LOS ANGELES SEATTLE ALL AROUND ITALY LA BUONA TAVOLA Cinzia Zuffada Italian Coal Erice: History & Easter Pie With A Leader at JPL Miners Romance Bite

Page 6 Page 9 Page 16 Page 17

N ITIO ED TER EAS

$2.25 CVIII • N. 6 • THURSDAY, MARCH 17, 2016 • GIOVEDÌ 17 MARZOA 2016 mFACEBOOK.COeM/ITALOArMERICANiONEWcSPAPERaitanloamo ericano.org L’Ital.... o Published by L’Italo American Foundation Founded in 1908 ...... PO Box 1287 Monrovia, CA 91017 - Tel: (626) 359-7715 The #1 source for all things Italian since 1908

FEATURES To the Opera via Hollywood PG.2

LIFE & PEOPLE The Legacy of Venice’s Skilled Artisans

PG. 11

LA VITA ITALIANA The Birth of a Wine: The creator of the Fasting Mimicking Diet Valter Longo with Salvatore Caruso 110 years old, the oldest living man in Italy The History of Chianti Classico PG. 12 Valter Longo and his elixir of Y A

L longevity E

D Associate Professor of Oncology program at IFOM, in LAVINIA PISANI L’EDITORIALE

T Gerontology and Biological Milan, Italy, and he invites us to Sciences, as well as the Hanson rethink our alimentary habits. O f the idea of living longer has Chair of at the For over 20 years, Longo has

N L’Italia unita 155

ever intrigued you, Valter University of Southern devoted himself to understanding the cellular and molecular bio - anni fa quando O ILongo’s Fasting Mimicking California (USC), Longo is also Diet may be the secret. director of the Longevity and D PG. 4 era in America

-

che si diventava L italiani A I

R 'anniversario è stato solenne -

E mente festeggiato nel 1911, T Lnel 1961 e nel 2011 rispetti - A vamente in occasione dei 50,100 e

M 150 anni. Questa volta cade il 155° anniversario da quel 17 marzo D 1861, data lontana nel tempo e E

T nella memoria che segnò la procla -

A mazione del Regno d'Italia.

D PG. 27 L'Italo-Americano THURSDAY, MARCH 17, 2016 THURSDAY, MARCH 17, 2016 4 www.italoamericano.org NEWS & FEATURES TOP STO RIES PEOPLE EVENTS “Vegan and Pescetarian diets appear to be ideal for maximizing anti-aging effects”

Continued from page 1 Larson syndrome on Ecuadorian indigenous, that logical mechanism triggered by blocks the growth hormone mimicking and makes them immune from fasting, with the help of his cancer and diabetes, influenced research team. your longevity discoveries? A periodic diet that mimics The collaboration with fasting promotes multi-system Guevara allowed us to confirm regeneration, enhanced cognitive what we strongly suspected from performance and health-span, studies on simple organisms and according to last year’s Cell mice. Jaime is my collaborator, Metabolism publication. There is as well as the personal doctor of more. After studies run on yeast, all the Larson subjects, who have mice and human, it has been the mutation equivalent to that proofed that the mimicking fast - which causes record lifespan ing diet halves tumors, abolished extension on mice. Thus, Jaime cardiovascular diseases, diabetes has been a key collaborator for and reduces significantly the risk our work on the genetics of of Alzheimer. aging and diseases. Obviously, “When normal cells are it’s incredible when you see this starved, the body uses up stores working on people. of glucose and energy to keep Vegetarian, vegan, raw-food them functioning; in response, and fruitarian diets, what do the cells shift into survival mode, you think about these alimen - revving up repair mechanism tary restrictions? and protective processes to resist Vegan and Pescetarian diets anything,” writes Scientific appear to be ideal for many rea - American. sons such as avoiding malnour - Still, it is important to follow ishment, while maximizing anti- a conscious diet recommended aging effects. The majority of and followed by a doctor. In long-lived populations adopted addition to regularly limiting the diets like this. I’m now writing a daily percentage of calories and book in which I explain the ben - reduce the consumption of pro - efits in details. The name of the teins and sugar, the Longo’s phi - book is not finalized yet, but it is losophy suggests to ingest 100 going to be about nutrition, calories per day for up to four- longevity and diseases with a five days, once or twice a year. particular focus on long-term and “Imagine you have pressed a fasting diets. reset button that is immensely As a Longevity Director beneficial to the body,” writes both at the University of La Repubblica. “This goes both Southern California and for healthy and sick people. As IFOM, in Italy, what are the the experiments published last main operating differences year by Cell Stem Cell show, between the two? those who mimicked fasting dur - Both are excellent centers: ing chemotherapy were defeated USC is a leading center for by its toxicity.” aging, while IFOM is a leading The creator of the diet is orig - center for basic research on can - inally from Genoa, Italy. At age Valter Longo is Longevity Director both at The University of Southern California and IFOM in Milan, Italy cer. We are now trying to have 16 he first moved to Chicago and joint programs between the two has been moving around the U.S my work at the clinic. on the normal diet died. For the in the body, then it activates centers such as establishing for more than 30 years now. His Why is the Fasting animal activist out there, we stem cells and after that, during exchange programs for PhD stu - current home base is the City of Mimicking Diet beneficial to only did these experiments re-feeding, it regenerates parts of dents. Los Angeles, CA. those suffering from Cancer, before going to the clinic. Mice organs and systems. We do not What do you consider your What brought you to spe - Alzheimer and Diabetes? And on a normal diet receiving reveal recipes since people greatest accomplishment and cialize in ageing and Alzheimer to others? chemotherapy die because the should either undergo the FMD why? disease? This type of diet is beneficial normal cells of many organs, tested clinically made by L- Starting to succeed using At 19 years old, I quit the jazz because it reprograms the body. including brain and heart, are Nutra (I founded the company basic science to solve major performance program at the Also, it causes multi-system made sensitive by the normal but will donate all shares to char - medical problems. We like to go University of North Texas regeneration and rejuvenation by diet but enter a shielded mode in ity) or go to a fasting clinic. from the molecules all the way to because they wanted me to direct activating stem cells. During our response to the starvation. At What are the contraindica - the clinical demonstration. We a marching band. I refused and studies on mice re-feed after least three clinical trials are sug - tions of this diet? And what is highly focus on the patient and switched to the Biochemistry fasting, the stem cells started to gesting that the same protective the safest way to follow it? on how to use the molecular Department to study aging and proliferate in coordinated mat to effects occur with patients. This diet is not compatible for understanding cell biology to diseases. It was my curiosity that regenerate parts of systems and How does the Fasting anorexic people, diabetics taking solve his/her. It may take up to made me choose classes like organs. We believe the same Mimicking Diet work? any drug, people with metabolic 20 years to develop the proper chemistry and biology, which occurs with humans. We have knowledge of the disorders not compatible with technology to study such things. are vital backgrounds to have in During the research run on molecular connection between fasting. Must be done under For now, my strategy appears to order to study aging. After that, I starving and non-starving major nutrients and the function medical supervision, but after be working with initial clinical spent many years specializing in mice, injected with a megadose of a cell. We exploit this under - the first time a registered dietit - successes in interventions that pathology, immunology, neuro - of chemo, what were the main standing to mimic fasting while ian can follow the patient. help against autoimmunity, dia - biology and endocrinology, differences discovered? allowing mice and people to eat In what way has the collab - betes, cardiovascular disease, among other topics, which have In some cases, all fasted mice about 1/2 of the calories. It first oration with Dr. Jaime cancer, and age-dependent cog - been essential to translate into were alive and well and all mice causes the killing of many cells Guevara, who is studying the nitive decline.