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Utilising the Intel Realsense Camera for Measuring Health Outcomes in Clinical Research

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Utilising the Intel Realsense Camera for Measuring Health Outcomes in Clinical Research Journal of Medical Systems (2018) 42:53 https://doi.org/10.1007/s10916-018-0905-x MOBILE & WIRELESS HEALTH Utilising the Intel RealSense Camera for Measuring Health Outcomes in Clinical Research Francesco Luke Siena1 & Bill Byrom2 & Paul Watts1 & Philip Breedon1 Received: 12 January 2018 /Accepted: 18 January 2018 # The Author(s) 2018. This article is an open access publication Abstract Applications utilising 3D Camera technologies for the measurement of health outcomes in the health and wellness sector continues to expand. The Intel® RealSense™ is one of the leading 3D depth sensing cameras currently available on the market and aligns itself for use in many applications, including robotics, automation, and medical systems. One of the most prominent areas is the production of interactive solutions for rehabilitation which includes gait analysis and facial tracking. Advancements in depth camera technology has resulted in a noticeable increase in the integration of these technologies into portable platforms, suggesting significant future potential for pervasive in-clinic and field based health assessment solutions. This paper reviews the Intel RealSense technology’s technical capabilities and discusses its application to clinical research and includes examples where the Intel RealSense camera range has been used for the measurement of health outcomes. This review supports the use of the technology to develop robust, objective movement and mobility-based endpoints to enable accurate tracking of the effects of treatment interventions in clinical trials. Keywords 3D Depth Camera . Intel® RealSense™ . Motion Capture . Clinical Trials . Health Outcomes Introduction wellbeing applications or clinical and healthcare research. The rapid development of 3D camera technologies has result- There are an increasing number of 3D camera-based technol- ed in a market with numerous options, all with varying ogies in today’s market generating a large number of techno- strengths and weaknesses. Therefore, camera selection is crit- logical solutions in many different sectors. Finding a unique ical dependant on the desired application. Some of the most application is therefore becoming even more difficult whether notable solutions include the Microsoft® Kinect™1 Sensor it be related to 3D scanning, motion capture, gaming, V1/1.0 (360), Microsoft Kinect Sensor V2/2.0 (One) (Microsoft Corp., Redmond, Washington, USA), Intel RealSense 3D Camera range, Intel® Euclid™ (Intel Corp., © Intel Corporation, Santa Clara, California, USA, https://www.intel.com Santa Clara, CA, USA), Creative Senz3D (Creative This article is part of the Topical Collection on Mobile & Wireless Health Technology Ltd., Singapore) Asus Xtion Pro Live (AsusTek Computer Inc., Beitou District, Taipei, Taiwan), OptiTrack * Philip Breedon MoCap (NaturalPoint, Inc., USA), Vicon Infineon 3D Image [email protected]; https://www.ntu.ac.uk/ Sensor (REAL3™ Gesture Control) (Vicon Motion Systems Ltd., Oxford, UK) and ZED Stereo Camera (Stereolabs Inc. FrancescoLukeSiena [email protected]; https://www.ntu.ac.uk/ San Francisco, CA, USA). The Intel RealSense is one of the most prominent 3D depth Bill Byrom [email protected]; https://www.iconplc.com sensing cameras available, and especially now, considering the recent announcement that manufacture of the Microsoft Paul Watts Kinect Sensor V2/2.0 has now ceased - potentially signalling [email protected]; https://www.ntu.ac.uk/ the end of Microsoft’s involvement in this technology sector 1 Medical Design Research Group, Nottingham Trent University, Nottingham NG1 4FQ, UK 1 Microsoft ® Corporation, Redmond, Washington, USA, https://www. 2 Product Innovation, ICON Clinical Research, Marlow SL7 1YL, UK microsoft.com 53 Page 2 of 10 J Med Syst (2018) 42:53 [1]. Although Kinect support will continue to exist in the platforms including PC’s, laptops, 2-1 Laptop/PC’s, external interim for the motion-sensing device, the limited access to camera systems, smartphones and tablets. purchase this technology will likely signal a change in the A number of the capabilities of these camera systems, and adoption and use of this motion sensing device for new devel- those produced by other manufacturers are particularly impor- opment applications. tant to consider when creating applications for clinical re- search; a selection of these are described in Table 1. Application to clinical research All of the 3D camera’s that utilise Intel's RealSense software development kits (SDKs) enable the development of natural, There are numerous applications utilising motion capture immersive, and intuitive software applications utilising routines