J Jan Ramakers R Fine Chemical Consulting Group
The Fine Chemical Benchmarking Service
Part 1
The Pharmaceutical Fine Chemical Industry - Current Status and Trends -
August 2014
The Fine Chemical Benchmarking Service – Part 1 1
Contents
1. The pharmaceutical Product Life Cycle ...... 3
1.1. The development phase ...... 4 1.2. Success rate and cost of development ...... 7 1.3. Commercial life ...... 14
2. The pharmaceutical value chain ...... 18
2.1. The chain ...... 18 2.2. The value of the chain ...... 20
3. Types of companies and organisations involved ...... 21
3.1 Development ...... 21 3.2 Commercial life ...... 22
4. Company and market characterisation ...... 24
4.1. Pharmaceuticals ...... 24 The market ...... 24 Big Pharma companies...... 28 Biopharmaceutical companies ...... 31 Generic pharma companies ...... 32 Trends ...... 33
4.2. Drug discovery ...... 34 The market ...... 34 The companies ...... 34 Trends ...... 35
4.3. Computational modelling ...... 36 The market ...... 36 The companies ...... 36 Trends ...... 38
4.4. Kilo shops ...... 39 The market ...... 39 The companies ...... 39 Trends ...... 40
4.5. Fine chemicals ...... 41 The market ...... 41 The companies ...... 43 Trends ...... 46
4.6. Contract research ...... 48 The market ...... 48 The companies ...... 48 Trends ...... 50
Jan Ramakers Fine Chemical Consulting Group
August 2014
The Fine Chemical Benchmarking Service – Part 1 2
4.7. Excipients ...... 51 The market ...... 51 The companies ...... 51 Trends ...... 51
5. Structure and development of the business ...... 52
5.1. Pharma – characteristics & development ...... 54 Market development pharmaceuticals 1999 – 2018 ...... 54
5.2. Drug Discovery – characteristics & development ...... 56 Market development drug discovery 1999 – 2018 ...... 56
5.3. Computational Modelling – characteristics & development ...... 57 Market development computational modelling 1999 – 2018 ...... 57
5.4. Kilo shops – characteristics & development ...... 58 Market development kilo shops 1999 – 2018 ...... 58
5.5. Fine Chemicals – characteristics & development ...... 59 Market development fine chemicals 1999 – 2018 ...... 60
5.6. CRO’s – characteristics & development ...... 61 Market development CRO’s 1999 – 2018 ...... 62
5.7. Excipients – characteristics & development ...... 63
6. Opportunities and threats for the fine chemical industry ...... 64
6.1. Opportunities ...... 64 6.2. Threats ...... 65
Jan Ramakers Fine Chemical Consulting Group
August 2014
J Jan Ramakers R Fine Chemical Consulting Group
The Fine Chemical Benchmarking Service
Part 2
The leading manufacturers of Fine Chemicals & Life Science Intermediates
December 2014
The Fine Chemical Benchmarking Service – Part 2 1
Contents
A. Data for 2013 ...... 2
1. Overview ...... 2
1.1. The leading fine chemical companies in 2013 ...... 3 1.2. Profitability in 2013 ...... 16 1.3. Technologies ...... 18 1.4. Grouping by technological breadth ...... 20
2. Company profiles - current ...... 21
