Detecting Floating-Point Errors Via Atomic Conditions
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Unnatural Amino Acid Incorporation to Rewrite The
Unnatural Amino Acid Incorporation to Rewrite the Genetic Code and RNA-peptide Interactions Thesis by Xin Qi In partial fulfillment of the requirements for the degree of Doctor of Philosophy California Institute of Technology Pasadena, California 2005 (Defended May 19, 2005) ii © 2005 Xin Qi All Rights Reserved iii Acknowledgments I like to sincerely thank my advisor, Dr. Richard W. Roberts, for his great mentorship over the course of my graduate career here at Caltech. This thesis would have not been possible without his tremendous scientific vision and a great deal of guidance. I am also in debt to Dr. Peter Dervan, Dr. Robert Grubbs, and Dr. Stephen Mayo, who serve on my thesis committee. They have provided very valuable help along the way that kept me on track in the pursuit of my degree. I have been so fortunate to have been working with a number of fantastic colleagues in Roberts’ group. Particularly, I want express my gratitude toward Shelley R. Starck, with whom I had a productive collaboration on one of my projects. Members of Roberts group, including Shuwei Li, Terry Takahashi, Ryan J. Austin, Bill Ja, Steve Millward, Christine Ueda, Adam Frankel, and Anders Olson, all have given me a great deal of help on a number of occasions in my research, and they are truly fun people to work with. I also like to thank our secretary, Margot Hoyt, for her support during my time at Caltech. I have also collaborated with people from other laboratories, e.g., Dr. Cory Hu from Prof. Varshavsky’s group, and it has been a positive experience to have a nature paper together. -
Archaeological Observation on the Exploration of Chu Capitals
Archaeological Observation on the Exploration of Chu Capitals Wang Hongxing Key words: Chu Capitals Danyang Ying Chenying Shouying According to accurate historical documents, the capi- In view of the recent research on the civilization pro- tals of Chu State include Danyang 丹阳 of the early stage, cess of the middle reach of Yangtze River, we may infer Ying 郢 of the middle stage and Chenying 陈郢 and that Danyang ought to be a central settlement among a Shouying 寿郢 of the late stage. Archaeologically group of settlements not far away from Jingshan 荆山 speaking, Chenying and Shouying are traceable while with rice as the main crop. No matter whether there are the locations of Danyang and Yingdu 郢都 are still any remains of fosses around the central settlement, its oblivious and scholars differ on this issue. Since Chu area must be larger than ordinary sites and be of higher capitals are the political, economical and cultural cen- scale and have public amenities such as large buildings ters of Chu State, the research on Chu capitals directly or altars. The site ought to have definite functional sec- affects further study of Chu culture. tions and the cemetery ought to be divided into that of Based on previous research, I intend to summarize the aristocracy and the plebeians. The relevant docu- the exploration of Danyang, Yingdu and Shouying in ments and the unearthed inscriptions on tortoise shells recent years, review the insufficiency of the former re- from Zhouyuan 周原 saying “the viscount of Chu search and current methods and advance some personal (actually the ruler of Chu) came to inform” indicate that opinion on the locations of Chu capitals and later explo- Zhou had frequent contact and exchange with Chu. -
Southeast Asia
SOUTHEAST ASIA Shang Dynasty Zhou Dynasty ● Time of emergence: 1766 BC ● Time of emergence: 1046-256 BCE ● Time they were at their peak:1350 BC ● Divided into 2 different periods (Western Zhou: ● Time they were around: 1766-1122 BC 1046-771 BCE)(Eastern Zhou: 770-256 BCE) ● Time of fall: 1122 BC ● They were around for 8 centuries (800+ years) ● Time of fall: 256 BCE GEOGRAPHIC IMPACT ON SOCIETY Shang Dynasty Zhou Dynasty The Shang Dynasty controlled the North China Plain, which ● They were located west of Shang Dynasty however after corresponds to the modern day Chinese provinces of Anhui, Hebei, conquering Shang Dynasty, their borders extended as far Henan, Shandong, and Shanxi. The area that