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Molecular Simulation Studies of Hydrophobic Gating in Nanopores and Ion Channels
146 Biochemical Society Transactions (2015) Volume 43, part 2 Molecular simulation studies of hydrophobic gating in nanopores and ion channels Jemma L. Trick*, Prafulla Aryal*†‡, Stephen J. Tucker†‡ and Mark S. P. Sansom*‡1 *Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. †Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, U.K. ‡OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford U.K. Abstract Gating in channels and nanopores plays a key role in regulating flow of ions across membranes. Molecular simulations provide a ‘computational microscope’ which enables us to examine the physical nature of gating mechanisms at the level of the single channel molecule. Water enclosed within the confines of a nanoscale pore may exhibit unexpected behaviour. In particular, if the molecular surfaces lining the pore are hydrophobic this promotes de-wetting of the pore. De-wetting is observed as stochastic liquid–vapour transitions within a pore, and may lead to functional closure of a pore to the flow of ions and/or water. Such behaviour was first observed in simulations of simple model nanopores and referred to as ‘hydrophobic gating’. Simulations of both the nicotinic acetylcholine receptor and of TWIK-1 potassium channels (the latter alongside experimental studies) suggest hydrophobic gating may occur in some biological ion channels. Current studies are focused on designing hydrophobic gates into biomimetic nanopores. Introduction One possible mechanism for channel and pore closure is Ion channels and protein (nano)pores play a key role ‘hydrophobic gating’ (also sometimes known as a ‘vapour in membrane biology, allowing rapid movement of ions lock’ mechanism). -
Plaque Schemes Across England
PLAQUE SCHEMES ACROSS ENGLAND Plaque schemes are listed below according to region and county, apart from thematic schemes which have a national remit. The list includes: the name of the erecting body (with a hyperlink to a website where possible); a note of whether the scheme is active, dormant, proposed or complete; and a link to an email contact where available. While not all organisations give details of their plaques on their websites, the information included on the register should enable you to contact those responsible for a particular scheme. In a few cases, plaques are described as ‘orphaned’, which indicates that they are no longer actively managed or maintained by the organisation that erected them. English Heritage is not responsible for the content of external internet sites. BEDFORDSHIRE Bedford Borough ACTIVE Council Various historical schemes BEDFORDSHIRE Biggleswade COMPLETED Contact EAST History Society 1997-2004 BEDFORDSHIRE Dunstable COMPLETED Contact Town Council CAMBRIDGESHIRE Cambridge Blue ACTIVE Contact Plaques Scheme since 2001 CAMBRIDGESHIRE Eatons ACTIVE Contact Community Association 1 PLAQUE SCHEMES ACROSS ENGLAND CAMBRIDGESHIRE Great Shelford ACTIVE Contact Oral History Group CAMBRIDGESHIRE Littleport Society AD HOC One-off plaque erected in 2011, more hoped for. CAMBRIDGESHIRE Peterborough ACTIVE Contact Civic Society since the 1960s CAMBRIDGESHIRE St Ives ACTIVE Contact EAST Civic Society since 2008 CAMBRIDGESHIRE St Neots Local ACTIVE Contact History Society ESSEX (Basildon) PROPOSED Contact Foundation -
Blue Plaque Guide
Blue Plaque Guide Research and Cultural Collections 2 Blue Plaque Guide Foreword 3 Introduction 4 1 Dame Hilda Lloyd 6 2 Leon Abrams and Ray Lightwood 7 3 Sir Norman Haworth 8 4 Sir Peter Medawar 9 5 Charles Lapworth 10 6 Frederick Shotton 11 7 Sir Edward Elgar 12 8 Sir Granville Bantock 13 9 Otto Robert Frisch and Sir Rudolf E Peierls 14 10 John Randall and Harry Boot 15 11 Sir Mark Oliphant 16 12 John Henry Poynting 17 13 Margery Fry 18 14 Sir William Ashley 19 15 George Neville Watson 20 16 Louis MacNeice 21 17 Sir Nikolaus Pevsner 22 18 David Lodge 23 19 Francois Lafi tte 24 20 The Centre for Contemporary Cultural Studies 25 21 John Sutton Nettlefold 26 22 John Sinclair 27 23 Marie Corelli 28 Acknowledgments 29 Visit us 30 Map 31 Blue Plaque Guide 3 Foreword Across the main entrance to the Aston Webb Building, the historic centre of our campus, is a line of standing male figures carved into the fabric by Henry Pegram. If this were a cathedral, they would be saints or prophets; changed the world, from their common home the University but this is the University of Birmingham, and the people of Birmingham. who greet us as we pass through those doors are Beethoven, Virgil, Michelangelo, Plato, Shakespeare, The University’s Research and Cultural Collections, Newton, Watt, Faraday and Darwin. While only one of working with Special Collections, the Lapworth Museum, those (Shakespeare) was a local lad, and another (Watt) the Barber Institute of Fine Arts and Winterbourne House local by adoption, together they stand for the primacy of and Garden, reflect the cross-disciplinary nature of the creativity. -
Blue Plaques in Bromley