2.1. Acros Organics ...... 22 2.2. Aesica ...... 30 2.3. Albemarle ...... 35 2.4. Ampac Fine Chemicals ...... 50 2.5. Arkema ...... 63
2.6. BASF ...... 72 2.7. Boehringer Ingelheim ...... 88 2.8. Borregaard Synthesis ...... 94 2.9. CABB ...... 105 2.10. Cambrex ...... 114
2.11. Dottikon ...... 129 2.12. Dow ...... 140 2.13. DSM ...... 154 2.14. Euticals ...... 177 2.15. Evonik ...... 191
2.16. Isochem ...... 212 2.17. Koei Chemical...... 221 2.18. Lonza ...... 228 2.19. Nippon Soda ...... 260 2.20. Novasep ...... 266
2.21. Omnichem ...... 277 2.22. PCAS ...... 283 2.23. SAFC ...... 294 2.24. Saltigo (Lanxess) ...... 308 2.25. Shasun ...... 326
2.26. Siegfried ...... 331 2.27. Sumitomo ...... 343 2.28. Vertellus ...... 353 2.29. Wacker ...... 362 2.30. WeylChem ...... 374
B. Historic Data ...... 383
Jan Ramakers Fine Chemical Consulting Group
December 2014
The Fine Chemical Benchmarking Service – Part 2 Historic data 383
B. Historic data
Contents historic data
Contents historic data ...... 383
3. Historic data 1999 – 2012 ...... 385
3.1. The leading fine chemical companies in 2012 – full year ...... 386 3.2. The leading fine chemical companies in 2012 – first half ...... 399 3.3. The leading fine chemical companies in 2011 – full year ...... 412 3.4. The leading fine chemical companies in 2011 – first half ...... 425 3.5. The leading fine chemical companies in 2010 – full year ...... 438 3.6. The leading fine chemical companies in 2010 – first half ...... 450 3.7. The leading fine chemical companies in 2009 – full year ...... 462 3.8. The leading fine chemical companies in 2009 – first half ...... 474 3.9. The leading fine chemical companies in 2008 – full year ...... 486 3.10. The leading fine chemical companies in 2007 – full year ...... 498
3.11. The leading fine chemical companies in 2007 – first half ...... 510 3.12. The leading fine chemical companies in 2006 – full year ...... 522 3.13. The leading fine chemical companies in 2006 – first half ...... 533 3.14. The leading fine chemical companies in 2005 – full year ...... 544 3.15. The leading fine chemical companies in 2005 – first half ...... 554 3.16. The leading fine chemical companies in 2004 – full year ...... 564 3.17. The leading fine chemical companies in 2004 – first half ...... 574 3.18. The leading fine chemical companies in 2003 – full year ...... 584 3.19. The leading fine chemical companies in 2003 – first half ...... 594 3.20. The leading fine chemical companies in 2002 – full year ...... 604
3.21. The leading fine chemical companies in 2002 – first half ...... 614 3.22. Leading companies in 2001 – full year ...... 623 3.23. Leading companies in 2001 – first half ...... 632 3.24. Leading companies in 2000 – full year ...... 638 3.25. Leading companies in 2000 – first half ...... 643 3.26. Leading companies in 1999 ...... 649
3.27. Profitability of the leading companies since 2000 ...... 654
