Reference Materials for Clinical, Forensic and Sports Drugs

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Reference materials for clinical, forensic and sports drugs applications 2011/2012 For further information, or if you require substances or materials not currently listed please contact one of our local sales ofﬁces.

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Standards

Excellence through measurement Dear Colleague and Researcher,

Welcome to the new 2011/12 LGC Standards catalogue for “Reference materials for clinical, forensic and sports drugs applications”.

First of all, thank you to all our existing and welcome to all new customers. This paper catalogue is an extract of the full portfolio of materials offered by LGC Standards. It is primarily targeted at laboratories and scientists working in the fields of clinical, forensic and sports drugs testing, but also has relevance to many other laboratory processes. This paper copy provides a summary of materials available at the time of printing (August 2011).

Since the last edition of this catalogue, LGC Standards has continued to expand the range of materials and products available to end users. This new expanded edition includes:

• The New LGCFOR range of solid drugs and metabolites produced by our own laboratories in Luckenwalde, near Berlin

• A growing portfolio of “Legal Highs” or “Research Chemicals” consolidated from suppliers over the world

• An increased range of pure drug materials from Cerilliant, National Measurement Institute of Australia and other reference material producers

• Significant additions to the range of matrix materials calibrators and controls

Our product range is constantly expanding. If you are unable to find the specific drug, metabolite labelled material or matrix-matched substances, please contact your local country representative and we will endeavour to meet your specific needs.

LGC Standards is Europe’s most comprehensive source of reference materials from the world’s leading producers. Our many years’ experience in reference materials and associated analysis enables us to provide high levels of customer service and technical support. This experience, in combination with our network of European offices and relationships with key reference materials suppliers throughout the world allows us to provide you with short delivery times and customer support on the differing requirements for the importation of controlled and uncontrolled reference materials.

Thank you once again for your custom over the last year. We always value feedback on our customer service and look forward to hearing from you.

Regards

LGC Standards team Content

Content Introduction 7

Availability of products 7 Handling and safety 7 Controlled substances 7 General ordering information 7 Clinical applications 13

Blank matrix materials 13 Coagulation factors 14 Drugs 14 Drugs in serum 14 Electrolytes 15 Electrolytes in serum 15 Enzymes 16 Enzymes in serum 17 Metabolites and substrates 18 Metabolites and substrates in serum 19 Metabolites and substrates in urine 22 Non-electrolyte metals in serum 22 Non-electrolyte metals 22 Non-electrolyte metals in blood 22 Non-electrolyte metals in urine 23 Non-peptide hormones 23 Non-peptide hormones in serum 24 Occupational health and hygiene materials in blood 25 Occupational health and hygiene materials in serum 27 Occupational health and hygiene materials in urine 28 Occupational health and hygiene materials in other matrices 29 Proteins 30 Proteins in blood 31 Proteins in serum 31 Proteins in other matrices 32 Veterinary materials 32 Vitamins and micronutrients 33 Various control materials 34 Blood cell size reference material 37 Forensic applications – Alcohol 41

Primary reference materials 41 Secondary reference materials 42 Working reference materials 43 Alcohol congeners in water 45 Ethanol in serum 46 Alcohol congeners in serum 49 Ethanol in blood 50 Markers for identification of ethanol use 50 Forensic applications – pure materials 53

Powder materials produced by LGC Standards 57 Drugs of abuse and metabolites of forensic interest 82

Drugs of abuse and metabolites 82 Explosives 162 Phytos 168 Antifungal drugs 174 Antiviral drugs 175 Molecular biology products 176

Edition 2011/2012 A wide variety of substances for Therapeutic Drug Monitoring available on request! 5

Content

Forensic applications - drugs in blood, hair, serum, urine 181

Anticonvulsant drugs 181 Antidepressiva 181 Antiepileptics 182 Barbiturates in serum 182 Benzodiazepines 182 Benzoylecgonine 183 Buprenorphines 184 Cannabinoids 184 CDT 184 Cotinine 185 Meperidine 185 Metabolites and substrates in urine 185 Neuroleptics 185 Opiates 186 Drugs used in opiate substitution therapies 187 Therapeutic drug monitoring 188 Tricyclic antidepressants 189 Various drugs of abuse 190 Sports drugs and steroids 198

Ordering of certified reference materials for sports drugs analysis 198 Anabolic steroid reference materials 198 1-Androstendione 198 Aromatase inhibitors 198 Selective estrogen receptor modulators (SERMs) 198 Bolasterone metabolites 198 Boldenone and metabolites 198 Calusterone and metabolites 199 Catecholamines 199 Clostebol metabolite 199 Danazol metabolite 199 Drostanolone metabolites 199 Endogenous steroids 199 Estrogen antagonist 200 Finasteride metabolite 200 Fluoxymesterone and metabolites 200 Formebolone metabolite 200 Furazabol metabolite 200 Growth promotants and metabolites 200 Aromatase inhibitors 201 Hydroxysteroids 201 Mesterolone metabolites 201 Methenolone and metabolites 202 Methandienone and metabolites 202 Methyldienolone 203 Methyltestosterone and metabolites 203 17alpha-Methyl-1-testosterore 203 Nandrolone and metabolites 203 Norbolethone and metabolites 205 Norethandrolone and metabolites 205 Oral turinabol and metabolites (dehydrochloromethyltestosterone) 205 Oxandrolone metabolite 206 Prohormones and metabolites 206 PDE-5 Inhibitors 206 Selective estrogen receptor modulators (SERMs) 206 Anti-estrogenic substances (others) 206 Stanozolol and metabolites 206 Stimulants 207 Suppressor of estrogen biosynthesis 208 1-Testosterone 208 Tetrahydrogestrinone and precursors 208 Trenbolone metabolite 209 Testosterone and metabolites 209 Others 211 Commercial materials (not certified by NMIA) 212 Steroid matrix reference material 212 WADA funded sports drug testing materials 213 Proficiency testing schemes 217

6 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Introduction

Availability of products If you are seeking a product which is not listed in this catalogue, please let us know. We will endeavour to trace the material for you and add the product to future catalogues. Items listed in the catalogue may not always be available at the time of ordering. Should this situation arise, an LGC Standards representative will contact you and, if possible, an alternative product will be suggested. Once a particular batch of a given CRM is sold out, there may be a considerable delay before a replacement is available. The analytical data mentioned with the specific products were exact at the time of print. Replacement products may differ in analytical profile and analyte value. For critical and sensitive analytical procedures, where the use of a reference material is essential and demanded by regulations, customers are recommended to establish the use of two reference materials from different producers.

Handling and safety The correct handling for the intended use of RMs and CRMs is described in instructions, certificates, reports, and other product accompanying documents. Please note that it is important to ensure sufficient homogeneity if RMs must be reconstituted, e.g. by dissolving lyophilised material, or diluting samples. Furthermore, regard has to be paid to the amounts recommended in the instructions, because a reduction in the sample size might not correspond to the certified quality parameter. During opening of containers any contamination must be strictly avoided. Opened containers must be closed tightly to avoid any influence of humidity and protected from light. It is recommended that unopened containers are stored in the same manner. Some clinical, forensic and toxicological RMs are classified as hazardous. All necessary safety information, including possible risks to health, are described in detail in the certificates of analysis, reports and other accompanying documents. Instructions on how to handle these hazardous RMs or hazardous materials containing RMs, are given in detail in the MSDSs. Any hazardous RMs should only be handled by a specially trained technician or member of staff. All RMs and CRMs based on human body fluids are tested for infectious diseases as specified in the accompanying documents. However, as no test method can offer complete assurance, all human samples should be handled at bio-safety level 2 conditions. All reference substances and standards in this catalogue are for laboratory analytical use only and not for use in humans.

Controlled substances A number of the forensic reference substances described in this catalogue, notably narcotics, tranquillisers, precursors and drugs of abuse, are controlled substances. Anabolic steroids are also considered as controlled substances in certain countries. The purchase, possession and use of controlled substances is subject to national and international regulations designed to limit their abuse. It is the responsibility of the customer to obtain any authorisation necessary to purchase and possess controlled substances, in compliance with the laws of the importing country, before ordering. However, LGC Standards can assist you in completing the necessary procedures and documentation The complex administration associated with the supply and possession of controlled materials makes it necessary for LGC Standards to ensure all customers requiring controlled substances are aware of all the relevant national requirements, the associated charges and consequential delivery times. Customers wishing to obtain controlled substances should therefore contact their LGC Standards sales office before ordering, and clarify with the sales specialists at LGC Standards the procedure to be followed, and the exact cost. All orders for controlled substances must be provided in writing and signed by an authorised person and must be accompanied with the original import permit and/or possession permit. Please send the order and all related documents to the LGC Standards sales office that is responsible for your country.

General ordering information Prices and delivery procedures are shown in the price list that accompanies this catalogue, or are available from your local LGC Standards sales office. For products requiring special delivery procedures (cooled shipping, special licensing, controlled substances, etc.) additional charges apply. Please check with your local LGC Standards sales office for detailed procedures and transport charges where applicable. Unless agreed in advance and in writing, orders are accepted only against LGC Standards’ standard terms and conditions of sale. Once delivered to the customer, reference substances are non-returnable. For this reason it is very important for users to be certain that the product ordered meets their needs. LGC Standards’ technical staff is available to advice on the use and suitability of a particular product. Customers requiring assistance with the use or application of a particular reference substance should contact their local LGC Standards office, contact details are provided at the beginning of this catalogue.

Edition 2011/2012 A wide variety of substances for Therapeutic Drug Monitoring available on request! 7

Introduction

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8 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Reference materials for clinical applications Europe´s most comprehensive source of reference materials

LGC Standards combines expertise in analytical science, Environmental and experience in international standards, to offer Food, beverages and laboratories throughout Europe the ideal solution to agriculture sourcing high quality certified reference materials. Matrix materials Our expert technical support staff provide unrivalled know- Clinical and forensic ledge in the use of certified reference materials across a broad range of analytical activities. ATCC cultures and bioproducts

• Partnerships with the world´s key producers of RMs Biology & life sciences • Production of pharmaceutical impurities Pure materials • Expert local customer service and technical support Pharmaceutical • Supply of all major pharmacopoeia and RMs Phytochemicals • Assistance in finding the right materials to suit your needs Chromatography • Over 25 000 reference materials in our range High purity solvents and acids For further information or to receive any one of our Industrial materials catalogues please contact your local office or visit our website. Proficiency testing schemes

www.lgcstandards.com CERTIFICATE OF ANALYSIS Additional Material Data ® Concentration 1 Uncertainty 2 ERM - DA120a Constituent (μmol/L) (μmol/L)

Frozen Human Serum – Trace Metals Copper 18.18 0.53 (k=2.1) Certified value 1,2 Uncertainty 3 Constituent Selenium 0.830 0.038 (k=2.2) (μg/kg) (μg/kg) Copper 1 130 33 (k=2.1) Zinc 10.30 0.52 (k=2.1)

Selenium 64.1 3.0 (k=2.2) 1) The concentration and uncertainty have been calculated using the density of serum: 1.0226 kg/L, expanded uncertainty (k = 2): 0.0203 kg/L measured at LGC and molar masses of 63.546 g/mol, 78.96 g/mol and 65.38 g/mol for copper, Zinc 658 33 (k=2.1) selenium and zinc respectively (G. Audi and A.H. Wapstra, The 1993 atomic mass evaluation, Nucl Phys A565 (1993) 1- 65.). 1) The certified values are mass fraction determined using isotope dilution mass spectrometry (IDMS). 2) The quoted uncertainty is the half-width of the expanded uncertainty interval calculated using a coverage factor, k, which 2) The certified values are considered traceable to the SI through the use of pure reference materials (see gives a level of confidence of approximately 95 %. page 3).

3) The quoted uncertainty is the half-width of the expanded uncertainty interval calculated using a coverage factor, k, which gives a level of confidence of approximately 95 %. DESCRIPTION OF THE SAMPLE Human serum from a single donor was prepared from blood obtained at the Royal Surrey County Hospital This certificate is valid for 3 months from the date of shipment provided the sample is stored under the (Guildford, UK). Five donations were taken, with a minimum of 13 weeks between each donation. The blood recommended conditions. was allowed to clot at room temperature, centrifuged, and the serum pipetted into an acid washed container which was then stored frozen at -70 °C 10 °C. Each batch of serum collected was added directly into the The minimum amount of sample to be used is 0.5 g. same bottle. The ‘clean’ serum was mixed thoroughly and then 1.1 mL dispensed into 2 mL plastic screw- cap Nalgene® cryovials (Jencons, Leighton Buzzard, UK). NOTE European Reference Material ERM®-DA120a was produced and certified under the responsibility of LGC Approximately 1000 units of the candidate reference material were produced, which were stored at according to the principles laid down in the Technical Guidelines of the European Reference Materials® co- -70 °C ± 10 °C. operation agreement between BAM-LGC-IRMM. Information on these guidelines is available on the Internet (http://www.erm-crm.org). INTENDED USE Accepted as an ERM®, Teddington, December 2010. This reference material is intended for use in the validation of new and existing methods, and monitoring the performance of methods, commonly used in clinical laboratories to determine the important trace elements Signed: copper, selenium and zinc in human serum samples. It can also be used in the training and evaluation of staff. Dr Derek Craston, UK Government Chemist The material is clinically relevant since it closely matches the lower level of the normal range for serum LGC Limited selenium in the population. Queens Road Teddington Middlesex ANALYTICAL METHOD USED FOR CERTIFICATION TW11 0LY, UK The analysis was carried out using an Agilent 7500ce ICP-MS operating in gas mode. Helium was the cell gas for the copper and zinc isotopes; hydrogen was the cell gas for the selenium isotopes. Each analysis comprised 10 x 100 replicate ratio measurements of the 63Cu/65Cu, 66Zn/67Zn and 78Se/77Se ratio.

4005

ERM® - DA120a ERM® - DA120a Page 1 of 5 Page 2 of 5

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Agilent 7500ce ICP-MS Parameters HOMOGENEITY RF Power (W) 1520 The material was tested for homogeneity by analysing randomly selected 0.5 g samples for copper, selenium and zinc using the method detailed above. The material was judged to be homogeneous as the variation Carrier Gas (L/min ) 0.88 between the samples tested was not significantly greater than the method variation. Make-up Gas (L/min) 0.25 STABILITY Sampling Depth (mm) 7.5 Nebuliser Quartz micromist The nature of the material is such that deterioration is not anticipated over the life of the material stored under the recommended conditions. Spray Chamber Quartz Scott-type cooled to 2 ºC Cell Gas He (mL/min) 4.4 ANALYTICAL METHOD USED FOR THE DETERMINATION OF DENSITY The density of the serum was determined in order to calculate the concentration on a unit/volume basis. Cell Gas H (mL/min ) 4.4 2 Water and 10 serum vials were placed in a water bath at (20 ± 0.02) C for 2 hours. An Eppendorf Multipipette was calibrated, using high purity water and a calibrated balance, to dispense 0.5 mL. The weight of 0.5 mL of serum was determined by dispensing 0.5 mL portions into a pre-weighed empty container. This Primary calibration materials were purchased from NIST: SRM 3114 (Copper - lot number 011017), SRM process was repeated 10 times for water and 10 times for the serum (each from a different serum vial). 3168a (Zinc - lot number 080123) and SRM 3149 (Selenium - lot number 992106). 77 65 Se and Cu enriched isotope spikes were obtained as metal from AEA Technology plc (Harwell, Didcot, PARTICIPANTS 67 Oxfordshire, UK), and dissolved in nitric acid (HNO3). A Zn spike was obtained as a metal from Oak Ridge The Royal Surrey County Hospital collaborated with LGC in the production and characterisation of this National Laboratory (Oak Ridge, Tennessee, USA) and dissolved in HNO3. The concentration of copper, selenium and zinc in the spikes were determined by reverse isotope dilution using the primary standard as material, through their proficiency testing scheme, the Trace Elements Quality Assurance Scheme (TEQAS). calibrant. This collaboration included the preparation of materials and the provision of confirmatory data. Human Serum Certified Reference Material BCR 637 was used as a matrix quality check for selenium and SAFETY INFORMATION zinc. Seronorm Level I was used as a matrix quality check for copper. Single element standard solutions were used as a calibration check: selenium and zinc from Ultra Scientific (Kingstown, RI, USA), copper from The material is of human origin and should be handled with adequate care. The material was tested for Romil (Cambridge, UK). HIV ab, Hep B Surface Ag and Hep C. All were found to be negative. Ten vials of the material were defrosted and equilibrated to room temperature. Each vial was analysed in For further details refer to the safety data sheet. duplicate, 0.3 g of a mixed spike (77Se, 65Cu, 67Zn) was added to 0.5 g of serum and diluted to 10 g with 1 % HNO3. INSTRUCTIONS FOR USE Prior to use, the material should be thoroughly thawed by equilibration at room temperature for at least CONFIRMATORY DATA 2 hours, and mixed by inverting the vial several times. LGC has no data on the effect of further freezing and thawing of the material before use, and therefore it is recommended that, after opening, the material is The Royal Surrey County Hospital organises a proficiency testing scheme, the Trace Element Quality stored at refrigerator temperature (5 ± 4 °C), and used within 1 month. Assurance Scheme (TEQAS) in which over 100 laboratories participate. Serum ERM®-DA120a was used for one round of the TEQAS scheme for the determination of copper, selenium and zinc, in which 50 STORAGE laboratories participated. The results are shown in the table below. The material should be stored at (-20 ± 5) °C in the original closed vial until it is first opened. TEQAS results

Constituent Number Assigned value Standard deviation of results μmol/L μg/kg μmol/L μg/kg Copper 47 17.6 1096 1.5 93

Selenium 33 0.794 61.3 0.076 5.9

Zinc 46 9.9 632 2.0 128

ERM® - DA120a ERM® - DA120a Page 3 of 5 Page 4 of 5

LEGAL NOTICE

The values quoted in this certificate are the best estimate of the true values within the stated uncertainties and based on the techniques described herein. No warranty or representation, express or implied, is made that the use of the product or any information, material, apparatus, method or process which is the subject of or referred to in this certificate does not infringe any third party rights. Further, save to the extent: (a) prohibited by law; or (b) caused by a party's negligence; no party shall be liable for the use made of the product, any information, material, apparatus, method or process which is the subject of or referred to in this certificate. In no event shall the liability of any party exceed whichever is the lower of: (i) the value of the product; or (ii) £500,000; and any liability for loss of profit, loss of business or revenue, loss of anticipated savings, depletion of goodwill, any third-party claims or any indirect or consequential loss or damage in connection herewith is expressly excluded.

Production of this reference material and certificate was funded by the UK National Measurement System.

This certificate may not be published except in full, unless permission for the publication of an approved extract has been obtained in writing from LGC Limited. It does not of itself impute to the subject of measurement any attributes beyond those shown by the data contained herein.

ERM® - DA120a Page 5 of 5

Queens Road, Teddington, Middlesex TW11 0LY Tel: +44 (0)20 8943 7000 Fax: +44 (0)20 8943 2767 Web: www.lgcgroup.com Clinical applications

Clinical applications Blank matrix materials

Code Product Unit ME 40161 Human whole blood control 10 x 2.5 mL Native human lyophilised whole blood control (Medidrug Basis-line VB) can be used for base line determination in different applications, as negative control or as dilution medium of concentrated blood from patients. ME 40151 Human serum control 10 x 2.5 mL Native human lyophilised serum control (Medidrug Basis-line S) can be used for base line determination in different applications, as negative control or as dilution medium of concentrated serum from patients. DTI-600-1 OraFlx negative - synthetic saliva 1 L A synthetic, non-biological, homogeneous saliva that can be used as negative control or as dilution medium of concentrated samples. Formulated to avoid issues with ion interference, foam and infection risk.

DTI-600-2 OraFlx negative - synthetic saliva 10 mL A synthetic, non-biological, homogeneous saliva that can be used as negative control or as dilution medium of concentrated samples. Formulated to avoid issues with ion interference, foam and infection risk.

AC- Blank control, urine 10 x 5 mL UR15.025.005.001 Analytes Matrix verification Amphetamine ...... x Diazepam ...... x d-Methamphetamine ...... x Bromazepam ...... x MDMA 3,4-Methylenedioxymethamphetamine ...... x Nordiazepam ...... x MDA 3,4-Methylenedioxyamphetamine ...... x Oxazepam ...... x MD(E)A 3,4-Methylenedioxyethylamphetamine ...... x Temazepam ...... x Cocaine ...... x Midazolam ...... x Benzoylecgonine ...... x Lorazepam ...... x Ecgoninemethyl ester ...... x THC 9-Tetrahydrocannabinol ...... - Morphine ...... x 11-OH-THC 11-OH-9-Tetrahydrocannabinol ...... - Codeine ...... x THC-COOH 11-nor-9-THC carbonic acid ...... x Dihydrocodeine ...... x Buprenorphine ...... x 6-MAM 6-Monoacetylmorphine ...... x Norbuprenorphine ...... x 7-Aminoflunitrazepam...... x Methadone ...... x Flunitrazepam...... x EDDP 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine . x Clonazepam ...... x Creatinine ...... x

ME 40201 Human urine control 9 x 5 mL Native human lyophilised urine control (Medidrug Basis-line U) can be used for base line determination in different applications, as negative control or as dilution medium of concentrated urine from patients. CER-720-1 Synthetic urine 1 L (Surine TM - negative urine control) CER-720-2 Synthetic urine 50 mL (Surine TM - negative urine control) CER-720-3 Synthetic urine 5 mL (Surine TM - negative urine control) DTI-710 Surine E - synthetic urine for trace metals 1 L A synthetic, non-biological, homogeneous urine specifically designed for trace metals analysis at low concentrations. Formulated to avoid issues with odor, foam and disposal issues associated with human urine.

DTI-766 Surine negative for blind quality controls 60 mL A synthetic, non-biological, homogeneous urine specifically designed for use as a blind negative quality control urine specimen. Formulated to avoid issues with ion interference, foam and odor.

AC- Blank control, serum 10 x 2.5 mL SE015.025.010.001 This material consists of pooled, blank, lyophilized serum and is intended for use as a negative control for laboratories. It is suitable for use as a matrix blank quality control material Analytes matrix verification Amphetamine ...... x Diazepam ...... x d-Methamphetamine ...... x Bromazepam ...... x MDMA 3,4-Methylenedioxymethamphetamine ...... x Nordiazepam ...... x MDA 3,4-Methylenedioxyamphetamine ...... x Oxazepam ...... x MD(E)A 3,4-Methylenedioxyethylamphetamine ...... x Temazepam ...... x Cocaine ...... x Midazolam ...... x Benzoylecgonine ...... x Lorazepam ...... x Ecgoninemethyl ester ...... x THC 9-Tetrahydrocannabinol ...... x Morphine ...... x 11-OH-THC 11-OH-9-Tetrahydrocannabinol ...... x Codeine ...... x THC-COOH 11-nor-9-THC carbonic acid ...... x Dihydrocodeine ...... x Buprenorphine ...... x 6-MAM 6-Monoacetylmorphine ...... x Norbuprenorphine ...... x 7-Aminoflunitrazepam...... x Methadone ...... x Flunitrazepam...... x EDDP 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine ..x Clonazepam ...... x Creatinine ...... -

Edition 2011/2012 A wide variety of substances for Therapeutic Drug Monitoring available on request! 13

Clinical applications

Code Product Unit AC- Blank control, whole blood 10 x 2.5 mL WH015.025.015.001 Blancheck consists of blank lyophilized human whole blood and is intended for use as a negative control for laboratories. It is suitable for use as a matrix blank quality control material.

Analytes matrix verification Amphetamine ...... x Diazepam ...... x d-Methamphetamine ...... x Bromazepam ...... x MDMA 3,4-Methylenedioxymethamphetamine ...... x Nordiazepam ...... x MDA 3,4-Methylenedioxyamphetamine ...... x Oxazepam ...... x MD(E)A 3,4-Methylenedioxyethylamphetamine ...... x Temazepam ...... x Cocaine ...... x Midazolam ...... x Benzoylecgonine ...... x Lorazepam ...... x Ecgoninemethyl ester ...... x THC 9-Tetrahydrocannabinol ...... x Morphine ...... x 11-OH-THC 11-OH-9-Tetrahydrocannabinol ...... x Codeine ...... x THC-COOH 11-nor-9-THC carbonic acid ...... x Dihydrocodeine ...... x Buprenorphine ...... x 6-MAM 6-Monoacetylmorphine ...... x Norbuprenorphine ...... x 7-Aminoflunitrazepam ...... x Methadone ...... x Flunitrazepam ...... x EDDP 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine . x Clonazepam ...... x Creatinin4 ...... - Coagulation factors ERM-AD148 Thromboplastin, bovine (OBT/79) Amp. The sample is the lyophilised form of an 2.2 g aliquot of bovine brain thromboplastin combined and is intended for prothrombin time determination on blood plasma. It is kept under vacuum in sealed glass ampoules. Parameters of the calibration line Prothrombin time slope ...... 1.011 ± 0.015 Prothrombin time intercept ...... - 0.321 ± 0.025

ERM-AD149 Thromboplastin, rabbit Amp. The sample is the lyophilised form of an 0.5 mL aliquot of the extract of rabbit brain tissue, without calcium ion added and it is intended for the determination of the prothrombin time in human blood plasma in accordance with the described methodology. It is kept under nitrogen in sealed glass ampoules. Parameters of the regression line Prothrombin time slope ...... 1.257 ± 0.013 Prothrombin time intercept ...... - 0.242 ± 0.019

Drugs ERM-AC200 Digoxin vial This is a pure material, intended for use in the validation, calibration and monitoring of measurement procedures for digoxin. Analysis of Digoxin is, e.g. done by medical laboratories to alleviate some of the symptoms of heart failure and to help control heart rate and abnormal heart rhythms. The material was characterised using high performance liquid chromatography with UV detection (HPLC-UV), and its structural identity confirmed using nuclear magnetic resonance spectroscopy (NMR). Certified value (mass fraction) ...... 98.0 ± 0.5 %

ERM-AC803 Theophylline 500 mg This is a pure material intended for use in the validation of new methods, and in monitoring the performance of methods commonly used in medical laboratories to determine the level of theophylline in patient samples. Theophylline is a bronchodilator used as a treatment for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). The material was characterised by high performance liquid chromatography with UV detection (HPLC-UV) and its identity was confirmed by gas chromatography – mass spectrometry (GC-MS). Certified value % mass fraction: ...... 99.95 + 0.05% to - 0.08%

Drugs in serum NIST-1599 Anticonvulsant drug level assay standard 4 x 5 mL This material is certified for mass concentrations of two anticonvulsant drugs (valproic acid and carbamazepine) in processed human serum base. It is intended for use in the calibration and standardisation of procedures employed in clinical laboratories for the determination of these drugs in serum. It can also be used for critical evaluation of working or secondary reference solutions prepared either in-house or supplied commercially. This material is supplied as a set of four different freeze-dried preparations, three different mass concentrations and a blank. Analytes low medium high Valproic acid ...... 14.5 0.3 ...... 69.1 4.2 ...... 142.5 4.1 μg/mL Carbamazepine ...... 2.8 0.4 ...... 8.8 0.3 ...... 19.4 0.9 μg/mL

14 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Clinical applications

Code Product Unit NIST-900 Antiepilepsy drug level assay standard 4 x 5 mL This material is certified for mass concentrations of four antiepilepsy drugs (phenytoin, ethosuximide, phenobarbital and primidone) in a processed human serum base. It is intended for use in the calibration and standardisation of procedures employed in clinical laboratories for the determination of these drugs in serum, and for the critical evaluation of working or secondary reference solutions prepared either in-house or supplied commercially. One set contains four bottles with freeze-dried human serum, including a blank (0 μg / mL) and three different concentration levels. Analytes toxic therapeutic sub-therapeutic μg/mL μg/mL μg/mL Phenytonin ...... 60.7 0.9 ...... 16.7 0.3 ...... 4.2 0.1 Ethosuximide ...... 174.7 0.6 ...... 75.9 0.5 ...... 11.8 0.4 Phenobarbital...... 103.6 0.3 ...... 21.6 0.2 ...... 5.3 0.2 Primidone ...... 18.6 0.7 ...... 8.1 0.2 ...... 3.6 0.1 Currently not available

ERM-DA200 Digoxin in human serum vial These reference materials are intended for use in the validation of new methods, and monitoring the performance of methods commonly used in clinical laboratories to determine the digoxin content of human serum samples. They can also be used in the training and evaluation of staff. They are clinically relevant since they closely match the upper and lower decision levels for digoxin monitoring. Digoxin is used clinically in the treatment of heart problems, and has a very narrow range for therapeutic efficacy. The materials are being certified using isotope-dilution liquid chromatography-tandem mass spectrometry (ID- LC/MS-MS). The method uses exact matching isotope dilution LC-MS, in which the serum is spiked with d3-digoxin and then extracted with tert-butyl methyl ether. Liquid chromatography is conducted using a C18 column and a mobile phase of ethanol / water + 0.1% formic acid. An electrospray interface is utilised and is operated in positive ion mode.

Electrolytes NIST-915b Calcium carbonate, clinical 20 g This material is intended for use as an analytical standard of known purity. It is intended primarily for use in the calibration and standardization of procedures for calcium (Ca) determinations employed in clinical analysis and for routine critical evaluation of the daily working standards used in these procedures. The certified values for this material are expressed as % mass fractions. Certified value

CaCO3 ...... 99.907 ± 0.021 % Ca ...... 40.0104 ± 0.0083 %

CO3 ...... 59.923 ± 0.012 %

NIST-924A Lithium carbonate (clinical) 30 g This material is intended primarily for use in the calibrations and standardisation of procedures. It is supplied in crystalline form. Certified purity (mass fraction) ..... 99.867 ± 0.017 %

NIST-929a Magnesium gluconate dihydrate 5 g This material is intended for use as an assay standard for magnesium. The material is highly purified magnesium . gluconate dihydrate [Mg(C6H11O7)2 2H2O] Certified value (mass fraction) Magnesium ...... 5.362 ± 0.027 %

NIST-918B Potassium chloride 30 g This material is intended for use as an analytical standard of known purity. It is intended primarily for use in the calibration and standardization of procedures for potassium (K) and chloride (Cl) determinations employed in clinical analysis and for routine critical evaluation of the daily working standards used in these procedures. The certified values for this material are expressed as % mass fractions Certified value KCl ...... 99.927 ± 0.014 % K ...... 52.4121 ± 0.0086 % Cl ...... 47.5284 ± 0.0049 %

NIST-919B Sodium chloride 30 g This material is intended for the production of saline solutions of accurately known concentration and the calibration of instrumentation and standardization of procedures used in the determination of sodium and chloride ions in clinical analysis. A unit consists of a single glass bottle containing 30 g of the material. The certified values are expressed as % mass fractions. Certified value NaCl ...... 99.835 ± 0.020 % Cl ...... 60.564 ± 0.014 % Na ...... 39.2747 ± 0.0075 %

Electrolytes in serum BCR-304 Calcium (II), Magnesium (II) and Lithium (I) in human serum vial Each sample is in lyophilised form equivalent to about 5.3 mL of human serum kept under vacuum in rubber stoppered vials. Amount-of-substance concentration in the reconstituted material Analytes Ca ...... 2.201 ± 0.019 mmol/L Mg ...... 1.85 ± 0.03 mmol/L Li ...... 0.985 ± 0.029 mmol/L

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Clinical applications

Code Product Unit NIST-956C Electrolytes in frozen human serum set (6) This material is primarily intended for use in the calibration and validation of procedures and methods employed in clinical analysis for the determination of electrolytes in either diluted or undiluted human serum or plasma. It can be used for calibrating direct-reading ion-selective electrode analyzers [1] and for validating secondary reference materials. A unit consists of six sealed ampoules of frozen human serum, two ampoules each of three different concentration levels. Each ampoule contains approximately 2.0 mL of human serum. Certified values for elements at three levels. Analytes level 1 level 2 level 3 Ca ...... 2.981 0.022 ...... 2.538 0.016...... 2.095 0.013 mmol/L Cl ...... 104.9 3.2 ...... 121.5 2.5...... 137.4 1.8 mmol/L Li ...... 1.606 0.024 ...... 1.068 0.016...... 0.457 0.007 mmol/L Mg ...... 1.247 0.013 ...... 0.857 0.010...... 0.470 0.005 mmol/L K ...... 5.976 0.051 ...... 3.977 0.034...... 1.982 0.017 mmol/L Na ...... 118.8 1.0 ...... 137.5 1.6...... 157.4 1.4 mmol/L

NIST-909C Human serum 6 x 10 mL This material is intended primarily for use in validating analytical methods for the determination of specified constituents in human serum. This SRM can also be used for quality assurance when assigning values to in- house control materials. A unit consists of three bottles, each containing 2 mL. Analytes value mmol/L value mg/dL Cholesterol ...... 3.703 0 081 ...... 143.2 3.1 Creatinine...... 0.07289 0.00161 ...... 0.8245 0.0182 Glucose ...... 5.050 0 059 ...... 90.98 1.07 Total glycerides ...... 1.214 0.017 ...... 107.5 1.5 (b) Urea ...... 4.321 0.089 ...... 25.95 0.53 Uric acid ...... 0.278 0.006 ...... 4.68 0.10 Analyte μmol/L ng/mL Selenium 1.503 ± 0.035 118.7 ± 3.3 (b) Results in mg/dL are expressed as the equivalent concentration of triolein

This product is not a direct replacement for NIST-909B

HEC JCCRM111 Sodium, potassium and chloride in frozen human serum set (3) This material is primarily intended for evaluating the accuracy of serum (plasma) Na, K and Cl measurements with (direct and indirect) ion selective electrodes (ISE) in clinical laboratory tests. It can also be used to assess the accuracy of serum Na, K measurements by flame spectrometry and serum Cl measurements by routine coulometric titration. A unit of the material consists of 3 vials, each containing 1,5 ml serum at different levels of the components. Certified values (amount of substance concentration) in mmol/l. Certified concentrations and uncertainties Na K Cl High level JCCRM 111-6H ...... 157.2 ± 0.4 ...... 5.662 ± 0.018 ...... 120.8 ± 0.4 mmol/L Medium level JCCRM 111-6M ...... 141.3 ± 0.4 ...... 4.473 ± 0.017 ...... 106.4 ± 0.3 mmol/L Low level JCCRM 111-6L ...... 123.9 ± 0.3 ...... 3.246 ± 0.010 ...... 89.8 ± 0.2 mmol/L

Enzymes BCR-647 Adenosine deaminase (ADA 1), human 1 mL The intended use of the material is to validate, to calibrate or to assess the performance of adenosine deaminase catalytic concentration measurement procedures. The user must confirm that the transfer procedure is satisfactory. Each sample is in lyophilised form and equivalent to about 1 mL of solution of purified adenosine deaminase (ADA 1) from human erythrocytes. The preparation has been stabilised by incorporation in a matrix of 50 mmol/L Tris/HCl buffer pH = 7.4 and human serum albumin 30 g/L. No contamination, as assessed by measurement of their catalytic activity, has been detected for the following enzymes : acid phosphatase, acetylcholinesterase, glutamate dehydrogenase, glucose-6-phosphate dehydrogenase and adenosine deaminase isoenzyme 2. L-lactate dehydrogenase, alanine aminotransferase and aspartate aminotransferase were found in trace amounts 0.39 %, 0.01 % and 0.09 %, respectively (% of total adenosine deaminase catalytic activity). Catalytic concentration ...... 2.55 0.09 μkat/L

ERM-AD454 Alanine aminotransferase Amp. Each sample is in lyophilised form and equivalent to about 1 mL of a solution of purified alanine aminotransferase from pig heart. The material is kept under dry nitrogen in sealed glass ampoules. Catalytic concentration of alanine aminotransferase in reconstituted material as determined by the IFCC method at 37 °C Analyte Alanine aminotransferase ...... 186 ± 4 U/L ...... 3.09 ± 0.07 μkat/L

IRMM/IFCC 456 alpha-Amylase Amp. Each sample is in lyophilised form and equivalent to about 1 mL of a solution of a partially purified human pancreatic -amylase. The material is kept under nitrogen gas in sealed glass ampoules. Catalytic concentration of -amylase in reconstituted material as determined by the IFCC method at 37 °C Analyte -Amylase ...... 546 ± 19 U/L ...... 9.1± 0.3 μkat/L

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Clinical applications

Code Product Unit ERM-AD457/IFCC Aspartate transaminase (AST) vial This material is primarily intended to be used to control the performance of the IFCC reference procedure for the determination of AST at 37 °C. The material is a lyophilised powder from 1.0 mL of recombinant AST from E. coli in a pH 7.5 buffer, supplied in a glass vial. The certified values were assigned using the IFCC reference procedure for the measurement of catalytic activity concentrations of enzymes at 37 °C. When the material is used as a calibrant in a particular measurement procedure the commutability should be verified for the assay concerned. AST ...... 104.6 ± 2.7 U/l ...... 1.74 ± 0.05 kat/l BCR-299 Creatine kinase (CK-BB Isoenzyme) Amp. from human placenta Catalytic concentration (IFCC recommended method) of creatine kinase in reconstituted material U/l ...... 325 10 μkat/l ...... 5.42 0.17 Each sample is in lyophilised form and equivalent to about 1 mL of solution of partially purified creatine kinase (CK-BB) from human placenta. The preparation has been stabilised by incorporation in a matrix of bovine serum albumin. The material is kept under nitrogen gas in rubber stoppered vials. ERM-AD455 Creatine kinase (CK-MB Isoenzyme) vial Each sample is in lyophilised form and equivalent to about 1 mL of a solution of purified creatine kinase from human heart. Material is kept under dry nitrogen gas in sealed glass ampoules. Catalytic concentration of creatine kinase-2 (CK-MB) in reconstituted material as determined by the IFCC method at 37 °C Analyte Creatine kinase-2 (CK-MB) ...... 101± 4 U/L ...... 1.68 ± 0.07 μkat/L ERM-AD452 gamma-Glutamyltransferase Amp. Each sample is in lyophilised form and equivalent to about 1 mL of a solution of a partially purified pig kidney -glutamyltransferase. The material is kept under nitrogen gas in sealed glass ampoules. Catalytic concentration of -glutamyltransferase in reconstituted material as determined by the IFCC method at 37 °C. Analyte -Glutamyltransferase ...... 114.1 ± 2.4 U/L ...... 1.90 ± 0.04 μkat/L ERM-AD453 Lactate dehydrogenase isoenzyme 1 Amp. Each sample is in lyophilised form and equivalent to about 1 mL of a solution of purified lactate dehydrogenase from human erythrocytes. The material is kept under dry nitrogen in sealed glass ampoules. Catalytic concentration of lactate dehydrogenase isoenzyme 1 in reconstituted material as determined by the IFCC method at 37 °C. Analyte Lactate dehydrogenase isoenzyme 1 .....502 ± 7U/L ...... 8.37 ± 0.12 μkat/L BCR-693 Lipase (human pancreatic lipase from pancreatic juice) Amp. Each sample is in lyophilised form and equivalent to about 1 mL of solution of purified human pancreatic lipase from human pancreatic juice. The preparation has been stabilised by incorporation in a matrix of Tris 20 mmol/L, pH = 7.6 and BSA 40 g/L. No contamination, as assessed by measurement of their catalytic activity, has been detected for the following enzymes: ALP, ALT, -Amylase, AST, esterase, GGT and LDH. The material is kept under dry nitrogen in neutral clear glass ampoules. Catalytic concentration ...... 28.9 1.2 μkat /L BCR-694 Lipase (human recombinant pancreatic lipase) Amp. Each sample is in lyophilised form and equivalent to about 1 ml of solution of purified recombinant pancreatic lipase from V79-rHPL cell line. The preparation has been stabilised by incorporation in a matrix of Tris 20 mmol/L, pH = 7.6 and BSA 40 g/L. No contamination, as assessed by measurement of their catalytic activity, has been detected for the following enzymes: ALP, ALT, -Amylase, AST, esterase, GGT and LDH. The material is kept under dry nitrogen in neutral clear glass ampoules. Certified value Catalytic concentration ...... 17.4 1.0 μkat/L BCR-410 Prostatic acid phosphatase Amp. from human prostate Each sample is in lyophilised form and equivalent to about 1 mL of a solution of enzyme, stabilised by incorporation in a matrix of human serum albumin. Material is kept under dry nitrogen in sealed glass ampoules. Catalytic concentration of prostatic acid phosphatase in reconstituted material. Analyte Prostatic acid phosphatase ...... 28 ± 0.7 U/L ...... 0.466 ± 0.012 nkat/L Enzymes in serum HEC JCERM20327 Lactate dehydrogenase (LDH) in bovine serum albumine unit (Enzyme ST,ALT,CK,ALP,LD,gamma-GT,AMY Human recombinant enzymes) Lot No. 003 certified value (catalytic concentration)...... 398 ± 5 U/l

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Clinical applications

Code Product Unit Metabolites and substrates NIST-927D Bovine serum albumin (7% solution) 10 x 2.1 mL This material is intended primarily for use in the standardization of procedures employed in clinical analyses for total serum protein, for critical evaluation of daily working standards used in these procedures, and as a reference standard for assays of total protein by colorimetric methods. It is a solution (mass fraction 7 %) of known protein concentration and purity. The protein content of this material was determined using the biuret reference method that is recommended for use in standardizing laboratory-prepared protein solutions and "normal" serum pools. In addition to the measurement using the biuret method, NIST made measurements of the bovine serum albumine (BSA) concentration using amino acid analysis. A unit consists of 10 ampoules each containing 2.1 mL of solution. Certified bovine serum albumine concentration by amino acid analysis BSA concentration ...... 65.41 g/L ± 0.82 g/L Reference total protein concentration by the biuret method Protein concentration ...... 70.10 g/L ± 0.74 g/L

NIST-2389A Amino acids in 0.1 mol/L hydrochloric acid 5 x 1.2 mL This material is a solution of 17 amino acids in a 0.1 mol/L aqueous solution of hydrochloric acid. It is intended primarily for the use in calibration of chromatographic instrumentation for the determination of amino acids. A unit of consists of five 2 mL ampoules each containing approximately 1.2 mL of the solution. Amino acid concentration mmol/L Amino acid concentration mmol/L Alanine ...... 2.50 ± 0.07 Lysine ...... 2.41 ± 0.17 Arginine ...... 2.51 ± 0.07 Methionine ...... 2.51 ± 0.07 Aspartic acid ...... 2.50 ± 0.08 Phenylalanine ...... 2.55 ± 0.09 Cystine ...... 1.23 ± 0.06 Proline ...... 2.46 ± 0.11 Glutamic acid ...... 2.50 ± 0.08 Serine ...... 2.44 ± 0.11 Glycine ...... 2.52 ± 0.07 Threonine ...... 2.49 ± 0.07 Histidine ...... 2.52 ± 0.07 Tyrosine ...... 2.54 ± 0.08 Isoleucine ...... 2.44 ± 0.11 Valine ...... 2.51 ± 0.10 Leucine ...... 2.44 ± 0.11

NIST-916A Bilirubin 100 mg This material consists of a sample of unconjugated bilirubin that is certified as a chemical of known purity. It is intended primarily for use in the calibration and standardization of procedures used for the determination of bilirubin in clinical samples and for routine evaluations of daily working standards used in these procedures. This material can also be used for quality assurance when assigning values to in-house control materials.

Certified value (mass fraction) ...... 98.3 ± 0.3 %

NIST-911C Cholesterol 2 g This material is intended primarily for use in the calibration and standardization of procedures for the determination of cholesterol in clinical samples and for routine evaluations of daily working standards used in these procedures. A unit consists of 2 g of material. Certified purity (mass fraction)...... 99.2 ± 0.4 %

NCS ZC76020B Cholesterol (formerly GBW09203b) 300 mg Certified purity ...... 99.7 0.1 %

NMIJ CRM6001-9 Cholesterol 1 g This material is intended for the use in calibration of analytical instruments and validation of analytical techniques and instruments. Each unit contains 1 g of high purity cholesterol filled in amber borosilicate glass vials and an aluminized bag with argon gas.

Certified purity (mass fraction)...... 99.9 0.1 %

NIST-RM 8444 Cotinine in human urine 4 x 5 mL This standard is intended primarily for use in validating methods for the determination of cotinine in human urine. One set consists of four vials, each containing cotinine in 5 ml human urine, which has been freeze dried. Two vials are “blank” concentration levels, typical for non-smokers without exposure to cigarette smoke, one vial is a “low” concentration level corresponding to non-smokers with passive exposure to side-stream smoke, and one vial is a “high” level, typical of smokers. Analyte blank low high ng/mL ng/mL ng/mL Cotinine ...... 0.8 ...... 54...... 488

NIST-914A Creatinine 10 g This material is intended primarily for use in the calibration and standardisation of procedures used for determination of creatinine. Certified purity (mass fraction)...... 99.7 ± 0.3 %

ME 70002 Ethyl-beta-D-6-glucuronide 2 mg ME 70010 Ethyl-beta-D-6-glucuronide 10 mg ME 70502 Ethyl-beta-D-6-glucuronide-D5 2 mg ME 70510 Ethyl-beta-D-6-glucuronide-D5 10 mg NIST-917C D-Glucose (dextrose, clinical) 50 g

NIST-925 4-Hydroxy-3-methoxy-DL-mandelic acid (VMA), clinical 1 g This material is intended primarily for use in the calibration and standardisation of procedures employed in clinical analysis and for routine critical evaluation of the daily working standards used in these procedures. Certified purity (mass fraction)...... 99.4 0.4 %

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Clinical applications

Code Product Unit NIST-1595 Tripalmitin 2 g This material is intended primarily for use in the calibration and standardisation of procedures for the chemical analysis of serum for triglycerides, and for the critical evaluation of routine working or secondary reference materials used in these procedures. Certified purity (mass fraction) ...... 99.5 ± 0.2 %

NIST-912A Urea 25 g This material is certified as a chemical of known purity. It is intended primarily for use in the calibration and validation of procedures for uric acid determinations employed in clinical analysis. Certified purity (mass fraction) ...... 99.9 ± 0.1 % Moisture ...... 0.02 ± 0.003 % Biuret...... 0.02 ± 0.02 % Ash ...... 0.001 ± 0.0007 % Insoluble matter ...... 0.0001 ± 0.00005 %

NCS ZC76009 Urea (formerly GBW09201) 6 g This material is a high-purity material intended for use as a primary calibrator for higher order reference measurement procedures. Certified purity...... 99.9 ± 0.2 %

NIST-913A Uric acid 10 g This material is certified as a chemical of known purity. It is intended primarily for use in the calibration and standardization of procedures for uric acid determinations employed in clinical analysis and for routine critical evaluation of the daily working standards used in these procedures. Certified purity (mass fraction) ...... 99.6 ± 0.1%

Metabolites and substrates in serum NIST-1952A Cholesterol in human serum set (6) This material is intended for use in evaluating the accuracy of clinical procedures for the determination of cholesterol in serum, in calibrating instruments and equipment used in these procedures and in validating working or secondary standards. It consists of six vials of freeze-dried serum, two each of three different cholesterol levels. Concentrations are also given in mg/dL/g. Analyte low medium high Cholesterol (mmol·L-1·g-1) ...... 13.89 ...... 21.29 ...... 28.91

HEC JCCRM211 Cholesterol in human serum unit This material is intended for use in evaluating the accuracy of total cholesterol assays in clinical laboratory testing and validating secondary or working reference materials. The material was prepared according to an NCCLS protocol to ensure that, while avoiding lipoprotein degradation, its properties would be the same as those of fresh serum. A single set of JCCRM 211-1 consists of four vials, two for each of the concentration levels (medium and high), each containing 0.5 ml of frozen human serum. Certified value JCCRM 211-1M ...... 5.308 0.020 mmol/L JCCRM 211-1M ...... 6.786 0.026 mmol/L

NIST-968D Fat soluble cholesterol and vitamins in human serum set (2) This material is intended for use in validating methods for determining fat-soluble vitamins, carotenoids, and cholesterol in human serum and plasma. It can also be used for quality assurance when assigning values to in- house control materials for these constituents. A unit of the material consists of two vials of frozen human serum at a single concentration level. Certified values (mass concentrations): Analyte μg/ml Total Retinol ...... 0.311 ± 0.050 -Tocopherol ...... 1.39 ± 0.12 -Tocopherol ...... 5.93 ± 0.55 Total -Carotene ...... 0.078 ± 0.007 Cholesterol ...... 1335 ± 4

NIST-967A Creatinine in Frozen Human Serum set (4) This material is intended primarily for use in evaluating the accuracy of procedures for the determination of creatinine in human serum and also for use in validating working or secondary reference materials. A unit consists of four stoppered ampoules of frozen human serum, two ampoules each at two different creatinine concentration levels. One level corresponds to the normal range of serum creatinine levels, and the second level is intended to correspond to levels found in chronic kidney desease. Each ampoule contains 1.0 mL of human serum. Concentrations Level I ...... 0.0749 ± 0.0016 mmol/L Level II ...... 0.3427 ± 0.0072 mmol/L

ERM-DA250 Frozen human serum 1.0 mL (Creatinine and electrolytes in frozen human serum - high level) The material is intended for use in the validation and ongoing monitoring of methods of analysis for the determination of creatinine and electrolytes in human blood samples. Each unit consists of 1 ml of human serum in a screw-cap plastic vial. Constituents certified value Constituents certified value Constituents certified value Creatinine ...... 39 ± 3 mg/kg Lithium ...... 6.6 ± 0.4 mg/kg Potassium ...... 277 ± 14 mg/kg Calcium ...... 123 ± 5 mg/kg Magnesium ...... 47 ± 3 mg/kg Sodium ...... 3370 ± 110 mg/kg

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Clinical applications

Code Product Unit ERM-DA251 Frozen human serum (low) 1.0 mL (Creatinine and electrolytes in frozen human serum - low level) The material is intended for use in the validation and ongoing monitoring of methods of analysis for the determination of creatinine and electrolytes in human blood samples. Each unit consists of 1 ml of human serum in a screw-cap plastic vial. Constituents certified value Constituents certified value Creatinine...... 22 2 mg/kg Magnesium...... 19 ± 2 mg/kg Calcium ...... 71 ± 3 mg/kg Potassium ...... 136 ± 7 mg/kg Lithium ...... 4.5 ± 0.3 mg/kg Sodium ...... 2740 ± 80 mg/kg

ERM-DA252 Creatinine in frozen human serum 1.0 mL (low level) The material is intended for use in the validation and ongoing monitoring of methods of analysis for the determination of creatinine in human blood samples. Each unit consists of 1 ml of human serum in a screw-cap plastic vial. Certified value (mass concentration) ...... 3.1 ± 0.5 mg/kg

ERM-DA253 Creatinine in frozen human serum 1.0 mL (high level) The material is intended for use in the validation and ongoing monitoring of methods of analysis for the determination of creatinine in human blood samples. Each unit consists of 1 ml of human serum in a screw-cap plastic vial. Certified value (mass concentration) ...... 50 ± 2 mg/kg

BCR-573 Creatinine in human serum (low) 0.9 g Each sample is the lyophilised form of approximately 1 mL portion of serum, with no additives. The mass of the lyophilised material contained in the ampoule is about 0.09 g. Amount-of-substance concentration ...... 68.7 ± 1.4 μmol/L

BCR-574 Creatinine in human serum (medium) 0.9 g Each sample is the lyophilised form of approximately 1 mL portion of serum, spiked with no further additives. The mass of the lyophilised material contained in the ampoule is about 0.09 g. Amount-of-substance concentration ...... 105.0 ± 1.3 μmol/L

BCR-575 Creatinine in human serum (high) 0.9 g Each sample is the lyophilised form of approximately 1 mL portion of serum spiked with exogenous creatine, with no further additives. The mass of the lyophilised material contained in the ampoule is about 0.09 g. Amount-of-substance concentration ...... 404.1 ± 7.1μmol/L

BCR-573I Set of creatinine interfering substances 3 vials The set consists of three vials with lyophilised solutions. - 0.025 mg calcium dobesilate / 1.2 cefoxitin - 0.044 mg sodium pyruvate - 0.108 mg bilirubin ditaurate Please note: The material consists of lyophilised preparations of three substances known to interfere with routine creatinine methods. For further information, see certification report for Material BCR-573.

ME 41058 Ethylglucuronide, human serum control with reference values 10 x 2.5 mL (Medidrug ETG 2/09-A S-plus) Lyophilised serum control prepared from human serum for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in serum. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 0.840 mg/L Ethyl sulfate ...... 0.970 mg/L

AC-SE015.010.001 Ethylglucuronide in serum ETG 3/10-A SE, lyophilised 10 x 2.5 mL for in vitro diagnostic use Analytes Target value Ethylglucuronide ...... 0,64 mg/L Ethylsulfate ...... 0,91mg/L

NIST-965B Glucose in frozen human serum set (8) This material is intended primarily for determination of glucose in human serum. It is also intended for use in validating working or secondary reference materials. A unit of NIST-965a consists of eight flame sealed ampoules of frozen human serum, two ampoules at each of four different concentration levels. Each ampoule contains 2.00 ± 0.04 mL of human serum. Concentration levels mmol/L Level 1 ...... 1.836 0.027 Level 2 ...... 4.194 0.059 Level 3 ...... 6.575 0.094 Level 4 ...... 16.35 0.20

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Clinical applications

Code Product Unit HEC JCCRM521 Glucose, Creatinine, Uric Acid and Urea-N in human serum unit (abnormally high), H, M, each 2 vials, 1ml) This certified reference material is primarily intended for evaluating the accuracy of routine methods and validating working reference materials. The material consists of 6 plastic vials (two for each of three levels), each containing 1ml serum. Certified mass concentrations (mg/dl): Level 1 Level 2 Level 3 Uric acid ...... 5.54 ± 0.04 ...... 8.78 ± 0.06 ...... 12.04 ± 0.08 Creatinine ...... 0.89 ± 0.02 ...... 2.28 ± 0.05 ...... 5.14 ± 0.11 Glucose ...... 93.4 ± 0.9 ...... 152.1 ± 1.4 ...... 248.0 ± 2.2 Urea-N ...... 13.0 ± 0.4 ...... 27.0 ± 0.7 ...... 46.0 ± 1.1

NIST-1955 Homocysteine and folate in frozen human serum unit (3) This material is intended primarily for use in evaluating the accuracy of clinical procedures for the determination of homocysteine and folate (in various forms) in human serum. It is also intended for use in validating working or secondary reference materials. A unit consists of three bottles of frozen human serum, each of three concentration levels. Each bottle contains 1 mL of human serum. Certified values (amount-of-substance concentration and mass concentration): Concentration levels for Homocysteine ...... μmol/L ...... μg/mL Level I ...... 3.98 ± 0.18 ...... 0.538 ± 0.024 Level II ...... 8.85 ± 0.60 ...... 1.196 ± 0.082 Level III ...... 17.7 ± 1.1 ...... 2.39 ± 0.15 Concentration levels for 5-Methyltetrahydrofolic acid ...... nmol/L ...... ng/mL Level I ...... 4.26 ± 0.25 ...... 1.96 ± 0.12 Level II ...... 9.73 ± 0.24 ...... 4.47 ± 0.11 Level III ...... 37.1 ± 1.4 ...... 17.03 ± 0.64 a

NIST-1951B Lipids in frozen human serum 4 x 1 mL This material is intended primarily for use in evaluating the accuracy of clinical procedures for the determination of total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides (both total glyceride species and triglycerides only) in human serum. It is also intended for use in validating working or secondary reference materials. A unit consists of four bottles of frozen human serum, two bottles each of two different analyte concentration levels. Each bottle contains 1 mL of human serum. Concentrations are also given in mg/dL. Analyte level I level II Total cholesterol ...... 4.804 0.014 ...... 6.895 0.022 mmol/L Total glycerides ...... 1.370 0.015 ...... 2.988 0.036 mmol/L Triglycerides only ...... 1.208 0.013 ...... 2.700 0.027mmol/L

CEN DMR-263A Metabolites and substrates in frozen human serum (creatinine, cholesterol, glucose, urea, unit uric acid) This material is intended for the calibration and validation of clinical procedures, and for preparation of secondary reference materials. It can also be used in calibration and validation of glucose procedures based on high performance liquid chromatography with refraction index and electrochemical detection. Each unit consists of one cryogenic vial of 1 mL serum.

Certified values Glucose ...... 82.9 mg/dL Cholesterol ...... 159.73 mg/dL Creatinine ...... 0.7512 mg/dL Uric acid ...... 5.21 mg/dL Urea ...... 27.07 mg/dL

SERO100205 Seronorm Lipid 12 x 3 mL (serum control for clinical chemistry) Animal assayed serum for the accuray control of lipid analyses. It is a stable freeze-dried all animal control serum providing analytical data for major lipid components. Each batch is supplied with a data key providing reference and analytical values for each component. The component levels are on the borderline between normal and pathological range. The analytical data are elaborated in collaboration with independent laboratories using reference or well accepted methods. The components are: - Bile acids - Cholesterol, total - HDL-cholesterol - LDL-cholesterol - Phospholipids - Triglycerides - Fatty acid composition of phospholipids and total lipids (palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, dihomogammalinol acid, arachidonic acid, timnodonic acid, docosapentaenoic acid, docosahexaenoic acid, phytanic acid).

HEC JCCRM223 Triglycerides in human serum unit Certified values (amount-of-substance concentration) in the range 1.04 mmol/l to 2.64 mmol/l with corresponding uncertainties of 0.03 to 0.07 mmol/l. HEC JCCLS021 Uric acid in frozen human serum set (6) This material for is primarily intended for evaluating reference methods for determining uric acid in human serum, and in validating secondary reference materials. Each material consists of a set of six vials (two vials for each of 3 levels) with one ml of serum. Certified concentrations: Medium concentration High concentration Abnormally high concentration 4.342 0.010 mg/dl ...... 7.496 0.017 mg/dl ...... 10.71 0.03 mg/dl 0.2583 0.0006 mmol/l ...... 0.4460 0.0010 mmol/l ...... 0.6374 0.0014 mmol/l

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Clinical applications

Code Product Unit Metabolites and substrates in urine ME 41079 Ethylglucuronide, human urine control with reference values 10 x 2.5 mL (Medidrug ETG 1/08-B U-plus) Lyophilised serum control prepared from human urine for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in urine. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 0.350 mg/L

ME 41081 Ethylglucuronide, human urine control with reference values 10 x 2.5 mL (Medidrug ETG 1/10-B U-plus) Lyophilised serum control prepared from human urine for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in urine. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 0.878 mg/L Ethyl sulfate ...... 0.920 mg/L

AC-UR015.010.001 Ethylglucuronide in urine ETG 3/10-B UR, lyophilised 10 x 2.5 mL for in vitro diagnostic use Analytes Target value Ethylglucuronide ...... 1,27 mg/L Ethylsulfate ...... 0,81mg/L

Non-electrolyte metals in serum LGC7330 Selenomethionine enriched with 76Se 10 mg Assessed value 76Se Isotopic abundance ... 99.8 +0.2 / -3.1 % (m/m)

Non-electrolyte metals NIST-937 Iron metal (clinical) 50 g This material is intended for use as an assay standard for iron. It is provided in the form of chips sized between 0.5 mm and 1.8 mm mesh. Certified purity (mass fraction)...... 99.90 ± 0.02 %

NIST-928 Lead nitrate (clinical) 30 g This material is certified for use as an assay standard for lead. Certified purity (mass fraction)...... 100.00 ± 0.03 %

Non-electrolyte metals in blood NIST-955C Lead in caprine blood 4 x 2 mL This material is intended primarily for use in evaluating the accuracy of lead concentration determinations in blood and for use in validating working or secondary reference materials for lead in blood analysis. This material replaced NIST-966. A unit consists of four vials of frozen caprine blood at four concentration levels: a base level and three progressively elevated levels that contain endogenous lead and spiked inorganic arsenic, cadmium, inorganic mercury, methylmercury, and ethylmercury. Certified values are provided for lead. Each vial contains approximately 2 mL of whole blood. Certified concentration Lead (μg/dL) Lead (μmol/L) Level 1 ...... 0.424 ± 0.011 ...... 0.02047 ± 0.00053 Level 2 ...... 13.950 ± 0.080 ...... 0.6733 ± 0.0038 Level 3 ...... 27.76 ± 0.16 ...... 1.3400 ± 0.0076 Level 4 ...... 45.53 ± 0.27 ...... 2.198 ± 0.013 The certificate is being updated to reflect additional concentration values for arsenic, cadmium, mercury (total), ethylmercury, inorganic mercury, and methylmercury.

ERM-CE195 Lead and cadmium in bovine blood, medium level Amp. Each sample is in lyophilised form equivalent to about 5.75 mL of bovine blood with additives, kept under nitrogen in rubber stoppered vials. Mass concentration in the reconstituted material Analytes Pb ...... 416 ± 9 μg/L Cd ...... 5.06 ± 0.15 μg/L

ERM-CE196 Lead and cadmium in bovine blood, high level Amp. Each sample is in lyophilised form equivalent to about 5.75 mL of bovine blood with additives, kept under nitrogen in rubber stoppered vials. Mass concentration in the reconstituted material Analytes Pb ...... 772 ± 11 μg/L Cd ...... 12.33 ± 0.20 μg/L

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Clinical applications

Code Product Unit BCR-634 Lead and cadmium in reconstituted human blood (low) vial The material is supplied in lyophilised form in brown glass vials. Sodium-EDTA was used as anticoagulant. No other preservatives were added. The content of a vial is approximately 0.6 g dry matter with residual moisture content less than 2 % and equivalent to 3.0 mL of fresh whole blood. This material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV-1&2, Anti-HCV and Anti-HTLV-I&II. However, as all biological material of human origin the blood should be treated as contagious material. Analytes mass concentration Cd ...... 1.4 0.4 μg/L Pb ...... 46 5 μg/L

BCR-635 Lead and cadmium in reconstituted human blood (medium) vial The material is supplied in lyophilised form in brown glass vials. Sodium-EDTA was used as anticoagulant. No other preservatives were added. The content of a vial is approximately 0.6 g dry matter with residual moisture content less than 2 % and equivalent to 3.0 mL of fresh whole blood. This material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV-1&2, Anti-HCV and Anti-HTLV-I&II. However, as all biological material of human origin the blood should be treated as contagious material. Analytes mass concentration Cd ...... 6.6 0.6 μg/L Pb ...... 210 24 μg/L

BCR-636 Lead and cadmium in reconstituted human blood (high) vial The material is supplied in lyophilised form in brown glass vials. Sodium-EDTA was used as anticoagulant. No other preservatives were added. The content of a vial is approximately 0.6 g dry matter with residual moisture content less than 2 % and equivalent to 3.0 mL of fresh whole blood. This material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV-1&2, Anti-HCV and Anti-HTLV-I&II. However, as all biological material of human origin the blood should be treated as contagious material. Analytes mass concentration Cd ...... 11.6 0.6 μg/L Pb ...... (0.52 0.05) 103 μg/L

Non-electrolyte metals in urine NIST-2672A Mercury in urine set (4) This material is intended primarily for use as an analytical standard for the determination of mercury in urine. It consists of four bottles of freeze-dried urine containing mercury, two bottles each at low and elevated levels. Certified values after reconstitution low level elevated level Hg ...... (0.002) ...... 0.105 mg/L

NIST-2670A Toxic elements in freeze dried urine 4 x 20 mL This material is primarily intended for use in evaluating the accuracy of clinical methods and for the calibration of apparatus used to determine the concentration of toxic metals and other elements in human urine or similar matrices. It can also be used to validate working or secondary reference materials. It consists of four bottles of freeze-dried urine, two bottles each at the low and high levels.The low level urine was prepared from human urine that was lyophilised after pooling and centrifugation. The high level urine was prepared by spiking an aliquot of the pooled and homogenized low-level urine with selected metals, followed by lyophilisation. Due to the centrifugation (which improved sample homogeneity), neither level represents a fresh urine pool from a normal human population.

