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Meeting Organizers Meeting Organizers Allan Bradley, Wellcome Trust Sanger Institute, UK Kat Hadjantonakis, Memorial Sloan-Kettering Institute, USA Haruhiko Koseki, RIKEN Research Center for Allergy and Immunology, Japan Michael Shen, Columbia University Medical Center, USA Invited Speakers Keynote Lecture: Shinichi Nishikawa (Kobe) Beddington Lecture: Robb Krumlauf (Stowers Institute) Patterning: Hiroshi Sasaki (Kumamoto); Mark Lewandoski (NCI Frederick) Stem Cells and Germ Cells: Fred de Sauvage (Genentech); Phil Beachy (Stanford) Epigenetics: Atsuo Ogura (Tsukuba); Guoliang Xu (Shanghai) Organogenesis: Lori Sussel (Columbia); Sylvia Evans (UC San Diego) Models of Human Disease: Lee Niswander (Colorado); Alea Mills (Cold Spring Harbor) Genetics and Genomics: Haydn Prosser (Sanger Centre); Kent Lloyd (UC Davis) Technology: Hiromitsu Nakauchi (Tokyo); Anton Wutz (Cambridge) Imaging: Takaharu Okada (Yokohama); Mary Dickinson (Baylor) The Genetics Society of America 9650 Rockville Pike, Bethesda, Maryland 20814-3998 Telephone: (301) 634-7300 • Fax: (301) 634-7079 E-mail: [email protected] • Website: genetics-gsa.org 1 ank you to the following companies for their financial support of this meeting: Platinum Sponsor Silver Sponsors Table of Contents Schedule of Events .................................................................................................................................. 4-5 Map: Asilomar Conference Grounds ......................................................................................................... 7 Exhibits ................................................................................................................................................... 8-9 Plenary/Platform Session Listings ...................................................................................................... 10-23 Poster Session Listings ....................................................................................................................... 24-32 Abstract Listings ................................................................................................................................. 33-85 Speaker and Author Index .................................................................................................................. 86-89 Participant List .................................................................................................................................... 90-94 3 Schedule of Events TUESDAY, October 2 4:00 pm-9:00 pm Registration Merrill Hall 6:00 pm - 7:00 pm Dinner Crocker Dining Hall 7:00 pm - 10:40 pm Plenary/Platform Session 1 - Models of Human Disease Merrill Hall WEDNESDAY, October 3 7:00 am-2:00 pm Registration Merrill Hall 7:30 am - 8:30 am Breakfast Crocker Dining Hall 8:30 am - 12:00 noon Plenary/Platform Session 2 - Patterning Merrill Hall 8:30 am - 12:00 noon Exhibits Merrill Hall 12:00 noon - 1:00 pm Lunch Crocker Dining Hall 1:00 pm - 5:00 pm Exhibits Merrill Hall 2:00 pm - 3:00 pm Beddington Lecture Merrill Hall 3:00 pm - 5:00 pm Poster Session 1 Fred Farr/Klin Even Poster Number Presentations 5:00 pm - 6:00 pm Wine and Cheese Reception Seascape 6:00 pm - 7:00 pm Dinner Crocker Dining Hall 7:00 pm - 10:40 pm Plenary/Platform Session 3 - Stem Cells and Germ Cells Merrill Hall THURSDAY, October 4 7:30 am - 8:30 am Breakfast Crocker Dining Hall 8:30 am - 12:00 noon Plenary/Platform Session 4 - Epigenetics Merrill Hall 8:30 am - 12:00 noon Exhibits Merrill Hall 12:00 noon - 1:00 pm Lunch Crocker Dining Hall 1:00 pm - 5:00 pm Exhibits Merrill Hall 2:00 pm - 3:00 pm Keynote Address Merrill Hall 4 Schedule of Events THURSDAY, October 4 (continued) 3:00 pm - 5:00 pm Poster Session 2 Fred Farr/Klin Odd Poster Number Presentations 6:00 pm - 7:00 pm Dinner Crocker Dining Hall 7:00 pm - 10:20 pm Plenary/Platform Session 5 - Technology Merrill Hall FRIDAY, October 5 7:30 am - 8:30 am Breakfast Crocker Dining Hall 8:30 am - 12:00 noon Plenary/Platform Session 6 - Organogenesis Merrill Hall 9:00 am - 12:00 noon Exhibits Merrill Hall 12:00 noon - 1:00 pm Lunch Crocker Dining Hall 1:00 pm - 6:00 pm Exhibits Merrill Hall 2:00 pm - 3:40 pm Plenary/Platform Session 7 - Imaging Merrill Hall 6:00 pm - 7:15 pm Dinner/Banquet Crocker Dining Hall SATURDAY, October 6 7:30 am - 8:30 am Breakfast Crocker Dining Hall 8:30 am - 12:00 noon Plenary/Platform Session 8 Merrill Hall Genetics and Genomics 12:00 noon - 1:00 pm Lunch Crocker Dining Hall Those who have pre-ordered box lunches should pick them up after breakfast in Crocker Dining Hall 5 Notes 6 Exhibitors As exhibitors at the Mouse Molecular Genetics Conference, the following companies have contributed to the support of this meeting. Registrants are encouraged to visit the exhibits during coffee breaks and other