those of the Shang south as chang Jiang river and east to the Yellow sea. Dynasty lived in, under the Yellow River Valley, gave them water as These body of waters provided fertile soil for good farming well as fertile soil which helped their civilization thrive. Natural borders, and their trading increased. ● Present day location: Xi’an in Shaanxi near the Wei river such as mountains, also protected the area, making it easier to protect. and confluence of the Yellow river The Yellow River also made it easy for the people that lived there to ● They were not geographically isolated from other obtain a steady supply of water. civilizations ● They were exposed to large bodies of water POLITICAL SYSTEM AND IMPACT ON SOCIETY government Shang Dynasty Zhou Dynasty The Shang Dynasty was ruled by a ● The Zhou Dynasty ruled with a confucian social hierarchy hereditary monarchy, in which the ● The citizens were expected to follow the rules and values of confucianism government wa controlled by the king Organization: mainly, and the line of rule descended ● Had the “mandate of heaven” through the family. -
The History of Holt Cheng Starts 88Th
The Very Beginning (written with great honor by cousin Basilio Chen 鄭/郑华树) The Roots Chang Kee traces his family roots as the 87th descendant of Duke Huan of Zheng (鄭桓公), thus posthumorously, Dr. Holt Cheng is referred to in the ancient family genealogical tradition Duke Holt Cheng, descendant of the royal family Zhou (周) from the Western Zhou Dynasty. The roots and family history of Chang Kee starts over 2,800 years ago in the Zhou Dynasty (周朝) when King Xuan (周宣王, 841 BC - 781 BC), the eleventh King of the Zhou Dynasty, made his younger brother Ji You (姬友, 806 BC-771 BC) the Duke of Zheng, establishing what would be the last bastion of Western Zhou (西周朝) and at the same time establishing the first person to adopt the surname Zheng (also Romanized as Cheng in Wades-Giles Dictionary of Pronunciation). The surname Zheng (鄭) which means "serious" or " solemn", is also unique in that is the only few surname that also has a City-State name associated it, Zhengzhou city (鄭國 or鄭州in modern times). Thus, the State of Zheng (鄭國) was officially established by the first Zheng (鄭,) Duke Huan of Zheng (鄭桓公), in 806 BC as a city-state in the middle of ancient China, modern Henan Province. Its ruling house had the surname Ji (姬), making them a branch of the Zhou royal house, and were given the rank of bo (伯,爵), corresponding roughly to an earl. Later, this branch adopted officially the surname Zheng (鄭) and thus Ji You (or Earl Ji You, as it would refer to in royal title) was known posthumously as Duke Huan of Zheng (鄭桓公) becoming the first person to adopt the family surname of Zheng (鄭), Chang Kee’s family name in Chinese. -
Table of Contents (PDF)
Cancer Prevention Research Table of Contents June 2017 * Volume 10 * Number 6 RESEARCH ARTICLES 355 Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for 319 Statin Use, Serum Lipids, and Prostate Oral Cancer Occurrence Inflammation in Men with a Negative Prostate Chia-Min Chung, Chien-Hung Lee, Mu-Kuan Chen, Biopsy: Results from the REDUCE Trial Ka-Wo Lee, Cheng-Che E. Lan, Aij-Lie Kwan, Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Ming-Hsui Tsai, and Ying-Chin Ko Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland 363 A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early 327 Sleep Duration across the Adult Lifecourse and Breast Cancer Risk of Lung Cancer Mortality: A Cohort Study in Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Xuanwei, China Sara Gandini, Harriet Johansson, Davide Serrano, Jason Y. Wong, Bryan A. Bassig, Roel Vermeulen, Wei Hu, Massimiliano Cazzaniga, Valentina Aristarco, Bofu Ning, Wei Jie Seow, Bu-Tian Ji, Debora Macis, Serena Mora, Pietro Caldarella, George S. Downward, Hormuzd A. Katki, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Francesco Barone-Adesi, Nathaniel Rothman, Giovanna Petrangolini, Paolo Morazzoni, Robert S. Chapman, and Qing Lan Andrea DeCensi, and Bernardo Bonanni 337 Bitter Melon Enhances Natural Killer–Mediated Toxicity against Head and Neck Cancer Cells Sourav Bhattacharya, Naoshad Muhammad, CORRECTION Robert Steele, Jacki Kornbluth, and Ratna B. Ray 371 Correction: New Perspectives of Curcumin 345 Bioactivity of Oral Linaclotide in Human in Cancer Prevention Colorectum for Cancer Chemoprevention David S. Weinberg, Jieru E. Lin, Nathan R. -
