).Cephalalgia . 2013;33(9):629-808. 10. Lipton RB. Chronic migraine, classification, differential diagnosis, and epidemiology. Headache. 2011;51(suppl 2):77S-83S. 11. Blumenfeld AM, Varon SF, Wilcox TK, et al. Disability, HRQoL and resource use among chronic and episodic migraineurs: results from the International Burden of Migraine Study (IBMS). Cephalalgia. 2011;31(3):301-315. 12. Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2000;55(6):754-762. 13. Silberstein SD, Lipton RB, Goadsby PJ. Migraine: diagnosis and treatment. Headache in Clinical Practice. 2nd ed. London, England: Martin Dunitz; 2002:69-111. 14. Data on file, Allergan, November 2017; IMS Health Pharmetrics Plus data: total Chronic Migraine BOTOX® patients since launch. 15. Data on file, Allergan, 2017; In Crowd Physician Survey.16. Data on file, Allergan, 2017; IMS Health Pharmetrics Plus data: BOTOX® Out of Pocket thru Q4, 2015.

© 2017 Allergan. All rights reserved. All trademarks are the property of their respective owners. BOTOXChronicMigraine.com BOTOXSavingsProgram.com 1-800-44-BOTOX BCM76070_v2 12/17 172812 t I S S L A M a e r o t y P p p w

o m t O e o e u c ee t r m R t: i k a T

b s l f

A e o a b Indication c r r m N a o

U r

® 18 , t T p h BOTOX (onabotulinumtoxinA) is a prescription medicine that is injected to prevent e : D l

e s m U

e 201 4 B SPS

headaches in adults with chronic migraine who have 15 or more days each month u r O

R s D t

M with headache lasting 4 or more hours each day in people 18 years or older. N e b F BU S f

O e r i I E n e

® R t T e n It is not known whether BOTOX is safe or effective to prevent headaches in patients gu l a S d

v k E T

e w ( a with migraine who have 14 or fewer headache days each month (episodic migraine). N - 5 n t C i i L t " A W P t o h

L A o x n I ASS O LL E IMPORTANT SAFETY INFORMATION

R s M 7 en s ES T

® " G a B ) I

BOTOX may cause serious side effects that can be life threatening. Get P nd B E . u l N O M y , r O X medical help right away if you have any of these problems any time (hours t a S e R R A u

® E F I C t L G A ESS A to weeks) after injection of BOTOX : o I DUC E M m G 6334 A

a E due to weakening of a • Problems swallowing, speaking, or breathing, L t nd N

i o W D n associated muscles, can be severe and result in loss of life. You are at highest risk if

O ba r PE R I

CHR O N LL c W R these problems are pre-existing before injection. Swallowing problems may last for o m

c M BE E o M p d several months. O a LL N R I e T t VE t PA I

i b a

N r • Spread of toxin effects. The effect of botulinum toxin may affect areas away ili t e O EP L Y D

h y a .

TO GET SUPPORT FROM from the injection site and cause serious symptoms including: loss of strength e

J 07007 - t t F Y a u

and all-over muscle weakness, double vision, blurred vision and drooping eyelids, I

nd a

a M A M l

DDR ESSE E

hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder a i r I nd z

PATHWAYS TO PREVENTION d G R e

control, trouble breathing, trouble swallowing. s

A KO AQ . b ND a A ( P W c r

There has not been a confirmed serious case of spread of toxin effect away from A u c r ) KO AQ o

® 1993 - h du c p C I 970 6 d the injection site when BOTOX has been used at the recommended dose to treat M N o l e a A r s c i L E z e chronic migraine. . e D

e d T d 2012 ,

d A

® he y b

p U

BOTOX may cause loss of strength or general muscle weakness, vision problems, or y r E

op e s

® D LL

I e dizziness within hours to weeks of taking BOTOX . If this happens, do not drive a a A r D r L ,

Fill out and mail the attached form e r Z N Y l S

y car, operate machinery, or do other dangerous activities. z o J M

e l n o e r O n l ® , to get emailed treatment reminders, i y a t V

Please see additional Important Safety Information about BOTOX inside.

l v E

h e # a e nd i r li d s

patient stories, and more! m i o

c a a n i s il a

12 .

, p p ww w i r e i 2 n c . t e 0 ed ! . 2 E nd i c UN I i N a N . O I c E T F o

C E I

P m N M ESS A D O

A T

S S I H L T T E E A A R D G T Y E E S Glue Strip AreaKO (DOESAQ NOT PRINT)

Updates,GET SUPPORT treatment reminders,FROMPATHWAYS real Chronic MigraineTO PREVENTION patient stories, AS andYOU more CONTINUE are available YOURto keep JOURNEY you inspired and help you and your doctor stay on top of your condition. Sign up today!