Analytes low elevated level Antimony ...... 0.971 0.033 ...... 0.824 0.070 μg/L Cadmium ...... 0.0591 0.0034 ...... 4.862 0.084 μg/L Cesium ...... 1.075 0.031 ...... 1.085 0.052 μg/L Cobalt ...... 0.166 0.040 ...... 51.2 3.2 μg/L Iodine ...... 88.2 1.1 ...... 88.2 1.1 μg/L Lead ...... 0.49 0.16 ...... 233.2 9.4 μg/L Mercury ...... 0.0663 0.0058 ...... 95.1 0.98 μg/L Manganese ...... 99 12 μg/L Molybdenum ...... 114.1 4.8 μg/L Platinum ...... 51.5 6.6 μg/L Selenium ...... 229.5 8.3 μg/L Thallium ...... 0.0162 0.0045 ...... 5.417 0.064 μg/L Thorium ...... 0.0053 0.0014 ...... 0.01606 0.00077 μg/L Uranium ...... 0.1020 0.0023 ...... 4.997 0.071 μg/L Currently not available

Non-peptide hormones NIST-921 Cortisol (hydrocortisone) 1 g This material is intended primarily for use in the calibration and standardisation of procedures for cortisol determinations employed in clinical analysis and for routine evaluation of the daily working standards used in these procedures. Certified value (mass fraction): Analyte Cortisol (hydrocortisone) ...... 98.9 ± 0.2 %

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Clinical applications

Code Product Unit IRMM-468 Thyroxine (T4) vial The material can be used as a calibrant by manufacturers and laboratories, e.g. for the preparation of lower order reference materials and for validation studies. It consists of an off-white cristalline powder in an amber glass vial sealed under N2 atmosphere. Each vial contains about 100 mg of the powder. Certified value (mass fraction) ...... 98.6 ± 0.7 %

IRMM-469 3,3',5 Triiodothyronine (T3) vial The material can be used as a calibrant by manufacturers and laboratories, e.g. for the preparation of lower order reference materials and for validation studies. It consists of an off-white cristalline powder in an amber glass vial sealed under N2 atmosphere. Each vial contains about 100 mg of the powder. Certified value (mass fraction) ...... 91.1 ± 0.7 %

Non-peptide hormones in serum ERM-DA192 Cortisol in human serum (unspiked) Amp. Each sample is the lyophilised form of a 1.25 mL portion of serum without additives kept under nitrogen in sealed glass ampoules. Cortisol concentration in the reconstituted material μg/L ...... 98.8 ± 2.0 nmol/L ...... 273 ± 6

ERM-DA193 Cortisol in human serum (spiked) Amp. Each sample is the lyophilised form of a 1.25 mL portion of serum without additives kept under nitrogen in sealed glass ampoules. Cortisol concentration in the reconstituted material μg/L ...... 277 ± 5 nmol/L ...... 763 ± 14

ERM-DA451 Cortisol reference serum panel of fresh frozen human sera 34 vials The panel is primarily intended for use in evaluation/verification of in vitro test systems for serum cortisol by method comparison with the ID-GC/MS method (for an appropriate measurement protocol, see full report). The results shall be described by linear regression/bias plot and interpreted in terms of sensitivity, specificity and metrologically correct measurement (trueness). The method comparison will also be used to investigate the suitability of the panel for recalibration of a test system. IRMM/IFCC-451 is a reference serum panel consisting of 34 vials originating from native single-donations that does not contain any additives. It is available in the form of screw capped cryo-vials (34 x 1 mL serum).

BCR-576 Estradiol-17-beta in human serum (low level) Amp. Each sample is the lyophilised form of a 5 mL portion of serum without additives kept under nitrogen in sealed glass ampoules. Amount-of-substance concentration in the reconstituted material ...... 0.114 ± 0.005 nmol/L

BCR-577 Estradiol-17-beta in human serum (medium level) Amp. Each sample is the lyophilised form of a 1 mL portion of serum without additives kept under nitrogen in sealed glass ampoules. Amount-of-substance concentration in the reconstituted material ...... 0.689 ± 0.032 nmol/L

BCR-578 Estradiol-17-beta in human serum (high level) Amp. Each sample is the lyophilised form of a 1 mL portion of serum without additives kept under nitrogen in sealed glass ampoules. Amount-of-substance concentration in the reconstituted material ...... 1.34 ± 0.07 nmol/L

ERM-DA347 Progesterone in human serum (low) Amp. Each sample is the lyophilised form of a 1 mL portion of serum, containing endogenous progesterone, without additives kept under nitrogen gas in sealed glass ampoules. Progesterone concentration in the reconstituted material: ...... 3.19 ± 0.07 ng/L ...... 10.13 ± 0.21 nmol/L

BCR-348R Progesterone in human serum (high) Amp. This material is intended to be used for trueness assessment and quality control of progesterone measurement procedures using ID-GC-MS and to verify the comparability of results from different laboratories using that technique. It can also be used for calibration or quality control of in vitro diagnostic devices if commutability of this material has been demonstrated using ID-GC-MS reference method for comparison. It consists of 1 mL of human serum lyophilised in an ampoule which is sealed under N2 atmosphere. Each ampoule contains about 80 mg of the lyophilised powder. Mass concentration:...... 8.5 0.4 μg/L

ERM-DA346 Testosterone in human serum 1.0 mL This material is intended for method validation and for monitoring the performance of methods commonly used in medical laboratories. ERM-DA346A was prepared from a single native female human serum pool. The material was sterile filtered and sub-sampled into plastic screw-cap 3 mL vials. Each vial contains a minimum of 0.8 mL. The certified value (mass fraction) is based on isotope dilution mass spectrometry. Certified value ...... 0.25 ± 0.04 μg/kg

ERM-DA345 Testosterone in human serum 1.0 mL This material is intended for method validation and for monitoring the performance of methods commonly used in medical laboratories. ERM-DA345A was prepared from a single native female human serum pool, part of which was spiked with testosterone in methanol to produce a material with a level of testosterone within the normal male range. The material was sterile filtered and sub-sampled into plastic screw-cap 3 mL vials. Each vial contains a minimum of 0.8 mL. The certified value (mass fraction) is based on isotope dilution mass spectrometry. Certified value ...... 5.58 ± 0.20 μg/kg

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Clinical applications

Code Product Unit Occupational health and hygiene materials in blood BCR-634 Lead and cadmium in reconstituted human blood (low) vial The material is supplied in lyophilised form in brown glass vials. Sodium-EDTA was used as anticoagulant. No other preservatives were added. The content of a vial is approximately 0.6 g dry matter with residual moisture content less than 2 % and equivalent to 3.0 mL of fresh whole blood. This material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV-1&2, Anti-HCV and Anti-HTLV-I&II. However, as all biological material of human origin the blood should be treated as contagious material. Analytes mass concentration Cd ...... 1.4 0.4 μg/L Pb ...... 46 5 μg/L

NIST-966 Toxic metals in blood unit This material is intended for use in evaluating the accuracy of lead, cadmium and total mercury concentration determinations in whole blood. It can also be used for validating analytical methods and for providing traceability to working or secondary blood reference materials containing these constituents. It contains frozen whole bovine blood with below mentioned components at two concentration levels. Analytes level 1 level 2 Pb ...... 1.459 0.013 .... 25.27 0.22 μg/dL Cd ...... 0.032 0.018 ...... 5.22 0.16 μg/L Hg (total) ...... 0.0445 0.0033 ...... 31.4 1.7 μg/L

SERO210105 Trace elements in whole blood, level 1 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 185 ng/L Hg ...... 1.97 μg/L S ...... 1100 mg/L Al ...... 11.2 μg/L Ho ...... 2.4 ng/L Sb ...... 2.35 μg/L As ...... 6.32 μg/L I...... 25.7 μg/L Sc ...... 46 ng/L Au ...... 7 ng/L Ir ...... < 0.2 ng/L Se ...... 104 μg/L B ...... 400 μg/L K ...... 1130 mg/L Si ...... 0.81 mg/L Ba ...... 542 μg/L La ...... 94 ng/L Sm...... 27 ng/L Be ...... 0.018 μg/L Li ...... 1 μg/L Sn ...... 0.42 μg/L Bi ...... 0.006 μg/L Lu ...... 0.8 ng/L Sr ...... 24 μg/L Br ...... 632 μg/L Mg ...... 16 mg/L Ta ...... 2.2 ng/L Ca ...... 14.5 mg/L Mn ...... 20.1 μg/L Tb ...... 2.2 ng/L Cd ...... 0.67 μg/L Mo ...... 0.8 μg/L Te ...... 0.11 μg/L Ce ...... 122 ng/L Na ...... 1467 mg/L Th ...... 12 ng/L Cs ...... 3 μg/L Nb ...... 57 ng/L Ti ...... 14 μg/L Co ...... 0.23 μg/L Nd ...... 96 ng/L Tl ...... 0.008 μg/L Cr ...... 0.82 μg/L Ni ...... 1.41 μg/L Tm ...... 1.2 ng/L Cu ...... 645 μg/L P ...... 216 mg/L U ...... 117 ng/L Dy ...... 12 ng/L Pb ...... 14.8 μg/L V ...... 1.1 μg/L Er ...... 9 ng/L Pd ...... < 10 ng/L W ...... 0.16 μg/L Eu ...... 11 ng/L Pr ...... 24 ng/L Y ...... 92 ng/L F ...... not analyzed Pt ...... 6 ng/L Yb ...... 9 ng/L Fe ...... 349 mg/L Rb ...... 1.47 mg/L Zn ...... 4810 μg/L Ga ...... 22 ng/L Re ...... 0.9 ng/L Zr ...... 681 ng/L Gd ...... 12 ng/L Rh ...... < 20 ng/L Hf ...... 9 ng/L Ru ...... < 50 ng/L

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Clinical applications

Code Product Unit SERO210205 Trace elements in whole blood, level 2 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 197 ng/L Hg ...... 15.2 μg/L S ...... 1071 mg/L Al ...... 71.8 μg/L Ho ...... 2.6 ng/L Sb ...... 28.4 μg/L As ...... 16.3 μg/L I ...... 81 μg/L Sc ...... 55 ng/L Au ...... 7 ng/L Ir ...... < 0.2 ng/L Se ...... 264 μg/L B ...... 356 μg/L K ...... 1108 mg/L Si ...... 0.812 mg/L Ba ...... 535 μg/L La ...... 103 ng/L Sm ...... 24 ng/L Be ...... 5.988 μg/L Li ...... 1.4 μg/L Sn ...... 6.1 μg/L Bi ...... 5.15 μg/L Lu ...... 1 ng/L Sr...... 24 μg/L Br...... 672 μg/L Mg ...... 15.6 mg/L Ta ...... 3.5 ng/L Ca ...... 14 mg/L Mn ...... 32.7 μg/L Tb ...... 2.1 ng/L Cd ...... 6.5 μg/L Mo ...... 6.6 μg/L Te ...... 0.072 μg/L Ce ...... 124 ng/L Na ...... 1443 mg/L Th ...... 11 ng/L Cs ...... 2.9 μg/L Nb ...... 70 ng/L Ti ...... 18 μg/L Co ...... 6 μg/L Nd ...... 99 ng/L Tl ...... 10.4 μg/L Cr ...... 12.4 μg/L Ni ...... 18.5 μg/L Tm ...... 1.3 ng/L Cu ...... 1248 μg/L P ...... 214 mg/L U...... 120 ng/L Dy ...... 13 ng/L Pb ...... 336 μg/L V ...... 5.9 μg/L Er...... 10 ng/L Pd ...... < 10 ng/L W ...... 0.158 μg/L Eu ...... 11 ng/L Pr ...... 25 ng/L Y ...... 123 ng/L F (*) ...... 100 μg/L Pt ...... 6 ng/L Yb ...... 10 ng/L Fe ...... 343 mg/L Rb ...... 1.44 mg/L Zn ...... 8406 μg/L Ga ...... 30 ng/L Re ...... 0.8 ng/L Zr ...... 731 ng/L Gd ...... 12 ng/L Rh ...... < 20 ng/L (*) added amount, not analyzed Hf...... 10 ng/L Ru ...... < 50 ng/L

SERO210305 Trace elements in whole blood, level 3 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 245 ng/L Hg ...... 31.4 μg/L S ...... 1066 mg/L Al ...... 112 μg/L Ho ...... 2.9 ng/L Sb ...... 87.1 μg/L As ...... 30.9 μg/L I ...... 189 μg/L Sc ...... 47 ng/L Au ...... 8 ng/L Ir ...... < 0.2 ng/L Se ...... 419 μg/L B ...... 467 μg/L K ...... 1111 mg/L Si ...... 1 mg/L Ba ...... 559 μg/L La ...... 145 ng/L Sm ...... 25 ng/L Be ...... 12.4 μg/L Li ...... 1.7 μg/L Sn ...... 12.1 μg/L Bi ...... 10.5 μg/L Lu ...... 1 ng/L Sr...... 25 μg/L Br...... 667 μg/L Mg ...... 15.6 mg/L Ta ...... 4.1 ng/L Ca ...... 14.2 mg/L Mn ...... 49.7 μg/L Tb ...... 2.5 ng/L Cd ...... 12.3 μg/L Mo ...... 12.9 μg/L Te ...... 0.065 μg/L Ce ...... 149 ng/L Na ...... 1437 mg/L Th ...... 13 ng/L Cs ...... 2.9 μg/L Nb ...... 91 ng/L Ti ...... 23 μg/L Co ...... 11.3 μg/L Nd ...... 106 ng/L Tl ...... 30.9 μg/L Cr ...... 37.3 μg/L Ni ...... 30.6 μg/L Tm ...... 1.5 ng/L Cu ...... 2401 μg/L P ...... 216 mg/L U...... 135 ng/L Dy ...... 14 ng/L Pb ...... 638 μg/L V ...... 13 μg/L Er...... 10 ng/L Pd ...... < 10 ng/L W ...... 0.205 μg/L Eu ...... 12 ng/L Pr ...... 29 ng/L Y ...... 117 ng/L F (*) ...... 200 μg/L Pt ...... 7 ng/L Yb ...... 12 ng/L Fe ...... 343 mg/L Rb ...... 1.5 mg/L Zn ...... 9381μg/L Ga ...... 28 ng/L Re ...... 0.9 ng/L Zr ...... 738 ng/L Gd ...... 14 ng/L Rh ...... < 20 ng/L (*) added amount, not analyzed Hf...... 9.5 ng/L Ru ...... < 50 ng/L

NIST-955C Lead in caprine blood 4 x 2 mL This material is intended primarily for use in evaluating the accuracy of lead concentration determinations in blood and for use in validating working or secondary reference materials for lead in blood analysis. This material replaced NIST-966. A unit consists of four vials of frozen caprine blood at four concentration levels: a base level and three progressively elevated levels that contain endogenous lead and spiked inorganic arsenic, cadmium, inorganic mercury, methylmercury, and ethylmercury. Certified values are provided for lead. Each vial contains approximately 2 mL of whole blood. Certified concentration Lead (μg/dL) Lead (μmol/L) Level 1 ...... 0.424 ± 0.011 ...... 0.02047 ± 0.00053 Level 2 ...... 13.950 ± 0.080 ...... 0.6733 ± 0.0038 Level 3 ...... 27.76 ± 0.16 ...... 1.3400 ± 0.0076 Level 4 ...... 45.53 ± 0.27 ...... 2.198 ± 0.013 The certificate is being updated to reflect additional concentration values for arsenic, cadmium, mercury (total), ethylmercury, inorganic mercury, and methylmercury.

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Clinical applications

Code Product Unit ERM-CE196 Lead and cadmium in bovine blood, high level Amp. Each sample is in lyophilised form equivalent to about 5.75 mL of bovine blood with additives, kept under nitrogen in rubber stoppered vials. Mass concentration in the reconstituted material Analytes Pb ...... 772 ± 11 μg/L Cd ...... 12.33 ± 0.20 μg/L

NCS ZC84010 Lead and cadmium in freeze-dried bovine blood I set (set of NCSZC84010 and 84011) NCS ZC84011 Lead and cadmium in freeze-dried bovine blood II set (set of NCSZC84010 and 84011) Occupational health and hygiene materials in serum NIST-1957 Organic contaminants in non-fortified human serum set (5) This material is intended for use in evaluating analytical methods for the determination of selected polychlorinated biphenyl (PCB) congeners, chlorinated pesticides, and polybrominated diphenyl ether (PBDE) congeners in human serum and similar matrices. A unit of NIST-1957 consists of five bottles of freeze-dried non- fortified human serum which should be reconstituted with 10.7 mL of water. Certified values are given for eight PCB congeners (some in combination), three chlorinated pesticides, and four PBDE congeners along with one polybrominated biphenyl congener. In addition, reference values are provided for 23 other PCB Congeners, chlorinated pesticides and PBDE congeners, for seven perflourinated compounds (PFCs), for eleven polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Information values are provided for two hydroxylated compounds and for Aroclor 1260. All of the constituents for which certified and reference values are provided in SRM 1957 are naturally present in the serum. Certified values (mass fraction) in ng/kg PCB 118 ...... 18.5 ± 2.7 trans-Nonachlor ...... 59.9 ± 0.5 PCB 138 ...... 36.9 ± 5.4 4,4'-DDE ...... 940 ± 78 PCB 153 ...... 57.2 ± 3.3 PBDE 47 ...... 272 ± 14 PCB 170 ...... 16.7 ± 2.6 PBDE 99 ...... 77.8 ± 1.7 PCB 180 ...... +193 54.4 ± 1.3 PBDE 100 ...... 50.5 ± 2.5 PCB 187 ...... 15.7 ± 0.9 PBDE 153 ...... 62.1 ± 3.0 PCB 194 ...... 12.0 ± 0.5 PBB 153 ...... 15.8 ± 1.0 Hexachlorobenzene ...... 30.3 ± 4.1

BCR-637 Trace elements in human serum (Al, Se, Zn) vial The CRM is supplied in frozen form in white plastic vials. The serum was sterile filtered prior to filling and no preservatives were added. The content of a vial is approximately 4.5 mL serum.This serum material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV- 1&2, Anti-HCV and Anti-HTLV-I&II. Element mass concentration Al ...... 12.5 μg/L Se ...... 81 μg/L Zn ...... 1.11 mg/L

BCR-638 Trace elements in human serum (Al, Se, Zn) vial The CRM is supplied in frozen form in white plastic vials. The serum was sterile filtered prior to filling and no preservatives were added. The content of a vial is approximately 4.5 mL serum. This serum material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV- 1&2, Anti-HCV and Anti-HTLV-I&II. Element mass concentration Al ...... 55 μg/L Se ...... 104 μg/L Zn ...... 1.43 mg/L

BCR-639 Trace elements in human serum (Al, Se, Zn) vial The CRM is supplied in frozen form in white plastic vials. The serum was sterile filtered prior to filling and no preservatives were added. The content of a vial is approximately 4.5 mL serum.This serum material was produced from blood from healthy Danish blood donors. Each portion of blood was tested negative for Anti-HIV- 1&2, Anti-HCV and Anti-HTLV-I&II. Element mass concentration Al ...... 194 μg/L Se ...... 133 μg/L Zn ...... 2.36 mg/L

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Clinical applications

Code Product Unit SERO201405 Trace elements in serum, level 1 6 x 3 mL This reference material is produced from serum collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. Contains all normal constituents which ensure the control and test samples to be analysed under the same conditions. Certified values after reconstitution Al ...... 33.6 μg/L Hg ...... 0.62 μg/L Sc ...... 7.6 ng/L Ag ...... 0.16 μg/L Ho ...... 1.9 ng/L Se ...... 107 μg/L As ...... 0.47 μg/L I ...... 84 μg/L Si ...... 0.74 mg/L Au ...... 540 μg/L Ir ...... 1.2 ng/L Sm ...... 7.7 ng/L B ...... 154 μg/L K ...... 126 mg/L Sn ...... 0.52 μg/L Ba ...... 126 μg/L La ...... 39.5 ng/L Sr...... 26.3 μg/L Be ...... 1.8 ng/L Li ...... 5741 μg/L Ta ...... 3.1 ng/L Bi ...... 3.7 ng Lu ...... 0.7 ng/L Te ...... 29 ng/L Br...... 488 μg/L Mn ...... 15 μg/L Tb ...... 1.3 ng/L Ca ...... 94.2 mg/L Mg ...... 20.1 mg/L Th ...... 2.9 ng/L Cd ...... 0.126 μg/L Mo ...... 0.7 μg/L Ti ...... 11.2 μg/L Ce ...... 38.7 ng/L Na ...... 2998 mg/L Tl ...... 23 ng/L Cr ...... 1.5 μg/L Nb ...... 40 ng/L Tm ...... 0.9 ng/L Cs ...... 18.6 ng/L Nd ...... 22.8 ng/L U...... 48 ng/L Co ...... 1.2 μg/L Ni ...... 5.8 μg/L V ...... 0.96 μg/L Cu ...... 1691 μg/L P ...... 70 mg/L W ...... 91 ng/L Dy ...... 3.5 ng/L Pb ...... 1.02 μg/L Y ...... 19 ng/L Er...... 3.5 ng/L Pr ...... 7.4 ng/L Yb ...... 2.5 ng/L F (*) ...... 75 μg/L Pt ...... 6.9 ng/L Zn ...... 1738 μg/L Fe ...... 1.39 mg/L Rb ...... 5.25 μg/L Zr ...... 278 ng/L Ga ...... 8.9 ng/L Re ...... 1.7 ng/L (*) added amount, not analyzed Gd ...... 5.2 ng/L S ...... 1448 mg/L Hf...... 5.7 ng/L Sb ...... 80 μg/L

SERO203105 Trace elements in serum, level 2 6 x 3 mL This reference material is produced from serum collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. Contains all normal constituents which ensure the control and test samples to be analysed under the same conditions. Certified values after reconstitution Al ...... 111 μg/L Ge ...... < 400 ng/L Ru ...... < 15 ng/L Ag ...... 343 ng/L Hf ...... 33 ng/L S ...... 1330 mg/L Ar...... 343 ng/L Hg ...... 1.86 μg/L Sb ...... 21 μg/l As ...... < 1 μg/L Ho ...... 9 ng/L Sc ...... 57 ng/L Au ...... 1956 μg/L I ...... 54 μg/L Se ...... 136 μg/L B ...... 41 μg/L Ir ...... 1.2 ng/L Si ...... 2.1 mg/L Ba ...... 271 μg/L K ...... 236 mg/L Sm ...... 45 ng/L Be ...... 18 ng/L La ...... 315 ng/L Sn ...... 2.86 μg/L Bi ...... 21 ng Li ...... 10.6 mg/L Sr...... 130 μg/L Br...... 656 μg/L Lu ...... 3.4 ng/L Ta ...... 3.2 ng/L Ca ...... 117 mg/L Mn ...... 19.1 μg/L Tb ...... 5.4 ng/L Cd ...... 317 ng/L Mg ...... 28.9 mg/L Te ...... 19 ng/L Ce ...... 285 ng/L Mo ...... 1.31 μg/L Th ...... 45 ng/L Cr ...... 5.2 μg/L Na ...... 3783 mg/L Ti ...... 3.0 μg/L Cs ...... 22 ng/L Nb ...... 42 ng/L Tl ...... 34 ng/L Co ...... 3.2 μg/L Nd ...... 249 ng/L Tm ...... 3.1 ng/L Cu ...... 2.6 mg/L Ni ...... 10.7 μg/L U...... 0.98 μg/L Dy ...... 30 ng/L P ...... 42 mg/L V ...... 1.12 μg/L Er...... 20 ng/L Pb ...... 3 μg/L W ...... 84 ng/L Eu ...... 12 ng/L Pd ...... < 10 ng/L Y ...... 243 ng/L F (added amount) ...... 200 μg/L Pr ...... 69 ng/L Yb ...... 21 ng/L Fe ...... 1.91 mg/L Pt ...... 17 ng/L Zn ...... 0.92 mg/L Ga ...... 46 ng/L Rb ...... 7.2 μg/L Zr ...... 2.4 μg/L Gd ...... 41 ng/L Re ...... 6.3 ng/L

ERM-DA120 Frozen human serum - Trace metals (Cu, Se, Zn) 1 ml This reference materials is intended for use in the validation of new methods monitoring the performance of methods commonly used in laboratories to determine the important trace elements copper, selenium and zinc in human serum samples. The material is clinically relevant since it closely matches the lower level of the normal range for serum selenium in the population. The material has been certified using isotope dilution inductively - coupled plasma mass spectrometry (ID-IRPMS). Certified values Cu ...... 1130 μg/kg Se ...... 64.1 μg/kg Zn ...... 658 μg/kg

Occupational health and hygiene materials in urine NIST-RM 8444 Cotinine in human urine 4 x 5 mL This standard is intended primarily for use in validating methods for the determination of cotinine in human urine. One set consists of four vials, each containing cotinine in 5 ml human urine, which has been freeze dried. Two vials are “blank” concentration levels, typical for non-smokers without exposure to cigarette smoke, one vial is a “low” concentration level corresponding to non-smokers with passive exposure to side-stream smoke, and one vial is a “high” level, typical of smokers. Analyte blank low high ng/mL ng/mL ng/mL Cotinine ...... 0.8 ...... 54...... 488

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Code Product Unit NIST-2672A Mercury in urine set (4) This material is intended primarily for use as an analytical standard for the determination of mercury in urine. It consists of four bottles of freeze-dried urine containing mercury, two bottles each at low and elevated levels. Certified values after reconstitution low level elevated level Hg ...... (0.002) ...... 0.105 mg/L

SERO201205 Trace elements in urine, level 2 10 x 5 mL This reference material is produced from human urine from thoroughly controlled voluntary Norwegian donors. Each unit is controlled by official authorities and found negative for presence of HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensure the control and test samples to be analysed under the same conditions. Certified values after reconstitution Analyte Ag ...... 26 ng/L I...... 304 μg/L Sm...... 4.3 ng/L Al ...... 100 μg/L Ir ...... 0.16 ng/L Sn ...... 54.6 μg/L As ...... 142 μg/L K ...... 1903 mg/L Sr ...... 110 μg/L Au ...... 24 ng/L La ...... 31 ng/L Ta ...... 9 ng/L B ...... 869 μg/L Li ...... 10.2 μg/L Tb ...... 1.2 ng/L Ba ...... 51 μg/L Lu ...... 0.9 ng/L Te ...... 25.3 μg/L Be ...... 4.9 μg/L Mg ...... 71.mg/L Th ...... 2.5 ng/L Bi ...... 20.1 μg/L Mn ...... 12.3 μg/L Ti ...... 17.8 μg/L Br ...... 2 mg/L Mo ...... 49.3 μg/L Tl ...... 9.26 μg/L Ca ...... 107 mg/L Na ...... 2307 mg/L Tm ...... 0.3 ng/L Cd ...... 4.6 μg/L Nb ...... 57 ng/L U ...... 65.5 ng/L Ce ...... 77 ng/L Nd ...... 16.2 ng/L V ...... 25.2 μg/L Cl ...... 127 mmol/L Ni ...... 50.4 μg/L W ...... 0.17 μg/L Co ...... 10 μg/L P ...... 702 mg/L Y ...... 15 ng/L Cu ...... 72 μg/L Pb ...... 40.3 μg/L Yb ...... 1.1 ng/L Cr ...... 19.7 μg/L Pd ...... <10 ng/L Zn ...... 1168 μg/L Cs ...... 6.79 μg/L Pr ...... 9.5 ng/L Zr ...... 81 ng/L Dy ...... 1.9 ng/L Pt ...... 8.1 ng/L Creatinine ...... 8663 μmol/L Er ...... 2.2 ng/L Rb ...... 1.17 mg/L 1-Hydroxypyrene ...... 55 μg/L* Eu ...... 1.9 ng/L Re ...... 78 ng/L Formic acid ...... 10.8 mg/L* F ...... 4 mg/L* Rh ...... <50 ng/L Phenol ...... 300 mg/L* Fe ...... 12.3 μg/L Ru ...... <200 ng/L Mandelic acid ...... 490 μg/L* Ga ...... 37 ng/L S ...... 543 mg/L Tetrachloroethylene . 1000 μg/L* Gd ...... 4.5 ng/L Sb ...... 99.9 μg/L TCA ...... 350 μmol/L* Hf ...... 1 ng/L Sc ...... 103 ng/L (*) added amount, not analyzed Hg ...... 40.7 μg/L Se ...... 58.6 μg/L Ho ...... 4.6 ng/L Si ...... 5.2 mg/L

Occupational health and hygiene materials in other matrices NIST-1400 Trace elements in bone ash 50 g This standard is intended primarily for use in evaluating analytical methods for the determination of selected major, minor and trace elements in bone and in material of a similar matrix. It consists of bone ash that was blended to high degree of homogeneity. Certified values Ca ...... 38.18 ± 0.13 % Mg ...... 0.684 ± 0.013 % Sr ...... 249 ± 7 μg/g Fe ...... 660 ± 27 μg/g P ...... 17.91 ± 0.19 % Zn ...... 181 ± 3 μg/g K ...... 186 ± 8 μg/g Pb ...... 9.07 ± 0.12 μg/g

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Clinical applications

Code Product Unit NIST-1486 Trace elements in bone meal 50 g This standard is intended primarily for use in evaluating analytical methods for the determination of selected major, minor and trace elements in bone and in material of similar matrix. It consists of steamed bone meal that was sieved and blended to a high degree of homogeneity. Certified values Ca ...... 26.58 ± 0.24 wt% Fe ...... 99 ± 8 μg/g Sr...... 264 ± 7 μg/g Mg ...... 0.466 ± 0.017 wt% K ...... 412 ± 4 μg/g Zn ...... 147 ± 16 μg/g P ...... 12.30 ± 0.19 wt% Pb ...... 1.335 ± 0.014 μg/g

BCR-665 Asbestos fibres in human lung 100 mg The sample consists of at least 100 mg of homogenised and sterilised (gamma irradiated at 25 kGy) human lung tissue. Type of fibre number of fibres * Amosite + crocidolite ...... 49 Anthophyllite ...... 1.8 * of more than 1 μm in length in million per g dry tissue

BCR-666 Asbestos fibres in lung tissue 100 mg The sample consists of at least 100 mg of homogenised and sterilised (gamma irradiated at 25 kGy) human lung tissue. Type of fibre number of fibres * Amosite + crocidolite ...... 2.3 Anthophyllite ...... 5.1 *of more than 1 μm in length in million per g dry tissue

NCSZC81002B Trace elements in human hair 7 g Analytes μg/g Analytes μg/g Analytes μg/g Ag ...... 0.037 ± 0.002 Cu ...... 33.6 ± 2.3 Ni ...... (5.77) Al ...... 23.2 ± 2.0 Fe ...... 160 ± 16 P ...... 174 ± 43 As ...... 0.198 ± 0.023 Hg ...... 1.06 ± 0.28 S ...... (4.62 in %) Ba ...... 11.1 ± 1.3 I ...... 0.96 ± 0.20 Pb ...... 3.83 ± 0.18 Br...... (0.59) K ...... (14.4) Sb ...... 0.12 ± 0.02 Ca ...... 1537 ± 68 La ...... (0.029) Se ...... 0.59 ± 0.04 Cl ...... (48.2) Mg ...... 284 ± 14 Sr...... 8.17 ± 0.69 Cd ...... 0.072 ± 0.010 Mn ...... 3.83 ± 0.39 V ...... (0.089) Co ...... 0.153 ± 0.015 Mo ...... 1.06 ± 0.12 Zn ...... 191 ± 16 Cr ...... 8.74 ± 0.97 Na ...... 445 ± 40

Proteins BCR-486 Alphafoetoprotein (AFP), human purified Amp. Each sample is in the lyophilised form and it contains purified AFP without additives. The material is kept under nitrogen gas in sealed glass ampoules. The protein mass per ampoule is equivalent to 100 ± 9 μg when the material is reconstituted. Carbohydrate mass of the molecule is not included. Protein mass per ampoule ...... 100 ± 9 μg

BCR-393 Apolipoprotein AI, human Amp. Each sample is in the lyophilised form of a 1.5 mL portion of Apo AI solution without additives. The material is kept under nitrogen gas in sealed glass ampoules. Mass concentration in the reconstituted material ...... 1.06 ± 0.05 g/L

HEC JDS2 HbA1c in haemoglobin in buffer unit JDS HbA1c Lot 2 is primarily intended for use in the calibration and standardization of procedures for measurement of Haemoglobin A1c in clinical specimens. It can also be used for validating working or secondary reference materials. The material consists of a lysed solution (carbonate buffer) of erythrocytes originating from human whole blood. The material is free from plasma components and without stabilisers. A single set of JDS HbA1c Lot 2 consists of five vials (0.1 mL) with concentrations levels 4-13%. Certified values: Level HbA1c (%) 1 ...... 4.040.08 2 ...... 5.380.05 3 ...... 7.320.07 4 ...... 9.880.10 5 ...... 12.630.13

BCR-273 Single cell protein 10 g The material consists of about 10 g single cell protein powder in a sealed argon filled ampoule. Certified values Ca ...... 11.97 g/kg K ...... 2.22 g/kg P ...... 26.8 g/kg Fe ...... 0.156 mg/kg N ...... 121.6 g/kg Indicative values for Mg, N (Kjeldahl), Na, S

BCR-613 Prostate specific antigen (PSA) Amp. Each sample is in lyophilised form and it contains purified PSA without additives. The material is kept under argon gas in sealed glass ampoules. Carbohydrate mass of the molecule not included. Prostate specific antigen in the reconstituted material Mass concentration...... 71 ± 7 μg

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Clinical applications

Code Product Unit BCR-457 Thyroglobulin (Tg), human Amp. Each sample is in lyophylised form and equivalent to about 100 μl of purified Tg without additives. The material is kept under nitrogen in sealed glass ampoules. Mass concentration in the reconstituted material ...... 0.324 ± 0.018 g/L

Proteins in blood IRMM/IFCC-467 Haemoglobin HbA0 in whole blood isolate vial The intended use of this reference material is the calibration of the IFCC reference measurement procedure and those analogous methods targeting the N-terminal hexapeptide with a stable glycation. A unit of IRMM/IFCC-467 consists of a glass vial with deep frozen HbA0-containing buffered solution (50 mmol/L MES, 10 mmol/L KCN, 2 mmol/L EDTA, pH 6.2). It was prepared from whole blood obtained from healthy volunteers. The certified value, the amount-of-substance fraction of HbA0 (defined as defined as the non-glycated haemoglobin), is traceable to the SI. An indicative value for total haemoglobin mass fraction (119.7 ± 3.7 mg/g) is also provided. Certified value HbA /(HbA + HbA ) ...... > 976 mmol/mol 0 0 1c BCR-522 Haemiglobincyanide (HiCN) in bovine blood lysate Amp. Each sample is in the form of bovine blood lysate and a mass concentration of about 800.3 mg/L haemiglobincyanide with a volume of 10 mL. The material is kept in sealed brown neutral borosilicate glass ampoules. Molar mass and molar extinction coefficient of bovine haemoglobin and human haemoglobin have been shown to be equivalent. Absorbance at 540 nm HiCN ...... 0.5457 ± 0.0009 Concentration HiCN ...... 800.3 ±1.3 mg/L HiCN (Fe) ...... 49.61 ± 0.08 μmol/L

Proteins in serum Seronorm Immunoprotein (serum controls for clinical chemistry) These materials are intended for use as control materials for clinical chemical work. They are provided at two relevant diagnostic levels and consist of freeze-dried human serum which should be reconstituted with water. The materials are suitable for analysis with electrophoresis. No preservatives or stabilisers are added. The materials are stable for three years at 2 - 8 °C in unopened vials. The content of opened vials is stable for seven days at 2 - 8 °C. The materials are characterised for the following proteins: Alfa1-acid-glycoprotein C3c Ferritin Prealbumin Alfa1-antitrypsin C4 Haptoglobin Protein, total Alfa2-macroglobulin CCP IgA RF Albumin CDT (only in L-1) IgE Transferrin Apolipoprotein A1 Ceruloplasmin IgG ASL/ASO CRP IgM -microglobulin Digitoxin Myoglobin 2 SERO202805 Seronorm Immunoprotein Level 1 (serum control for clinical chemistry) 6 x 1 mL SERO202905 Seronorm Immunoprotein Level 2 (serum control for clinical chemistry) 6 x 1 mL SERO200905 Seronorm protein 6 x 1 mL (serum control for clinical chemistry) The material is intended for accuracy control of the most frequently analysed serum proteins. It is a stable freeze-dried human serum where both ß- and pre ß-lipoproteins have been removed. Most values are traceable to ERM-DA470 and each batch is supplied with a data key providing analytical values for each protein. The levels of each protein are targeted to improve analytical quality where it is of greatest importance for clinical decision, just outside the reference intervals. By an inversion of Albumin, the Total Protein is almost identical in Seronorm™ Protein. Assayed or reference values are provided for the following proteins: albumin IgA 1-antitrypsin IgG 2-microglobulin* IgE C1q* IgM C3c 1-acid-glycoprotein (orosomucoid) C4 2-macroglobulin ceruloplasmin total protein CRP* transferrin ferritin transthyretin (prealbumin) haptoglobin

NIST-2921 Human cardiac Troponin complex 5 x 115 μL This material is primarily intended for use in calibrating clinical procedures and devices for the determination of cardiac troponin I (cTnI) in human serum. It can also be used for value-assignment of calibrators and control materials. A unit of consists of five vials, each containing approximately 115 μL of a dilute solution of human cardiac troponin complex. cTnI ...... 31.2 mg/L ± 1.4 mg/L

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Clinical applications

Code Product Unit ERM-DA470K/IFCC Proteins in human serum Amp. This material is primarily intended to be used for the calibration of immunoassay-based in-vitro diagnostic devices or control products for the certified protein. Each sample is the lyophilised form of a 1.0 mL portion of serum with additives (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), sodium azide, benzamidine hydrochloride, sodium chloride and aprotinin). The material is kept under nitrogen gas in threaded glass bottles. The material has to be reconstituted with distilled water. The serum was produced from blood collected according to a procedure ensuring healthy donors, and low lipid content. The serum was processed in batches, pooled, spiked with B2M and CRP, lyophilised in the vials, and stored at - 70°C. Nephelometry, turbidimetry or spectrophotometry in different commercial platform/reagent combinations were used to measure protein concentrations. Certified values (mass concentration in the reconstituted material): Certified values g/L 2 macroglobulin (A2M) ...... 1.43 ± 0.06 1 acid glycoprotein (AAG)...... 0.617 ± 0.013 1 antitrypsin (AAT) ...... 1.12 ± 0.03 albumin (ALB) ...... 37.2 ± 1.2 complement 3c (C3c)...... 1.00 ± 0.04 complement 4 (C4) ...... 0.162 ± 0.007 haptoglobin (HPT) ...... 0.889 ± 0.021 immunoglobulin A (IgA) ...... 1.80 ± 0.05 immunoglobulin G (IgG) ...... 9.17 ± 0.18 immunoglobulin M (IgM) ...... 0.723 ± 0.027 transferrin (TRF) ...... 2.36 ± 0.08 transthyretin (TTR) ...... 0.220 ± 0.018 ERM-DA471K/IFCC Cystatin C in human serum vial Each sample consists of lyophilised human serum spiked with cystatin C. It contains the following additives: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), sodium azide, benzamidine chloride and aprotinin. The material is kept under nitrogen gas in siliconised glass vials. Mass concentration measured in the reconstituted material Certified value ...... 5.48 ± 0.15 mg/L

ERM-DA472/IFCC C-reactive protein (CRP) in human serum 1 mL The material is primarily intended to be used to calibrate serum-based protein standards and control materials of organisations which offer such preparations for the quantification of CRP by immunoassay. Each sample consists of at least 1 mL processed human serum spiked with CRP. It contains the following additives: (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), sodium azide, bezamidine chloride and aprotinin). The material is kept under argon gas in duran glass ampoules. When the material is used as a calibrant in a particular assay the commutability should be verified for the assay concerned. The certified value was established using the ERM-DA470 material in combination with a value transfer procedure. Certified value (mass concentration) ...... 41.8 ± 2.5 mg/l

Proteins in other matrices BCR-405 Glycated haemoglobin (HbAlc) in human haemolysate (RM) Amp. Each sample is in lyophilised form and equivalent to about 0.5 mL of a solution of haemolysate of human erythrocytes without preservatives. The material is kept under carbon monoxide in sealed glass ampoules. HbA in reconstituted material .... 62.9 ± 1.8 g/kg % 1C Veterinary materials BCR-386 Diethylstilboestrol (DES) in bovine urine, blank vial Diethylstilboestrol concentration in the reconstituted material ...... < 0.1 μg/L The material consists of lyophilised bull urine obtained from animals which have never been treated with stilbenes. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen.

BCR-389 Diethylstilboestrol (DES) in bovine urine, positive vial Diethylstilboestrol concentration in the reconstituted material...... 12.8 ± 2.5 μg/L The material consists of lyophilised bull urine mixed with friesian steer urine biologically incurred with diethylstilbestrol. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen.

BCR-387 Dienoestrol (DE) in bovine urine, blank vial Dienoestrol concentration in the reconstituted material……. < 0.1 μg/L The material consists of lyophilised calf urine obtained from animals which have never been treated with stilbenes. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen.

BCR-390 Dienoestrol (DE) in bovine urine, positive vial The material consists of lyophilised calf urine mixed with friesian steer urine biologically incurred with dienoestrol. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen. Dienoestrol concentration in the reconstituted material ...... 34 ± 7 μg/L.

BCR-388 Hexoestrol (HEX) in bovine urine, blank vial Hexoestrol concentration in the reconstituted material...... < 0.1 μg/L The material consists of lyophilised cow urine obtained from animals which have never been treated with stilbenes. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen.

BCR-391 Hexoestrol (HEX) in bovine urine, positive vial The material consists of lyophilised cow urine mixed with friesian steer urine biologically incurred with hexoestrol. It is supplied in vials with a content equivalent to about 2.0 mL urine, sealed under nitrogen. Hexoestrol concentration in the reconstituted material...... 13.3 ± 3.1 μg/L.

NMIAD926 5(10)-Estrene-3beta,17alfa-diol 1 mg

32 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Clinical applications

Code Product Unit Vitamins and micronutrients NIST-970 Ascorbic acid in frozen human serum set (4) This material is intended primarily for use in validating methods for determine ascorbic acid in human serum and similar matrices. It can also be used for quality assurance when assigning values to in-house control materials. A unit consists of four ampoules of frozen human serum, two ampoules each of level I (high normal) and level II (low normal). Each ampoule contains approximately 2.2 mL of solution, a 1:1 mixture of human serum and 100 g/L (10 % mass concentration) aqueous metaphosphoric acid (MPA). The MPA is present to stabilize and preserve the ascorbic acid. Certified concentration values for total ascorbic acid (TAA) (ascorbic acid + dehydroascorbic acid). Levels value 95 % confidence level I, μmol/L of solution ...... 8.41 ...... 7.75 to 9.07 level II, μmol/L of solution ...... 28.05 ...... 27.56 to 28.54

NIST-2972 25-Hydroxyvitamin D2 and D3 calibration solutions 10 x 1.2 mL This material consists of two separate solutions of the vitamin D metabolites 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in ethanol. It is intended primarily for use in calibration of instruments and techniques used for the determination of these metabolites. A unit consists of ten 2 mL ampoules, five of which contain approximately 1.2 mL of the 25-hydroxyvitamin D2 solution and five of which contain approximately 1.2 mL of the 25-hydroxyvitamin D3 solution. Certified values mass fraction ng/g concentration nmol/L 25-hydroxyvitamin D2 ...... 302.9 ± 4.9 ...... 578.3 ± 18.0 25-hydroxyvitamin D3 ...... 425.0 ± 6.6 ...... 835.6 ± 25.8

NIST-972 Vitamin D in human serum 4 x 1.0 mL This material is intended for use as an accuracy control in the evaluation of methods for determining the concentration of vitamin D metabolites in human serum. The material can also be used as a quality assurance tool for assigning values to in-house control materials for these constituents. A unit of the material consists of four vials (Levels 1-4) of frozen serum with different concentration levels of 25-hydroxyvitamin D [25(OH)D]. Certified values are given as mass factions (below), and as mass concentrations and amount-of-substance concentrations (see certificate). Non-certified values are provided for some of the metabolites. Certified value (ng/g) Level 1 25-hydroxyvitamin D3 ...... 23.2 ± 0.8 Level 2 25-hydroxyvitamin D2 ...... 1.67 ± 0.08 25-hydroxyvitamin D3 ...... 12.0 ± 0.6 Level 3 25-hydroxyvitamin D2 ...... 25.8 ± 1.9 25-hydroxyvitamin D3 ...... 18.1 ± 1.1 Level 4 25-hydroxyvitamin D2 ...... 2.35 ± 0.21 25-hydroxyvitamin D3 ...... 32.3 ± 0.8 3-epi-25-hydroxyvitamin D3 ...... 36.9 ± 1.1

CERH-090 1alpha, 25-Dihydroxyvitamin D2 (5 μg/ml ) 1 mL in Ethanol CERH-089 1alpha, 25-Dihydroxyvitamin D3 (5 μg/ml ) 1 mL in Ethanol CERH-073 25-Hydroxyvitamin D2 (0.05 mg/ml) 1 mL in Ethanol CERH-087 25-Hydroxyvitamin D2 (5 μg/ml ) 1 mL in Ethanol CERH-083 25-HydroxyvVitamin D3 (1.0 mg/ml) 1 mL in Ethanol CERH-086 25-Hydroxyvitamin D3 (5 μg/ml) 1 mL in Ethanol CERH-074 D6-25-Hydroxyvitamin D3 (26,26,26,27,27,27-D6) (0.05 mg/mL) 1 mL in Ethanol TRC-C125700 Calcifediol (25-Hydroyvitamin D3) 10 mg TRC-H995820 25-Hydroxyvitamin D2 25 mg

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Clinical applications

Code Product Unit TRC-C144500 Calcitriol 1,25-Dihydroxyvitamin D3 2.5 mg CDX-00003035-001 Calcitriol 1 mg CDX-00003035-500 Calcitriol 0.5 mg TRC-C125702 Calcifediol-D6 0.5 mg TRC-C144502 Calcitriol-d6 10 mg Various control materials SERO203005 Seronorm Human, high (serum control for clinical chemistry) 10 x 5 mL Freeze dried human serum control covering over 40 of the most frequently analysed components at levels of clinical interest. The human serum from which this product has derived is from thoroughly controlled voluntary, unpaid donors of Scandinavian blood centres. Each unit is tested negative to HBs antigen, HCV - HIV-I - HIV-II antibodies by approved tests. Analytes: ALAT CK-MB IgM T3, free Albumin Copper IgG T3, total ALP Creatinine Iron T4, free Amylase, pancreas CRP Lactate T4, total Amylase, total Digoxin LDH Testosterone ASAT Estradiol Lipase Theophylline Bile Acid Ferritin Lithium TIBC Bilirubin,direct Folate Magnesium Transferrin Bilirubin, total GGT Osmolality Triglycerides Calcium GLDH Phenylalanin TSH Chloride Glucose Phosphorus UIBC Cholesterol, HDL/LDL HBDH Potassium Urea Cholesterol, total hCG, total Progesterone Uric acid Cholinesterase Homocysteine Protein, total Vitamin B12 CK IgA Sodium Zinc

Seronorm Immunoassay (serum controls for clinical chemistry) Liquid human serum control. Immunoassay control combining hormones, cardiac, and tumour markers and covering over 40 of the most frequently analysed components at levels of clinical interest. The human based matrix has been produced with focus on compatibility with patient samples. No preservatives or stabilisers are added Human serum, from which this product has derived, is from thoroughly controlled voluntary unpaid donors of Scandinavian Blood Centres. Each unit is tested negative for Hbsantigen, HCV - HIV-I - HIV-II antibodies by approved tests. Three levels of clinical significance - each level available separately. Freeze-dried (assayed values) or liquid control (approx values) available. Analytes: 17-OH-Progesterone C-peptide IgE T3 free AFP Cortisol Insulin T3 total Aldosterone DHEA-Sulphate LH T4 free Androstendione Digoxin Metylmalonic acid T4 total Anti-TPO Estradiol Myoglobin TBG 2-microglobulin Estriol,free NT-pro-BNP Testosterone -hCG, total Ferritin Progesterone Theophylline CA 125 Folate Prolactin Thyreoglobulin CA 15-3 FSH PTH (intact) Troponin I CA 19-9 hCG,total PSA, free Troponin T CEA hGH PSA, total TSH CK-MB Homocysteine SHBG Vitamin B 12 SERO207005 Seronorm Immunoassay Liquid L-1 (serum control for clinical chemistry) 12 x 3 mL SERO207205 Seronorm Immunoassay Liquid L-3 (serum control for clinical chemistry) 12 x 3 mL

SERO206005 Seronorm Immunoassay Lyo L-1 (serum control for clinical chemistry) 12 x 3 mL

SERO206105 Seronorm Immunoassay Lyo L-2 (serum control for clinical chemistry) 12 x 3 mL SERO206205 Seronorm Immunoassay Lyo L-3 (serum control for clinical chemistry) 12 x 3 mL SERO203405 Seronorm Immunoassay L-3, low (serum control for clinical chemistry) 12 x 3 mL

34 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Clinical applications

Code Product Unit SERO210105 Trace elements in whole blood, level 1 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 185 ng/L Hg ...... 1.97 μg/L S ...... 1100 mg/L Al ...... 11.2 μg/L Ho ...... 2.4 ng/L Sb ...... 2.35 μg/L As ...... 6.32 μg/L I...... 25.7 μg/L Sc ...... 46 ng/L Au ...... 7 ng/L Ir ...... < 0.2 ng/L Se ...... 104 μg/L B ...... 400 μg/L K ...... 1130 mg/L Si ...... 0.81 mg/L Ba ...... 542 μg/L La ...... 94 ng/L Sm...... 27 ng/L Be ...... 0.018 μg/L Li ...... 1 μg/L Sn ...... 0.42 μg/L Bi ...... 0.006 μg/L Lu ...... 0.8 ng/L Sr ...... 24 μg/L Br ...... 632 μg/L Mg ...... 16 mg/L Ta ...... 2.2 ng/L Ca ...... 14.5 mg/L Mn ...... 20.1 μg/L Tb ...... 2.2 ng/L Cd ...... 0.67 μg/L Mo ...... 0.8 μg/L Te ...... 0.11 μg/L Ce ...... 122 ng/L Na ...... 1467 mg/L Th ...... 12 ng/L Cs ...... 3 μg/L Nb ...... 57 ng/L Ti ...... 14 μg/L Co ...... 0.23 μg/L Nd ...... 96 ng/L Tl ...... 0.008 μg/L Cr ...... 0.82 μg/L Ni ...... 1.41 μg/L Tm ...... 1.2 ng/L Cu ...... 645 μg/L P ...... 216 mg/L U ...... 117 ng/L Dy ...... 12 ng/L Pb ...... 14.8 μg/L V ...... 1.1 μg/L Er ...... 9 ng/L Pd ...... < 10 ng/L W ...... 0.16 μg/L Eu ...... 11 ng/L Pr ...... 24 ng/L Y ...... 92 ng/L F ...... not analyzed Pt ...... 6 ng/L Yb ...... 9 ng/L Fe ...... 349 mg/L Rb ...... 1.47 mg/L Zn ...... 4810 μg/L Ga ...... 22 ng/L Re ...... 0.9 ng/L Zr ...... 681 ng/L Gd ...... 12 ng/L Rh ...... < 20 ng/L Hf ...... 9 ng/L Ru ...... < 50 ng/L

SERO210205 Trace elements in whole blood, level 2 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 197 ng/L Hg ...... 15.2 μg/L S ...... 1071 mg/L Al ...... 71.8 μg/L Ho ...... 2.6 ng/L Sb ...... 28.4 μg/L As ...... 16.3 μg/L I...... 81 μg/L Sc ...... 55 ng/L Au ...... 7 ng/L Ir ...... < 0.2 ng/L Se ...... 264 μg/L B ...... 356 μg/L K ...... 1108 mg/L Si ...... 0.812 mg/L Ba ...... 535 μg/L La ...... 103 ng/L Sm...... 24 ng/L Be ...... 5.988 μg/L Li ...... 1.4 μg/L Sn ...... 6.1 μg/L Bi ...... 5.15 μg/L Lu ...... 1 ng/L Sr ...... 24 μg/L Br ...... 672 μg/L Mg ...... 15.6 mg/L Ta ...... 3.5 ng/L Ca ...... 14 mg/L Mn ...... 32.7 μg/L Tb ...... 2.1 ng/L Cd ...... 6.5 μg/L Mo ...... 6.6 μg/L Te ...... 0.072 μg/L Ce ...... 124 ng/L Na ...... 1443 mg/L Th ...... 11 ng/L Cs ...... 2.9 μg/L Nb ...... 70 ng/L Ti ...... 18 μg/L Co ...... 6 μg/L Nd ...... 99 ng/L Tl ...... 10.4 μg/L Cr ...... 12.4 μg/L Ni ...... 18.5 μg/L Tm ...... 1.3 ng/L Cu ...... 1248 μg/L P ...... 214 mg/L U ...... 120 ng/L Dy ...... 13 ng/L Pb ...... 336 μg/L V ...... 5.9 μg/L Er ...... 10 ng/L Pd ...... < 10 ng/L W ...... 0.158 μg/L Eu ...... 11 ng/L Pr ...... 25 ng/L Y ...... 123 ng/L F (*) ...... 100 μg/L Pt ...... 6 ng/L Yb ...... 10 ng/L Fe ...... 343 mg/L Rb ...... 1.44 mg/L Zn ...... 8406 μg/L Ga ...... 30 ng/L Re ...... 0.8 ng/L Zr ...... 731 ng/L Gd ...... 12 ng/L Rh ...... < 20 ng/L (*) added amount, not analyzed Hf ...... 10 ng/L Ru ...... < 50 ng/L

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Clinical applications

Code Product Unit SERO210305 Trace elements in whole blood, level 3 10 x 3 mL This reference material is produced from blood collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. It contains all normal constituents which ensures the control and test samples to be analysed under the same conditions. Certified values after reconstitution Ag ...... 245 ng/L Hg ...... 31.4 μg/L S ...... 1066 mg/L Al ...... 112 μg/L Ho ...... 2.9 ng/L Sb ...... 87.1 μg/L As ...... 30.9 μg/L I ...... 189 μg/L Sc ...... 47 ng/L Au ...... 8 ng/L Ir ...... < 0.2 ng/L Se ...... 419 μg/L B ...... 467 μg/L K ...... 1111 mg/L Si ...... 1 mg/L Ba ...... 559 μg/L La ...... 145 ng/L Sm ...... 25 ng/L Be ...... 12.4 μg/L Li ...... 1.7 μg/L Sn ...... 12.1 μg/L Bi ...... 10.5 μg/L Lu ...... 1 ng/L Sr...... 25 μg/L Br...... 667 μg/L Mg ...... 15.6 mg/L Ta ...... 4.1 ng/L Ca ...... 14.2 mg/L Mn ...... 49.7 μg/L Tb ...... 2.5 ng/L Cd ...... 12.3 μg/L Mo ...... 12.9 μg/L Te ...... 0.065 μg/L Ce ...... 149 ng/L Na ...... 1437 mg/L Th ...... 13 ng/L Cs ...... 2.9 μg/L Nb ...... 91 ng/L Ti ...... 23 μg/L Co ...... 11.3 μg/L Nd ...... 106 ng/L Tl ...... 30.9 μg/L Cr ...... 37.3 μg/L Ni ...... 30.6 μg/L Tm ...... 1.5 ng/L Cu ...... 2401 μg/L P ...... 216 mg/L U...... 135 ng/L Dy ...... 14 ng/L Pb ...... 638 μg/L V ...... 13 μg/L Er...... 10 ng/L Pd ...... < 10 ng/L W ...... 0.205 μg/L Eu ...... 12 ng/L Pr ...... 29 ng/L Y ...... 117 ng/L F (*) ...... 200 μg/L Pt ...... 7 ng/L Yb ...... 12 ng/L Fe ...... 343 mg/L Rb ...... 1.5 mg/L Zn ...... 9381μg/L Ga ...... 28 ng/L Re ...... 0.9 ng/L Zr ...... 738 ng/L Gd ...... 14 ng/L Rh ...... < 20 ng/L (*) added amount, not analyzed Hf...... 9.5 ng/L Ru ...... < 50 ng/L

SERO201405 Trace elements in serum, level 1 6 x 3 mL This reference material is produced from serum collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. Contains all normal constituents which ensure the control and test samples to be analysed under the same conditions. Certified values after reconstitution Al ...... 33.6 μg/L Hg ...... 0.62 μg/L Sc ...... 7.6 ng/L Ag ...... 0.16 μg/L Ho ...... 1.9 ng/L Se ...... 107 μg/L As ...... 0.47 μg/L I ...... 84 μg/L Si ...... 0.74 mg/L Au ...... 540 μg/L Ir ...... 1.2 ng/L Sm ...... 7.7 ng/L B ...... 154 μg/L K ...... 126 mg/L Sn ...... 0.52 μg/L Ba ...... 126 μg/L La ...... 39.5 ng/L Sr...... 26.3 μg/L Be ...... 1.8 ng/L Li ...... 5741 μg/L Ta ...... 3.1 ng/L Bi ...... 3.7 ng Lu ...... 0.7 ng/L Te ...... 29 ng/L Br...... 488 μg/L Mn ...... 15 μg/L Tb ...... 1.3 ng/L Ca ...... 94.2 mg/L Mg ...... 20.1 mg/L Th ...... 2.9 ng/L Cd ...... 0.126 μg/L Mo ...... 0.7 μg/L Ti ...... 11.2 μg/L Ce ...... 38.7 ng/L Na ...... 2998 mg/L Tl ...... 23 ng/L Cr ...... 1.5 μg/L Nb ...... 40 ng/L Tm ...... 0.9 ng/L Cs ...... 18.6 ng/L Nd ...... 22.8 ng/L U...... 48 ng/L Co ...... 1.2 μg/L Ni ...... 5.8 μg/L V ...... 0.96 μg/L Cu ...... 1691 μg/L P ...... 70 mg/L W ...... 91 ng/L Dy ...... 3.5 ng/L Pb ...... 1.02 μg/L Y ...... 19 ng/L Er...... 3.5 ng/L Pr ...... 7.4 ng/L Yb ...... 2.5 ng/L F (*) ...... 75 μg/L Pt ...... 6.9 ng/L Zn ...... 1738 μg/L Fe ...... 1.39 mg/L Rb ...... 5.25 μg/L Zr ...... 278 ng/L Ga ...... 8.9 ng/L Re ...... 1.7 ng/L (*) added amount, not analyzed Gd ...... 5.2 ng/L S ...... 1448 mg/L Hf...... 5.7 ng/L Sb ...... 80 μg/L

36 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Clinical applications

Code Product Unit SERO203105 Trace elements in serum, level 2 6 x 3 mL This reference material is produced from serum collected from thoroughly controlled voluntary blood donors of a Scandinavian blood bank. Each unit is separately controlled and found negative for HBS antigen and HIV I, II and hepatitis C antibodies. No preservatives are added to the samples. Contains all normal constituents which ensure the control and test samples to be analysed under the same conditions. Certified values after reconstitution Al ...... 111 μg/L Ge ...... < 400 ng/L Ru ...... < 15 ng/L Ag ...... 343 ng/L Hf ...... 33 ng/L S ...... 1330 mg/L Ar ...... 343 ng/L Hg ...... 1.86 μg/L Sb ...... 21 μg/l As ...... < 1 μg/L Ho ...... 9 ng/L Sc ...... 57 ng/L Au ...... 1956 μg/L I...... 54 μg/L Se ...... 136 μg/L B ...... 41 μg/L Ir ...... 1.2 ng/L Si ...... 2.1 mg/L Ba ...... 271 μg/L K ...... 236 mg/L Sm...... 45 ng/L Be ...... 18 ng/L La ...... 315 ng/L Sn ...... 2.86 μg/L Bi ...... 21 ng Li ...... 10.6 mg/L Sr ...... 130 μg/L Br ...... 656 μg/L Lu ...... 3.4 ng/L Ta ...... 3.2 ng/L Ca ...... 117 mg/L Mn ...... 19.1 μg/L Tb ...... 5.4 ng/L Cd ...... 317 ng/L Mg ...... 28.9 mg/L Te ...... 19 ng/L Ce ...... 285 ng/L Mo ...... 1.31 μg/L Th ...... 45 ng/L Cr ...... 5.2 μg/L Na ...... 3783 mg/L Ti ...... 3.0 μg/L Cs ...... 22 ng/L Nb ...... 42 ng/L Tl ...... 34 ng/L Co ...... 3.2 μg/L Nd ...... 249 ng/L Tm ...... 3.1 ng/L Cu ...... 2.6 mg/L Ni ...... 10.7 μg/L U ...... 0.98 μg/L Dy ...... 30 ng/L P ...... 42 mg/L V ...... 1.12 μg/L Er ...... 20 ng/L Pb ...... 3 μg/L W ...... 84 ng/L Eu ...... 12 ng/L Pd ...... < 10 ng/L Y ...... 243 ng/L F (added amount) ...... 200 μg/L Pr ...... 69 ng/L Yb ...... 21 ng/L Fe ...... 1.91 mg/L Pt ...... 17 ng/L Zn ...... 0.92 mg/L Ga ...... 46 ng/L Rb ...... 7.2 μg/L Zr ...... 2.4 μg/L Gd ...... 41 ng/L Re ...... 6.3 ng/L

Blood cell size reference material BCR-165 Latex spheres, nominal 2 μ vial Average particle diameter ...... 2.223 ± 0.013 μm Each vial contains 2 mL of an aqueous suspension of latex spheres at a mass concentration of about 0.2 g/L About 0.5% of the particles are agglomerated doublets..