3.27.1. Profitability in 2012 – full year ...... 654 3.27.2. Profitability in 2012 – first half ...... 656 3.27.3. Profitability in 2011 – full year ...... 658 3.27.4. Profitability in 2010 – full year ...... 660 3.27.5. Profitability in 2009 – full year ...... 662 3.27.6. Profitability in 2009 – first half ...... 664 3.27.7. Profitability in 2008 – full year ...... 666 3.27.8. Profitability in 2007 – full year ...... 668 3.27.9. Profitability in 2007 – first half ...... 670 3.27.10. Profitability in 2006 – full year ...... 672
3.27.11. Profitability in 2006 – first half ...... 674 3.27.12. Profitability in 2005 – full year ...... 676
Jan Ramakers Fine Chemical Consulting Group
December 2014
The Fine Chemical Benchmarking Service – Part 2 Historic data 384
3.27.13. Profitability in 2005 – first half ...... 678 3.27.14. Profitability in 2004 – full year ...... 680 3.27.15. Profitability in 2004 – first half ...... 682 3.27.16. Profitability in 2003 – full year ...... 684 3.27.17. Profitability in 2003 – first half ...... 686 3.27.18. Profitability in 2002 – full year ...... 687 3.27.19. Profitability in 2002 – first half ...... 688 3.27.20. Profitability in 2001 – full year ...... 689
3.27.21. Profitability in 2001 – first half ...... 690 3.27.22. Profitability in 2000 – full year ...... 691 3.27.23. Profitability in 2000 – first half ...... 692
3.28. Profiles of acquired / previously listed companies ...... 693
3.28.1. Air Products and Chemicals ...... 694 3.28.2. Archimica (i.e. BTP’s fine chemicals) ...... 701 3.28.3. Ascot plc ...... 703 3.28.4. Avecia ...... 707 3.28.5. Axyntis ...... 716 3.28.6. C6 Solutions ...... 725 3.28.7. Chemetall ...... 729 3.28.8. ChemFirst Fine Chemicals ...... 739 3.28.9. Chirex (Rhodia – ChiRex) ...... 742 3.28.10. CU Uetikon ...... 745
3.28.11. Eastman Chemical ...... 756 3.28.12. Finorga ...... 764 3.28.13. Great Lakes ...... 767 3.28.14. KemFine ...... 772 3.28.15. Laporte ...... 783 3.28.16. Orgasynth ...... 787 3.28.17. Oxychem ...... 794 3.28.18. PPG Fine Chemicals ...... 795 3.28.19. Raschig ...... 803 3.28.20. Rhodia ...... 809
3.28.21. Rutherford Chemicals ...... 826 3.28.22. SKW Trostberg ...... 830 3.28.23. Tessenderlo ...... 832 3.28.24. Yule Catto ...... 844 3.28.25. ZaCh System ...... 855 3.28.26. ZellBios ...... 859
Jan Ramakers Fine Chemical Consulting Group
December 2014
J Jan Ramakers R Fine Chemical Consulting Group
The Fine Chemical Benchmarking Service
Part 3
The Fine Chemical Family Tree
November 2012
The Fine Chemical Benchmarking Service – Part 3 1
Contents
1. Introduction ...... 3
2. Major acquisition chains ...... 4
2.1. Clariant ...... 5 2.2. Cambrex ...... 6 2.3. Dow ...... 7 2.4. DSM ...... 8 2.5. Evonik (Degussa) ...... 9 2.6. Rhodia (now Solvay) ...... 10
3. Corporate activity per company ...... 11
3.1. Aesica ...... 12 3.2. Air Products and Chemicals ...... 14 3.3. Albemarle ...... 15 3.4. Ampac Fine Chemicals ...... 17 3.5. Archimica ...... 19
3.6. Ascot ...... 20 3.7. Arkema ...... 21 3.8. Avecia Fine Chemicals ...... 22 3.9. BASF ...... 25 3.10. Borregaard Synthesis ...... 28
3.11. BTP ...... 30 3.12. C6 Solutions (formerly Hickson) ...... 31 3.13. CABB (formerly SF-Chem) ...... 32 3.14. Cambrex ...... 33 3.15. ChemFirst Fine Chemicals ...... 37
