DOCSLIB.ORG

Chemical Exposure and Risk Assessment During The

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

Chemical Exposure Assessment and Control during the Manufacturing Process Practical Guidance Disclaimer Members of The intention of this document is to provide the CropLife basic guidance to the Reader on how to perform exposure and risk assessment of International EHS hazardous chemicals. Ad Hoc team on However, this document is for general information purposes only. CropLife Industrial Hygiene: International and its member companies and associations will not be held responsible Donn Cahill (Bayer) for loss which may arise from reliance on information contained in this document. Lynn Clemmons (Corteva AgriscienceTM CropLife International is not responsible Agriculture Division of DowDuPontTM) for the internet links appearing in this document, and will not be held responsible Oliver Henschel (BASF SE) for them. Kees Hommes (Bayer AG) The information contained in this document Kevin Ledgerwood is not intended as, and does not constitute, (Syngenta Crop Protection AG) legal advice to the Reader or to any person, Cecilia Stoddard (Corteva AgriscienceTM firm or entity represented by such User. Agriculture Division of DowDuPontTM) Each User must consult with his, her or its own legal counsel for independent legal André Wolters (BASF SE) advice regarding any issues associated with an exposure and risk assessment of hazardous dust. This document is not designed to define or create legal rights or obligations for CropLife International or its members. © Copyright 2019 CropLife International Contents 1. Introduction .............................................................................................................................................................................................................. 1 2. Definitions ................................................................................................................................................................................................................. 2 3. Summary ....................................................................................................................................................................................................................4 4. Responsibilities ....................................................................................................................................................................................................5 5. Process description ........................................................................................................................................................................................6 6. References ................................................................................................................................................................................................................11 Annex 1. Occupational Safety & Health Risk Assessment .....................................................................................12 Annex 2. Inventory of Hazardous Chemicals ........................................................................................................................15 Annex 3. Control Banding, tentative limit values ............................................................................................................ 16 Annex 4. Inventory of workplaces and activities ............................................................................................................. 18 Annex 5. Exposure modelling ............................................................................................................................................................... 19 Annex 6. Read-across of exposure data ..................................................................................................................................20 Annex 7. Exposure monitoring .............................................................................................................................................................21 Annex 8. Periodic monitoring .............................................................................................................................................................. 24 Annex 9. Recordkeeping of exposure monitoring data .......................................................................................... 25 Annex 10. Occupational Exposure Standards ....................................................................................................................... 26 Annex 11. Control Strategy ....................................................................................................................................................................... 29 Annex 12. Personal Protective Equipment ............................................................................................................................... 35 Annex 13. Occupational Hygiene Qualifications ................................................................................................................ 39 1. Introduction This CropLife International guidance document is intended to provide guidance to agrochemical companies and share best practices of performing an exposure and risk assessment for hazardous chemicals (including active ingredients). The goal of this guidance document is to prevent harm to employee’s health when working with chemicals. This document describes how to anticipate, recognize, evaluate and control potential chemical exposures in the workplace. The exposure assessment strategy described in this document is designed to demonstrate with a high degree of confidence that workers are unlikely to be exposed to concentrations above the exposure standard. Procedures and tools are described which, if followed, should ensure that workplace exposures are adequately controlled. Guidance is provided to assure the right combination of short and long-term controls and it enables the prioritization of control efforts and effective use of resources. It should be noted that local laws and regulations that are more stringent or conflict with this procedure take precedence. 1 2. Definitions A.I.: Active Ingredient. AIHA: American Industrial Hygiene Association. CMR: chemicals that are defined according to the Globally Harmonized System as carcinogenic, mutagenic or as toxic to reproduction. COSHH: the Control of Substances Hazardous to Health Regulations 2002, as amended is a United Kingdom Statutory Instrument that states general requirements for employers to protect workers and other persons from the hazards of substances used at work by risk assessment, control of exposure, health surveillance and incident planning. CPC: Chemical Protective Clothing. DNEL: Derived No Effect Level, is the level of exposure to a substance above which humans should not be exposed. ECETOC: European Centre for Ecotoxicology and Toxicology of Chemicals. ECHA: European Chemicals Agency. EHS: Environment, Health and Safety Exposure monitoring: to monitor (sample) workers’ exposure to chemicals or other hazardous substances. Exposure monitoring strategy: the exposure monitoring process that is designed to demonstrate with a high degree of confidence that workers are unlikely to be exposed to concentrations above the OES. Exposure Scenario: the task, or combination of multiple tasks or activities of workers that result in potential exposure to chemicals given the control measures in place. The (predicted or measured) exposure level for an exposure scenario is a combination of properties of the chemical, the frequency and duration of exposure during activities as well as the type and effectiveness of controls in place at the workplace. Hazard: a potential source of harm or adverse health effect on a person or persons ILO: International Labour Organization. IOHA: International Occupational Hygiene Association. LOQ: Limit of Quantification, the lowest concentration at which a substance analyte can not only be detected but with predefined confidence level, so that goals for bias and imprecision are met. NIOSH: National Institute of Occupational Safety and Health. NOAEL: No Observed Adverse Effect Level, the highest experimental dose level that is without adverse effect in experimental test system, e.g. animal. 2 OEB: Occupational Exposure Bands are airborne concentration ranges for products without an OES but with a similar hazard profile. These exposure bands are intended to reflect the range of full-shift exposure limit values that would be expected for a chemical with a similar hazard profile. OEL: Occupational Exposure Limit, is the maximum permissible concentration of a given gas, vapor, fiber or dust in the air in the workplace. It is intended to be the level at or below which a given substance can be present in the air in the workplace without harming the health of employees and their offspring, based on current knowledge. This should be the case even if exposure to the substance at that level occurs repeatedly or over a long period of time, even an employee’s entire working life. OES: Occupational Exposure Standard, comparable to an OEL. In this document OES is used as the generic term for atmospheric exposure limits set either by a regulatory body or by internally derived company values. OECD: Organisation for Economic Co-operation and Development. OSHRA: Occupational Safety and Health Risk Assessment. PPE: Personal Protective Equipment, is equipment which is designed to be worn or held by the worker to protect against one or more hazards (harmful effects of chemical, physical,
Recommended publications
  • Job Hazard Analysis

