AUTOIMMUNE DISEASES Diagnosis and Interpretation
Organized By Date March 23, 2014 Venue Microbiological Laboratory IMA Hall, (NABL Accredited), Coimbatore Syrian Church Road, & Coimbatore Indian Association of Medical Microbiologists Time Tamil Nadu Pondicherry Chapter 9am - 6pm Mariappa Mani Chairman-CME, Managing Director-Microbiological Laboratory ...... In an autoimmune reaction, the immune system attacks thyself by mistake and harms the body's own tissues. The autoimmune diseases comprise a group of immunologic disorders whose common denominator is the presence of an idiopathic systemic autoimmune process. The MICROBIOLOGICAL LABORATORY, Coimbatore provides a comprehensive panel of diagnostic services using the latest scientific discoveries to provide innovative methods in the detection, diagnosis and treatment assessment of immunologic, hematologic, pathologic, biochemical and oncologic disease states. A quiet revolution in the field of autoimmunity is underway. Its objective is to provide simple and accurate results for making laboratory diagnosis of autoimmune diseases. Although the autoimmune diseases share many common features and clinical presentations, differentiation between the diseases is crucial because of important distinction in clinical course, appropriate treatment and prognosis. Hence, there is urgent need to review and update the current scenario on clinical manifestation, laboratory diagnosis and practical interpretations of autoimmune diseases.
We, at the Microbiological Laboratory are always on the search for new paths in science and newer technologies in life saving diagnostics. Therefore, in order to answer to dilemmas and interpretations in the diagnosis of autoimmune serology we proudly present our second CME on AUTOIMMUNE DISEASES: DIAGNOSIS AND INTERPRETATIONS on 23rd March, 2014. The purpose of the CME is to provide an intellectual forum for all clinicians and researchers from around the nation to discuss on diagnosis, pathogenesis, and interpretation of practical issues in autoimmune diseases.
With Regards,
Mariappa Mani Chairman-CME, Managing Director-Microbiological Laboratory
23, March Course Description
Invited speakers are chosen based on their expertise in basic and clinical immunology, as well as their teaching skills. The lectures cover the major topics in autoimmune, allergic and immunodeficiency diseases, as well as new advances in interventional and clinical immunology. All lecturers encourage interaction with the participants through questions and discussions during lecture time. There is also an opportunity for students to interact with the faculty outside the lecture room. Target Audience
This CME is designed for all medical practitioners, medical academicians, practicing rheumatologists and transplantation specialist. The target audience includes all medical practitioners, clinical fellows in disciplines related to immunology, including rheumatology, allergy, infectious disease, oncology and transplantation; fellows doing basic research with an emphasis on human disease; scientists or other research and development personnel from biotechnology and pharmaceutical companies who are involved in developing new therapies for immunological disease; and academic or community physicians who wish to enhance their understanding of immunology. Course Objectives
At the conclusion of this course, attendees will be able to:
·Understand the fundamental mechanisms underlying autoimmune diseases.
·Update the recent advances in the diagnosis of autoimmune diseases.
·Discuss the interpretations and practical challenges in diagnostic interventions. Attendance & Accreditation This CME activity has been planned and implemented in accordance with The Tamil Nadu Medical Council, Chennai and is accredited for Continuing Medical Education to provide continuing medical education credits (2 credit hours of Category 1) for medical practitioners and medical faculties along with attendance certificate.
