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Arjuna Award Winners from All Categories Year Category Name
OLYMPIC DREAM INDIA Arjuna Award Winners from All Categories Year Category Name 2016 Boxing Shiva Thapa 2016 Billiards & Sourav Kothari Snooker 2016 Athletics Lalita Shivaji Babar 2016 Cricket Ajinkya Rahane 2015 Gymnastics Dipa Karmakar 2015 Kabaddi Abhilasha Shashikant Mhatre 2015 Rowing Sawarn Singh 2015 Weightlifting Sathish Kumar Sivalingam 2015 Boxing Mandeep Jangra 2015 Athletics Machettira Raju Poovamma 2015 Archery Naib Subedar Sandeep Kumar 2015 Shooting Jitu Rai 2015 Kabaddi Manjeet Chhillar 2015 Cricket Rohit Sharma 2015 Wrestling Bajrang Kumar 1 OLYMPIC DREAM INDIA 2015 Wrestling Babita Kumari 2015 Wushu Yumnam Sanathoi Devi 2015 Swimming Sharath M. Gayakwad (Paralympic Swimming) 2015 RollerSkating Anup Kumar Yama 2015 Badminton Kidambi Srikanth Nammalwar 2015 Hockey Parattu Raveendran Sreejesh 2014 Weightlifting Renubala Chanu 2014 Archery Abhishek Verma 2014 Athletics Tintu Luka 2014 Cricket Ravichandran Ashwin 2014 Kabaddi Mamta Pujari 2014 Shooting Heena Sidhu 2014 Rowing Saji Thomas 2014 Wrestling Sunil Kumar Rana 2014 Volleyball Tom Joseph 2014 Squash Anaka Alankamony 2014 Basketball Geetu Anna Jose 2 OLYMPIC DREAM INDIA 2014 Badminton Valiyaveetil Diju 2013 Hockey Saba Anjum 2013 Golf Gaganjeet Bhullar 2013 Athletics Ranjith Maheshwari (Athlete) 2013 Cricket Virat Kohli 2013 Archery Chekrovolu Swuro 2013 Badminton Pusarla Venkata Sindhu 2013 Billiards & Rupesh Shah Snooker 2013 Boxing Kavita Chahal 2013 Chess Abhijeet Gupta 2013 Shooting Rajkumari Rathore 2013 Squash Joshna Chinappa 2013 Wrestling Neha Rathi 2013 Wrestling Dharmender Dalal 2013 Athletics Amit Kumar Saroha 2012 Wrestling Narsingh Yadav 2012 Cricket Yuvraj Singh 3 OLYMPIC DREAM INDIA 2012 Swimming Sandeep Sejwal 2012 Billiards & Aditya S. Mehta Snooker 2012 Judo Yashpal Solanki 2012 Boxing Vikas Krishan 2012 Badminton Ashwini Ponnappa 2012 Polo Samir Suhag 2012 Badminton Parupalli Kashyap 2012 Hockey Sardar Singh 2012 Kabaddi Anup Kumar 2012 Wrestling Rajinder Kumar 2012 Wrestling Geeta Phogat 2012 Wushu M. -
List of I.R.W.O Membership Number
List of I.R.W.O Membership Number Sl.No. Membership Name Gurdian Name Date of Receipt Date No. Birth in IRWO 4131 204130 Rajnesh Singh Raghunath Singh 18-Sep-76 2-Jan-12 4132 204131 Ashok Kumar Singh Jogindar Singh 21-Mar-41 13-Jan-11 4133 204132 L. Vijayan S. Loganathan 18-Jul-73 2-Jan-12 4134 204133 Devidatta Satapathy Dhruba Charan Satpathy 27-Jul-80 2-Jan-12 4135 204134 Gauri Shanker Basti Ram 1-Jul-56 2-Jan-12 4136 204135 Kamal Prakash Srivastava Mata Prasad Srivastava 21-Jan-61 3-Jan-12 4137 204136 Bal Mukund Ram Lukhaya 1-Oct-27 4-Jan-12 4138 204137 Sandeep Sharma Rajender Sharma 30-Sep-66 4-Jan-12 4139 204138 Mukesh Kumar Vijay Om Parkash 30-Apr-70 5-Jan-12 4140 204139 A. Simon S. Antony Raj 28-Apr-80 5-Jan-12 