    Job Hazard Analysis

    Identifying and Evaluating Hazards in Research Laboratories Guidelines developed by the Hazards Identification and Evaluation Task Force of the American Chemical Society’s Committee on Chemical Safety Copyright 2013 American Chemical Society Table of Contents FOREWORD ................................................................................................................................................... 3 ACKNOWLEDGEMENTS ................................................................................................................................. 5 Task Force Members ..................................................................................................................................... 6 1. SCOPE AND APPLICATION ..................................................................................................................... 7 2. DEFINITIONS .......................................................................................................................................... 7 3. HAZARDS IDENTIFICATION AND EVALUATION ................................................................................... 10 4. ESTABLISHING ROLES AND RESPONSIBILITIES .................................................................................... 14 5. CHOOSING AND USING A TECHNIQUE FROM THIS GUIDE ................................................................. 17 6. CHANGE CONTROL .............................................................................................................................. 19 7. ASSESSING
  • Risk Assessment Guidance

    Risk Assessment Guidance

    Risk Assessment Guidance The assessor can assign values for the hazard severity (a) and likelihood of occurrence (b) (taking into account the frequency and duration of exposure) on a scale of 1 to 5, then multiply them together to give the rating band: Hazard Severity (a) Likelihood of Occurrence (b) 1 – Trivial (eg discomfort, slight bruising, self-help recovery) 1 – Remote (almost never) 2 – Minor (eg small cut, abrasion, basic first aid need) 2 – Unlikely (occurs rarely) 3 – Moderate (eg strain, sprain, incapacitation > 3 days) 3 – Possible (could occur, but uncommon) 4 – Serious (eg fracture, hospitalisation >24 hrs, incapacitation >4 4 – Likely (recurrent but not frequent) weeks) 5 – Very likely (occurs frequently) 5 – Fatal (single or multiple) The risk rating (high, medium or low) indicates the level of response required to be taken when designing the action plan. Trivial Minor Moderate Serious Fatal Rating Bands (a x b) Remote 1 2 3 4 5 LOW RISK MEDIUM RISK HIGH RISK (1 – 8) (9 - 12) (15 - 25) Unlikely 2 4 6 8 10 Continue, but Continue, but -STOP THE Possible review implement ACTIVITY- 3 6 9 12 15 periodically to additional Identify new ensure controls reasonably controls. Activity Likely remain effective practicable must not controls where 4 8 12 16 20 proceed until possible and risks are Very monitor regularly reduced to a low likely 5 10 15 20 25 or medium level 1 Risk Assessments There are a number of explanations needed in order to understand the process and the form used in this example: HAZARD: Anything that has the potential to cause harm.
  • Guidelines for Human Exposure Assessment Risk Assessment Forum