FIRST NAME LAST NAME

DATE OF BIRTH (You must be at least 18 years of age.) M M D D Y Y Y Y

ADDRESS

CITY STATE ZIP

PHYSICIAN What type of physician are you seeing to manage your Chronic Migraine? Primary Care Physician Neurologist Headache Specialist Pain Specialist Other None

Which of the following describes your BOTOX® (onabotulinumtoxinA) experience? I am not currently using BOTOX®, but am interested in learning more I am planning to receive my first BOTOX® treatment I have received only 1 BOTOX® treatment I have received 2 or more BOTOX® treatments

If you are currently taking BOTOX®, tell us about your BOTOX® treatments: I first began BOTOX® My next BOTOX® treatment on: M M D D Y Y Y Y treatment will be on: M M D D Y Y Y Y (Even an approximate date is helpful so we can send you treatment reminders.)

By filling out and mailing this card, I agree to receive information from Allergan related to education on headache disorders like Chronic Migraine, as well as other Allergan products and services. I understand I can opt out at any time. BCM76070_v2 12/17 [B17AD5] Do nottakeBOTOX IMPORTANT SAFETYINFORMATION (continued) other botulinumtoxinproductsuchas ingredients (seeMedicationGuideforingredients);hadanallergicreactiontoany Serious and/orimmediateallergicreactionshavebeenreported, toxin product. The doseofBOTOX planned injectionsite. (abobotulinumtoxinA), or BOTOX if BOTOX other abnormalfacialchange;arepregnantorplantobecome(it isnotknown weakness offoreheadmuscles;troubleraisingyoureyebrows;droopingeyelids; any onyourface; hadsurgery have hadbleedingproblems;planstosurgery; Tell yourdoctoraboutallmedicalconditions, including ifyou: difficulty breathingfromtypicaldosesofBOTOX may beatincreasedriskofserioussideeffectsincludingdifficultyswallowingand or LouGehrig’s disease, myastheniagravis, orLambert-Eatonsyndrome, asyou Tell yourdoctoraboutallmuscle conditions ornerve should bediscontinued. Get medicalhelprightawayifyouexperiencesymptoms;furtherinjectionofBOTOX itching, rash, reditchywelts, wheezing, asthmasymptoms, ordizzinessfeelingfaint. ® passesintobreastmilk). ® can harm your unborn baby); are breastfeeding or plan to (it is not known if canharmyourunbornbaby);arebreastfeedingorplanto(itisnotknown if ® ® (onabotulinumtoxinA)ifyou: isnotthesameas, orcomparableto, anotherbotulinum Xeomin ® (incobotulinumtoxinA); have a skin infection at the (incobotulinumtoxinA);haveaskininfectionatthe Myobloc ® (rimabotulinumtoxinB), ® .

are allergic to any of its areallergictoanyofits suchas ALS Dysport including including have or haveor ®

1-800-44-BOTOX BCM76070_v2 12/17 [B17AD5] 172812 © 2017 Allergan. All rightsreserved. All trademarksarethe propertyoftheirrespective owners. BOTOXChronicMigraine.com Please see accompanying Summary ofInformationabout BOTOX. Summary Please seeaccompanying Visit www.fda.gov/medwatch orcall1-800-FDA-1088. You areencouragedtoreportnegativesideeffectsofprescriptiondrugstheFDA. For moreinformationrefertotheMedicationGuideortalkwithyourdoctor. decreased eyesight, droopingeyelids, swellingofeyelids, eyes. anddry site, tiredness, headache, neckpain, andeyeproblems: doublevision, blurredvision, Other sideeffectsofBOTOX aspirin-like productsorbloodthinners. injection; takemusclerelaxants;allergyorcoldmedicines;sleepmedicine; (tell yourdoctorexactlywhichproductyoureceived);haverecentlyreceivedanantibiotic received injectionsofbotulinumtoxinsuchas Tell yourdoctorifyoureceivedanyotherbotulinumtoxinproductinthelast4months;have received BOTOX newmedicines untilyouhavetoldyourdoctorthat Do notstartany (onabotulinumtoxinA) withcertainmedicinesmaycauseserioussideeffects. nonprescription medicines, vitamins, andherbalproducts. UsingBOTOX Tell yourdoctoraboutallthemedicinesyoutake, IMPORTANT SAFETYINFORMATION (continued) ® inthepast. ® include: dry mouth,dry discomfortorpainatinjection Myobloc