BCR-166 Latex spheres, nominal 4.8 μ vial Each vial contains 2 mL of an aqueous suspension of latex spheres at a mass concentration of about 0.2 g/L. About 0.5% of the particles are agglomerated doublets. Average particle diameter ...... 4.821 ± 0.019 μm

BCR-167 Latex spheres, nominal 9.6 μ vial Each vial contains 2 mL of an aqueous suspension of latex spheres at a mass concentration of about 1.4 g/L. About 0.5% of the particles are agglomerated doublets. Average particle diameter ...... 9.475 ± 0.018 μm

Edition 2011/2012 A wide variety of substances for Therapeutic Drug Monitoring available on request! 37

Clinical applications

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38 A wide variety of substances for Therapeutic Drug Monitoring available on request! Edition 2011/2012

Ethanol Reference Standards 3008 - A4 - advert.eps 1 26/08/2011 16:39:14

Reference Materials and Proficiency Testing Schemes

Reference materials, calibrators and controls

• Certified reference standards, solutions and powders • Therapeutic drugs and metabolites • Drugs of abuse • ‘Legal highs’ and ‘research chemicals’ • Matrix materials: blank, incurred and spiked

Heathcontrol Proficiency Testing Schemes

• Therapeutic Drug Monitoring including antiepileptics (traditional and new), immunosuppressants (ASI scheme), antibiotics, psychoactives, methotrexate and others

• Toxicology including ethanol paracetamol, salicylates, carboxyhaemoglobin, case studies and quantitative exercises

• Drugs of Abuse in urine and oral fluid

LGC Standards - the one stop shop for quality

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Forensic applications – Alcohol Ethanol reference materials LGC Standards has assembled an unrivalled offering of alcohol reference materials and related products; from primary reference standards to matrix matched materials. Correct use of these materials gives laboratories confidence in the analytical data they produce and report.

Primary reference materials These materials are directly traceable to the SI and have a low underlying uncertainty value. They are intended for the validation and calibration of analytical methodologies and verification of existing processes.

Code Product Unit ERM-AC409 Aqueous ethanol - 20mg / 100 ml 50 mL Ethanol mass concentration ...... 19.9 mg / 100 mL

ERM-AC510 Aqueous Ethanol - 50mg/100mL 25 mL Ethanol mass concentration ...... 49.6 mg / 100 mL

ERM-AC511 Aqueous Ethanol - 67mg/100mL 25 mL Ethanol mass concentration ...... 66.9 mg / 100 mL

ERM-AC401 Aqueous ethanol 80mg/dL 25ml 25 mL Ethanol mass concentration ...... 79.6 mg / 100mL

ERM-AC402 Aqueous ethanol - 107 mg / 100ml 25 mL Ethanol mass concentration ...... 106.5 mg / 100 mL

ERM-AC403 Aqueous ethanol - 200 mg / 100 ml 25 mL Ethanol mass concentration ...... 199.6 mg / 100mg

ERM-AC404 Ethanol/water - 5% Ethanol 50 mL Certified value Ethanol ...... 4.96 mL/100 mL at 20°C Density ...... 990.05 kg/m3 at 20°C

ERM-AC405 Ethanol/water - 15% Ethanol 50 mL Certified value Ethanol ...... 14.99 mL/100mL at 200C Density ...... 977.94 kg/m3 at 200C

ERM-AC406 Ethanol/water - 40% Ethanol 50 mL Certified value Ethanol ...... 40.04 mL/100 mL at 20°C Density ...... 946.91 kg/m3 at 20°C

ERM-AC407 Ethanol/water - 70% Ethanol 50 mL Certified value Ethanol ...... 69.98 mL/100mL at 200C Density ...... 884.55 kg/m3 at 200C ABV:alcohol by volume

NIST-2891 Ethanol-water solution unit (5) (nominal 0.02 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.02 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.01951 ± 0.00018 %

NIST-2892 Ethanol-water solution unit (5) (nominal 0.04 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.04 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.03900 ± 0.00046 %

NIST-2893 Ethanol-water solution unit (5) (nominal 0.08 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.08 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.08023 ± 0.00074 %

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Forensic applications – Alcohol

Code Product Unit NIST-2894 Ethanol-water solution unit (5) (nominal 0.1 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.1 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.10084 ± 0.00083 %

NIST-2895 Ethanol-water solution unit (5) (nominal 0.2 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.2 % mass fraction. This material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.1701 ± 0.0014 %

NIST-2896 Ethanol-water solution unit (5) (nominal 0.3 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 0.3 % mass fraction.The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in blood. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 0.2980 ± 0.0030 %

NIST-2897 Ethanol-water solution unit (5) (nominal 2 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 2 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in breath. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 1.554 ± 0.016 %

NIST-2898 Ethanol-water solution unit (5) (nominal 6 % mass fraction) This reference material is a solution of ethanol in water at a nominal level of 6 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in breath. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution Certified value Ethanol ...... 6.040 ± 0.043 %

NIST-2899 Ethanol-water solution unit (5) (nominal 25 % mass fraction) .This reference material is a solution of ethanol in water at a nominal level of 25 % mass fraction. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in breath. A unit consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified value Ethanol ...... 25.21 ± 0.22 %

NIST-1847 Ethanol-water solutions (breath-alcohol testing: three levels) unit (6) This reference material is a set of three levels of ethanol in water. The material is intended primarily for use in the calibration of instruments and techniques used for the determination of ethanol in breath. A unit consists of six ampoules, two ampoules each of the nominal levels (mass fraction) of 2 %, 6 %, and 25 %, each containing approximately 10 mL of solution. Nominal and certified levels (mass fraction) 2 % ...... 1.554 ± 0.016 % 6 % ...... 6.040 ± 0.043 % 25 % ...... 25.21 ± 0.22 %

Secondary reference materials These secondary reference materials are traceable to the SI through the use of Primary Reference Materials in their preparation. They are suitable for the development and validation of new analytical methodologies, for verification of existing processes and for routine use as control materials.

CERE-056 Ethanol-20 10 x 1.2 mL 20 mg/dL - 1.2 mL water / ampoule CERE-040 Ethanol-10 10 x 1.2 mL 10 mg/dL - 1.2 mL water / ampoule CERE-042 Ethanol-15 5 x 5 mL 15 mg/dL - 5 mL water / ampoule CERE-043 Ethanol-20 5 x 5 mL 20 mg/dL - 5 mL water / ampoule CERE-035 Ethanol-25 10 x 1.2 mL 25 mg/dL - 1.2 mL water / ampoule

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Forensic applications – Alcohol

Code Product Unit CERE-045 Ethanol-40 10 x 1.2 mL 40 mg/dL - 1.2 mL water / ampoule CERE-029 Ethanol-50 10 x 1.2 mL 50 mg/dL - 1.2 mL water / ampoule CERE-030 Ethanol-80 10 x 1.2 mL 80 mg/dL - 1.2 mL water / ampoule CERE-037 Ethanol-80 5 x 5 mL 80 mg/dL - 5 mL water / ampoule CERE-031 Ethanol-100 10 x 1.2 mL 100 mg/dL - 1.2 mL water / ampoule CERE-038 Ethanol-100 5 x 5 mL 100 mg/dL - 5 mL water / ampoule CERE-041 Ethanol-150 10 x 1.2 mL 150 mg/dL - 1.2 mL water / ampoule CERE-032 Ethanol-200 10 x 1.2 mL 200 mg/dL - 1.2 mL water / ampoule CERE-039 Ethanol-200 5 x 5 mL 200 mg/dL - 5 mL water / ampoule CERE-033 Ethanol-300 10 x 1.2 mL 300 mg/dL - 1.2 mL water / ampoule CERE-036 Ethanol-400 10 x 1.2 mL 400 mg/dL - 1.2 mL water / ampoule CERE-044 Ethanol-400 5 x 5 mL 400 mg/dL - 5 mL water / ampoule CERE-053 Ethanol-500 10 x 1.2 mL 500 mg/dL - 1.2 mL water / ampoule CERE-034 Ethanol calibration kit 10 x 1.2 mL 2 ampoules of each of the individual standards. Ethanol at stated concentration (mg/dL), 1.2 mL/ampoule 10 ampoules per kit Ethanol-50 mg/dL ...... CERE-029 Ethanol-80 mg/dL ...... CERE-030 Ethanol-100 mg/dL ...... CERE-031 Ethanol-200 mg/dL ...... CERE-032 Ethanol-300 mg/dL ...... CERE-033

CERA-076 Multi-component alcohol mix 100 μg/mL 1.2 mL 4 components in water, 100 μg/mL of each component: acetone, isopropanol, ethanol, methanol

CERA-057 Multi-component alcohol mix 500 μg/mL 1.2 mL 4 components in water, 500 μg/mL of each component: acetone, isopropanol, ethanol, methanol

CERA-056 Multi-component alcohol mix 1000 μg/mL 1.2 mL 4 components in water, 1000 μg/mL of each component: acetone, isopropanol, ethanol, methanol

CERA-061 Multi-component alcohol mix 4000 μg/mL 1.2 mL 4 components in water, 4000 μg/mL of each component: acetone, isopropanol, ethanol, methanol

CERA-054 Multi-component alcohol calibration kit 3 x 1.2 mL Prepared as congener alcohols in water. It contains three ampoules each of three different concentration levels. Analytes level 1 level 2 level 3 μg/mL μg/mL μg/mL Acetone ...... 500 ...... 1000 ...... 4000 Methanol ...... 500 ...... 1000 ...... 4000 Ethanol ...... 500 ...... 1000 ...... 4000 Isopropanol ...... 500 ...... 1000 ...... 4000

Working reference materials ACQ SCIENCE and Medichem have produced a range of aqueous and matrix-matched materials for the analysis of ethanol in serum and blood. These materials have been characterized through collaborative exercises and trials, and are ideal for routine use as control materials to allow effective monitoring of an assay’s performance.

ME 20010 Aqueous ethanol standard (0.1 g/L) 10 x 1.1 mL (Medidrug Ethanol W)

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Forensic applications – Alcohol

Code Product Unit ME 20011 Aqueous ethanol standard (0.1 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20013 Aqueous ethanol standard (0.1 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20020 Aqueous ethanol standard (0.2 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20021 Aqueous ethanol standard (0.2 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20023 Aqueous ethanol standard (0.2 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20030 Aqueous ethanol standard (0.3 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20031 Aqueous ethanol standard (0.3 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20033 Aqueous ethanol standard (0.3 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20051 Aqueous ethanol standard (0.5 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20050 Aqueous ethanol standard (0.5 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20053 Aqueous ethanol standard (0.5 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20081 Aqueous ethanol standard (0.8 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20080 Aqueous ethanol standard (0.8 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20083 Aqueous ethanol standard (0.8 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20101 Aqueous ethanol standard (1.0 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20100 Aqueous ethanol standard (1.0 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20103 Aqueous ethanol standard (1.0 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20111 Aqueous ethanol standard (1.1 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20110 Aqueous ethanol standard (1.1 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20113 Aqueous ethanol standard (1.1 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20131 Aqueous ethanol standard (1.3 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20130 Aqueous ethanol standard (1.3 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20133 Aqueous ethanol standard (1.3 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20151 Aqueous ethanol standard (1.5 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20150 Aqueous ethanol standard (1.5 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20153 Aqueous ethanol standard (1.5 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20201 Aqueous ethanol standard (2.0 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20200 Aqueous ethanol standard (2.0 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20203 Aqueous ethanol standard (2.0 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20301 Aqueous ethanol standard (3.0 g/L) 100 x 1.1 mL (Medidrug Ethanol W)

44 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Forensic applications – Alcohol

Code Product Unit ME 20300 Aqueous ethanol standard (3.0 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20303 Aqueous ethanol standard (3.0 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20401 Aqueous ethanol standard (4.0 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20400 Aqueous ethanol standard (4.0 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20403 Aqueous ethanol standard (4.0 g/L) 10 x 3 mL (Medidrug Ethanol W) ME 20500 Aqueous ethanol standard (5.0 g/L) 10 x 1.1 mL (Medidrug Ethanol W) ME 20501 Aqueous ethanol standard (5.0 g/L) 100 x 1.1 mL (Medidrug Ethanol W) ME 20503 Aqueous ethanol standard (5.0 g/L) 10 x 3 mL (Medidrug Ethanol W) AC-AQ01-015 Aqueous ethanol control EtOH AQ (0.1 g/L) 10 x 1.5 mL AC-AQ01-030 Aqueous ethanol control EtOH AQ (0.1 g/L) 10 x 3.0 ml AC-AQ02-015 Aqueous ethanol control EtOH AQ (0.2 g/L) 10 x 1.5 mL AC-AQ02-030 Aqueous ethanol control EtOH AQ (0.2 g/L) 10 x 3.0 ml AC-AQ03-015 Aqueous ethanol control EtOH AQ (0.3 g/L) 10 x 1.5 mL AC-AQ03-030 Aqueous ethanol control EtOH AQ (0.3 g/L) 10 x 3.0 ml AC-AQ05-015 Aqueous ethanol control EtOH AQ (0.5 g/L) 10 x 1.5 mL AC-AQ05-030 Aqueous ethanol control EtOH AQ (0.5 g/L) 10 x 3.0 ml AC-AQ08-015 Aqueous ethanol control EtOH AQ (0.8 g/L) 10 x 1.5 mL AC-AQ08-030 Aqueous ethanol control EtOH AQ (0.8 g/L) 10 x 3.0 ml AC-AQ10-015 Aqueous ethanol control EtOH AQ (1.0 g/L) 10 x 1.5 mL AC-AQ10-030 Aqueous ethanol control EtOH AQ (1.0 g/L) 10 x 3.0 ml AC-AQ11-015 Aqueous ethanol control EtOH AQ (1.1 g/L) 10 x 1.5 mL AC-AQ11-030 Aqueous ethanol control EtOH AQ (1.1 g/L) 10 x 3.0 ml AC-AQ13-015 Aqueous ethanol control EtOH AQ (1.3 g/L) 10 x 1.5 mL AC-AQ13-030 Aqueous ethanol control EtOH AQ (1.3 g/L) 10 x 3.0 ml AC-AQ15-015 Aqueous ethanol control EtOH AQ (1.5 g/L) 10 x 1.5 mL AC-AQ15-030 Aqueous ethanol control EtOH AQ (1.5 g/L) 10 x 3.0 ml AC-AQ20-015 Aqueous ethanol control EtOH AQ (2.0 g/L) 10 x 1.5 mL AC-AQ20-030 Aqueous ethanol control EtOH AQ (2.0 g/L) 10 x 3.0 ml AC-AQ30-015 Aqueous ethanol control EtOH AQ (3.0 g/L) 10 x 1.5 mL AC-AQ30-030 Aqueous ethanol control EtOH AQ (3.0 g/L) 10 x 3.0 ml AC-AQ40-015 Aqueous ethanol control EtOH AQ (4.0 g/L) 10 x 1.5 mL AC-AQ40-030 Aqueous ethanol control EtOH AQ (4.0 g/L) 10 x 3.0 ml AC-AQ50-015 Aqueous ethanol control EtOH AQ (5.0 g/L) 10 x 1.5 mL AC-AQ50-030 Aqueous ethanol control EtOH AQ (5.0 g/L) 10 x 3.0 ml Alcohol congeners in water ME 91311 Aqueous congener alcohols control, level 1 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 0.5 mg/L 2-Methyl-1-butanol...... 0.1 mg/L Methanol ...... 1.0 mg/L 3-Methyl-1-butanol...... 0.1 mg/L 1-Butanol ...... 0.1 mg/L 1-Propanol ...... 0.1 mg/L 2-Butanol ...... 0.1 mg/L 2-Propanol ...... 0.1 mg/L 2-Butanon ...... 0.1 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.1 mg/L

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Forensic applications – Alcohol

Code Product Unit ME 91321 Aqueous congener alcohols control, level 2 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 1.0 mg/L 2-Methyl-1-butanol ...... 0.2 mg/L Methanol ...... 2.0 mg/L 3-Methyl-1-butanol ...... 0.2 mg/L 1-Butanol ...... 0.2 mg/L 1-Propanol ...... 0.2 mg/L 2-Butanol ...... 0.2 mg/L 2-Propanol ...... 0.2 mg/L 2-Butanon ...... 0.2 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.2 mg/L

ME 91331 Aqueous congener alcohols control, level 3 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 1.5 mg/L 2-Methyl-1-butanol ...... 0.3 mg/L Methanol ...... 3.0 mg/L 3-Methyl-1-butanol ...... 0.3 mg/L 1-Butanol ...... 0.3 mg/L 1-Propanol ...... 0.33mg/L 2-Butanol ...... 0.3 mg/L 2-Propanol ...... 0.4 mg/L 2-Butanon ...... 0.3 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.3 mg/L

ME 91341 Aqueous congener alcohols control, level 4 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 2.0 mg/L 2-Methyl-1-butanol ...... 0.4 mg/L Methanol ...... 4.0 mg/L 3-Methyl-1-butanol ...... 0.4 mg/L 1-Butanol ...... 0.4 mg/L 1-Propanol ...... 0.4 mg/L 2-Butanol ...... 0.4 mg/L 2-Propanol ...... 0.4 mg/L 2-Butanon ...... 0.4 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.4 mg/L

ME 91351 Aqueous congener alcohols control, level 5 10 x 1.2 mL Aquous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 2.5 mg/L 2-Methyl-1-butanol ...... 0.5 mg/L Methanol ...... 5.0 mg/L 3-Methyl-1-butanol ...... 0.5 mg/L 1-Butanol ...... 0.5 mg/L 1-Propanol ...... 0.5 mg/L 2-Butanol ...... 0.5 mg/L 2-Propanol ...... 0.5 mg/L 2-Butanon ...... 0.5 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.5 mg/L

ME 91361 Aqueous congener alcohols control, level 6 10 x 1.2 mL Aqeuous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 5.0 mg/L 2-Methyl-1-butanol ...... 1.0 mg/L Methanol ...... 10.0 mg/L 3-Methyl-1-butanol ...... 1.0 mg/L 1-Butanol ...... 1.0 mg/L 1-Propanol ...... 1.0 mg/L 2-Butanol ...... 1.0 mg/L 2-Propanol ...... 1.0 mg/L 2-Butanon ...... 1.0 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 1.0 mg/L

ME 91371 Aqueous congener alcohols control, level 7 10 x 1.2 mL Aqeuous congener alsochols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 10.0 mg/L 2-Methyl-1-butanol ...... 2.0 mg/L Methanol ...... 20.0 mg/L 3-Methyl-1-butanol ...... 2.0 mg/L 1-Butanol ...... 2.0 mg/L 1-Propanol ...... 2.0 mg/L 2-Butanol ...... 2.0 mg/L 2-Propanol ...... 2.0 mg/L 2-Butanon ...... 2.0 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 2.0 mg/L

Ethanol in serum ME 11010 Ethanol in human serum with reference values (0.1 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11012 Ethanol in human serum with reference values (0.1 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11013 Ethanol in human serum with reference values (0.1 g/L) 10 x 3 mL (Medidrug Ethanol S-plus)

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Forensic applications – Alcohol

Code Product Unit ME 11020 Ethanol in human serum with reference values (0.2 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11022 Ethanol in human serum with reference values (0.2 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11023 Ethanol in human serum with reference values (0.2 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11030 Ethanol in human serum with reference values (0.3 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11032 Ethanol in human serum with reference values (0.3 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11033 Ethanol in human serum with reference values (0.3 g/L) 10 x 3 mL (Medidrug Ethanol S-plus)

ME 11050 Ethanol in human serum with reference values (0.5 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11052 Ethanol in human serum with reference values (0.5 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11053 Ethanol in human serum with reference values (0.5 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11080 Ethanol in human serum with reference values (0.8 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11082 Ethanol in human serum with reference values (0.8 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11083 Ethanol in human serum with reference values (0.8 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11100 Ethanol in human serum with reference values (1.0 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11102 Ethanol in human serum with reference values (1.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11103 Ethanol in human serum with reference values (1.0 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11110 Ethanol in human serum with reference values (1.1 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11112 Ethanol in human serum with reference values (1.1 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11113 Ethanol in human serum with reference values (1.1 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11130 Ethanol in human serum with reference values (1.3 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11132 Ethanol in human serum with reference values (1.3 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11133 Ethanol in human serum with reference values (1.3 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11150 Ethanol in human serum with reference values (1.5 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11152 Ethanol in human serum with reference values (1.5 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11153 Ethanol in human serum with reference values (1.5 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11200 Ethanol in human serum with reference values (2.0 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11202 Ethanol in human serum with reference values (2.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11203 Ethanol in human serum with reference values (2.0 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11300 Ethanol in human serum with reference values (3.0 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11302 Ethanol in human serum with reference values (3.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11303 Ethanol in human serum with reference values (3.0 g/L) 10 x 3 mL (Medidrug Ethanol S-plus)

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Forensic applications – Alcohol

Code Product Unit ME 11400 Ethanol in human serum with reference values (4.0 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11402 Ethanol in human serum with reference values (4.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11403 Ethanol in human serum with reference values (4.0 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 11500 Ethanol in human serum with reference values (5.0 g/L) 10 x 1.1 mL (Medidrug Ethanol S-plus) ME 11502 Ethanol in human serum with reference values (5.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-plus) ME 11503 Ethanol in human serum with reference values (5.0 g/L) 10 x 3 mL (Medidrug Ethanol S-plus) ME 12012 Ethanol in human serum, precision control, X1 (0.5 - 0.6 g/L) 10 x 1.5 mL (Medidrug Ethanol S-X) ME 12013 Ethanol in human serum, precision control, X1 (0.5 - 0.6 g/L) 10 x 3 mL (Medidrug Ethanol S-X) ME 12022 Ethanol in human serum, precision control, X2 (0.8 - 1.1 g/L) 10 x 1.5 mL (Medidrug Ethanol S-X) ME 12023 Ethanol in human serum, precision control, X2 (0.8 - 1.1 g/L) 10 x 3 mL (Medidrug Ethanol S-X) ME 12032 Ethanol in human serum, precision control, X3 (2.0 - 3.0 g/L) 10 x 1.5 mL (Medidrug Ethanol S-X) ME 12033 Ethanol in human serum, precision control, X3 (2.0 - 3.0 g/L) 10 x 3 mL (Medidrug Ethanol S-X) AC-SE01-015 Ethanol in serum control EtOH SE (0.1 g/L) 10 x 1.5 mL AC-SE01-030 Ethanol in serum control EtOH SE (0.1 g/L) 10 x 3 mL AC-SE02-015 Ethanol in serum control EtOH SE (0.2 g/L) 10 x 1.5 mL AC-SE02-030 Ethanol in serum control EtOH SE (0.2 g/L) 10 x 3 mL AC-SE03-015 Ethanol in serum control EtOH SE (0.3 g/L) 10 x 1.5 mL AC-SE03-030 Ethanol in serum control EtOH SE (0.3 g/L) 10 x 3 mL AC-SE05-015 Ethanol in serum control EtOH SE (0.5 g/L) 10 x 1.5 mL AC-SE05-030 Ethanol in serum control EtOH SE (0.5 g/L) 10 x 3 mL AC-SE08-015 Ethanol in serum control EtOH SE (0.8 g/L) 10 x 1.5 mL AC-SE08-030 Ethanol in serum control EtOH SE (0.8 g/L) 10 x 3 mL AC-SE10-015 Ethanol in serum control EtOH SE (1.0 g/L) 10 x 1.5 mL AC-SE10-030 Ethanol in serum control EtOH SE (1.0 g/L) 10 x 3 mL AC-SE11-015 Ethanol in serum control EtOH SE (1.1 g/L) 10 x 1.5 mL AC-SE11-030 Ethanol in serum control EtOH SE (1.1 g/L) 10 x 3 mL AC-SE13-015 Ethanol in serum control EtOH SE (1.3 g/L) 10 x 1.5 mL AC-SE13-030 Ethanol in serum control EtOH SE (1.3 g/L) 10 x 3 mL AC-SE15-015 Ethanol in serum control EtOH SE (1.5 g/L) 10 x 1.5 mL AC-SE15-030 Ethanol in serum control EtOH SE (1.5 g/L) 10 x 3 mL AC-SE20-015 Ethanol in serum control EtOH SE (2.0 g/L) 10 x 1.5 mL AC-SE20-030 Ethanol in serum control EtOH SE (2.0 g/L) 10 x 3 mL AC-SE30-015 Ethanol in serum control EtOH SE (3.0 g/L) 10 x 1.5 mL AC-SE30-030 Ethanol in serum control EtOH SE (3.0 g/L) 10 x 3 mL AC-SE40-015 Ethanol in serum control EtOH SE (4.0 g/L) 10 x 1.5 mL AC-SE40-030 Ethanol in serum control EtOH SE (4.0 g/L) 10 x 3 mL AC-SE50-015 Ethanol in serum control EtOH SE (5.0 g/L) 10 x 1.5 mL AC-SE50-030 Ethanol in serum control EtOH SE (5.0 g/L) 10 x 3 mL

48 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Forensic applications – Alcohol

Code Product Unit Alcohol congeners in serum ME 91111 Congener alcohols in human serum, level 1 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 0.5 mg/L 2-Methyl-1-butanol...... 0.1 mg/L Methanol ...... 1 mg/L 3-Methyl-1-butanol...... 0.1 mg/L 1-Butanol ...... 0.1 mg/L 1-Propanol ...... 0.1 mg/L 2-Butanol ...... 0.1 mg/L 2-Propanol ...... 0.1 mg/L 2-Butanon ...... 0.1 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.1 mg/L

ME 91121 Congener alcohols in human serum, level 2 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 1 mg/L 2-Methyl-1-butanol...... 0.2 mg/L Methanol ...... 2 mg/L 3-Methyl-1-butanol...... 0.2 mg/L 1-Butanol ...... 0.2 mg/L 1-Propanol ...... 0.2 mg/L 2-Butanol ...... 0.2 mg/L 2-Propanol ...... 0.2 mg/L 2-Butanon ...... 0.2 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.2 mg/L

ME 91131 Congener alcohols in human serum, level 3 10 x 1.2 mL Aqueous congener alcohols control (Medidrug BGS W) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 1.5 mg/L 2-Methyl-1-butanol...... 0.3 mg/L Methanol ...... 3 mg/L 3-Methyl-1-butanol...... 0.3 mg/L 1-Butanol ...... 0.3 mg/L 1-Propanol ...... 0.3 mg/L 2-Butanol ...... 0.3 mg/L 2-Propanol ...... 0.3 mg/L 2-Butanon ...... 0.3 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.3 mg/L

ME 91141 Congener alcohols in human serum, level 4 10 x 1.2 mL Serum control (Medidrug BGS S) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 2.0 mg/L 2-Methyl-1-butanol...... 0.4 mg/L Methanol ...... 4.0 mg/L 3-Methyl-1-butanol...... 0.4 mg/L 1-Butanol ...... 0.4 mg/L 1-Propanol ...... 0.4 mg/L 2-Butanol ...... 0.4 mg/L 2-Propanol ...... 0.4 mg/L 2-Butanon ...... 0.4 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.4 mg/L

ME 91151 Congener alcohols in human serum, level 5 10 x 1.2 mL Serum control (Medidrug BGS S) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 2.5 mg/L 2-Methyl-1-butanol...... 0.5 mg/L Methanol ...... 5.0 mg/L 3-Methyl-1-butanol...... 0.5 mg/L 1-Butanol ...... 0.5 mg/L 1-Propanol ...... 0.5 mg/L 2-Butanol ...... 0.5 mg/L 2-Propanol ...... 0.5 mg/L 2-Butanon ...... 0.5 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 0.5 mg/L

ME 91161 Congener alcohols in human serum, level 6 10 x 1.2 mL Serum control (Medidrug BGS S) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 5.0 mg/L 2-Methyl-1-butanol...... 1.0 mg/L Methanol ...... 10.0 mg/L 3-Methyl-1-butanol...... 1.0 mg/L 1-Butanol ...... 1.0 mg/L 1-Propanol ...... 1.0 mg/L 2-Butanol ...... 1.0 mg/L 2-Propanol ...... 1.0 mg/L 2-Butanon ...... 1.0 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 1.0 mg/L

ME 91171 Congener alcohols in human serum, level 7 10 x 1.2 mL Serum control (Medidrug BGS S) for quality control of quantitative determinations of congener alcohols by GC. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Acetone ...... 10.0 mg/L 2-Methyl-1-butanol...... 2.0 mg/L Methanol ...... 20.0 mg/L 3-Methyl-1-butanol...... 2.0 mg/L 1-Butanol ...... 2.0 mg/L 1-Propanol ...... 2.0 mg/L 2-Butanol ...... 2.0 mg/L 2-Propanol ...... 2.0 mg/L 2-Butanon ...... 2.0 mg/L Ethanol ...... 1.5 g/L Isobutanol ...... 2.0 mg/L

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Markers for identification of ethanol use

Code Product Unit Ethanol in blood ME 61050 Ethanol in human whole blood, 0.5 g/L 10 x 1.1ml (Medidrug Ethanol VB-plus) ME 61052 Ethanol in human whole blood, 0.5 g/L 10 x 1,5 ml (Medidrug Ethanol VB-plus) ME 61053 Ethanol in human whole blood, 0.5 g/L 10 x 3 mL (Medidrug Ethanol VB-plus) ME 61080 Ethanol in human whole blood, 0.8 g/L 10 x 1.1 mL (Medidrug Ethanol VB-plus) ME 61082 Ethanol in human whole blood, 0.8 g/L 10 x 1.5 mL (Medidrug Ethanol VB-plus) ME 61083 Ethanol in human whole blood, 0.8 g/L 10 x 3 mL (Medidrug Ethanol VB-plus) ME 61110 Ethanol in human whole blood, 1.1 g/L 10 x 1.1 mL (Medidrug Ethanol VB-plus) ME 61112 Ethanol in human whole blood, 1.1 g/L 10 x 1.5 mL (Medidrug Ethanol VB-plus) ME 61113 Ethanol in human whole blood, 1.1 g/L 10 x 3 mL (Medidrug Ethanol VB-plus) AC-WH03-015 Ethanol in whole blood control EtOH WH (0.3 g/L) 10 x 1.5 mL AC-WH03-030 Ethanol in whole blood control EtOH WH (0.3 g/L) 10 x 3 mL AC-WH05-015 Ethanol in whole blood control EtOH WH (0.5 g/L) 10 x 1.5 mL AC-WH05-030 Ethanol in whole blood control EtOH WH (0.5 g/L) 10 x 3 mL AC-WH08-015 Ethanol in whole blood control EtOH WH (0.8 g/L) 10 x 1.5 mL AC-WH08-030 Ethanol in whole blood control EtOH WH (0.8 g/L) 10 x 3 mL AC-WH11-015 Ethanol in whole blood control EtOH WH (1.1 g/L) 10 x 1.5 mL AC-WH11-030 Ethanol in whole blood control EtOH WH (1.1 g/L) 10 x 3 mL AC-WH20-015 Ethanol in whole blood control EtOH WH (2.0 g/L) 10 x 1.5 mL AC-WH20-030 Ethanol in whole blood control EtOH WH (2.0 g/L) 10 x 3 mL

Markers for identification of ethanol use

Code Product Unit ME 70002 Ethyl-beta-D-6-glucuronide 2 mg ME 70010 Ethyl-beta-D-6-glucuronide 10 mg CERE-016 Ethyl beta-D-glucuronide (0.1 mg/mL) 1 mL in Methanol ME 70502 Ethyl-beta-D-6-glucuronide-D5 2 mg ME 70510 Ethyl-beta-D-6-glucuronide-D5 10 mg CERE-048 Ethyl beta-D-glucuronide-D5 (0.1 mg/mL) 1 mL in Methanol LA 30-1400-1 Ethyl myristate 1 g LA 30-1801-1 Ethyl oleate 1 g LA 30-1600-1 Ethyl palmitate 1 g LA 30-1800-1 Ethyl stearate 1 g TRC-E925182 Ethyl myristate-ethyl-D5 10 mg TRC-E925327 Ethyl oleate-ethyl-D5 10 mg TRC-E925482 Ethyl palmitate-ethyl-D5 10 mg TRC-E925952 Ethyl stearate-ethyl-D5 10 mg ATH0902-10 Ethyl sulfate, sodium salt 10 mg ATH0902D-10 Ethyl sulfate-D5, sodium salt 10 mg REC-21080 Serum control for CDT (carbohydrate deficient transferin) 10 x 1 mL lyophilised - level I REC-21081 Serum control for CDT (carbohydrate deficient transferiin) 10 x 1 mL lyophilised - level II

50 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Markers for identification of ethanol use

Code Product Unit REC-21082 Serum control for CDT (carbohydrate deficient transferiin) 2 x 5 x 1ml lyophilised - level I and II REC-21014 CDT (carbohydrate deficient transferrin) - test solution 15 mL ME 41057 Ethylglucuronide in human serum 10 x 2.5 mL (Medidrug ETG 1/06-A S-plus) Lyophilised serum control prepared from human serum for accuracy and precision monitoring of ethylglucuronide determinations in serum. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethylglucuronide ...... 3.64 mg/L

AC-SE015.010.001 Ethylglucuronide in serum ETG 3/10-A SE, lyophilised 10 x 2.5 mL for in vitro diagnostic use Analytes Target value Ethylglucuronide ...... 0,64 mg/L Ethylsulfate ...... 0,91mg/L

ME 41079 Ethylglucuronide, human urine control with reference values 10 x 2.5 mL (Medidrug ETG 1/08-B U-plus) Lyophilised serum control prepared from human urine for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in urine. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 0.350 mg/L

ME 41080 Ethylglucuronide, human urine control with reference values 10 x 2.5 mL (Medidrug ETG 2/09-B U-plus) Lyophilised serum control prepared from human urine for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in urine. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 3.020 mg/L Ethyl sulfate ...... 1.750 mg/L

AC-UR015.010.001 Ethylglucuronide in urine ETG 3/10-B UR, lyophilised 10 x 2.5 mL for in vitro diagnostic use Analytes Target value Ethylglucuronide ...... 1,27 mg/L Ethylsulfate ...... 0,81mg/L

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 51

Markers for identification of ethanol use

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52 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Forensic applications – pure materials New “Legal High” and “Bath Salt” Certiﬁed Reference Materials

LGC Standards has an active programme of producing new Certiﬁed Reference Materials of novel psychoactive materials for use in Forensic and Clinical Laboratories.

• 5-APB and 6-APB • AM-694 • Butylone • Desoxypipradrol • Diclofensine • Dimethocaine • DMAA • 4-Fluoroamphetamine • MDPV • MDAI • MDAT • 5-MeO-DALT • Methedrone • Methiopropamine • Methylone • Naphyrone • Phenazepam

Many of these highly characterised materials are unique to LGC Standards. These reference materials give organisations conﬁdence in the analytical data they produce to identify or quantify seized samples or toxicology specimens.

www.lgcstandards.com

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No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or any retrieval system, without the written permission of the copyright holder. © LGC Limited, 2011. All rights reserved. 3041/SS/0811

Powder materials produced by LGC Standards

Code Product Unit LGCFOR1275.71 AB-001 (Adamantyl(1-pentylindol-3-yl)methanone) 10 mg O

LGCFOR1275.28 4-Acetoxy-N,N-diisopropyltryptamine Hydrochloride (4-AcO-DIPT 10 mg O HCl, 4-Acetoxy-DIPT HCl, Ipracetin HCl) N O x HCl

N H O OH LGCFOR1275.29 4-Acetoxy-N-methyl-N-ethyltryptamine Fumarate (4-AcO-MET N 10 mg O Fumarate, 4-Acetoxy-MET Fumarate) O x

O N HO H LGCFOR0133.00 Acetylsalicylic Acid O 10 mg OH

O LGCFOR0061.00 Aciclovir O 10 mg N HN OH N H2N N O OH LGCFOR0614.02 L-Adrenaline H 10 mg HO N

HO LGCFOR1275.17 AM-694 (1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole) O I 10 mg

LGCFOR0028.03 2-Amino-5-chlorobenzophenone NH2 10 mg O Cl

LGCFOR0071.01 2-Amino-2',5-dichlorobenzophenone NH2 10 mg O Cl Cl

LGCFOR0171.01 N-(2-Aminoethyl)-2-(benzylphenylamino)acetamide 10 mg Dihydrochloride O x 2 HCl N NH2 N H LGCFOR1275.50 2-Aminoindane Hydrochloride (2-AI HCl) 10 mg NH2 x HCl

H O LGCFOR0078.07 7-Aminonitrazepam N 10 mg

H2N N

LGCFOR0078.01 2-Amino-5-nitrobenzophenone NH2 10 mg O O2N

LGCFOR0062.00 Amitriptyline HCl 10 mg

N x HCl

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 57

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0565.00 Androstanolone (5alpha-Dihydrotestosterone, Stanolone) OH 10 mg

O H LGCFOR0323.01 Androstenedione O 10 mg

O LGCFOR0007.04 2-Anhydrotramadol Hydrochloride (2-(3-Methoxyphenyl)-N,N-dimethyl- O 10 mg 2-cyclohexene-1-methanamine Hydrochloride) x HCl N

LGCFOR1275.24 5-APB HCl (1-Benzofuran-5-ylpropan-2-amine Hydrochloride, NH2 10 mg x HCl 5-(2-Aminopropyl)benzofuran Hydrochloride) O LGCFOR1275.23 6-APB HCl (1-Benzofuran-6-ylpropan-2-amine Hydrochloride, O NH2 10 mg x HCl 6-(2-Aminopropyl)benzofuran Hydrochloride)

LGCFOR0562.00 Apomorphine HCl OH 10 mg HO x HCl x 1/2 H2O N H

LGCFOR0467.00 Aprindine Hydrochloride N 10 mg

N x HCl

OH LGCFOR0013.00 Atenolol H 10 mg O N O

H2N LGCFOR0289.18 Atropine H 10 mg O H N O

OH H and enantiomer H LGCFOR0289.00 Atropine sulphate O 10 mg H x H2SO4 N O x H2O and enantiomer OH H 2

H LGCFOR0265.03 Barbituric Acid O N O 10 mg

O LGCFOR0456.00 Benzbromarone O 10 mg Br O OH Br

O LGCFOR1275.36 Benzedrone Hydrochloride (4-Methyl-N-benzylcathinone H 10 mg Hydrochloride) N x HCl

LGCFOR0490.02 Benzhydrol (Diphenylmethanol) 10 mg

LGCFOR0094.00 Benzocaine O 10 mg O

H2N

OH OH LGCFOR0460.08 Bisoprolol Fumarate H 10 mg O N O x

O O O 2 HO LGCFOR0864.00 Boldenone OH 10 mg

H O LGCFOR0064.00 Bromazepam N 10 mg

Br N

58 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0060.00 Brompheniramine maleate O 100 mg N OH x OH N O Br

O H LGCFOR1275.19 Buphedrone N 10 mg

O LGCFOR1275.32 Buphedrone Hydrochloride H 10 mg N x HCl

O LGCFOR0745.00 Bupropion HCl H 10 mg Cl N x HCl

O H LGCFOR1275.03 Butylone Hydrochloride N 10 mg O x HCl

O LGCFOR0494.00 Caffeine O 10 mg N N

O N N

LGCFOR0076.00 Carbamazepine O 10 mg

N NH2

LGCFOR0076.01 Carbamazepine 10,11-Epoxide O 10 mg

N NH2

O LGCFOR0128.00 Celiprolol Hydrochloride OH 10 mg H O N O x HCl N N H

O LGCFOR0380.13 Cetirizine N-Oxide O 10 mg Cl O N OH N

LGCFOR0038.00 Clobutinol Hydrochloride 10 mg N x HCl OH Cl Cl LGCFOR0017.00 Chlormezanone OO 10 mg S

O LGCFOR1275.16 ortho-Chlorophenylpiperazine Hydrochloride (oCPP HCl) NH 10 mg N x HCl

Cl OH LGCFOR0380.01 1-[(4-Chlorophenyl)phenylmethyl]piperazine N 10 mg N

x 2 HCl

Cl OH LGCFOR0380.11 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol N 10 mg Dihydrochloride N x 2 HCl

LGCFOR0071.04 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid O 10 mg N OH N Cl Cl

H LGCFOR0071.09 6-Chloro-4-(2-chlorophenyl)-2(1H)-quinazolinone N O 10 mg

N Cl Cl

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 59

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0090.00 Chlorphenamine Maleate Cl 10 mg O

OH x N OH N O LGCFOR0420.00 Chlorpromazine Hydrochloride 10 mg N N x HCl S

Cl LGCFOR0420.01 Chlorpromazine Sulphoxide 10 mg

N N S O

Cl LGCFOR0242.00 Citalopram HBr F 10 mg x HBr

N O

N LGCFOR0545.00 Clomipramine HCl Cl 10 mg

N N x HCl

Cl LGCFOR0983.00 Clonidine Hydrochloride HN 10 mg x HCl N N H Cl LGCFOR0015.01 (2-Chlorophenyl)diphenylmethanol 10 mg

Cl HO

LGCFOR0480.00 Clozapine Cl N 10 mg N N

LGCFOR0682.00 Cloxacillin Sodium Monohydrate Cl O 10 mg ONa O N N H x H2O O N S H O

LGCFOR0442.00 Codeine phosphate hemihydrate N 10 mg

x H3PO4 x 1/2 H2O

O O OH LGCFOR1083.00 Colchicine O 10 mg NH O O O O O LGCFOR0214.00 Cortisone O 10 mg OH O OH

O LGCFOR0517.03 Cotinine 10 mg N N O

LGCFOR0185.08 11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) O 10 mg OH OH

60 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0068.05 Desacetyldiltiazem O 10 mg

S OH N O

H O LGCFOR0070.02 Desalkylflurazepam (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H- N 10 mg 1,4-benzodiazepin-2-one) Cl N

LGCFOR0764.02 Desethylhydroxychloroquine Dihydrochloride Cl N 10 mg x 2 HCl

HN OH N H LGCFOR0422.01 Deshydroxyethylopipramol Dihydrochloride (5-(3-Piperazin-1-yl- 10 mg

propyl)-5H-dibenzo[b,f]azepine Dihydrochloride) N x 2 HCl

N NH LGCFOR0589.00 Desipramine Hydrochloride 10 mg

N N x HCl H

LGCFOR0060.16 Desmethylbrompheniramine Maleate O 10 mg N OH x OH N H O Br LGCFOR0090.13 Desmethylchlorphenamine Maleate Cl 10 mg O

OH x OH N NH O

LGCFOR0242.09 Desmethylcitalopram Hydrochloride F 10 mg

x HCl

N O H

N LGCFOR0545.08 Desmethylclomipramine HCl Cl 10 mg

N N x HCl H

LGCFOR0480.03 Desmethylclozapine (Norclozapine) Cl NH 10 mg N N

H LGCFOR0033.10 N-Desmethyldextromethorphan Hydrochloride (ent- N 10 mg 3-Methoxymorphinan Hydrochloride) x HCl

LGCFOR0033.09 O-Desmethyldextromethorphan Hydrochloride N 10 mg (ent-17-Methylmorphinan-3-ol (L)-Tartrate) OH O HO x OH O OH

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Powder materials produced by LGC Standards

Code Product Unit LGCFOR0068.03 N-Desmethyldiltiazem HCl O 10 mg

S O x HCl N O O

H O LGCFOR0069.02 Desmethylflunitrazepam N 10 mg

O2N N

LGCFOR0019.07 N-Desmethyllevomepromazine Hydrochloride 10 mg

N N H x HCl S

O LGCFOR0991.02 Desmethylsibutramine Hydrochloride 10 mg x HCl

HN Cl LGCFOR0254.08 Desmethylsildenafil (1-[[3-(4,7-Dihydro-1-methyl-7-oxo- O 10 mg 3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)- HN N O O N 4-ethoxyphenyl]sulfonyl]piperazine) S N N HN O

LGCFOR0051.07 O-Desmethylsulpiride O O 10 mg O S N N H2N H OH

LGCFOR0007.06 O-Desmethyltramadol HCl HO 10 mg OH x HCl N

and enantiomer LGCFOR0240.02 Desmethyltrimipramine HCl 10 mg

N N H x HCl

LGCFOR0393.04 N-Desmethylvenlafaxine Hydrochloride 10 mg OH

H x HCl N

O LGCFOR0393.01 O-Desmethylvenlafaxine 10 mg OH

HO LGCFOR1275.22 Desoxypipradrol Hydrochloride (2-DPMP HCl) 10 mg

N H x HCl

LGCFOR0528.04 N-Phenyl-1-(2-phenylethyl)piperidin-4-amine 10 mg

LGCFOR0033.00 Dextromethorphan HBr N 10 mg

x HBr x H2O

O LGCFOR0651.00 Prasterone (DHEA, Dehydroepiandrosterone) O 10 mg

62 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

O LGCFOR0435.02 Diacetolol Hydrochloride OH 10 mg H O N O

N H

O LGCFOR0023.00 Diazepam [Controlled Substance] N 10 mg

Cl N

LGCFOR0006.00 Diclofenac Sodium ONa 10 mg O NH Cl Cl

LGCFOR1275.18 Diclofensine Hydrochloride N 10 mg

Cl x HCl

O Cl LGCFOR0991.03 Didesmethylsibutramine Hydrochloride 10 mg x HCl

NH2 Cl

LGCFOR0007.08 N,O-Didesmethyltramadol Hydrochloride HO 10 mg OH x HCl N H

and enantiomer LGCFOR0212.00 Digoxin O O 10 mg OH

OH OO H

OO OH

OO OH HO OH LGCFOR0068.00 Diltiazem HCl O 10 mg

S O N O O

x HCl N

LGCFOR0599.00 Dimenhydrinate O 10 mg H N N x Cl N O O N N

LGCFOR1275.08 Dimethocaine Hydrochloride O 10 mg O N

H2N

LGCFOR1275.12 Dimethylamylamine Hydrochloride (4-Methyl-2-hexanamine NH2 10 mg x HCl Hydrochloride, DMAA HCl) LGCFOR1275.30 Dimethylcathinone Hydrochloride (N,N-Dimethylcathinone O 10 mg N Hydrochloride, Metamfepramone Hydrochloride) x HCl

O LGCFOR1275.42 3,4-Dimethylmethcathinone Hydrochloride (3,4-DMMC HCl) H 10 mg N x HCl

LGCFOR0490.00 Diphenhydramine HCl 10 mg

x HCl N O

LGCFOR0490.01 Diphenhydramine N-Oxide 10 mg

O N O

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 63

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0557.00 Diphenylpyraline HCl 10 mg O x HCl N

O LGCFOR0107.00 Domperidone NH 10 mg N HN Cl N N

LGCFOR0510.00 Dosulepin HCl (Dothiepin) N 10 mg

x HCl

LGCFOR0032.00 Doxepin Hydrochloride N 10 mg

x HCl O

LGCFOR0101.00 Doxylamine Hydrogen Succinate O 10 mg

OH N N x O OH

O LGCFOR1294.00 Dronedarone Hydrochloride O 10 mg

O N x HCl NH O S O OH LGCFOR1122.00 Duloxetine Hydrochloride H 10 mg N x HCl

OH LGCFOR0652.00 Ephedrine Hydrochloride DRUG PRECURSOR H 10 mg N x HCl

LGCFOR1147.00 Ephedrine Sulphate OH 10 mg H N x H2SO4

2 LGCFOR0323.03 Epitestosterone OH 10 mg

O LGCFOR0300.00 Estradiol Hemihydrate OH 10 mg

x 1/2 H2O

HO LGCFOR0130.00 Estriol OH 10 mg

HO LGCFOR0282.00 Estrone O 10 mg

HO LGCFOR0750.00 Ethosuximide H 10 mg O N O

O LGCFOR1275.63 beta-Ethylmethcathinone Hydrochloride H 10 mg N x HCl

H LGCFOR0608.00 Fenfluramine Hydrochloride N 10 mg x HCl

F F F

64 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0528.00 Fentanyl 10 mg

O N

O LGCFOR1275.33 Flephedrone Hydrochloride (4-Fluoromethcathinone Hydrochloride) H 10 mg N x HCl

F H LGCFOR0256.00 Fluoxetine HCl O N 10 mg

F x HCl F F

LGCFOR0069.00 Flunitrazepam O 10 mg N

O2N N

LGCFOR0741.02 4-Fluoroamphetamine HCl NH2 10 mg x HCl F O LGCFOR1275.64 2-Fluoromethcathinone Hydrochloride (1-(2-Fluorophenyl)- H 10 mg N 2-(methylamino)propan-1-one Hydrochloride) x HCl

F O LGCFOR1275.43 3-Fluoromethcathinone Hydrochloride (1-(3-Fluorophenyl)- H 10 mg F N 2-(methylamino)propan-1-one Hydrochloride) x HCl

LGCFOR1275.13 4-Fluorotropacocaine (3-Pseudotropyl 4-Fluorobenzoate, 3beta-(p- H 10 mg O H Fluorobenzoyloxy)tropane) N O

F H LGCFOR0114.00 Fluphenazine Dihydrochloride 10 mg

N N S N x 2 HCl OH F

F F LGCFOR0959.00 Fluoxymesterone OH 10 mg HO

F O LGCFOR0014.00 Furosemide OOH 10 mg H N O

H2N S O O Cl

LGCFOR0582.00 Griseofulvin Cl O 10 mg O O O

O O LGCFOR1275.51 Gammabutyrolactone (GBL) O 10 mg

LGCFOR1275.49 Hordenine Hydrochloride (4-Hydroxy-N,N- 10 mg N dimethylphenethylamine Hydrochloride) x HCl

HO LGCFOR0011.00 Hydrochlorothiazide O O O O 10 mg S S H2N NH

Cl N H LGCFOR0185.00 Hydrocortisone (Cortisol) O 10 mg OH HO OH

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Powder materials produced by LGC Standards

Code Product Unit LGCFOR0062.05 10-Hydroxyamitriptyline 10 mg N

HO LGCFOR0764.00 Hydroxychloroquine sulphate Cl N 10 mg x H2SO4

HN OH N

LGCFOR0076.10 10-Hydroxy-10,11-dihydrocarbamazepine Cl N 10 mg x H2SO4

HN OH N

LGCFOR0077.04 10-Hydroxyimipramine BH3-Aduct 10 mg

N N x BH3

OH LGCFOR0491.03 9-Hydroxyrisperidone N 10 mg

N F N O

Cl O LGCFOR0852.00 Hydroxyzine Hydrochloride N OH 10 mg N x 2 HCl

LGCFOR0002.00 Ibuprofen 10 mg OH

O LGCFOR0076.06 Iminodibenzyl (10,11-Dihydro-5H-dibenzo[b,f]azepine) 10 mg

LGCFOR0077.00 Imipramine Hydrochloride 10 mg

N N x HCl

LGCFOR0077.12 Imipramine N-Oxide 10 mg

N N O

LGCFOR1275.78 5-Iodo-2-aminoindane (5-IAI) Hydrochloride NH2 x HCl 10 mg I LGCFOR1275.72 JWH-015 ((2-Methyl-1-propylindol-3-yl)(naphthalen-1-yl)methanone) 10 mg

LGCFOR1275.66 JWH-122 ((4-Methylnaphthalen-1-yl)(1-pentylindol-3-yl)methanone) 10 mg

LGCFOR1275.70 JWH-203 (2-(2-Chlorophenyl)-1-(1-pentylindol-3-yl)ethanone) 10 mg

O Cl

O LGCFOR0144.00 Ketamine HCl Cl 10 mg NH x HCl

66 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0180.04 Ketotifen S N 10 mg

LGCFOR0180.00 Ketotifen Hydrogen Fumarate S N 10 mg

N NH2 LGCFOR0922.00 Lamotrigine N 10 mg N

NH2 Cl Cl

O Cl O LGCFOR1035.00 Levocetirizine Dihydrochloride N OH 10 mg N

x 2 HCl

LGCFOR0019.00 Levomepromazine Maleate O 10 mg N N OH x S OH

O O LGCFOR0019.01 Levomepromazine Sulphoxide 10 mg

N N S O

O O LGCFOR0257.00 Loratadine Cl 10 mg N O

LGCFOR0102.00 Lidocaine H 10 mg N N O

H O LGCFOR0071.00 Lorazepam N 10 mg OH Cl N

LGCFOR0820.00 Maprotiline Hydrochloride 10 mg

N H x HCl

LGCFOR1275.80 MDAT HCl (6,7-Methylenedioxy-2-aminotetralin Hydrochloride) O NH2 10 mg x HCl O LGCFOR0056.04 Melamine H2NNHN 2 10 mg NN

NH2 LGCFOR0052.00 Metamizole Sodium Monohydrate O O O 10 mg NS ONa N x H2O N

LGCFOR0056.00 Metformin Hydrochloride NH NH 10 mg x HCl H2NNN H

H LGCFOR0964.00 Methamphetamine HCl N 10 mg x HCl

O LGCFOR1275.04 Methedrone Hydrochloride H 10 mg N x HCl

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 67

Powder materials produced by LGC Standards

Code Product Unit LGCFOR1275.07 5-MeO-DALT (5-Methoxy-N,N-diallyltryptamine) 10 mg N

N H OH LGCFOR0027.00 Metoprolol Tartrate H 10 mg O N

O 2 OH O x HO OH O OH

LGCFOR1275.65 Methoxetamine Hydrochloride O 10 mg NH O x HCl

LGCFOR1247.02 1-(2-Methoxyphenyl)piperazine Dihydrochloride 10 mg x 2 HCl N HN O

LGCFOR0051.05 2-Methoxy-5-sulphamoylbenzamide O O 10 mg H2N S NH O 2 O LGCFOR1275.62 4'-Methyl-alpha-pyrrolidinobutiophenone Hydrochloride (MPBP HCl) O 10 mg N x HCl

LGCFOR1275.41 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane HN 10 mg Hydrochloride O x HCl

LGCFOR0586.07 N-(3-Methylbenzyl)piperazine DiHCl N 10 mg x 2 HCl HN LGCFOR1275.44 2-Methyl-2-butanol 10 mg OH LGCFOR1275.61 3',4'-Methylenedioxy-alpha-pyrrolidinobutiophenone Hydrochloride O 10 mg (MDPBP HCl) O N x HCl

O LGCFOR1275.05 5,6-Methylenedioxy-2-aminoindane (MDAI) O 10 mg NH2 O

LGCFOR1275.60 3,4-Methylenedioxy-N-benzylcathinone Hydrochloride O 10 mg H O N x HCl

O O LGCFOR1275.20 Methylethcathinone Hydrochloride (4-Methyl-N- H 10 mg N ethylcathinone Hydrochloride, 4-MEC HCl) x HCl

LGCFOR1005.01 4-Methyl-1-(3-methylpyridin-2-yl)-2-phenylpiperazine 10 mg

N N

O LGCFOR1275.01 Methylone Hydrochloride H 10 mg N O x HCl

O H LGCFOR1275.54 N-Methyl-2-phenylethylamine Hydrochloride (N-Methyl-PEA HCl) N 10 mg x HCl

LGCFOR1280.01 1-Methyl-4-(phenylmethyl)piperazine HCl N 10 mg x HCl N LGCFOR1005.07 1-Methyl-3-phenylpiperazine 10 mg

N HN

68 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0147.00 Mianserin HCl N 10 mg N x HCl

O LGCFOR0147.06 Mianserin N-Oxide N 10 mg N

LGCFOR0250.00 Moclobemide O O 10 mg N N H Cl LGCFOR0267.00 Molsidomine O 10 mg O O N - N N+ N O

LGCFOR0037.00 Morphine HCl trihydrate [Controlled Substance] N 10 mg

x HCl x 3 H2O

HO O OH

LGCFOR0280.00 Morphine hemisulphate pentahemihydrate [Controlled Substance] N 10 mg

x H2SO4 x 5 H2O

HO O OH 2

LGCFOR1001.06 Mycophenolic Acid O OH 10 mg OH O O O

LGCFOR0272.00 Naloxone Hydrochloride Dihydrate N 10 mg x HCl HO x 2 H2O

HO O O

LGCFOR0233.00 Naltrexone Hydrochloride N 10 mg

HO x HCl

HO O O LGCFOR0660.00 Nandrolone OH 10 mg

O LGCFOR1275.06 Naphyrone Hydrochloride (1-Naphthalen-2-yl-2-pyrrolidin- O 10 mg 1-ylpentan-1-one Hydrochloride) N x HCl

LGCFOR1275.35 1-Naphyrone Hydrochloride (1-Naphthalen-1-yl-2-pyrrolidin-1-ylpentan- 10 mg N O 1-one Hydrochloride) x HCl

LGCFOR0152.00 Naproxen 10 mg OH

O O LGCFOR0517.00 Nicotine 10 mg N N

H O LGCFOR0078.00 Nitrazepam [Controlled Substance] N 10 mg

O2N N

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 69

Powder materials produced by LGC Standards

Code Product Unit LGCFOR0660.01 Norandrostenedione (19-Norandrost-4-ene-3,17-dione) O 10 mg

O LGCFOR0004.05 Norcodeine [Controlled Substance] HN 10 mg

O O OH H O LGCFOR0023.02 Nordazepam [Controlled Substance] N 10 mg

Cl N

LGCFOR0490.03 Nordiphenhydramine Hydrochloride 10 mg

H x HCl N O

LGCFOR0059.06 Norpheniramine Maleate N O 10 mg H N OH x OH

H O LGCFOR0091.03 Nortetrazepam N 10 mg

Cl N

LGCFOR0079.00 Nortriptyline Hydrochloride 10 mg

N H x HCl

LGCFOR0608.01 Norfenfluramine Hydrochloride NH2 10 mg

x HCl F F F H LGCFOR0672.03 Noroxycodone Hydrochloride N 10 mg

HO x HCl

O O O LGCFOR0095.00 Omeprazole 10 mg O NH O N S O N

H O LGCFOR0080.00 Oxazepam N 10 mg OH Cl N

LGCFOR0076.17 Oxcarbazepine O 10 mg

N NH2

O LGCFOR0957.00 Oxomemazine 10 mg N

S O O OH LGCFOR0129.00 Oxprenolol Hydrochloride H 10 mg O N x HCl

70 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0672.00 Oxycodone HCl N 10 mg

HO x HCl

O O O LGCFOR0099.01 Pantoprazole 10 mg O NNa O F O F N S O N LGCFOR0099.00 Pantoprazole sodium 10 mg O NNa O F O F N S O N LGCFOR0042.00 Paracetamol 10 mg O NH O F O F N S O N O LGCFOR1275.57 Pentylone Hydrochloride H 10 mg O N x HCl O

LGCFOR0815.00 Perazine dimaleate N O 10 mg N HO x 2 N HO

O S

LGCFOR0157.01 Perazine Sulphoxide N 10 mg N

S O LGCFOR0826.00 Perphenazine 10 mg N N S N OH

Cl LGCFOR0826.01 Perphenazine Sulphoxide 10 mg

N N S N O OH

Cl H LGCFOR0551.00 Phenacetin N 10 mg

O O H O LGCFOR0828.00 Phenazepam N 10 mg

Br N

LGCFOR1275.47 2-Phenylethylamine Hydrochloride NH2 10 mg x HCl (Phenethylamine Hydrochloride, PEA HCl)

LGCFOR0548.00 Phenylbutazone O 10 mg

N N

LGCFOR0656.00 Phenylpropanolamine Hydrochloride (D,L-Norephedrine OH 10 mg NH Hydrochloride) 2 x HCl

and enantiomer

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 71

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0528.08 N-Phenyl-N-(piperidin-4-yl)propanamide O NH 10 mg

LGCFOR0770.00 Phenyltoloxamine Citrate O 10 mg OH N O OH x O

OH OH O LGCFOR0630.00 Phenytoin 10 mg H N O

LGCFOR0539.07 Piperazine Hexahydrate NH 10 mg x 6 H2O HN

O LGCFOR1275.46 1-Piperonylpiperazine N 10 mg NH O

LGCFOR0596.00 Procaine Hydrochloride O 10 mg N O x HCl

H2N LGCFOR0222.00 Progesterone O 10 mg

O LGCFOR0290.00 Promazine HCl 10 mg N

N x HCl

S LGCFOR0290.01 Promazine Sulphoxide 10 mg N

S O LGCFOR0412.00 Promethazine HCl 10 mg N N x HCl S

LGCFOR0412.04 Promethazine Sulphoxide 10 mg N N S O

LGCFOR0043.00 Propranolol Hydrochloride OH 10 mg H O N x HCl

LGCFOR2115.00 (+)-Pseudoephedrine HCl (DRUG PRECURSOR) OH 10 mg NH x HCl

H H LGCFOR0086.00 Ranitidine Hydrochloride O N N 10 mg N S x HCl

NO2 LGCFOR0542.00 Ribavirin O 10 mg

H2N N HO N N O

OH OH LGCFOR0491.00 Risperidone N 10 mg N F N O

72 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit LGCFOR1031.04 Ritalinic Acid O OH 10 mg H N

OH LGCFOR0381.00 Salbutamol Sulphate H 10 mg N

x H2SO4 HO

OH 2 LGCFOR0045.00 Salicylic Acid O 10 mg OH

LGCFOR0317.00 Sertraline HN 10 mg

Cl Cl LGCFOR0317.01 Sertraline HCl HN 10 mg

x HCl

Cl Cl LGCFOR0254.09 Sildenafil O 10 mg HN N O O N S N N N O LGCFOR0254.00 Sildenafil citrate O O 10 mg N HO O O O HN N x S HO N N HO OH N O O LGCFOR0254.04 Sildenafil N-Oxide O 10 mg HN N O O N S N N O N O

LGCFOR0051.00 Sulpiride O O 10 mg O S N N H2N H O LGCFOR0323.00 Testosterone OH 10 mg

O LGCFOR0493.00 Testosterone Benzoate O 10 mg O

O LGCFOR0863.00 Testosterone Isocaproate O 10 mg O

O LGCFOR0897.00 Testosterone Propionate O 10 mg O

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 73

Powder materials produced by LGC Standards

Code Product Unit O LGCFOR0091.00 Tetrazepam N 10 mg

Cl N

LGCFOR0703.00 Tetramisole Hydrochloride N S 10 mg x HCl N

H LGCFOR1275.59 1-(Thiophen-2-yl)-2-methylaminopropane Hydrochloride S N 10 mg (Methiopropamine Hydrochloride, MPA HCl) x HCl

LGCFOR0134.05 Tilidine N 10 mg

O O and enantiomer

LGCFOR0134.00 Tilidine HCl hemihydrate N 10 mg

x HCl x 1/2 H2O

O O and enantiomer LGCFOR0577.00 Theobromine O 10 mg N HN

O N N

LGCFOR0176.00 Theophylline O 10 mg H N N

O N N

LGCFOR0007.00 Tramadol HCl O 10 mg OH x HCl N

and enantiomer

LGCFOR0007.11 Tramadol N-Oxide O 10 mg OH

N O

and enantiomer LGCFOR0421.00 Trazodone HCl 10 mg N N Cl N x HCl N N

O LGCFOR0306.00 Triamcinolone Hexacetonide O 10 mg O O

HO O O

F O LGCFOR0958.00 Trimeprazine Tartrate 10 mg N OH O x HO N OH O OH S 2

LGCFOR0240.00 Trimipramine maleate O 10 mg

OH N N x OH

LGCFOR0601.03 Tropic Acid O 10 mg

OH LGCFOR0393.00 Venlafaxine HCl 10 mg OH x HCl N

74 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Powder materials produced by LGC Standards

Code Product Unit

LGCFOR0022.00 Verapamil Hydrochloride O 10 mg O x HCl O

N O LGCFOR0149.00 Zopiclone Cl 10 mg N O N N N N

O N LGCFOR0149.01 Zopiclone Oxide O 10 mg Cl N O O N N N N

O N

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 75

Powder materials produced by LGC Standards

Just send an e-mail to [email protected]

76 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Forensic applications – pure materials and solutions A partnership for forensic science standards

Alcohol standards • Ethanol standards with various concentrations • Multi-component alcohol and alcohol congeners calibration kits

Drugs, including metabolites, impurities and deuterated forms • Anti-depressants • Benzodiazepines • Cannabinoids • Hallucinogens • Opiates • Steroids • Stimulants • Tranquillizers ...and many more

Other materials for forensic interest • Explosives • NSAIDs • Derivatising reagents ...and many more

© LGC Standards 2011, 1872/SR/0508 www.lgcstandards.com T-068 T-068 FE021811-01 FE021811-01 Revision 1 Revision 1 Page 2 of 6 Page 1 of 6 Certificate of Analysis Standard Solution Assay Parameters Calibration Curve Analysis Method: UV/Vis Calibration Curve: Linear Regression Wavelength: 227 nm Number of Points: 4 Slit Width: 1.0 nm Linearity(r) : 1.000 Tilidine HCl Response: 0.5 s

HCl Catalog Number: T-068 . H3C CH3 Neat Material Data Solution Lot: FE021811-01 N O Retest Date: April 2012 Compound Name: Tilidine HCl Chemical Formula: C17H23NO2 OCH Solvent: Methanol 3 Compound Lot: PC012511-01 CAS Number: 27107-79-5 Volume per Ampule: Not less than 1 mL Molecular Weight: 309.83 Storage: Store in freezer. Intended Use: For R&D/ analytical purposes only. Not suitable for human or animal consumption. Regulatory: USDEA Exempt | Canadian TK # 61-620 Safety: Flammable, Poison Neat Material Characterization Summary Retest Date - stability studies ongoing. Certificate of Analysis will be updated upon completion of retest. Analytical Test Method Results Ampules are overfilled to ensure a minimum 1 mL volume fill. We advise laboratories to use measured volumes of this standard solution before diluting to the desired concentration. Primary Chromatographic Purity by HPLC/PDA Analysis SP10-0102 98.9%

Secondary Purity Analysis by Thin Layer Chromatography SP10-0106 Single Spot, Rf = 0.68 ComponentComponent ChromatographicChromatographic PurityPurity CertCertifiediffied ConcConcentrationentration Identityyy by LC/MS Analysis y SP10-0107 Consistent with Structure Tilidine HClHCl 98.9% 1.0001.000 ± 0.0060.0060 mg/mLmg/mL/mL ( (asasas free base base)) 1 Uncertainty of the concentration is expressed as an expanded uncertainty in accordance with ISO 17025 and Guide 34 at the approximate Identity by H-NMR Analysis USP <761>, SP10-0116 Consistent with Structure 95% confidence interval using a coverage factor of k = 2 and has been calculated by statistical analysis of our production system and Residual Solvent Analysis by GC/FID Headspace AM1087 1 None Detected incorporates uncertainty of the purity factor, material density, and balance and weighing technique. Concentration is corrected for chromatographic purity, residual water, residual solvents and residual inorganics. Residual Water Analysis by Karl Fischer Coulometry USP <921>, SP10-0103 2.73% Inorganic Content by Microash Analysis SP10-0135 < 0.2% Solution Standard Verification and Homogeneity Purity Factor 96.21% Standard Verified Concentration (mg/mL) %RSD - Homogeneity Solution Lot Number Actual Results Acceptance CrtieriaActual Results Acceptance Crtieria Primary purity is calculated as the average of two independently performed analyses utilizing two different methods. Acceptance criteria requires the purity values to be within 0.5% of each other. New Lot FE021811-01 0.999 ± 3% 0.3 ≤ 3% The primary chromatographic purity value is used to calculate the Purity Factor. Concentration is verified through multiple analyses and is calculated as the average of multiple analyses compared to an independently A secondary chromatographic purity method is utilized as a control. prepared calibration solution. Purity Factor = [(100 - wt% residual solvent - wt% residual water - wt% residual inorganics) x Chromatographic Purity/100]. Homogeneity of the New Lot is ensured through rigorous production process controls statistically analyzed to evaluate risk and verified by Purity factor does not include adjustment for chiral and/or isotopic purity. analysis. The % RSD of samples pulled from across the lot demonstrate homogeneity of the New Lot. 1 Validated analytical method Traceability Gravimetrically prepared using qualified balances calibrated semi-annually by Mettler Toledo using NIST traceable weights. Calibration verification performed weekly and prior to each use utilizing NIST traceable weights. Each balance has been assigned a minimum weighing by Mettler Toledo taking into consideration the balance and installed environmental conditions to ensure weighing complies with USP tolerances of no more than 0.1% relative error. Concentration is verified against an independently prepared calibration solution gravimetrically prepared using balances calibrated to NIST. In addition, each neat material utilized has been identified and thoroughly characterized through the use of multiple analytical techniques. Spectral data is provided on subsequent pages of the COA.

