Human Neonatal B Cell Immunity Differs from the Adult Version by Conserved Ig Repertoires and Rapid, but Transient Response Dynamics
bioRxiv preprint doi: https://doi.org/10.1101/2020.08.11.245985; this version posted September 10, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics Bettina Budeus,1,# Artur Kibler,1,# Martina Brauser,1,# Ekaterina Homp,1,# Kevin Bronischewski,1 J. Alexander Ross,1 Andre Görgens,2,3 Marc A. Weniger,1 Josefine Dunst,4,5 Taras Kreslavsky,4,5 Symone Vitoriano da Conceição Castro,2,6 Florian Murke,2 Christopher C. Oakes,7,8 Peter Rusch,9 Dimitrios Andrikos,9 Peter Kern,9 Angela Köninger,9 Monika Lindemann,2 Patricia Johansson,10 Wiebke Hansen,11 Anna-Carin Lundell,12 Anna Rudin,12 Jan Dürig,10 Bernd Giebel,2 Daniel Hoffmann,13 Ralf Küppers,1 Marc Seifert1* 1Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany. 2Institute for Transfusion Medicine, Medical Faculty, University of Duisburg-Essen, Essen 45147, Germany. 3Department of Laboratory Medicine, Karolinska Institute, Stockholm 17177, Sweden. 4Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm 17177, Sweden. 5Center for Molecular Medicine, Karolinska Institute, Stockholm 17177, Sweden 6CAPES Foundation, Ministry of Education of Brazil, Brasília 70610-908, Brazil. 7Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH 43210, USA. 8Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA. 9Department of Gynecology, Medical Faculty, University of Duisburg- Essen, Essen 45147, Germany.
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