Proseek Multiplex Oncology I v296×96 (AM) P35318 Fms-related tyrosine 3 (Flt3L) P49771 (AR) P15514 Folate receptor alpha (FR-alpha) P15328 -1 receptor (TIE2) Q02763 Follistatin (FS) P19883 B-cell activating factor (BAFF) Q9Y275 Furin (FUR) P09958 Cadherin-3 (CDH3) P22223 Growth hormone (GH) P01241 Carbonic anhydrase IX (CAIX) Q16790 Growth/differentiation factor 15 (GDF-15) Q99988 (CEA) P06731 Heparin-binding EGF-like (HB-EGF) Q99075 Caspase-3 (CASP-3) P42574 (HGF) P14210 C-C motif chemokine 19 (CCL19) Q99731 ICOS ligand (ICOSLG) O75144 CD40 ligand (CD40-L) P29965 Immunoglobulin-like transcript 3 (ILT-3) Q8NHJ6 C-X-C motif chemokine 5 (CXCL5 ) P42830 alpha-1 (ITGA1) P56199 C-X-C motif chemokine 9 (CXCL9 ) Q07325 (IFN-gamma) P01579 C-X-C motif chemokine 10 (CXCL10 ) P02778 -1 receptor antagonist (IL-1ra) P18510 C-X-C motif chemokine 11 (CXCL11 ) O14625 Interleukin-2 (IL-2) P60568 C-X-C motif chemokine 13 (CXCL13 ) O43927 Interleukin-6 (IL-6) P05231 Cyclin-dependent kinase inhibitor 1 (CDKN1A) P38936 Interleukin-6 receptor subunit alpha (IL-6RA) P08887 Cystatin-B (CSTB) P04080 Interleukin-7 (IL-7) P13232 Early activation antigen CD69 (CD69 ) Q07108 Interleukin-8 (IL-8) P10145 Epidermal (EGFR ) P00533 Interleukin-12 (IL-12) P29460; P29459 Epididymal secretory protein E4 (HE4 ) Q14508 Interleukin-17 receptor B (IL-17RB ) Q9NRM6 Epithelial cell adhesion molecule (Ep-CAM) P16422 Kallikrein-11 (hK11) Q9UBX7 (EPO) P01588 Kallikrein-6 (KLK6 ) Q92876 E- (SELE) P16581 Latency-associated transforming growth P01137 factor beta-1 (LAP TGF-beta-1) Eukaryotic translation initiation factor 4B (eIF-4B) P23588 Lipopolysaccharide-induced - Q99732 alpha factor (LITAF) Extracellular matrix metalloproteinase inducer P35613 colony-stimulating factor 1 (CSF-1) P09603 (EMMPRIN) Ezrin (EZR) P15311 Matrix metalloproteinase-1 (MMP-1) P03956 Fas antigen ligand (FasL) P48023 -derived growth regulatory protein Q16674 (MIA) FAS-associated death domain protein (FADD) Q13158 MHC class I polypeptide-related sequence A Q29983 (MIC-A)

Table continues on reverse Proseek Multiplex Oncology I v296×96 (MK) P21741 (THPO) P40225 Monocyte chemotactic protein 1 (MCP-1) P13500 (TF) P13726 Myeloid differentiation primary response protein Q99836 TNF-related apoptosis-inducing ligand receptor 2 O14763 MyD88 (MYD88 ) (TRAIL-R2) NF-kappa-B essential modulator (NEMO) Q9Y6K9 Transforming growth factor alpha (TGF-alpha) P01135 NT-3 growth factor receptor (NTRK3) Q16288 Tumor necrosis factor (TNF) P01375 Ovarian cancer-related tumor marker CA 125 Q8WXI7 Tumor necrosis factor ligand superfamily member O43557 (CA-125) 14 (TNFSF14 ) Parkinson disease protein 7 (PARK7) Q99497 Tumor necrosis factor receptor 1 (TNF-R1) P19438 Placenta growth factor (PlGF) P49763 Tumor necrosis factor receptor 2 (TNF-R2) P20333 Platelet endothelial cell adhesion molecule P16284 Tumor necrosis factor receptor superfamily P43489 (PECAM-1) member 4 (TNFRSF4 ) Platelet-derived growth factor subunit B (PDGF P01127 Tumor necrosis factor receptor superfamily P25445 subunit B) member 6 (FAS ) Prolactin (PRL) P01236 Tyrosine-protein kinase Lyn (LYN) P07948 Prostasin (PRSS8 ) Q16651 Tyrosine-protein phosphatase non-receptor type Q9Y2R2 22 (PTPN22) Receptor tyrosine-protein kinase erbB-2 (ErbB2/ P04626 Urokinase plasminogen activator surface receptor Q03405 HER2) (U-PAR) Receptor tyrosine-protein kinase erbB-3 (ErbB3/ P21860 Vascular endothelial growth factor A (VEGF-A) P15692 HER3) Receptor tyrosine-protein kinase erbB-4 (ErbB4/ Q15303 Vascular endothelial growth factor D (VEGF-D) O43915 HER4) Regenerating islet-derived protein 4 (REG-4) Q9BYZ8 Vascular endothelial growth factor receptor 2 P35968 (VEGFR-2) (SCF) P21583 Vascular endothelial statin (VE-statin) Q9UHF1 Tartrate-resistant acid phosphatase type 5 (TR-AP) P13686 Vimentin (VIM) P08670

Miscellaneous Explorative Immune/Inflammatory response

Apoptosis

Protease/ Receptor/ protease receptor inhibitor binding

Cell proliferation, angiogenesis Cell signaling/ migration Cell adhesion Figure 1. Proseek Multiplex Oncology I v296x96 protein biomarker categories.

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