A Secondary Metabolite Drives Intraspecies Antagonism in a Gut Symbiont That Is Inhibited by Peptidoglycan Acetylation
bioRxiv preprint doi: https://doi.org/10.1101/2021.06.11.448121; this version posted June 12, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited 2 by peptidoglycan acetylation 3 1,2 1 1,3 4 1 1 4 Mustafa Özçam , Jee-Hwan Oh , Restituto Tocmo , Deepa Acharya , Shenwei Zhang , Silvette Ruiz-Ramírez , 5 Fuyong Li5, Christopher C. Cheng6, Eugenio Vivas7, Federico E. Rey7, Jan Claesen8, Tim Bugni4, Jens Walter5,6,9,10, 6 Jan-Peter van Pijkeren1,11* 7 8 1 Department of Food Science, University of Wisconsin-Madison, Madison, WI, 53706, USA 9 2 Division of Gastroenterology, Department of Medicine, University of California San Francisco, CA, 94141, USA. 10 3 Present Address: Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, 60612, USA 11 4 Department of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53706, USA 12 5 Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada 13 6 Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada; 14 7 Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, 53706, USA 15 8 Department of Cardiovascular and Metabolic Sciences and Center for Microbiome and Human Health, Lerner 16 Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA 17 9 Department of Medicine and APC Microbiome Ireland, University College Cork, Cork T12 K8AF, Ireland; 18 10 School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
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