Blue Plaques in Bromley Blue Plaques in Bromley..................................................................................1 Alexander Muirhead (1848-1920) ....................................................................2 Benjamin Waterhouse Hawkins (1807-1889)...................................................3 Brass Crosby (1725-1793)...............................................................................4 Charles Keeping (1924-1988)..........................................................................5 Enid Blyton (1897-1968) ..................................................................................6 Ewan MacColl (1915-1989) .............................................................................7 Frank Bourne (1855-1945)...............................................................................8 Harold Bride (1890-1956) ................................................................................9 Heddle Nash (1895-1961)..............................................................................10 Little Tich (Harry Relph) (1867-1928).............................................................11 Lord Ted Willis (1918-1992)...........................................................................12 Prince Pyotr (Peter) Alekseyevich Kropotkin (1842-1921) .............................13 Richmal Crompton (1890-1969).....................................................................14 Sir Geraint Evans (1922-1992) ......................................................................15 Sir -
Physics Meets Biology 2019 9–11 September 2019 University of Oxford, Oxford, UK
Delegate Handbook Physics Meets Biology 2019 9–11 September 2019 University of Oxford, Oxford, UK http://pmb2019.iopconfs.org Contents Contacts 2 Disclaimer 2 Social media 2 Sponsors 3 Committee 3 Venue 4 Site Maps 5 Accommodation 5 WiFi 5 Travel 5 Programme 6 Registration 6 Catering 6 Dietary requirements 6 Social Programme 7 Payment 7 Presenter instructions 8 Poster presentations 8 Safety and emergency evacuation procedures 9 Smoking 9 First aid 9 Weather 9 Conference app 10 1 | Page Contacts If you have any questions or require further information, please contact a member of the Institute of Physics conference organising team, Jason Eghan or Marcia Reais. Jason and Marcia will be on-site for the duration of the conference and will be based on Sunday in St. Anne’s College in the Lodge and then in the Department of Physics, Martin Wood Foyer on the Reception Desk during registration times (see page 6). Outside of these times and only in case of an emergency, please telephone 07884 426 8232. Jason Eghan Tel: +44 (0)207470 4984 Mobile: +44 (0)7884 426 8232 Email: [email protected] Marcia Reais Tel: +44 (0)207470 4831 Email: [email protected] Conferences Tel: +44 (0)20 7470 4800 Email: [email protected] We hope that your time at the conference is trouble free. If you do encounter any problems, please report them to the conferences team who will make every effort to rectify the issue as soon as possible. Disclaimer The Institute of Physics, University of Oxford and their approved representatives accept no responsibility for any accident, loss or damage to participant’s property during the conference. -
Oxford Today 2009, Reproduced with Kind Permission of the the Chancellor, Masters and Scholars of the University of Oxford
A refuge for the persecuted, release for the fettered mind An organisation set up in 1933 to find work for refugee academics is still very much in business. Georgina Ferry reports. Seventy years ago, on 5 February 1939, the great and the good of Oxford poured into the Sheldonian to hear distinguished speakers address 'The Problem of the refugee Scholar'. The aim was to persuade the University and its colleges to open their hearts and their pockets to academics from countries where fascism had deprived them of their livelihood and of the opportunity to teach and research. On the platform was Lord Samuel, former Home Secretary and head of the Council for German Jewry, and Sir John Hope Simpson, the former Indian civil servant whose subsequent career as a colonial administrator had frequently focused on migration, forced and otherwise, in countries as diverse as Kenya and Palestine. Both were Balliol men. Distinguished Oxford figures including the Master of Balliol, A D Lindsay, the Provost of Oriel, Sir William David Ross, and the regius Professor of Medicine, Sir Edward Farquhar Buzzard - had worked indefatigably over the previous five years to create the conditions in which the University would be prepared to stage a high-profile event in such a cause. It all began in 1933, when Sir William Beveridge, then director of the London School of Economics (and subsequently Master of Univ), was on a study trip to Vienna. Reading in a newspaper that, since Adolf Hitler's recent rise to power, Jewish and other non-Nazi professors were losing their jobs in German universities, Beveridge returned to England and mobilised many of his influential friends to form the academic assistance Council (AAC). -
B|D Landscape Architects Review Journal 2010 – 2015 “Landscape Architecture’S Best-Kept Secret (Until Now)”