Suppression of DNA-Damage Checkpoint Signaling by Rsk-Mediated Phosphorylation of Mre11
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11 Chen Chen, Liguo Zhang, Nai-Jia Huang, Bofu Huang, and Sally Kornbluth1 Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 Edited by Tony Hunter, The Salk Institute for Biological Studies, La Jolla, CA, and approved November 12, 2013 (received for review April 9, 2013) Ataxia telangiectasia mutant (ATM) is an S/T-Q–directed kinase A hallmark of cancer cells is their ability to override cell-cycle that is critical for the cellular response to double-stranded breaks checkpoints, including the DSB checkpoint, which arrests the cell (DSBs) in DNA. Following DNA damage, ATM is activated and cycle to allow adequate time for damage repair. Previous studies recruited by the MRN protein complex [meiotic recombination 11 have implicated the MAPK pathway in inhibition of DNA-dam- (Mre11)/DNA repair protein Rad50/Nijmegen breakage syndrome age signaling: PKC suppresses DSB-induced G2/M checkpoint 1 proteins] to sites of DNA damage where ATM phosphorylates signaling following ionizing radiation via activation of ERK1/2 multiple substrates to trigger cell-cycle arrest. In cancer cells, this (22); activation of RAF kinase, leading to activation of MEK/ regulation may be faulty, and cell division may proceed even in ERK/Rsk, also can suppress G2/M checkpoint signaling (23). the presence of damaged DNA. We show here that the ribosomal Given its prominent role in multiple cancers, the MAPK s6 kinase (Rsk), often elevated in cancers, can suppress DSB-induced pathway is an attractive therapeutic target. Indeed, treatment of melanoma using the RAF inhibitor vemurafenib has shown some ATM activation in both Xenopus egg extracts and human tumor cell clinical success, as has treatment of nonsmall cell lung carcinoma lines. -
Originally, the Descendants of Hua Xia Were Not the Descendants of Yan Huang
E-Leader Brno 2019 Originally, the Descendants of Hua Xia were not the Descendants of Yan Huang Soleilmavis Liu, Activist Peacepink, Yantai, Shandong, China Many Chinese people claimed that they are descendants of Yan Huang, while claiming that they are descendants of Hua Xia. (Yan refers to Yan Di, Huang refers to Huang Di and Xia refers to the Xia Dynasty). Are these true or false? We will find out from Shanhaijing ’s records and modern archaeological discoveries. Abstract Shanhaijing (Classic of Mountains and Seas ) records many ancient groups of people in Neolithic China. The five biggest were: Yan Di, Huang Di, Zhuan Xu, Di Jun and Shao Hao. These were not only the names of groups, but also the names of individuals, who were regarded by many groups as common male ancestors. These groups first lived in the Pamirs Plateau, soon gathered in the north of the Tibetan Plateau and west of the Qinghai Lake and learned from each other advanced sciences and technologies, later spread out to other places of China and built their unique ancient cultures during the Neolithic Age. The Yan Di’s offspring spread out to the west of the Taklamakan Desert;The Huang Di’s offspring spread out to the north of the Chishui River, Tianshan Mountains and further northern and northeastern areas;The Di Jun’s and Shao Hao’s offspring spread out to the middle and lower reaches of the Yellow River, where the Di Jun’s offspring lived in the west of the Shao Hao’s territories, which were near the sea or in the Shandong Peninsula.Modern archaeological discoveries have revealed the authenticity of Shanhaijing ’s records. -
The Analects of Confucius