® , includingprescriptionand Dysport ® , or Xeomin ® ® ®

in the past inthepast

Summary of Information about BOTOX® Tell your doctor if you have or have had breathing (onabotulinumtoxinA) problems such as asthma or emphysema; swallowing What is the most important information problems; bleeding issues; plan to or have had I should know about BOTOX®? surgery; have forehead muscle weakness such as trouble raising your eyebrows; drooping eyelids; or BOTOX® may cause serious side effects that any changes to your face. can be life threatening. Call your doctor or get Tell your doctor if you are pregnant, plan to become medical help right away if you have any of these pregnant, are breastfeeding or plan to breast feed. It is problems any time (hours to weeks) after injection not known if BOTOX® (onabotulinumtoxinA) can harm of BOTOX®: your unborn baby or if BOTOX® passes into breast milk. • Problems swallowing, speaking, or breathing, due What Are Common Side Effects? to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk The most common side effects include neck pain; if these problems are pre-existing before injection. headache; migraine; slight or partial facial paralysis; Swallowing problems may last for several months. eyelid drooping; bronchitis; musculoskeletal stiffness; muscular weakness; pain in 1 or more muscles, • Spread of toxin effects. The effect of botulinum ligaments, tendons, or bones; muscle spasms; toxin may affect areas away from the injection injection site pain; and high blood pressure. Other site and cause serious symptoms including: side effects have been reported including allergic loss of strength and all-over muscle weakness, reactions e.g. itching, rash, red itchy welts, wheezing, double vision, blurred vision and drooping eyelids, asthma symptoms, or dizziness or feeling faint. hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, These are not all of the possible side effects. Call trouble breathing, trouble swallowing. your doctor for medical advice if you experience any side effects after treatment with BOTOX®. There has not been a confirmed serious case of spread of toxin effect away from the injection site What Should I Tell My Doctor About Medicines and when BOTOX® has been used at the recommended Vitamins I Take? dose to treat Chronic Migraine. Using BOTOX® with certain medicines may cause BOTOX® may cause loss of strength or general serious side effects.Do not start any new medicines muscle weakness, vision problems, or dizziness until you have told your doctor that you have within hours to weeks of taking BOTOX®. If this received BOTOX® in the past. Tell your doctor if you happens, do not drive a car, operate machinery, or have received an injection with another botulinum do other dangerous activities. toxin product in the last 4 months, such as Myobloc®, Dysport®, or Xeomin®. Be sure your doctor knows BOTOX® dosing units are not the same as, or which product you received. comparable to, any other botulinum toxin product. Tell your doctor about all prescription and over- What is BOTOX®? the-counter medicines and supplements you take including: vitamins and herbal products; recent BOTOX® is prescription medicine a medical professional antibiotic injections; anticholinergics; muscle injects into muscles to prevent headaches in adults relaxants; allergy or cold medicine; sleep medicine; with Chronic Migraine who have 15 or more days aspirin-like products; and blood thinners. Ask your each month with headache lasting 4 or more hours doctor if you are not sure whether your medicine is each day in people 18 years and older. listed above. It is not known whether BOTOX® is safe or effective To Learn More to prevent headaches in people with migraine who have 14 or fewer headache days each month If you would like more information, talk to your (episodic migraine). doctor and/or go to BotoxChronicMigraine.com for full Product Information. Who should not take BOTOX®? You may report side effects to the FDA at Do not use BOTOX® if you are: allergic to any of www.fda.gov/medwatch or call 1-800-FDA-1088. the ingredients in BOTOX® such as botulinum Based on 72511US15 Rev. 01/2016 toxin type A and human serum albumin; had an allergic reaction to another botulinum toxin APC05FR16 product such as Myobloc® (rimabotulinumtoxinB), ©2016 Allergan. All rights reserved. ® marks owned by Allergan, Inc. Dysport® (abobotulinumtoxinA), or Xeomin® Patented. See: www.allergan.com/products/patent_notices (incobotulinumtoxinA); or have a skin infection at the Myobloc® is a registered trademark of Solstice Neurosciences, Inc. Dysport® is a registered trademark of Ipsen Biopharm Limited Company. planned injection site. Xeomin® is a registered trademark of Merz Pharma GmbH & Co KGaA What should I tell my doctor before treatment? Tell your doctor about all your muscle or nerve conditions, such as amyotrophic lateral sclerosis (Lou Gehrig’s disease), myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects.