Common Name: THALLIUM SULFATE

CAS Number: 10031-59-1 RTK Substance number: 1842 DOT Number: UN 1707 Date: November 2000 Revision: May 2007 DOT Hazard Class: 6.1 (Poison) ------

HAZARD SUMMARY * If you think you are experiencing any work-related health * Thallium Sulfate can affect you when breathed in and by problems, see a doctor trained to recognize occupational passing through your skin. diseases. Take this Fact Sheet with you. * Contact can irritate the skin and eyes. * High exposure to Thallium Sulfate can cause nausea, WORKPLACE EXPOSURE LIMITS vomiting, diarrhea, salivation, headache, tremors, fatigue, The following exposure limits are for soluble Thallium weakness, confusion, convulsions, coma and death. compounds (measured as Thallium): * Repeated exposure to Thallium Sulfate can cause loss of vision, skin rash, hair loss, and joint pain. OSHA: The legal airborne permissible exposure limit * Thallium Sulfate may damage the liver and kidneys. (PEL) is 0.1 mg/m3 averaged over an 8-hour * Thallium Sulfate may damage the nervous system workshift. causing numbness, "pins and needles," and/or weakness in the hands and feet. NIOSH: The recommended airborne exposure limit is 0.1 mg/m3 averaged over a 10-hour workshift. IDENTIFICATION Thallium Sulfate is an odorless, colorless, crystalline (sand- ACGIH: The recommended airborne exposure limit is like) solid or a white powder. It is used as a rodenticide and 0.1 mg/m3 averaged over an 8-hour workshift. an insecticide. * The above exposure limits are for air levels only. When REASON FOR CITATION skin contact also occurs, you may be overexposed, even * Thallium Sulfate is on the Hazardous Substance List though air levels are less than the limits listed above. because it is regulated by OSHA and cited by ACGIH, DOT, NIOSH, DEP, IRIS and EPA. WAYS OF REDUCING EXPOSURE * Definitions are provided on page 5. * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust HOW TO DETERMINE IF YOU ARE BEING ventilation or enclosure is not used, respirators should be EXPOSED worn. * Wear protective work clothing. The New Jersey Right to Know Act requires most employers * Wash thoroughly immediately after exposure to Thallium to label chemicals in the workplace and requires public Sulfate and at the end of the workshift. employers to provide their employees with information and * Post hazard and warning information in the work area. In training concerning chemical hazards and controls. The addition, as part of an ongoing education and training federal OSHA Hazard Communication Standard (29 CFR effort, communicate all information on the health and 1910.1200) requires private employers to provide similar safety hazards of Thallium Sulfate to potentially exposed training and information to their employees. workers. * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under the OSHA Access to Employee Exposure and Medical Records Standard (29 CFR 1910.1020).

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This Fact Sheet is a summary source of information of all Any evaluation should include a careful history of past and potential and most severe health hazards that may result from present symptoms with an exam. Medical tests that look for exposure. Duration of exposure, concentration of the substance damage already done are not a substitute for controlling and other factors will affect your susceptibility to any of the exposure. potential effects described below. ------Request copies of your medical testing. You have a legal right - to this information under the OSHA Access to Employee Exposure and Medical Records Standard (29 CFR 1910.1020). HEALTH HAZARD INFORMATION Mixed Exposures Acute Health Effects * Because more than light alcohol consumption can cause The following acute (short-term) health effects may occur liver damage, drinking alcohol can increase the liver immediately or shortly after exposure to Thallium Sulfate: damage caused by Thallium Sulfate.

* Contact can irritate the skin and eyes. WORKPLACE CONTROLS AND PRACTICES * High exposure to Thallium Sulfate can cause nausea, vomiting, diarrhea, salivation, headache, tremors, fatigue, Unless a less toxic chemical can be substituted for a hazardous weakness, confusion, convulsions, coma and death. substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to Chronic Health Effects enclose operations and/or provide local exhaust ventilation at The following chronic (long-term) health effects can occur at the site of chemical release. Isolating operations can also some time after exposure to Thallium Sulfate and can last for reduce exposure. Using respirators or protective equipment is months or years: less effective than the controls mentioned above, but is sometimes necessary. Cancer Hazard * According to the information presently available to the New In evaluating the controls present in your workplace, consider: Jersey Department of Health and Senior Services, Thallium (1) how hazardous the substance is, (2) how much of the Sulfate has not been tested for its ability to cause cancer in substance is released into the workplace and (3) whether animals. harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when Reproductive Hazard significant skin, eye, or breathing exposures are possible. * Thallium Sulfate may damage the testes (male reproductive glands). In addition, the following control is recommended:

Other Long-Term Effects * Where possible, automatically transfer Thallium Sulfate * Repeated exposure to Thallium Sulfate can cause loss of from drums or other storage containers to process vision, skin rash, hair loss, and joint pain. containers. * Thallium Sulfate may damage the liver and kidneys. * Thallium Sulfate may damage the nervous system causing Good WORK PRACTICES can help to reduce hazardous numbness, "pins and needles," and/or weakness in the exposures. The following work practices are recommended: hands and feet. * Workers whose clothing has been contaminated by MEDICAL Thallium Sulfate should change into clean clothing promptly. Medical Testing * Do not take contaminated work clothes home. Family members could be exposed. For those with frequent or potentially high exposure (half the * Contaminated work clothes should be laundered by PEL or greater), the following are recommended before individuals who have been informed of the hazards of beginning work and at regular times after that: exposure to Thallium Sulfate.

* Eye wash fountains should be provided in the immediate * Liver and kidney function tests work area for emergency use.

* If there is the possibility of skin exposure, emergency If symptoms develop or overexposure is suspected, the shower facilities should be provided. following are recommended: * On skin contact with Thallium Sulfate, immediately wash

or shower to remove the chemical. At the end of the * Exam of the nervous system workshift, wash any areas of the body that may have * Vision testing contacted Thallium Sulfate, whether or not known skin contact has occurred. THALLIUM SULFATE page 3 of 6

* Do not eat, smoke, or drink where Thallium Sulfate is * If while wearing a filter or cartridge respirator you can handled, processed, or stored, since the chemical can be smell, taste, or otherwise detect Thallium Sulfate, or if swallowed. Wash hands carefully before eating, drinking, while wearing particulate filters abnormal resistance to applying cosmetics, smoking, or using the toilet. breathing is experienced, or eye irritation occurs while * Use a vacuum or a wet method to reduce dust during clean- wearing a full facepiece respirator, leave the area up. DO NOT DRY SWEEP. immediately. Check to make sure the respirator-to-face seal is still good. If it is, replace the filter or cartridge. If the PERSONAL PROTECTIVE EQUIPMENT seal is no longer good, you may need a new respirator. * Be sure to consider all potential exposures in your WORKPLACE CONTROLS ARE BETTER THAN workplace. You may need a combination of filters, PERSONAL PROTECTIVE EQUIPMENT. However, for prefilters or cartridges to protect against different forms of a some jobs (such as outside work, confined space entry, jobs chemical (such as vapor and mist) or against a mixture of done only once in a while, or jobs done while workplace chemicals. controls are being installed), personal protective equipment * Where the potential exists for exposure over 1 mg/m3 (as may be appropriate. Thallium), use a NIOSH approved supplied-air respirator with a full facepiece operated in a pressure-demand or other The OSHA Personal Protective Equipment Standard (29 CFR positive-pressure mode. For increased protection use in 1910.132) requires employers to determine the appropriate combination with an auxiliary self-contained breathing personal protective equipment for each hazard and to train apparatus operated in a pressure-demand or other positive- employees on how and when to use protective equipment. pressure mode. * Exposure to 15 mg/m3 (as Thallium), is immediately The following recommendations are only guidelines and may dangerous to life and health. If the possibility of exposure not apply to every situation. above 15 mg/m3 exists, use a NIOSH approved self- contained breathing apparatus with a full facepiece operated Clothing in a pressure-demand or other positive-pressure mode * Avoid skin contact with Thallium Sulfate. Wear equipped with an emergency escape air cylinder. protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on QUESTIONS AND ANSWERS the most protective glove/clothing material for your operation. Q: If I have acute health effects, will I later get chronic * All protective clothing (suits, gloves, footwear, headgear) health effects? should be clean, available each day, and put on before A: Not always. Most chronic (long-term) effects result from work. repeated exposures to a chemical.

Eye Protection Q: Can I get long-term effects without ever having short- * Wear eye protection with side shields or goggles. term effects? * Wear a face shield along with goggles when working with A: Yes, because long-term effects can occur from repeated corrosive, highly irritating or toxic substances. exposures to a chemical at levels not high enough to make you immediately sick. Respiratory Protection IMPROPER USE OF RESPIRATORS IS DANGEROUS. Q: What are my chances of getting sick when I have been Such equipment should only be used if the employer has a exposed to chemicals? written program that takes into account workplace conditions, A: The likelihood of becoming sick from chemicals is requirements for worker training, respirator fit testing, and increased as the amount of exposure increases. This is medical exams, as described in the OSHA Respiratory determined by the length of time and the amount of Protection Standard (29 CFR 1910.134). material to which someone is exposed.

* For field applications check with your supervisor and your Q: When are higher exposures more likely? safety equipment supplier regarding the appropriate A: Conditions which increase risk of exposure include dust respiratory equipment. releasing operations (grinding, mixing, blasting, dumping, * Where the potential exists for exposure over 0.1 mg/m3 (as etc.), other physical and mechanical processes (heating, Thallium), use a NIOSH approved air-purifying, particulate pouring, spraying, spills and evaporation from large filter respirator with a N95 filter. More protection is surface areas such as open containers), and "confined provided by a full facepiece respirator than by a half-mask space" exposures (working inside vats, reactors, boilers, respirator, and even greater protection is provided by a small rooms, etc.). powered-air purifying respirator. THALLIUM SULFATE page 4 of 6

Q: Is the risk of getting sick higher for workers than for ------community residents? The following information is available from: A: Yes. Exposures in the community, except possibly in cases of fires or spills, are usually much lower than those New Jersey Department of Health and Senior Services found in the workplace. However, people in the Occupational Health Service community may be exposed to contaminated water as well PO Box 360 as to chemicals in the air over long periods. This may be Trenton, NJ 08625-0360 a problem for children or people who are already ill. (609) 984-1863 (609) 984-7407 (fax) Q: Can men as well as women be affected by chemicals that cause reproductive system damage? Web address: http://www.state.nj.us/health/eoh/odisweb/ A: Yes. Some chemicals reduce potency or fertility in both men and women. Some damage sperm and eggs, possibly Industrial Hygiene Information leading to birth defects. Industrial hygienists are available to answer your questions regarding the control of chemical exposures using exhaust Q: Who is at the greatest risk from reproductive hazards? ventilation, special work practices, good housekeeping, good A: Pregnant women are at greatest risk from chemicals that hygiene practices, and personal protective equipment including harm the developing fetus. However, chemicals may respirators. In addition, they can help to interpret the results of affect the ability to have children, so both men and industrial hygiene survey data. women of childbearing age are at high risk. Medical Evaluation If you think you are becoming sick because of exposure to chemicals at your workplace, you may call personnel at the Department of Health and Senior Services, Occupational Health Service, who can help you find the information you need.

Public Presentations Presentations and educational programs on occupational health or the Right to Know Act can be organized for labor unions, trade associations and other groups.

Right to Know Information Resources The Right to Know Infoline (609) 984-2202 can answer questions about the identity and potential health effects of chemicals, list of educational materials in occupational health, references used to prepare the Fact Sheets, preparation of the Right to Know Survey, education and training programs, labeling requirements, and general information regarding the Right to Know Act. Violations of the law should be reported to (609) 984-2202. ------

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DEFINITIONS

ACGIH is the American Conference of Governmental NAERG is the North American Emergency Response Industrial Hygienists. It recommends upper limits (called Guidebook. It was jointly developed by Transport Canada, the TLVs) for exposure to workplace chemicals. United States Department of Transportation and the Secretariat of Communications and Transportation of Mexico. It is a A carcinogen is a substance that causes cancer. guide for first responders to quickly identify the specific or generic hazards of material involved in a transportation The CAS number is assigned by the Chemical Abstracts incident, and to protect themselves and the general public Service to identify a specific chemical. during the initial response phase of the incident.

CFR is the Code of Federal Regulations, which consists of the NFPA is the National Fire Protection Association. It classifies regulations of the United States government. substances according to their fire and explosion hazard.

A combustible substance is a solid, liquid or gas that will burn. NIOSH is the National Institute for Occupational Safety and Health. It tests equipment, evaluates and approves respirators, A corrosive substance is a gas, liquid or solid that causes conducts studies of workplace hazards, and proposes standards irreversible damage to human tissue or containers. to OSHA.

DEP is the New Jersey Department of Environmental NTP is the National Toxicology Program which tests Protection. chemicals and reviews evidence for cancer.

DOT is the Department of Transportation, the federal agency OSHA is the Occupational Safety and Health Administration, that regulates the transportation of chemicals. which adopts and enforces health and safety standards.

EPA is the Environmental Protection Agency, the federal PEL is the Permissible Exposure Limit which is enforceable by agency responsible for regulating environmental hazards. the Occupational Safety and Health Administration.

A fetus is an unborn human or animal. PIH is a DOT designation for chemicals which are Poison Inhalation Hazards. A flammable substance is a solid, liquid, vapor or gas that will ignite easily and burn rapidly. ppm means parts of a substance per million parts of air. It is a measure of concentration by volume in air. The flash point is the temperature at which a liquid or solid gives off vapor that can form a flammable mixture with air. A reactive substance is a solid, liquid or gas that releases energy under certain conditions. IARC is the International Agency for Research on Cancer, a scientific group that classifies chemicals according to their STEL is a Short Term Exposure Limit which is usually a 15- cancer-causing potential. minute exposure that should not be exceeded at any time during a work day. IRIS is the Integrated Risk Information System database of the federal EPA. A teratogen is a substance that causes birth defects by damaging the fetus. A miscible substance is a liquid or gas that will evenly dissolve in another. TLV is the Threshold Limit Value, the workplace exposure limit recommended by ACGIH. mg/m3 means milligrams of a chemical in a cubic meter of air. It is a measure of concentration (weight/volume). The vapor pressure is a measure of how readily a liquid or a solid mixes with air at its surface. A higher vapor pressure A mutagen is a substance that causes mutations. A mutation is indicates a higher concentration of the substance in air and a change in the genetic material in a body cell. Mutations can therefore increases the likelihood of breathing it in. lead to birth defects, miscarriages, or cancer.

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Common Name: THALLIUM SULFATE HANDLING AND STORAGE DOT Number: UN 1707 DOT Hazard Class: 6.1 (Poison) * Prior to working with Thallium Sulfate you should be NAERG Code: 151 trained on its proper handling and storage. CAS Number: 10031-59-1 * Thallium Sulfate is not compatible with OXIDIZING AGENTS (such as PERCHLORATES, PEROXIDES, PERMANGANATES, CHLORATES, NITRATES,

Hazard rating NJDHSS NFPA CHLORINE, BROMINE and FLUORINE); NITRIC FLAMMABILITY 0 - ACID; and SULFURIC ACID. * Store in tightly closed containers in a cool, well-ventilated REACTIVITY 0 - area. DOES NOT BURN

POISONOUS GASES ARE PRODUCED IN FIRE FIRST AID

Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; For POISON INFORMATION call 1-800-222-1222 3=serious; 4=severe

Eye Contact FIRE HAZARDS * Immediately flush with large amounts of water for at least

15 minutes, occasionally lifting upper and lower lids. * Extinguish fire using an agent suitable for type of

surrounding fire. Thallium Sulfate itself does not burn. Skin Contact * POISONOUS GASES ARE PRODUCED IN FIRE, * Remove contaminated clothing. Wash contaminated skin including Sulfur Oxides and Thallium fumes. with soap and water. * If employees are expected to fight fires, they must be

trained and equipped as stated in the OSHA Fire Brigades Breathing Standard (29 CFR 1910.156). * Remove the person from exposure.

SPILLS AND EMERGENCIES * Begin rescue breathing (using universal precautions) if breathing has stopped and CPR if heart action has stopped.

* Transfer promptly to a medical facility. If Thallium Sulfate is spilled, take the following steps:

PHYSICAL DATA * Evacuate personnel and secure and control entrance to the area. o o * Collect powdered material in the most convenient and safe Vapor Pressure: 0 mm Hg at 68 F (20 C) manner and deposit in sealed containers. Water Solubility: Soluble * Ventilate and wash area after clean-up is complete. * It may be necessary to contain and dispose of Thallium OTHER COMMONLY USED NAMES Sulfate as a HAZARDOUS WASTE. Contact your state Department of Environmental Protection (DEP) or your This fact sheet also covers: regional office of the federal Environmental Protection Thallous Sulfate CAS # 7446-18-6 RTK # 2887 Agency (EPA) for specific recommendations. * If employees are required to clean-up spills, they must be Chemical Name: properly trained and equipped. The OSHA Hazardous Sulfuric Acid, Dithallium (1+) Salt Waste Operations and Emergency Response Standard (29 Other Names: CFR 1910.120) may apply. Eccothal; Dithallium Sulfate; CFS

======------FOR LARGE SPILLS AND FIRES immediately call your fire -- department. You can request emergency information from the Not intended to be copied and sold for commercial following: purposes. ------CHEMTREC: (800) 424-9300 -- NJDEP HOTLINE: 1-877-WARN-DEP NEW JERSEY DEPARTMENT OF HEALTH AND ======SENIOR SERVICES Right to Know Program PO Box 368, Trenton, NJ 08625-0368 (609) 984-2202 page 7 of 6 >>>>>>>>>>>>>>>>> E M E R G E N C Y I N F O R M A T I O N <<<<<<<<<<<<<<<<<

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