4141 204140 Ramgopal Liladhar 10-Jul-66 9-Jan-12 4142 204141 Ramnagina Yadav Bindeshwari 26-Mar-68 9-Jan-12 4143 204142 Rampravesh Singh Zuri Singh 17-Nov-54 11-Jan-12 4144 204143 Vishwa Prakash M. Sardar Singh Kulshreshtha 7-Aug-24 13-Jan-12 4145 204144 Shibdhar Singh Adhik Narain Singh 11-Jul-44 13-Jan-12 4146 204145 Alip Sarkar Nityananda Sarkar 1-Dec-74 16-Jan-12 4147 204146 Swapna Chatterjee Purnendu Chatterjee 27-Nov-52 16-Jan-12 4148 204147 Pitabasa Nayak B. Nayak 12-Mar-70 17-Jan-12 4149 204148 Sisir Kumar Saha Suryya Kanta Saha 1-Mar-32 17-Jan-12 4150 204149 Sudhir Kumar Goel Atma Ram Goel 30-Jun-51 17-Jan-12 4151 204150 Rajesh Kumar Atal Kewal Ram Atal 3-Sep-80 17-Jan-12 4152 204151 K . -
W Part No Serial H No Name F Name Sex Age W Name Address 5 1 96 B 11 B Pamanpreet Kaur Charanjeet Singh F 29 Model Town D Block
W PART NO SERIAL H NO NAME F NAME SEX AGE W NAME ADDRESS 5 1 96 B 11 B PAMANPREET KAUR CHARANJEET SINGH F 29 MODEL TOWN D BLOCK MODEL TOWN 5 1 123 B 31 B HARPREET KAUR KULDEEP SINGH F 27 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 124 B 31 B DALIP KAUR PRITAM SINGH F 73 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 153 B 52 A HARVINDER KAUR HARJEET SINGH F 49 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 155 B 52 A HARJEET SINGH ROSHAN SINGH M 53 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 156 B 52 A HARMANDER SINGH HARJEET SINGH M 44 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 157 B 52 A AMAR JEET SINGH HARJEET SINGH M 29 MODEL TOWN B BLOCK VIJAY NAGAR 5 1 295 E 7 SIMARAN KAUR RAJINDER PAL SINGH F 45 MODEL TOWN E BLOCK VIJAY N 5 1 343 F 29 A SAWARAN SINGH SUDNER SINGH M 75 MODEL TOWN E BLOCK VIJAY N 5 1 377 G 6 A SURPREET SINGH KANWAL SINGH SARAN M 31 MODEL TOWN E BLOCK VIJAY N 5 1 379 G 6 A DIPTI KAUR KAMAL SINGH SARAN F 34 MODEL TOWN E BLOCK VIJAY N 5 1 385 G 7 A PRAJEET KAUR MAN MOHAN SINGH F 43 MODEL TOWN E BLOCK VIJAY N 5 1 400 G 11 NARANDER KAUR SURNDER SINGH F 58 MODEL TOWN E BLOCK VIJAY N 5 1 402 G 11 BALBIR SINGH PRADUMAN SINGH M 49 MODEL TOWN E BLOCK VIJAY N 5 1 403 G 11 AMART KAUR B S MAKAN F 45 MODEL TOWN E BLOCK VIJAY N 5 1 405 G 11 SILVERJEET SINGH BALBIR SINGH M 28 MODEL TOWN E BLOCK VIJAY N 5 1 406 G 11 MAHINDER SINGH SURINDER SINGH M 54 MODEL TOWN E BLOCK VIJAY N 5 1 407 G 11 RAJINDER SINGH SURINDER SINGH M 26 MODEL TOWN E BLOCK VIJAY N 5 1 446 G 18 TEJANDER KAUR AMAR JEET SINGH F 56 MODEL TOWN E BLOCK VIJAY N 5 1 447 G 18 JASPAL SINGH AMAR JEET SINGH M 35 MODEL TOWN -
List of Dealers Having Mismatch Name Regarding Pans