designated times in Merrill Hall to see the new products, publications and services available from these companies. Exhibitors Charles River 251 Ballardville Street Wilmington, MA 01887 781/222-6000 www.criver.com Genetically engineered rodent programs often present unique challenges in managing your research space, funds and animal care resources. Our offsite breeding, quarantine, embryology and genetic testing services can help alleviate whatever constraints you are facing. Through our newly launched Internet Colony Management software (ICM), Charles River offers a sophisticated, easy-to-use portal that offers real-time data access and two-way communication tools to help you manage your colonies. Gene Tools Website: www.gene-tools.com 1001 Summerton Way Phone: (541) 929-7840 Fax: (541) 929-7841 Philomath, OR 97370 Mail: One Summerton Way 541/929-7840 Philomath, OR 97370 USA www.gene-tools.com Gene Tools manufactures Morpholino oligos for blocking translation, modifying splicing or inhibiting miRNA activity. Morpholinos are used in cell cultures, embryos or, as Vivo-Morpholinos, in adult animals. Morpholinos are effective, specific, stable and non-toxic. Backed by Ph.D.-level customer support, Gene Tools designs and synthesizes Morpholinos and offers cytosolic delivery options Taconic One Hudson City Centre Hudson, NY 12534 518/697-3965 www.taconic.com Taconic, a leading provider of life sciences solutions to researchers worldwide, offers innovative animal models and scientific services for in vivo biomedical studies. Taconic's wide range of advanced solutions include custom model design, generation and production, off-the-shelf model repositories, compound profiling, imaging, phenotyping, contract research, genetic monitoring and health testing. 8 Exhibitors The Jackson Laboratory 600 Main Street Bar Harbor, ME 01609 207/288-6029 www.jax.org The Jackson Laboratory is a world leader in mammalian genetics research. Through JAX® Mice & Services, we provide more than 5,000 mouse strains and a comprehensive suite of research services. The Jackson Laboratory also serves as an international hub for scientific information, conferences, training and education. Transnetyx, Inc. 8110 Cordova Rd. Suite 119 Cordova, TN 38016 901/507-0476 www.transnetyx.com Transnetyx Inc. provides fully automated genotyping services for screening genetically modified mouse, rat, and zebrafish models. Having tested over 5 million samples worldwide at 99.98% accuracy, Transnetyx guarantees the turnaround time and accuracy of its genotyping results. The service frees up time for your lab to focus on research, while improving colony management and the integrity of your data. 9 Plenary/Platform Sessions 2 Morahan . 1) Skin Carcinogenesis Lab, QIMR, Brisbane, Qld, Australia; 2) Centre for Diabetes Research, WAIMR, Tuesday, October 2 7:00 pm–10:40 pm The University of Western Australia, Perth, Australia; 3) Merrill Hall Dermatology Research Centre, UQ School of Medicine, Brisbane QLD. Plenary/Platform Session 1 - 8:50 pm - Break Models of Human Disease 6 - 9:10 Chair: Lee Niswander, University of Colorado School of The (uro)chordate-specific Gumby gene governs Medicine angiogenesis and modulates Wnt signaling. Elena 1,2 1,2 1,2 Rivkin , Stephanie M. Almeida , Teresa A. MacLean , 1 - 7:00 1 1,2 Gang Xie , Sabine P. Cordes . 1) Samuel Lunenfeld Exploring Neural Tube Closure via Genes, Research Institute, Toronto, Ontario, Canada; 2) Environment, and Imaging. Lee Niswander. Pediatrics, Department of Molecular Genetics, University of Univ of Colorado School of Medicine, Aurora, CO. Toronto, 1 King’s Crescent, Toronto, ON Canada. 2 - 7:30 7 - 9:30 A gene within the modifier locus, Tgfbm3, regulates Molecular pathogenesis of Joubert Syndrome and signal transduction via TGF-β type I receptor to related disorders. Tamara Caspary1, Holden modify vascular phenotypes in mice and in HHT 2 1,3 2 1 1 Higginbotham , Laura E. Mariani , Tae-Yeon Eom , patients. Kyoko Kawasaki , Sylvia Espejel , Tom 1 1 1 1,2 1 1 1 Miao Sun , Vanessa L. Horner , Alyssa B. Long , Eva S. Letteboer , Michael Benzinou , Marie Lee , Ritu Roy , 2 Anton . 1) Dept. of Human Genetics, Emory University Hans Kristian Ploos van Amstel2, Cornelius School of Medicine, Atlanta, GA; 2) The UNC Westermann3, Rosemary Akhurst1. 1) HDFCCC, UCSF, Neuroscience Center, The University of North Carolina San Francisco, CA; 2) Department of Medical Genetics, School of Medicine, Chapel Hill, NC; 3) Graduate University Medical Centre, Utrecht, The Netherlands; 3) Program in Neuroscience, Emory University, Atlanta, St. Antonius Ziekenhuis, Nieuwegein The Netherlands. GA. 3 - 7:50 8 - 9:50 Phenotypic and Molecular Analyses of Genetic analysis of Down syndrome in mice. Chunhong Different vangl2 Mutants Demonstrates
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