Cerilliant certifies that this standard meets the specifications stated in this certificate and warrants this product to meet the stated acceptance criteria through the expiration/retest date when stored unopened as recommended. Product should be used shortly after opening to avoid concentration changes due to evaporation. Warranty does not apply to ampoules stored after opening.

June 30, 2011 Lara Sparks, Quality Assurance Director Date

Cerilliant Corporation 811 Paloma Drive, Suite A, Round Rock, TX 78665 800-848-7837 / 512-238-9974 Cerilliant Corporation 811 Paloma Drive, Suite A, Round Rock, TX 78665 800-848-7837 / 512-238-9974

T-068 T-068 FE021811-01 FE021811-01 Revision 1 Revision 1 Page 3 of 6 Page 4 of 6 Spectral and Physical Data Spectral and Physical Data (cont.)

HPLC/PDA Residual Solvent Analysis by GC/FID Headspace DAD1 A, Sig=220,8 Ref=off (S:\HPLC\HPLC3\2011\LC30211\P0207107.D) Column: Betasil Phenyl, 4.6 x 150 mm FID1 A, (GC90211\D0207110.D) Column: DB-ALC1 30 m x 0.53 mm, 3 μm film thickness mAU Mobile Phase: Acetonitrile::10 mM Potassium phosphate buffer 70 6.954 Temp Program: 40°C (12 min) to 220°C at 40°C/min (5.5 min) (30::70) pA Carrier Gas: Helium Flow Rate: 1.0 mL/min 60 Wavelength: 220 nm Flow Rate: 2.0 mL/min 120 Detector Heater Temp: 250°C 50 Data File Name: S:\HPLC\HPLC3\2011\LC30211\P0207107.D Injector: Headspace Sampler Operator: TNT 100 HS Oven Temp: 60°C 40 Instrument: LC#3 Vial Equilibration: 10 minutes Sample Name: PC012511-01 80

30 Method File: PRM241-1.M Data File Name: C:\CHEM32\1\DATA\GC90211\D0207110.D Acquired: February 7, 2011 2:51 PM 60 Operator: BD

20 Instrument: GC#9 Peak # Ret Time Area Height Area % 40 Sample Name: PC012511-01

10 1 3.68 0.37 0.05 0.02 Acquired: February 7, 2011 4:16 PM 2 4.23 2.47 0.32 0.16 20 14.588 - NM - P 14.588 16.549 5.292 4.229 0 3.677 3 5.29 4.99 0.56 0.32 Peak Compound Area Weight % 4 6.95 1564.54 71.16 98.77 5 16.55 11.61 0.49 0.73 2.5 5 7.5 10 12.5 15 17.5 20 min 1 NMP NA NA 0 5 10 15 20 mi Total ND

ND - Not Detected 1 H NMR Instrument: JEOL ECS 400

Solvent: DMSO-D6

Cerilliant Corporation 811 Paloma Drive, Suite A, Round Rock, TX 78665 800-848-7837 / 512-238-9974 Cerilliant Corporation 811 Paloma Drive, Suite A, Round Rock, TX 78665 800-848-7837 / 512-238-9974 T-068 T-068 FE021811-01 FE021811-01 Revision 1 Revision 1 Page 5 of 6 Page 6 of 6 Spectral and Physical Data (cont.) Stability LC/MS Column: Luna 3μ C18, 2.0 x 100 mm Short Term Stability : A summary of accelerated stability findings for a related product (Nortilidine HCl) is listed Mobile Phase: Acetonitrile::0.1% Formic acid in Water below. (10::90 to 50::50 at 5 mins, hold 10 mins) Flow Rate: 0.3 mL/min Storage Condition Mean Kinetic Temperature (MKT) Time Period Scan Range: 100-1000 amu Freezer -15°C Ionization: Electrospray, Positive Ion Refrigerator 4°C No decrease in purity was noted after one month. Data File Name: A02071109.d Room Temperature 21°C Operator: HJ 40°C40°C Instrument: LC/MS/MS Transport/Shipping : Stability data supports transport of this product at MKT not exceeding 40 °C over a period of Sample Name: PC012511-01 Method File: 19-55C2P.M one month. Acquired: February 7, 2011 12:31 PM

COA Revision History

Revision No. Date Reason for Revision 00 3/2/2011 Initial version 01 6/30/2011 Revised Storage condition from "Refrigerate or freeze" to "Store in freezer."

National Measurement Institute Spectroscopic and other characterisation data GC-MS: Instrument: Agilent 6890/5973 REFERENCE MATERIAL ANALYSIS REPORT Column: TG-1MS, 30 m x 0.25 mm I.D. x 0.25 m Program: 60 C (1 min), 10 C/min to 100 C, 15 C/min to 250 C (5 min), 30 C/min Report ID: D964.2011.01 to 300 C (2 min) Compound Name: (±)-4’-Methyl-pyrrolidinopropiophenone hydrochloride Injector: 250 C Transfer line temp: 280 C Description: White solid Carrier: Helium, 1.0 mL/min Split ratio: 30/1 Collection Number: D964 Batch Number: 11-D-02 The retention time of the parent compound is reported with the major peaks in the mass spectra. Chemical Formula: C14H19NO.HCl Molecular Weight: 253.8 (salt), 217.3 (base) The latter are reported as mass/charge ratios and (in brackets) as a percentage relative to the base CAS Number: 28117-80-8 (base) Batch production completed: March 2011 peak. Structure: O Parent (12.7 min): 119 (9), 98 (100), 91 (8), 65 (4), 56 (8), 44 (8) m/z

CH3 ESI -MS: Instrument Micromass Quatro LC Micro .HCl Operation: Positive ion mode, direct infusion at 10 L/min N Ionisation: ESI spray voltage at 3.5 kV positive ion H C 3 EM voltage: 650 V Cone voltage 3 V + Synonyms: 1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-propanone hydrochloride Peak: 218.2 (M+H ) m/z 4’-Methyl-2-(1-pyrrolidinyl)-propiophenone hydrochloride HS-GC-MS: Instrument: Agilent 6890/5973/G1888 MPPP Column: DB-624, 30 m x 0.25 mm I.D. x 1.4 m Purity (mass fraction): 99.5 ± 2.9% (95% coverage interval) Program: 50 C (5 min), 7 C/min to 120 C, 15 °C/min to 220 °C (8.3 min) Injector: 150 C Transfer line temp: 280 C Purity estimate obtained from a combination of traditional analytical techniques and quantitative nuclear Carrier: Helium, 1.2 mL/min Split ratio: 50/1 magnetic resonance (QNMR). The purity estimate by traditional analytical techniques was obtained by Solvents detected: Diethyl ether, ethanol subtraction from 100% of total impurities by HPLC with UV detection, thermogravimetric analysis, Karl 1 Fischer analysis and H NMR analysis. The purity value obtained from quantitative nuclear magnetic resonance TLC: Conditions: Kieselgel 60F254. Methanol/NH3 (100/1.5) (QNMR) using a combination of the three proton doublet at 1.6 ppm and the one proton quartet at 5.2 ppm Single spot observed, Rf = 0.66. Visualisation with UV at 254 nm against a certified internal standard of maleic acid. Supporting evidence is provided by headspace GC-MS analysis of occluded solvents and elemental microanalysis. IR: Instrument: Biorad FTS3000MX FT-IR Range: 4000-400 cm-1, KBr powder HPLC: Instrument: Shimadzu Binary pump LC-20AB, SIL-20 A HT autosampler Peaks: 2955, 2640, 2579, 2447, 2361, 1686, 1606, 1457, 1388, 1339, Column: X-Bridge C-18, 5 m (4.6 mm x 150 mm) 1295, 1244, 1135, 978, 830, 736, 586 cm-1 Column oven: Ambient 1 Mobile Phase: Acetonitrile/MilliQ water (40:60) H NMR: Instrument: Bruker Avance DMX-600 The aqueous phase was buffered at pH 10.8 using 20mM NH OAc and Field strength: 600 MHz Solvent: D2O (4.79 ppm) 4 NH4OH Spectral data: 7.91 (2H, d, J = 8.3 Hz), 7.44 (2H, d, J = 8.1 Hz), 5.23 (1H, q, J = 7.1 Hz), Flow rate: 2.0 mL/min 2.80-4.10 (4H, m (br)), 2.44 (3H, s), 1.80-2.35 (4H, m (br)), 1.63 (3H, d, J = Detector: Shimadzu SPD-M20A operating at 225 nm 7.1 Hz) ppm Ethanol and diethyl ether, estimated at 0.08% mass fraction Retention time: 5.7 min were observed in the 1H NMR Relative peak area response of main component: 13 C NMR: Instrument: Bruker Avance DMX-600 Initial analysis: Mean = 99.3%, s = 0.04% (10 sub samples in duplicate, March 2011) Field strength: 151 MHz Solvent: D2O Thermogravimetric analysis: Non volatile residue < 0.2 % mass fraction (April 2011). The volatile Spectral data: 16.1, 21.0, 22.9, 52.2, 54.4, 65.4, 129.1, 129.8, 130.0, 147.6, 197.2 ppm content (e.g. organic solvents and/or water) could not be determined because o of the inherent volatility of the material. Melting point: 222-223 C Karl Fischer analysis: Moisture content 0.2% mass fraction (April 2011) Microanalysis: Found: C = 66.4%; H = 8.1%; N = 5.5%; Cl = 14.1% (April, 2011) Calc: C = 66.3%; H = 7.9%; N = 5.5%; Cl = 14.0% (Calculated for QNMR: Instrument: Bruker Avance DMX-600 C14H19NO.HCl). Field strength: 600 MHz Solvent: D2O (4.79 ppm) Internal standard: Maleic acid (98.7% m/m) Initial analysis: Mean (1.6 ppm) = 99.7%, s = 0.1% (5 sub samples, March 2011) Initial analysis: Mean (5.2 ppm) = 100.0%, s = 0.2% (5 sub samples, March 2011)

1 Suakin Street Pymble, NSW 2073 PO Box 385 Pymble NSW 2073 Tel: +61 2 9449 0111 Fax: +61 2 9449 1653 www.measurement.gov.au ABN: 74 599 608 295 1 Suakin Street Pymble, NSW 2073 PO Box 385 Pymble NSW 2073 Tel: +61 2 9449 0111 Fax: +61 2 9449 1653 www.measurement.gov.au ABN: 74 599 608 295 ______National Measurement Institute National Measurement Institute Page 1 of 3 Page 2 of 3

Expiration of certification The property values are valid till 24th March 2014, i.e. three years from the date of certification provided the unopened material is handled and stored in accordance with the recommendations below. The material as issued in the unopened container and stored as recommended below should be suitable for use beyond this date, subject to confirmation of batch stability from the issuing body. The expiry date/shelf life does not apply to sample bottles that have been opened. In such cases, it is recommended that the end-user conduct their own in-house stability trials. The long-term stability of the compound in solution has not been examined. This material has been given a shelf life of three years from the date of certification. The material will be re- tested on an annual basis to ensure that the property values are still valid. In the event a product fails the stability trial, notification will be sent to all impacted customers. In the absence of stability data the measurement uncertainty at the 95% coverage interval has been expanded to accommodate any potential change in the property value. The stability component has been estimated from stability trials conducted on similar materials by NMI Australia over the last 10 years. Homogeneity assessment The homogeneity of the material was assessed using purity assay by HPLC with UV detection on ten randomly selected 1-2 mg sub samples of the material. The material was judged to be homogeneous at this level of sampling as the variation in analysis results between samples was not significantly different at a 95% confidence level from that observed on repeat analysis of the same sample. Recommended storage When not in use, this material should be stored at or below 20 ºC in a closed container in a dry, dark area. Intended Use For in vitro laboratory analysis only. Caution Treat as hazardous substance. Use appropriate work practices when handling to avoid skin or eye contact, ingestion or inhalation of dust. Legal notice Neither NMI nor any person acting on NMI’s behalf assumes any liability with respect to the use of, or for damages resulting from the use of, this reference material or the information contained in this certificate.

Authorised by:

Dr Stephen R. Davies, Team Leader, Chemical Reference Materials, NMI. Dated: 1 July, 2011.

Characterisation data and property values specified in this report were first issued on 1st July 2011.

1 Suakin Street Pymble, NSW 2073 PO Box 385 Pymble NSW 2073 Tel: +61 2 9449 0111 Fax: +61 2 9449 1653 www.measurement.gov.au ABN: 74 599 608 295 ______National Measurement Institute Page 3 of 3 Drugs and metabolites of forensic and clinical interest Drugs and metabolites of forensic and clinical interest Drugs of abuse and metabolites

Code Product Unit LGCFOR1275.71 AB-001 (Adamantyl(1-pentylindol-3-yl)methanone) 10 mg O

TRC-A105000 Abacavir sulfate 5 mg CERA-064 Acetaminophen (1.0 mg/ml) (Paracetamol) H 1 mL N CH in Methanol 3

O HO

CERP-909 Acetaminophen-D4 (0.1 mg/ml) (Paracetamol) D 1 mL

in Methanol D NH CCH3 O HO D D

CERP-917 Acetaminophen-D4 (1.0 mg/ml) (Paracetamol) D H 1 mL in Methanol D N CH3

O HO D D

NMIAD445 N-Acetylamphetamine CH3 50 mg N H O

NMIAD821 Acetylcodeine base OH3C 50 mg

O H CH N 3

OOCH3C

CERA-053 6-Acetylcodeine (1.0 mg/ml) CH3O 1 mL in Acetonitrile

N CH3 O

CH3 C O

LGCFOR1275.28 4-Acetoxy-N,N-diisopropyltryptamine Hydrochloride (4-AcO-DIPT 10 mg O HCl, 4-Acetoxy-DIPT HCl, Ipracetin HCl) N O x HCl

N H O OH LGCFOR1275.29 4-Acetoxy-N-methyl-N-ethyltryptamine Fumarate (4-AcO-MET N 10 mg O Fumarate, 4-Acetoxy-MET Fumarate) O x

O N HO H NMIAD738 (±)-N-Acetyl-3,4-methylenedioxyamphetamine O 50 mg HN O O CERA-003 6-Acetylmorphine (0.1 mg/ml) HO 1 mL in Acetonitrile

N CH3 O

CH3 C O

82 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERA-009 6-Acetylmorphine (1.0 mg/ml) HO 1 mL in Acetonitrile

N CH 3 O

CH3 C O

CERA-006 6-Acetylmorphine-D3 (0.1 mg/ml) HO 1 mL in Acetonitrile

N CD 3 O

CH 3 C O

CERA-010 6-Acetylmorphine-D3 (1.0 mg/ml) HO 1 mL in Acetonitrile

N CD3 O

CH3 C O

CERA-026 6-Acetylmorphine-D6 (0.1 mg/ml) HO 1 mL in Acetonitrile

N CD 3 O

CD3 C O

CERA-027 6-Acetylmorphine-D6 (1.0 mg/ml) HO 1 mL in Acetonitrile

N CD 3 O

CD3 C O

NMIAD697 N-Acetylnorlaudanosine OMe 10 mg

OMe MeO Ac N

MeO LGCFOR0133.00 Acetylsalicylic Acid O 10 mg OH

O NMIAD704 Acetylthebaol MeO 5 mg

AcO

MeO LGCFOR0061.00 Aciclovir O 10 mg N HN OH N H2N N O CERA-066 Acyclovir O 100 mg N HN OH N H2N N O OH LGCFOR0614.02 L-Adrenaline H 10 mg HO N

CH3 CERA-067 Albuterol (1.0 mg/ml) H3C 1 mL in Methanol HO CH3 NH

OH CERA-071 Alfentanyl HCl (1.0 mg/ml ) (as free base) 1 mL in Methanol HCl

N N N H3C N O N N O CH 3 H3C O

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 83

Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERM-107 Alphamethadol HCl (1.0 mg/ml) OH CH3 1 mL HCl in Methanol H3CN CH3 CH3

CERA-903 Alprazolam (1.0 mg/ml) Cl 1 mL in Methanol

CH 3 N N N N

CERA-902 Alprazolam-D5 (0.1 mg/ml) Cl 1 mL in Methanol D D

CH 3 D N N N D D N

CERA-910 Alprazolam-D5 (1.0 mg/ml) Cl 1 mL in Methanol D D

CH 3 D N N N D D N LGCFOR1275.17 AM-694 (1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole) O I 10 mg

F THC-1359-M AM-1220 (1 mg/ml) in Methanol 1 mL THC-1372M AM-2201 (1-(5-fluoropentyl)-3-(naphthalen-1-oyl)indole) ( 1 mg/mL) 1 mL in Methanol

LGCFOR0028.03 2-Amino-5-chlorobenzophenone NH2 10 mg

O Cl

CERA-915 7-Aminoclonazepam (0.1 mg/ml) H 2 N 1 mL in Acetonitrile

N Cl O

CERA-916 7-Aminoclonazepam (1.0 mg/ml) H 2 N 1 mL in Acetonitrile

N Cl O

CERA-917 7-Aminoclonazepam-D4 (0.1 mg/ml) H 2 N 1 mL in Acetonitrile D D

D NH N O D Cl LGCFOR0171.01 N-(2-Aminoethyl)-2-(benzylphenylamino)acetamide 10 mg Dihydrochloride O x 2 HCl N NH2 N H

CERA-912 7-Aminoflunitrazepam (0.1 mg/ml) H 2 N 1 mL in Acetonitril

N CH3 N F O

84 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERA-911 7-Aminoflunitrazepam (1.0 mg/ml) H2N 1 mL in Acetonitril

N CH3 N F O CERA-925 7-Aminoflunitrazepam-D7 (1.0 mg/ml) 1 mL in Acetonitrile

CERA-921 7-Aminoflunitrazepam-D7 (0.1 mg/ml) H2N 1 mL in Acetonitrile D D

D N CD3 N O D F LGCFOR1275.50 2-Aminoindane Hydrochloride (2-AI HCl) 10 mg NH2 x HCl

H O LGCFOR0078.07 7-Aminonitrazepam N 10 mg

H2N N

CERA-914 7-Aminonitrazepam (0.1 mg/ml) H 2 N 1 mL in Acetonitrile

NH N O

CERA-913 7-Aminonitrazepam (1.0 mg/ml) H2N 1 mL in Methanol

NH N O

LGCFOR0078.01 2-Amino-5-nitrobenzophenone NH2 10 mg O O2N

CERA-040 Aminorex (1.0 mg/ml) HH 1 mL in Acetonitrile H NO

NH2 TRC-A632950 Amiodarone HCl 5 g CERA-060 Amiodarone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

TRC-A632952 Amiodarone HCl-D4 2.5 mg CERA-083 Amiodarone-D4 HCl (0.1 mg/ml) 1 mL in Methanol

TRC-A633250 Amisulpride 10 mg TRC-A633252 Amisulpride-D5 1 mg LGCFOR0062.00 Amitriptyline HCl 10 mg

N x HCl

CERA-923 Amitriptyline (1.0 mg/ml) (as free base) 1 mL in Methanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERA-085 Amitriptyline-D3 HCl (0.1mg/ml) (as free base) 1 mL

CERA-020 Amobarbital (1.0 mg/ml) H 1 mL in Methanol O N O

CH3 CH2 CH3 N H CH CH2 CH2 O CH3

CERA-011 (±)-Amphetamine (0.1 mg/ml) H CH 3 1 mL C C in Methanol NH2 H H

CERA-007 (±)-Amphetamine (1.0 mg/ml) H CH 3 1 mL C C in Methanol NH2 H H CERA-049 R(-)-Amphetamine (1.0 mg/ml) (Levamfetamin) H 1 mL in Methanol NH 2 CH3

H CERA-008 S(+)-Amphetamine (dextro-Amphetamine) (1.0 mg/ml) NH 1 mL CH2 2 in Methanol C

CH3

NMIAD420 (±)-Amphetamine Sulfate 50 mg CH3 2- SO4 NH3 2

CERA-005 (±)-Amphetamine-D5 (0.1 mg/ml) D CD3 1 mL

(deuterium label on side chain) C C NH2 in Methanol H D

CERA-013 (±)-Amphetamine-D5 (1.0 mg/ml) D CD3 1 mL

in Methanol C C NH2 D D

CERA-002 (±)-Amphetamine-D5 (0.1 mg/ml) D D 1 mL (deuterium label on ring) H CH3 C in Methanol D C NH2 H H D D

CERA-044 Amphetamine-D6 (0.1 mg/ml) D CD3 1 mL

in Methanol C C NH2 D D

CERA-045 Amphetamine-D6 (1.0 mg/ml) D CD3 1 mL

in Methanol C C NH2 D D

CERA-017 (±)-Amphetamine-D8 (0.1 mg/ml) DD 1 mL in Methanol H CD 3 C C D NH2 H H D D

CERA-018 (±)-Amphetamine-D8 (1.0 mg/ml) DD 1 mL in Methanol H CD 3 C C D NH2 H H D D

CERA-038 (±)-Amphetamine-D10 (0.1 mg/ml) D D 1 mL in Methanol H CD 3 C D C NH 2 D D D D

CERA-016 (±)-Amphetamine-D11 (0.1 mg/ml) DD 1 mL in Methanol D CD3 C D C NH2 D D D D

86 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERA-019 (±)-Amphetamine-D11 (1.0 mg/ml) DD 1 mL in Methanol D CD3 C D C NH2 D D D D TRC-A634400 Amprenavir 5 mg TRC-A634402 Amprenavir-D4 1 mg CERA-097 (+)-Anabasine HCl (1.0 mg/mL) (as free base) 1 mL in Methanol

LGCFOR0565.00 Androstanolone (5alpha-Dihydrotestosterone, Stanolone) OH 10 mg

O H LGCFOR0323.01 Androstenedione O 10 mg

O CERA-084 Androstene-3,17-dione-2,3,4-13C3 (0.1 mg/ml) 1 mL in Acetonitrile

CERA-036 Anhydroecgonine HCl (1.0 mg/ml) CH 3 1 mL in Methanol N COOH HCl

NMIAD847 Anhydroecgonine methyl ester CH3 N COOCH3

CERA-034 Anhydroecgonine methyl ester (1.0 mg/ml) CH 3 1 mL N in Acetonitrile COOCH 3

LGCFOR0007.04 2-Anhydrotramadol Hydrochloride (2-(3-Methoxyphenyl)-N,N-dimethyl- O 10 mg 2-cyclohexene-1-methanamine Hydrochloride) x HCl N

LGCFOR1275.25 6-APDB (1-(2,3-Dihydro-1-benzofuran-6-yl)propan-2-amine, O NH2 10 mg 6-(2-Aminopropyl)-2,3-dihydrobenzofuran, 4-Desoxy-MDA)

LGCFOR0562.00 Apomorphine HCl OH 10 mg HO x HCl x 1/2 H2O N H

LGCFOR0467.00 Aprindine Hydrochloride N 10 mg

N x HCl

CERA-080 Aripiprazole (1.0 mg/mL ) 1 mL in Acetonitrile

CERA-081 Aripiprazole-D8 (0.1 mg/ml) 1 mL in Acetonitrile

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERA-094 Ascomycin (1.0 mg/mL) 1 mL in Acetonitrile

TRC-A790051 Atazanavir 5 mg TRC-A790052 Atazanavir-D5 1 mg OH LGCFOR0013.00 Atenolol H 10 mg O N O

H2N CERA-072 Atenolol (1.0 mg/ml) 1 mL in Acetonitrile

CERA-095 Atomoxetine HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERA-093 Atomoxetine-D7 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

CERA-078 Atorvastatin calcium salt (1.0 mg/ml) (as free carboxylate) 1 mL in Methanol

CERA-046 Atropine (1.0 mg/ml) CH 3 1 mL N in Acetonitrile

O CCH

CH 2OH CERA-077 Atropine-D3 (0.1 mg/ml) 1 mL in Acetonitrile

H LGCFOR0289.00 Atropine sulphate O 10 mg H x H2SO4 N O x H2O and enantiomer OH H 2

H LGCFOR0265.03 Barbituric Acid O N O 10 mg

CERB-016 (±)-BDB HCl (1.0 mg/ml) H CH2 CH3 1 mL O in Methanol CCNH2 H H O HCl LGCFOR0456.00 Benzbromarone O 10 mg Br O OH Br

LGCFOR1275.36 Benzedrone Hydrochloride (4-Methyl-N-benzylcathinone O 10 mg H Hydrochloride) N x HCl

LGCFOR0490.02 Benzhydrol (Diphenylmethanol) 10 mg

LGCFOR0094.00 Benzocaine O 10 mg O

H2N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERB-007 Benzoylecgonine (0.1 mg/ml) CH3 1 mL in Methanol N COOH H O

O C

CERB-004 Benzoylecgonine (1.0 mg/ml) CH3 1 mL in Methanol N COOH H O

O C

CERB-001 Benzoylecgonine-D3 (0.1 mg/ml) CD 3 1 mL in Methanol N COOH H O OC

CERB-008 Benzoylecgonine-D3 (1.0 mg/ml) CD3 1 mL in Methanol N COOH H O

O C H

CERB-013 Benzoylecgonin-D8 (0.1 mg/ml) CD3 1 mL in Methanol N COOH H D D O

OC D H D D

CERB-014 Benzoylecgonine-D8 (1.0 mg/ml) CD3 1 mL in Methanol N COOH H DD O

O C D H DD

CERB-010 Benzoylecgonine isopropyl ester (1.0 mg/ml) CH3 1 mL N COOCH(CH3)2 in Acetonitrile H O

H C NMIAD745 Benzoylecgonine tetrahydrate 3 N COOH 50 mg H

O .4H2O H O TRC-B276580 Benzyl fentanyl 1 mg TRC-B276582 Benzyl fentanyl-D3 1 mg NMIAD868 Benzyl methyl ketone (P2P) - DRUG PRECURSOR 10 mg O

NMIAD456 1-Benzyl-3-methylnaphthalene 50 mg

CH3 NMIAD905 BZP (Benzyl piperazine dihydrochloride) HCl 50 mg N NH HCl NMIAD905 BZP (Benzyl piperazine dihydrochloride) HCl 50 mg N NH HCl CERB-906 Benzylpiperazine diHCI (1.0 mg/ml) HCl 1 mL in Methanol N NH HCl CERB-907 Benzylpiperazine-D7 diHCl (0.1 mg/ml) 1 mL in Methanol TRC-B288612 N-Benzylpiperazine-D8 diHCl 1 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

OH OH LGCFOR0460.08 Bisoprolol Fumarate H 10 mg O N O x

O O O 2 HO LGCFOR0864.00 Boldenone OH 10 mg

O CERB-042 Boldenone (1.0 mg/ml) 1 mL in Acetonitrile

H O LGCFOR0064.00 Bromazepam N 10 mg

Br N

CERB-903 Bromazepam (1.0 mg/ml) Br 1 mL in Methanol

NH N N O NMIAD396 DOB ((±)-4-Bromo-2,5-dimethoxyamphetamine HCl OMe 20 mg CH3 (Brolamfetamin) NH2 .HCl Br OMe NMIAD758 (±)-4-Bromo-2,5-dimethoxyphenethylamine HCl (Nexus) OMe 20 mg .HCl NH2

Br OMe

CERB-026 4-Bromo-2,5-dimethoxyphenethylamine HCl (1.0 mg/ml) CH3O NH2 1 mL in Methanol HCl

Br OCH3 TRC-B684210 (R)-(-)-Bromodragonfly HCl 10 mg

NMIAD455 Bromosaffrole CH3O NH2 50 mg

Br OCH3

LGCFOR0060.00 Brompheniramine maleate O 100 mg N OH x OH N O Br

CERB-023 BSTFA with 1% TMCS CH3 CF3 CH3 10 x 1 mL

CH3 Si OCN SiCH3

CH3 CH3 CH3

+ H3C Si Cl

CH3

TRC-B689450 Buclizine dihydrochloride 50 mg

CERB-022 Bufotenine (1.0 mg/ml) H 1 mL N in Acetonitrile

HO CH2CH2N(CH3)2

O H LGCFOR1275.19 Buphedrone N 10 mg

NMIAD932 Buprenorphine, free base HO 10 mg

O N

CH3O H

HO CH3 C(CH3)3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERB-044 Buprenorphine (1.0 mg/ml) HO 1 mL in Methanol O

N CH 2

CH 3 O

HO C CH 3

C(CH 3 ) 3

CERB-902 Buprenorphine (0.1 mg/ml) HO 1 mL in Methanol

N CH 2

CH 3 O

HO C CH 3

C(CH 3 ) 3

CERB-901 Buprenorphine-D4 (0.1 mg/ml) HO 1 mL in Methanol

D O DD D NC

CH 3 O

HO C CH 3

C(CH 3 ) 3 CERB-908 Buprenorphine-D4 (1.0 mg/ml) 1 mL in Methanol

CERB-035 Buprenorphine-3beta-D-glucuronide (0.1 mg/mL) HOOC O O 1 mL in Methanol HO OH O OH N

H3C O

HO CH3 C(CH3)3 O LGCFOR0745.00 Bupropion HCl H 10 mg Cl N x HCl

HCl CERB-034 Bupropion HCl (1.0 mg/ml) (as free base) O 1 mL in Methanol Cl NH CH3

CH3 CH CH3 3

CERB-024 Butabarbital (1.0 mg/ml) (Secbutabarbital) H 1 mL in Methanol O NO

CH3 CH2 N H CH3 CH2 CH O CH3

CERB-005 Butalbital-D5 (0.1 mg/ml) H 1 mL in Methanol O N O

CD2 CD CD2 N H3C H CH CH2 H3C O

CERB-030 Butalbital-D5 (1.0 mg/ml) H 1 mL in Methanol O N O

CD2 CD CD2 N H3C H CH CH2 H3C O

CERB-006 Butalbital (1.0 mg/ml) H 1 mL in Methanol O N O

CH2 CH CH2 N H3C H CH CH2 H3C O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERB-020 1,4-Butanediol (1.0 mg/ml) OH 1 mL in Methanol HO CERB-037 Butorphanol tartrate (1.0 mg/ml) (as free base) HO 1 mL in Methanol HO COOH

N OH HOOC OH

O NMIAD948 Butylone HCl ° H 20 mg (1-(3,4-Methylenedioxyphenyl)-2-(methylamino)butan-1-one) O N HCl O CERB-046 Butylone-D3 HCl (bk-MBDB, B1) (0.1 mg/ml) (as free base) 1 mL in Methanol

O H LGCFOR1275.03 Butylone Hydrochloride N 10 mg O x HCl

O H N CERB-045 Butylone HCl (1.0 mg/ml) (as free base) O x HCl 1 mL

in Methanol O

CERB-018 gamma-Butyrolactone (1.0 mg/ml) O O 1 mL in Acetonitrile

CERB-032 gamma-Butyrolactone-D6 (1.0 mg/ml) D 1 mL O O in Acetonitrile D D D D D

O LGCFOR1275.32 Buphedrone Hydrochloride H 10 mg N x HCl

LGCFOR0494.00 Caffeine O 10 mg N N

O N N

NMIAM724 Caffeine O 50 mg N N N O N

O CERC-051 Caffeine (1.0 mg/ml) CH3 1 mL in Methanol H3C N N

O N N

CH3

NMIAD512 Cannabidiol CH3 50 mg OH

HO C5H11 CERC-045 Cannabidiol (1.0 mg/ml) CH3 1 mL in Methanol OH

H2C O CH3 H3C H THC-1073M Cannabidiol (1 mg / mL) 1 mL in Methanol THC-1284M Cannabidiol-D3 (0.1 mg / mL) 1 mL in Methanol

CERC-046 Cannabinol (1.0 mg/ml) CH3 1 mL

in Methanol OH

H3C O CH3 H3C

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR0076.00 Carbamazepine O 10 mg

N NH2

CERC-053 Carbamazepine (1.0 mg/ml) 1 mL in Methanol N

O NH2

CH3 CERC-042 Carisoprodol CH3 O 500 mg

H3C N O O O H H3C NH2 CERC-077 Carisoprodol (1.0 mg/ml) 1 mL in Methanol

NMIAM297 (+)-Norpseudoephedrine HCl (Cathine) OH 50 mg NH2 HCl CERN-046 Norpseudoephedrine HCl (0.1 mg/ml) as free base 1 mL in Methanol

CERC-094 Carbamazepine-D10 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0076.01 Carbamazepine 10,11-Epoxide O 10 mg

N NH2

CERC-111 Catecholamine Metabolites Mix(1.0 mg/ml) of each component 1 mL in Methanol TRC-C225702 Cathinone-D3 HCl 1 mg NMIAD929 (±)-Cathinone HCl O 20 mg NH2 .HCl

CH3

O CERC-028 R(+)-Cathinone HCl (1.0 mg/ml) H 1 mL in Methanol C C CH 3

NH 2 HCl

CERC-019 S(-)-Cathinone HCl (1.0 mg/ml) (as free base) O 1 mL H in Methanol C CNH2

CH 3 HCl

O OH LGCFOR0128.00 Celiprolol Hydrochloride H 10 mg O N O x HCl N N H

O LGCFOR0380.13 Cetirizine N-Oxide O 10 mg Cl O N OH N

CERC-022 Chlordiazepoxide (1.0 mg/ml) Cl 1 mL in Methanol

NHCH3 O CERC-912 Chlordiazepoxide-D5 (0.1 mg/mL) 1 mL in Methanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0017.00 Chlormezanone Cl 10 mg OO S

O LGCFOR0071.04 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid O 10 mg N OH N Cl Cl

H LGCFOR0071.09 6-Chloro-4-(2-chlorophenyl)-2(1H)-quinazolinone N O 10 mg

N Cl Cl

LGCFOR0015.01 (2-Chlorophenyl)diphenylmethanol 10 mg

Cl HO

Cl OH LGCFOR0380.01 1-[(4-Chlorophenyl)phenylmethyl]piperazine N 10 mg N

x 2 HCl

Cl OH LGCFOR0380.11 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol N 10 mg Dihydrochloride N x 2 HCl

NMIAD907 m-Chlorophenylpiperazine HCl (mCPP) Cl 50 mg

N NH

HCl CERC-089 1-(3-Chlorophenyl)piperazine (mCPP) HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

LGCFOR1275.16 ortho-Chlorophenylpiperazine Hydrochloride (oCPP HCl) NH 10 mg N x HCl

Cl TRC-C379965 Chloroquine diphosphate salt 100 mg LGCFOR0090.00 Chlorphenamine Maleate Cl 10 mg O

OH x N OH N O

CERC-036 Chlorpheniramine maleate (1.0 mg/ml) CH 3 1 mL in Methanol Cl CH CH 2 CH 2 N CH 3 N HOOC COOH CC H H LGCFOR0420.00 Chlorpromazine Hydrochloride 10 mg N N x HCl S

Cl CERC-904 Chlorpromazine HCl (1.0 mg/ml) S 1 mL in Methanol N Cl CH 3 CH 2 CH 2 CH 2 N CH 3

CERC-902 Chlorpromazine-D3 (0.1 mg/ml) S 1 mL in Methanol N Cl CD 3 CH 2 CH 2 CH 2 N CH 3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0420.01 Chlorpromazine Sulphoxide 10 mg

N N S O

Cl CERC-074 Chlorzoxazone (0.1 mg/ml) H 1 mL Cl N in Acetonitrile O O H H CERC-055 Cimetidine N N 250 mg N S CH3 N N CH H 3 N

NMIAD468 trans-Cinnamoylcocaine H3C 20 mg N COOMe H

O H O LGCFOR0242.00 Citalopram HBr F 10 mg

x HBr

N O

H3C N CERC-057 Citalopram HBr (0.1 mg/ml) (as free base) CH3 1 mL HBr

in Methanol F

N CERC-095 Citalopram HBr (1.0 mg/mL) (as free base) 1 mL in Methanol

CERC-090 Citalopram-D6 HBr (0.1 mg/ml) (as free base) 1 mL in Methanol CERC-909 Clobazam (1.0 mg/ml) Cl 1 mL in Methanol

NCHN 3

oo NMIAD692 Clobenzorex HCl 20 mg NH . HCl Cl LGCFOR0038.00 Clobutinol Hydrochloride 10 mg N x HCl OH Cl LGCFOR0545.00 Clomipramine HCl Cl 10 mg

N N x HCl

CERC-903 Clomipramine (1.0 mg/ml) 1 mL in Methanol

Cl N CH3 CH2 CH2 CH2 N CH3

CERC-901 Clomipramine-D3 (0.1 mg/ml) 1 mL in Methanol Cl N CD3

CH 2 CH 2 CH 2 N

CH 3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERC-907 Clonazepam (1.0 mg/ml) O2N 1 mL in Methanol

N Cl O

CERC-905 Clonazepam-D4 (0.1 mg/ml) O2N 1 mL in Methanol DD

D NH N D Cl O CERC-906 Clonazepam-D4 (1.0 mg/ml) 1 mL in Methanol

Cl LGCFOR0983.00 Clonidine Hydrochloride HN 10 mg x HCl N N H Cl

Cl CERC-033 Clonidine (1.0 mg/ml) H 1 mL in Methanol N N N H Cl CERC-092 Clopidogrel carboxylic acid HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

LGCFOR0480.00 Clozapine Cl N 10 mg N N

TRC-C587502 Clozapine-d8 1 mg

CERC-059 Clozapine (1.0 mg/ml) CH3 1 mL in Methanol N N N Cl

N H CERC-091 Clozapine-D4 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0682.00 Cloxacillin Sodium Monohydrate Cl O 10 mg ONa O N N H x H2O O N S H O

CERC-010 Cocaethylene (1.0 mg/ml) CH 3 1 mL (Benzoylethylecgonin) N COOCH 2 CH 3 in Acetonitrile H O

O C

CERC-009 Cocaethylene-D3 (0.1 mg/ml) C D 3 1 mL C OO C H C H in Acetonitrile N 2 3 H O

O C

CERC-024 Cocaethylene-D8 (0.1 mg/ml) CD 3 1 mL in Acetonitrile N COOCD 2 CD 3 H O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit NMIAD826 Cocaine base Me O 50 mg N OMe H O Ph

H O

NMIAD747 Cocaine HCl H3C 20 mg N COOCH3 H O OC H

CERC-008 Cocaine (1.0 mg/ml) CH 3 1 mL in Acetonitrile N COOCH 3 H O

CERC-004 Cocaine-D3 (0.1 mg/ml) CD 3 1 mL in Acetonitrile N COOCH 3 H O

CERC-014 Cocaine-D3 (1.0 mg/ml) CD3 1 mL in Acetonitrile N COOCH3 H O O C H

NMIAD671 Codeine base CD3 50 mg N COOCH3 H O O C H

NMIAD673 Codeine base-D3 MeO 1 mg

O H CD N 3

CERC-015 Codeine (0.1 mg/ml) CH3O 1 mL in Methanol

O N CH3

CERC-006 Codeine (1.0 mg/ml) CH 3 O 1 mL in Methanol

N CH 3

CERC-005 Codeine-D3 (0.1 mg/ml) CH 3 O 1 mL in Methanol

N CD 3

CERC-039 Codeine-D3 (0.1 mg/ml) CH3O 5 mL in Methanol

O N CD3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERC-007 Codeine-D3 (1.0 mg/ml) CH3O 1 mL in Methanol

O N CD3

CERC-040 Codeine-D6 (0.1 mg/ml) CD3O 1 mL in Methanol

N CD 3

CERC-041 Codeine-D6 (1.0 mg/ml) CD3O 1 mL in Methanol

O N CD3

NMIAD694 Codeine glucuronide * OH3C 0.1 mg

O N CH HOOC 3 HO O HO O HO

NMIAD695 Codeine glucuronide-D3* OH3C 0.1 mg

O N CD HOOC 3 HO O HO O HO CERC-087 Codeine-6-beta-D-glucuronide (0.1 mg/ml) 1 mL in Water/Methanol (80:20)

LGCFOR0442.00 Codeine phosphate hemihydrate N 10 mg

x H3PO4 x 1/2 H2O

O O OH LGCFOR1083.00 Colchicine O 10 mg NH O O O O O LGCFOR0214.00 Cortisone O 10 mg OH O OH

O LGCFOR0517.03 Cotinine 10 mg N N O

CERC-016 (-)-Cotinine (1.0 mg/ml) H 1 mL

in Methanol N O

CH 3 N

CERC-017 (±)-Cotinine-D3 (0.1 mg/ml) 1 mL

in Methanol N O

CD N 3 CERC-035 (±) Cotinine-D3 (1.0 mg/ml) 1 mL

in Methanol N O

CD3 N

CERC-073 Coumarin (1.0 mg/ml) OO 1 mL in Acetonitrile

98 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit THC-1240 CP 47,497 5 mg (2-((1R,3S/1S,3R)-3-hydroxycyclohexyl)-5-(2-methyloctan-2-yl)phenol) THC-1187 CP47,497 (2-((1R,3S/1S,3R)-3-hydroxycyclohexyl)-5-(2-methyloctan-2-yl)phenol) CAY-16851 (+/-) CP47,497 5 mg (5-(1,1-Dimethylheptyl)-2-((1R,3S)-3-hydroxycyclohexyl)-phenol) THC-1186 CP47,497 1 mL (5-(1,1-Dimethylheptyl)-2-((1R,3S)-3-hydroxycyclohexyl)-phenol) (1.0 mg / ml) in Methanol CAY-13218 (-) CP47,497 5 mg (5-(1,1-Dimethylheptyl)-2-((1R,3S)-3-hydroxycyclohexyl)-phenol) CAY-13219 (+) CP47,497 5 mg (5-(1,1-Dimethylheptyl)-2-((1R,3S)-3-hydroxycyclohexyl)-phenol) CAY-90084 (-)-CP 55,940 5 mg (5-(1,1-dimethylheptyl)-2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-phenol) TRC-C781502 Creatinine-D3 2.5 mg CERC-060 Cyclobenzaprine HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERC-114 Cyclobenzaprine-D3 HCl 0.1 mg/ml) (as free base) 1 mL in Methanol

CERC-104 Cyclosporin A (0.1 mg/ml) 1 mL in Acetonitrile

CERC-093 Cyclosporin A (1.0 mg/mL) 1 mL in Acetonitrile

CERC-108 Cyclosporin D (1.0 mg/mL) 1 mL in Acetonitrile

TRC-D193500 Darunavir 5 mg TRC-D193502 Darunavir-D9 1 mg CERD-066 Dehydroepiandrosterone-D5-3-sulfate sodium salt (DHEAS-D5) (2,2,3,4,4-D5) (O.1 mg/ml) 1 mL in Methanol CERD-046 Dehydronorketamine HCl (0.1 mg/ml) (as free base) 1 mL in Acetonitrile

TRC-D230625 Delavirdine 10 mg TRC-D230630 Delavirdine mesylate 10 mg H O LGCFOR0028.02 Demoxepam N 10 mg

Cl N O

CERD-079 Demoxepam (1.0 mg/mL) in Acetonitrile 1 mL

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERD-080 Demoxepam-D5 (0.1 mg/ml)

LGCFOR0185.08 11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) O 10 mg OH OH

O CERD-076 21-Deoxycortisol-D8 (2,2,4,6,6,21,21,21-D8) (0.1 mg/ml) 1 mL in Methanol

LGCFOR0068.05 Desacetyldiltiazem O 10 mg

S OH N O

LGCFOR0070.02 Desalkylflurazepam (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H- H O 10 mg N 1,4-benzodiazepin-2-one)

Cl N

CERD-915 Desalkylflurazepam (1.0 mg/ml) Cl 1 mL in Methanol

NH N O F

CERD-924 Desalkylflurazepam-D4 (0.1 mg/ml) Cl 1 mL in Methanol D D

D NH N O D F CERD-055 N-Desethylamiodarone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERD-056 N-Desethylamiodarone-D4 HCl (0.1 mg/ml) (as free base) i 1 mL n Methanol

CERD-040 N-Desethylamodiaquine-D5 diHCl (0.1 mg/ml) 1 mL in Methanol

TRC-D288735 Desethylchloroquine 2.5 mg LGCFOR0764.02 Desethylhydroxychloroquine Dihydrochloride Cl N 10 mg x 2 HCl

HN OH N H LGCFOR0422.01 Deshydroxyethylopipramol Dihydrochloride (5-(3-Piperazin-1-yl- 10 mg

propyl)-5H-dibenzo[b,f]azepine Dihydrochloride) N x 2 HCl

N NH LGCFOR0589.00 Desipramine Hydrochloride 10 mg

N N x HCl H

100 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERD-906 Desipramine (1.0 mg/ml) 1 mL in Methanol N

CH2 CH2 CH2 NH CH3 HCl CERD-903 Desipramine-D3 HCl (0.1 mg/ml) 1 mL in Methanol N

CH2 CH2 CH2 NH CD3 HCl

LGCFOR0060.16 Desmethylbrompheniramine Maleate O 10 mg N OH x OH N H O Br LGCFOR0090.13 Desmethylchlorphenamine Maleate Cl 10 mg O

OH x OH N NH O

LGCFOR0242.09 Desmethylcitalopram Hydrochloride F 10 mg

x HCl

N O H

N CERD-047 N-Desmethylcitalopram HCl (1.0 mg/mL) (as free base) 1 mL in Methanol

CERD-049 N-Desmethylclobazam (0.1 mg/ml) 1 mL in Acetonitrile

LGCFOR0545.08 Desmethylclomipramine HCl Cl 10 mg

N N x HCl H

CERD-916 N-Desmethylclomipramine (1.0 mg/ml) (as free base) 1 mL in Methanol Cl N H

CH2 CH2 CH2 N CH3

LGCFOR0480.03 Desmethylclozapine (Norclozapine) Cl NH 10 mg N N

CERD-048 N-Desmethylclozapine (1.0 mg/mL) 1 mL in Methanol

H LGCFOR0033.10 N-Desmethyldextromethorphan Hydrochloride (ent- N 10 mg 3-Methoxymorphinan Hydrochloride) x HCl

LGCFOR0033.09 O-Desmethyldextromethorphan Hydrochloride N 10 mg (ent-17-Methylmorphinan-3-ol (L)-Tartrate) OH O HO x OH O OH

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0068.03 N-Desmethyldiltiazem HCl O 10 mg

S O x HCl N O O

CERD-007 Desmethyldoxepin (cis/trans) (1.0 mg/ml) O 1 mL in Methanol

CH CH 2 CH 2 NH CH 3

H O LGCFOR0069.02 Desmethylflunitrazepam N 10 mg

O2N N

O N CERD-919 Desmethylflunitrazepam(0.1 mg/ml) 2 1 mL in Methanol

N H N F O

CERD-918 Desmethylflunitrazepam (1.0 mg/ml) O2N 1 mL in Methanol

N H N F O

CERD-925 N-Desmethylflunitrazepam-D4 (0.1 mg/ml) O2N 1 mL in Methanol D D

D NH N D F O LGCFOR0019.07 N-Desmethyllevomepromazine Hydrochloride 10 mg

N N H x HCl S

O CERD-069 Desmethylolanzapine diHCl (1.0 mg/ml) 1 mL in Acetonitrile : Water (1:1)

CERD-070 N-Desmethylolanzapine-D8 dihydrochloride (0.1 mg/ml) (as free base) 1 mL in 1:1 Acetonitrile:Water

TRC-D292145 O-Desmethylquinine 5 mg

CERD-012 (±)-N-Desmethylselegiline (1.0 mg/ml) H CH3 1 mL

in Methanol CCNH CH2 CCH H H

CERD-016 N-Desmethylselegiline-D11 (0.1 mg/ml) D D 1 mL D CD in Methanol 3

D CCNH CH2CCH D D D D LGCFOR0991.02 Desmethylsibutramine Hydrochloride 10 mg x HCl

HN Cl LGCFOR0254.08 Desmethylsildenafil (1-[[3-(4,7-Dihydro-1-methyl-7-oxo- O 10 mg 3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)- HN N O O N 4-ethoxyphenyl]sulfonyl]piperazine) S N N HN O

102 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR0051.07 O-Desmethylsulpiride O O 10 mg O S N N H2N H OH CERD-052 N-Desmethyltapentadol (1.0 mg/ml) 1 mL in Methanol

LGCFOR0007.06 O-Desmethyltramadol HCl HO 10 mg OH x HCl N

and enantiomer CERD-058 O-Desmethyl-cis-tramadol-D6 HCl (0.1 mg/ml) (as free base) 1 mL

CERT-035 O-Desmethyl-cis-tramadol HCl (1 mg/ml) (as free base) H3C 1 mL in Methanol N CH3

HCl HO HO

CERD-023 N-Desmethyl-cis-tramadol HCl (1.0 mg/ml) H 1 mL CH NCH in Methanol H 2 3 HCl

CH3O

LGCFOR0240.02 Desmethyltrimipramine HCl 10 mg

N N H x HCl

CERD-920 N-Desmethyltrimipramine maleate (1.0 mg/ml) 1 mL in Methanol

CH 2 CH CH 2 NH CH 3

CH 3 H H CC HOOC COOH LGCFOR0393.04 N-Desmethylvenlafaxine Hydrochloride 10 mg OH

H x HCl N

O LGCFOR0393.01 O-Desmethylvenlafaxine 10 mg OH

HO LGCFOR1275.22 Desoxypipradrol Hydrochloride (2-DPMP HCl) 10 mg

N H x HCl

LGCFOR0033.00 Dextromethorphan HBr N 10 mg

x HBr x H2O

CERD-013 Dextromethorphan (1.0 mg/ml) CH3O 1 mL in Methanol

NCH 3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERD-034 Dextrorphan tartrate (1.0 mg/ml) (as free base) 1 mL in Methanol

CERD-041 Dextrorphan-D3 (0.1 mg/ml) 1 mL in Methanol

CERD-071 Dextromethorphan-D3 (0.1 mg/ml) 1 mL in Methanol

O OH LGCFOR0435.02 Diacetolol Hydrochloride H 10 mg O N O x HCl

N H NMIAD699 N-Diacetylnorcodeine MeO 5 mg

O NAc H AcO LGCFOR0023.00 Diazepam [Controlled Substance] O 10 mg N

Cl N

CERD-907 Diazepam (1.0 mg/ml) Cl 1 mL in Methanol

N CH 3 N O

CERD-902 Diazepam-D5 (0.1 mg/ml) Cl 1 mL in Methanol D D

D NCH 3 N DD O

CERD-910 Diazepam-D5 (1.0 mg/ml) Cl 1 mL in Methanol D D

D N CH3 N DD O LGCFOR0006.00 Diclofenac Sodium ONa 10 mg O NH Cl Cl

CERD-028 Diclofenac sodium Cl 250 mg O H N + Na -O Cl

LGCFOR1275.18 Diclofensine Hydrochloride 10 mg N

Cl x HCl

O Cl TRC-D440960 Didesethylchloroquine 1 mg LGCFOR0991.03 Didesmethylsibutramine Hydrochloride 10 mg

x HCl

NH2 Cl

104 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR0007.08 N,O-Didesmethyltramadol Hydrochloride HO 10 mg OH x HCl N H

and enantiomer TRC-D444785 Diethylpropion HCl (Amfepramon HCl, Diethylcathinone HCl) 1 g CERD-050 Diethylpropion HCl (1.0 mg/ml) (as free base) 1 mL (Amfepramon HCl) in Methanol

CERD-059 Diethylpropion-D10 HCl (0.1 mg/ml) (as free base) in Methano 1 mL

TRC-D444787 rac Diethylpropion-D10 HCl 1 mg NMIAD675 N,N-Diethyltryptamine 20 mg

CERD-067 Digitoxin (1.0 mg/ml) 1 mL in Methanol

LGCFOR0212.00 Digoxin O O 10 mg OH

OH OO H

OO OH

OO OH HO OH

O OH O H C CH CH CERD-029 Digoxin (1.0 mg/ml) 3 3 3 1 mL O O H3C O O in Methanol H3C O O HO HO HO HO HO

NMIAD823 Dihydrocodeine hydrogen tartrate OH3C 50 mg

O H CH N 3 .C4H6O6 OH CERD-019 Dihydrocodeine HCl (1.0 mg/ml) (as free base) O 1 mL H3C in Methanol

O N CH3

HO HCl

CERD-021 Dihydrocodeine-D6 HCl (0.1 mg/ml) CD3O 1 mL in Methanol

N CD3

HO HCl CERD-033 Dihydromorphine (1.0 mg/ml ) HO 1 mL in Methanol

O N CH3

HO CERH-090 1alpha, 25-Dihydroxyvitamin D2 (5 μg/ml ) 1 mL in Ethanol

CERH-089 1alpha, 25-Dihydroxyvitamin D3 (5 μg/ml ) 1 mL in Ethanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0068.00 Diltiazem HCl O 10 mg

S O N O O

x HCl N

CERD-035 Diltiazem HCl (1.0 mg/ml) (as free base) 1 mL in Acetonitrile

LGCFOR0599.00 Dimenhydrinate O 10 mg H N N x Cl N O O N N

LGCFOR1275.08 Dimethocaine Hydrochloride O 10 mg O N

H2N

NMIAD453 (±)-3,4-Dimethoxyamphetamine HCl H3CO CH3 50 mg

NH2.HCl H3CO NMIAD749 (±)-2,5-Dimethoxyamphetamine HCl OMe 50 mg CH3

NH2 .HCl OMe NMIAD922 2,5-Dimethoxy-4-iodo-phenylethylamine HCl (2-CI) OMe 10 mg NH2 HCl I OMe NMIAD470 (±)-2,5-Dimethoxy-4-methylamphetamine HCl (DOM) OMe 10 mg

HCl NH2

OMe NMIAD885 1,2-Dimethoxy-4-(2-propenyl)-benzene MeO 25 mg

MeO

NMIAD919 2,5-Dimethoxy-4-propylthio-phenylethylamine HCl (2-CT-7) H3CO NH2 5 mg .HCl S OCH3

NMIAD693 (-)-N,N-Dimethylamphetamine HCl CH3 20 mg H NMe2 . HCl

LGCFOR1275.12 Dimethylamylamine Hydrochloride (4-Methyl-2-hexanamine NH2 10 mg Hydrochloride, DMAA HCl) x HCl

LGCFOR1275.30 Dimethylcathinone Hydrochloride (N,N-Dimethylcathinone O 10 mg N Hydrochloride, Metamfepramone Hydrochloride) x HCl

O LGCFOR1275.42 3,4-Dimethylmethcathinone Hydrochloride (3,4-DMMC HCl) H 10 mg N x HCl

NMIAD503 (±)-N,N-Dimethyl-3,4-methylenedioxy-amphetamine HCl .HCl 20 mg O N

O NMIAD674 N,N-Dimethyltryptamine 20 mg NMe2

N H LGCFOR0490.00 Diphenhydramine HCl 10 mg

x HCl N O

106 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

CH3 CERD-015 Diphenhydramine HCl (1.0 mg/ml) HCl 1 mL N in Methanol O CH3

CERD-017 Diphenhydramine-D3 (0.1 mg/ml) CH3 1 mL N in Methanol O CD3

LGCFOR0490.01 Diphenhydramine N-Oxide 10 mg

O N O

LGCFOR0557.00 Diphenylpyraline HCl 10 mg O x HCl N

CERD-054 Disopyramide (1.0 mg/ml) 1 mL in Methanol

NMIAD396 DOB ((±)-4-Bromo-2,5-dimethoxyamphetamine HCl OMe 20 mg CH3 (Brolamfetamin) NH2 .HCl Br OMe O LGCFOR0107.00 Domperidone NH 10 mg

N HN Cl N N

O CERD-081 Dopamine HCl (1.0 mg/ml) (as free base) 1 mL in Methanol with 5% 1 M HCl

CERD-072 Dopamine-D4 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol (with 5% 1 M HCl)

LGCFOR0510.00 Dosulepin HCl (Dothiepin) N 10 mg

x HCl

CERD-908 Dothiepin (cis/trans) (1.0 mg/ml) S 1 mL in Methanol

CH 3 CH CH 2 CH 2 N CH 3

LGCFOR0032.00 Doxepin Hydrochloride N 10 mg

x HCl O

CERD-060 Doxepin-D3 HCl (cis/trans) (0.1 mg/ml) (as free base) 1 mL in Methanol

CERD-051 Doxylamine-D5 (0.1 mg/ml) 1 mL in Acetonitrile

LGCFOR0101.00 Doxylamine Hydrogen Succinate O 10 mg OH N N x O OH

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR1294.00 Dronedarone Hydrochloride O 10 mg

O N x HCl NH O S O OH LGCFOR1122.00 Duloxetine Hydrochloride H 10 mg N x HCl

CERD-044 Duloxetine HCl (1.0 mg/ml) 1 mL in Methanol

CERD-068 Duloxetine-D3 HCl

NMIAD746 Ecgonine HCl H C .HCl 50 mg 3 N COOH H

OH H

CERE-004 Ecgonine HCl (1.0 mg/ml) CH 3 1 mL in Methanol HCl N COOH H

CERE-003 Ecgonine-D3 HCl (0.1 mg/ml) CD 3 1 mL in Methanol HCl N COOH H

CERE-019 Ecgonine ethyl ester (1.0 mg/ml) CH 3 1 mL COOCH CH in Acetonitrile N 2 3 H

CERE-008 Ecgonine methyl ester (0.1 mg/ml) CH 3 1 mL in Acetonitrile N COOCH 3 H

CERE-001 Ecgonine methyl ester (1.0 mg/ml) CH 3 1 mL in Acetonitrile N COOCH 3 H

CERE-002 Ecgonine methyl ester-D3 (0.1 mg/ml) CD 3 1 mL in Acetonitrile N COOCH 3 H

H CERE-006 EDDP perchlorate (as salt) 10 mg

+ H 3 C N CH 2 CH CH 3 3

ClO4

108 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERE-005 EDDP-D3 perchlorate (as salt) 5 mg

+ H3C N CH2CD3

CH3

ClO 4

CERE-022 EDDP perchlorate (1.0 mg/ml) 1 mL in Methanol

+ H3C N CH 2

CH3 CH3

ClO4 CERE-012 EDDP perchlorate (0.1 mg/ml) 1 mL in Methanol

+ H3C N CH 2

CH3 CH3

ClO4 CERE-062 EDDP-D3 perchlorate (1.0 mg/ml) (as pyrrolinium) 1 mL in Methanol

CERE-021 EDDP-D3 perchlorate (0.1 mg/ml) 1 mL in Methanol

+ H3C N CH2CD3

CH3

ClO 4

TRC-E425000 Efavirenz 10 mg TRC-E425002 rac-Efavirenz-D4 1 mg CERE-057 EMDP HCl (1.0 mg/mL) (as free base) (2-Ethyl-5-methyl- 1 mL 3,3-diphenylpyrroline) in Methanol