STATE DATA CBDT DATA CBDT DATA After removing initial MNAME_I SNO TIN PAN_UPDATED DEPT_PROP_NAME TRADE_NAME PAN_PK FNAME MNAME SNAME FNAME_INITIAL NITIAL SNAME_INITIAL 1 4020024033 AFQPG5778L ARUN GOYAL JAI AMBIKA MEDICOS AFQPG5778L VINIT - GOEL VINIT - GOEL 2 4060004708 ADJPA2312F SHAM LAL SHAM LAL & SONS ADJPA2312F SHAM LAL ANAND SHAM LAL ANAND 3 4060007230 ADZPD6506G SURINDER PAL SINGH DUA TRADING CO. ADZPD6506G SURINDER PAL SINGH DUA SURINDER PAL SINGH DUA ASHA 4 4060015572 ADPPD7262F SANDEEP PHARMACEUTICALS ADPPD7262F SANDEEP DHAM SANDEEP DHAM M.S. ENGINEERING 5 4060017124 AAQPA0056L M M ARORA PRODUCTS AAQPA0056L MADAN MOHAN ARORA MADAN MOHAN ARORA AMBAJI MARBLE & 6 4070020756 AEVPB2731A SANJAY KUMAR GRANITE AEVPB2731A SANJAY KUMAR BANSAL SANJAY KUMAR BANSAL 7 4090024043 CGCPS4112H SUNITA JAIN SANMATI INDUSTRIES CGCPS4112H SUNITA SUNITA 8 4100018654 ABAPK2944E ASHOK KUMAR KAPOOR AGENCIES ABAPK2944E ASHOK KUMAR KAPOOR ASHOK KUMAR KAPOOR OM TRADING 9 4100034174 ALEPK7794G PREM KUMAR BANSAL COMPANY ALEPK7794G PREM - KUMAR PREM - KUMAR 10 4100034271 AGTPG8878R PARAS KUMAR DAYA PHARMA AGTPG8878R SNEH GOYAL SNEH GOYAL 11 4110020346 AOYPK8080N SARAB KUMAR LACONI AEON AOYPK8080N SARAD KUMAR SARAD KUMAR RAKESH KUMAR 12 4120011853 ABGPK9238D SINGLA SINGLA ENTERPRISES ABGPK9238D RAKESH - KUMAR RAKESH - KUMAR VINAYAK 13 4120021941 ACUPK1924H VIJAY KUMR ENTERPRISES ACUPK1924H VIJAY KUMAR KOTRU VIJAY KUMAR KOTRU 14 4120023881 ABQPA7531H SH VINOD ANAND LIFE PRINTER ABQPA7531H POONAM ANAND POONAM ANAND RAKESH AUTO 15 4140016304ADIPS0362G RAKESH -
(Public Section) Padma Awards Directory (1954-2009) Year-Wise List Sl
MINISTRY OF HOME AFFAIRS (Public Section) Padma Awards Directory (1954-2009) Year-Wise List Sl. Prefix First Name Last Name Award State Field Remarks 1954 1 Dr. Sarvapalli Radhakrishnan BR TN Public Affairs Expired 2 Shri Chakravarti Rajagopalachari BR TN Public Affairs Expired 3 Dr. Chandrasekhara Raman BR TN Science & Eng. Expired Venkata 4 Shri Nand Lal Bose PV WB Art Expired 5 Dr. Satyendra Nath Bose PV WB Litt. & Edu. 6 Dr. Zakir Hussain PV AP Public Affairs Expired 7 Shri B.G. Kher PV MAH Public Affairs Expired 8 Shri V.K. Krishna Menon PV KER Public Affairs Expired 9 Shri Jigme Dorji Wangchuk PV BHU Public Affairs 10 Dr. Homi Jehangir Bhabha PB MAH Science & Eng. Expired 11 Dr. Shanti Swarup Bhatnagar PB UP Science & Eng. Expired 12 Shri Mahadeva Iyer Ganapati PB OR Civil Service 13 Dr. J.C. Ghosh PB WB Science & Eng. Expired 14 Shri Maithilisharan Gupta PB UP Litt. & Edu. Expired 15 Shri Radha Krishan Gupta PB DEL Civil Service Expired 16 Shri R.R. Handa PB PUN Civil Service Expired 17 Shri Amar Nath Jha PB UP Litt. & Edu. Expired 18 Shri Malihabadi Josh PB DEL Litt. & Edu. 19 Dr. Ajudhia Nath Khosla PB DEL Science & Eng. Expired 20 Shri K.S. Krishnan PB TN Science & Eng. Expired 21 Shri Moulana Hussain Madni PB PUN Litt. & Edu. Ahmed 22 Shri V.L. Mehta PB GUJ Public Affairs Expired 23 Shri Vallathol Narayana Menon PB KER Litt. & Edu. Expired Wednesday, July 22, 2009 Page 1 of 133 Sl. Prefix First Name Last Name Award State Field Remarks 24 Dr. -
Final ELIGIBILITY Male 11-12