B|D Landscape Architects Review Journal 2010 – 2015 “Landscape architecture’s best-kept secret (until now)” Peter Tisdale, THAT Property Man Foreword BY rob beswick, director t has been a busy and productive first five years for B|D During the last five years we have been published in a number landscape architects and this journal is a round-up of of architectural journals and shortlisted for a series of Inew, in progress and completed projects. A reminder for awards. In 2013 we featured in a new book on landscape ourselves, existing clients & collaborators of time well spent, architectural graphics, a dialogue piece in an American and a brief moment of B|D reflection to see where we are design journal and won a Civic Trust Award. In 2014 we heading for the next five years! were published in four books and won a national Landscape Institute award. Through testing times we have grown into a progressive and dynamic landscape practice with an increasing number of I am very proud of what we have achieved in a short space award winning and published projects in the UK and overseas. of time and equally optimistic about where we can get to I take great pleasure in seeing each project develop from for our ten year review. I would like to take this opportunity those first flat white fuelled sketches through planning and to thank all of the talented consultants and forward-thinking construction to the completed scheme being enjoyed by the clients who have commissioned or collaborated with us public. The beauty of landscape architecture is that projects during the first five years. -
Campaign Report 2017/18 Welcome
Campaign Report 2017/18 Welcome It is a real privilege to witness the power of philanthropy here at the University of Oxford. The generosity of our donors, coupled with the calibre and ambition of our academics and students, is inspiring and improving lives across the world via a wide range of projects and research. Our Campaign Report for 2017/18 features just a few of the areas that have been supported through the Oxford Thinking Campaign. These include a look at the significance of the Department of Physics’ magnificent new Beecroft Building and how the Bodleian Libraries’ first Education Officer is driving a variety of community, school and public activities. Your support plays a critical role in maintaining the highest levels of academic excellence at Oxford, which in turn enables us to effect positive change on a global scale. Thank you for your continued support. I hope you enjoy this year’s report. Liesl Elder Chief Development Officer University of Oxford Main photography – John Cairns Front cover photography – Radcliffe Camera and University Church © Oxford University Images / David Williams Photography Additional photography – Martin Handley – Global Initiative – Global Jet Watch – Stuart Bebb – Fotohaus – Hawkins\Brown Architects – Dr Karl Harrison – Ian Wallman Design – williamjoseph.co.uk 4 Contents 2 Thanks to your support… 12 Tackling prostate cancer How your donations are making Professor Ian Mills discusses his a difference research into the disease, which now claims the lives of more than 11,000 4 Foundations for new -
Town Centre Heritage Task Group Plaque Selection Process Agenda
3 AIMS, SELECTION PROCESS AND CRITERIA SECTION CONTENTS The Aims of Commemorative Plaques 35 Developing Selection Criteria and Guidelines 37 Selection Process 44 33 The process of nomination and selection is a fundamental element of all plaque schemes. Even in one-off cases, a procedure is followed; at its simplest, this includes the raising of a suggestion and the decision that a plaque is worthwhile (or not, as the case may be). In general, it is likely to involve a wider group of people than those directly responsible for plaque work; notably, one or more proposers (often members of the general public), and a group which is responsible for deciding which proposals are taken forward. The latter may take the form of a committee or advisory panel, and the consideration of plaque nominations may be just one of its functions. In the majority of instances, the selection operation for some time. For instance, the process will be assisted and informed by ‘twenty-year rule’, which states that a person selection criteria and/or guidelines. These should have been dead for a minimum of 20 provide a framework for the fair and consistent years before they can be considered, had been consideration of nominations, and set out a guiding principle for the scheme since the the parameters of the plaque scheme in nineteenth century. These criteria have clearly question: what kind of proposals are eligible proved of widespread practicality and use. In for consideration, what is and is not possible, an adapted form, they have been used as the and the requirements for commemoration. -
London's Blue Plaques