TRC-E525000 Emtricitabine 10 mg TRC-E525002 Emtricitabine-13C,15N2 0.5 mg NMIAM723 (+)-Ephedrine hemihydrate - DRUG PRECURSOR OH 100 mg CH 3 0.5 H2O MeHN NMIAM924 (-)Ephedrine HCl - DRUG PRECURSOR OH 100 mg

NH.HCl OH LGCFOR0652.00 Ephedrine Hydrochloride DRUG PRECURSOR H 10 mg N x HCl

CERE-011 1S,2R(+)-Ephedrine HCl (1.0 mg/ml) (as free base) H 1 mL H in Methanol - DRUG PRECURSOR C CH C 3 OH NHCH3

HO H CERE-023 1R,2S(-)-Ephedrine HCl (1.0 mg/ml) H 1 mL C NHCH in Methanol - DRUG PRECURSOR C 3

CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERE-025 1S,2R (+)-Ephedrine-D3 HCl (0.1 mg/ml) H 1 mL H in Methanol C CH C 3 OH NHCD3 HCl

CERE-026 1S,2R (+)-Ephedrine-D3 HCl (1.0 mg/ml) H 1 mL H in Methanol C CH C 3 OH NHCD3 HCl

LGCFOR1147.00 Ephedrine Sulphate OH 10 mg H N x H2SO4

CERE-024 R(-)-Epinephrine HO H 100 mg HO C CH2

NHCH3 HO LGCFOR0323.03 Epitestosterone OH 10 mg

O CERE-901 Estazolam (1.0 mg/ml) Cl 1 mL in Methanol

N N N N

CERE-903 Estazolam-D5 (0.1 mg/ml) Cl 1 mL in Methanol DD

D N N N D D N LGCFOR0300.00 Estradiol Hemihydrate OH 10 mg

x 1/2 H2O

HO LGCFOR0130.00 Estriol OH 10 mg

HO CERE-074 Estriol (1.0 mg/ml) 1 mL in Methanol

LGCFOR0282.00 Estrone O 10 mg

HO CERE-075 Estrone (1.0 mg/ml) 1 mL in Methanol

OH NMIAM880 Etilephrine HCl H 50 mg HO N CH3

NMIAD753 (±)-N-Ethylamphetamine HCl CH3 50 mg

NHCH2CH3 .HCl CERE-018 (±)-N-Ethylamphetamine (1.0 mg/ml) H H 1 mL

in Methanol C C NH CH 2 CH 3

H CH 3

110 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit NMIAD938 N-Ethylcathinone HCl O 10 mg CH3

HN HCl O LGCFOR1275.63 beta-Ethylmethcathinone Hydrochloride H 10 mg N x HCl

CERE-016 Ethyl beta-D-glucuronide (0.1 mg/mL) O 1 mL

in Methanol O O CH3 HO

HO OH OH CERE-015 Ethyl-beta-D-glucuronide (1.0 mg/mL) 1 mL in Methanol

CERE-063 Ethyl-beta-D-glucuronide-D5 (1.0 mg/ml) 1 mL in Methanol

CD CERE-048 Ethyl beta-D-glucuronide-D5 (0.1 mg/mL) HOOC O O 3 1 mL in Methanol CD2

HO OH OH

CERE-052 Ethylmorphine (1.0 mg/mL) H3C O 1 mL in Methanol

O N CH3

HO TRC-E925340 Ethylone 5 mg TRC-E925342 Ethylone-D5 1 mg O LGCFOR1275.02 Ethylone Hydrochloride H 10 mg N O x HCl

O CERE-071 Ethylone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERE-072 Ethylone-D5 HCl (0.1 mg/ml) (as free base) 1 mL

LGCFOR0750.00 Ethosuximide H 10 mg O N O

CERE-067 Ethosuximide (1.0 mg/ml) 1 mL in Methanol CERE-064 Ethyl sulfate sodium salt (1.0 mg/ml)(as ethyl sulfate) 1 mL in Methanol CERE-066 Ethyl-D5 sulfate sodium salt (1.0 mg/mL) (as ethyl sulfate) 1 mL in Methanol

CERE-076 17a-Ethynylestradiol (1.0 mg/ml) 1 mL in Methanol

NMIAD543 Fenetylline HCl CH3 20 mg O N H H3C N N .HCl

O N N

CH3 H LGCFOR0608.00 Fenfluramine Hydrochloride N 10 mg x HCl

F F F

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERF-009 Fenfluramine (1.0 mg/ml) CH3 1 mL

in Methanol CH2 CH NH CH2CH3

CF3

CERF-010 Fenfluramine-D10 (0.1 mg/ml) H D 1 mL

in Methanol C C NH CD2CD3

D CD3

CF3

NMIAD918 Fentanyl base O N 20 mg N

LGCFOR0528.00 Fentanyl 10 mg O N

CERF-002 Fentanyl (0.1 mg/ml) O N 1 mL H3C in Methanol N

CERF-013 Fentanyl (1.0 mg/ml) O N 1 mL

H3C in Methanol N

CERF-001 Fentanyl-D5 (0.1 mg/ml) O N 1 mL in Methanol H3C N D D

D D D TRC-F274990 Fentanyl citrate 10 mg

O NMIAD882 Flunitrazepam N 25 mg

O2N N

LGCFOR0069.00 Flunitrazepam O 10 mg N

O2N N

CERF-907 Flunitrazepam (1.0 mg/ml) O2N 1 mL in Methanol

N CH3 N F O

CERF-915 Flunitrazepam-D7 (0.1 mg/ml) O2N 1 mL

in Methanol D D

D N CD3 N O D F

LGCFOR0741.02 4-Fluoroamphetamine HCl NH2 10 mg x HCl F NMIAD854 p-Fluorococaine HCl Me O 20 mg N OMe F H O

H O TRC-F588480 p-Fluoro fentanyl 1 mg TRC-F588482 p-Fluoro fentanyl-D3 1 mg

112 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit O LGCFOR1275.64 2-Fluoromethcathinone Hydrochloride (1-(2-Fluorophenyl)- H 10 mg N 2-(methylamino)propan-1-one Hydrochloride) x HCl

F O LGCFOR1275.43 3-Fluoromethcathinone Hydrochloride (1-(3-Fluorophenyl)- H 10 mg 2-(methylamino)propan-1-one Hydrochloride) F N x HCl

O NMIAD947 3-Fluoromethcathinone HCl H .HCl 20 mg F N

O LGCFOR1275.33 Flephedrone Hydrochloride (4-Fluoromethcathinone Hydrochloride) H 10 mg N x HCl

F LGCFOR1275.17 AM-694 (1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole) O I 10 mg

F LGCFOR1275.13 4-Fluorotropacocaine (3-Pseudotropyl 4-Fluorobenzoate, 3beta-(p- H 10 mg O H Fluorobenzoyloxy)tropane) N O

F H H LGCFOR0256.00 Fluoxetine HCl O N 10 mg

F x HCl F F

CERF-918 Fluoxetine HCl (1.0 mg/mL) (as free base) ONH 1 mL CH in Methanol 3

F3C HCl

D H CERF-919 Fluoxetine-D6 oxalate (0.1 mg/mL) (as free base) ON 1 mL in Methanol CH3 D D COOH F3C COOH D D

D LGCFOR0959.00 Fluoxymesterone OH 10 mg HO

F O

CERF-909 Fluoxymesterone (1.0 mg/mL) H3C OH 1 mL in Dimethoxyethane HO H3C F CH3

O TRC-F597950 cis-(Z)-Flupentixol bromide, dihydrobromide 1 mg TRC-F597960 trans-(E)-Flupentixol bromide dihydrobromide 1 mg TRC-F598000 cis-(Z)-Flupentixol bromide, methanethiosulfonate 1 mg TRC-F598010 trans-(E)-Flupentixol bromide methanethiosulfonate 0.25 mg LGCFOR0114.00 Fluphenazine Dihydrochloride 10 mg

N N S N x 2 HCl OH F

F F CERF-903 Fluphenazine (1.0 mg/ml) 1 mL in Methanol CH2CH2CH2 NNCH2CH2OH

N CF3 2 HCl

CERF-003 Flurazepam (1.0 mg/ml) Cl 1 mL in Methanol

C 2 H 5 N CH 2 CH 2 N N C 2 H 5 F O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

NMIAD447 N-Formylamphetamine CH3 50 mg NHCHO NMIAD465 N-Formyl-di-(1-isopropylphenyl)amine (N-Formyl DPIA) OH 20 mg N H H3C CH3

NMIAD502 N-Formyl-N-methylamphetamine CH3 20 mg

N H H3C O NMIAD498 (±)-N-Formyl-3,4-methylenedioxyamphetamine O CH3 50 mg NHCHO O

NMIAD538 N-Formyl-N-methyl-3,4-methylenedioxyamphetamine O CH3 50 mg

O N H3C CHO NMIAD857 N-Formylnorcocaine O 10 mg H O N OMe H O Ph

H O

NMIAD526 N-Formyl-1-phenylethylamine CH3 50 mg NH

H O TRC-F727250 Fosamprenavir calcium salt 1 mg LGCFOR0014.00 Furosemide OOH 10 mg H N O

H2N S O O Cl CERF-005 Furosemide (1.0 mg/ml) COOH 1 mL

in Methanol NH CH 2 O O

H 2 N S O Cl CERG-007 Gabapentin (1.0 mg/mL) O 1 mL in Methanol NH2 HO

CERG-901 Gabapentin-D10 (0.1 mg/ml) 1 mL in Methanol

LGCFOR1275.51 Gammabutyrolactone (GBL) O 10 mg

CERB-018 gamma-Butyrolactone (1.0 mg/ml) O O 1 mL in Acetonitrile

CERB-032 gamma-Butyrolactone-D6 (1.0 mg/ml) D 1 mL O O in Acetonitrile D D D D D CERG-011 Gentamicin sulfate (1.0 mg/ml) 1 mL in water

NMIAD812 GHB (gamma-Hydroxybutyric acid sodium salt) O 50 mg HO ONa

CERG-001 GHB (4-Hydroxybutyric acid sodium salt) (1.0 mg/ml) (as salt) O 1 mL

- + in Methanol HO CH2 CH2 CH2 CO Na

114 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERG-003 GHB-D6 (4-Hydroxy-2,2,3,3,4,4-hexadeuterobutyric acid sodium O 1 mL - + salt) (0.1 mg/ml) (as salt) HO CD2 CD2 CD2 C O Na in Methanol

CERG-006 GHB-D6 (4-Hydroxy-2,2,3,3,4,4-hexadeuterobutyric acid sodium O 1 mL - + salt) (1.0 mg/ml) (as salt) HO CD2 CD2 CD2 C O Na in Methanol

LGCFOR0582.00 Griseofulvin Cl O 10 mg O O O

O O

CERH-089 1alpha, 25-Dihydroxyvitamin D3 (5 μg/ml ) 1 mL in Ethanol

CERG-005 Glutethimide (1.0 mg/ml) H 1 mL in Methanol O NO CH3 CH2

CERH-030 Haloperidol (1.0 mg/ml) O OH 1 mL in Methanol F C N

Cl CERH-002 Haloperidol-D4 (0.1 mg/ml) DD 1 mL O OH in Methanol F C N

D D

NMIAD884 Harmine H CH3 10 mg N H CO 3 N

NMIAD752 Heroin base AcO 50 mg

O N

CH3 AcO CERH-038 Heroin (1.0 mg/ml) O 1 mL in Acetonitrile CH3 C O

N CH3 O

CH3 C O

CERH-036 Heroin-D9 (0.1 mg/ml) O 1 mL in Acetonitrile CD3 C O

N CD3 O

CD3 C O

CERH-037 Heroin-D9 (1.0 mg/ml) O 1 mL

in Acetonitrile CD3 C O

N CD3 O

CD3 C O

CERH-013 Hexobarbital (1.0 mg/ml) CH3 1 mL in Methanol O N OH

H3C N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR1275.49 Hordenine Hydrochloride (4-Hydroxy-N,N- 10 mg N dimethylphenethylamine Hydrochloride) x HCl

HO CAY-90082 HU-210 (1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol) 5 mg CAY-10005673 HU-331 - 3-hydroxy-2-((1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl) 5 mg -5-pentyl-2,5-cyclohexadiene-1,4-dione) LGCFOR0011.00 Hydrochlorothiazide O O O O 10 mg S S H2N NH

Cl N H CERH-001 Hydrochlorothiazide (1.0 mg/ml) O O 1 mL NH 2 SO 2 S in Methanol NH

Cl N H

CERH-003 Hydrocodone (1.0 mg/ml) CH3O 1 mL in Methanol

NCH3

CERH-005 Hydrocodone-D3 (0.1 mg/ml) CH3O 1 mL in Methanol

N CD3

CERH-008 Hydrocodone-D3 (1.0 mg/ml) CH3O 1 mL in Methanol

N CD3

CERH-047 Hydrocodone-D6 (0.1 mg/ml) CD3O 1 mL in Methanol

N CD3

CERH-048 Hydrocodone-D6 (1.0 mg/ml) cd3o 1 mL in Methanol

N CD3

NMIAD785 Hydromorphone HCl HO 20 mg

O H NMe HCl O CERH-004 Hydromorphone (1.0 mg/ml) HO 1 mL in Methanol

NCH 3

CERH-006 Hydromorphone-D3 (0.1 mg/ml) HO 1 mL in Methanol

N CD3

116 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERH-010 Hydromorphone-D3 (1.0 mg/ml) HO 1 mL in Methanol

N CD3

O CERH-078 Hydromorphone-D4 (0.1 mg/ml) 1 mL in Methanol

CERH-049 Hydromorphone-D6 (0.1 mg/ml) HO 1 mL in Methanol D D D O

N CD3

O CERH-050 Hydromorphone-D6 (1.0 mg/ml) 1 mL in Methanol

O CERH-051 Hydromorphone-3beta-D-glucuronide (0.1 mg/mL) HOOC O 1 mL in Methanol/Water HO OH O HO N CH3 O LGCFOR0185.00 Hydrocortisone (Cortisol) O 10 mg OH HO OH

O LGCFOR0062.05 10-Hydroxyamitriptyline 10 mg N

CERA-905 alpha-Hydroxyalprazolam (0.1 mg/ml) Cl 1 mL in Methanol

CH2OH N N N N

CERA-907 alpha-Hydroxyalprazolam (1.0 mg/ml) Cl 1 mL in Methanol

CH 2 OH N N N N

CERA-904 alpha-Hydroxyalprazolam-D5 (0.1 mg/ml) Cl 1 mL in Methanol D D

CH 2 OH D N N N DD N

CERA-908 alpha-Hydroxyalprazolam-D5 (1.0 mg/ml) Cl 1 mL in Methanol D D

CH2OH D N N N DD N

NMIAD824 (±)-4-Hydroxyamphetamine HCl (HMA) CH3 20 mg

NH .HCl HO 2

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERH-017 m-Hydroxybenzoylecgonin (1.0 mg/ml) CH 3 1 mL in Methanol N COOH H OH O

OC H CERH-066 (±)-Hydroxybupropion (1.0 mg/ml) 1 mL in Acetonitril

CERH-062 (±)-Hydroxybupropion-D6 (0.1 mg/ml) 1 mL in Acetonitrile

TRC-H916900 Hydroxychloroquine sulphate 10 mg LGCFOR0764.00 Hydroxychloroquine sulphate Cl N 10 mg x H2SO4

HN OH N

CERH-063 6-Hydroxychlorzoxazone (0.1 mg/ml) 1 mL in Methanol

CERH-064 6-Hydroxychlorzoxazone-D2,15N (0.1 mg/ml) 1 mL in Methanol

TRC-H924500 trans-3'-Hydroxycotinine 10 mg TRC-H924510 trans-3'-Hydroxycotinine methyl-D3 1 mg CERH-060 7-Hydroxycoumarin (1.0 mg/ml) 1 mL in Acetonitrile

CERH-061 7-Hydroxycoumarin-13C6 (0.1 mg/ml) 1 mL in Acetonitrile

CERH-052 4'-Hydroxydiclofenac (0.1 mg/ml) 1 mL in Acetonitrile

CERH-053 4'-Hydroxydiclofenac-13C6 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0076.10 10-Hydroxy-10,11-dihydrocarbamazepine Cl N 10 mg x H2SO4

HN OH N

TRC-H941825 rac 8-Hydroxy efavirenz 1 mg TRC-H941827 rac 8-Hydroxy efavirenz-D4 1 mg CERF-901 2-Hydroxyethylflurazepam (0.1 mg/ml) Cl 1 mL in Methanol

N CH2 CH2 OH N F O

118 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERF-902 2-Hydroxyethylflurazepam (1.0 mg/ml) Cl 1 mL in Methanol

N CH2 CH2 OH N F O

CERH-919 2-Hydroxyethylflurazepam-D4 (0.1 mg/ml) Cl 1 mL

in Methanol D D

D N CH2 CH2 OH N D F O CERH-923 2-Hydroxyethylflurazepam-D4 (1.0 mg/ml) 1 mL in Methanol

TRC-H942400 beta-Hydroxyfentanyl HCl 1 mg TRC-H942402 beta-Hydroxyfentanyl-d3 HCl 1 mg LGCFOR0077.04 10-Hydroxyimipramine BH3-Aduct 10 mg

N N x BH3

HO CERH-093 5-Hydroxyindole-4,6,7-D3-3-acetic-D2 Acid (5-HIAA-D5) (1.0 mg/ml) 1 mL in Methanol

CERH-077 4-Hydroxymephenytoin (0.1 mg/mL) 1 mL in Methanol

CERH-902 alpha-Hydroxymidazolam (0.1 mg/ml) Cl 1 mL in Methanol

CH2OH N N N F CERH-922 alpha-Hydroxymidazolam (1.0 mg/mL) 1 mL in Methanol

CERH-921 alpha-Hydroxymidazolam-D4 (0.1 mg/ml) Cl 1 mL D in Acetonitrile D

D OH

D N N F TRC-H948625 2-Hydroxynevirapine 2.5 mg CERH-918 4-Hydroxynordiazepam (1.0 mg/ml) Cl 1 mL in 1,2-Dimethoxyethane

HO NH N O CERH-081 7-Hydroxyquetiapine (1.0 mg/ml) 1 mL in Methanol

TRC-H953225 7-Hydroxyquetiapine 1 mg TRC-H953227 7-Hydroxyquetiapine-D3 1 mg

OH LGCFOR0491.03 9-Hydroxyrisperidone N 10 mg

N F N O

NO CERH-076 9-Hydroxyrisperidone (1.0 mg/ml) 1 mL in Methanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERH-085 17alpha-Hydroxyprogesterone (1.0 mg/ml) 1 mL in Methanol

CERH-026 11-hydroxy-delta 9-THC (0.1 mg/ml) CH2OH 1 mL in Methanol OH

H 3 C

H 3 C O CH 3

CERH-027 11-hydroxy-delta 9-THC (1.0 mg/ml) HO 1 mL in Methanol OH

CERH-041 11-hydroxy-delta 9-THC-D3 (0.1 mg/ml) CH2OH 1 mL in Methanol OH

H3C H C O 3 CD3

CERH-054 4-Hydroxytolbutamide (1.0 mg/ml) 1 mL in Acetonitrile

CERH-055 4-Hydroxytolbutamide-D9 (0.1 mg/ml) 1 mL in Acetonitrile

CERT-915 alpha-Hydroxytriazolam (0.1 mg/ml) Cl 1 mL in Methanol

CH 2 OH N N N Cl N

CERT-911 alpha-Hydroxytriazolam (1.0 mg/ml) Cl 1 mL in Methanol

CH 2 OH N N N Cl N CERT-916 alpha-Hydroxytriazolam-D4 (1.0 mg/ml) 1 mL in Methanol

CERT-909 alpha-Hydroxytriazolam-D4 (0.1 mg/ml) Cl 1 mL in Methanol D D

CH 2 OH D N N N D Cl N CERH-073 25-Hydroxyvitamin D2 (0.05 mg/ml) 1 mL in Ethanol

CERH-087 25-Hydroxyvitamin D2 (5 μg/ml ) 1 mL in Ethanol

CERH-074 D6-25-Hydroxyvitamin D3 (26,26,26,27,27,27-D6) (0.05 mg/mL) 1 mL in Ethanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERH-086 25-Hydroxyvitamin D3 (5 μg/ml) 1 mL in Ethanol

CERH-083 25-HydroxyvVitamin D3 (1.0 mg/ml) 1 mL in Ethanol

Cl O LGCFOR0852.00 Hydroxyzine Hydrochloride N OH 10 mg N x 2 HCl

CERI-001 Ibogaine (1.0 mg/ml) H3CO 1 mL N in Methanol N H CH2CH3

LGCFOR0002.00 Ibuprofen 10 mg OH

CERI-009 Ibuprofen (1.0 mg/ml) CH3 1 mL in Methanol OH CH3 O H3C LGCFOR0076.06 Iminodibenzyl (10,11-Dihydro-5H-dibenzo[b,f]azepine) 10 mg

TRC-I465200 Imipenem monohydrate 10 mg LGCFOR0077.00 Imipramine Hydrochloride 10 mg

N N x HCl

CERI-902 Imipramine HCl (1.0 mg/ml) 1 mL

in Methanol N CH 3

CH 2 CH 2 CH 2 N

CH 3 LGCFOR0077.12 Imipramine N-Oxide 10 mg

N N O

TRC-I525000 Indinavir sulphate 5 mg TRC-I525006 Indinavir sulphate-D6 1 mg

LGCFOR1275.78 5-Iodo-2-aminoindane (5-IAI) Hydrochloride NH2 x HCl 10 mg I CERI-010 iso-LSD (iso-Lysergic acid diethylamide) (0.1 mg/ml) 1 mL in Acetonitrile

CAY-10266 JWH-007 5 mg RCG-375-1ML JWH-007 (1.0 mg/ml) 1 ml in Methanol CAY-10660 JWH 015-D7 1 mg CAY-10486 JWH 007-D9 1 mg LGCFOR1275.72 JWH-015 ((2-Methyl-1-propylindol-3-yl)(naphthalen-1-yl)methanone) 10 mg

CAY-10009018 JWH-015 5 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

NMIAD955 JWH-018 ( N-Pentyl-3-(1-naphthoyl)indole) O 20 mg

N C5H11 THC-1185 JWH-018 (Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanon) 10 mg TRC-P283652 JWH-018-D11 (1-(Pentyl-d11)-3-(1-naphthoyl)indole) 1 mg CERS-025 JWH-018 (Spice Cannabinoid) (0.1 mg/ml) 1 mL THC-1185M JWH-018 (Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanon) (1 mg/ mL) 1 mL in Methanol CAY-9000855 JWH 018 - N-(5-hydroxypentyl) metabolite 1 mg (solution in ethanol) CAY-13824 JWH 018-D9 (1 mg/ml) 1 mg in Methanol CAY-10697 JWH 018 6-methoxyindole analog 1 mg (solution) CAY-9000851-5 JWH 018 4-hydroxyindole metabolite CAY-9000856 JWH 018 N-pentanoic acid metabolite 1 mg THC-1244 JWH-019 (1-Hexyl-1H-indol-3-yl)(naphthalen-1-yl)methanon 5 mg THC-1216 JWH-019 ((1-Hexyl-1H-indol-3-yl)(naphthalen-1-yl)methanon) (1mg / mL) 1 mL in Methanol THC-1215 JWH-073 ((1-Butyl-1H-indol-3-yl)(naphthalen-1-yl)methanon) (1mg / mL) 1 mL in Methanol CAY-13170 JWH-073 (1-butyl-1H-indol-3-yl)-1-naphthalenyl-methanon 5 mg (25 mg/ml) in Methanol THC-1243 JWH-073 ( (1-Butyl-1H-indol-3-yl)(naphthalen-1-yl)methanon) 5 mg CERS-027 JWH-073 (Spice Cannabinoid) (0.1 mg/ml) 1 mL in Acetonitrile

CERS-037 JWH-073 3-Hydroxybutyl metabolite (0.1 mg/ml) 1 mL in Methanol

CAY-9000861 JWH 073 4-hydroxyindole metabolite 1 mg (solution in Ethanol) CAY-10691 JWH-073 3-methylbutyl homolog 5 mg CAY-9000866 JWH 073 N-butanoic acid metabolite 1 mg RCG-377-50MG JWH-081 RCG-377-1ML JWH-081 (1.0 mg/ml) in Methanol CAY-10511 JWH 081-D9 500 μg LGCFOR1275.66 JWH-122 ((4-Methylnaphthalen-1-yl)(1-pentylindol-3-yl)methanone) 10 mg

THC-1213 JWH-122 (1.0 mg/ml) 1 mL (4-Methylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanon) in Methanol CAY-10512 JWH 122-D9 500 μg

TRC-H297400 JWH-147 (1-Hexyl-2-phenyl-4-(1-naphthoyl)pyrrole) 10 mg

RCG-381-10MG JWH-200 THC-1220 JWH-200 (1.0 mg/ml) 1 mL ((1-(2-Morpholinoethyl)-1H-indol-3-yl)(naphthalen-1-yl)methanon) in Methanol CAY-13171 JWH-200 5 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CAY-10682 JWH 200-D5 1 mg (solution in Acetonitrile) CAY-10721 JWH-201 5 mg (solution in Methyl Acetate) LGCFOR1275.70 JWH-203 (2-(2-Chlorophenyl)-1-(1-pentylindol-3-yl)ethanone) 10 mg

O Cl

THC-1373M JWH-203 (1 mg/ml) 1 mL in Methanol CAY-10644 JWH-210 5 mg THC-1278M JWH-210 (1.0 mg/ml) 1 mL in Methanol CAY-10510 JWH 210-D9 500 μg RCG-380-10MG JWH-250 THC-1214 JWH-250 (1.0 mg/ml) 1 mL (2-(2-Methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanon) in Methanol CAY-10661 JWH 250-D5 1 mg CAY-10578 JWH-251 5 mg CAY-10722 JWH-302 5 mg (solution in Methyl Acetate) CAY-13636 JWH 398 1 mg NMIAD686 (±) Ketamine HCl 50 mg LGCFOR0144.00 Ketamine HCl O 10 mg Cl NH x HCl

CERK-002 Ketamine HCl (1.0 mg/ml) Cl 1 mL O in Methanol

NH HCl

CH3

CERK-003 Ketamine-D4 HCl (0.1 mg/ml) D 1 mL in Methanol Cl D O D

NH D HCl CH3

LGCFOR0180.04 Ketotifen S N 10 mg

LGCFOR0180.00 Ketotifen Hydrogen Fumarate S N 10 mg

CERL-008 LAAM-HCl (1.0 mg/ml) (levo)-a-Acetylmethadol HCl) (as free base) O 1 mL in Methanol H3C O CH3 HCl H3C N CH3 CH3

TRC-L172500 Lamivudine 10 mg TRC-L172502 Lamivudine-15N2,13C 1 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

N NH2 LGCFOR0922.00 Lamotrigine N 10 mg N

NH2 Cl Cl

O CERL-007 LAMPA (25 μg/ml) (Lysergic acid N,N-methylpropylamide) CH 3 1 mL in Acetonitrile N C CH CH CH CH3 3 2 2 N H H

N H

O CERL-004 LAMPA (1.0 mg/ml) (Lysergic acid N,N-methylpropylamide) CH 3 1 mL in Acetonitrile N C CH CH CH CH3 3 2 2 N H H

N H CERL-025 (-)-Levamisole HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

TRC-L331500 Levetiracetam 100 mg CERL-023 Levetiracetam-D6 (0.1 mg/ml) 1 mL in Methanol

O Cl O LGCFOR1035.00 Levocetirizine Dihydrochloride N OH 10 mg N

x 2 HCl

LGCFOR0019.00 Levomepromazine Maleate O 10 mg

N N OH x S OH

O O LGCFOR0019.01 Levomepromazine Sulphoxide 10 mg

N N S O

CERL-010 Levomethorphan CH3O 10 mg

N CH 3

LGCFOR0102.00 Lidocaine H 10 mg N N O CERL-018 Lidocaine (1.0 mg/ml) 1 mL in Methanol

TRC-L469480 Lopinavir 10 mg TRC-L469482 Lopinavir-D8 1 mg TRC-L469485 Lopinavir metabolite M-1 1 mg TRC-L469490 Lopinavir metabolite M-3/M-4 1 mg

O LGCFOR0257.00 Loratadine Cl 10 mg N O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERL-014 Loratadine (1.0 mg/ml) O OCH3 1 mL in Methanol N

H O LGCFOR0071.00 Lorazepam N 10 mg OH Cl N

CERL-901 Lorazepam (1.0 mg/ml) Cl 1 mL in Acetonitrile

N Cl O OH

CERL-902 Lorazepam-D4 (0.1 mg/ml) Cl 1 mL in Acetonitrile D D

D NH N D Cl O OH

CERL-911 Lorazepam-D4 (1.0 mg/mL) Cl 1 mL in Acetonitrile D D

D NH N D Cl O OH CERL-021 Lorazepam glucuronide (0.1 mg/ml) 1 mL 50 : 50 Acetonitrile : Water

CERL-907 Lormetazepam (1.0 mg/ml) Cl 1 mL in Methanol

N CH 3 N Cl O OH THC-1218 LSA (lysergic acid amide) 1 mg O NMIAD827 LSD (9,10-didehydro-N,N-diethyl-6-methylergoline-8-beta-carboxamide) (1 C Amp. Et2N N mg/ml Acetonitrile solution) H

N H

O CERL-005 LSD (Lysergic acid diethylamide) (25 μg/ml) H 5 C 2 1 mL in Acetonitrile N C CH3 H 5 C 2 N H H

N H

O CERL-001 LSD (Lysergic acid diethylamide) (1.0 mg/ml) H 5 C 2 1 mL in Acetonitrile N C CH3 H 5 C 2 N H H

N H

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERL-006 LSD-D3 (Lysergic acid diethylamide-D3) (25 μg/mL) O 1 mL H 5 C 2 in Acetonitrile N C CD 3 H 5 C 2 N H H

O CERL-002 LSD-D3 (Lysergic acid diethylamide-D3) (0.1 mg/ml) H 5 C 2 1 mL in Acetonitrile N C CD 3 H 5 C 2 N H H

N H CERI-010 iso-LSD (iso-Lysergic acid diethylamide) (0.1 mg/ml) 1 mL in Acetonitrile

CERL-017 nor-LSD/ nor-iso-LSD O O 5 mg H 5 C 2 H 5 C 2 N C N C H C 5 2 NH H 5 C 2 NH H H H H

N N H H

O CERO-013 2-Oxo-3-hydroxy-LSD (0.1 mg/ml) H 5 C 2 1 mL in Acetonitrile N C CH3 H 5 C 2 N H H

LGCFOR0820.00 Maprotiline Hydrochloride 10 mg

N H x HCl

CERM-920 Maprotiline HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

TRC-M205502 Mefentanyl -D5* 1 mg TRC-M225620 Meropenem sodium salt 10 mg TRC-M305310 alpha-Methyl fentanyl 1 mg TRC-M305312 alpha-Methyl fentanyl D3 1 mg O NMIAD450A (±)-N-Methyl-1-(3,4-methylenedoxyphenyl)-2-butylamine HCl CH3 20 mg (MBDB) O NHCH3 . HCl

CERM-102 (±)-MBDB HCl ((±)-(3,4-Methylene-dioxyphenyl)-2-butamine) (1.0 H H 1 mL O mg/ml) C C NH CH3 in Methanol H CH CH O 2 3

HCl CERM-104 (±)-MBDB-D5 (±)-(3,4-Methylene-dioxyphenyl)-2-butamine-D5) 1 mL (0.1 mg/ml) H D O in Methanol C CNHCD3 D CH CH O 2 3

126 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit

NMIAD842 (±)-3,4-Methylenedioxyamphetamine HCl (MDA) O CH3 50 mg . HCl O NH2

CERM-012 (±)-MDA ((±)-3,4-Methylenedioxyamphetamine) (1.0 mg/ml) H CH 3 1 mL O (Tenamfetamin) C C NH 2 in Methanol H H O

CERM-010 (±)-MDA-D5 ((±)-3,4-Methylenedioxyamphetamine-D5) (0.1 mg/ml) D CD 3 1 mL O in Methanol CCNH 2 H D O

CERM-027 (±)-MDA-D5 ((±)-3,4-Methylenedioxyamphetamine-D5) (1.0 mg/ml) D CD 3 1 mL O in Methanol CCNH 2 H D O

LGCFOR1275.21 MDAT (6,7-Methylenedioxy-2-aminotetralin) O NH2 10 mg x HCl O LGCFOR1275.80 MDAT HCl (6,7-Methylenedioxy-2-aminotetralin Hydrochloride) O NH2 10 mg x HCl O

NMIAD739 (±)-N-Ethyl-3,4-methylenedioxyamphetamine HCl (MDEA) O CH3 50 mg

O NHEt.HCl

CERM-065 (±)-MDEA ((±)-3,4-Methylenedioxyethylamphetamine) H CH 3 1 mL O (1.0 mg/ml) CCNH CH 2 CH 3 in Methanol H H O

CERM-067 (±)-MDEA-D5 ((±)-3,4-Methylenedioxyethylamphetamine-D5) H CH 3 1 mL O (0.1 mg/ml) CCNH CD 2 CD 3 in Methanol H H O

CERM-068 (±)-MDEA-D5 ((±)-3,4-Methylenedioxyethylamphetamine-D5) H CH 3 1 mL O (1.0 mg/ml) CCNH CD 2 CD 3 in Methanol H H O

CERM-081 (±)-MDEA-D6 ((±)-3,4 Methylenedioxyethylamphetamine-D6) H CD3 1 mL O (0.1 mg/ml) CCNH CH2 CD3 in Methanol H H O

CERM-082 (±)-MDEA-D6 [(±)-3,4-Methylenedioxyethylamphetamine-D6] 1 mL (1.0 mg/ml) in Methanol H .HCl NMIAD792C MDMA HCl (N-Methyl-3,4-methylenedioxyamphetamine HCl) O N 50 mg Purity (mass fraction)...... 99.98 ± 1.5 % O

CERM-013 (±)-MDMA ((±)-3,4-Methylenedioxymethamphetamine) H CH 3 1 mL O (1.0 mg/ml) CCNH CH 3 in Methanol H H O

CERM-011 (±)-MDMA-D5 ((±)-3,4-Methylenedioxymethamphetamine-D5) (0.1 D CH 3 1 mL O mg/ml) CCNH CD 3 in Methanol H D O

CERM-029 (±)-MDMA-D5 ((±)-3,4-Methylenedioxymethamphetamine-D5) (1.0 D CH 3 1 mL O mg/ml) CCNH CD 3 in Methanol H D O

LGCFOR0056.04 Melamine H2NNHN 2 10 mg NN

NH2

CERM-095 Melatonin (1.0 mg/ml) H3CO CH2 CH2 O 1 mL

in Methanol NH C CH3 N

CERM-094 Melatonin-D7 (0.1 mg/ml) H3CO CD2 CD2 O 1 mL

in Methanol NH C CD3 N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR1275.07 5-MeO-DALT (5-Methoxy-N,N-diallyltryptamine) 10 mg N

N H

CERM-035 Meperidine (1.0 mg/ml) CH3 1 mL in Methanol N

COCH2CH3

CERM-036 Meperidine-D4 (0.1 mg/ml) CH 3 1 mL in Methanol N D D

D D

COCH2CH3 O

CERM-038 Meperidine-D4 (1.0 mg/ml) CH 3 1 mL

in Methanol N D D D D COCH2CH3 O

NMIAD443 Meperidine HCl (Pethidine) 20 mg

O N .HCl CERM-138 Mephedrone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERM-139 Mephedrone-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

CERM-039 Meprobamate (1.0 mg/ml) O CH3 O 1 mL

in Methanol NH2 C O CH2 C CH2 O C NH2

CH2 CH2 CH3

CERM-131 Meprobamate-D7 (propyl-D7) (0.1 mg/mL) 1 mL in Methanol

CERM-047 Mescaline HCl (1.0 mg/ml) as free base CH 2 CH 2 NH 2 1 mL in Methanol

CH 3 O OCH 3

OCH 3

CERM-051 Mescaline-D9 HCl (0.1 mg/ml) (as free base) CH 2 CH 2 NH 2 1 mL in Methanol

CD 3 O OCD 3

OCD 3

NMIAD768 Mescaline hydrogen sulfate MeO NH2 10 mg .H SO MeO 2 4 OMe CERM-074 Metaxalone (1.0 mg/mL) 1 mL in Methanol

128 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CERM-143 Metaxalone-D6 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0052.00 Metamizole Sodium Monohydrate O O O 10 mg NS ONa N x H2O N

LGCFOR0056.00 Metformin Hydrochloride NH NH 10 mg x HCl H2NNN H

NMIAD425B Methadone HCl O 20 mg HCl N

CERM-019 (±)-Methadone (0.1 mg/ml) 1 mL in Methanol O CH3 CH3 CH2 C C CH2 CH N CH3 CH3

CERM-007 (±)-Methadone (1.0 mg/ml) 1 mL in Methanol O CH 3 CH 3 CH 2 C C CH 2 CH N CH 3 CH 3

CERM-008 (±)-Methadone-D3 (0.1 mg/ml) 1 mL in Methanol O CH 3 CD 3 CH 2 C C CH 2 CH N CH 3 CH 3

CERM-021 (±)-Methadone-D3 (1.0 mg/ml) 1 mL in Methanol O CH3 CD3 CH2 C C CH2 CH N CH3 CH3

CERM-088 (±)-Methadone-D9 (0.1 mg/ml) 1 mL in Methanol O CD 3 CD 3 CH 2 C C CH 2 CH N CD CH 3 3

CERM-089 (±)-Methadone-D9 (1.0 mg/ml) 1 mL in Methanol O CD3 CD3 CH2 C C CH2 CH N

CH3 CD3

LGCFOR0964.00 Methamphetamine HCl H 10 mg N x HCl

CERM-022 (±)-Methamphetamine (0.1 mg/ml) H CH 3 1 mL

in Methanol C C NH CH 3 H H

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERM-009 (±)-Methamphetamine (1.0 mg/ml) H CH 3 1 mL

in Methanol C C NH CH 3 H H

CERM-024 R(-)-Methamphetamine (1.0 mg/mL) (Levmetamfetamin) NHCH3 1 mL in Methanol CH3

CERM-020 S(+)-Methamphetamine (1.0 mg/ml) H 1 mL CH2 NHCH in Methanol C 3

CH3

CERM-004 (±)--Methamphetamine-D5 (0.1 mg/ml) D CH 3 1 mL

in Methanol C CNHCD 3 H D

CERM-023 (±)-Methamphetamine-D5 (1.0 mg/ml) D CH 3 1 mL

in Methanol C CNHCD 3 H D

CERM-016 (±)-Methamphetamine-D8 (0.1 mg/ml) D CD 3 1 mL

in Methanol C CNHCD 3 H D

CERM-034 (±)-Methamphetamine-D8 (1.0 mg/ml) D CD3 1 mL

in Methanol C C NH CD3 H D

CERM-090 (±)-Methamphetamine-D9 (0.1 mg/ml) D CD3 1 mL

in Methanol C C NH CD3 D D

CERM-091 (±)-Methamphetamine-D9 (1.0 mg/ml) D CD3 1 mL

in Methanol C C NH CD3 D D

CERM-059 (±)-Methamphetamine-D11 (0.1 mg/ml) D D 1 mL in Methanol H CD 3 DCC NH CD 3 H H D D

CERM-060 (±)-Methamphetamine-D11 (1.0 mg/ml) D D 1 mL in Methanol H CD3 D C C NH CD3 H H D D

CERM-092 (±)-Methamphetamine-D14 (0.1 mg/ml) D D 1 mL in Methanol D CD 3 DCC NH CD3 D D D D

CERM-093 (±)-Methamphetamine-D14 (1.0 mg/ml) D D 1 mL in Methanol D CD3 D C C NH CD3 D D D D

CERM-912 Methandienone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CH3 H3C

CERM-015 Methaqualone (1.0 mg/ml) N CH3 1 mL in Methanol N

O H3C

CERM-014 Methaqualone-D7 (0.1 mg/ml) N CH 3 1 mL in Methanol D N D

D 3 C D D TRC-M225925 Methcathinone 10 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit TRC-M225927 Methcathinone-D3 5 mg NMIAD724 (±)-Methcathinone HCl (Ephedron) O 20 mg ( (±)-2-(Methylamino)-1-phenyl-1-propanone HCl) NHMe . HCl CH3

O CERM-061 R(+)-Methcathinone HCl (1.0 mg/mL) (as free base) H 1 mL in Methanol C C CH3

NHCH 3 HCl

O CERM-055 S(-)-Methcathinone HCl (1.0 mg/ml) H 1 mL in Methanol C C NHCH 3

CH3 HCl

O LGCFOR1275.04 Methedrone Hydrochloride H 10 mg N x HCl

O TRC-M260150 Methedrone HCl 5 mg CERM-147 Methedrone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol TRC-M260152 Methedrone-D3 HCl 1 mg

CERM-910 Methenolone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane H3C CH3

O H

CERM-041 Methohexital (1.0 mg/ml) CH 3 1 mL in Methanol OON

CH 2 CH CH 2 N H CH 3 CH 2 C C CH O CH 3

CERM-079 Methohexital-D5 (0.1 mg/ml) CH 3 1 mL in Methanol OON

CD 2 CD CD 2 N H CH 3 CH 2 C C CH O CH 3 CERM-136 Methotrexate (1.0 mg/ml) 1 mL in Methanol with 0.1 N NaOH

LGCFOR1275.65 Methoxetamine Hydrochloride O 10 mg NH O x HCl

NMIAD899 5-Methoxy-alpha-methyltryptamine NH2 10 mg H CO 3 CH3

N H NMIAD954 5-Methoxy-diallyltryptamine 10 mg MeO N

N H NMIAD923 5-methoxy-diisopropyltryptamine HCl 1 mg N OH3C H Cl N H NMIAD952 4'-Methoxymethcathinone HCl (Methedrone) O 20 mg

HN .HCl MeO LGCFOR1247.02 1-(2-Methoxyphenyl)piperazine Dihydrochloride 10 mg x 2 HCl N HN O

LGCFOR0051.05 2-Methoxy-5-sulphamoylbenzamide O O 10 mg H2N S NH O 2 O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR1275.41 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane HN 10 mg Hydrochloride O x HCl

O CERM-045 Cis-(±)-4-Methylaminorex (1.0 mg/ml) HH 1 mL

in Acetonitrile CH3 NO

NH2 NMIAD816 (±)-Methylamphetamine hydrochloride HCl HN

NMIAD895 (±)-4-Methylamphetamine HCl CH3 10 mg

NH2 . HCl H3C

NMIAD830 (±)-S-Methylamphetamine HCl CH3 50 mg H NHCH3 .HCl

LGCFOR0586.07 N-(3-Methylbenzyl)piperazine DiHCl N 10 mg x 2 HCl HN LGCFOR1275.44 2-Methyl-2-butanol 10 mg OH NMIAD924 Methyl codeine CH3O 10 mg

O N

CH3 CH3O

NMIAD452 Methyl ecgonine HCl monohydrate N O HCl 50 mg OMe

OH LGCFOR1275.05 5,6-Methylenedioxy-2-aminoindane (MDAI) O 10 mg NH2 O

LGCFOR1275.60 3,4-Methylenedioxy-N-benzylcathinone Hydrochloride O 10 mg H O N x HCl

O NMIAD890 3,4- Methylenedioxybenzyl methyl ketoximine O 10 mg

O N OH O NMIAD942 3,4-Methylenedioxymethcathinone HCl H .HCl 20 mg N O Me O Me TRC-M303962 Methylenedioxymethcathinone-D3 HCl 1 mg NMIAD810 3,4-Methylenedioxyphenylacetone (MDP2P) - DRUG PRECURSOR O 20 mg

O O

NMIAD669 1-(3,4-Methylenedioxyphenyl)-2-nitropropene O NO2 20 mg

O CH3 NMIAD880 (R,S)-1-(3,4-Methylenedioxyphenyl)-propan-2-ol O 10 mg O OH NMIAD896 bis-(1-(3,4-Methylenedioxyphenyl)-propan-2-yl)amine HCl (1 H 20 mg O N O diastereoisomer) O O HCl NMIAD879 bis-(1-(3,4-Methylenedioxyphenyl)-propan-2-yl)amine HCl H 20 mg N (mix of isomers) O O O O HCl LGCFOR1275.61 3',4'-Methylenedioxy-alpha-pyrrolidinobutiophenone Hydrochloride O 10 mg (MDPBP HCl) O N x HCl

O NMIAD960 (+/-)-3,4-Methylenedioxy-alpha-pyrrolidinopropiophenone HCl O 20 mg O .HCl O N

TRC-M304080 Methylenedioxypyrovalerone HCl 10 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit TRC-M304082 Methylenedioxypyrovalerone-D8 HCl 1 mg NMIAD951 3,4-Methylenedioxypyrovalerone HCl O 20 mg O

O N .HCl CERM-146 3,4-Methylenedioxypyrovalerone HCl (MDPV) (1.0 mg/mL) (as free O 1 mL base) O

in Methanol O N .HCl

NMIAD887 3,4-Methylenedioxytoluene O CH3 10 mg

O NMIAM243 (-)-Methylephedrine HCl OH HCl 20 mg CH3 N CH3 CH3 CERM-129 Methylephedrine (1.0 mg/ml) 1 mL in Methanol

O LGCFOR1275.20 Methylethcathinone Hydrochloride (4-Methyl-N- H 10 mg N ethylcathinone Hydrochloride, 4-MEC HCl) x HCl

CERM-080 Methylmalonic acid (1.0 mg/ml) 1 mL in Acetonitrile

CERM-105 Methyl-D3-malonic acid (1.0 mg/ml) 1 mL in Acetonitrile

NMIAD937 (±)-4'-Methylmethcathinone HCl (Mephedrone) O 10 mg

HN .HCl CH3 TRC-M224202 4-Methylmethcathinone-D3 HCl (Mephedrone-D3 HCl) 1 mg

NMIAD883 N-Methyl-3,4-methylenedioxybenzylamine HCl O N 20 mg H O HCl

H O NMIAD903 2-Methyl-3-(3,4-methylenedioxyphenyl)-glycidic acid methyl ester O 50 mg O OMe O LGCFOR1005.01 4-Methyl-1-(3-methylpyridin-2-yl)-2-phenylpiperazine 10 mg

N N

O LGCFOR1275.01 Methylone Hydrochloride H 10 mg N O x HCl

O CERM-140 Methylone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERM-141 Methylone-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

CERM-083 Methylphenidate HCl (1.0 mg/ml) 1 mL in Methanol

HCl H N CH C O CH3 O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERM-127 Methylphenidate-D9 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

NMIAD525 N-Methyl-1-phenylethylamine HCl 50 mg NH .HCl

H LGCFOR1275.54 N-Methyl-2-phenylethylamine Hydrochloride (N-Methyl-PEA HCl) N 10 mg x HCl

LGCFOR1280.01 1-Methyl-4-(phenylmethyl)piperazine HCl N 10 mg x HCl N LGCFOR1005.07 1-Methyl-3-phenylpiperazine 10 mg

N HN LGCFOR1275.62 4'-Methyl-alpha-pyrrolidinobutiophenone Hydrochloride (MPBP HCl) O 10 mg N x HCl

NMIAD964 (±)-4'-Methyl-pyrrolidinopropiophenone Hydrochloride (MPPP) O 20 mg CH3 .HCl N H3C

NMIAD687 (±)-4-Methylthioamphetamine HCl (MTA) CH3 20 mg NH . HCl MeS 2 TRC-M330725 alpha-Methythio fentanyl 1 mg TRC-M330730 3-Methylthio fentanyl 1 mg CERA-074 alpha-Methyltryptamine (0.1 mg/mL) 1 mL in Methanol

OH LGCFOR0027.00 Metoprolol Tartrate H 10 mg O N

O 2 OH O x HO OH O OH CERM-123 Metroprolol tartrate (1.0 mg/ml) 1 mL in Methanol

LGCFOR0147.00 Mianserin HCl N 10 mg N x HCl

CERM-919 Mianserin HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERM-901 Mianserin-D3 (0.1 mg/ml) 1 mL in Methanol N

N CD 3 LGCFOR0147.06 Mianserin N-Oxide O 10 mg N N

CERM-908 Midazolam (1.0 mg/ml) Cl 1 mL in Methanol

CH3 N

N N F

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERM-918 Midazolam-D4 maleate (0.1 mg/ml) (as free Cl 1 mL D base) D

in Methanol D CH3 COOH N

N D N COOH F CERM-145 Milnacipran HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CERM-128 Mirtazepine (1.0 mg/ml) 1 mL in Methanol

LGCFOR0250.00 Moclobemide O O 10 mg N N H Cl CERM-084 Modafinil (1.0 mg/ml) 1 mL in Acetonitrile

CERM-103 Modafinil-D10 (0.1 mg/ml) 1 mL in Acetonitrile

CERM-142 Modafinil acid (1.0 mg/ml) 1 mL in Acetonitrile

LGCFOR0267.00 Molsidomine O 10 mg O O N - N N+ N O NMIAD777 6-Monoacetylmorphine base OH 20 mg

O H N

CH3 AcO NMIAD766 3-Monoacetylmorphine sulfamate AcO 20 mg

H2NO3S O H N CH3 H HO THC-167 Morphinhemisulfat-pentahemihydrat 100 mg

LGCFOR0280.00 Morphine hemisulphate pentahemihydrate [Controlled Substance] N 10 mg

x H2SO4 x 5 H2O

HO O OH 2

LGCFOR0037.00 Morphine HCl trihydrate [Controlled Substance] N 10 mg

x HCl x 3 H2O

HO O OH CERM-030 Morphine (0.1 mg/ml) HO 1 mL in Methanol

N CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERM-005 Morphine (1.0 mg/ml) (morphine anhydrate) HO 1 mL in Methanol O

N CH3

CERM-003 Morphine-D3 (0.1 mg/ml) HO 1 mL in Methanol

N CD3

CERM-006 Morphine-D3 (1.0 mg/ml) HO 1 mL in Methanol

N CD3

CERM-085 Morphine-D6 (0.1 mg/ml) HO 1 mL

in Methanol D D D O

N CD3

CERM-086 Morphine-D6 (1.0 mg/ml) HO 1 mL

in Methanol D D D O

N CD3

NMIAD709 Morphine base monohydrate-D3 OH 1 mg

O H CD N 3

OH NMIAD408 Morphine base monohydrate HO 50 mg

O H

N CH3

CERM-018 Morphine-3beta-D-glucuronide (0.1 mg/ml) O 1 mL in Methanol COOH O O H H N CH 3 OH H HO H HO H OH O CERM-031 Morphine-3beta-D-glucuronide (1.0 mg/ml) HOOC O 1 mL in Methanol

HO OH O OH N CH3

HO O CERM-017 Morphine-3beta-D-glucuronide-D3 (0.1 mg/ml) HOOC O 1 mL in Methanol

HO OH O OH N CD3

HO CERM-096 Morphin-6beta-D-glucuronide (0.1 mg/ml) HO 1 mL in methanol : water (50 : 50) O N CH3

HOOC O O

HO OH OH

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERM-046 Morphine-6-beta-D-glucuronide (1.0 mg/mL) 1 mL water : methanol (80:20)

CERM-120 Morphine-6beta-D-glucurunide-D3 (0.1 mg/mL) HO 1 mL in methanol : water (50 : 50)

O N CD3

HOOC O O

HO OH OH NMIAD700 Morphine N-Oxide HO 10 mg

O N+Me H O - HO

CERM-108 MTBSTFA (with 1% t-BDMCS) CH3 CH3 O 5 x 1 mL

H3C C Si N CCF3

CH3 CH3 CH3

CH3 CH3 + CH3 C Si Cl

CH3 CH3

LGCFOR1001.06 Mycophenolic Acid O OH 10 mg OH O O O

CERM-106 Mycophenolic acid (1.0 mg/ml) 1 mL in Acetonitrile

CERM-137 Mycophenolic acid-D3 (0.1 mg / mL) 1 mL in Acetonitrile

CERM-135 Mycophenolic acid-beta-D-glucuronide (1.0 mg/ml) 1 mL in Acetonitrile

CERN-051 Nalbuphine (1.0 mg/ml) 1 mL in Methanol

LGCFOR0272.00 Naloxone Hydrochloride Dihydrate N 10 mg x HCl HO x 2 H2O

HO O O CERN-004 Naloxone (1.0 mg/mL) HO 1 mL in Methanol O N CH OH 2 O CERN-063 Naloxone-D5 (0.1 mg/ml) 1 mL in Methanol

CERN-038 6 beta-Naltrexol (1.0 mg/ml) HO 1 mL in Methanol O N OH HO

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR0233.00 Naltrexone Hydrochloride N 10 mg

HO x HCl

HO O O CERN-007 Naltrexone (1.0 mg/mL) HO 1 mL in Methanol O N OH O

CERN-047 Naltrexone-D3 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0660.00 Nandrolone OH 10 mg

O LGCFOR1275.06 Naphyrone Hydrochloride (1-Naphthalen-2-yl-2-pyrrolidin- O 10 mg 1-ylpentan-1-one Hydrochloride) N x HCl

CERN-067 Naphyrone HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

LGCFOR1275.35 1-Naphyrone Hydrochloride (1-Naphthalen-1-yl-2-pyrrolidin-1-ylpentan- 10 mg N O 1-one Hydrochloride) x HCl

LGCFOR0152.00 Naproxen 10 mg OH

O O CERN-042 Naproxen (1.0 mg/mL) CH3 1 mL in Methanol OH

O H3CO TRC-N389750 Nelfinavir mesylate 10 mg TRC-N389752 Nelfinavir-D3 1 mg TRC-N389760 Nelfinavir hydroxy-tert-butylamide 1 mg TRC-N391275 Nevirapine 5 mg TRC-N391277 Nevirapine-D5 1 mg LGCFOR0517.00 Nicotine 10 mg N N

CERN-008 S(-)-Nicotine (1.0 mg/ml) H 1 mL

im Methanol N

CH 3 N

CERN-048 Nicotine-D4 (0.1 mg/ml) D 1 mL in Acetonitrile D N

CH 3 DDN

H O LGCFOR0078.00 Nitrazepam [Controlled Substance] N 10 mg

O2N N

CERN-906 Nitrazepam (1.0 mg/ml) O2N 1 mL in Acetonitrile

NH N O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERN-901 Nitrazepam-D5 (0.1 mg/ml) O2N 1 mL in Methanol DD

D NH N DD O LGCFOR0660.01 Norandrostenedione (19-Norandrost-4-ene-3,17-dione) O 10 mg

O CERN-057 Noratropine HCl (1.0 mg/mL) (as free base) 1 mL in Methanol

CERN-022 Norbenzoylecgonine HCl (1.0 mg/ml) H 1 mL HCl N COOH in Methanol H O O C H

CERN-912 Norbuprenorphine (0.1 mg/ml) HO 1 mL in Methanol

O NH

CH3O

HO C CH3

C(CH3)3 CERN-059 Norbuprenorphine (1.0 mg/ml) 1 mL in Methanol

CERN-921 Norbuprenorphine-D3 (1.0 mg/ml) 1 mL in Methanol

CERN-920 Norbuprenorphine-D3 (0.1 mg/ml) HO 1 mL in Methanol

O NH

CD3O

HO CCH3

C(CH3)3

CERN-045 Norbuprenorphine glucuronide (0.1 mg/ml) HOOC O O 1 mL in Methanol HO OH O OH NH

H3C O

HO CH3 C(CH3)3 CERT-006 (±)-11-nor-9-carboxy-delta 9-THC (0.1 mg/ml) COOH 1 mL in Methanol OH

H 3 C

H 3 C O CH 3

CERT-004 (±)-11-nor-9-carboxy-delta 9-THC-D3 (0.1 mg/ml) COOH 1 mL in Methanol OH

H3C

H3C OCD3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERT-008 (±)-11-nor-9-carboxy-delta 9-THC-D3 (1.0 mg/ml) COOH 1 mL in Methanol OH

H3C

H3C OCD3

CERT-007 (±)-11-nor-9-carboxy-delta 9-THC-D9 (0.1 mg/ml) COOH 1 mL in Methanol OH

D 3 C

D 3 C O CD 3 CERT-038 (+)-11-Nor-delta 9-THC-9-carboxylic acid glucuronide 1 mL (not to be used for immunoassay) (0.1 mg/ ml) in Methanol

CERT-018 (-)-11-nor-9-carboxy-delta 9-THC (0.1 mg/ml) COOH 1 mL in Methanol OH

H3C

H3C O CH3

CERT-019 (-)-11-nor-9-carboxy-delta 9-THC (1.0 mg/ml) COOH 1 mL in Methanol OH

H3C

H3C O CH3

NMIAD856 Norcocaine HCl .HCl O 10 mg HN OMe H O Ph

H O CERN-034 Norcocaine-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Acetonitrile

CERN-003 Norcocaine (1.0 mg/ml) H 1 mL in Acetonitrile HCl N COOCH 3 H O

H LGCFOR0004.05 Norcodeine [Controlled Substance] HN 10 mg

O O OH NMIAD698 Norcodeine MeO 5 mg

O NH H HO

CERN-005 Norcodeine (1.0 mg/ml) CH 3 O 1 mL in Methanol

N H

H O LGCFOR0023.02 Nordazepam [Controlled Substance] N 10 mg

Cl N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERN-905 Nordiazepam (1.0 mg/ml) Cl 1 mL in Methanol

NH N O

CERN-903 Nordiazepam-D5 (0.1 mg/ml) Cl 1 mL in Methanol DD

D NH N DD O

CERN-911 Nordiazepam-D5 (1.0 mg/ml) Cl 1 mL in Methanol DD

D NH N DD O LGCFOR0490.03 Nordiphenhydramine Hydrochloride 10 mg

H x HCl N O

NMIAM296 Norephedrine HCl (Phenylpropanolamine) - DRUG PRECURSOR HO 100 mg HCl

NH2 CERN-043 (±)-Norephedrine-D3 HCl (1.0 mg/ml) (as free base) OH 1 mL ((±)-Phenylpropanolamine HCl) CD3 in Methanol NH2 HCl

LGCFOR0608.01 Norfenfluramine Hydrochloride NH2 10 mg

x HCl F F F CERN-031 Norfentanyl oxalate (1.0 mg/ml) (as free base) 1 mL in Methanol COOH O N COOH NH H3C CERN-055 Norfentanyl-D5 oxalate (0.1 mg/ml) (as free base) 1 mL in Methanol

CERN-030 Norfentanyl-D5 oxalate (0.1 mg/ml) (as free base) D 1 mL in Acetonitrile D D

D D COOH O N COOH

NH H3C CERN-923 Norfluoxetine oxalate (1.0 mg/m) (as free base) ONH2 1 mL in Methanol COOH F3C COOH

D CERN-922 Norfluoxetine-D6 oxalate (0.1 mg/m) (as free base) ONH2 1 mL in Methanol D D COOH F3C COOH D D D

CERN-036 (±)-Norketamine HCl (1.0 mg/ml) Cl 1 mL O in Methanol

NH2 HCl

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERN-037 (±)-Norketamine-D4 HCl (0.1 mg/ml) D 1 mL in Methanol Cl D O D

D NH2 HCl

CERL-017 nor-LSD/ nor-iso-LSD O O 5 mg H 5 C 2 H 5 C 2 N C N C H C 5 2 NH H 5 C 2 NH H H H H

N N H H

CERN-017 Normeperidine (0.1 mg/ml) H 1 mL in Methanol N

COCH2CH3 O

CERN-020 Normeperidine-D4 (0.1 mg/ml) H 1 mL in Methanol N

D D D D

COCH2CH3 O

NMIAD701 Normorphine HO 5 mg

O NH H HO CERN-006 Normorphine (1.0 mg/ml) HO 1 mL in Methanol

N H

HO LGCFOR0672.03 Noroxycodone Hydrochloride H 10 mg N

HO x HCl

O O O CERN-011 Noroxycodone HCl (1.0 mg/ml) (as free base) HO 1 mL in Methanol

O OH NH

CERN-032 Noroxycodone-D3 (0.1 mg/ml) CD3O 1 mL in Methanol

O OH NH

CERN-013 Noroxymorphone (0.1 mg/ml) HO 1 mL in Methanol

O OH N H

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERN-012 Noroxymorphone (1.0 mg/mL) HO 1 mL in Methanol / DMSO

O OH NH

N O LGCFOR0059.06 Norpheniramine Maleate H 10 mg N OH x OH

NMIAM937 Norphenylephrine HCl N 50 mg H N x

CERN-913 (±)-Norpropoxyphene maleate (1.0 mg/ml) 1 mL in Methanol

CH3 CH2 C O C CH CH2 NH CH3

O CH2 CH3

HH CC HOOC COOH

CERN-904 (±)-Norpropoxyphene-D5 maleate (0.1 mg/ml) D 1 mL in Methanol D D

D D

CH3 CH2 C OCHCHC 2 NH CH3

O CH2 CH3 HH CC HOOC COOH

CERN-919 (±)-Norpropoxyphene-D5 maleate (1.0 mg/ml) D 1 mL in Methanol D D

D D

CH3 CH2 C OCHCHC 2 NH CH3

O CH2 CH3 HH CC HOOC COOH

NMIAM297 (+)-Norpseudoephedrine HCl (Cathine) OH 50 mg NH2 HCl CERN-046 Norpseudoephedrine HCl (0.1 mg/ml) as free base 1 mL in Methanol

CERN-049 Norsertraline HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

H O LGCFOR0091.03 Nortetrazepam N 10 mg

Cl N

CERN-062 Nortilidine-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

CERN-061 Nortilidine HCl (1.0 mg/mL) (as free base) 1 mL in Methanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0079.00 Nortriptyline Hydrochloride 10 mg

N H x HCl

CERN-907 Nortriptyline (1.0 mg/ml) 1 mL in Methanol

CH CH 2 CH 2 NH CH 3 CERN-902 Nortriptyline-D3 HCl (0.1 mg/ml) 1 mL in Methanol

CH CH 2 CH 2 NH CD 3 HCl NMIAD831 Noscapine (Narcotine) base O 50 mg N O Me OMe O

O OMe MeO LGCFOR0528.08 N-Phenyl-N-(piperidin-4-yl)propanamide O NH 10 mg

TRC-O415000 Ohmefentanyl 1 mg TRC-0415002 Ohmefentanyl-D3 1 mg CERO-024 Olanzapine (1.0 mg/ml) 1 mL in Acetonitrile

EJ-O139-0121 Olanzapine D3 10 mg CERO-035 Olanzapine-D8 (0.1 mg/ml) 1 mL iin Acetonitrile

CERO-021 Omeprazole HCl (1.0 mg/ml) H3C OCH3 1 mL in Methanol H N CH3 S N N O H3CO CERO-032 Orlistat (1.0 mg/mL) 1 mL in Acetonitrile