DIRECTORATE OF EDUCATION (ESTT.-II BRANCH) FINAL ELIGIBILITY LIST FOR PROMOTION TO THE POST OF LECTURER (AGRICULTURE) MALE 2011-12 S.No. Employee Employee Name Date of Birth School ID School Name Present Post SENIORITY BLOCK Date of Date of REMARKS ID NO. YEAR appointment acquiring to the post of Qualification TGT for the post of Lecturer UR NO CANDIDATE SC 1 20051829 RAJENDRA PRASAD 01-May-64 1106119 GBSSS A-BLK, NAND TGT S.ST. 9672 2003-09 31-Oct-92 1988 NAGRI ST NO CANDIDATE Page 1 of 249 DIRECTORATE OF EDUCATION (ESTT.-II BRANCH) FINAL ELIGIBILITY LIST FOR PROMOTION TO THE POST OF LECTURER (BIOLOGY) MALE 2011-12 S.No. Employee Employee Name Date of Birth School ID School Name Present Post SENIORITY BLOCK Date of Date of REMARKS ID NO. YEAR appointment acquiring to the post of Qualification TGT for the post of Lecturer UR 1 19831638 DHIRENDRA RAJ 01-Jan-55 1002007 East Vinod Nagar-SBV (Jai TGT N.SC. 929 1981-85 3-Nov-1983 16-Sep-78 Prakash Narayan) 2 19910899 BIKRAM SINGH 30-Apr-62 1106002 Dilshad Garden, Block C- TGT N.SC. 3850 1986-92 1-Oct-1991 30-Jun-84 SBV 3 19911129 DHYAN SINGH 25-Mar-67 2128008 Rani Jhansi Road-SBV TGT N.SC. 3854 1986-92 28-Oct-1991 4-Aug-89 ECONOMICS BHATI ALSO 4 19911176 PRABHAKAR 24-Feb-56 1104020 Gokalpuri-SKV TGT N.SC. 3855 1986-92 19-Nov-1991 31-Dec-81 CHANDRA AWASTHI 5 19910662 VINAY KUMAR 09-Nov-63 1002004 Shakarpur, No.2-SBV TGT N.SC. -
India's Higher Defence Organisation
India’s Higher Defence Organisation: Implications for National Security and Jointness Arun Prakash INTRODUCTION In the minds of the average person on the street, one suspects that the phrase “higher defence organization” evokes an intimidating vision of row upon row of be-medalled and be-whiskered Generals, with the dark shadowy figure of a “soldier on horseback” (that mythical usurper of power) looming in the background. Too complex and dreadful to contemplate, they shut this vision out of their minds, and revert to the mundane, with which they feel far more comfortable. It is for this specific reason that in the title of this paper “National Security” has been added to “Higher Defence Organization.” Not that our comprehension of “National Security” is very much better; and in this context, just one example will suffice. Soon after the July 2006 serial train blasts in Mumbai, which resulted in over 200 dead and over 700 injured, as Chief of Naval Staff (CNS), I attended a very high level inter-agency meeting of functionaries to discuss this issue. After the presentations, discussions and brain-storming lasting a couple of hours, a final question was asked -- what urgent remedial and precautionary measures should we take to prevent recurrence of such incidents? After a pregnant silence, the sole suggestion that was voiced, shook me to the core, because of the pedestrian and worm’s eye perspective that it demonstrated: “We must give the SHOs at the thana level more and better quality walkie-talkie sets to ensure faster communications.” And this, after the nation has been experiencing bomb blasts or terrorist attacks with monotonous regularity in the wake of the horrifying 1993 Mumbai carnage; Parliament (2001), Akshardham (2002), Mumbai (2003), Ayodhya (2005), Varanasi (2006), Hyderabad (2007) and many others. -