DISCOVER LONDON ENGLISH HERITAGE/MIKE SEAFORTH/DEREK KENDALL HERITAGE/MIKE ENGLISH f London’s past is written in its On 7 May 1866, the precursor to today’s buildings, the blue plaques that adorn panel met for the first time and the result was them, commemorating their illustrious two plaques, both erected in 1867. The first residents, are that tale’s punctuation. commemorated Romantic poet Lord Byron These colourful spots of history, on (1788-1824) at his birthplace of 24 Holles Isites handsome and humble, link the people Street, Cavendish Square, however that of the past, and their achievements, with the house was demolished in 1889. The second, Within buildings of the present. Since the scheme’s and earliest surviving plaque, honours inception 150 years ago, more than 900 Napoleon III (1808-73), the last emperor of plaques have been erected to honour notable the French, in King Street, St James’s. these – and notorious – men and women. Prince Louis Napoleon Bonaparte fled to Now run by English Heritage, the original England (for a second time) after escaping vision has sparked countless imitations imprisonment in 1846. In 1847, he took the and gone through many transformations to lease on the King Street house and quickly walls become the iconic project it is today. The first became a leading figure in London society – Sally Hales explores the history of its kind in the world, it sprang to life in his is the only plaque to have been installed ➤ of London’s ground-breaking 1866 when the (Royal) Society of Arts sought “to increase the public estimation for places Main image: Keats House in Hampstead blue plaques project as it which have been the abodes of men who Bottom, from left to right: The plaques for celebrates its 150th birthday have made England what it is”. -
Ipswich's Blue Plaques
IPSWICH’S BLUE PLAQUES The Ipswich Society JEAN INGELOW 1820 - 1897 2 Elm Street A distinguished Victorian author highly regarded by Tennyson and Ruskin, Jean Ingelow was one of the best-selling authors of poetry, children's stories and novels from 1850 until her death. However, her fame critically declined in the 20th century, though she is still celebrated in the USA. Born in Lincolnshire, Jean moved to Ipswich, aged fourteen, when her father became manager of a banking company. Living in Elm Street for ten years in the spacious first floor rooms over the bank she began her first experiments as a writer. After bank failure and the family’s departure, the arch was created and Arcade Street was built on the site of the Ingelow's garden. MARGARET TEMPEST 1892 - 1982 3 St Edmunds Road Margaret Tempest (Lady Mears) was born at 28 Fonnereau Rd Ipswich, later moving to 34 Park Rd. She attended Ipswich Art School and Westminster School of Art, graduating in 1914. She was a founder member of the Chelsea Illustrators - a society of twenty women illustrators, who successfully worked together between 1919 and 1939. Margaret is credited with the distinctive design of Alison Utley’s Little Grey Rabbit books, which she illustrated from 1929 into the 1960s. She illustrated her own books as well as those of a wide range of authors. From London, Margaret returned to Suffolk many weekends to pursue her passion of sailing. In 1939 Margaret moved permanently to the Ipswich area and married Sir Grimwood Mears. They moved to 3 St Edmunds Rd in January 1951, where Lady Mears continued living until her death. -
How England Preserves Its Cultural Heritage
MASARYK UNIVERSITY FACULTY OF EDUCATION Department of English Language and Literature How England Preserves its Cultural Heritage Bachelor thesis Brno 2018 Supervisor Author Mgr. Zdeněk Janík, M.A., Ph.D. Tomáš Češek Prohlášení Prohlašuji, že jsem závěrečnou bakalářskou práci vypracovala samostatně, s využitím pouze citovaných literárních zdrojů, dalších informací a zdrojů v souladu s Disciplinárním řádem pro studenty Pedagogické fakulty Masarykovy university a se zákonem č. 121/2000 Sb. o právu autorském, o právech souvisejících s právem autorským a o změně některých zákonů (autorský zákon), ve znění pozdějších předpisů. .................................................... Tomáš Češek Acknowledgement I would like to thank Mgr. Zdeněk Janík, M.A., Ph.D., for his valuable advice, patience, and support, and to my family. Abstract The Bachelor thesis deals with history, structure and methods of preserving England's cultural heritage. It focuses on both theoretical aspects of historic preservation as well as the practical side. The significant part of the thesis occupies with English Heritage and its activities in this sector. The first section of the thesis occupies with the theory of cultural conservation. The second part presents the historical development of historical preservation in England containing a comparison with other parts of the United Kingdom. The third part shows English Heritage as one of the most influential organisations regarding English historical preservation with laying stress on its history, development, structure and procedures. The fourth part introduces actual sites under English Heritage protection and shows the theory of preservation in practice. The final part compares the forms and promotions of historical preservation in the United Kingdom and the Czech Republic with focus on heritage marketing.