TRC-O695300 Orphenadrine citrate salt 5 g TRC-O695302 Orphenadrine citrate salt-D3 1 mg NMIAD912 Ortetamine HCl (1-(2-methylphenyl)-2-propylamine HCl) 10 mg CH3

NH2 .HCl H O LGCFOR0080.00 Oxazepam N 10 mg OH Cl N

CERO-902 Oxazepam (1.0 mg/ml) Cl 1 mL in Methanol

N O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERO-901 Oxazepam-D5 (0.1 mg/ml) Cl 1 mL in Methanol D D

D NH

N DD O OH

CERO-904 Oxazepam-D5 (1.0 mg/ml) Cl 1 mL in Acetonitrile D D

D NH N D D O OH CERO-023 Oxazepam glucuronide (0.1 mg/ml) Cl 1 mL in Methanol / Water (1 : 1)

NH N O HOOC O O

HO OH OH

LGCFOR0076.17 Oxcarbazepine O 10 mg

N NH2

CERO-025 Oxcarbazapine (1.0 mg/ml) 1 mL in Acetonitrile

OH NMIAD892 Oxilofrine HCl H HCl 5 mg N

O CERO-013 2-Oxo-3-hydroxy-LSD (0.1 mg/ml) H 5 C 2 1 mL in Acetonitrile N C CH3 H 5 C 2 N H H

N H

LGCFOR0672.00 Oxycodone HCl N 10 mg

HO x HCl

O O O

CERO-002 Oxycodone (1.0 mg/ml) CH 3 O 1 mL in Methanol

O OH

N CH 3

CERO-005 Oxycodone-D3 (0.1 mg/ml) CD3O 1 mL in Methanol

O OH

N CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CERO-006 Oxycodone-D3 (1.0 mg/ml) CD3O 1 mL in Methanol

O OH

N CH3

CERO-007 Oxycodone-D6 (0.1 mg/ml) CD3O 1 mL in Methanol

O OH N CD3

CERO-008 Oxycodone-D6 (1.0 mg/ml) CD3O 1 mL in Methanol

O OH N CD3

CERO-004 Oxymorphone (1.0 mg/ml) HO 1 mL in Methanol

O OH

N CH 3

CERO-003 Oxymorphone-D3 (0.1 mg/ml) HO 1 mL in Methanol

O OH N CD3

CERO-019 Oxymorphone-D3 (1.0 mg/mL) HO 1 mL in Methanol

O OH N CD3

O NMIAD791 Noscapine (Narcotine) HCl O HCl 100 mg N O Me MeO O

O OMe MeO LGCFOR0095.00 Omeprazole 10 mg O NH O N S O N

LGCFOR1275.16 ortho-Chlorophenylpiperazine Hydrochloride (oCPP HCl) NH 10 mg N x HCl

Cl NMIAD734 Oripavine HO 50 mg

O N

CH3 CH3O LGCFOR0957.00 Oxomemazine 10 mg N

S O O OH LGCFOR0129.00 Oxprenolol Hydrochloride H 10 mg O N x HCl

146 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0099.01 Pantoprazole 10 mg O NNa O F O F N S O N NMIAD750 Papaverine HCl OMe 100 mg OMe

MeO N HCl

MeO NMIAD743 Papaveraldine OMe 20 mg O OMe MeO N

MeO LGCFOR0042.00 Paracetamol 10 mg O NH O F O F N S O N H CERA-064 Acetaminophen (1.0 mg/ml) (Paracetamol) N CH3 1 mL in Methanol O HO

CERP-909 Acetaminophen-D4 (0.1 mg/ml) (Paracetamol) D 1 mL

in Methanol D NH CCH3 O HO D D

CERP-917 Acetaminophen-D4 (1.0 mg/ml) (Paracetamol) D H 1 mL in Methanol D N CH3

O HO D D

H CERP-916 Paroxetine (1.0 mg/mL) N 1 mL in Methanol O O

HH F • HOOC COOH

D H D CERP-915 Paroxetine-D6 maleate (0.1 mg/mL) (as free base) N 1 mL in Methanol D D O O

D D O

F • HOOC COOH CERP-010 Pentobarbital (1.0 mg/ml) H 1 mL in Methanol O N O

CH 3 CH 2 N H CH 3 CH 2 CH 2 CH O CH 3

CERP-009 Pentobarbital-D5 (0.1 mg/ml) H 1 mL in Methanol O N O

CD 3 CD 2 N H CH 3 CH 2 CH 2 CH O CH 3

CERP-013 Pentobarbital-D5 (1.0 mg/ml) H 1 mL in Methanol O N O

CD 3 CD 2 N H CH 3 CH 2 CH 2 CH O CH 3

O LGCFOR1275.57 Pentylone Hydrochloride H 10 mg O N x HCl O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

LGCFOR0815.00 Perazine dimaleate N O 10 mg N HO x 2 N HO

O S

LGCFOR0157.01 Perazine Sulphoxide N 10 mg N

S O LGCFOR0826.00 Perphenazine 10 mg

N N S N OH

Cl LGCFOR0826.01 Perphenazine Sulphoxide 10 mg

N N S N O OH

Cl H LGCFOR0551.00 Phenacetin N 10 mg

O O CERP-061 Phenacetin (1.0 mg/mL) O 1 mL in Acetonitrile H3C HN O

CH3

H O LGCFOR0828.00 Phenazepam N 10 mg

Br N

CERP-080 Phenazepam (1.0 mg/ml) 1 mL in Acetonitrile

NMIAD748 Phencyclidine HCl 50 mg N .HCl

CERP-007 Phencyclidine (1.0 mg/ml) (PCP) 1 mL in Methanol N

CERP-003 Phencyclidine-D5 (0.1 mg/ml) (PCP) D 1 mL in Methanol D D

N D D

CERP-006 Phencyclidine-D5 (1.0 mg/ml) (PCP) D 1 mL in Methanol D D

N D

NH2 LGCFOR1275.47 2-Phenylethylamine Hydrochloride x HCl 10 mg (Phenethylamine Hydrochloride, PEA HCl) CERP-045 Pheniramine (1.0 mg/ml) 1 mL in Methanol

CH3

HC CH2CH2N

CH3 N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERP-062 Pheniramine-D6 maleate salt (0.1 mg/ml) (as free base) 1 mL in Methanol

CERP-008 Phenobarbital (1.0 mg/ml) H 1 mL in Methanol O N O

CH 3 CH 2 N H O

CERP-018 Phenobarbital-D5 (0.1 mg/ml) H 1 mL in Methanol O N O CH 3 CH 2 (deuterium label on ring) D N H D O D D D

CERP-019 Phenobarbital-D5 (1.0 mg/ml) H 1 mL in Methanol O N O (deuterium label on ring) CH3 CH2 D N H D O D D D

CERP-004 Phenobarbital-D5 (0.1 mg/ml) H 1 mL in Methanol O N O

(deuterium label on side chain) CD 3 CD 2 N H O

CERP-017 Phenobarbital-D5 (1.0 mg/ml) H 1 mL in Methanol O N O

(deuterium label on side chain) CD3 CD2 N H O

Me NMIAD781 Phentermine HCl Me 100 mg HCl NH2

CERP-023 Phentermine (1.0 mg/ml) CH3 1 mL

in Methanol CH2 C NH2

CH3

NMIAD917 Phenylacetic acid - DRUG PRECURSOR OH 50 mg

LGCFOR0548.00 Phenylbutazone O 10 mg

N N

CERP-021 Phenylbutazone (1.0 mg/ml) 1 mL in Acetonitril

O N N

CH3(CH2)3 O CERP-078 R(-)-Phenylephrine HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

NMIAD869 1-Phenyl-2-nitropropene H 100 mg NO2

CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0528.04 N-Phenyl-1-(2-phenylethyl)piperidin-4-amine 10 mg

LGCFOR0528.08 N-Phenyl-N-(piperidin-4-yl)propanamide O NH 10 mg

LGCFOR0656.00 Phenylpropanolamine Hydrochloride (D,L-Norephedrine OH 10 mg NH Hydrochloride) 2 x HCl

and enantiomer CERP-038 (±)-Phenylpropanolamine HCl (Norephedrine HCl) OH 1 mL

(1.0 mg/ml) (as free base) DRUG PRECURSOR CH3 in Methanol HCl NH 2

LGCFOR0770.00 Phenyltoloxamine Citrate O 10 mg OH N O OH x O

OH OH O LGCFOR0630.00 Phenytoin 10 mg H N O

CERP-063 Phenytoin (1.0 mg/ml) 1 mL in Methanol

NMIAD539 Pholcodine O 20 mg N O O H

NCH3

OH LGCFOR0539.07 Piperazine Hexahydrate NH 10 mg x 6 H2O HN

NMIAD870 Piperonal - DRUG PRECURSOR O 100 mg

O H O

NMIAD881 Piperonyl alcohol O OH 50 mg

O O LGCFOR1275.46 1-Piperonylpiperazine N 10 mg NH O

NMIAD756 (±)-4-Methoxyamphetamine HCl (PMA) CH3 50 mg

NH2 .HCl OH3C

CERP-050 PMA (p-Methoxyamphetamine) HCl (1.0 mg/mL) CH3 1 mL in Methanol NH2 H3CO HCl

NMIAD908 PMMA ((±)-4-Methoxymethamphetamine HCl) CH3 10 mg

MeO NHMe.HCl

CH CERP-051 PMMA (p-Methoxymethamphetamine) HCl (1.0 mg/mL) 3 1 mL

in Methanol NH CH3 H3CO HCl LGCFOR0651.00 Prasterone (DHEA, Dehydroepiandrosterone) O 10 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERP-906 Prazepam (1.0 mg/ml) Cl 1 mL in Methanol

N CH2 N O

CERP-905 Prazepam-D5 (0.1 mg/ml) Cl 1 mL

in Methanol D D

D N CH 2 N O DD CERP-072 Pregabalin-D6 (0.1 mg/ml) 1 mL in Methanol

CERP-075 Primidone (1.0 mg/ml) 1 mL in Methanol

LGCFOR0596.00 Procaine Hydrochloride O 10 mg N O x HCl

H2N TRC-P755800 Prochlorperazine 10 mg

LGCFOR0290.00 Promazine HCl N 10 mg

N x HCl

S LGCFOR0290.01 Promazine Sulphoxide 10 mg N

S O LGCFOR0412.00 Promethazine HCl 10 mg N N x HCl S

CERP-044 Promethazine HCl CH3 25 mg CH 2 CH N(CH3)2 HCl N

CH CERP-910 Promethazine-D3 HCl 3 CH3 5 mg CH2 CH N HCl CD N 3

S LGCFOR0412.04 Promethazine Sulphoxide 10 mg N N S O

LGCFOR0222.00 Progesterone O 10 mg

LGCFOR0043.00 Propranolol Hydrochloride OH 10 mg H O N x HCl

CERP-055 Propanolol HCl (1.0 mg/ml) (as free base) OH 1 mL in Acetonitril H O N CH3

HCl CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERP-076 Propofol (1.0 mg/ml) 1 mL in Methanol

CERP-077 Propofol-D17 (0.1 mg/ml) 1 mL in Methanol

CERP-011 D-Propoxyphene (1.0 mg/ml) 1 mL in Methanol

CH 3

CH 3 CH 2 COC CH CH 2 N CH O CH 2 CH 3 3

CERP-901 (±)-Propoxyphene-D5 (0.1 mg/ml) D 1 mL in Methanol D D

D D CH 3 CH CH COC 3 2 CH CH 2 N O CH CH 2 CH 3 3

CERP-904 (±)-Propoxyphene-D5 (1.0 mg/ml) D 1 mL in Methanol D D

D D CH3 CH3 CH2 C O C CH CH2 N CH3 O CH2 CH3

CERP-913 (±)-Propoxyphene-D11 (0.1 mg/ml) D 1 mL in Methanol D D

D D CD3 CH3 CH2 C O C CH CH2 N CD3 O CH2 CH3

CERP-914 (±)-Propoxyphene-D11 (1.0 mg/ml) D 1 mL in Methanol D D

D D CD3 CH3 CH2 C O C CH CH2 N CD3 O CH2 CH3

H NMIAM394 Propylhexedrine N 50 mg CH3

CH3

H NMIAD495 (±)-N-Propyl-3,4-methylenedioxyamphetamine HCl O N 20 mg

O NMIAD859 N-Propylnorlaudanosine MeO 10 mg

MeO O MeO N

MeO CERP-903 Protriptyline HCl (1.0 mg/ml) (as free base) 1 mL in Methanol

CH2 CH2 CH2 NH CH3 HCl CERP-902 Protriptyline-D3 (0.1 mg/ml) 1 mL in Methanol

CH2 CH2 CH2 NH CD3

NMIAD397 (-)-Pseudoephedrine base - DRUG PRECURSOR OH 100 mg CH3

HN CH3

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR2115.00 (+)-Pseudoephedrine HCl (DRUG PRECURSOR) OH 10 mg NH x HCl

NMIAD775 (+)-Pseudoephedrine HCl - DRUG PRECURSOR OH 100 mg

CH3

MeHN .HCl

CERP-036 (-)-Pseudoephedrine (1.0 mg/ml) HO H 1 mL H in Methanol - DRUG PRECURSOR C CH C 3

NHCH3

CERP-035 (+)-Pseudoephedrine (1.0 mg/ml) H 1 mL H in Methanol - DRUG PRECURSOR C NHCH C 3 OH CH3

OH CERP-056 Pseudoephedrine-D3 HCl (0.1 mg/ml) (as free base) H HCl 1 mL in Methanol N CD3

CH3 ALL-013641 Psilocybin (0.1 mg/mL) (base) 1 mL in Methanol

CERP-048 Psilocin OH 5 mg CH3 CH2CH2N CH3

N H NMIAD726 Psilocin 10 mg

THC-1137A Psilocin (1 mg/ mL) 1 mL in Acetonitrile ALL-013661 Psilocin (0.1 mg/ml) (base) 1 mL in Methanol

CERP-049 Psilocin-D10 OH 5 mg CD3 CD2CD2N CD3

TRC-Q510000 Quetiapine hemifumarate 1 g CERQ-001 Quetiapine fumarate, 1.0 mg/mL (as free base) 1 mL in Methanol

TRC-Q694000 Quinine 1 g EJ-Q646-0311 Quinine-D3 unit TRC-Q694010 Quinine-1 oxide 2.5 mg TRC-Q694012 Quinine 1-oxide-D3 1 mg TRC-Q694015 Quinine N-oxide 2.5 mg H H LGCFOR0086.00 Ranitidine Hydrochloride O N N 10 mg N S x HCl

NO2 HCl CERR-002 Ranitidine HCl H H 250 mg O H3C N N N S CH3

CH3 NO2 TRC-R142000 Reboxetine mesylate 10 mg TRC-R142002 Reboxetine mesylate-D5 1 mg THC-1375M RCS-4 (1 mg/ml) in Methanol 1 mL THC-1374M RCS-8 (1 mg/ml) in Methanol 1 mL

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0542.00 Ribavirin O 10 mg

H2N N HO N N O

OH OH LGCFOR0491.00 Risperidone N 10 mg N F N O

NO CERR-006 Risperidone (1.0 mg/ml) 1 mL in Methanol

TRC-R525002 Risperidone-D4 2.5 mg CERR-013 Risperidone-D4 (0.1 mg/ml) 1 mL in Methanol

LGCFOR1031.04 Ritalinic Acid O OH 10 mg H N

CERR-014 (±)-threo-Ritalinic acid-D10 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

TRC-R535000 Ritonavir 10 mg TRC-R535002 Ritonavir-D6 0.5 mg TRC-R535003 Ritonavir-13C3 0.5 mg

OH LGCFOR0381.00 Salbutamol Sulphate H 10 mg N

x H2SO4 HO

OH 2 LGCFOR0045.00 Salicylic Acid O 10 mg OH

OH CERS-019 Salicylic acid (1.0 mg/mL) 1 mL in Acetonitrile

TRC-S088127 Salicylic acid-D4 5 mg TRC-S135000 Saquinavir mesylate 10 mg TRC-S135002 Saquinavir-D9 1 mg CERS-002 Secobarbital (1.0 mg/ml) H 1 mL in Methanol O N O

CH 2 CH CH 2 N H CH 3 CH 2 CH 2 CH O CH 3

CERS-001 Secobarbital-D5 (0.1 mg/ml) H 1 mL in Methanol O N O

CD 2 CD CD 2 N H CH 3 CH 2 CH 2 CH O CH 3

NMIAD822 Selegiline HCl CH3 50 mg N .HCl H3C

CERS-004 Selegiline-D8 (0.1 mg/ml) D CD3 CH2CCH 1 mL in Methanol CCN H D CD3

CERS-003 R(-)-Selegiline ((-)-Deprenyl) (1.0 mg/ml) CH3 1 mL CH in Methanol N C H3C

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0317.00 Sertraline HN 10 mg

Cl Cl LGCFOR0317.01 Sertraline HCl HN 10 mg

x HCl

Cl Cl CERS-021 Sertraline HCl (1.0 mg/mL) (as free base) HN 1 mL

in Methanol x HCl

Cl Cl CERS-026 Sertraline-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

LGCFOR0254.09 Sildenafil O 10 mg HN N O O N S N N N O LGCFOR0254.00 Sildenafil citrate O O 10 mg N HO O O O HN N x S HO N N HO OH N O O CERS-010 Sildenafil (1.0 mg/ml) 1 mL in Methanol

EJ-191-0631 Sildenafil-D8 unit LGCFOR0254.04 Sildenafil N-Oxide O 10 mg HN N O O N S N N O N O CERS-015 Sirolimus (Rapamycin) (1.0 mg/mL) 1 mL in Acetonitrile

TRC-S685250 Stavudine 10 mg TRC-S685252 Stavudine-D3 1 mg CERS-008 Sufentanil citrate (0.1 mg/ml) (as free base) O OH O 1 mL O CH in Methanol HO OH 3 HOO N

N O CH3 S CERS-018 Sufentanil-D5 (0.1 mg/ml) 1 mL in Methanol

LGCFOR0051.00 Sulpiride O O 10 mg O S N N H2N H O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERT-049 Tacrolimus (1.0 mg/mL) 1 mL in Acetonitrile

CERT-072 Tadalafil (1.0 mg/ml) 1 mL in Acetonitrile

CERT-058 Tapentadol HCl (1.0 mg/mL (as free base) 1 mL in Methanol

CERT-060 Tapentadol-beta-D-glucuronide (0.1 mg/ml) 1 mL 1:1 Acetonitrile:Water

CERT-067 Tapentadol-D3-beta-D-glucuronide (0.1 mg/ml) 1 mL in 1:1 Acetonitrile:Water

CERT-061 Tapentadol-O-sulfate (0.1 mg/ml) (as free acid) 1 mL in Methanol

CERT-907 Temazepam (1.0 mg/ml) Cl 1 mL in Methanol

N CH 3 N O

CERT-902 Temazepam-D5 (0.1 mg/ml) Cl 1 mL

in Methanol DD

D N CH 3 N DD O OH

CERT-912 Temazepam-D5 (1.0 mg/ml) Cl 1 mL

in Methanol DD

D N CH 3 N DD O OH CERT-050 Temazepam glucuronide lithium salt (0.1 mg/ml) (as free acid) 1 mL in Methanol TRC-T018500 Tenofovir 5 mg TRC-T018502 Tenofovir-D6 1 mg TRC-T018510 Tenofovir diphosphate 1 mg LGCFOR0323.00 Testosterone OH 10 mg

O LGCFOR0493.00 Testosterone Benzoate O 10 mg O

O LGCFOR0863.00 Testosterone Isocaproate O 10 mg O

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Drugs and metabolites of forensic and clinical interest

Code Product Unit LGCFOR0897.00 Testosterone Propionate O 10 mg O

O N S LGCFOR0703.00 Tetramisole Hydrochloride x HCl 10 mg N

O LGCFOR0091.00 Tetrazepam N 10 mg

Cl N

TRC-T444900 Tipranavir 1 mg TRC-T444902 Tipranavir-D4 1 mg CERT-033 Exo-THC (1.0 mg/ml) CH2 1 mL

(delta 9(11)-Tetrahydrocannabinol) OH in Methanol

H3C O CH3 H3C

CERT-032 (-)-delta 8-THC (1.0 mg/ml) CH3 1 mL

in Methanol OH

H3C O CH3 H3C THC-004 (-)-delta 9 THC (Dronabinol) (0.1mg / mL) 1 mL in Methanol

CERT-005 (-)-delta 9-THC (Dronabinol) (1.0 mg/ml) CH 3 1 mL

in Methanol OH

H 3 C

H 3 C O CH 3

CERT-003 (-)-delta 9-THC-D3 (0.1 mg/ml) CH 3 1 mL

(Dronabinol) OH in Methanol

H 3 C

H 3 C O CD 3 THC-1298-5 THCA-A 5 mg (1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene-2-carboxylic acid)

THC-1298M THCA-A (Tetrahydrocannabinolic acid A) (1.0 mg / ml) in Methanol 1 mL NMIAD731B Thebaine free base MeO 20 mg

O N MeO NMIAD715 Thebaol MeO 5 mg

MeO LGCFOR0577.00 Theobromine O 10 mg N HN

O N N

CERT-013 Theobromine (0.1 mg/ml) O CH 3 1 mL in Methanol H N N N O N

CH 3 LGCFOR0176.00 Theophylline O 10 mg H N N

O N N

TRC-T345600 Thienyl fentanyl HCl 1 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit TRC-T345602 Thienyl fentanyl-D3 HCl 1 mg H LGCFOR1275.59 1-(Thiophen-2-yl)-2-methylaminopropane Hydrochloride S N 10 mg (Methiopropamine Hydrochloride, MPA HCl) x HCl CERT-068 Tilidine (1.0 mg/ml) 1 mL in Methanol

CERT-905 Thioridazine (1.0 mg/ml) S 1 mL in Methanol H 3 C S N

CH 2 CH 2 N

H 3 C

LGCFOR0134.05 Tilidine N 10 mg

O O and enantiomer LGCFOR0134.00 Tilidine HCl hemihydrate 10 mg N

x HCl x 1/2 H2O

O O and enantiomer

CERT-036 Tolbutamide (1.0 mg/mL) O O O 1 mL in Acetonitrile S N N CH3 H H

H3C CERT-039 Topiramate (1.0 mg/ml) 1 mL in Methanol

CERT-041 Topiramate-D12 (0.1 mg/mL) 1 mL in Methanol

CERT-062 Tox screen test kit (test mix-9 and internal standard mix-3) 1.2 mL containing the following components in Methanol: Chlorpromazine-D3 Maleate Haloperidol-D4 Prazepam-D5 Amiodarone HCl (±)-Amphetamine Codeine Caffeine Diazepam Doxepin HCl Furosemide Haloperidol Morphine in Methanol

LGCFOR0007.00 Tramadol HCl O 10 mg OH x HCl N

and enantiomer

* CERT-029 Tramadol-13C, D3 HCl (0.1 mg/ml) (as free base) OCD3 1 mL in Methanol

N(CH3)2 HCl

CERT-020 Tramadol-13C, D3 HCl (1.0 mg/mL) (as free base) 1 mL in Methanol

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

CH2N(CH3)2 CERT-027 cis-Tramadol HCl (1.0 mg/ml) H 1 mL in Methanol HCl HO

CH3O

LGCFOR0007.11 Tramadol N-Oxide O 10 mg OH

N O

and enantiomer LGCFOR0421.00 Trazodone HCl 10 mg N N Cl N x HCl N N

O CERT-030 Trazodone HCl (1.0 mg/ml) (as free base) O 1 mL NN in Methanol N N N

HCl

Cl NMIAD863 Triacetylnormorphine AcO 5 mg

O H N Ac

AcO

NMIAD894 Triacetylnormorphine-D9 D3COCO 5 mg

NCOCD3 H D3COCO LGCFOR0306.00 Triamcinolone Hexacetonide O 10 mg O O

HO O O

F O

H N N NNH CERT-014 Triamterene 2 2 100 mg

N N

NH2

CERT-910 Triazolam (1.0 mg/ml ) Cl 1 mL in Methanol

CH 3 N N N Cl N

CERT-908 Triazolam-D4 (0.1mg/ml) Cl 1 mL

in Methanol D D

CH 3 D N N N D Cl N

NMIAD906 m-Trifluoromethylphenylpiperazine HCl F3C 50 mg

N NH

HCl CERT-045 Trifluoromethylphenylpiperazine (TFMPP) HCl (as free base) (1.0 mg/ml) 1 mL in Methanol CERT-920 Trifluoromethylphenylpiperazine-D4 (TFMPP) HCl (0.1 mg/ml) 1 mL in Methanol

NMIAM605 Trimeperidine HCl N .HCl 20 mg

O LGCFOR0958.00 Trimeprazine Tartrate 10 mg N OH O x HO N OH O OH S 2

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Drugs and metabolites of forensic and clinical interest

Code Product Unit

NMIAD778 (±)-3,4,5-Trimethoxyamphetamine HCl (TMA) MeO CH3 20 mg

NH2 .HCl MeO OMe

H3C NMIAD864 trans-3,4,5-Trimethoxycinnamoyl cocaine HCl (in progress) .HCl unit N COOCH3 OMe H OMe

O OMe H O

NMIAD855 3,4,5-Trimethoxycocaine HCl CH3 20 mg . HCl OMe N COOCH3 H OMe

O OMe H O

NMIAD858 3,4,5-Trimethoxytropacocaine HCl Me HCl 10 mg N OMe OMe O OMe H O CERT-904 Trimipramine (1.0 mg/ml) 1 mL in Methanol N CH 3 CH 2 CH CH 2 N CH 3 CH 3 CERT-903 Trimipramine-D3 (0.1 mg/ml) 1 mL in Methanol N CD 3 CH 2 CH CH 2 N CH 3 CH 3

LGCFOR0240.00 Trimipramine maleate O 10 mg

OH N N x OH

NMIAD846 Tropacocaine HCl Me 20 mg N

O Ph

H O LGCFOR0601.03 Tropic Acid O 10 mg

OH CERV-006 Valproic acid (0.1 mg/ml) 1 mL in Methanol LGCFOR0393.00 Venlafaxine HCl 10 mg OH

N x HCl

O CERV-004 Venlafaxine HCl (1.0 mg/ml) 1 mL in Methanol

CERV-009 Venlafaxine-D6 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

LGCFOR0022.00 Verapamil Hydrochloride O 10 mg O x HCl O

N CERV-002 Verapamil HCl (1.0 mg/ml) (as free base) N H3C 1 mL CH3 CH3 in Methanol H3CO N OCH3

HCl H3CO OCH3 THC-1274-M Pravadoline (WIN 48,098) (1 mg/ml) in Methanol 1 mL THC-1276-10 WIN 55,212-2 10 mg THC-1276-M WIN 55,212-2 (1 mg/ml) in Methanol 1 mL

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERW-003 Warfarin (1.0 mg/ml) 1 mL

in Acetonitril O O

H3C O

TRC-Z140000 Zalcitabine 10 mg TRC-Z145000 Zaleplon 100 mg TRC-Z145002 Zaleplon-D5 1 mg CERZ-002 Ziprasidone (1.0 mg/ml) 1 mL in 1,2-Dimethoxyethane

CERZ-001 Zolpidem-D6 (0.1 mg/ml) CH3 1 mL in Methanol N

H3C O CD N 3

D3C CERZ-901 Zolpidem L-(+)-hemitartrate (1 mg/ml) N 1 mL CH3 (as free base) N H3C in Methanol COOH O H OH 1/2 N HO H CH3 H3C COOH O LGCFOR0149.00 Zopiclone Cl 10 mg N O N N N N

O N CERZ-003 Zopiclone (1.0 mg/mL) 1 mL in Methanol

LGCFOR0149.01 Zopiclone Oxide O 10 mg Cl N O O N N N N

O N

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Drugs and metabolites of forensic and clinical interest

Code Product Unit Explosives CERB-002 1,2,4-Butanetriol trinitrate 100 μg/mL in Acetonitrile 1 mL CERB-003 1,2,4-Butanetriol-1,4-dinitrate 100 μg/mL in Acetonitrile 1 mL CERD-002 1,2-Dinitroglycerin 100 μg/mL in Acetonitrile 1 mL CERD-003 1,3-Dinitroglycerin 100 μg/mL in Acetonitrile 1 mL CERERD-148S Dinitroethylene glycol 1000 μg/mL in Acetonitrile 1.2 mL CERD-004 Dinitroethylene glycol (EGDN) 100 μg/mL in Acetonitrile 1 mL CERD-010 1,2-Dinitroglycerin 1000 μg/mL in Acetonitrile 1 mL CERD-011 1,3-Dinitroglycerin 1000 μg/mL in Acetonitrile 1 mL CERERA-017 2-Amino-4,6-dinitrotoluene (3,5-Dinitro-2-methylaniline) 100 mg CERERA-018 4-Amino-2,6-dinitrotoluene (3,5-Dinitro-4-methylaniline) 100 mg CERERA-022S 2-Amino-4,6-dinitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERA-023S 4-Amino-2,6-dinitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERD-032S 1,3-Dinitrobenzene 1000 μg/mL in Acetonitrile 1.2 mL CERERD-033S 2,4-Dinitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERD-152S 2,4-Dinitrotoluene 10 mg/mL in Acetonitrile 5 mL CERERD-034S 2,6-Dinitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERD-109S 3,4-Dinitrotoluene 1000 μg/mL in Methanol 1.2 mL CERERD-079 2,2'-Dinitrodiphenylamine 250 mg CERERD-138 2,4-Dinitrodiphenylamine 250 mg CERERD-080 2,4'-Dinitrodiphenylamine 250 mg CERERD-081 4,4'-Dinitrodiphenylamine 250 mg CERERD-115S Diphenylamine 5000 μg/mL in Methanol 1.2 mL CERERE-032S Ethyl centralite 500 μg/mL in Methanol 1.2 mL CERERR-001S Hexogen (RDX) 1000 μg/mL in Acetonitrile 1.2 mL CERERN-004S Nitrobenzene 1000 μg/mL in Acetonitrile 1.2 mL CERERN-005S 2-Nitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERN-007S 4-Nitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERT-021S Tetryl 1000 μg/mL in Acetonitrile 1.2 mL CERERT-022S 2,4,6-Trinitrotoluene 1000 μg/mL in Acetonitrile 1.2 mL CERERT-023S 1,3,5-Trinitrobenzene 1000 μg/mL in Acetonitrile 1.2 mL CERM-001 1-Mononitroglycerin 100 μg/mL in Acetonitrile 1 mL CERM-002 2-Mononitroglycerin 100 μg/mL in Acetonitrile 1 mL CERM-077 1-Mononitroglycerin 1000 μg/mL in Acetonitrile 1 mL CERM-078 2-Mononitroglycerin 1000 μg/mL in Acetonitrile 1 mL CERERH-004S Octogen (HMX) 1000 μg/mL in Acetonitrile 1.2 mL CERP-037 Nitropenta 1000 μg/mL in Acetonitrile 1 mL CERERG-006 Single based gun propellant surveillance standard unit (nine components in Acetonitrile) CERT-002 Trinitroglycerin 1000 μg/mL in Acetonitrile 1 mL CERT-021 Trinitroglycerin 1% w/w in Propylene glycol 1 mL CERT-022 Trinitroglycerin 1% w/w in Propylene glycol 5 x 0.25 mL CERERE-011 Method 8330 Calibration Standard Solution A 1.2 mL 100 μg/mL of each analyte in Acetonitrile 2-Amino-4,6-dinitrotoluene Nitrobenzene 1,3-Dinitrobenzene Octogen (HMX) 2,4-Dinitrotoluene 1,3,5-Trinitrobenzene Hexogen (RDX) 2,4,6-Trinitrotoluene (TNT)

CERERE-012 Method 8330 Calibration Standard Solution B 1.2 mL 100 μg/mL of each analyte in Acetonitrile 4-Amino-2,6-dinitrotoluene 3-Nitrotoluene 2,6-Dinitrotoluene 4-Nitrotoluene 2-Nitrotoluene Tetryl

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CERERE-021 Method 8330 Stock Solution 1.2 mL 200 μg/mL of each analyte in Acetonitrile 2-Amino-4,6-dinitrotoluene 2-Nitrotoluene 4-Amino-2,6-dinitrotoluene 3-Nitrotoluene 1,3-Dinitrobenzene 4-Nitrotoluene 2,4-Dinitrotoluene Octogen (HMX) 2,6-Dinitrotoluene Tetryl Hexogen (RDX) 1,3,5-Trinitrobenzene Nitrobenzene 2,4,6-Trinitrotoluene (TNT)

CERERE-042 Method 529 Explosives Stock Standard 1.2 mL 2000 μg/mL of each analyte in Ethyl acetate 2-Amino-4,6-dinitrotoluene 2-Nitrotoluene 4-Amino-2,6-dinitrotoluene 3-Nitrotoluene 3,5-Dinitroaniline 4-Nitrotoluene 1,3-Dinitrobenzene 1,3,5-Trinitrobenzene 2,4-Dinitrotoluene 2,4,6-Trinitrotoluene (TNT) 2,6-Dinitrotoluene RDX Nitrobenzene Tetryl

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Drugs and metabolites of forensic and clinical interest

Just send an e-mail to [email protected]

164 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Phytochemical reference standards for forensic scientists

THE SECRET BOX

PRODUCT Mitragynine Structure

O PART NUMBER 00013890 STANDARD TYPE Primary (P) H LOT NUMBER 00013890-1741 N N ANALYTICAL CONDITIONS REPORT NUMBER CDXA-RSS-XXXX H INSTRUMENT AGILENT 1100 HPLC UV-VIS (DAD) DETECTOR (YOUNG), CDXA NUMBER CDXA-08-1741 FINNIGAN LCQ-DECA (CURIE) DATE OF SAMPLE 07/30/2008 O O COLUMN Phenomenex Luna C18(2) 150 x 2.00 mm, 5 μm particle size; S/N 412618-4 DATE OF REPORT 09/29/2008 O MOBILE PHASE A - 0.1% Trifluoroacetic acid in Milli-Q water, B - Acetonitrile;

NAME Mitragynine Isocratic 5% B for 5 minutes, then increasing to 95% B over 20 minutes. Hold at 95% B for 5 minutes. OTHER NAME 16,17-Didehydro-9,17-dimethoxy-17,18-seco-20-α-yohimban-16-carboxylic acid methyl ester; Methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b- COLUMN TEMP. 60 °C octahydroindolo[3,2-h]quinolizin-2-yl]-3-methoxyprop-2-enoate FLOW RATE 0.4 mL/minute CHEMICAL FORMULA C H N O 23 30 2 4 INJECTION VOL. 0.5 μL MOLECULAR WEIGHT (MW) 398.50 INJECTION CONC. 0.7 mg/mL in methanol PUBLISHED MELTING POINT 102-106 °C DETECTION 250 ± 40 nm CAS NUMBER [4098-40-2] EINECS NA HPLC CHROMATOGRAM OF MITRAGYNINE (CDXA-08-1741) DAD1 A, Sig=250,80 Ref =600,100 (G3008\G3008_09.D) CHEMICAL FAMILY Alkaloids mAU .9 42 22 FROM NA 15.144 rea: A ANALYTICAL RESULTS 400

TEST METHOD SPECIFICATION RESULT Adjusted Purity NA NA 94.3% 300 HPLC CDXA-CPM-056-00 NA 99.1% NMR 99.1-CD-1.0-000122 Conforms Conforms Mass Spectrum Direct Infusion, ESI (+) Conforms Conforms 200 Isopropyl alcohol – 3.6% Residual Solvent 99.1-CD-2.0-000115 NA Methanol – 0.1% Water 99.1-CDXA-1.0-000094 NA 1.1% 100 Appearance NA NA White Powder

44 8 ADJUSTED PURITY: 94.3% IS BASED ON (100% - 1.1% WATER - 3.7% SOLVENTS) X 99.1% HPLC 7656 957 8 6 : 2.56 1.6 a:a: 14.72970. ee a: 0 re 14.723

STORAGE CONDITIONS 14.792 Ar 15.350 Ar Area 15.878 A STORAGE -20 °C in a dry place.

0 5 10 15 20 25 min EXPIRATION DATE 07/2013 under the above conditions.

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UV SPECTRUM AT RT = 15.1 MINUTES NMR SPECTRUM OF MITRAGYNINE (CDXA-08-1741) IN CHLOROFORM

*DAD1, 15.145 (1201 mAU,Apx) Ref =15.019 & 15.545 of G3008_09.D mAU

1000

800

600

400

200

200 250 300 350 400 450 500 550 nm MASS SPECTRUM OF MITRAGYNINE (CDXA-08-1741)

H0408_12 #1-40 RT: 0.02-1.01 AV: 40 SB: 2 1.01, 1.01 NL: 9.45E6 T: + c ms [ 150.00-2000.00] 399.40

9000000

8500000

8000000

7500000

7000000

6500000

6000000

5500000

5000000

Intensity 4500000

4000000

3500000

3000000

397.50 2500000 400.41

2000000

1500000

1000000

500000 401.41 395.51 176.28 279.42 324.37 339.46 415.32 257.37 441.19 503.56521.07 557.47 614.80679.28 729.24 750.77 797.60 832.62895.16 998.96 0 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000 m/z

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Code Product Unit Phytos CDX-00001339-005 Aconite standards kit contains: 4 x 5 mg Aconitine Bulleyaconitine A Hypaconitin Lappaconitine CDX-00024920-010 7-Xylotaxol 10 mg CDX-00025010-005 Yangonin 5 mg CDX-00025010-010 Yangonin 10 mg CDX-00025509-010 Yohimbine HCl 10 mg CDX-00025509-025 Yohimbine HCl 25 mg CDX-00025510-025 Yohimbine HCl 25 mg CDX-00025512-010 alpha-Yohimbine HCl (Rauwolscine HCl) 10 mg CDX-00025512-025 alpha-Yohimbine HCl (Rauwolscine HCl) 25 mg CDX-00001006-010 L-Abrine 10 mg CDX-00001006-050 L-Abrine 50 mg CDX-00001151-005 13-acetyl-9-dihydrobaccatin III 5 mg CDX-00001151-010 13-acetyl-9-dihydrobaccatin III 10 mg CDX-00001121-005 7-Acetylbaccatin III 5 mg CDX-00001121-010 7-Acetylbaccatin III 10 mg CDX-00001302-005 2'-Acetyltaxol 5 mg CDX-00001302-010 2'-Acetyltaxol 10 mg CDX-00001303-005 2',7-Bis-Acetyltaxol 5 mg CDX-00001303-010 2',7-Bis-Acetyltaxol 10 mg CDX-00001304-005 7-Acetyltaxol 5 mg CDX-00001339-010 Aconite standards kit contains: 4 x 10 mg Aconitine Bulleyaconitine A Hypaconitin Lappaconitine CDX-00001340-005 Aconitine 5 mg CDX-00001340-010 Aconitine 10 mg CDX-00001492-050 Ajmalicine HCl 50 mg CDX-00001491-010 Ajmalicine 10 mg CDX-00001491-050 Ajmalicine 50 mg CDX-00001495-010 Ajmaline 10 mg CDX-00001495-025 Ajmaline 25 mg CDX-00001645-001 alpha-Amanitin 1 mg CDX-00001645-010 alpha-Amanitin 10 mg CDX-00001747-005 beta-Amyrin acetate 5 mg CDX-00001740-010 a-Amyrin 10 mg CDX-00001745-010 B-Amyrin 10 mg CDX-00001671-005 Anisatin 5 mg CDX-00011002-005 Aristolochic acid A 5 mg CDX-00011002-010 Aristolochic acid A 10 mg CDX-00011012-005 Aristolochic acid B 5 mg CDX-00011012-010 Aristolochic acid B 10 mg CDX-00011004-005 Aristolochic acid C 5 mg CDX-00001099-005 Aristolochic acid standards kit contains: 3 x 5 mg Aristolochic acid A Aristolochic acid B Aristolochic acid C

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CDX-00001099-010 Aristolochic acid standards kit contains: 3 x 10 mg Aristolochic acid A Aristolochic acid B Aristolochic acid C CDX-00011074-010 Atropine sulfate 10 mg CDX-00011074-025 Atropine sulfate 25 mg CDX-00011075-001 Atropine sulfate 1 g CDX-00011075-010 Atropine sulfate 10 mg CDX-00002003-005 Baccatin I1-Hydroxy 5 mg CDX-00002003-010 Baccatin I1-Hydroxy 10 mg CDX-00002004-005 Baccatin III 5 mg CDX-00002004-010 Baccatin III 10 mg CDX-00002059-010 Belladonna standards kit contains: 5 x 10 mg Homatropine L-Hyoscyamine Atropine sulfate Scopolamine HBr Tropine CDX-00002170-010 N-Benzyloxymethylphenylisoserine ethylester 10 mg CDX-00002170-025 N-Benzyloxymethylphenylisoserine ethylester 25 mg CDX-00002171-010 N-Benzyloxymethylphenylisoserine methylester 10 mg CDX-00002171-025 N-Benzyloxymethylphenylisoserine methylester 25 mg CDX-00002201-010 Berberine chloride 10 mg CDX-00002201-025 Berberine chloride 25 mg CDX-00002200-005 Berberine chloride 5 mg CDX-00002200-010 Berberine chloride 10 mg CDX-00002469-005 Bulleyaconitine A 5 mg CDX-00002469-010 Bulleyaconitine A 10 mg CDX-00003360-005 Cephalomannine 5 mg CDX-00003360-010 Cephalomannine 10 mg CDX-00004462-005 7-Epi-Cephalomannine 5 mg CDX-00004462-010 7-Epi-Cephalomannine 10 mg CDX-00003396-005 Chelerythrine Chloride 5 mg CDX-00003396-010 Chelerythrine chloride 10 mg CDX-00003395-005 Chelerythrine Chloride 5 mg CDX-00003400-010 (+)-Chelidonine Hcl 10 mg CDX-00003406-010 (+)-Chelidonine 10 mg CDX-00003406-025 (+)-Chelidonine 25 mg CDX-00003405-010 (+)-Chelidonine 10 mg CDX-00003405-025 (+)-Chelidonine 25 mg CDX-00003735-005 DL-Coniine HCl 5 mg CDX-00003735-025 DL-Coniine HCl 25 mg CDX-00003730-025 DL-Coniine 25 mg CDX-00003746-010 Convallatoxin 10 mg CDX-00003745-010 Convallatoxin 10 mg CDX-00003745-025 Convallatoxin 25 mg CDX-00003765-010 Coptisine chloride 10 mg CDX-00003770-005 Coptisine chloride 5 mg CDX-00003770-010 Coptisine chloride 10 mg CDX-00003812-010 Corynanthine (Rauhimbine) 10 mg CDX-00003812-025 Corynanthine (Rauhimbine) 25 mg CDX-00003813-025 Corynanthine HCl 25 mg CDX-00003983-005 Cyclopamine 5 mg CDX-00031065-005 Cytisine (Laburnin) 5 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CDX-00031065-010 Cytisine (Laburnin) 10 mg CDX-00004024-005 Danshen Tanshinone standards kit contains: 4 x 5 mg Cryptotanshinone Tanshinone I Tanshinone IIA Dihydrotanshinone CDX-00004024-010 Danshen Tanshinone standards kit contains: 4 x 10 mg Cryptotanshinone Tanshinone I Tanshinone IIA Dihydrotanshinone CDX-00004060-005 10-Deacetyl-7-xylotaxol 5 mg CDX-00004060-010 10-Deacetyl-7-xylotaxol 10 mg CDX-00004066-010 10-Deacetylbaccatin V 10 mg CDX-00004065-005 10-Deacetylbaccatin-III 5 mg CDX-00004065-010 10-Deacetylbaccatin-III 10 mg CDX-00004080-005 7-(Triethylsil)-10-deacetylbaccatin-III 5 mg CDX-00004080-010 7-(Triethylsil)-10-deacetylbaccatin-III 10 mg CDX-00004075-005 13-Deacetyltaxchinin I 5 mg CDX-00004075-010 13-Deacetyltaxchinin I 10 mg CDX-00004078-005 10-Deacetyltaxol B 5 mg CDX-00004078-010 10-Deacetyltaxol B 10 mg CDX-00004079-005 10-Deacetyltaxol C 5 mg CDX-00004079-010 10-Deacetyltaxol C 10 mg CDX-00004059-005 10-Deacetyltaxol 5 mg CDX-00004059-010 10-Deacetyltaxol 10 mg CDX-00004077-005 7-Epi-10-deacetyltaxol 5 mg CDX-00004077-010 7-Epi-10-deacetyltaxol 10 mg CDX-00004076-005 7-Epi-10-oxo-10-deacetyltaxol 5 mg CDX-00004076-010 7-Epi-10-oxo-10-deacetyltaxol 10 mg CDX-00004236-005 Desmethoxyyangonin 5 mg CDX-00004236-010 Desmethoxyyangonin 10 mg CDX-00004461-005 2"",3""-Dihydrocephalomannine 5 mg CDX-00004461-010 2"",3""-Dihydrocephalomannine 10 mg CDX-00004476-005 Dihydrokavain 5 mg CDX-00004476-010 Dihydrokavain 10 mg CDX-00004477-010 Dihydromethysticin 10 mg CDX-00004477-005 Dihydromethysticin 5 mg CDX-00005018-020 Echimidine 20 mg CDX-00005115-005 7-Epitaxol C 5 mg CDX-00005115-010 7-Epitaxol C 10 mg CDX-00005114-010 2'-Epitaxol 10 mg CDX-00005114-025 2'- Epitaxol 25 mg CDX-00005117-010 7-Epitaxol solution (2.4 mg/ml) 10 mL CDX-00005116-005 7-Epitaxol 5 mg CDX-00005116-010 7-Epitaxol 10 mg CDX-00007241-025 Glaucine HBr 25 mg CDX-00007241-100 Glaucine HBr 100 mg CDX-00008041-001 Harmaline HCl 1 g CDX-00008041-100 Harmaline HCl 100 mg CDX-00008040-001 Harmaline 1 g CDX-00008040-100 Harmaline 100 mg CDX-00008051-500 Harmine HCl 500 mg CDX-00008050-025 Harmine HCl 25 mg

170 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CDX-00008050-100 Harmine HCl 100 mg CDX-00008046-100 Harmine 100 mg CDX-00008046-500 Harmine 500 mg CDX-00008045-025 Harmine 25 mg CDX-00008045-100 Harmine 100 mg CDX-00008326-025 Homatropine 25 mg CDX-00008326-010 Homatropine 10 mg CDX-00008624-005 7-hydroxymitragynine 5 mg CDX-00008720-010 3'-P-Hydroxytaxol 10 mg CDX-00008876-010 Hyoscyamine Sulfate 10 mg CDX-00008875-010 L-Hyoscyamine 10 mg CDX-00008875-050 L-Hyoscyamine 50 mg CDX-00008900-005 Hypaconitine 5 mg CDX-00008900-010 Hypaconitine 10 mg CDX-00009025-002 Ibotenic Acid 2 mg CDX-00030964-005 Japanese star anis (Illicium anisatum) fruit VBRM 5 g CDX-00010200-010 Jervine 10 mg CDX-00010200-050 Jervine 50 mg CDX-00011310-005 Kava Kava standards kit contains: 6 x 5 mg Desmethoxyyangonin Dihydrokavain Dihydromethysticin DL-Kavain Methysticin Yangonin CDX-00011310-010 Kava Kava standards kit contains: 6 x 10 mg Desmethoxyyangonin Dihydrokavain Dihydromethysticin DL-Kavain Methysticin Yangonin CDX-00011300-005 DL-Kavain 5 mg CDX-00011300-010 DL-Kavain 10 mg CDX-00011305-001 DL-Kavain 1 g CDX-00031085-001 Kratom Balinese (Mitragyna speciosa) leaf BRM 1 g CDX-00031086-250 Kratom Dominican (Mitragyna speciosa) leaf BRM 250 mg CDX-00012073-005 Lappaconitine 5 mg CDX-00012073-010 Lappaconitine 10 mg CDX-00013860-005 Methysticin 5 mg CDX-00013860-010 Methysticin 10 mg CDX-00013890-005 Mitragynine 5 mg CDX-00013890-010 Mitragynine 10 mg CDX-00013889-005 Mitragynine 5 mg CDX-00013889-010 Mitragynine 10 mg CDX-00013955-005 Mitraphylline 5 mg CDX-00013955-010 Mitraphylline 10 mg CDX-00013907-005 Muscimol 5 mg CDX-00013935-100 Myristicin 100 mg CDX-00013935-010 Myristicin 10 mg CDX-00014378-005 Nitine (Benzyl analog of Taxol) 5 mg CDX-00014378-010 Nitine (Benzyl analog of Taxol) 10 mg CDX-00016011-001 Paclitaxel C13 labeled for non-human use only 1 mg CDX-00016011-005 Paclitaxel C13 labeled for non-human use only 5 mg CDX-00016010-005 Paclitaxel 5 mg

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Drugs and metabolites of forensic and clinical interest

Code Product Unit CDX-00016010-010 Paclitaxel 10 mg CDX-00016316-005 Protoveratrine A 5 mg CDX-00016318-005 Protoveratrine A und B 5 mg CDX-00016317-005 Protoveratrine B 5 mg CDX-00001499-010 Rauwolfia Standards Kit contains: 7 x 10 mg Ajmalicine Ajmaline Corynanthine (Rauhimbine) Reserpine Reserpinic acid HCl Rescinnamine alpha-Yohimbine HCl (Rauwolcine HCl) CDX-00030622-005 Rauwolfia Root BRM 5 g CDX-00018050-001 Rescinnamine 1 g CDX-00018050-010 Rescinnamine 10 mg CDX-00018041-010 Reserpinic acid HCl 10 mg CDX-00018041-025 Reserpinic acid HCl 25 mg CDX-00018040-010 Reserpine 10 mg CDX-00018040-025 Reserpine 25 mg CDX-00018295-005 Ricin (Ricinus communis) VBRM 5 g CDX-00019039-010 Salvinorin A 10 mg CDX-00019039-025 Salvinorin A 25 mg CDX-00019042-001 Salvinorin B 1 g CDX-00019047-005 Salvinorin B 5 mg CDX-00019047-010 Salvinorin B(P) 10 mg CDX-00019050-010 Sanguinarine chloride 10 mg CDX-00019045-010 Sanguinarine chloride 10 mg CDX-00019089-010 Scopolamine HBr (RG) 10 mg CDX-00019089-250 Scopolamine HBr 250 mg CDX-00019135-005 Senecionine 5 mg CDX-00019135-010 Senecionine 10 mg CDX-00019140-005 Seneciphyllin 5 mg CDX-00019140-010 Seneciphyllin 10 mg CDX-00019139-005 Senkirkin (Renardine) 5 mg CDX-00030965-005 Star anis (Illicium verum) fruit VBRM 5 g CDX-00019373-250 Strychnine 250 mg CDX-00019373-100 Strychnine 100 mg CDX-00020042-005 Tanshinone I 5 mg CDX-00020042-010 Tanshinone I 10 mg CDX-00020043-005 Tanshinone IIA 5 mg CDX-00020043-010 Tanshinone IIA 10 mg CDX-00020041-005 Crypto-Tanshinone 5 mg CDX-00020041-010 Crypto-Tanshinone 10 mg CDX-00020075-0SM Taxane (Taxol) standard mixture (13 compound mix) 500 μL CDX-00020062-005 Taxayuntin C 5 mg CDX-00020062-010 Taxayuntin C 10 mg CDX-00020064-005 Taxcultine 5 mg CDX-00020064-010 Taxcultine 10 mg CDX-00020067-005 Taxinine M 5 mg CDX-00020067-010 Taxinine M 10 mg CDX-00020070-005 Taxol C 5 mg CDX-00020070-010 Taxol C 10 mg CDX-00020071-005 Taxol side chain diol 5 mg CDX-00020071-010 Taxol side chain diol 10 mg

172 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Drugs and metabolites of forensic and clinical interest

Code Product Unit CDX-00020072-005 Taxol side chain methylester 5 mg CDX-00020072-010 Taxol side chain methylester 10 mg CDX-00020484-010 Triptolide Standards Kit contains, Triptolide(P), Epitriptolide(P), Triptonide(P), 4 x 10 mg Triptophenolide(P) CDX-00020480-010 Triptolide 10 mg CDX-00020480-050 Triptolide 50 mg CDX-00020481-010 Epi-Triptolide 10 mg CDX-00020481-050 epi-Triptolide 50 mg CDX-00020482-010 Triptonide 10 mg CDX-00020482-050 Triptonide 50 mg CDX-00020483-010 Triptophenolide 10 mg CDX-00020483-050 Triptophenolide 50 mg CDX-00020491-010 Tropine 10 mg CDX-00020491-100 Tropine 100 mg CDX-00022460-005 Veratrine HCl 5 mg CDX-00022460-010 Veratrine HCl 10 mg CDX-00024921-005 7-Xylotaxol C 5 mg CDX-00024921-010 7-Xylotaxol C 10 mg CDX-00024920-005 7-Xylotaxol 5 mg

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Antifungal drugs

Code Product Unit TRC-A511450 Albaconazole 10 mg TRC-A511452 Albaconazole-D3 1 mg TRC-B690272 rac Butoconazole-D5 nitrate 1 mg TRC-B690273 Butoconazole nitrate 10 mg TRC-D288790 2-Desbutyl-2-isopentyl-5-methyl itraconazole 1 mg TRC-F421000 Fluconazole 100 mg TRC-F421002 Fluconazole-D4 1 mg TRC-H943600 Hydroxy itraconazole 1 mg TRC-H943602 Hydroxy Itraconazole-D5 1 mg TRC-H943603 Hydroxy Itraconazole-D8 1 mg TRC-I937500 Itraconazole 50 mg TRC-I937502 Itraconazole-D5 1 mg TRC-K186000 Ketoconazole 500 mg TRC-K186002 Ketoconazole-D8 2.5 mg TRC-K195000 Keto itraconazole 1 mg TRC-L174500 Lanoconazole 10 mg TRC-L174502 Lanoconazole-D3 1 mg TRC-O846800 Oxiconazole nitrate 10 mg TRC-P689600 Posaconazole 1 mg TRC-P689602 Posaconazole-D5 1 mg TRC-V760000 Voriconazole 10 mg TRC-V760002 Voriconazole-D3 1 mg TRC-V760010 Voriconazole N-oxide 1 mg TRC-V760012 Voriconazole-D3 N-oxide 0.5 mg

174 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Antiviral drugs

Code Product Unit TRC-A105000 Abacavir sulfate 5 mg TRC-A105002 Abacavir-D4 1 mg TRC-A105010 Abacavir 5-beta-D-glucuronide 1 mg TRC-A628917 Adefovir-D4, diethyl ester 2.5 mg TRC-A634400 Amprenavir 5 mg TRC-A634402 Amprenavir-D4 1 mg TRC-A790051 Atazanavir 5 mg TRC-A790052 Atazanavir-D5 1 mg TRC-D193500 Darunavir 5 mg TRC-D193502 Darunavir-D9 1 mg TRC-D230625 Delavirdine 10 mg TRC-D230630 Delavirdine mesylate 10 mg TRC-D288690 6-Desamino 6-chloro etravirine 5 mg TRC-D297430 Desthiazolylmethyloxycarbonyl ritonavir 5 mg TRC-D297450 Desthiazolylmethyl ritonavir 5 mg TRC-D440950 2í,3í-Dideoxyinosine 10 mg TRC-D440952 2í,3í-Dideoxyinosine-15N4 0.5 mg TRC-E425000 Efavirenz 10 mg TRC-E555600 Enfuvirtide acetate 100 mg TRC-E425002 rac-Efavirenz-D4 1 mg TRC-E425005 ent Efavirenz 2.5 mg TRC-E525000 Emtricitabine 10 mg TRC-E525002 Emtricitabine-13C,15N2 0.5 mg TRC-E558902 Entecavir-15N3 5 mg TRC-E937000 Etravirine 5 mg TRC-E937002 Etravirine-13C3 1 mg TRC-E937003 Etravirine-D8 1 mg TRC-F335002 Fialuridine-15N2,13C 10 mg TRC-H941820 rac 7-Hydroxy efavirenz 1 mg TRC-H941825 rac 8-Hydroxy efavirenz 1 mg TRC-I525000 Indinavir sulphate 5 mg TRC-I525002 Indinavir-D6 1 mg TRC-L172500 Lamivudine 10 mg TRC-L172502 Lamivudine-15N2,13C 1 mg TRC-L469480 Lopinavir 10 mg TRC-L469482 Lopinavir-D8 1 mg TRC-L469485 Lopinavir metabolite M-1 1 mg TRC-L469490 Lopinavir metabolite M-3/M-4 1 mg TRC-M193000 Maraviroc 2.5 mg TRC-M193002 Maraviroc-D6 1 mg TRC-M325963 N-Methylritonavir bicarbonate 5 mg TRC-N389750 Nelfinavir mesylate 10 mg TRC-N389752 Nelfinavir-D3 1 mg TRC-N391275 Nevirapine 5 mg TRC-N391277 Nevirapine-D5 1 mg TRC-P681000 Podophyllotoxin, 98% 500 mg TRC-R100300 Raltegravir potassium salt 5 mg TRC-R100302 Raltegravir-D3, potassium salt 1 mg TRC-R100310 Raltegravir beta-D-glucuronide 1 mg

Edition 2011/2012 We continually release new ‘legal high’ and ‘designer drug’ standards 175

Molecular biology products

Code Product Unit TRC-R414475 Ribavirin 100 mg TRC-R414477 Ribavirin-13C5 1 mg TRC-R414500 Ribavirin 5í-monophosphate, dilithium salt 5 mg TRC-R517000 Rimantadine HCl 10 mg TRC-R517002 Rimantadine-D4 HCl 1 mg TRC-R535000 Ritonavir 10 mg TRC-R535002 Ritonavir-D6 0.5 mg TRC-R535003 Ritonavir-13C3 0.5 mg TRC-R701700 Rupintrivir 2.5 mg TRC-S135000 Saquinavir mesylate 10 mg TRC-S135002 Saquinavir-D9 1 mg TRC-T016000 Telbivudine 10 mg TRC-T018500 Tenofovir 5 mg TRC-T018502 Tenofovir-D6 1 mg TRC-T018510 Tenofovir diphosphate 1 mg TRC-T412000 Thymidine 25 g TRC-T412003 Thymidine-13C,15N2 1 mg TRC-T412002 Thymidine, methyl-D3 2.5 mg TRC-T412152 Thymine, methyl-D3 10 mg TRC-T444902 Tipranavir-D4 1 mg TRC-T444910 Tipranavir beta-D-glucuronide 1 mg TRC-T444912 Tipranavir-D4 beta-D-glucuronide 0.5 mg TRC-Z148000 Zanamivir 1 mg TRC-Z148002 Zanamivir-D3 5 mg TRC-A825000 Zidovudine (3'-Azido-3'-deoxythymidine) 250 mg TRC-A825002 Zidovudine methyl-D3 (3'-Azido-3'-deoxythymidine,mMethyl-D3) 1 mg

Molecular biology products

Code Product Unit NIST-2372 Human DNA quantitation standard set (3) This material is intended primarily for use in the value assignment of human genomic deoxyribonucleic acid (DNA) forensic quantitation materials. NIST-2372 consists of three well-characterized human genomic DNA materials solubilized in 10 mmol/L Tris HCl and 0.1 mmol/L disodium EDTA) using deionized water adjusted to pH 8.0 (TE-4, pH 8.0 buffer). The three component genomic DNA materials, labeled A, B, and C, are respectively derived from a single male donor, multiple female donors, and multiple male and female donors. Each unit of NIST-2372 consists of one sterile 2-mL vial of each component, each vial containing approximately 110 ¼L of DNA solution. Certified values for decadic attenuance (D10) are provided for the three components at five wavelengths. Information values for the conventional DNA mass concentrations are also provided. Certfied value Wavelength (nm) Component A Component B Component C 230 ...... 0.458 ± 0.024 ...... 0.445 ± 0.024 ...... 0.446 ± 0.025 260 ...... 1.049 ± 0.017 ...... 1.073 ± 0.031 ...... 1.086 ± 0.018 270 ...... 0.859 ± 0.016 ...... 0.875 ± 0.021 ...... 0.893 ± 0.016 280 ...... 0.562 ± 0.014 ...... 0.571 ± 0.016 ...... 0.585 ± 0.015 330 ...... 0.005 + 0.006 ...... 0.005 ± 0.005 ...... 0.005 + 0.009 ...... - 0.005 ...... -0.005

NIST-2390 DNA profiling standard set This material is intended for (1) standardization of forensic and paternity quality assurance procedures for Restriction Fragment Length Polymorphisms (RFLP) testing using HaeIII restriction enzymes, and (2) instructional law enforcement or nonclinical research purposes. It is not intended for any human/animal clinical diagnostic use. This new certificate of the material updates the band size values of the original SRM 2390 certification to reflect the evolution of forensic practice from 1991 to 1998. Each unit consists of 20 components. Quantitative allelic band sizes are provided for human DNA from two sources: (1) the female cell line K562, and (2) the male source “TAW.” Three different forms of material from the two sources are provided: (1) cell pellet, (2) extracted genomic DNA, and (3) a HaeIII restriction digest “pre-cut” DNA. The remaining components are well-characterized consumable materials required for qualitative evaluation of the HaeIII RFLP measurement process. These components include standards for quantifying extracted DNA by use of yield gels, a DNA ladder for band size determination, materials for labeling the DNA size ladder, a viral DNA marker for assessment of electrophoretic separation, and agarose that is compatible with all DNA components.

176 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Molecular biology products

Code Product Unit NIST-2391B PCR based DNA profiling set (12) This material is intended primarily for use in the standardization of forensic and paternity quality assurance procedures for Polymerase Chain Reaction (PCR)-based genetic testing and for instructional law enforcement or non-clinical research purposes. This material can also be used for quality assurance when assigning values to in-house control materials. It is not intended for any human or animal clinical diagnostic use. Note that NIST- 2391b is slightly modified from NIST-2391, in that there is more emphasis on Short Tandem Repeats (STRs) and less emphasis on D1S80 [1,2] reflecting the growing interest and utility of STRs. It is composed of well-characterized human deoxyribonucleic acid (DNA) in two forms: genomic DNA and DNA to be extracted from cells spotted onto filter paper. Each unit is composed of 12 frozen components packaged in one box.

NIST-2392 Mitochondrial DNA sequencing box This material is intended to provide quality control when performing the polymerase chain reaction (PCR) and sequencing of human mitochondrial DNA (mtDNA) for forensic identifications, medical diagnosis, or mutation detection. It may also be used as a control when amplifying (PCR) and sequencing any DNA. It can also be used for quality assurance when assigning values to in-house control materials. It is certified for the sequences of the entire human mtDNA (16 569 base pairs) from two lymphoblastoid cell culture lines (CHR and GM09947A) from apparently normal individuals, plus the cloned HV1 region of CHR containing a C-stretch which is difficult to sequence. The SRM is packaged in a single box containing three components: (1) extracted DNA from cell culture line CHR (tube contains 60 μL of DNA at a concentration of 1 ng/μL); (2) extracted DNA from cell culture line GM09947A (tube contains 60 μL of DNA at a concentration of 1 ng/μL); and (3) cloned DNA from the CHR HV1 region containing the C-stretch (tube contains 10 μL of DNA at a concentration of 100 ng/μL).