ALL INDIA INSTITUTE of MEDICAL SCIENCES Ansari Nagar, New Delhi - 110608
ALL INDIA INSTITUTE OF MEDICAL SCIENCES Ansari Nagar, New Delhi - 110608 ALL INDIA ENTRANCE EXAMINATION FOR ADMISSION TO MD/MS/DIPLOMA AND MDS COURSES - 2011 RESULT NOTIFICATION NO. 14/2011 The following is the list of candidates who have qualified for MD/MS/Diploma and MDS courses for admission to various Medical/Dental Colleges/Institutions in India against 50% seats quota on the basis of All India Entrance Examination held on Sunday, the 9th January, 2011. In pursuance to Directorate General of Health Services (Medical Examination Cell) Letter No. U-12021/29/2010-MEC dated 11th Feb., 2011, the list is category and roll number wise and the respective category rank is given in parenthesis against each roll number. The admission is subject to verification of eligibility criteria & original documents as given in the Prospectus. The Institute is not responsible for any printing error. The allocation of subject and Medical College will be done by the Directorate General of Health Services as per revised counselling schedule available on website of Ministry of Health & Family Welfare namely www.mohfw.nic.in. Individual intimation in this respect is being sent separately. Result is displayed on the notice board of Examination Section, AIIMS, New Delhi and is also available on web sites www.aiims.ac.in, www.aiims.edu and www.aiimsexams.org which include category and over all rank of the candidates. MD/MS/DIPLOMA COURSES Roll No. Name Category Over all Rank Category Rank 1100002 Harsh Jayantkumar Shah UR 1643 1619 1100006 Senthilnathan M UR -
BIO DATA ADMIRAL ARUN PRAKASH, PVSM, AVSM, Vrc
BIO DATA ADMIRAL ARUN PRAKASH, PVSM, AVSM, VrC, VSM (Retd) Admiral Arun Prakash served as India’s 20th Naval Chief and Chairman Chiefs of Staff. An aviator by specialisation, during his 40 year career, he commanded a carrier-borne fighter-squadron, a naval air station and four warships; including the aircraft-carrier INS Viraat. He has also logged over 2500 hours in fighters, patrol aircraft and helicopters. In flag rank he commanded the Eastern Fleet, the National Defence Academy, the Andaman & Nicobar Joint Command and the Western Naval Command. On staff, he served as the head of the Aviation and Personnel Branches of the navy and as the Vice Chief of Naval Staff. During his tenure at the helm, the navy saw many initiatives being launched in the fields of doctrine, strategy, transformation and foreign maritime cooperation. He is a graduate of the IAF Test Pilots School, Defence Services Staff College and the US Naval War College. During