The analecTs of confucius An Online Teaching Translation 2015 (Version 2.21) R. Eno © 2003, 2012, 2015 Robert Eno This online translation is made freely available for use in not for profit educational settings and for personal use. For other purposes, apart from fair use, copyright is not waived. Open access to this translation is provided, without charge, at http://hdl.handle.net/2022/23420 Also available as open access translations of the Four Books Mencius: An Online Teaching Translation http://hdl.handle.net/2022/23421 Mencius: Translation, Notes, and Commentary http://hdl.handle.net/2022/23423 The Great Learning and The Doctrine of the Mean: An Online Teaching Translation http://hdl.handle.net/2022/23422 The Great Learning and The Doctrine of the Mean: Translation, Notes, and Commentary http://hdl.handle.net/2022/23424 CONTENTS INTRODUCTION i MAPS x BOOK I 1 BOOK II 5 BOOK III 9 BOOK IV 14 BOOK V 18 BOOK VI 24 BOOK VII 30 BOOK VIII 36 BOOK IX 40 BOOK X 46 BOOK XI 52 BOOK XII 59 BOOK XIII 66 BOOK XIV 73 BOOK XV 82 BOOK XVI 89 BOOK XVII 94 BOOK XVIII 100 BOOK XIX 104 BOOK XX 109 Appendix 1: Major Disciples 112 Appendix 2: Glossary 116 Appendix 3: Analysis of Book VIII 122 Appendix 4: Manuscript Evidence 131 About the title page The title page illustration reproduces a leaf from a medieval hand copy of the Analects, dated 890 CE, recovered from an archaeological dig at Dunhuang, in the Western desert regions of China. The manuscript has been determined to be a school boy’s hand copy, complete with errors, and it reproduces not only the text (which appears in large characters), but also an early commentary (small, double-column characters). -
Official Colours of Chinese Regimes: a Panchronic Philological Study with Historical Accounts of China
TRAMES, 2012, 16(66/61), 3, 237–285 OFFICIAL COLOURS OF CHINESE REGIMES: A PANCHRONIC PHILOLOGICAL STUDY WITH HISTORICAL ACCOUNTS OF CHINA Jingyi Gao Institute of the Estonian Language, University of Tartu, and Tallinn University Abstract. The paper reports a panchronic philological study on the official colours of Chinese regimes. The historical accounts of the Chinese regimes are introduced. The official colours are summarised with philological references of archaic texts. Remarkably, it has been suggested that the official colours of the most ancient regimes should be the three primitive colours: (1) white-yellow, (2) black-grue yellow, and (3) red-yellow, instead of the simple colours. There were inconsistent historical records on the official colours of the most ancient regimes because the composite colour categories had been split. It has solved the historical problem with the linguistic theory of composite colour categories. Besides, it is concluded how the official colours were determined: At first, the official colour might be naturally determined according to the substance of the ruling population. There might be three groups of people in the Far East. (1) The developed hunter gatherers with livestock preferred the white-yellow colour of milk. (2) The farmers preferred the red-yellow colour of sun and fire. (3) The herders preferred the black-grue-yellow colour of water bodies. Later, after the Han-Chinese consolidation, the official colour could be politically determined according to the main property of the five elements in Sino-metaphysics. The red colour has been predominate in China for many reasons. Keywords: colour symbolism, official colours, national colours, five elements, philology, Chinese history, Chinese language, etymology, basic colour terms DOI: 10.3176/tr.2012.3.03 1. -
Views of the Qin Instructor: Anthony Barbieri-Low Tuesdays, 9:00Am-11:50 Am Office: HSSB 4225 Location: HSSB 2252 Office Hours: Mon
History 184R: Views of the Qin Instructor: Anthony Barbieri-Low Tuesdays, 9:00am-11:50 am Office: HSSB 4225 Location: HSSB 2252 Office hours: Mon. 12:00-2:00 pm [email protected] Course Description: The Qin Dynasty (221-207 BC) was the first imperial house to rule the bulk of the territory we now think of as China. The Qin established the pattern for the imperial bureaucratic state that would rule China for the next two thousand years, and its unification of the various written scripts and metal currencies of feudal China ensured the cultural and economic unification of the land as well. But the Qin Dynasty has also been disparaged by later writers for its harsh laws, its excessive labor mobilizations, the autocratic rule of its emperors, and of course, the famous “burning of the books,” one of the most notorious literary inquisitions in history. In this course, students will look at the Qin Dynasty from a wide variety of perspectives. They will come to learn how this brief period in Chinese history has been viewed by later authors and through the lens of contemporary culture. The types of material that students will read or view in this course include primary historical documents, legal codes and casebooks, legends and literature, historical essays, archaeological materials, historical fiction, movies, comic books, and video games. Course Goals: The primary purpose of this course is to train you in the research and writing of a polished historical paper. This course will take you through the stages of a complete research paper -