NIST-2392-I Mitochondrial DNA sequencing (Human HL-60 DNA) box This material is intended to provide quality control when performing the polymerase chain reaction (PCR) and sequencing of human mitochondrial DNA (mtDNA) for forensic identification, medical diagnosis, or mutation detection. It may also serve as a control when amplifying (PCR) and sequencing any DNA. it can also be used for quality assurance when assigning values to in-house control materials. It is certified for the sequences of the entire human mtDNA (16 569 base pairs) from a promyelocytic cell line (HL-60) prepared from the peripheral blood leukocytes from an individual with acute promyelocytic leukemia. Each unit consists of 65 μL of extracted DNA from cell culture line HL-60 at a nominal concentration of 1.4 ng/μL, which is contained in a vial packaged in a protective plastic box. For details please ask for the data sheet.

NIST-2394 Heteroplasmic Mitochondrial DNA Mutation Detection Standard set (10) (set of 10 tubes) This material is composed of human mitochondrial DNA mixtures which simulate different levels of heteroplasmy and is intended to provide quality control benchmarks for forensic, medical, and DNA scientists to assess the detection sensitivity of low-frequency mutations, single nucleotide polymorphisms (SNPs) in either mitochondrial DNA (mtDNA) or in pooled nuclear DNA samples, or heteroplasmic sites in mtDNA. The product is packaged in a single protective plastic box containing ten tubes: one tube containing the 100 % (by mass) polymorphic DNA, one tube containing the 100 % (by mass) CRS DNA, and eight tubes containing different mass percentages of the polymorphic/CRS mtDNA mixtures (mass % polymorphic levels are 1 %, 2.5 %, 5 %, 10 %, 20 %, 30 %, 40 % and 50 %). Each vial contains 25 μL of DNA at a concentration of 8 ng/μL in 10 mM Tris-HCl, pH 8.5.

NIST-2395 Human Y-Chromosome DNA Profiling Standard box This material is intended primarily for use in the standardization of forensic and paternity quality assurance procedures for Polymerase Chain Reaction (PCR)-based genetic testing and for instructional law enforcement or non-clinical research purposes that involve the human Y-chromosome. It can also be used for quality assurance when assigning values to in-house control materials. It is not intended for any human or animal clinical diagnostic use. It is composed of well-characterized human genomic deoxyribonucleic acid (DNA) in liquid form. Each unit is composed of 6 frozen components packaged in one box, five male samples and one female sample.

NIST-2396 Oxidative DNA Damage Mass Spectrometry Standard set (12) (set of 12 vials) This material is intended for use in the measurement of oxidative DNA damage by gas chromatography/mass spectrometry (GC/MS), and liquid chromatography/mass spectrometry (LC/MS), using the isotope-dilution technique for quantification in both cases. Each unit is a set of twelve stable isotope-labeled components (ten analogues of oxidatively modified DNA bases, one analog of an oxidatively modified nucleoside and one analog of a normal DNA nucleoside) contained in a protective plastic box. Each vial of contains 0.2 mL of a designated component at a specified concentration.

NIST-2399 Fragile X Human DNA Triplet Repeat Standard set (9) This material is intended to provide quality control by serving as a positive control to clinical laboratories that test human samples for Fragile X and who need to determine the number of CGG trinucleotide repeats present in samples. It is composed of human deoxyribonucleic acid (DNA) from fragile X cell lines or patient samples that have been amplified using polymerase chain reaction (PCR) techniques. Each unit consists of a single box containing 9 vials, designated A through I. Each vial contains 20 μL of a frozen PCR product with a different number of CGG repeats suspended in a buffer (10 mM Tris-Cl pH 8.5). The American College of Medical Genetics Guidelines requires a positive control for all genetic testing. In addition to medical diagnoses, the ability to detect the correct number of triplet repeats will help in genetic counseling and genetic research in the area of triplet repeats.NIST-2399 will also help to ensure the accuracy and comparability of results from different laboratories.

IRMM/IFCC-490 PLASMID DNA for prothrombin wildtype (homozygous) vial This material is intended to be used as a negative control material (wildtype sequence) in PCR reactions for the identification of the Factor II (prothrombin) G20210A mutation by diagnostic PCR-derived methods. Each polypropylene vial contains approximately 1 ng plasmid DNA (pIRMM-0001) in a volume of 50 μL of a Tris/EDTA solution (10 mmol/L Tris, 1 mmol/L EDTA, pH 8.0). This solution was obtained after dilution of the stock of 1390 ± 29 μg/mL (concentration ± standard deviation) in Tris/EDTA buffer. The plasmid pIRMM-0001 is a pUC18 vector containing a 609-bp fragment of the human prothrombin gene from nucleotide 26302 to nucleotide 26910 (wildtype sequence) in the GeneBank database (accession number M17262). Certified property: p < 3 x 10-6

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Molecular biology products

Code Product Unit IRMM/IFCC-491 PLASMID DNA for prothrombin mutation (homozygous) vial Each polypropylene vial contains approximately 1 ng plasmid DNA (pIRMM-0002) in a volume of 50 μL of a Tris/EDTA solution (10 mmol/L Tris, 1 mmol/L EDTA, pH 8.0). This solution was obtained after dilution of the stock of 1823 ± 29 μg/mL (concentration ± standard deviation) in Tris/EDTA buffer. The plasmid pIRMM-0002 is a pUC18 vector containing a 609-bp fragment of the human prothrombin gene from nucleotide 26302 to nucleotide 26910 (G->A point mutation at position 26784 in the GeneBank database (accession number M17262)). Another point mutation (A->G) is present at position 26628, but does not influence the genotyping. Certified property: p < 3 x 10-6

IRMM/IFCC-492 PLASMID DNA for prothrombin mutation (homozygous) vial Each polypropylene vial contains approximately 1 ng plasmid DNA (pIRMM-0001 and pIRMM-0002) in a volume of 50 μL of a Tris/EDTA solution (10 mmol/L Tris, 1 mmol/L EDTA, pH 8.0). This solution was obtained after dilution of the stocks (concentration ± standard deviation) of IRMM/IFCC-490 of 1390 ± 29 μg/mL and IRMM/IFCC-491 of 1823 ± 29 μg/mL in Tris/EDTA buffer. The plasmids pIRMM-0001 and pIRMM-0002 are pUC18 vectors containing a 609-bp fragment of the human prothrombin gene from nucleotide 26302 to nucleotide 26910 in the GeneBank database (accession number M17262). They were mixed in equal volumes of identical mass concentrations (wildtype and G20210A point mutation sequences) to mimic a heterozygous control. Certified property: p < 3 x 10-6

178 We continually release new ‘legal high’ and ‘designer drug’ standards Edition 2011/2012

Forensic applications – matrix materials

Matrix materials - drugs in blood, hair, serum, urine

Matrix materials - drugs in blood, hair, serum, urine Anticonvulsant drugs

Code Product Unit NIST-1599 Anticonvulsant drug level assay standard 4 x 5 mL This material is certified for mass concentrations of two anticonvulsant drugs (valproic acid and carbamazepine) in processed human serum base. It is intended for use in the calibration and standardisation of procedures employed in clinical laboratories for the determination of these drugs in serum. It can also be used for critical evaluation of working or secondary reference solutions prepared either in-house or supplied commercially. This material is supplied as a set of four different freeze-dried preparations, three different mass concentrations and a blank. Analytes low medium high Valproic acid ...... 14.5 0.3 ...... 69.1 4.2 ...... 142.5 4.1 μg/mL Carbamazepine ...... 2.8 0.4 ...... 8.8 0.3 ...... 19.4 0.9 μg/mL

NIST-900 Antiepilepsy drug level assay standard 4 x 5 mL This material is certified for mass concentrations of four antiepilepsy drugs (phenytoin, ethosuximide, phenobarbital and primidone) in a processed human serum base. It is intended for use in the calibration and standardisation of procedures employed in clinical laboratories for the determination of these drugs in serum, and for the critical evaluation of working or secondary reference solutions prepared either in-house or supplied commercially. One set contains four bottles with freeze-dried human serum, including a blank (0 μg / mL) and three different concentration levels. Analytes toxic therapeutic sub-therapeutic μg/mL μg/mL μg/mL Phenytonin ...... 60.7 0.9 ...... 16.7 0.3 ...... 4.2 0.1 Ethosuximide ...... 174.7 0.6 ...... 75.9 0.5 ...... 11.8 0.4 Phenobarbital...... 103.6 0.3 ...... 21.6 0.2 ...... 5.3 0.2 Primidone ...... 18.6 0.7 ...... 8.1 0.2 ...... 3.6 0.1 Currently not available

Antidepressiva AC- TDM Antidepressiva in serum, lyophilised TDMD 3/10-A SE 6 x 4 mL SE015.040.020.001 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Antidepressants. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh.

Analytes Target value Duloxetine ...... 29,4 μg/L Fluoxetine ...... 104,2 μg/L Fluvoxamine ...... 100,8 μg/L Mianserine ...... 25,4 μg/L Mirtazapine ...... 45,7 μg/L Paroxetine ...... 20,7 μg/L Reboxetine ...... 76,5 μg/L Sertraline ...... 77,0 μg/L Venlafaxine ...... 216,3 μg/L Desmethylvenlafaxine ...... 217,0 μg/L

AC- TDM Antidepressiva in serum, lyophilised TDMD 3/10-B SE 6 x 4 mL SE015.040.020.002 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Antidepressants. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh.

Analytes ...... Target value [μg/L] Duloxetine ...... 71,3 μg/L Fluoxetine ...... 413,5 μg/L Fluvoxamine ...... 218,7 μg/L Mianserine ...... 121,5 μg/L Mirtazapine ...... 148,8 μg/L Paroxetine ...... 62,1 μg/L Reboxetine ...... 161,7μg/L Sertraline ...... 202,0 μg/L Venlafaxine ...... 357,6 μg/L Desmethylvenlafaxine ...... 389,2 μg/L

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Code Product Unit Antiepileptics AC- TDM Antiepileptics in serum, lyophilised TDMB 3/10-B SE 6 x 4 mL SE015.040.009.001 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with antiepileptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh.

Analytes target values Carbamazepine ...... 2,87 mg/L Felbamate ...... 15,50 mg/L Gabapentine ...... 3,90 mg/L Levetiracetam ...... 4,71 mg/L Oxcarbazepine ...... 1,56 mg/L 10-OH-Carbazepine ...... 5,04 mg/L Pregabaline ...... 2,06 mg/L Tiagabine...... 47,40 mg/L Topiramate ...... 2,47 mg/L Vigabatrine ...... 4,84 mg/L

Barbiturates in serum ME 44401 Thiopental serum control with target values (Medidrug Thiopental S) 2 x 2.5 mL Human seum control with target values for accuracy and precision monitoring of thiopental determinations from serum. Thiopental...... 20.95 mg/L

Benzodiazepines ME 41217 Benzodiazepines in human serum, control with certified values 10 x 2.5 mL (Medidrug BZF 1/06 A S-plus) Lyophilised control serum prepared from human serum for accuracy and precision monitoring of benzodiazepines determinations from human serum. The assay values and confidence ranges were established by a large number of independent institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) Analytes Bromazepam ...... 110.70 μg/L Diazepam...... 462.50 μg/L Clonazepam ...... 71.30 μg/L Nordiazepam ...... 204.50 μg/L

ME 41221 Benzodiazepines, human serum control with reference values 10 x 3 mL (Medidrug BZF 1/09-A S-plus) Lyophilised control serum prepared from human serum for accuracy and precision monitoring of benzodiazepines determinations from human serum. The assay values and confidence ranges were established by a large number of independent institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh Analytes Bromazepam ...... 117.10 μg/L Diazepam...... 410.40 μg/L Temazepam ...... 114.60 μg/L Clonazepam ...... 93.80 μg/L Nordiazepam ...... 307.20 μg/L Zolpidem ...... 70.20 μg/L

ME 41222 Benzodiazepines, human serum control with reference values 10 x 3 mL (Medidrug BZF 1/09-B S-plus) Lyophilised control serum prepared from human serum for accuracy and precision monitoring of benzodiazepines determinations from human serum. The assay values and confidence ranges were established by a large number of independent institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh Analytes 7-Aminoflunitrazepam ...... 33.60 μg/L Norflunitrazepam ...... 21.90 μg/L Flunitrazepam ...... 27.80 μg/L Oxazepam ...... 333.30 μg/L Midazolam ...... 106.40 μg/L Zopiclon ...... 45.30 μg/L

AC- TDM Benzodiazepine in serum, lyophilised BZF 3/10-A SE 6x 3 mL SE015.040.005.003 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with benzodiazepines. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes target value Diazepam ...... 223,8 ng/mL Nordiazepam ...... 268,3 ng/mL Bromazepam ...... 78,6 ng/mL Clonazepam ...... 40,9 ng/mL Temazepam ...... 134,1 ng/mL Zolpidem ...... 98,9 ng/mL

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Matrix materials - drugs in blood, hair, serum, urine

Code Product Unit AC- TDM Benzodiazepine in serum, lyophilised BZF 3/10-B SE 6x 3 mL SE015.040.005.004 for in vitro diagnostic use This product is intended for use as a control material as part of a This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with benzodiazepine. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh.

Analytes target value Flunitrazepam...... 11,3 μg/L Midazolam ...... 418,5 μg/L Norflunitrazepam ...... 16,5 μg/L Oxazepam ...... 108,4 μg/L 7-Aminoflunitrazepam...... 46,0 μg/L Zopiclone ...... 37,1 μg/L Lorazepam ...... x

AC- TDM Benzodiazepine in serum, lyophilised BZF 1/11– A SE 6x 3 mL SE015.040.005.005 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with benzodiazepine. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes target value Alprazolam…………………… ...... 36,0 μg/L Bromazepam………………...... 141,8 μg/L Diazepam…………………… ...... 348,3 μg/L Nordiazepam………………...... 315,0 μg/L Clonazepam………………...... 87,10 μg/L Temazepam………………...... 118,6 μg/L Zolpidem ...... ………………………77,1 μg/L

AC- TDM Benzodiazepine in serum, lyophilised BZF 1/11– B SE 6x 3 mL SE015.040.005.006 for in vitro diagnostic use This product is intended for use as a control material as part of a This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with benzodiazepine. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh.

Analytes target value Flunitrazepam...... 14,2 μg/L Midazolam ...... 108,3 μg/L Norflunitrazepam ...... 18,4 μg/L Oxazepam ...... 241,2/L 7-Aminoflunitrazepam...... 25,6 μg/L Zopiclone ...... 43,9 μg/L Lorazepam ...... 120,9 μg/L

ME 41703 Benzodiazepines in human serum, level 1 10 x 2.5 mL Lyophilised human serum control with mean values for accuracy or precision control of benzodiazepines determinations from serum. The concentration values have been determined by independent laboratories of forensic medicine. Analytes 7-Aminoflunitrazepam...... 10 μg/L Flunitrazepam ...... 10 μg/L Bromazepam ...... 100 μg/L Lorazepam ...... 20 μg/L Clonazepam ...... 20 μg/L Midazolam ...... 50 μg/L Nordiazepam ...... 100 μg/L Oxazepam ...... 100 μg/L Diazepam ...... 100 μg/L

ME 41704 Benzodiazepines in human serum, level 2 10 x 2.5 mL Lyophilised human serum control with mean values for accuracy or precision control of benzodiazepines determinations from serum. The concentration values have been determined by independent laboratories of forensic medicine. Analytes 7-Aminoflunitrazepam...... 50 μg/L Flunitrazepam ...... 50 μg/L Bromazepam ...... 400 μg/L Lorazepam ...... 100 μg/L Clonazepam ...... 100 μg/L Midazolam ...... 200 μg/L Nordiazepam ...... 600 μg/L Oxazepam ...... 600 μg/L Diazepam ...... 600 μg/L

Benzoylecgonine NIST-1508A Benzoylecgonine (cocaine metabolite) in freeze-dried urine 4 x 10 mL This material is intended primarily for the determination of benzoylecgonine (cocaine metabolite) in human urine. It consists of four bottles of freeze dried urine, one bottle each of three different levels of benzoylecgonine plus one bottle of blank freeze dried urine (not detected). Analyte low medium high Benzoylecgonine ...... 78.1 4.0 ...... 161 6.8 ...... 315 15 ng/mL

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Code Product Unit Buprenorphines ME 40011 Buprenorphines in human serum level 2 2 x 2.5 mL (Medidrug Buprenorphin S) Lyophilised human serum controls with mean values of two buprenorphines for accuracy or precision control of buprenorphines determinations from serum. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Buprenorphine ...... 2.0 μg/L Norbuprenorphine ...... 5.0 μg/L

ME 40012 Buprenorphines in human serum, level 2 2 x 2.5 mL (Medidrug Buprenorphin S) Lyophilised human serum controls with mean values of two buprenorphines for accuracy or precision control of buprenorphines determinations from serum. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Buprenorphine ...... 13.05μg/L Norbuprenorphine ...... 12.87μg/L

ME 40051 Buprenorphine in human urine cal 1 (1 ng/mL) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 1.03 ng/mL

ME 40052 Buprenorphine in human urine cal 2 (5 ng/L) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 5.47 ng/mL

ME 40053 Buprenorphine in human urine cal 3 (10 ng/L) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 10.69 ng/mL

ME 40054 Buprenorphine in human urine cal 4 (20 ng/L) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 22.53 ng/mL

ME 40055 Buprenorphine in human urine 5 (80 ng/L) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 83.52 ng/mL

ME 40056 Buprenorphine in human urine cal 6 (200 ng/L) 2 x 2.5 mL (Medidrug BUP U-cal) Assayed value ...... 223.74 ng/mL

ME 40131 Buprenorphines in human urine, level 1 new, lot 10802 2 x 2.5 mL (Medidrug BUP U) Lyophilised human urine control in two different concentrations for accuracy control of Buprenorphine determinations from urine. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Buprenorphine ...... 4.76 μg/mL Norbuprenorphine ...... 10.65 μg/mL

ME 40132 Buprenorphines in human urine, level 2 2 x 2.5 mL (Medidrug BUP U) Lyophilised human urine control in two different concentrations for accuracy control of Buprenorphine determinations from urine. The concentration values have been determined by independent laboratories of forensic medicine. Analytes Buprenorphine ...... 18.99 ng/mL Norbuprenorphine ...... 78.17 ng/mL

Cannabinoids NIST-1507B THC-COOH in freeze dried urine set (3) This material is intended primarily for verifying the accuracy of methods used for the determination of 11-nor- delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-9-COOH) in human urine. It consists of three bottles of freeze-dried urine: two bottles, each containing a different certified concentration of THC-9-COOH and one bottle of a urine blank (XD: <1). The contents of each bottle must be reconstituted with 20.0 mL of organic-free or HPLC-grade water. Analyte low medium THC-9-COOH ...... 11.7 1.4 ...... 24.1 1.3 ng/mL

CDT REC-21014 CDT (carbohydrate deficient transferrin) - test solution 15 mL

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Matrix materials - drugs in blood, hair, serum, urine

Code Product Unit Cotinine NIST-RM 8444 Cotinine in human urine 4 x 5 mL This standard is intended primarily for use in validating methods for the determination of cotinine in human urine. One set consists of four vials, each containing cotinine in 5 ml human urine, which has been freeze dried. Two vials are “blank” concentration levels, typical for non-smokers without exposure to cigarette smoke, one vial is a “low” concentration level corresponding to non-smokers with passive exposure to side-stream smoke, and one vial is a “high” level, typical of smokers. Analyte blank low high ng/mL ng/mL ng/mL Cotinine ...... 0.8 ...... 54 ...... 488

Meperidine ME 43303 Medidrug MEP SF 1/09-NI S-plus 2 x 2.5 mL Liquid serum control with reference values (SFTA) prepared from human blood with constituents of human origin and Meprobamate for accuracy and precision monitoring of Meprobamate determinations from serum. Meprobamate...... 19.9 μg/mL

ME 43304 Medidrug MEP SF 1/09-NII S-plus 2 x 2.5 mL Liquid serum control with reference values (SFTA) prepared from human blood with constituents of human origin and Meprobamate for accuracy and precision monitoring of Meprobamate determinations from serum. Meprobamate...... 116.6 μg/mL

Metabolites and substrates in urine ME 41079 Ethylglucuronide, human urine control with reference values 10 x 2.5 mL (Medidrug ETG 1/08-B U-plus) Lyophilised serum control prepared from human urine for accuracy and precision monitoring of ethyl glucuronide and ethyl sulfate determinations in urine. The reference value ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh. reference value Ethyl glucuronide ...... 0.350 mg/L

Neuroleptics AC- Neuroleptica in serum, lyophilised TDMA 3/10-A SE 6x 3 mL SE015.040.015.001 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes Target value Clozapine ...... 249,2 μg/L Desmethyclozapine ...... 236,6 μg/L Olanzapine ...... 17,9 μg/L Quetiapine ...... 74,3 μg/L Amisulpride ...... 157,2 μg/L AC- Neuroleptica in serum, lyophilised TDMA 3/10-B SE 6x 3 mL SE015.040.015.002 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes Target value Clozapine ...... 749,6 μg/L Desmethyclozapine ...... 700,6 μg/L Olanzapine ...... 62,0 μg/L Quetiapine ...... 305,1 μg/L Amisulpride ...... 387,4 μg/L

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Code Product Unit AC- Neuroleptica in serum, lyophilised TDMA 3/10-C SE 6x 3 mL SE015.040.015.003 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes Target value Perazine ...... 51,50 μg/mL Risperidone ...... 4,83 μg/mL 9-OH-Risperidone ...... 24,3 μg/mL Ziprasidone ...... 48,80 μg/mL Citalopram...... 49,90 μg/mL

AC- Neuroleptica in serum, lyophilised TDMA 3/10-D SE 6x 3 mL SE015.040.015.004 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with Neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes Target value Perazine ...... 323,5 μg/mL Risperidone ...... 10,25 μg/mL 9-OH-Risperidone ...... 100,3 μg/mL Ziprasidone ...... 125,3 μg/mL Citalopram...... 253,2 μg/mL

AC- Neuroleptica in serum, lyophilised TDMC 3/10-A SE 6 x 4 mL SE015.040.015.005 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of the proficiency testing of the GTFCh. Analytes Target value] Aripiprazol ...... 50,80 μg/L Flupentixol...... 2,22 μg/L Fluphenazine ...... 1,70 μg/L Haloperidol ...... 4,23 μg/L Sertindol ...... 12,50 μg/L Sulpiride ...... 133,40 μg/L Zotepine ...... 40,00 μg/L

AC- Neuroleptica in serum, lyophilised TDMC 3/10-B SE 6 x 4 mL SE015.040.015.006 for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with neuroleptics. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of the proficiency testing of the GTFCh. Analytes Target value Aripiprazol ...... 175,90 μg/L Flupentixol...... 8,30 μg/L Fluphenazine ...... 6,13 μg/L Haloperidol ...... 24,20 μg/L Sertindol ...... 72,90 μg/L Sulpiride ...... 525,10 μg/L Zotepine ...... 125,00 μg/L Opiates NIST-2381 Morphine and codeine in urine set (4) This material is intended primarily for verifying the accuracy of methods used for the determination of morphine and codeine in human urine. One set consists of four bottles of freeze-dried urine: one bottle each of three different analyte levels plus one bottle of blank urine (XD: < 1). Analytes low medium high ng/mL ng/mL ng/mL Morphine ...... 134 14 ...... 295 12...... 580 18 Codeine ...... 130 5 ...... 282 9...... 560 23

NIST-2382 Morphine glucuronide in freeze dried urine set (4) This material is intended primarily for verifying the accuracy of methods used for the determination of morphine that is present as a glucuronide in human urine. One set consists of four bottles of freeze-dried urine: one bottle each of three different analyte levels plus one bottle of blank urine (XD: <1). The certified mass concentrations for morphine glucuronide in the reconstituted urine are given below as free morphine. Analyte low medium high Morphine ...... 209 20 ...... 437 21...... 853 39 ng/mL

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Matrix materials - drugs in blood, hair, serum, urine

Code Product Unit Drugs used in opiate substitution therapies ME 44505 Replacement drugs in human serum, certified reference control 2 x 2.5 mL (Medidrug STM 2/09-A S-plus) Lyophilised human serum control with reference values for accuracy and precision monitoring of replacement drugs determinations in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analytes Buprenorphine ...... 1.8 μg/L EDDP ...... 119.6 μg/L Norbuprenorphine ...... 22.0 μg/L Methadone ...... 51.0 μg/L

AC-SE015.040.001 Drugs of substitution STM 3/10-A SE serum 6 x 2.5 ml This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with drugs and metabolites associated with opiate replacement therapies. The concentrations of the drugs and metabolites lie within the expected treatment ranges. Analytes target value Burprenorphine ...... 3,40 μg/mL EDDP ...... 47,40 μg/mL Norbuprenotphine ...... 11,80 μg/mL (2-Ethyliden-1,5-dimethyl-3,3-diphenylpyrrolidin / 2-ethylidene-1,5-dimethyl- 3,3-diphenyl-pyrrolidine) Methadon ...... 115,30 μ/mL

AC-SE015.040.002 Drugs of substitution STM 3/11-A SE serum 6 x 2.5 ml This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with drugs and metabolites associated with opiate replacement therapies. The concentrations of the drugs and metabolites lie within the expected treatment ranges. Analytes target value Burprenorphine...... 2,5 μg/mL Norbuprenotphine...... 16,7 μg/mL Methadon...... 94,0 μg/mL EDDP...... 60,5 μg/mL ME 44103 Replacement drugs in human urine, certified reference control 2 x 2.5 mL (Medidrug STM 1/06-B U-plus) Lyophilised human urine control with values certified by proficiency testing for accuracy and precision monitoring of replacement drugs determinations in urine. Each control lot has been produced especially for the external quality controls organised by the GFTCh. The nominal values have been determined by interlaboratory test. Analytes Buprenorphine ...... 11.20 μg/L EDDP ...... 199.50 μg/L Norbuprenorphine ..... 25.90 μg/L Methadone ...... 263.80 μg/L

ME 44104 Replacement drugs in human urine, certified reference control 2 x 2.5 mL (Medidrug STM 2/09-B U-plus) Lyophilised human urine control with reference values for accuracy and precision monitoring of replacement drugs determinations in urine. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analytes Buprenorphine ...... 11.0 μg/L EDDP ...... 120.60 μg/L Norbuprenorphine ...... 26.7 μg/L Methadone ...... 246.50 μg/L

AC-UR015.040.001 Drugs of substitution STM 3/10-B UR urine 6 x 2.5 ml for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human urine with drugs and metabolites associated with opiate replacement therapies. The concentrations of the drugs and metabolites lie within the expected treatment ranges. Analytes target value Burprenorphine ...... 12,60 μg/mL EDDP ...... 127,00 μg/mL Norbuprenotphine ...... 26,50 μg/mL Methadon ...... 99,90 μg/mL

AC-UR015.040.002 Drugs of substitution STM 1/11-B UR urine 6 x 2.5 ml for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human urine with drugs and metabolites associated with opiate replacement therapies. The concentrations of the drugs and metabolites lie within the expected treatment ranges. Analytes target value Burprenorphine………………………….14,0 μg/mL Norbuprenotphine………………………35,2 μg/mL Methadon...... 107,4 μg/mL EDDP...... 162,1 μg/mL

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Code Product Unit Therapeutic drug monitoring Seronorm pharmaca (serum controls for clinical chemistry) The Seronorm Pharmaca materials are intended for checking precision of methods routinely used for therapeutic drug monitoring. It is available at two levels (L-1 and L-2), containing an animal-based matrix spiked with more than 30 drugs. No stabilisers or preservatives are added. Unopened vials can be stored for three years at 2-8 °C. After opening, the material is stable for seven days at 2-8 °C. The materials can be frozen in small portions. Components: Amikacin Digoxin Methotrexate Quinidine Amiodarone Disopyramide Netilmicin (only L-1) Salicylate Caffeine Ethosuximide Nortriptyline Theophylline Carbamezepine Flecainide Paracetamol Tobramycin Chloramphenicol Gentamycin Phenobarbital Valproic Acid Clonazepam Haloperidol Phenytoin Vancomycin Cyklosporine Imipramine Primidone Desipramine Lidocaine Procainamide Diazepam Lithium Propanolol

SERO101405 Seronorm Pharmaca L-1 10 x 5 mL (serum control for clinical chemistry) SERO101505 Seronorm Pharmaca L-2 10 x 5 mL (serum control for clinical chemistry) ME 41413 Therapeutic drug monitoring, human serum control with reference values 5 x 3 mL (Medidrug TDMA 2/09-A S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Amisulprid ...... 126.0 μg/L Olanzapine ...... 21.0 μg/L Clozapine ...... 115.3 μg/L Quetiapine ...... 51.9 μg/L N-Desmethylclozapine ...... 110.1 μg/L

ME 41414 Therapeutic drug monitoring, human serum control with reference values 5 x 3 mL (Medidrug TDMA 2/09-B S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Amisulprid ...... 325.3 μg/L Olanzapine ...... 27.7 μg/L Clozapine ...... 411.8 μg/L Quetiapine ...... 181.4 μg/L N-Desmethylclozapine ...... 334.9 μg/L

ME 41415 Therapeutic drug monitoring, human serum control with reference values 5 x 3 mL (Medidrug TDMA 2/09-C S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Citalopram...... 47.0 μg/L 9-Hydroxy-risperidone...... 25.6 μg/L Perazine ...... 90.4 μg/L Ziprasidone ...... 31.8 μg/L Risperidone ...... 4.7 μg/L

ME 41416 Therapeutic drug monitoring, human serum control with reference values 5 x 3 mL (Medidrug TDMA 2/09-D S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Citalopram...... 167.3 μg/L 9-Hydroxy-risperidone...... 102.3 μg/L Perazine ...... 297.8 μg/L Ziprasidone ...... 90.1 μg/L Risperidone ...... 9.1 μg/L

ME 41430 Therapeutic drug monitoring, human serum control with reference values 5 x 4 mL (Medidrug TDMC 2/09-A S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Aripiprazol ...... 59.9 μg/L Sertinol * ...... 20.0 μg/L Flupentixol...... 2.4 μg/L Sulpirid ...... 113.9 μg/L Fluphenazine ...... 2.1 μg/L Zotepine* ...... 45.0 μg/L Haloperidol ...... 7.6 μg/L *) can be used as precision control, only

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Code Product Unit ME 41431 Therapeutic drug monitoring, human serum control with reference values 5 x 4 mL (Medidrug TDMC 2/09-B S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Aripiprazol ...... 195.5 μg/L Sertinol * ...... 65.0 μg/L Flupentixol ...... 6.0 μg/L Sulpirid ...... 454.8 μg/L Fluphenazine ...... 6.7 μg/L Zotepine* ...... 130.0 μg/L Haloperidol ...... 19.7 μg/L *) can be used as precision control, only

ME 41470 Therapeutic drug monitoring, human serum control, with reference values 5 x 4 mL (Medidrug TDMD 2/09-A S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Duloxetine ...... 34.5 μg/L Paroxetine ...... 34.9 μg/L Fluoxetine ...... 142.4 μg/L Reboxetine ...... 76.1 μg/L Fluvoxamine ...... 83.8 μg/L Sertraline ...... 45.6 μg/L Mianserine ...... 50.4 μg/L Venlafaxin ...... 243.0 μg/L Mirtazepine ...... 29.6 μg/L Desmethylvenlafaxin ...... 164.6 μg/L

ME 41471 Therapeutic drug monitoring, human serum control, with reference values 5 x 4 mL (Medidrug TDMD 2/09-B S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Duloxetine ...... 55.8 μg/L Paroxetine ...... 79.3 μg/L Fluoxetine ...... 420.0 μg/L Reboxetine ...... 126.7 μg/L Fluvoxamine ...... 168.3 μg/L Sertraline ...... 161.3 μg/L Mianserine ...... 138.1 μg/L Venlafaxin ...... 371.2 μg/L Mirtazepine ...... 119.5 μg/L Desmethylvenlafaxin ...... 362.3 μg/L

ME 41472 Therapeutic drug monitoring, human serum control, with reference values 5 x 4 mL (Medidrug TDMD 2/09-A S-plus) Lyophilised human serum control with reference values for accuracy and precision control for therapeutic drug monitoring in serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Duloxetine ...... 68.60 μg/L Paroxetine ...... 59.60 μg/L Fluoxetine ...... 418.60 μg/L Reboxetine ...... 217.10 μg/L Fluvoxamine ...... 226.70 μg/L Sertraline ...... 174.90 μg/L Mianserine ...... 127.70 μg/L Venlafaxin ...... 368.80 μg/L Mirtazepine ...... 148.30 μg/L Desmethylvenlafaxin ...... 330.80 μg/L

Tricyclic antidepressants ME 42916 Tricyclic antidepressants in serum, certified reference control 10 x 2.5 mL (Medidrug TCA 1/06-B S-plus) Lyophilised serum control prepared from human serum for accuracy and precision monitoring of tricyclic antidepressant determinations in serum. The assay values and confidence ranges were established by a large number of independent institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh Analytes Amitriptyline ...... 354.30 μg/L Nordoxepine ...... 306.90 μg/L Doxepine ...... 368.80 μg/L Nortriptyline ...... 213.60 μg/L

ME 42919 Tricyclic antidepressants, human serum control with reference values 10 x 2.5 mL (Medidrug TCA 2/07-A S-plus) Lyophilised human serum control for accuracy and precision monitoring of tricyclic antidepressant determinations in serum. The reference values were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analyte Amitriptyline ...... 81.2 μg/L Nordoxepine ...... 113.7 μg/L Doxepine ...... 62.5 μg/L Nortriptyline ...... 80.5 μg/L

ME 42920 Tricyclic antidepressants, human serum control with reference values 10 x 2.5 mL (Medidrug TCA 2/07-B S-plus) Lyophilised human serum control for accuracy and precision monitoring of tricyclic antidepressant determinations in serum. The reference values were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analyte Amitryptilin ...... 299.3 μg/L Nordoxepin ...... 205.6 μg/L Doxepin ...... 158.9 μg/L Nortryptilin ...... 185.9 μg/L

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Code Product Unit ME 42921 Tricyclic antidepressants, human serum control with reference values 10 x 2.5 mL (Medidrug TCA 1/10-A S-plus) Lyophilised human serum control for accuracy and precision monitoring of tricyclic antidepressant determinations in serum. The reference values were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analyte Amitryptilin ...... 83.00 μg/L Nordoxepin ...... 118.90 μg/L Trimipramine ...... 72.40 μg/L Doxepin ...... 70.60 μg/L Nortryptilin ...... 84.70 μg/L

ME 42922 Tricyclic antidepressants, human serum control with reference values 10 x 2.5 mL (Medidrug TCA 1/10-C S-plus) Lyophilised human serum control for accuracy and precision monitoring of tricyclic antidepressant determinations in serum. The reference values were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry). Analyte Clomipramine ...... 67.60 μg/L Imipramine ...... 146.30 μg/L Maprotiline ...... 88.60 μg/L Desipramine ...... 138.10 μg/L Norclomipramine ...... 78.20 μg/L

Various drugs of abuse ME 42606 Drugs of abuse in human whole blood, control with reference values 10 x 2.5 mL (Medidrug BTMF 3/09-C VB-Plus) Lyophilised human blood control prepared from human blood with constituents of drugs of abuse. With reference values for accuracy and precision monitoring of drugs of abuse determinations from human whole blood. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing and released by the GTFCh. Analytes Amphetamine ...... 98.4 μg/L Ecgoninmethylester ...... 43.0 μg/L MDA ...... 76.9 μg/L Morphine ...... 33.7 μg/L MDE (MDEA) ...... 56.4 μg/L Codeine ...... 149.0 μg/L MDMA (Ecstasy) ...... 56.7 μg/L Dihydrocodeine ...... 168.0 μg/L Methamphetamine ...... 126.9 μg/L 9-THC ...... 2.9 μg/L MBDB ...... 63.1 μg/L 11-Hydroxy-9-THC...... 2.5 μg/L Cocaine ...... 51.4 μg/L 11-Nor-9-THC COOH ...... 44.2 μg/L Benzoylecgonine ...... 145.8 μg/L

LGCFOR9887.01 Drugs of abuse in human hair - DHF 2/10 250 mg Accuracy control for the internal quality assurance in the laboratory. The control is prepared of ground human hair spiked with drugs of abuse. The target values are in practice-oriented ranges. The target values were determined within the proficiency test DHF 2 / 10 - drugs in hair of the GTFCh under the organizational management of ARVECON GmbH. Requirements for sample preparation and analysis method were not prescribed. Analyses were performed by the participants with GC/MS (/MS) and LC/MS(/MS). The target values were released by the coordinator of the proficiency testing of the GTFCh Analyte target value 9-Tetrahydrocannabinol ...... 0.68 ng/mg MDEA ...... 0.60 ng/mg Cannabinol ...... 0.68 ng/mg Cocaine ...... 2.80 ng/mg Cannabidiol ...... 0.63 ng/mg Benzoylecgonine ...... 3.69 ng/mg Amphetamine ...... 1.41 ng/mg Morphin ...... 1.06 ng/mg Methamphetamine ...... 1.02 ng/mg 6-Monoacetylmorphine ...... 0.26 ng/mg MDMA ...... 3.07 ng/mg Methadone ...... 2.77 ng/mg MDA ...... 0.98 ng/mg EDDP ...... 0.63 ng/mg

AC-HA015.045.002 Drugs of abuse in human hair -DHF 3/10-A HA 250 mg Accuracy control for the internal quality assurance in the laboratory. The control is prepared of ground human hair spiked with drugs of abuse.The target values are in practice-oriented ranges. Before any analysis no washing steps should be done, as this can lead to a decrease of the concentration of the analytes. Considering this restriction the control material can be prepared like a patient sample. The target values were released by the coordinator of the proficiency testing of the GTFCh. Analytes target value Amphetamine ...... 1,14 ng/mg Methamphetamine ...... 0,71 ng/mg MDMA ...... 1,78 ng/mg MDA ...... 0,43 ng/mg MD(E)A ...... 0,59 ng/mg Cocaine ...... 3,17 ng/mg Benzoylecgonine ...... 2,93 ng/mg Morphine ...... 0,82 ng/mg MAM 6-Monoacetylmorphine...... 1,20 ng/mg Methadone ...... 1,80 ng/mg ED ...... 0,49 ng/mg THC9-Tetrahydrocannabinol ...... 0,43 ng/mg CBN Cannabinol ...... 0,81 ng/mg CBD Cannabidiol ...... 0,73 ng/mg Tramadol ...... 1,33 ng/mg

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Code Product Unit NIST-2379 Drugs of abuse in human hair I 100 mg This Standard Reference Material (SRM) is intended primarily for use in validating methods for determining cocaine (COC), benzoylecgonine (BZE), cocaethylene (CE), amphetamine (AMP), methamphetamine (MAMP), and phencyclidine (PCP) in human hair and similar materials. This SRM can also be used for quality assurance when assigning values to in-house control materials. The SRM is a drug-free human hair material, to which drugs of abuse have been incorporated. A unit of SRM 2379 consists of one bottle containing approximately 100 mg of hair segments. Certified concentrations (mass fraction) Analytes Amphetamine...... 6.00 ± 0.32 ng/mg Benzoylecgonine ...... 4.01 ± 0.31 ng/mg Cocaethylene ...... 2.67 ± 0.24 ng/mg Cocaine ...... 7.45 ± 0.40 ng/mg Methamphetamine ...... 5.20 ± 0.27 ng/mg Phencyclidine...... 6.24 ± 0.42 ng/mg Currently not available

NIST-2380 Drugs of abuse in human hair II 100 mg This standard reference material is intended primarily for use in validating methods for determining morphine (MOR), codeine (COD), 6-monoacetylmorphine (MAM), and tetrahydrocannabinol (THC) in human hair and similar materials. This material can also be used for quality assurance when assigning values to in-house control materials. The standard is a drug-free human hair material, to which drugs of abuse have been incorporated. A unit consists of one bottle containing approximately 100 mg of hair segments. Certified concentrations (mass fraction) Analyte Codeine ...... 9.82 ± 0.70 ng/mg Morphine ...... 10.54 ± 0.68 ng/mg 6-Monoacetylmorphine ...... 2.71 ± 0.30 ng/mg Tetrahydrocannabinol ...... 0.99 ± 0.10 ng/mg Currently not available

ME 41652 Drugs of abuse in human serum, human serum control with reference values 10 x 2.5 mL (BMTF 1/10-B S-plus) Lyophilised human serum control prepared from human blood with constituents of drugs of abuse. With reference values for accuracy and precision monitoring of drugs of abuse determinations from serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Amphetamine...... 24.30 μg/L Ecgoninmethylester ...... 12.00 μg/L MDA ...... 26.20 μg/L Morphine ...... 11.40 μg/L MDE (MDEA) ...... 24.60 μg/L Codeine ...... 10.60 μg/L MDMA (Ecstasy) ...... 24.80 μg/L Dihydrocodeine ...... 47.30 μg/L Methamphetamine ...... 26.00 μg/L 9-THC ...... 1.10 μg/L MBDB ...... 25.40 μg/L 11-Hydroxy-9-THC ...... 1.10 μg/L Cocaine ...... 14.10 μg/L 11-Nor-9-THC COOH ...... 13.50 μg/L Benzoylecgonine ...... 46.20 μg/L

ME 41653 Drugs of abuse in human serum, human serum control with reference values 10 x 2.5 mL (BTMF 2/10-B S-plus) Lyophilised human serum control prepared from human blood with constituents of drugs of abuse. With reference values for accuracy and precision monitoring of drugs of abuse determinations from serum. The reference values ranges were established by institutions of forensic medicine within the bounds of external proficiency testing by the GTFCh (Association of Toxicological and Forensic Chemistry) and released by the GTFCh. Analytes Amphetamine...... 143,70 μg/L MDA...... 104,20 μg/L MDE (MDEA)...... 148,80 μg/L MDMA (Ecstasy)...... 143,40 μg/L Methamphetamine ...... 154,60 μg/L MBDB...... 91,50 μg/L Cocaine...... 90,20 μg/L Benzoylecgonine…………………………462,00 μg/L Ecgoninmethylester……………………….66,70 μg/L Morphine...... 91,30 μg/L Codeine...... 101,30 μg/L Dihydrocodeine...... 199,90 μg/L 9-THC...... 17,50 μg/L 11-Hydroxy-9-THC………………………..9,20 μg/L 11-Nor-9-THC COOH …………………135,90 μg/L

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Code Product Unit AC-SE015.015.001 Drugs of abuse in serum, lyophilized - BTMF 3/10-C 10 x 2.5 mL for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with drugs of abuse. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes target value Amphetamine ...... 23,5 μg/L Methamphetamine ...... 23,8 μg/L MDMA ...... 24,3 μg/L MDA ...... 4,1 μg/L MDEA ...... 24,1 μg/L MBDB ...... 23,5 μg/L Cocaine ...... 11,1 μg/L Benzoylecgonine ...... 47,9 μg/L Ecgoninemethyl ester ...... 10,6 μg/L Codeine ...... 10,6 μg/L Morphine ...... 9,6 μg/L Dihydrocodeine ...... 47,2 μg/L 9-Tetrahydrocannabinol ...... 1,1 μg/L 11-OH-9-Tetrahydrocannabinol ...... 1,1 μg/L 11-nor-9-THC carbonic acid ...... 9,5 μg/L

AC-SE015.015.003 Drugs of abuse in serum, lyophilized - BTMF 1/11-B SE 10 x 2.5 mL for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human serum with drugs of abuse. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh. Analytes target value Amphetamine ...... 140,3 μg/L Ecgoninemethyl ester ...... 98,9 μg/L Methamphetamine ...... 140,9 μg/L Codeine ...... 95,8 μg/L MDMA ...... 147,4 μg/L Morphine ...... 99,3 μg/L MDA ...... 97,3 μg/L Dihydrocodeine ...... 185,3 μg/L MDEA ...... 146,0 μg/L 9-Tetrahydrocannabinol ...... 19,9 μg/L MBDB ...... 93,4 μg/L 11-OH-9-Tetrahydrocannabinol ...... 9,8 μg/L Cocaine ...... 100,4 μg/L 11-nor-9-THC carbonic acid ...... 135,9 μg/L Benzoylecgonine ...... 412,7 μg/L

ME 40531 Drugs and medicaments, cut-off - 25 % human urine screening control with target values 9 x 5 mL Lyophilised human urine control (Medidrug U-Screen) prepared from human urine with target values intended for the use as quality control to monitor the performance of urine toxicology confirmatory procedures by determination of drugs of abuse and drugs. Analyte cut off - 25% cut off Amphetamine ...... 500 ...... 375 ng/ml Benzoylecgonine ...... 300 ...... 225 ng/ml Morphine ...... 300 ...... 225 ng/ml Oxazepam...... 200 ...... 150 ng/ml Secobarbital ...... 200 ...... 150 ng/ml 11-Nor-9-THC COOH ...... 50 ...... 37.50 ng/ml Phencyclidine (PCP) ...... 25 ...... 18.75 ng/ml LSD ...... 1 ...... 0.75 ng/ml Methadone ...... 300 ...... 225 ng/ml EDDP ...... 300 ...... 225 ng/m Methaqualone ...... 300 ...... 225 ng/ml Propoxyphen ...... 300 ...... 225 ng/ml Buprenorphine ...... 5 ...... 3.75 ng/ml

ME 40532 Drugs and medicaments, cut-off + 25 % human urine screening control with target values 9 x 5 mL Lyophilised human urine control (Medidrug U-Screen) prepared from human urine with target values intended for the use as quality control to monitor the performance of urine toxicology confirmatory procedures by determination of drugs of abuse and drugs. Analyte cut off + 25% cut off Amphetamine ...... 500 ...... 625 ng/ml Benzoylecgonine ...... 300 ...... 375 ng/ml Morphine ...... 300 ...... 375 ng/ml Oxazepam...... 200 ...... 250 ng/ml Secobarbital ...... 200 ...... 250 ng/ml 11-Nor-9-THC COOH ...... 50 ...... 62.5 ng/ml Phencyclidine (PCP) ...... 25 ...... 31.25 ng/ml LSD ...... 1 ...... 1.25 ng/ml Methadone ...... 300 ...... 375 ng/ml EDDP ...... 300 ...... 375 ng/ml Methaqualone ...... 300 ...... 375 ng/ml Propoxyphen ...... 300 ...... 375 ng/ml Buprenorphine ...... 5 ...... 6.25 ng/ml

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Matrix materials - drugs in blood, hair, serum, urine

Code Product Unit ME 40572 Drug U-confirmation, cut-off + 25 % drugs and medicaments urine confirmation control with 9 x 5 mL target values Lyophilised urine control (Medidrug U-Confirmation) prepared from human urine containing drugs and medicaments with target values. It is intended for the use as quality control to monitor the performance of urine toxicology confirmatory procedures by determination of drugs of abuse and drugs. Analyte cut off + 25% cut off Amphetamine...... 200 ...... 250 ng/mL d-Methamphetamine ...... 200 ...... 250 ng/mL MDA (3,4-Methylendioxyamphetamine) ...... 200 ...... 250 ng/mL MDEA ...... 200 ...... 250 ng/mL (3,4-Methylendioxy-N-ethylamphetamine) MDMA ("Ecstasy") ...... 200 ...... 250 ng/mL (3,4-Methylendioxymethamphetamine) MBDB ...... 200 ...... 250 ng/mL (N-Methyl-1-(3,4-Methylendiodyphenyl)-2-butanamine) Benzoylecgonine ...... 150 ...... 187.5 ng/mL Ecgoninmethylester ...... 150 ...... 187.5 ng/mL Morphine ...... 300 ...... 375 ng/mL Morphin-3--D-glucuronide ...... 300 ...... 375 ng/mL Codeine ...... 300 ...... 375 ng/mL Dihydrocodeine ...... 300 ...... 375 ng/mL 6-Monoacetylmorphine (6-MAM) ...... 10 ...... 12.5 ng/mL 7-Aminoflunitrazepam ...... 200 ...... 125 ng/mL Bromazepam ...... 100 ...... 125 ng/mL Oxazepam ...... 100 ...... 125 ng/mL Nordiazepam ...... 100 ...... 125 ng/mL Zolpidem ...... 100 ...... 125 ng/mL Secobarbital ...... 150 ...... 187:5 ng/mL THC COOH (11-Nor-9-THC carboxylic acid) .... 15 ...... 18:75 ng/mL Phencyclidine (PCP) ...... 25 ...... 31.25 ng/mL LSD (Lysergic acid diethylamide) ...... 1 ...... 1.25 ng/mL Methadone ...... 250 ...... 312:5 ng/mL EDDP ...... 250 ...... 312:5 ng/mL (2-Ethylen-1,5-dimethyl-3,3-diphenyl-pyrrolidine) Methaqualone ...... 300 ...... 375 ng/mL Propoxyphene...... 300 ...... 375 ng/mL Buprenorphine ...... 5 ...... 6.25 ng/mL Norbuprenorphine ...... 5 ...... 6.25 ng/mL

ME 40571 Drug U-confirmation, cut-off - 25 % drugs and medicaments urine confirmation control with 9 x 5 mL target values Lyophilised urine control (Medidrug U-Confirmation) prepared from human urine containing drugs and medicaments with target values. It is intended for the use as quality control to monitor the performance of urine toxicology confirmatory procedures by determination of drugs of abuse and drugs. Analyte cut off - 25% cut off Amphetamine...... 200 ...... 150 ng/mL d-Methamphetamine ...... 200 ...... 150 ng/mL MDA (3,4-Methylendioxyamphetamine) ...... 200 ...... 150 ng/mL MDEA ...... 200 ...... 150 ng/mL (3,4-Methylendioxy-N-ethylamphetamine) MDMA ("Ecstasy") ...... 200 ...... 150 ng/mL (3,4-Methylendioxymethamphetamine) MBDB ...... 200 ...... 150 ng/mL (N-Methyl-1-(3,4-Methylendiodyphenyl)-2-butanamine) Benzoylecgonine ...... 150 ...... 112.5 ng/mL Ecgoninmethylester ...... 150 ...... 112.5 ng/mL Morphine ...... 300 ...... 225 ng/mL Morphin-3--D-glucuronide ...... 300 ...... 225 ng/mL Codeine ...... 300 ...... 225 ng/mL Dihydrocodeine ...... 300 ...... 225 ng/mL 6-Monoacetylmorphine (6-MAM) ...... 10 ...... 7.5 ng/mL 7-Aminoflunitrazepam ...... 200 ...... 75 ng/mL Bromazepam ...... 100 ...... 75 ng/mL Oxazepam ...... 100 ...... 75 ng/mL Nordiazepam ...... 100 ...... 75 ng/mL Zolpidem ...... 100 ...... 75 ng/mL Secobarbital ...... 150 ...... 112.5 ng/mL THC-COOH (11-Nor-9-THC carboxylic acid) .... 15 ...... 11.25 ng/mL Phencyclidine (PCP) ...... 25 ...... 18.75 ng/mL LSD (Lysergic acid diethylamide) ...... 1 ...... 0.75 ng/mL Methadone ...... 250 ...... 187.5 ng/mL EDDP ...... 250 ...... 187.5 ng/mL (2-Ethylen-1,5-dimethyl-3,3-diphenyl-pyrrolidine) Methaqualone ...... 300 ...... 225 ng/mL Propoxyphene...... 300 ...... 225 ng/mL Buprenorphine ...... 5 ...... 3.75 ng/mL Norbuprenorphine ...... 5 ...... 3.75 ng/mL

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Matrix materials - drugs in blood, hair, serum, urine

Code Product Unit AC-UR015.050.003 Drugs and alcohol in urine, lyophilized (FDT -25%) 5 x 5 mL for in vitro diagnostic use This product is intended for use as a control material as part of laboratory’s internal quality assurance processes. Accuracy control for the internal quality assurance in the laboratory for forensic analytics and for the execution of alcohol and drug screenings within the framework of the MPU (German medical psycological assessment), by using the new generally valid evaluation criteria regarding the German driving aptitude test. The target values lie +/ – 25% above/below the defined cut-off-values of the Federal Highway Research Institute (BASt). The control material consists of urine on a human basis to which narcotics, drugs, and alcohol consumption markers have been added. Analytes target concentration Amphetamine ...... 37,5 μg/L Bromazepam ...... 37,5 μg/L d-Methamphetamine ...... 37,5 μg/L Nordiazepam ...... 37,5 μg/L MDMA 3,4-Methylenedioxymethamphetamine .. 37,5 μg/L Oxazepam ...... 37,5 μg/L MDA 3,4-Methylenedioxyamphetamine ...... 37,5 μg/L Zolpidem ...... 37,5 μg/L MD(E) A3,4-Methylenedioxyethylamphetamine . 37,5 μg/L Lorazepam ...... 37,5 μg/L Benzoylecgonine ...... 22,5 μg/L THC-COOH (11-nor-9-THC carbonic acid) ...... 7,5 μg/L Morphine ...... 18,75 μg/L Buprenorphine ...... 1,75 μg/L Codeine ...... 7,5 μg/L Norbuprenorphine ...... 1,75 μg/L Dihydrocodeine ...... 7,5 μg/L Methadone ...... 37,5 μg/L 6-MAM 6-Monoacetylmorphine ...... 3,75 μg/L EDDP ...... 37,5 μg/L 7-Aminoflunitrazepam ...... 37,5 μg/L 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine Alprazolam ...... 37,5 μg/L GHB gamma-Hydroxybutyric acid ...... 7500 μg/L Diazepam ...... 37,5 μg/L Ethylglucuronide ...... 75 μg/L Flunitrazepam ...... 37,5 μg/ Ethylsulfate...... 75 μg/L

AC-UR015.050.004 Drugs and alcohol in urine, lyophilized (FDT + 25%) 5 x 5 mL for in vitro diagnostic use This product is intended for use as a control material as part of laboratory’s internal quality assurance processes. Accuracy control for the internal quality assurance in the laboratory for forensic analytics and for the execution of alcohol and drug screenings within the framework of the MPU (German medical psycological assessment), by using the new generally valid evaluation criteria regarding the German driving aptitude test. The target values lie +/ – 25% above/below the defined cut-off-values of the Federal Highway Research Institute (BASt). The control material consists of urine on a human basis to which narcotics, drugs, and alcohol consumption markers have been added. Analytes target concentration Amphetamine ...... 62,5 μg/L Bromazepam ...... 62,5 μg/L d-Methamphetamine ...... 62,5 μg/L Nordiazepam ...... 62,5 μg/L MDMA 3,4-Methylenedioxymethamphetamine .. 62,5 μg/L Oxazepam ...... 62,5 μg/L MDA 3,4-Methylenedioxyamphetamine ...... 62,5 μg/L Zolpidem ...... 62,5 μg/L MD(E) A3,4-Methylenedioxyethylamphetamine . 62,5 μg/L Lorazepam ...... 62,5 μg/L Benzoylecgonine ...... 37,5 μg/L THC-COOH (11-nor-9-THC carbonic acid) .... 12,5 μg/L Morphine ...... 31,25 μg/L Buprenorphine ...... 2,25 μg/L Codeine ...... 12,5 μg/L Norbuprenorphine ...... 2,25 μg/L Dihydrocodeine ...... 12,5 μg/L Methadone ...... 62,5 μg/L 6-MAM 6-Monoacetylmorphine ...... 6,25 μg/L EDDP ...... 62,5 μg/L 7-Aminoflunitrazepam ...... 62,5 μg/L 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine Alprazolam ...... 62,5 μg/L GHB gamma-Hydroxybutyric acid ...... 12500 μg/L Diazepam ...... 62,5 μg/L Ethylglucuronide ...... 125 μg/L Flunitrazepam ...... 62,5 μg/L Ethylsulfate...... 125 μg/L

NIST-1511 Multi-drugs of abuse in freeze-dried urine 3 x 25 mL This material is intended primarily for verifying the accuracy of methods used for the determination of morphine, codeine, cocaine, (benzoylecgonine), and marijuana metabolite (THC-9-COOH) and phencyclidine in human urine. One set consists of three bottles of freeze-dried urine with all of the analytes included in each bottle. There is no blank urine with this set. Analytes Morphine ...... 309 20 ng/mL THC-9-COOH...... 14.1 0.8 ng/mL Codeine ...... 288 11 ng/mL Phencyclidine ...... 20.7 2.0 ng/mL Benzoylecgonine ...... 162 8 ng/mL

AC-WH015.015.001 Drugs of abuse in whole blood, lyophilized - BTMF 3/10-B WH 10 x 2.5 mL for in vitro diagnostic use This product is intended for use as a control material as part of a laboratory’s internal quality assurance processes. The control is prepared by spiking human whole blood with drugs of abuse. The concentrations of the drugs and metabolites lie within the expected treatment ranges. The target values were released by the coordinator of proficiency testing of the GTFCh

Analytes target values Amphetamine ...... 90,2 μg/L Methamphetamine ...... 103,1 μg/L MDMA ...... 54,6 μg/L MDA ...... 66,0 μg/L MD(E)A ...... 45,3 μg/L MBDB ...... 57,1 μg/L Cocaine ...... 47,9 μg/L Benzoylecgonine ...... 145,2 μg/L Ecgoninemethyl ester ...... 37,0 μg/L Codeine ...... 144,3 μg/L Morphine ...... 30,0 μg/L Dihydrocodeine ...... 147,9 μg/L μg/L delta 9 Tetrahydrocannabinol ...... 3,1 μg/L 11-OH- delta 9-Tetrahydrocannabinol ...... 2,6 μg/L 11-nor- delta 9-THC carbonic acid ...... 40,5 μg/L

194 Deuterated and native substances for TDM available on request! Edition 2011/2012

Sports drugs and steroids Reference materials for sports drugs analysis from NMIA

National Measurement Institute of Australia (NMIA) produces some 200 state-of-the-art certiﬁed reference materials for sports drugs applications.

• Synthetic steroids and their metabolites • Endogenous steroids and their metabolites • Prohormones and their metabolites • Growth promotants and their metabolites • Various other substances of interest

NMIA has a third party accreditation as a reference materials producer operating to ISO Guide 34. Its reference materials are supplied with a comprehensive analysis report that includes:

• Certiﬁed property values with uncertainty statements • Homogeneity and stability studies on all materials • Traceability of assigned values to the international system of units

www.lgcstandards.com Australian Government

National Measurement Institute Spectroscopic and other characterisation data ESI-MS: Instrument Micromass Quatro LC Micro REFERENCE MATERIAL ANALYSIS REPORT Operation: Negative ion mode, direct infusion at 10 L/min Ionisation: ESI spray voltage at 3.0 kV negative ion Report ID: S002.2011.02 EM voltage: 650 V Compound Name: 5 -Androstan-3 , 17 -diol-17 -glucuronide Cone voltage 20 V Description: White solid Peak: 467.3 (M-H+) m/z Collection No: S002 Batch No: 09-S-06 HS-GC-MS: Instrument: Agilent 6890/5973/G1888 Chemical Formula: C H O Molecular Weight: 468.6 25 40 8 Column: DB-624, 30 m x 0.25 mm I.D. x 1.4 m CAS No: 95237-44-8 Batch production completed: June 2011 Structure: Program: 50 C (5 min), 7 C/min to 120 C, 15 °C/min to 220 °C (8.3 min)

OH Injector: 150 C Transfer line temp: 280 C Carrier: Helium, 1.2 mL/min Split ratio: 50/1 O OH Solvents detected: No solvents detected. O TLC: Conditions: Kieselgel 60F . Chloroform/methanol (2/1). OH 254 Single spot observed, Rf = 0.8. Visualisation with vanillin. CO2H IR: Instrument: Biorad FTS300MX FT-IR HO Range: 4000-400cm-1, KBr powder H Peaks: 3406, 3319, 2914, 1728, 1448, 1354, 1253, 1165, 1059, 1031, 1003 cm-1 Synonyms: (3 5 , 17 )-Hydroxyandrostan-17yl--D-glucopyranosiduronic acid 1H NMR: Instrument: Bruker Avance DMX-600 3 -Hydroxy-5 -androstan-17-yl-glucosiduronic acid Field strength: 600 MHz Solvent: CD OD (3.31 ppm) 5 -Androstane-3 -ol-17 -O-glucuronide 3 Spectral data: 0.76 (1H, m), 0.82 (3H, s), 0.83 (3H, s), 0.90-1.02 (2H, m), 1.14-1.70 Androstane -D-glucopyranosiduronic acid derivative (17H, m), 1.96-2.02 (2H, m), 3.20 (1H, dd, J = 7.9, 9.2 Hz), 3.35 (1H, t, J = Purity (mass fraction): 88.1 ± 2.1 % (95 % coverage interval) 9.1 Hz), 3.51 (1H, t, J = 9.6 Hz), 3.67 (1H, t, J = 8.6 Hz), 3.73 (1H, d, J = 9.8 Hz), 3.95 (1H, m), 4.37 (1H, d, J = 7.8 Hz) ppm Purity estimate obtained from a combination of traditional analytical techniques and quantitative nuclear magnetic resonance (QNMR). The purity estimate by traditional analytical techniques was obtained by 13C NMR: Instrument: Bruker Avance DMX-600 subtraction from 100 % of total impurities by HPLC with ELS detection, thermogravimetric analysis, Karl Field strength: 150 MHz Solvent: d6-DMSO (39.5 ppm) 1 Fischer analysis and H NMR. The purity estimate by QNMR was obtained using a certified internal standard Spectral data: 11.1, 11.4, 19.9, 22.8, 28.2, 28.5, 28.6, 31.4, 32.0, 34.9, 35.7, 35.8, 36.9, of maleic acid. Supporting evidence is provided by headspace GC-MS analysis of occluded solvent and 38.6, 42.7, 50.4, 54.1, 64.1, 71.5, 73.4, 75.7, 76.1, 87.7, 103.5, 170.4 ppm elemental microanalysis. Melting point: 256-257 °C Warning: This material has shown signs of long term instability in methanol solution. While not confirmed, we believe this to be the result of esterification to the methyl ester. Microanalysis: Found: C = 57.0 %; H = 9.0 % HPLC: Column: Symmetry C18, 5 m (4.6 mm 150 mm) Calc: C = 64.1 %; H = 8.6 % (Calculated for C25H40O8) Mobile Phase: Methanol/water with formic acid pH 2.3 (70:30) Calc: C = 57.1 %; H = 8.9 % (Calculated for C25H40O8 + 11.0 % H2O) Flow Rate: 1.0 mL/min Column oven: 40 °C Detector: ELSD Retention time: 5.4 min. Relative peak area response of main component: Initial analysis: Mean = 99.6%, s= 0.1 (7 sub samples in duplicate, June 2011) Karl Fischer analysis: Moisture content 11.5% mass fraction (June 2011) QNMR: Instrument: Bruker Avance DMX-600 Field strength: 600 MHz Solvent: CD3OD Internal standard: Maleic acid (98.7% m/m) Initial analysis: Mean (4.4 ppm) = 88.1%, s = 0.9% (6 sub samples in duplicate, June 2011) Initial analysis: Mean (4.0 ppm) = 88.1%, s = 1.0% (6 sub samples in duplicate, June 2011)

Expiration of certification The property values are valid till 28th June 2014, i.e. three years from the date of certification provided the unopened material is handled and stored in accordance with the recommendations below. The material as issued in the unopened container and stored as recommended below should be suitable for use beyond this date, subject to confirmation of batch stability from the issuing body. The expiry date/shelf life does not apply to sample bottles that have been opened. In such cases, it is recommended that the end-user conduct their own in-house stability trials. The long-term stability of the compound in solution has not been examined. This material has been given a shelf life of three years from the date of certification. The material will be re- tested on an annual basis to ensure that the property values are still valid. In the event a product fails the stability trial, notification will be sent to all impacted customers. In the absence of stability data the measurement uncertainty at the 95% confidence interval has been expanded to accommodate any potential change in the property value. The stability component has been estimated from stability trials conducted on similar materials by NMI Australia over the last 10 years. Homogeneity assessment The homogeneity of the material was assessed using purity assay by HPLC with ELS detection on seven randomly selected 1-2 mg sub samples of the material. The material was judged to be homogeneous at this level of sampling as the variation in analysis results between samples was not significantly different at a 95% confidence level from that observed on repeat analysis of the same sample. Recommended storage When not in use, this material should be stored at or below 4 ºC in a closed container in a dry, dark area. Intended Use For in vitro laboratory analysis only. Caution Treat as hazardous substance. Use appropriate work practices when handling to avoid skin or eye contact, ingestion or inhalation of dust. Legal notice Neither NMI nor any person acting on NMI’s behalf assumes any liability with respect to the use of, or for damages resulting from the use of, this reference material or the information contained in this certificate.