    Guidelines for Human Exposure Assessment Risk Assessment Forum

    EPA/100/B-19/001 October 2019 www.epa.gov/risk Guidelines for Human Exposure Assessment Risk Assessment Forum EPA/100/B-19/001 October 2019 Guidelines for Human Exposure Assessment Risk Assessment Forum U.S. Environmental Protection Agency DISCLAIMER This document has been reviewed in accordance with U.S. Environmental Protection Agency (EPA) policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Preferred citation: U.S. EPA (U.S. Environmental Protection Agency). (2019). Guidelines for Human Exposure Assessment. (EPA/100/B-19/001). Washington, D.C.: Risk Assessment Forum, U.S. EPA. Page | ii TABLE OF CONTENTS DISCLAIMER ..................................................................................................................................... ii LIST OF TABLES.............................................................................................................................. vii LIST OF FIGURES ........................................................................................................................... viii LIST OF BOXES ................................................................................................................................ ix ABBREVIATIONS AND ACRONYMS .............................................................................................. x PREFACE ........................................................................................................................................... xi AUTHORS, CONTRIBUTORS AND
  • Operational Risk Management Guide

    Operational Risk Management Guide

    OPERATIONAL RISK MANAGEMENT GUIDE U.S. DEPARTMENT OF AGRICULTURE FOREST SERVICE 2020 Last Updated 02/26/2020 RISK MANAGEMENT COUNCIL IN COOPERATION WITH THE OFFICE OF SAFETY & OCCUPATIONAL HEALTH and THE NATIONAL AVIATION SAFETY COUNCIL Contents Contents ....................................................................................................................................................................................... 2 Executive Summary .................................................................................................................................................................. i Introduction ............................................................................................................................................................................... 1 What is Operational Risk Management? ................................................................................................................... 1 The Terminology of ORM ................................................................................................................................................ 1 Principles of ORM Application ........................................................................................................................................... 6 The Five-Step ORM Process ................................................................................................................................................ 7 Step 1: Identify Hazards ..................................................................................................................................................
  • Cem-Seal-SDS Sheet

    Cem-Seal-SDS Sheet

    Cem-Seal ICP Building Solutions Group/Pli-Dek Version No: 1.2 Issue Date: 10/26/2020 Safety Data Sheet according to OSHA HazCom Standard (2012) requirements Print Date: 10/26/2020 S.GHS.USA.EN SECTION 1 Identification Product Identifier Product name Cem-Seal Synonyms Not Available Other means of identification Not Available Recommended use of the chemical and restrictions on use Relevant identified uses Specialty floor coating Name, address, and telephone number of the chemical manufacturer, importer, or other responsible party Registered company name ICP Building Solutions Group/Pli-Dek Address 4565 W. Watkins Street Phoenix AZ Not applicable Telephone 623-435-2277 Fax Not Available Website www.ICPGROUP.com Email Not Available Emergency phone number Association / Organisation ChemTel Emergency telephone 1-800-255-3924 numbers Other emergency telephone 1-813-248-0585 numbers SECTION 2 Hazard(s) identification Classification of the substance or mixture NFPA 704 diamond Note: The hazard category numbers found in GHS classification in section 2 of this SDSs are NOT to be used to fill in the NFPA 704 diamond. Blue = Health Red = Fire Yellow = Reactivity White = Special (Oxidizer or water reactive substances) Classification Acute Aquatic Hazard Category 3 Label elements Hazard pictogram(s) Not Applicable Signal word Not Applicable Hazard statement(s) H402 Harmful to aquatic life. Hazard(s) not otherwise classified Not Applicable Precautionary statement(s) General P101 If medical advice is needed, have product container or label at hand. P102 Keep out of reach of children. Page 1 continued... Version No: 1.2 Page 2 of 8 Issue Date: 10/26/2020 Cem-Seal Print Date: 10/26/2020 Precautionary statement(s) Prevention P273 Avoid release to the environment.
  • Biomonitoring Aquatic Ecosystem.Pdf