technology to study or encourage movement in wellness, that include but that are not limted to, facial recognition, hand healthcare and clinical research. Much of this work has been gesture, background removal, 3D scanning and skeletal tracking. accomplished in the area of rehabilitation to provide an en- Another recent addition to the market is the Intel Euclid™ gaging environment through which to conduct a regular exer- Development Kit. This utilises an Ubuntu® (Canonical Ltd., cise regimen. This enables patient feedback and correction to London, UK) operating system integrated with Intel RealSense ensure that exercises are being performed correctly for optimal depth camera technology in combination with an Intel® Atom™ benefit, and enables remote assessment and adjustment of ex- ×7-Z8700 Quad Core CPU providing a compact and sleek all-in- ercise regimens between clinic visits [2]. one computer and depth camera system [3]. In clinical research and clinical drug development, the study of movement and mobility can be a vital component Facial tracking of understanding the impact of an intervention. This is typi- cally assessed by clinician rating or using an instrumented The Intel RealSense camera range can be used to scan and solution to provide an objective measurement. Many instru- track facial features and gestures with and without facial hair mented solutions to assess motion and mobility, such as the and glasses. It has the ability to 3D track up to 78 facial Vicon 3D motion analysis system (Vicon Motion Systems landmark points that can support avatar creation, emotion rec- Ltd., Oxford, UK) or the GAITRite™ pressure pad system ognition and facial animation [4]. The Intel RealSense can (CIR systems Inc., Franklin, NJ, USA) are expensive to use also detect head orientation along 3D axes for yaw, pitch and may be confined to specialist assessment centres, limiting and roll. Depending on the camera in use the ability to track their use in large-scale clinical trials. up to four faces with marked rectangles for face boundaries is Low-cost, reliable 3D camera technology may provide a achievable. For systems where the environment cannot be means to collect rich objective data in non-specialist centres in controlled this is extremely useful as it would allow the indi- large clinical trials. Application areas may include: assessment vidual patient to be identified and solely tracked. The Intel of gait and upper extremity movement (e.g., in stroke pa- RealSense camera range can offer greater resolution and sam- tients); walking, upper extremity and dexterity tests (e.g., in pling rates compared to some of the current market leaders, multiple sclerosis); walking, posture and balance testing (e.g., including the Microsoft Kinect 2.0. The greater resolution and in Parkinson’s disease); and other indications or side-effects sampling rate offer advantages when tracking fine or fast where objective measures of movement or mobility are im- movements. portant to how patient’s function such as: amyotrophic lateral sclerosis, tardive dyskinesia, Huntington disease, depression Skeletal tracking (where gait is indicative of mood status), restless leg syn- drome, Bell’s (facial) palsy, muscular dystrophies and rheu- The Intel RealSense can also perform skeletal tracking. By matoid diseases amongst many others. tracking the 3D coordinates of body joints, the Intel RealSense can create a virtual skeleton allowing the calcula- tion of patient movement parameters and joint angles. This Properties of the Intel RealSense camera real-time tracking enables the development of applications in relevant to clinical research applications a number of key areas. Tracking a user’sskeletalmovement during a routine exercise or while playing a game opens up the The Intel® RealSense™ camera utilises a variety of sensing ability to detect subtle improvements during rehabilitation technologies to achieve depth perception, 3D imaging, interior from injury or stroke. In the past this has been done by placing mapping, and feature tracking. Intel present a variety of uses sensors on the user’s body at key locations, or using complex for the Intel® RealSense™, which considers virtual reality, multi-camera systems, and the transmitting data to a connect- robotic vision development, drones, security, 3D scanning ed machine for analysis. These setups are often expensive, and tracking, amongst others. Intel have developed a range inconvenient and difficult to use in non-specialist settings. In of camera systems which can be integrated into a variety of addition, joint tracking can enable the measurement of body J Med Syst (2018) 42:53 Page 3 of 10 53 Table 1 3D camera system properties for consideration when developing clinical research applications Property Rationale Field of vision Field and depth of vision define the working area in which the tracking of patient
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