23, March Organizing Committee
President-CME General Secretary-CME Chairman-CME
Dr. KM. Mythreyee, Dr. N. Palaniappan, Director, Mr M. Mani, Managing Director, President-IAMM-TN-PY Chapter, Institute of Microbiology Microbiological Laboratory, Vice Principal, Theni Govt. Govt Madurai Medical College, Coimbatore Medical College, Theni. Madurai
Vice Chairman-CME Program Director-CME Program Director-CME Dr Krishna Venkateshwaran, Dr K.M Brahmadathan, Dr C.P Thangavelu, HOD of Pathology, Dept. of Microbiology, Dept. of Microbiology, Microbiological Laboratory, Microbiological Laboratory, Microbiological Laboratory, Coimbatore Coimbatore Coimbatore
Treasurer-CME Organizing Secretary Travel Coordinator
Mr R. Meenakshi Sundram Dr M Jayahar Bharathi Mr John X Jeyaseelan 03 23, March Member Core-Committee
Dr. V S Nagabhushan., Ph.D., Dr. R Boopathy., Ph.D., Dr. N Dheepa, MD., Microbiological Laboratory Microbiological Laboratory Microbiological Laboratory
Dr T. Amala Rajasundari Ph.D., Mrs U. Devaki, Msc., Mrs R. Dhanalakshmi, Msc., Microbiological Laboratory Microbiological Laboratory Microbiological Laboratory
Mrs M. Sirajunnisha Msc., Mrs T. Helen Hencida, Msc., Mrs R. Baghiam, Microbiological Laboratory Microbiological Laboratory Microbiological Laboratory 03 23, March Speaker’s Profile
Dr CN Srinivasan Director, Clinical Laboratory Service, MIOT International Hospital, Chennai
Dr. Chakravarthy Narasimhachar Srinivas, MD (Pathology)., DNB., (Pathology), Graduate -Certificate in
Clinical lab Management and Leadership (AACC), Fellow, College of American Pathologists (FCAP), Global
Outreach Consultant-ASCP ISO:15189:2007-Assessor, NABH-QCI Med lab Lead Assessor and CAP-LAP
Inspector, Currently Director- Clinical lab Services, Transplantation Immunology and Molecular laboratory
at MIOT Hospitals, Chennai and consultant pathologist, YRG CARE,Chennai.
Speaker’s Abstract Laboratory Approaches to Autoimmune Diseases
Detection and quantitation of auto antibodies are vital tests in the diagnosis and management of patients with autoimmune diseases (AIDs). Manual, qualitative or semi-quantitative assays were in by quantitative automated high-volume solid phase methods. The assays now available have improved our diagnostic power and consequently increased the impact of AIDs in daily practice, both from a clinical and a laboratory point of view. The current tests are mainly based on ELISA or other new solid phase methods, including the micro array systems. These assays are now widely available on automated analyzers and are being moved from dedicated specialized laboratories into high throughput routine service laboratories.
23, March Speaker’s Profile
Dr Sudheeran Kannoth MD., DM., Dept. of Neurology, Clinical Asst. Professor, Amrita Institute of Medical Sciences
Dr. Sudheeran Kannoth, MD., General Medicine, JIPMER, DM., Neurology- SCTIMST, Trivandrum, Fellowship in autoimmune neurology Mayo Clinic, Presently working as Assistant Professor of Neurology-Amrita Institute of Medical Sciences, Kochi
Autoimmune Neurological Disorders Speaker’s Abstract & Laboratory Diagnosis
Autoimmune neurological disorders involve the widest spectrum of neurological disorders. It includes diseases involving all other subspecialities of neurology- cognition, epilepsy, encephalitis, ataxia, myelopathy etc. Neuroimmunolgy lab work up is an important arm in the diagnosis of these disorders. This includes testing for neuronal antibodies, VGKC antibody, NMDA receptor antibody.
23, March Speaker’s Profile
Dr Krishna Venkateshwaran Head, Dept. of Pathology, Microbiological Laboratory, Coimbatore
Dr Krishna Venkateswaran graduated in Medicine from the University of Mysore (1982). He was a gold medalist & University topper in many subjects. He went on to obtain his MD (Pathology) from Post- Graduation Institution of Medical Education & Research, Chandigarh. He pursed his studies in the same institution to acquire Diploma of National Board Examination (1989). He started his own pathology lab in Chennai that was subsequently taken over by Micro Lab at Coimbatore in 2005. A Voracious reader himself, he has authored a Textbook of Pathology (2004); Orient Longman (now Orient Blacksman). He also published many papers in the field of Pathology.
Speaker’s Abstract Interpretation of Laboratory tests in Autoimmune Diseases: Practical Issues
Taking ANA as the example, this 30 minute summation will address practical issues in the final interpretation and further action to be taken by the Physician, the Patient and the Laboratory. These include, choice of initial tests, choice of test format, the need for clinical information inputs, the need for an algorithmic approach and the often neglected aspect of the Physician—Laboratory dialogue that ends up helping all.
23, March Speaker’s Profile
Dr K.N Brahmadathan Head, Dept. of Microbiology, Microbiological Laboratory, Coimbatore
Dr K.N Brahmadathan completed his M.sc & Ph.D in Medical Microbiology at CMC, Vellore. He became the faculty member of the department, went on to become the professor till his retirement in 2008. Over a period of 28 years, he has done pioneering work on Streptococcus Pyogenes. He has more than 70 publications in national & international journals & has presented papers in National & International Conferences. He has guided several students for their M.sc, MD & Ph.D degrees. He has awarded several research grants from ICMR, DST, DBT, NIH(USA) & European Union. He was the Deputy-Chairman of the Hospital Infection Control Committee at CMC for several years. Dr Dathan joined Microbiological Laboratory in 2008 as the Director of Research & is involved in exploring the etiology of viral infections, such as H1N1, HIV, HBV, HCV, HPV & etc., at molecular levels.