the 1971 War, he was awarded the Vir Chakra while flying with an IAF fighter squadron in the Punjab. Post-retirement, he served two terms as a member of the National Security Advisory Board and was Chairman of the National Maritime Foundation. He served on the 1999 Arun Singh Task force as well as the Naresh Chandra Committee on national security reforms. He lives in Goa, and writes and speaks on strategic and security related topics. The Admiral holds the distinguished chair at the college and is the guiding light for research carried out by faculty and course participants. . -
Selected Candidates for 12Th Batch.Pdf
Punjab Security Training Institute, Jahan Khelan Selected Candidates for 12th Basic Security Training Course Commencing W.E.F 31.07.2011 Sr. ID Candidate Father's Mother's Address District No. No. Name Name Name 1 1 Jagseer Singh Manjeet Singh Rajinder Kaur Vpo. Kanjla, Tehsil Dhuri Sangrur 2 2 Karnail Singh Bhura Singh Amarjit Kaur VPO. Loha khera Sangrur 3 3 Sharanjeet Magh Singh Gurmail Kaur # 120. ward no. 11A, Moh. Sangrur Singh Shivpuri, near FCI Godown, Dhuri, Tehsil. Dhuri 4 4 Harjinder Tara Singh Baljinder Vill. Belewal (Darogewal) Po. Sangrur Singh Kaur Banbhora Tehsil Dhuri 5 5 Parminder Kulwinder Harminder Ramnagar W.no.5 Sunam Sangrur Singh Singh Kaur 6 6 Jasvir Singh Shingara Manjeet Kaur H.no.14,VPO. Loha khera Sangrur Singh 7 7 Jagseer Singh Sudagar Paramjeet VPO. Loha khera Sangrur Singh Kaur 8 8 Tejinder Singh Kewal Singh Manpreet # 269, ward no-8A, Gali no-2, Sangrur Kaur Guru Teg Bahadur Nagar, Dhuri, Tehsil. Dhuri 9 9 Rajpal Singh Hardial Singh Manjeet Kaur Vill.Issi Tehsil Dhuri Sangrur 10 11 Sukhchain Roop Singh Dhan Kaur Vill. Khanal Kalan, Teshil Sangrur Singh Sunam 11 12 Sultan Bashir Shakeela Vill.Dehleez Kalan, PO. & Sangrur Mohmad Mohmad tehsil Maler Kotla 12 13 Gurdeep Bhadur Singh Paramjeet Amar colony, Malerkotla Sangrur Singh Kaur 13 14 Gagandeep Gurdev Singh Maya Kaur Vill. Alal Tehsil Dhuri Sangrur Singh 14 15 Baghel Singh Mohinder Sawarn Kaur VPO. Sherpur, Sangrur Singh 15 18 Jasveer Singh Mohinder Satya Devi Vill. Shergarh, Po. Dudian, Sangrur Singh Tehsil Moonak 16 19 Jagseer Singh Gurmail Singh Rachhpal Kaur Vill.Shergarh Singh Wala, Sangrur PO. -
List of Officers Who Attended Courses at NCRB
List of officers who attened courses at NCRB Sr.No State/Organisation Name Rank YEAR 2000 SQL & RDBMS (INGRES) From 03/04/2000 to 20/04/2000 1 Andhra Pradesh Shri P. GOPALAKRISHNAMURTHY SI 2 Andhra Pradesh Shri P. MURALI KRISHNA INSPECTOR 3 Assam Shri AMULYA KUMAR DEKA SI 4 Delhi Shri SANDEEP KUMAR ASI 5 Gujarat Shri KALPESH DHIRAJLAL BHATT PWSI 6 Gujarat Shri SHRIDHAR NATVARRAO THAKARE PWSI 7 Jammu & Kashmir Shri TAHIR AHMED SI 8 Jammu & Kashmir Shri VIJAY KUMAR SI 9 Maharashtra Shri ABHIMAN SARKAR HEAD CONSTABLE 10 Maharashtra Shri MODAK YASHWANT MOHANIRAJ INSPECTOR 11 Mizoram Shri C. LALCHHUANKIMA ASI 12 