    Biomonitoring Aquatic Ecosystem.Pdf

    analytica chimica acta 606 (2008) 135–150 available at www.sciencedirect.com journal homepage: www.elsevier.com/locate/aca Review Biomonitoring: An appealing tool for assessment of metal pollution in the aquatic ecosystem Qunfang Zhou, Jianbin Zhang, Jianjie Fu, Jianbo Shi, Guibin Jiang ∗ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China article info abstract Article history: Wide occurrence of aquatic metal pollution has caused much attention. Biomonitoring Received 17 August 2007 offers an appealing tool for the assessment of metal pollution in aquatic ecosystem. The Received in revised form bioindicators including algae, macrophyte, zooplankton, insect, bivalve mollusks, gastro- 7 November 2007 pod, fish, amphibian and others are enumerated and compared for their advantages and Accepted 7 November 2007 disadvantages in practical biomonitoring of aquatic metal pollution. The common biomon- Published on line 19 November 2007 itoring techniques classified as bioaccumulation, biochemical alterations, morphological and behavior observation, population- and community-level approaches and modeling are Keywords: discussed. The potential applications of biomonitoring are proposed to mainly include Biomonitoring evaluation of actual aquatic metal pollution, bioremediation, toxicology prediction and Metal pollution researches on toxicological mechanism. Further perspectives are made for the biomoni- Aquatic ecosystem toring of metal
  • Biomonitoring a Best Practices Report for State Legislators

    Biomonitoring a Best Practices Report for State Legislators

    Biomonitoring A Best Practices Report for State Legislators BIOMONITORING A BEST PR A CTICES RE P ORT FOR ST A TE LEGIS la TORS By Scott Hendrick Doug Farquhar William T. Pound, Executive Director 7700 East First Place Denver, CO 80230 (303) 364-7700 444 North Capitol Street, N.W., Suite 515 Washington, D.C. 20001 (202) 624-5400 www.ncsl.org May 2010 The National Conference of State Legislatures is the bipartisan organization that serves the legislators and staffs of the states, commonwealths and territories. NCSL provides research, technical assistance and opportunities for policymakers to exchange ideas on the most pressing state issues and is an effective and respected advocate for the inter- ests of the states in the American federal system. Its objectives are: • To improve the quality and effectiveness of state legislatures. • To promote policy innovation and communication among state legislatures. • To ensure state legislatures a strong, cohesive voice in the federal system. The Conference operates from offices in Denver, Colorado, and Washington, D.C. This publication was developed with support from the Centers for Disease Control and Pre- vention and the Association of Public Health Laboratories. NCSL graciously acknowledges their support. This publication was supported by the Association of Public Health Laboratories and Cooperative Agreement Number #U60/CD303019 from Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of CDC. Printed on recycled paper © 2010 by the National Conference of State Legislatures. All rights reserved. ISBN 1-978-58124-596-8 Biomonitoring iii CONTENTS About the Authors....................................................................................................................................
  • Control Banding in the Pharmaceutical Industry