3.16. Chemetall...... 38 3.17. ChiRex (Rhodia – ChiRex) ...... 39 3.18. Clariant ...... 40 3.19. Contract Chemicals ...... 44 3.20. CU Chemie Uetikon ...... 45
3.21. Dottikon ...... 46 3.22. Dow ...... 47 3.23. DSM ...... 49 3.24. Eastman Chemical ...... 55 3.25. Evonik ...... 56
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 2
3.26. Finorga ...... 63 3.27. Great Lakes ...... 64 3.28. Honeywell ...... 65 3.29. Inspec ...... 67 3.30. Isochem ...... 68
3.31. ISP ...... 70 3.32. KemFine ...... 71 3.33. Koei Chemical ...... 72 3.34. Laporte ...... 73 3.35. Lonza ...... 74
3.36. Novasep ...... 82 3.37. Omnichem ...... 84 3.38. Orgamol ...... 85 3.39. Orgasynth ...... 86 3.40. PCAS ...... 88
3.41. PharmaZell ...... 90 3.42. PPG Fine Chemicals ...... 91 3.43. Procos ...... 92 3.44. Rhodia ...... 93 3.45. Saltigo (Lanxess) ...... 98
3.46. Shasun ...... 101 3.47. Siegfried ...... 102 3.48. Sigma-Aldrich (SAFC) ...... 104 3.49. SKW Trostberg ...... 108 3.50. Sumitomo ...... 109
3.51. Tessenderlo ...... 110 3.52. Vertellus ...... 113 3.53. Wacker ...... 115 3.54. WeylChem ...... 117 3.55. Yule Catto ...... 120
3.56. ZaCh System ...... 122
Index of all companies ...... 123
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 123
Index of all companies
Axyntis ...... 91 3 AZ Electronic Materials ...... 44
3i Group ...... 75 B
Barclays Private Equity ...... 47 A BASF ...... 12, 26, 89 Bayer ...... 72, 102 Abbott ...... 12 Bayer CropScience AG ...... 102 Abbott Laboratories ...... 26 Beijing Albemarle Yanshan Fine Chemical ACF Chemie ...... 52 Company ...... 15 Acordis Fine Chemicals ...... 114 Bio Science Contract Production ...... 35 Adrian Group ...... 90 Bio*One Capital ...... 81 Aerojet Fine Chemicals ...... 17 BioCatalytics ...... 74 Aesica ...... 12 Biocompatibles ...... 34 Agroferm ...... 63 BioWhittaker ...... 34 Air Products and Chemicals ...... 14 Bitterfeld Wolfen ...... 123 Akzo Nobel ...... 15, 49 bluO ...... 66 Albemarle ...... 15, 21, 39, 55, 98, 121 BMS ...... 52 Albright & Wilson ...... 97 Boehringer Ingelheim ...... 34 Algonomics ...... 83 Boehringer Ingelheim Bioprod Partnership .... 34 All'Chem ...... 91 Boots Pharmaceuticals ...... 12 Allco ...... 71 Borregaard Synthesis ...... 29 Allied Signal ...... 69, 71 Borregaard Taicang Chemicals...... 30 Alpha Bioverfahrenstechnik ...... 106 Borsodchem ...... 72 Alpha Drug India ...... 52 Boston BioSystems ...... 22 Altana ...... 40 BP Antwerp ...... 71 AlzChem ...... 66 BP Barry ...... 71 AlzChem Trostberg ...... 65 Bridgepoint ...... 33 American Pacific Corporation ...... 17 BTP...... 31, 42 Ampac Fine Chemicals ...... 17, 126 Angus Chemical Company ...... 49 Arch Chemicals ...... 24, 85 C Archimica ...... 19, 31, 42, 44 Archport ...... 47 C6 Solutions ...... 32 Argos Soditic ...... 91 CABB ...... 33 Ariel Research Corporation ...... 58 CABB OY ...... 75 ARK Scientific GmbH Biosystems ...... 108 CalaChem ...... 33, 75 Arkema ...... 