A NEW INTERNATIONAL CONFERENCE & EXHIBITION Smart Synthesis & Advanced Purification State of the Art Processes in Large Scale Production of Pharmaceuticals and Fine Chemicals

22 - 23 April 2013 Hilton Hotel Lyon, France

Attend this conference and learn how novel approaches combining smart multi-step synthesis pathways with advanced purification technologies can deliver the desired high quality product at both development and production scale, in a time-efficient and cost-effective manner.

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www.scientificupdate.co.uk | [email protected] The New International Conference and Exhibition Smart Synthesis & Advanced Purification 22 - 23 April 2013 Hilton Hotel Lyon, France

Who should attend? State of the Art Processes in Large • Process research and Scale Production of Pharmaceuticals development chemists • Organic chemists, process and Fine Chemicals engineers Introduction • Project managers and The complexity of APIs and fine chemicals has been increasing department heads over the years and more and more stringent purity targets • Anyone involved in have to be met to comply with ever tougher regulations. At the chemical development and manufacturing same time, the economic pressure continuously drives down the costs of production. The combination of complexity and • Anyone willing to find out about innovative industrial purity represents a real challenge for the pharmaceutical and purification processes fine chemical manufacturing industry, and traditional synthetic methods often become a bottleneck.

The conference will illustrate how novel approaches combining Fees smart multi-step synthesis pathways combined with advanced purification technologies can deliver the desired high quality Conference Fee £1195.00 product at both development and production scale, in a time- Early Bird save £200.00 efficient and cost-effective manner. Presented by experts Book before 28.2.2013 from several innovating pharmaceutical, agrochemical and fine Exhibitor Fee £1800.00 chemical companies, a number of development and industrial Extra Exhibitor place £500.00 case studies will be presented thereby highlighting how these novel strategies can meet the industry’s evolving challenges. Academic Fee £350.00

Registration includes: How you will benefit from attending? • Attendance for all Bring yourself up to date on current developments and future trends. conference sessions Learn how less conventional, innovative technologies can be applied and • Set of colour conference make the difference, through the presentation of industrial examples. proceedings plus CD Meet and network with the key people in the chemical and • Lunch & refreshments daily pharmaceutical industries. • Access to the exhibition • Place at the networking Reception Venue - Hilton Hotel Lyon, France • FREE poster board 70 Quai Charles De Gaulle, Lyon, 69463, France Tel:+33 4 7817 5050 www.hilton.com/Lyon - Full details of accomodation available on our website.

Further information: scientificupdate.co.uk tel+44 (0)1435 873062 fax +44 (0)1435 872734 [email protected] Already for decades Scientific Update maintains the high quality of their conferences. Akzo Nobel Excellent organisation, top class range of speakers “ and relevant topics. Optimal group size for networking Pfizer We’ve Got Chemistry “ Conference Programme Conference Timings Dr James Bruno, Chemical and Pharmaceutical Solutions, USA Monday 22 April 09.00 - 18.45 Conference in Session Introducing New Technologies in a Regulated Environment 19.00 Welcome Reception Professor Tim Donohoe, Oxford University, UK Tuesday 23 April New Catalytic Reactions Designed to Expedite Organic Synthesis 08.55 - 12.45 Conference in Session Dr Christian Fleury, Novartis Pharma AG, Switzerland 13.30 -17.00 Visit to Novasep Examples of Smart Integration of Purification Techniques in the Synthesis of Drug Substances in Development and Production at Welcome Reception Novartis Pharma AG All delegates are invited to the Welcome Reception which is Dr Pilar Franco, Chiral Technologies Europe, France kindly sponsored by Novasep Preparative Separation of Enantiomers. A Viable Tool for Chemical Development and Manufacturing Novasep Site Visit Mr Stephen Fulton, Syngenta Crop Protection AG, Switzerland A visit to the Novasep Site has “Industrial Scale Chromatography...... are you crazy?” been organised on the afternoon of day two, by invitation only. Dr Jacques-Alexis Funel, Actelion Pharmaceuticals Ltd, Switzerland Practical Synthesis of 5-Phenylbicyclo[2.2.2]oct-5-en-2-one toward L/T Calcium Channel Blocker ACT-280778: Application of Conference Partner the Diels–Alder reaction on kg-scale Novasep proposes cost- effective and sustainable Dr Paul Hellier, Institut de Recherche Pierre Fabre, France synthesis and purification Continuous Processes for the Synthesis of Active Molecules: solutions to produce active Integration with Continuous Downstream Separations ingredients and intermediates Mr Laurent Heusgens & Mrs Leslie Noon, at the required purity for the UCB Pharma, Belguim pharmaceutical, agrochemical, SMB in-the-field Experience after 10 Years of Industrial Production cosmetic, electronic and fine chemical industries. They offer Dr Jean-Francois Marcoux, Novasep, France process development services, Streamlining Production: Smart Synthesis and Purification Combined custom synthesis and/or KEYNOTE PRESENTATION purification services, the supply of purification systems and Dr Roger-Marc Nicoud, Founder of Novasep, France consumables, as well as special Combining Expertise across Life Science Industries to Provide chemicals. Visit the website Optimum Purification Solutions www.novasep.com Dr Thomas Wirth,Cardiff University, UK New Opportunities for Safe Synthesis using Flow Chemistry

The complete programme schedule with full list of speakers and their presentations is published on our website.

Further information: scientificupdate.co.uk tel+44 (0)1435 873062 fax +44 (0)1435 872734 [email protected] Early Bird Save REGISTRATION | SMART SYNTHESIS £200 register before 22 - 23 April 2013 Hilton Hotel Lyon, France 28 February2013

Early Bird Fee SAVE £200 £995.00 Academic Fee £350.00 Conference Fee £1195.00 I would like to present a poster Exhibitor Fee* £1800.00 Please photocopy this form to register additional delegates.

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