    Control Banding in the Pharmaceutical Industry

    CONTROL BANDING IN THE PHARMACEUTICAL INDUSTRY BRUCE D. NAUMANN, Ph.D., DABT Merck & Co., Inc. Summary The pharmaceutical industry embraced the concept of control banding many years ago. Control banding is a process of assigning a compound to a hazard category that corresponds to a range of airborne concentrations – and the engineering controls, administrative controls, and personal protective equipment – needed to ensure safe handling. While the terminology used was different, the high potency of some pharmaceutical compounds required the use of alternatives to setting numerical occupational exposure limits (OELs), e.g., performance-based exposure control limits (PB-ECLs) or occupational exposure bands (OEBs), especially for early development compounds with limited information. The long experience in setting OELs for active pharmaceutical ingredients, and the myriad of engineering solutions required to achieve these internal exposure standards, paved the way for a more performance-based approach. Enrolment criteria were developed that were more descriptive than the prescriptive risk phrases used in the UK’s COSHH Essentials. The latter do not adequately address the types of effects potentially produced by pharmaceuticals, especially highly potent compounds. Internal experts are available in pharmaceutical companies to interpret the preclinical and clinical data for new drug products, including those with novel therapeutic mechanisms, against technical enrolment criteria that require more professional judgment. The range of concentrations covered by control bands used in the industry is fairly consistent and generally reflects full log intervals. The boundaries differ slightly in some cases because verification studies have identified different break points for various new control technologies employed. There are also “semantic” differences in how control bands are named – most use numbers but these may point to different ranges.
  • Safety Manual

    Safety Manual

    Eastern Elevator Safety and Health Manual January 2017 Page 1 of 125 SAFETY AND HEALTH MANUAL Index by Section Number Safety Policy ................................................................................................................. …4 Section 1: General Health and Safety Policies ............................................................. …5 Section 2: Hazard Communication ................................................................................ ..13 Section 3: Personal Protective Equipment (PPE) ......................................................... ..18 Section 4: Emergency Action Plan ................................................................................ ..31 Section 5: Fall Protection .............................................................................................. ..34 Section 6: Ladder Safety ............................................................................................... ..38 Section 7: Bloodborne Pathogens ................................................................................ ..42 Section 8: Motor Vehicle / Fleet Safety ......................................................................... ..47 Section 9: Hearing Conservation .................................................................................. ..50 Section 10: Lockout / Tagout ........................................................................................ ..53 Section 11: Fire Prevention ..........................................................................................
  • A PRACTICAL GUIDE for USE of REAL TIME DETECTION SYSTEMS for WORKER PROTECTION and COMPLIANCE with OCCUPATIONAL EXPOSURE LIMITS May 2019

    A PRACTICAL GUIDE for USE of REAL TIME DETECTION SYSTEMS for WORKER PROTECTION and COMPLIANCE with OCCUPATIONAL EXPOSURE LIMITS May 2019

    A PRACTICAL GUIDE FOR USE OF REAL TIME DETECTION SYSTEMS FOR WORKER PROTECTION AND COMPLIANCE WITH OCCUPATIONAL EXPOSURE LIMITS May 2019 WHITE PAPER May 2019 A PRACTICAL GUIDE FOR USE OF REAL TIME DETECTION SYSTEMS FOR WORKER PROTECTION AND COMPLIANCE WITH OCCUPATIONAL EXPOSURE LIMITS Prepared by: Energy Facility Contractor’s Group (EFCOG) Industrial Hygiene and Safety Task Group and Members of the American Industrial Hygiene Association (AIHA) Exposure Assessment Strategies Group Dina Siegel1, David Abrams 2, John Hill3, Steven Jahn2, Phil Smith2, Kayla Thomas4 1 Los Alamos National Laboratory 2 AIHA Exposure Assessment Strategies Committee 3 Savannah River Site 4 Kansas City National Security Campus A PRACTICAL GUIDE FOR USE OF REAL TIME DETECTION SYSTEMS FOR WORKER PROTECTION AND COMPLIANCE WITH OCCUPATIONAL EXPOSURE LIMITS May 2019 Table of Contents 1.0 Executive Summary 2.0 Introduction 3.0 Discussion 3.1 Occupational Exposure Assessment 3.2 Regulatory Compliance 3.3 Occupational Exposure Limits 3.4 Traditional Use of Real Time Detection Systems 3.5 Use and Limitations of Real Time Detection Systems 3.6 Use of Real Time Detection Systems for Compliance 3.7 Documentation/Reporting of Real Time Detection Systems Results 3.8 Peak Exposures Data Interpretations 3.9 Conclusions 4.0 Matrices 5.0 References 6.0 Attachments Page | 2 A PRACTICAL GUIDE FOR USE OF REAL TIME DETECTION SYSTEMS FOR WORKER PROTECTION AND COMPLIANCE WITH OCCUPATIONAL EXPOSURE LIMITS May 2019 1.0 Executive Summary This white paper presents practical guidance for field industrial hygiene personnel in the use and application of real time detection systems (RTDS) for exposure monitoring.
  • Biomonitoring of Lead and Cadmium Preliminary Study on the Added Value for Human Exposure and Effect Assessment