21 Calaire ...... 115 Armour Polymers Ltd ...... 117 California Peptide Research ...... 84 Arques Industries ...... 87 Cambrex ...... 34, 36, 81, 122 Arsenal Capital Partners ...... 117 Cambrex Zenara ...... 37 Ascot ...... 20, 49, 50 Camlin Fine Chemicals ...... 30 Ashland ...... 64 Capvis ...... 33 Asta Medica ...... 60 CarboTech ...... 121 AstraZeneca ...... 55 CasChem ...... 35 AstraZeneca Specialties ...... 22 Catalytica Pharmaceuticals ...... 52 Atofina ...... 15, 21, 114 Cauldron ...... 41 Auctus Capital Partners ...... 94 CBC Group...... 96 Aurelius...... 33, 73, 75 Celanese ...... 14 Avecia ...... 23, 54, 75 Celanese AG ...... 42 Avecia Fine Chemicals ...... 22 Celgene ...... 34 Aventis ...... 92, 102 Celltech ...... 79 Avesta Biotherapeutics and Research ...... 106 Celltech Biologics ...... 78 AWD Pharma ...... 60
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 124
Central Romana ...... 68 DSM Pharma Products ...... 54 Chelsea Building Products ...... 115 DSM Pharmaceutical Products ...... 16 Chemetall ...... 40 DSM Sinochem Pharmaceuticals ...... 57 ChemFirst Fine Chemicals ...... 15, 39 DSM Special Products ...... 56 Chemie Linz ...... 52 DuPont Crop Protection ...... 115 Chemiesynth Group ...... 124 Durate Pharmaceutica ...... 124 Chiragene ...... 34 Dynamic Synthesis ...... 86 Chiralix ...... 54 Dynamit Nobel ...... 40, 67, 86 ChiRex ...... 41, 97 DyStar ...... 27, 103, 123 Chirosep...... 91 ChiroTech ...... 20, 50 Chloralp ...... 99 E Ciba ...... 27 Cinven ...... 22 E.On ...... 60 Clariant ...... 19, 31, 33, 42, 124 Eastman Chemical ...... 58 Clariant Acetyl Building Blocks ...... 33, 44 Eastman Peboc ...... 58, 59 Clariant Pharmaceutical Fine Chemicals ...... 44 Elf Atochem ...... 21 Clariant’s Custom Manufacturing Business ... 45, EMS Dottikon ...... 48 122 Enichem ...... 114 CoEBio3 ...... 27 Epichem Group ...... 109 Cognis ...... 28 Equateq ...... 28 Colour-Chem ...... 43 Ergon Capital Partners ...... 94 Conti BPC ...... 34 Erie Chem ...... 124 Contract Chemicals ...... 46 Erredue SpA ...... 19 Corden Pharma ...... 116 Euticals ...... 19, 42 Cosan Chemical Corporation ...... 35 Evonik ...... 60, 65 Creapharm ...... 92 Evonik Energy ...... 66 CU Chemie Uetikon ...... 47 Evonik Rexim ...... 66 Cyanamid ...... 26 Excelsyn Molecular Development ...... 68 Cyprus Foote ...... 40 Expansia ...... 92 Cytec ...... 77
F D Farmabios ...... 94 Dalton Pharma Services ...... 84 Feralco ...... 99 DanChem ...... 32 Fine Organics Ltd ...... 65 Danisco ...... 58, 99 Finorga ...... 67, 86 Degussa ...... 60, 61, 117 Floressence ...... 90 Degussa Sanzheng (Yingkou) Fine Chemicals 64 FMC's bioproducts business ...... 34 Degussa-Hüls ...... 60, 112 Framochem ...... 72, 73 Dentsply International ...... 60 Francis ...... 77 Deretil ...... 52 Dipharma ...... 77 Diversa Corporation...... 49 dmc2 ...... 61 G Dottikon ...... 48 Dow Chemical ...... 20, 49, 72 Ganes ...... 106 Dowpharma ...... 50 GEA Pharmaceutical ...... 94 Dr Reddy’s ...... 50 Gencorp ...... 17 DSM ...... 24, 52 Genencor ...... 