The Role of Infections in the Speaker’s Abstract Pathogenesis of Autoimmune Diseases
An association between microbial infections and development of autoimmune diseases (AD) has long been debated. Various theories including hidden antigen, epitope spread, anti-idiotypes, molecular mimicry, the adjuvant effect and antigenic complementarity have been put forward. It could also be due to an activation of subversion of immune response by microbes. Recent evidence suggest that specific activation of innate immune responses are critical while immunological cross-reactivity may exaggerate immune responses leading to chronic autoinflammatory diseases.
23, March Speaker’s Profile
Dr John Antony Jude Prakash Professor, Dept. of Clinical Microbiology, Christian Medical College, Vellore
Dr. John Antony Jude Prakash, MD., (Microbiology), Professor, Immunology Laboratories, Dept of Clinical Microbiology, Christian Medical College, Vellore-632004. He was a visiting scientist on 13th September 2011 and 26th September, 2012 at the Department of Preventive Medicine & Biometrics, Uniformed Services University of Health Sciences, Bethesda, MD, USA and Naval Medical Research Centre, Silver Spring, MD, USA. He is a reviewer for American Journal of Tropical Medicine and Hygiene, and Journal of Diagnostic Microbiology and Infectious Diseases. Currently he is in-charge of exudates section, anaerobes, the immunology labs and media section, and Quality Manager of Department of Clinical Microbiology, Christian Medical College, Vellore. Autoimmune Hepatitis: Speaker’s Abstract Laboratory Aspects
Auto-immune hepatitis (AIH) is defined as a progressive inflammation of the liver of unknown cause which affects women mostly and responds to immunosuppressive therapy. AIH has a wide spectrum of clinical manifestations ranging from asymptomatic to severe disease. It is classified into two types, type 1 AIH and type 2 AIH. Anti-Nuclear Antibodies (ANA) and Anti-Smooth Muscle Antibodies (ASMA) / Anti- Actin Antibodies (AAA) are seen in type 1 AIH. In type 2 AIH antibodies to Liver / Kidney Microsomes (LKM1) or Liver Cytosolic Antigen (LC-1) are seen. Antibodies to Soluble Liver Antigens (SLA) can be seen in both type1 & type 2 AIH and suggests severe disease. Anti-bodies to ANA, ASMA, LKM1 are detected by IFA, whereas those for SLA are better detected by ELISA. The talk will deal with the diagnostic and prognostic relevance auto-antibodies in AIH based on our experience. 23, March Notes
23, March Name of faculty Topics Name of the Chair-person
Dr. CN Srinivasan, Laboratory Dr. Krishna Venkateshwaran Director, Clinical Laboratory Services, Approaches to Head, Dept. of Pathology, MIOT International Hospital,Chennai Autoimmune Diseases Microbiological Laboratory, Coimbatore
Dr KM Mythreyee Dr John Antony Jude Autoimmune Hepatitis: President -IAMM-TM-PY Chapter Prakash, Professor, Laboratory Aspects Vice Principal, Theni Govt. Dept.of Clinical Microbiology, Medical College, Theni Christian Medical College, Vellore
Dr.N.Palaniappan Autoimmune Dr. Sudheeran Kannoth MD., DM., Director, Institute of Neurological Disorder Dept of Neurology, Clinical Asst. Prof, Microbiology, Govt.Madurai & Laboratory Diagnosis Amrita Institute of Medical Sciences Medical College, Madurai
Dr. Krishna Venkateshwaran, Interpretation of Dr. CN Srinivasan Head, Dept. of Pathology, Laboratory tests in Director, Clinical Laboratory Services, Microbiological Laboratory, Coimbatore Autoimmune Diseases: MIOT International Hospital,Chennai Practical Issues.
Dr. Brahmadathan, The Role of Infections Dr. CP Thangavelu Head, Dept. of Microbiology, in the Pathogenesis of Dept of Microbiology, Microbiological Laboratory, Coimbatore Autoimmune Diseases Microbiological Laboratory, Coimbatore
23, March