The Significance and Inheritance of Huang Di Culture
ISSN 1799-2591 Theory and Practice in Language Studies, Vol. 8, No. 12, pp. 1698-1703, December 2018 DOI: http://dx.doi.org/10.17507/tpls.0812.17 The Significance and Inheritance of Huang Di Culture Donghui Chen Henan Academy of Social Sciences, Zhengzhou, Henan, China Abstract—Huang Di culture is an important source of Chinese culture. It is not mechanical, still and solidified but melting, extensible, creative, pioneering and vigorous. It is the root of Chinese culture and a cultural system that keeps pace with the times. Its influence is enduring and universal. It has rich connotations including the “Root” Culture, the “Harmony” Culture, the “Golden Mean” Culture, the “Governance” Culture. All these have a great significance for the times and the realization of the Great Chinese Dream, therefore, it is necessary to combine the inheritance of Huang Di culture with its innovation, constantly absorb the fresh blood of the times with a confident, open and creative attitude, give Huang Di culture a rich connotation of the times, tap the factors in Huang Di culture that fit the development of the modern times to advance the progress of the country and society, and make Huang Di culture still full of vitality in the contemporary era. Index Terms—Huang Di, Huang Di culture, Chinese culture I. INTRODUCTION Huang Di, being considered the ancestor of all Han Chinese in Chinese mythology, is a legendary emperor and cultural hero. His victory in the war against Emperor Chi You is viewed as the establishment of the Han Chinese nationality. He has made great many accomplishments in agriculture, medicine, arithmetic, calendar, Chinese characters and arts, among which, his invention of the principles of Traditional Chinese medicine, Huang Di Nei Jing, has been seen as one of the greatest contributions to Chinese medicine. -
China's Fear of Contagion
China’s Fear of Contagion China’s Fear of M.E. Sarotte Contagion Tiananmen Square and the Power of the European Example For the leaders of the Chinese Communist Party (CCP), erasing the memory of the June 4, 1989, Tiananmen Square massacre remains a full-time job. The party aggressively monitors and restricts media and internet commentary about the event. As Sinologist Jean-Philippe Béja has put it, during the last two decades it has not been possible “even so much as to mention the conjoined Chinese characters for 6 and 4” in web searches, so dissident postings refer instead to the imagi- nary date of May 35.1 Party censors make it “inconceivable for scholars to ac- cess Chinese archival sources” on Tiananmen, according to historian Chen Jian, and do not permit schoolchildren to study the topic; 1989 remains a “‘for- bidden zone’ in the press, scholarship, and classroom teaching.”2 The party still detains some of those who took part in the protest and does not allow oth- ers to leave the country.3 And every June 4, the CCP seeks to prevent any form of remembrance with detentions and a show of force by the pervasive Chinese security apparatus. The result, according to expert Perry Link, is that in to- M.E. Sarotte, the author of 1989: The Struggle to Create Post–Cold War Europe, is Professor of History and of International Relations at the University of Southern California. The author wishes to thank Harvard University’s Center for European Studies, the Humboldt Foundation, the Institute for Advanced Study, the National Endowment for the Humanities, and the University of Southern California for ªnancial and institutional support; Joseph Torigian for invaluable criticism, research assistance, and Chinese translation; Qian Qichen for a conversation on PRC-U.S.