    Biomonitoring of Lead and Cadmium Preliminary Study on the Added Value for Human Exposure and Effect Assessment

    Biomonitoring of lead and cadmium Preliminary study on the added value for human exposure and effect assessment RIVM Letter report 2016-0215 B. Tiesjema │ M. Mengelers Biomonitoring of lead and cadmium Preliminary study on the added value for human exposure and effect assessment RIVM Letter report 2016-0215 B. Tiesjema│M. Mengelers RIVM Letter report 2016-0215 Colophon © RIVM 2017 Parts of this publication may be reproduced, provided acknowledgement is given to: National Institute for Public Health and the Environment, along with the title and year of publication. B. Tiesjema (author), RIVM M. Mengelers (author), RIVM Contact: [email protected] This investigation has been performed by order and for the account of the Netherlands Food and Consumer Product Safety Authority (NVWA), Office for Risk Assessment and Research, within the framework of the project ‘Indicators for human body burden’, research question 9.1.62. This is a publication of: National Institute for Public Health and the Environment P.O. Box 1 | 3720 BA Bilthoven The Netherlands www.rivm.nl/en Page 2 of 49 RIVM Letter report 2016-0215 Synopsis Biomonitoring of lead and cadmium Preliminary study on the added value for human exposure and effect assessment People are exposed to all kinds of substances (for example via food) , which can be harmful to their health. To accurately estimate the health effects, it is important to determine to what extent these substances actually harm the body. In order to do so it may be helpful to measure concentrations of these substances in body fluids and/or tissues (biomonitoring). RIVM chose the substances lead and cadmium to investigate to what extent such measurements show a relationship with the exposure as well as the health effects of these substances.
  • Controlling Chemical Exposure Industrial Hygiene Fact Sheets

    Controlling Chemical Exposure Industrial Hygiene Fact Sheets

    Controlling Chemical Exposure Industrial Hygiene Fact Sheets Concise guidance on 16 components of industrial hygiene controls New Jersey Department of Health and Senior Services Division of Epidemiology, Environmental and Occupational Health Occupational Health Service PO Box 360 Trenton, NJ 08625-0360 609-984-1863 October 2000 James E. McGreevey Clifton R. Lacy, M.D. Governor Commissioner Written by: Eileen Senn, MS, CIH Occupational Health Surveillance Program James S. Blumenstock Senior Assistant Commissioner Public Health Protection and Prevention Programs Eddy Bresnitz, MD, MS State Epidemiologist/Assistant Commissioner Division of Epidemiology, Environmental and Occupational Health Kathleen O’Leary, MS Director Occupational Health Service David Valiante, MS, CIH Acting Program Manager Occupational Health Surveillance Program Funding: This project was supported in part by a cooperative agreement from the U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health (NIOSH). Reproduction: The NJDHSS encourages the copying and distribution of all or parts of this booklet. All materials are in the public domain and may be reproduced or copied without permission. Cita- tion as to the source is appreciated. This document is available on the Internet at: www.state.nj.us/health/eoh/survweb/ihfs.pdf Citation: Senn, E., Controlling Chemical Exposure; Industrial Hygiene Fact Sheets, Trenton, NJ: New Jersey Department of Health and Senior Services, October 2000. Table of Contents Methods for Controlling