58 DSM Agro ...... 56 Genencor International ...... 98 DSM Anti-infectives ...... 55 Genentech ...... 79, 81 DSM Anti-Infectives ...... 57 General Electric ...... 69 DSM Biologics ...... 52, 56 Genolife ...... 36 DSM Catalytica Pharmaceuticals ...... 52 Genzyme Transgenics ...... 78 DSM Deretil ...... 56 Gilead ...... 65 DSM Elastomers ...... 57 Gist Brocades ...... 52 DSM Melamine ...... 56 Glaxo Wellcome ...... 41 DSM Minera ...... 55 Granules India ...... 88
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 125
Granules OmniChem ...... 88 JRH Biosciences ...... 108 Great Lakes ...... 68 Jülich Fine Chemicals ...... 119 Gulf Bayport Chemicals ...... 79 K H Kemetyl ...... 29 Haltermann ...... 20, 49 KemFine ...... 25, 33, 75 Hampshire Chemical Corp ...... 49 KemFine Finland ...... 75 Harlow Chemical Company (Harco) ...... 124 KemFine UK ...... 73, 75 Heico Chemicals ...... 35 Kemira ...... 75, 98, 103 Henogen ...... 87 Kerling UK ...... 115 Heubach ...... 23 Knoll ...... 26 Hexachimie ...... 31 Koei Chemical ...... 76 Hexal Synthese ...... 63 Kyowa Hakko ...... 63 Hickson International ...... 32 Hickson PharmaChem ...... 32 Hoechst ...... 119 L Hoechst Fine Chemicals ...... 42 Holland Sweetener Company...... 55 Laboratorios Julián de México ...... 124 Holliday Chemical Holdings ...... 124 Lancaster Synthesis ...... 43 Holliday Dyes & Chemicals ...... 124 Lanxess ...... 57, 102 Honeywell ...... 69 Laporte ...... 60, 61, 71, 77 Honeywell Research & Life Science Solutions 69 Leiras Fine Chemicals ...... 92 Huntsman Corporation ...... 97 Lenzing ...... 71 Hybridon ...... 22 Lonza ...... 37, 78 Lonza Biotec ...... 79 Lubrizol Corporation ...... 24 I LumiTech ...... 34 Lynchem ...... 64 Ian Shott Development ...... 68 IBC Advanced Technologies ...... 23 ICI ...... 14 M ICIG ...... 16, 36, 45, 116, 121, 122 IEP GmbH ...... 37 Marathon Biopharmaceuticals ...... 35 Ilypsa ...... 103 McLaughlin Gormley King Company ...... 118 Imitech ...... 71 Merck ...... 25, 27, 90 INEOS Chlor ...... 99 Merck Sharp & Dohme ...... 12 INEOS ChlorVinyls ...... 115 MG Technologies ...... 40, 86 Inspec ...... 71, 77 Microbia ...... 57 Inspec Mining Chemicals ...... 77 Mitchell Cotts ...... 20, 50 Intergreen ...... 29 Miteni...... 122 International Chemical Investors Group ..... 116 Mitovie Pharma ...... 13 Investcorp ...... 22 Mitsui ...... 113 Iropharm ...... 69, 109 Molecular Medicine BioServices ...... 109 Irotec ...... 34 Monsanto ...... 68, 75 Isochem ...... 72, 73, 75 Isola ...... 121 ISP ...... 74 N
J Nactis ...... 114 Nanosyn ...... 93 Nantong Acetic Acid Chemical Corporation .. 118 James Robinson India ...... 124 Nantong Reilly Chemical Corporation ...... 118 Janssen Pharmaceutica ...... 122 NeoMPS ...... 73 Jayhawk Fine Chemicals ...... 61, 71 NeoResins ...... 54 Johnson Matthey ...... 43, 69 Nepera ...... 34, 35 Jordan Bromine Company ...... 15 NETDA ...... 107 Jordan Dead Sea Industries Company ...... 15 NextPharma Technologies ...... 17
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 126