Mizoram Shri F. RAMNGHAKLIANA ASI 13 Mizoram Shri MS. LALNUNTHARI HMAR ASI 14 Mizoram Shri R. ROTLUANGA ASI 15 Punjab Shri GURDEV SINGH INSPECTOR 16 Punjab Shri SUKHCHAIN SINGH SI 17 Tamil Nadu Shri JERALD ALEXANDER SI 18 Tamil Nadu Shri S. CHARLES SI 19 Tamil Nadu Shri SMT. C. KALAVATHEY INSPECTOR 20 Uttar Pradesh Shri INDU BHUSHAN NAUTIYAL SI 21 Uttar Pradesh Shri OM PRAKASH ARYA INSPECTOR 22 West Bengal Shri PARTHA PRATIM GUHA ASI 23 West Bengal Shri PURNA CHANDRA DUTTA ASI PC OPERATION & OFFICE AUTOMATION From 01/05/2000 to 12/05/2000 1 Andhra Pradesh Shri LALSAHEB BANDANAPUDI DY.SP 2 Andhra Pradesh Shri V. RUDRA KUMAR DY.SP 3 Border Security Force Shri ASHOK ARJUN PATIL DY.COMDT. 4 Border Security Force Shri DANIEL ADHIKARI DY.COMDT. 5 Border Security Force Shri DR. VINAYA BHARATI CMO 6 CISF Shri JISHNU PRASANNA MUKHERJEE ASST.COMDT. 7 CISF Shri K.K. SHARMA ASST.COMDT. -
Kidney Disease Caused by Dysregulation of the Complement Alternative Pathway: an Etiologic Approach
BRIEF REVIEW www.jasn.org Kidney Disease Caused by Dysregulation of the Complement Alternative Pathway: An Etiologic Approach † ‡ ‡ An S. De Vriese,* Sanjeev Sethi, Jens Van Praet,* Karl A. Nath, and Fernando C. Fervenza *Division of Nephrology, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium; and Divisions of †Anatomic Pathology and ‡Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota ABSTRACT Kidney diseases caused by genetic or acquired dysregulation of the complement and atypical postinfectious GN. aHUS is a alternative pathway (AP) are traditionally classified on the basis of clinical presentation thrombotic microangiopathy (TMA) typ- (atypical hemolytic uremic syndrome as thrombotic microangiopathy), biopsy appear- ified by the triad of AKI, microangiopathic ance (dense deposit disease and C3 GN), or clinical course (atypical postinfectious GN). hemolytic anemia, and thrombocytope- Each is characterized by an inappropriate activation of the AP, eventuating in renal nia, and clinically, it is often indistinguish- damage. The clinical diversity of these disorders highlights important differences able from thrombotic thrombocytopenic in the triggers, the sites and intensity of involvement, and the outcome of the AP purpura. The C3 glomerulopathies are dysregulation. Nevertheless, we contend that these diseases should be grouped as characterized by C3 accumulation, with disorders of the AP and classified on an etiologic basis. In this review, we define absent or scanty glomerular Ig deposition different pathophysiologic categories of AP dysfunction. The precise identification of on immunofluorescence examination.3 the underlying abnormality is the key to predict the response to immune suppression, This recently coined group includes both plasma infusion, and complement-inhibitory drugs and the outcome after transplan- C3 GN and dense deposit disease (DDD), tation.