Nicholas Piramal ...... 99 PPG Fine Chemicals ...... 95 Nobel Explosifs ...... 73 PPG-Sipsy ...... 126 North China Pharmaceutical Corporation ...... 55 ProBioSint ...... 42 Novacap ...... 101 Procos ...... 96 Novartis ...... 83 Prokaria ...... 119 Novasep ...... 86, 99 Proligo ...... 62, 63, 109 Noveon ...... 94 ProSyntest ...... 37 Novochem ...... 102 Protéus ...... 93 NSC Technologies ...... 68 Puragen ...... 23 Nufarm ...... 27 Pyrion ...... 122 Nutrinova ...... 80 Nylstar ...... 100 Q
O Quality Chemicals ...... 39
OM Group ...... 61 Omnichem ...... 88 R Orascom Construction Industries ...... 56 Orelis ...... 99 R5 Pharmaceuticals ...... 12 Orgachim ...... 91 RAG ...... 65 Orgamol ...... 27, 89 Raschig ...... 62 Orgapharm ...... 90, 91 Raylo ...... 65 Orgasynth ...... 90 Raylo Chemicals ...... 61 Orkla ...... 29 Reilly...... 62, 117 Otsuka Chemical ...... 30 Rescom ...... 54 Oxon ...... 60 Rexim ...... 66 Oxxynova ...... 60, 65 Rhodia ...... 41, 46, 97 Rhodia – ChiRex ...... 41 Rhodia Pharma Solutions ...... 105 P Rhône-Poulenc ...... 97 Rhône-Poulenc Rorer ...... 97 Palmer Research ...... 68 Riedel de Haen ...... 69 PCAS ...... 92 Roche ...... 31, 53 PCAS Biosolution ...... 93 Rohm and Haas ...... 51 PCAS-Nanosyn ...... 93 Rohm and Haas Advanced Biosciences ...... 86 PCR ...... 31 Rohner ...... 86, 87 Pemco ...... 29 Rutger’s Speciality Surfactants ...... 121 Penick ...... 106 Rutgers Organics...... 121 Penn Specialty Chemicals ...... 68 Rütgers Organics...... 121 Pentagon Chemicals ...... 68 Rutherford Chemicals ...... 35, 36, 117 Perstorp ...... 82 Pharmaceutical Fine Chemicals ...... 69 Pharmaceutical Fine Chemicals Sarl ...... 69 S Pharmaceutical Resources...... 74 PharmaChem Technologies ...... 87 Sabic ...... 53 Pharmacie Centrale de France ...... 92 Sachem ...... 61 PharmaZell ...... 94 SAFC ...... 108, 109, 110 Pharmophix ...... 110 Salsbury ...... 34 Pharmorphix ...... 109 Saltigo ...... 102, 103 Phillips Petroleum...... 49 Sandoz ...... 42, 94 Phoenix Chemicals ...... 105 Sanofi ...... 67, 77 Pliva ...... 60 Sanofi-Aventis ...... 107 Polaroid’s fine chemicals ...... 74 Sanofi-Synthélabo ...... 67, 86 PolyCarbon Industries ...... 29 Säurefabrik Schweizerhall ...... 33 Polynt ...... 81 Schenectady ...... 77 Polynt SpA...... 82 Schering ...... 92 PolyOrganics ...... 29 Schwarz Pharma ...... 92 PolyPeptide ...... 73 Seal Sands Chemicals ...... 35 PPG ...... 126
Jan Ramakers Fine Chemical Consulting Group
November 2012
The Fine Chemical Benchmarking Service – Part 3 127
Seibu Kasei Co ...... 113 Torcan ...... 22 Seloc France ...... 92 Tosoh Corporatio ...... 55 Sentrachem ...... 49 TotalFinaElf ...... 21 Seres ...... 93 Towerbrook Capital Partners ...... 19, 44 SF-Chem ...... 33, 44 Shanghai SNPE Chemicals ...... 72 Shasun...... 105 U Shasun Chemicals & Drugs ...... 100 Shell Fine Chemicals ...... 71 UCB ...... 13, 80 Shin-Etsu Chemical ...... 43 UCB-Bioproducts ...... 81 Shire Pharmaceutical ...... 56 Ultrafine ...... 108 Shuangling Chemical Industry ...... 114 Union Carbide ...... 49 Sidroga ...... 106 Uquifa ...... 124 Siegfried ...... 106 Sigma-Aldrich ...... 70, 108 Sinochem ...... 57 Sipsy...... 95 V Sisas ...... 26 Sissa ...... 73 VanDeMark Chemical ...... 73 SKW Trostberg ...... 60, 112 Vapi Products Industries ...... 118 Snecma ...... 72 Veba ...... 60 SNPE ...... 49, 72, 75, 114 Velsicol...... 56 Société Béarnaise de Synthèse ...... 92 Vertellus ...... 117 Solvay ...... 10, 101 Vertellus Specialty Materials (India) ...... 118 Stahl ...... 23 Viag ...... 60, 112 Sumika Fine Chemicals ...... 113 Vivante GMP Solutions ...... 84 Sumika-Takeda Agro Manufacturing Co ...... 113 VLG Chem ...... 92 Sumitomo ...... 113 Voridian Company ...... 58 Suven Life Sciences ...... 29 Symyx Technologies ...... 49 Syncom ...... 54 W Syngenta ...... 33, 44, 104 Synopharm ...... 106 Wacker ...... 119 Syntex Agribusiness ...... 31 Wacker Fine Chemicals ...... 120 Syntex Pharmaceuticals ...... 87 Warner-Lambert ...... 32 Synthélabo ...... 67 Weifang Yaxing Chemical Company ...... 103 Synthetics International AG ...... 125 Weyl ...... 121 Synthetics-Uquifa AG ...... 125 WeylChem ...... 16, 36, 116, 121 Synthexim ...... 91 Wind Point Partners ...... 117 Synthon Chiragenics ...... 34 Synthon Chiragenics Corporation ...... 23 Y
T Yule Catto ...... 124
Taile ...... 114 Taile Chemical Industry ...... 114 Z Takeda’s vitamin business ...... 26 Tallin University of Technology ...... 37 Zach System ...... 17 Taminco ...... 14 ZaCh System ...... 95, 126 Tennants ...... 115 Zaltbommel ...... 61 Tessenderlo ...... 21, 73, 114 Zambon ...... 95 Tessenderlo Fine Chemicals Limited ...... 115 Zeeland Chemicals ...... 35 Tessenderlo Kerley ...... 115 ZellBios ...... 94 Tetrionics ...... 108 Zenara Pharma ...... 37 Teva ...... 19, 83 Zeneca ...... 117 Teva Pharmaceuticals ...... 69 Zeneca LSM ...... 22 Th.Goldschmidt ...... 112 Zentiva ...... 107 Tillotts Pharma ...... 38 Zeria Pharmaceutical ...... 38 Topigen Pharmaceuticals ...... 50
Jan Ramakers Fine Chemical Consulting Group
November 2012
J Jan Ramakers R Fine Chemical Consulting Group
The Fine Chemical Benchmarking Service
Part 4
The non-pharma Fine Chemical Industry - Current Status and Trends -
August 2014
The Fine Chemical Benchmarking Service Part 4 – non-pharma markets 3
Contents
1. The chemical industry ...... 4
1.1. Industry structure ...... 4 1.2. Fine Chemicals & performance chemicals ...... 4 1.3. Non-pharma fine chemical market segments ...... 7
2. Detail information for each non-pharma segment ...... 12
2.1. Agrochemicals ...... 12 2.2. Antioxidants ...... 17 2.3. Biocides ...... 18 2.4. Cosmeceuticals ...... 21 2.5. Cosmetics & Toiletries (C&T) ...... 22
2.6. Electronic chemicals ...... 25 2.7. Flavours & Fragrances (F&F) ...... 28 2.8. Food additives ...... 30 2.9. Nutraceuticals ...... 32 2.10. Photographic chemicals ...... 33
2.11. Organic Pigments and Dyes ...... 34 2.12. Plastics additives ...... 35 2.13. Rubber processing chemicals ...... 37
Jan Ramakers Fine Chemical Consulting Group
August 2014