Authorised by:

Dr Stephen R. Davies, Team Leader, Chemical Reference Materials, NMI. Dated: 3 August, 2011.

Characterisation data and property values specified in this report were first issued on 1st August 2011.

1 Suakin Street Pymble, NSW 2073 PO Box 385 Pymble NSW 2073 Tel: +61 2 9449 0111 Fax: +61 2 9449 1653 www.measurement.gov.au ABN: 74 599 608 295 ______National Measurement Institute Page 3 of 3 Sports drugs and steroids Sports drugs and steroids Ordering of certified reference materials for sports drugs analysis Because of its partnership, as a government laboratory, with the regulatory bodies (e.g. WADA - World Anti Doping Agency) controlling the use of performance-enhancing materials in sport, NMIA places restrictions on the distribution of all its sports drugs. Your local LGC Standards office will provide information about the rules and regulations for sports drugs pertaining to your country, and assist you throughout the ordering process.

Anabolic steroid reference materials 1-Androstendione

Code Product Unit NMIAD845 1-Androstendione (5alpha-Androst-1-en-3,17-dione) ° (for WADA labs, O 1 mg only)

O H CERA-084 Androstene-3,17-dione-2,3,4-13C3 (0.1 mg/ml) 1 mL in Acetonitrile

Aromatase inhibitors NMIAD909 Bis-(4-cyanophenyl)methanol (Letrazole metabolite) ° OH 1 mg

NC CN Selective estrogen receptor modulators (SERMs) Bolasterone metabolites

NMIAD614 7alpha,17alpha-Dimethyl-5beta-androstane-3alpha,17beta-diol ° OH 1 mg

O Cl OH NMIAD628 7alpha,17alpha-Dimethyl-5beta-androstane-3alpha,17beta-diol OH 1 mg glucuronide °

NaO C 2 O HO HO O H OH Boldenone and metabolites NMIAD564 5beta-Androst-1-en-17beta-ol-3-one ° OH 1 mg

O H NMIAD935 5beta-Androst-1-en-17beta-ol-3-one glucuronide, free acid ° 1 mg NMIAD582 17alpha-Boldenone (Epiboldenone) ° OH 1 mg

O NMIAD581 17beta-Boldenone-D3 ° 1 mg

HO NMIAD862 17-beta-Boldenone glucuronide potassium salt ° OH 1 mg HO CO2K O O

O NMIAD931 17beta-Boldenone sulfate (triethylamine salt) 5 mg

NMIAD811 17beta-Boldenone sulfate-D3 ° OSO3Na 1 mg D D D

198 Further steroids available on request! Edition 2011/2012

Sports drugs and steroids

Code Product Unit Calusterone and metabolites NMIAD618 Calusterone ° OH 1 mg

O NMIAD624 7beta,17alpha-Dimethyl-5beta-androstane-3alpha,17beta-diol ° OH 1 mg

HO H NMIAD629 7beta,17alpha-Dimethyl-5beta-androstane- OH 1 mg 3alpha,17beta-diol glucuronide °

NaO C 2 O HO HO O H OH Catecholamines CERC-109 Catecholamine Mix 1 (Epinephrines) (1.0 mg/ml) 1 mL in Methanol CERC-110 Catecholamine Mix 2 (Metanephrines) ( 1.0 mg/mL)(as free base) of each component 1 mL in Methanol CERC-111 Catecholamine Metabolites Mix(1.0 mg/ml) of each component 1 mL in Methanol CERH-091 (±)-4-Hydroxy-3-methoxymandelic Acid-D3 (ring-D3) (VMA-D3) (0.1 mg/ml) 1 mL in Methanol

CERH-092 4-Hydroxy-3-methoxyphenyl-D3-acetic-D2 Acid (HVA-D5) (0.1 mg/ml) 1 mL in Methanol

CERM-148 (±)-Metanephrine-D3 HCl (0.1 mg/ml) (as free base) 1 mL in Methanol

CERN-068 (±)-Normetanephrine-D3 HCl(0.1 mg/ml) (as free base) 1 mL in Methanol

Clostebol metabolite

NMIAD563 4-Chloro-4-androsten-3alpha-ol-17-one ° O 1 mg

HO Cl Danazol metabolite NMIAD920 2alpha-Hydroxymethylethisterone ° OH 1 mg OH

O Drostanolone metabolites NMIAD567 2alpha-Methyl-5alpha-androstan-3alpha-ol-17-one ° O 1 mg

HO H NMIAD601 2alpha-Methyl-5alpha-androstan-3alpha-ol-17-one O 1 mg glucuronide °

NaO C 2 O HO HO O H OH Endogenous steroids CERC-106 Cortisol (1.0 mg/ml) in Methanol 1 mL CERD-061 11-Deoxycortisol (1.0 mg/ml) in Methanol 1 mL

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Sports drugs and steroids

Code Product Unit CERD-062 21-Deoxycortisol (0.1 mg/ml) in Methanol 1 mL CERE-074 Estriol (1.0 mg/ml) 1 mL in Methanol

CERE-075 Estrone (1.0 mg/ml) 1 mL in Methanol

Estrogen antagonist

O NMIAD921 3-Hydroxy-4-methoxytamoxifen N 1 mg

O OH Finasteride metabolite O H NMIAD910 Carboxy finasteride N 1 mg CO H H 2

O N H Fluoxymesterone and metabolites

CERF-909 Fluoxymesterone (1.0 mg/mL) H3C OH 1 mL in Dimethoxyethane HO H3C F CH3

NMIAD571 9alpha-Fluoro-17,17-dimethyl-18-nor-androstan-4,13-diene-11beta- HO 1 mg ol-3-one °

F O OH NMIAD616 9alpha-Fluoro-17alpha-methyl-4-androsten-3alpha, 6beta,11beta, HO 1 mg 17beta-tetra-ol °

F HO OH NMIAD617 6beta-Hydroxyfluoxymesterone ° OH 1 mg HO

F O OH Formebolone metabolite NMIAD622 2-Hydroxymethyl-17alpha-methylandrostadiene-11alpha,17beta-diol- OH 1 mg HO 3-one ° HO

O Furazabol metabolite NMIAD602 16beta-Hydroxyfurazabol ° OH 1 mg

OH N O N H Growth promotants and metabolites NMIAM954 Clenbuterol-D9 HCl Cl 1 mg H2N D3C CD3 Cl N CD H 3 OH .HCl

200 Further steroids available on request! Edition 2011/2012

Sports drugs and steroids

Code Product Unit

NMIAP1787 Zearalenone OH O CH3 10 mg O

HO O 13 ® B-MYC0610-1.2 Zearalenone (U- C18) 25 μg/mL in Acetonitrile CERTAN 1.2 mL NMIAP1801 alpha-Zearalanol OHO CH3 5 mg O

HO OH NMIAP1795 alpha-Zearalenol OHO CH3 5 mg O

HO OH NMIAP1802 beta-Zearalanol OHO CH3 5 mg O

HO OH

NMIAP1796 beta-Zearalenol OH O CH3 5 mg O

HO OH CERC-081 Clenbuterol-D9 HCl (0.1 mg/ml) as free base 1 mL in Methanol Aromatase inhibitors NMIAD909 Bis-(4-cyanophenyl)methanol (Letrazole metabolite) ° OH 1 mg

NC CN Hydroxysteroids NMIAD852 4-Hydroxyandrostendione (Formestane) ° O 1 mg

O OH NMIAD853 4-Hydroxynandrolone (Oxabolone) ° OH 1 mg H

O OH NMIAD851 4-Hydroxytestosterone ° OH 1 mg

O OH CERH-059 OH 1 mL 6beta-Hydroxytestosterone (0.1 mg/mL) CH3 in Methanol CH3

O OH

OH CERT-034 6beta-Hydroxytestosterone-D3 (0.1 mg/ml) CH3 1 mL in Methanol D D CH3 D

OH Mesterolone metabolites NMIAD556 1alpha-Methyl-5alpha-androstan-3alpha,17beta-diol ° OH 1 mg

HO H NMIAD599 1alpha-Methyl-5alpha-androstan-3alpha,17beta-diol OH 1 mg glucuronide °

HO2C O (+ 2.5 H2O) HO HO O H OH

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Code Product Unit NMIAD557 1alpha-Methyl-5alpha-androstan-3alpha-ol-17-one ° O 1 mg

HO H NMIAD598 1alpha-Methyl-5alpha-androstan-3alpha-ol-17-one O 1 mg glucuronide °

NaO C 2 O HO ( + 2.5 H2O) HO O H OH Methenolone and metabolites

CERM-910 Methenolone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane H3C CH3

O H

NMIAD619 1-Methylene-5alpha-androstan-3alpha-ol-17-one ° O 1 mg

HO H NMIAD597 1-Methylene-5alpha-androstan-3alpha-ol-17-one O 1 mg glucuronide °

NaO C 2 O ( + 2 H O) HO 2 HO O H OH Methandienone and metabolites NMIAD639 17,17-Dimethyl-18-nor-5beta-androsta-1,13-diene-3alpha-ol ° 1 mg

HO H NMIAD576 17,17-Dimethyl-18-norandrosta-1,4,13-trien-3-one ° 5 mg

O NMIAD638 Epimetendiol ° 1 mg OH

HO H

NMIAD562 17-Epimethandienone ° CH3 1 mg OH

O NMIAD565 6beta-Hydroxymethandienone ° OH 1 mg

O OH NMIAD630 Methandienone ° OH 10 mg

CERM-912 Methandienone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CH3 H3C

202 Further steroids available on request! Edition 2011/2012

Sports drugs and steroids

Code Product Unit Methyldienolone NMIAD916 Methyldienolone ° OH 1 mg

O Methyltestosterone and metabolites

CERM-906 17a-Methyltestosterone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CH3 H3C

CERM-914 17a-Methyl-5a-androstane-3a,17ß-diol (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CH3 H3C

HO H

CERM-916 17a-Methyl-5b-androstane-3a,17ß-diol (1.0 mg/ml) H3C OH 1 mL in 1,2-Dimethoxyethane CH3 H3C

HO H NMIAD560 17alpha-Methyl-5alpha-androstane-3alpha,17beta-diol ° OH 1 mg CH3

HO H NMIAD561 17alpha-Methyl-5beta-androstane-3alpha,17beta-diol ° OH 1 mg CH3

HO H NMIAD928 17alpha-Methyl-5beta-androstan-3alpha-17beta-diol-D3 ° OH 1 mg CD3

HO H 17alpha-Methyl-1-testosterore NMIAD904 17beta-Hydroxy-17alpha-methyl-5alpha-androst-1-ene-3-one OH 1 mg

O H Nandrolone and metabolites NMIAD722 17alpha-Nandrolone (Epinandrolone) ° OH 1 mg

NMIAD783 17alpha-Nandrolone (Epi-nandrolone) sulfate ° OSO3HNEt3 5 mg

O NMIAD583 17beta-Nandrolone-D3 ° OH 5 mg D H D D

O NMIAD679 17beta-Nandrolone-13C2 ° CH3 OH 5 mg

13C 13 O C

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Code Product Unit NMIAD684 17beta-Nandrolone decanoate ° O 10 mg

CH3 O (CH2)8CH3 H

O NMIAD861 17-beta-Nandrolone glucuronide potassium salt ° O 1 mg CH3 O (CH

NMIAD809 17beta-Nandrolone sulfate (Na+ salt) OSO3 1 mg Na H

NMIAD782 17beta-Nandrolone sulfate-D3 (TEA Salt) ° OSO3HNEt3 1 mg D H D D

O NMIAD555 19-Norandrosterone ° O 1 mg H

HO H

CERE-910 5a-Estran-3a-ol-17-one (Norandrosterone) (1.0 mg/mL) H3C O 1 mL in 1,2-Dimethoxyethane

HO H

O NMIAD584A 19-Norandrosterone-D4 ° CH3 1 mg

H D D

HO D D H NMIAD596a 19-Norandrosterone glucuronide ° O 1 mg H

NaO C 2 O HO HO O H OH NMIAD898 19-Norandrosterone glucuronide-D4 (Na+ salt) ° O 1 mg

D H D NaO2C O HO O HO H OH D D NMIAD841 19-Norandrosterone sulfate ° (for WADA labs, only) O 2 mg

H O Et3NH O S O O H O NMIAD554 19-Noretiocholanolone ° CH3 1 mg H

HO H

CERE-908 5ß-Estran-3a-ol-17-one (Noretiocholanolone) (1.0 mg/mL) H3C O 1 mL in 1,2-Dimethoxyethane

HO H

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Code Product Unit

CERE-911 5ß-Estran-3a-ol-17-one-D3 (Noretiocholanolone) (100 μg/mL) H3C O 1 mL in 1,2-Dimethoxyethane

HO D D D NMIAD926 5(10)-Estrene-3beta,17alfa-diol 1 mg NMIAD742 19-Noretiocholanolone-D4 ° O 1 mg H D D

HO D D H NMIAD595a 19-Noretiocholanolone glucuronide ° O 1 mg

NaO C 2 O HO HO O H OH Norbolethone and metabolites NMIAD825 Norbolethone (13beta,17alpha-Diethyl-gonan-4-ene-17beta-ol-3-one) ° 1 mg NMIAD820 13beta,17alpha-Diethyl-5alpha-gonane-3alpha, 17beta-diol (minor OH 1 mg metabolite) ° H

HO H NMIAD818 13beta,17alpha-Diethyl-5beta-gonane-3alpha, 17beta-diol (major OH 1 mg metabolite) ° H

HO H Norethandrolone and metabolites

CERN-914 Norethandrolone (1.0 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CH2CH3 H

O NMIAD558 17alpha-Ethyl-5alpha-estrane-3alpha,17beta-diol ° OH 1 mg CH2CH3 H

HO H NMIAD559 17alpha-Ethyl-5beta-estrane-3alpha,17beta-diol ° OH 1 mg CH2CH3 H

HO H

CERE-905 17a-Ethyl-5ß-estrane-3a-17b-diol (100 μg/mL) H3C OH 1 mL CH CH in 1,2-Dimethoxyethane 2 3

HO H Oral turinabol and metabolites (dehydrochloromethyltestosterone) NMIAD615 6beta-Hydroxy-oral turinabol ° OH 1 mg

O Cl OH NMIAD613 Oral turinabol ° OH 1 mg

O Cl

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Code Product Unit Oxandrolone metabolite

NMIAD620 17-Epioxandrolone ° OH 1 mg

O H Prohormones and metabolites NMIAD878 1,4-Androstadiene-3,17-dione (Boldendione) O 1 mg

O NMIAM955 Androstendione ° O 10 mg

O NMIAD645 19-Androstendione-D3 ° O 1 mg

CD3

O NMIAD796 Dehydroepiandrosterone (DHEA) ° O 10 mg

HO CERD-063 Dehydroepiandrosterone (DHEA) (1.0 mg/ml) in Methanol 1 mL CERD-064 DHEA-D5 (Dehydroepiandrosterone-2,2,3,4,4-D5) (0.1 mg/ml) 1 mL CERD-065 Dehydroepiandrosterone 3-sulfate sodium salt (DHEAS) (as free sulfate) (1.0 mg/ml) in 1 mL Methanol CERD-066 Dehydroepiandrosterone-D5-3-sulfate sodium salt (DHEAS-D5) (2,2,3,4,4-D5) (O.1 mg/ml) 1 mL in Methanol NMIAD721 19-Norandrostendione (Estrendione) ° O 10 mg H

O PDE-5 Inhibitors NMIAD941 Tadalafil O 20 mg N

N N H O

O O Selective estrogen receptor modulators (SERMs)

O NMIAD921 3-Hydroxy-4-methoxytamoxifen N 1 mg

O OH Anti-estrogenic substances (others) NMIAD930 4-Hydroxycyclofenil OH 1 mg

HO OH Stanozolol and metabolites NMIAD577 3'Hydroxystanozolol ° OH 1 mg

N N H H

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Code Product Unit

CERS-903 3'-Hydroxystanozolol-D3 (0.1 mg/mL) H3C OH 1 mL in 1,2-Dimethoxyethane CD3 OH H3C

N N H H

NMIAD642 4alpha-Hydroxystanozolol ° OH 1 mg

N N H O H H NMIAD641 4beta-Hydroxystanozolol ° OH 0.5 mg

N N H O H

H NMIAD621 16beta-Hydroxystanozolol ° (for qualitative analysis, only) OH 1 mg OH

N N H H

OH CERH-915 16ß-Hydroxystanozolol (100 μg/mL) H3C 1 mL CH3 OH in 1,2-Dimethoxyethane H3C

N N H H

NMIAD640 3'-Hydroxystanozolol glucuronide ° OH 1 mg HO2C O HO O HO OH N N H H NMIAD646 Stanozolol ° OH 10 mg

N N H H

H C CERS-906 Stanozolol (1.0 mg/ml) 3 OH 1 mL CH3 in 1,2-Dimethoxyethane H3C

H Stimulants NMIAD891 Carphedrone ° O 10 mg

NH2 N O

NMIAD914 Cyclazadone O 10 mg

N O HN NMIAD893 Famprofazone 20 mg

N N N O

NMIAD915 Fenbutrazate HCl 1 mg O O

N N HCl HCl O O

O O

NMIAD913 Fencamine O 10 mg N N N N N N O H

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Code Product Unit

NMIAD543 Fenetylline HCl CH3 20 mg O N H H3C N N .HCl

O N N

CH3

H HCl NMIAD500 Fenproporex HCl N 50 mg C N

NMIAM299 Heptaminol HCl ° HCl 50 mg H2N

OH OH OH NMIAD940 Isometheptene mucate NHMe CO2H 20 mg HO2C OH OH 2

H NMIAD283 Mefenorex HCl N Cl 50 mg

CH3 HCl

NMIAD895 (±)-4-Methylamphetamine HCl CH3 10 mg

NH2 . HCl H3C NMIAM296 Norephedrine HCl (Phenylpropanolamine) - DRUG PRECURSOR HO 100 mg HCl

NH2 NMIAM297 (+)-Norpseudoephedrine HCl (Cathine) OH 50 mg NH2 HCl NMIAD912 Ortetamine HCl (1-(2-methylphenyl)-2-propylamine HCl) 10 mg CH3

NH2 .HCl OH NMIAD892 Oxilofrine HCl H HCl 5 mg N

HO OH NMIAM898 Salbutamol H 10 mg N HO

OH NMIAD939 Salbutamol-D3 DD H 1 mg N HO D HO

OH O OH H N NMIAM904 Salmeterol hydroxynaphthoate HO HO 50 mg

HO O

NMIAD822 Selegiline HCl CH3 50 mg N .HCl H3C Suppressor of estrogen biosynthesis NMIAD909 Bis-(4-cyanophenyl)methanol (Letrazole metabolite) ° OH 1 mg

NC CN 1-Testosterone NMIAD871 5alpha-Androst-1-ene-3beta-17beta-diol ° OH 1 mg

HO H NMIAD767 1-Testosterone (5alpha-Androst-1-en-3-one-17beta-ol) ° OH 1 mg

O H Tetrahydrogestrinone and precursors NMIAD860 Gestrinone ° H3C OH 10 mg

O NMIAD872 Tetrahydrogestrinone (THG) ° OH 1 mg (for use in qualitative analysis only)

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Code Product Unit Trenbolone metabolite NMIAD708 17alpha-Trenbolone (Epitrenbolone) ° OH 5 mg

O Testosterone and metabolites NMIAD634 5alpha-Androstane-3alpha,17beta-diol ° OH 1 mg

HO H OH NMIAD593 5alpha-Androstane-3alpha,17beta-diol-D3 ° D 1 mg D D

HO H NMIAD635 5alpha-Androstane-3beta,17beta-diol ° OH 1 mg

HO H OH NMIAD594 5alpha-Androstane-3beta,17beta-diol-D3 ° D 1 mg D D

HO H NMIAD678 5alpha-Androstane-3beta,17beta-diol-3-glucuronide ° OH 1 mg

HOOC HO O HO O HO H NMIAD636 5beta-Androstane-3alpha,17beta-diol OH 1 mg

HO H NMIAD580 5beta-Androstane-3alpha,17beta-diol-D5 ° OH 1 mg

D D D HO D D H NMIAD637 5beta-Androstane-3beta,17beta-diol ° OH 1 mg

HO H OH NMIAD626 5beta-Androstane-3beta,17beta-diol-D3 ° D 1 mg D D

HO H NMIAD550 Androsterone ° O 10 mg

HO H NMIAD549 Androsterone-D4° O 1 mg

D D

HO D D H NMIAD572 Androsterone glucuronide ° O 1 mg

HO2C HO O O OH H HO

O NMIAD829 D4-Androsterone-beta-glucuronide (free acid) CO 2H 1 mg HO D O D

HO O H D H OH D NMIAD610 Androsterone sulfate (Na+ salt) ° O 1 mg

O O H S - Na + O O

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Code Product Unit NMIAD587 Androsterone sulfate-D4 ° O 1 mg

D D

Et3NH O3SO D D H CERD-073 5a-Dihydrotestosterone (DHT) (1.0 mg/ml) 1 mL in Methanol

NMIAD680 5alpha-Dihydrotestosterone ° OH 10 mg

O H NMIAD552 5alpha-Dihydrotestosterone-D3° OH 1 mg D D D

O H NMIAD574 5alpha-Dihydrotestosterone glucuronide ° OH 1 mg D D D

O H

OH HO NMIAD573 D3-5alpha-Dihydrotestosterone-beta-glucuronide (free acid) OH 1 mg O O CO2H

D D D

O H

NMIAD609 5alpha-Dihydrotestosterone sulfate ° OSO3.HNEt3 1 mg

O H NMIAD590 5alpha-Dihydrotestosterone sulfate-D3 ° OSO3.HNEt3 1 mg D D D

O H NMIAD547 Epitestosterone ° OH 1 mg

O D NMIAD548 Epitestosterone-D3 ° OH 1 mg D D

O NMIAD603 Epitestosterone glucuronide ° OH 1 mg HO OH O O CO2H

OH HO NMIAD604 Epitestosterone glucuronide-D3 ° D OH 1 mg O O CO 2K

NMIAD605 Epitestosterone sulfate ° OSO3. HNEt3 1 mg

O NMIAD591 Epitestosterone sulfate-D3 ° D 1 mg OSO3HNEt3 D D

O NMIAD551 Etiocholanolone ° 1 mg

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Code Product Unit NMIAD528 Etiocholanolone-D5 ° O 1 mg

D D HO D D D H NMIAD607 Etiocholanolone glucuronide ° O 1 mg

NaO C 2 O HO HO O H OH NMIAD608 Etiocholanolone sulfate ° O 1 mg

Et3NHO3SO H NMIAD606 Etiocholanolone sulfate-D5 ° O 1 mg

D D

Et3NHO3SO D D D H TRC-M342000 Mibolerone 10 mg NMIAM914 Testosterone OH 10 mg

OH CERT-037 Testosterone (1.0 mg/mL) CH3 1 mL in Acetonitrile CH3

O CERT-070 Testosterone-2,3,4-13C3 (0.1 mg/mL) 1 mL in Acetonitrile

OH NMIAD546 16,16,17-Testosterone-D3 ° D 1 mg D D

O NMIAD644 19-Testosterone-D3 ° OH 1 mg

CD3

O NMIAD683 Testosterone decanoate ° OH 10 mg

CD3

O NMIAD507 Testosterone glucuronide ° 1 mg NMIAD505 16,16,17-Testosterone glucuronide-D3 ° 1 mg NMIAD688 Testosterone isocaproate (4-methylpentanoate) ° O 10 mg O

NMIAD508 Testosterone sulfate ° OSO3. HNEt3 1 mg

OSO3HNEt3 NMIAD506 16,16,17-Testosterone sulfate-D3 ° D 1 mg D D

O Others CERM-080 Methylmalonic acid (1.0 mg/ml) 1 mL in Acetonitrile

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Code Product Unit Commercial materials (not certified by NMIA) NMIAM558 Bupranolol HCl 20 mg

NMIAD529 Dextromoramide tartrate 50 mg NMIAM642 Dipipanone HCl 20 mg

OH NMIAM880 Etilephrine HCl H 50 mg HO N CH3

H NMIAM394 Propylhexedrine N 50 mg CH3

CH3

NMIAM647 Terbutaline sulfate OH 20 mg H2 HO N C(CH3)3 2- SO4

2 OH

NMIAM605 Trimeperidine HCl N .HCl 20 mg

O Steroid matrix reference material NMIAMX002 19-Norandrosterone in Freeze Dried Human Urine (2.13 ng/g) Amp. (for WADA labs, only) NMIAMX003 19-Norandrosterone in 1,2-dimethoxyethane (221.4 ng/g) Amp. (for WADA labs, only) NMIAMX005 Testosterone Metabolites in Freeze Dried Human Urine: Bottle Testosterone glucuronide (39.9 ng/g) Epitestosterone glucuronide (10.66 ng/g) (for WADA labs, only) NMIAMX006 Testosterone (2.55 μg/g) and Epitestosterone (0,626 μg/g) Amp. in Methanol (for WADA labs, only)

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WADA funded sports drug testing materials

WADA funded sports drug testing materials The production of these materials is funded by the World Anti-Doping Agency. The products are restricted for issue to laboratories with WADA / IOC accreditation, only.

1-Androstendione

Code Product Unit NMIAD845 1-Androstendione (5alpha-Androst-1-en-3,17-dione) ° (for WADA labs, O 1 mg only)

O H Nandrolone metabolites NMIAD849 19-Noretiocholanolone sulfate ° (for WADA labs, only) O 1 mg H

NaO3SO H 1-Testosterone NMIAD832 5alpha-Androst-1-ene-3alpha-ol-17one (for WADA labs, only) O 0.2 mg

HO H Prohormones and metabolites NMIAD843 16alpha-Hydroxyandrosterone ° (for WADA labs, only) O 1 mg

HO OH NMIAD886 6beta-Hydroxyandrosterone ° (for WADA labs, only) O 1 mg

HO H OH NMIAD834 4beta-Hydroxy DHEA ° (for WADA labs, only) O 1 mg

HO OH NMIAD875 7alpha-Hydroxy DHEA ° (for WADA labs, only) O 1 mg

HO OH NMIAD865 7beta-Hydroxy DHEA ° (for WADA labs, only) O 1 mg

HO OH NMIAD844 16beta-Hydroxy DHEA ° (for WADA labs, only) O 1 mg

HO NMIAD833 7-Keto DHEA ° (for WADA labs, only) O 10 mg

HO O

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Code Product Unit NMIAD873 3alpha-Hydroxy-4-estren-17-one ° (for WADA labs, only) O 1 mg

HO NMIAD866 3beta-Hydroxy-4-estren-17-one ° (for WADA labs, only) O 1 mg

HO NMIAD867 6beta-Hydroxyetiocholanolone ° (for WADA labs, only) O 1 mg

HO H OH

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Higher-order reference materials

LGC Standards offers a range of certified reference materials (CRMs) to assist, e.g. manufacturers complying with the European in vitro diagnostics Directive 98/79/EC.

About higher-order reference materials • Produced by metrological institutes and organisations • Thoroughly characterised • Results linked to high-level interlaboratory comparisons • Smallest attainable uncertainties • Accompanied by a detailed certificate of analysis • Over 200 CRMs available.

Analyte categories: • Blood gases and groupings • Coagulation factors • Drugs • Enzymes • Metabolites and substrates • Non-electrolyte metals • Proteins and nucleic acids • ...and many more

Proficiency testing schemes

Controlled drug proficiency testing schemes from the National Measurement Institute of Australia (NMIA)

The NMIA runs an accredited program of regular proficiency tests that includes the controlled drugs heroin, cocaine, amphetamines and amphetamine type substances (MDA, MDMA, MDEA). Three rounds/year are organised, each focusing on a single drug. Participants are informed of the identity of the drug and so the PT schemes focus on quantitation. A round includes 2 to 4 test samples consisting of 100 to 150 mg of powder. Samples are prepared from seizures of controlled drugs and typically contain between 10 and 80 % drug as the base. Samples will only be sent to laboratories authorised to hold controlled drugs. Every year the following rounds are planned:

March/April: Heroin August: Cocaine November: Amphetamine type substances

Performance assessment and reporting

Participants are instructed to perform the analysis using their routine procedures and report a single result for each sample, together with an associated uncertainty. In some cases the identity of any diluent may also be requested. Participants’ performance is assessed by comparing reported test results to the assigned value using both z-scores and En-scores. Evaluation is based on procedures described in the IUPAC International Harmonized Protocol for Proficiency Testing of (Chemical) Analytical Laboratories, ISO/IEC Guide 43 and ISO 13528. To provide each participant with an early indication of performance, an interim report (distributed by e-mail as a PDF file) is issued within five working days of the due date for submission of results. A detailed final report is issued within eight weeks of the closing date for submission of results. Hard copy reports are posted to participants. The final reports are public documents and are published on the www.measurement.gov.au.

Confidentiality

The identity of participants is protected by means of a laboratory code, which is randomly assigned when a laboratory enrols in a PT round. These codes are confidential and are not disclosed to other persons.

Further information is available at www.measurement.gov.au (look for Interlaboratory Chemical Proficiency Testing Program under Products and services).

Edition 2011/2012 LGC Standards – Excellence through measurement 217

LGC Standards Aim of proficiency testing Promoting excellence through Proficiency testing is defined in ISO/IEC 17043 proficiency testing as the evaluation of participant performance LGC Standards is an accredited international against pre-established criteria by means of provider of proficiency testing (PT) services interlaboratory comparisons. The terms “External also known as External Quality Assessment Quality Assessment or EQA” are often used for (EQA). We have over twenty five years proficiency testing in the medical/clinical area. experience in all aspects of providing PT services LGC Standards Proficiency Testing provides to laboratories undertaking clinical, chemical, a wide range of schemes designed to improve microbiological, and physical measurements. the quality of analysis in those sectors covered. LGC Standards operates 39 proficiency testing The schemes involve the regular distribution schemes serving more than 7,000 laboratories. of test materials in order for participants to We produce in excess of 100,000 test materials test for defined parameters, and to have their which are distributed to over 140 countries results statistically analysed. Participation pro- worldwide. vides laboratories with a means of assessing the accuracy and comparability of their results We offer an unprecedented breadth of clinical, with peer laboratories over time. chemical, microbiological and physical testing schemes across a wide range of industries When performed within the context of a com- including clinical and forensic, pharmaceutical prehensive quality assurance programme, and phytochemical sectors, meat, dairy and other proficiency testing is an independent means food sectors, water, soil and other environmental of assuring the quality of test and calibration sectors, brewing, distilling, malting, sugar and results, as described in ISO/IEC 17025 and other beverage sectors, cosmetics, toys and ISO 15189. other consumer safety sectors. Quality standards In addition to the variety of schemes offered, LGC Standards Proficiency Testing is committed LGC Standards can also provide managed to continual improvement in quality and solutions for in-house proficiency testing providers efficiency through procedures based upon and training for participants and their customers. quality assurance. This commitment is demonstrated through certification to ISO 9001 for all its activities and accreditation to ISO/IEC 17043 for the operation, management and design of proficiency testing schemes. LGC Standards Proficiency Testing is accredited by the United Kingdom Accreditation Service (UKAS, certificate number: 0001). Clinical schemes are currently accredited to the UK Clinical Pathology Accreditation (CPA) guidelines reference number 028/0054, 0028/0055, 028/0060, 028/0315. A copy of our current scope of accreditation is available on our website: www.lgcpt.com Benefits of proficiency testing Who participates in LGC Standards proficiency testing schemes? Proficiency testing is an essential laboratory tool as it demonstrates a laboratory’s commitment LGC Standards exports to laboratories in over to good performance and enables participants 140 countries world-wide and our customer to confirm their ability to perform tests base ranges from single small enterprises competently; essential in the laboratory to inspection organisations of global repute. accreditation process. Our customers include hospitals and clinics, pharmaceuticals companies, government Participation in proficiency testing will: agencies, major international food manufacturers, • Enable participants to measure their research organisations, commercial and performance against others. contract laboratories. At present we have over • Give an early indication of potential problems 7,000 participants across the 39 schemes or training requirements. currently in operation. • Encourage good performance and reinforce LGC Standards manages a number of bespoke an interest in quality assurance. schemes for multi-national companies to meet • Demonstrate an ability to comply with their particular requirements. These special international regulations. schemes cover up to 200 laboratories. • Provide a valuable source of information. • Provide the means to measure consistency Why choose LGC Standards as your across a group of laboratories. proficiency testing provider?

Who should participate in proficiency • Access to a wide range of schemes from testing schemes? a single supplier. • Rapid turnaround of results. Anyone who needs to independently demonstrate • Access to expert support and advice. the quality of their analytical results should • Local representation and support. participate in PT/EQA schemes - because quality of results relates directly to quality of product, Why do I need proficiency testing? reputation in the market and, ultimately, brand Accreditation bodies strongly recommend value. Whether operating in the clinical, forensic, that laboratories participate in appropriate food, pharmaceutical, beverages, environmental PT schemes as they are the only quality tool monitoring or other sectors, many regulators which can assess the whole quality system. view PT schemes as an essential part of quality PT is a truly independent measure of laboratory monitoring and many laboratories link PT performance and anonymously compares results to key performance indicators in the performance with peer laboratories. It allows quality assurance process. the laboratory to compare and contrast the performance of analytical methods and can assist in the validation of new methods. Participation in a PT scheme is educational and can be used as a tool for staff training, allowing laboratories to learn from both positive and negative performance. PT/EQA schemes for clinical Benefits of participation in HEATHCONTROL and forensic toxicology PT/EQA schemes

LGC Standards, recently acquired Cardiff HEATHCONTROL is a respected name in the Bioanalytical Services Ltd and now operates field of EQA with over 450 participants in more the range of HEATHCONTROL (EQA) schemes than 36 countries. for laboratories and screening clinics covering: By participating in the HEATHCONTROL • Therapeutic Drug Monitoring (TDM). schemes each participant gains the benefits • Toxicology (TOX). of a global proficiency testing scheme: • Drugs of Abuse in Urine (DAU). • The schemes are a truly independent • Drugs in Oral Fluid (DOF). assessment of measurement quality, which The definitive aim of PT/EQA schemes in a enables laboratories to demonstrate their clinical setting is improvement in analytical competence and compliance with respect performance in support of improved patient care. to regulatory standards. • Performance assessments obtained in the schemes are recognised as a demonstration of laboratory quality by a range of ‘third parties’, such as, customers, regulators and accreditation bodies. • The comprehensive scheme reports provide invaluable feedback on laboratory performance and are widely used as a training tool for laboratory personnel. • Performance assessment by method provides a mechanism for laboratories to compare their measurements with others using similar techniques and assists in the evaluation and development of methods and instrumentation. • Wide variety of analytes from one supplier for all your needs. • Significant numbers of participants worldwide means statistically robust results. HEATHCONTROL – Therapeutic Drug There are many factors which influence an Monitoring (TDM) individual’s serum drug levels, these include but are not restricted to the age, sex, and weight The Therapeutic Drug Monitoring (TDM) of the patient; the route of administration of the scheme is designed to provide an independent drug; the drug’s absorption rate, excretion rate, performance assessment for laboratories delivery rate, and dosage; other medications the and clinics who are involved in the routine patient is taking; pregnancy, temporary illness, quantification of therapeutic drugs in serum. infection, emotional and physical stress, The TDM scheme is fully accredited in the U.K. trauma, and surgery; the patient’s compliance by Clinical Pathology Accreditation (CPA). regarding the drug treatment regimen; and the TDM is the measurement of specific drug levels laboratory methods used to measure the drug. (concentrations) at timed intervals in patients, Effective TDM follows these changes and usually through blood samples, and is necessary tailors the dosages to fit the current needs where control of drug concentrations is of the specific patient. required to achieve optimum treatment for Drug concentrations in serum or whole blood the patient. are only meaningful if the correct procedures For most drugs, monitoring is not required are followed regarding the timing of specimens. as they have a wide therapeutic index i.e. the Failure to meet these requirements accounts difference between a therapeutic and toxic for most errors in TDM. It is very important to concentration is large. Therefore, most individuals note the exact time the sample is taken and will be effectively treated without extreme side when each dose of the drug is given as it allows effects or symptoms of toxicity. for accurate interpretation of the measured levels and the patient’s response to their dosing However, drugs with a narrow therapeutic index regimen. may result in a high or low serum concentration if not monitored and controlled. Drug Although serum drug concentrations and the concentrations in the bloodstream that are too therapeutic interval are useful in evaluating drug high have the potential to exert adverse effects therapy, they should not be the only criteria on associated with toxic or even fatal consequences. which treatment is based. Therapeutic drug Drug concentrations below the therapeutic monitoring is a multidisciplinary function, requiring index can lead to poor response to treatment. collaboration between scientists, clinicians, For some drugs, maintaining this steady state nurses and pharmacists in order to ensure that is not as simple as giving a standard dose of best practice in TDM is achieved. The team medication. must remember to always treat the patient, not the level.

The full range and availability of test materials in TDM is determined on an annual basis and further details can be found in the TDM application form and scheme information document. Test material Analytes

Human serum: Caffeine, Carbamazepine, Therapeutic 15 analyte Carbamazepine 10, 11-epoxide, drug mixture Clonazepam, Digoxin, Ethosuximide, Gentamicin, Lamotrigine, Lithium, Phenobarbital, Phenytoin, Primidone, Theophyl- line, Valproate, Vancomycin.

Human serum: Clobazam / Norclobazam. Anti-epileptic drugs

Human serum: OH-oxcarbazepine, Gabapentin, Newer anti-epileptic drugs Levetiracetam, Pregabalin. AE1 mixture

Human serum: Felbamate, Lacosamide, Newer anti-epileptic drugs Ruﬁnamide, Tiagabine, Topiramate, AE2 mixture Vigabatrin, Zonisamide.

Human serum: Amiodarone, Desethylamiodarone, Cardiac drugs mixture Flecainide.

Newborn calf serum or Amitriptyline / nortriptyline, Human serum: Psychoactive drugs Clomipramine / norclomipramine, Clozapine / norclozapine, Imipramine / desipramine.

Amisulpride, Aripiprazole / dehydroaripiprazole, Citalopram / norcitalopram, Dosulepin(dothiepin) / northiaden, Doxepin / nordoxepin, Fluoxetine / norﬂuoxetine, Fluphenazine, Fluvoxamine, Haloperidol, Maprotiline / normaprotiline, Mirtazapine / normirtazapine, Olanzapine, Paroxetine, Perphenazine, Quetiapine, Risperidone / HO-risperidone,

Sertraline / norsertraline,

Thioridazine,

Trimipramine / nortrimipramine,

Venlafaxine / norvenlafaxine, Zuclopenthixol.

Human serum: Methotrexate. Anti-cancer drug

Human serum: Amikacin, Chloramphenicol, Antibiotic drugs* Flucytosine, Gentamicin with vancomycin, Netilmicin, Teicopla- nin, Tobramycin.

Human blood/plasma: Cyclosporin, Everolimus, Immunosuppressive drugs** Mycophenolate, Sirolimus, Tacrolimus.

Note: Test materials and analytes may be added or removed, please see current application form. *These analytes are produced in collaboration with UKNEQAS scheme for antibiotic drugs. **Please note this is not a HEATHCONTROL scheme and as such is not covered by the LGC Standards scope of accreditation. It is managed and operated by ASI Ltd. Participants may subscribe to the scheme through LGC Standards. HEATHCONTROL – Toxicology (TOX) The TOX scheme provides a range of test materials suitable for a variety of clinical and The Toxicology (TOX) scheme is designed to forensic settings: provide an independent performance assessment for laboratories and clinics that provide a • Serum, blood and urine. The blood and pathology service, toxicological service, or serum specimens contain ethanol, paracetamol forensic investigation service for drug and and salicylate (the blood also contains ethanol determination. The TOX scheme is carboxyhaemoglobin). The urine contains fully accredited in the U.K. by Clinical Pathology alcohol only. These are result driven samples Accreditation (CPA). and no interpretation is required. • Case study. A case study is provided along Drug and alcohol analyses may be undertaken with relevant serum and urine specimens. for a variety of reasons which include but are Participants analyse the specimens and not restricted to: submit the analytical findings along with the • Determine whether an individual is under the relevant interpretation, which is then marked influence of alcohol and/or drugs that may by an independent scoring panel. require treatment or interfere with any • Toxicological quantitative specimens. Blood medical care necessary (These analyses are test materials containing variable drugs and usually required quickly in order to facilitate compounds that may be monitored in cases effective medical treatment). of possible drug overdose. • Determine whether an individual is under the The full range and availability of test materials influence of alcohol and/or drugs which may in TOX is determined on an annual basis and put their own life or that of others at risk further details can be found in the TOX whilst at work. application form and scheme information • Determine whether an individual may have document. been affected by alcohol and/or drugs whilst either a victim or a suspect in a criminal Test material Analytes offence. • Determine whether alcohol and/or drugs may Human serum Ethanol, Paracetamol, Salicylate.

be implicated in a death. Blood Carboxyhaemoglobin, Ethanol, Paracetamol, Salicylate. Toxicological analyses may be undertaken on a Urine Ethanol. number of biological specimens, predominantly Human serum and urine Various analytes with clinical or blood, serum and urine. In general, analyses forensic scenario. are commonly undertaken for a range of Blood toxicology analytes Antipsychotics, Benzodiazepines, prescription and non-prescription drugs, illegal Opiates, Opioids, Selective drugs and alcohol. The aim of the analyses is to Serotonin Re-uptake Inhibitors (SSRIs), Tricyclic antidepressants, establish the identity of any substances present and other drugs of interest. and at what quantity, and to then Note: Test materials and analytes may be added or removed, please see determine what effect the substance(s) current application form. identified may have had on the individual. The analytical findings would then be subject to interpretation by a suitably qualified individual. HEATHCONTROL – Drugs of Abuse in Urine (DAU)

The Drugs of Abuse in Urine (DAU) scheme is designed to provide an independent performance assessment of laboratories and clinics that provide routine services for detection of drugs of abuse in urine. The DAU scheme is fully accredited in the U.K. by Clini- cal Pathology Accreditation (CPA).

Human urine has been used for many years to detect the presence of frequently abused drugs. A urine drug test may be undertaken when ordered by a doctor to monitor a known or sus- pected substance abuse patient, and whenever a person has symptoms that suggest drug use. Urine drug tests may be requested for a variety of reasons, including occupational monitoring, insurance screening, legal and forensic purposes and in sports. Drug testing is extremely accurate and reliable when all aspects of the testing process are For most drugs of abuse testing, results of carried out correctly. However, if poor procedures initial screening testing are compared with a and inadequate testing methods are utilised, the predetermined cut-off. Anything below that information obtained may be very misleading and cut-off is considered a negative result. A inaccurate. In order to minimise this risk, clinical negative result does not necessarily mean that laboratories should perform routine quality the person did not take a drug at some point, control tests and participate in suitable PT/EQA only that the drug was not present at a schemes. concentration greater than the reporting threshold. Anything above the cut-off is The full range and availability of test materials considered a positive result. If the sample is in DAU is determined on an annual basis and conﬁrmed as positive after secondary testing further details can be found in the DAU application then a “detected” ﬁnding is reported. form and scheme information document.

Test material Analytes

Urine test materials obtained from Amfetamines & stimulants, volunteers, patients and known Cannabinoids, Cocaine & metabolites drug users which regularly contain Minor tranquillizers, mixtures of drugs and their Non-opiate narcotics, Opiates. metabolites from six major classes

Note: Test materials and analytes may be added or removed, please see current application form. HEATHCONTROL – Drugs in Oral Fluid (DOF)

The Drugs in Oral Fluid (DOF) scheme is designed to provide an independent performance assessment of laboratories and clinics that provide analytical services for drugs in oral ﬂuid. The DOF scheme is fully accredited in the U.K. by Clinical Pathology Accreditation (CPA).

Drug abuse is a global problem affecting many in society. Advances in technology have enabled oral ﬂuid testing for the presence of many drugs, such as the amfetamines and stimulants, benzodiazepines, cannabinoids, cocaine and metabolites, opiates and non-opiate narcotics.

Oral fluid as a testing matrix is increasingly being utilised in a range of applications, such Due to the importance of results obtained it as work place monitoring, clinical toxicology is essential that laboratories undertaking the and criminal justice. analyses are able to demonstrate the testing The advantages of oral fluid over traditional they perform is dependable, reproducible and fluids such as blood and urine, are that accurate. Participation in the DOF scheme collection is almost non-invasive, is relatively will provide valuable feedback to laboratories/ easy to perform, and, in forensic situations, can on-site screening clinics who undertake these be achieved under close supervision to prevent analyses, and a record of results overtime. adulteration or substitution of the samples. The full range and availability of test materials There are now sensitive and reliable analytical in DOF is determined on an annual basis and methods available for oral fluid specimen further details can be found in the DOF collection, point-of-collection testing devices application form and scheme information (POCT), screening and confirmation methods. document.

Test material Analytes

Oral ﬂuid test materials obtained Amfetamines & stimulants, from volunteers and known drug Benzodiazepines, Cannabinoids, users. These regularly contain Cocaine & metabolites, mixtures of drugs and their Non-opiate narcotics, Opiates. metabolites from six major classes

Note: Test materials and analytes may be added or removed, please see current application form. QUARTZ – Forensic blood toxicology Test material Analytes scheme Group A 6MAM (MACM), Amfetamine, More frequently determined drugs Amisulpride, Amitriptyline, QUARTZ is a blood toxicology scheme designed Benzoylecgonine, Buprenorphine, for laboratories undertaking analysis of drugs Carbamazepine, Chlordiazepoxide, Chlorpromazine, Citalopram, in post-mortem and other blood samples for Clomipramine, Clozapine, Cocaine, toxicological purposes, particularly in a forensic Codeine, Cyclizine, Desmethyldiazepam, Diazepam, context. Test materials are prepared using Diclofenac, Dihydrocodeine, Diphenhydramine, Dosulepin, pre-screened human blood. Target analytes Fentanyl, Fluoxetine, Ibuprofen, are added at an appropriate level and the test Imipramine, Ketamine, Lamotrigine, MDA, MDMA, material mixed to ensure homogeneity prior Methadone, Methamphetamine, to despatch. Midazolam, Mirtazepine, Morphine, Olanzapine, Oxazepam, Oxyco- done, Paracetamol, Paroxetine, The analytes to be determined in each round Pethidine, Phenytoin, Procyclidine, are from a list of non-prescription, prescription Promethazine, Propoxyphene, Quetiapine, Risperidone, Salicylate, and controlled drugs, as well as other toxins, Sertraline, Temazepam,THC, compiled by the Advisory Group, which reﬂects THC-COOH,Tramadol, Venlafaxine, Zolpidem, Zopiclone. what participants are likely to encounter in Group B Amlodipine, Amobarbital, Atenolol, forensic casework. Less frequently determined drugs Benzyl piperazine (BZP), Butobarbital, Clobazam, The test materials are subdivided into two Clomethiazole, Clonazepam, Dextromoramide, Dipipanone, groups: Gabapentin, Loprazolam, Lormetazepam, Mefenamic Acid, Group A: those drugs that are more frequently Methylphenidate, Naltrexone, Pentobarbital, Phenelzine, determined by participants. Propranolol, Secobarbital, Sildenaﬁl, Thioridazine, Trazadone, Group B: those drugs that may be less Zaleplon. frequently determined by participants. Note: Metabolites of the above substances may also be added.

Up to three test materials are provided in each Test material Analytes round containing between 0 and 4 drugs. Drug Identification Participants will be asked to identify the drug(s) only. The test material Alcohol is major cause of road casualties and will always (if positive) contain one deaths and as penalties for drink-driving are drug from Group A. Up to three other drugs may be in the test severe it is essential the accuracy of analysis material from either Group A and/ can be proven in the legal case. The test material or Group B. comprises 10ml vial of whole blood containing Drug Quantification Participants will be told the identity, alcohol for analysis. or generic classification, of the drug(s), and asked to quantify the concentration. They will also be The full range and availability of test materials asked to give an interpretation of in QUARTZ is determined on an annual basis the results in respect to a case study provided. The test material and further details can be found in the QUARTZ will always contain a drug from Group A. Any other drugs present application form and scheme description. will be from Group A and/or Group B.

Drug Quantiﬁcation Standard solutions containing drugs for the evaluation of instrumentation.

Alcohol Quantiﬁcation Participants will be required to quantify the alcohol concentration by their usual methods.

Note: Test materials and analytes may be added or removed, please see current application form. FORENSICS PT trial scheme

LGC Standards Proﬁciency Testing has developed a range of trials for the Forensic Science sector. These are intended to complement the quality control and quality assurance products already well established in these specialised laboratories, in order to help demonstrate the efﬁcacy of these measures.

The trials may comprise:

• Qualitative tests; confirmatory testing and/or identification. • Quantitative tests; analysis of specified component(s). • Post-analytical challenges/scientific conclusion; interpretation based on a case study and analytical data.

Participants may use any method they deem Test material Analytes appropriate to perform the test or analyse the Alcohol Technical Defence* Participants will be asked to use the data. If the method used inﬂuences the result, available information to establish the likely level of intoxication of a it will be possible to identify this through analysis suspect at a given time. Data of the data submitted, and give feedback in provided will include analytical results and an alleged case the report. scenario or witness statement.

The full range and availability of test materials DNA* Participants will be asked to use the available information to establish in FORENSICS PT is determined on an annual the suitability of a mixture of DNA proﬁles for designation. Data avail- basis and further details can be found in the able may include print outs of elec- FORENSICS PT application form and scheme trophoretograms from GMID, an excel table of peak data exported description. from GMID, and .fsa ﬁles generated by AB Data Collection software.

Drugs* Participants will be asked to use the available information to establish the identity of an unknown powder submitted for drugs proﬁling. Data provided will include a brief summary of the investigative approach, chromatograms or similar of the suspect powder from appropriate analytical technique (e.g. GC-MS). Results for reference materials/ calibrants analysed simultaneously.

Questioned Documents* Participants will receive a piece of paper with a series of ink marks, and up to three suspect writing implements or comparison documents. The hypothesis to be tested will be described in detail.

Note: Test materials and analytes may be added or removed, please see current application form. *Please note these trials are currently not included in our scope of accreditation. PHARMASSURE - Pharmaceutical scheme The full range and availability of test materials in PHARMASSURE is determined on an annual PHARMASSURE has been speciﬁcally de- basis and further details can be found in the signed to meet the needs of the pharmaceutical PHARMASSURE application form and scheme industry. The reduction of risks associated with description. the manufacture of pharmaceutical products is the primary objective of the pharmaceuti- Test material Analytes cal quality assurance laboratory. There is an abundance of regulations, biological standards, Sample 1 Acid/Base Titration, Density, Melting Basic chemical analysis Point, Other Basic Titration (actual ana- validation procedures and other tools available lytes dependant on test), pH, Refractive Index to the quality control professional to achieve this aim. In most cases however, the use of Sample 2 Advanced Titration (e.g. Potentio-met- Advanced chemical testing ric, Non-Aqueous), Flame these tools is aimed at assessing the product Spectroscopy, FTIR, GC, Polarimetry, or the environment in which it was produced. UV/TLC, Viscosity

The introduction of proficiency testing offers Sample 2A HPLC a valuable independent tool for the ongoing HPLC assessment of the testing procedures, methods employed, laboratory staff responsible for Sample 3 A low inoculum level test material for Microbiological identification enumeration by membrane filtration the analysis and subsequent interpretation of and identification results.

Sample 4 A high inoculum leven material for Microbiological enumeration enumeration of Total aerobic mesophilic The regulations surrounding the manufacture of bacteria, Staphyloccus aureus, pharmaceutical products and the laboratories Escherichia coli, Yeast and mould which test them are wideranging, and compli- Sample 5 A set of 5 test materials each to be ance with the requirements of GMP/GLP are Sterility testing tested for sterility aimed at ensuring the safety and efficacy of all pharmaceutical preparations. Similarly, the annual revalidation of methods is an important Note: Test materials and analytes may be added or removed, please see current application form. tool in understanding and ensuring that a testing method is working properly. However, these tools are largely internal operations. Regular participation in a PT scheme, provides an external independent tool for monitoring the ef- fectiveness of methods employed in any laboratory, without the work involved in a full method revalidation. The test materials cover chemical and microbiological analysis. The sterility test is ideally suited to ongoing assessment and provides staff involved in the analysis and in interpretation of results with a tool to ensure that low level contamination events which occur particularly infrequently – and often not at all over the course of a testing year – are identified and the results correctly interpreted. PHYTAS - Phytochemical Testing Assurance The analysis of such a wide range of com- Scheme pounds, in what is by definition an incre- dibly diverse range of matrices, is not always PHYTAS has been developed in response to straightforward and there is little standardisa- demands from the phytochemical industry. In tion of methodologies from laboratory to labora- recent times there has been a huge amount of tory. One of the major concerns in a relatively media attention and popular interest in medi- new and broad field of analysis is the lack of cinal plants and chemicals they contain. These standardised methods and even definition of plant materials are highly valued for the role the ‘required’ components for analysis. they can play in promoting and sustaining human health. Plants have evolved and produce Proficiency testing is an important tool in the an array of secondary compounds, many of improvement of analytical performance in which have been used in traditional medicines scientific disciplines such as this and by stan- and remedies for hundreds of years. dardisation the quality of analysis, one of the variables is removed - helping to achieve con- The most common classes of ‘active’ com- sistency in the quality of the finished product for pounds found in medicinal plants are alkaloids, the consumer. terpenoids, phenols, and glycosides, though the range of compounds is by no means limited The full range and availbility of test materials in to this four classes. As extracts of living matter, PHYTAS is determined on an annual basis and the quality and potency of botanical products further details can be found in PHYTAS applica- is subject to variation, giving rise to uncertainty tion form and scheme description. amongst consumers, analysts and regulators alike.

Test material Analytes

Botanical Identiﬁcation and quantiﬁcation of a range of active ingredients

Note: Test materials and analytes may be added or removed, please see current application form. PHYTAS is currently not included in our scope of accreditation. Conﬁdentiality Other PT services

In order to ensure confidentiality, participants in • Advice and consultancy for potential all schemes are allocated a unique laboratory PT providers. reference number. This number enables results • Consultancy for PT providers in the to be reported without divulging the identities implementation of appropriate quality of participant laboratories. systems. • Training courses for PT participants and their However it should be noted that, where required, customers. the performance of U.K. participants is reported • Prominent role in the development of policy to the National Quality Assurance Advisory and guidance for proficiency testing by Panels for Chemical Pathology and for Medical representing the UK on a number of key Microbiology as appropriate. international committees. Reports Product development If PT/EQA schemes are to be effective in LGC Standards Proficiency Testing is continually facilitating improvements in the testing striving to improve current products and to undertaken by participating laboratories, introduce new test materials and PT schemes analyses of the results need to be returned to where appropriate. New products may be participants quickly. The HEATHCONTROL introduced initially on a trial basis and offered to reports are issued promptly within two - four participants. It will be made clear to participants weeks of the reporting deadline and are when they are participating in a trial. received as paper copies. The content of the reports vary from scheme to scheme but If you have a requirement for a new analyte, includes details of the composition of the test test material matrix, or a whole new scheme materials, the assigned value, the spiked value, please contact: [email protected] performance scores (BIS score) for each laboratory, and tabular and/or graphical representation of participant results.

The PHARMASSURE, PHYTAS, and QUARTZ scheme, as well as the FORENSIC PT Trial results are returned through our electronic reporting software, PORTAL. Full instructions for the use of the PORTAL system are provided on registration; features include result reporting by multiple analysts and using multiple methods. Following evaluation of the results, the PHAR- MASSURE, PHYTAS, QUARTZ and Forensics PT Trial reports are available on the website, or sent by email within 10 - 15 working days, respectively of round closure. Participants will be emailed a link to the report when it is available. Reference materials Summary

Before a correct interpretation can be applied Proficiency testing (or EQA) is widely used to a diagnostic measurement, clinicians must across many scientific disciplines as an integral have confidence that target analytes have been part of the quality control and risk reduction pro- correctly identified and quantified. For many cess. Participation in these schemes provides analytical methods, this can only be achieved the analytical laboratory with the ability to assess through the use of appropriately certified and performance on an ongoing basis and characterised reference materials benchmark that performance against other laboratories while maintaining anonymity. As a leading global supplier of reference materials, LGC Standards offers a broad range The ongoing assessment of performance using of measurement standards for routine clinical proficiency testing allows the identification of applications, such as therapeutic drug monitoring, areas for training and improvement and may occupational health, drugs and drugs of abuse, also assist with audit processes. molecular biology and veterinary medicine.

We offer a range of certiﬁed reference materials (CRM) to assist, for example, manufacturers complying with the European in vitro diagnostics Directive 98/79/EC. These higher order reference materials are produced by metrological institutes and organisations and are precisely characterised.

For further information or to receive our catalogue, please contact your local ofﬁce or visit our website: www.lgcstandards.com Code number index

AC-SE30-030 ...... 48 CAY-13219 ...... 99 CDX-00004065-005 ... 170 CDX-00014378-010 ... 171 Code AC-SE40-015 ...... 48 CAY-13636 ...... 123 CDX-00004065-010 ... 170 CDX-00016010-005 ... 171 AC-SE40-030 ...... 48 CAY-13824 ...... 122 CDX-00004066-010 ... 170 CDX-00016010-010 ... 172 number AC-SE50-015 ...... 48 CAY-16851 ...... 99 CDX-00004075-005 ... 170 CDX-00016011-001 ... 171 AC-SE50-030 ...... 48 CAY-9000851-5 ...... 122 CDX-00004075-010 ... 170 CDX-00016011-005 ... 171 index AC-UR015.010.001 22, 51 CAY-9000855 ...... 122 CDX-00004076-005 ... 170 CDX-00016316-005 ... 172 AC-AQ01-015 ...... 45 AC-UR015.040.001 ... 187 CAY-9000856 ...... 122 CDX-00004076-010 ... 170 CDX-00016317-005 ... 172 AC-AQ01-030 ...... 45 AC-UR015.040.002 ... 187 CAY-9000861 ...... 122 CDX-00004077-005 ... 170 CDX-00016318-005 ... 172 AC-AQ02-015 ...... 45 AC-UR015.050.003 ... 194 CAY-9000866 ...... 122 CDX-00004077-010 ... 170 CDX-00018040-010 ... 172 AC-AQ02-030 ...... 45 AC-UR015.050.004 ... 194 CAY-90082 ...... 116 CDX-00004078-005 ... 170 CDX-00018040-025 ... 172 AC-AQ03-015 ...... 45 AC-UR15.025.005.001 13 CAY-90084 ...... 99 CDX-00004078-010 ... 170 CDX-00018041-010 ... 172 AC-AQ03-030 ...... 45 AC-WH015.015.001 .. 194 CDX-00001006-010 .. 168 CDX-00004079-005 ... 170 CDX-00018041-025 ... 172 AC-AQ05-015 ...... 45 AC-WH015.025.015.001 CDX-00001006-050 .. 168 CDX-00004079-010 ... 170 CDX-00018050-001 ... 172 AC-AQ05-030 ...... 45 ...... 14 CDX-00001099-005 .. 168 CDX-00004080-005 ... 170 CDX-00018050-010 ... 172 AC-AQ08-015 ...... 45 AC-WH03-015 ...... 50 CDX-00001099-010 .. 169 CDX-00004080-010 ... 170 CDX-00018295-005 ... 172 AC-AQ08-030 ...... 45 AC-WH03-030 ...... 50 CDX-00001121-005 .. 168 CDX-00004236-005 ... 170 CDX-00019039-010 ... 172 AC-AQ10-015 ...... 45 AC-WH05-015 ...... 50 CDX-00001121-010 .. 168 CDX-00004236-010 ... 170 CDX-00019039-025 ... 172 AC-AQ10-030 ...... 45 AC-WH05-030 ...... 50 CDX-00001151-005 .. 168 CDX-00004461-005 ... 170 CDX-00019042-001 ... 172 AC-AQ11-015 ...... 45 AC-WH08-015 ...... 50 CDX-00001151-010 .. 168 CDX-00004461-010 ... 170 CDX-00019045-010 ... 172 AC-AQ11-030 ...... 45 AC-WH08-030 ...... 50 CDX-00001302-005 .. 168 CDX-00004462-005 ... 169 CDX-00019047-005 ... 172 AC-AQ13-015 ...... 45 AC-WH11-015 ...... 50 CDX-00001302-010 .. 168 CDX-00004462-010 ... 169 CDX-00019047-010 ... 172 AC-AQ13-030 ...... 45 AC-WH11-030 ...... 50 CDX-00001303-005 .. 168 CDX-00004476-005 ... 170 CDX-00019050-010 ... 172 AC-AQ15-015 ...... 45 AC-WH20-015 ...... 50 CDX-00001303-010 .. 168 CDX-00004476-010 ... 170 CDX-00019089-010 ... 172 AC-AQ15-030 ...... 45 AC-WH20-030 ...... 50 CDX-00001304-005 .. 168 CDX-00004477-005 ... 170 CDX-00019089-250 ... 172 AC-AQ20-015 ...... 45 ALL-013641 ...... 153 CDX-00001339-005 .. 168 CDX-00004477-010 ... 170 CDX-00019135-005 ... 172 AC-AQ20-030 ...... 45 ALL-013661 ...... 153 CDX-00001339-010 .. 168 CDX-00005018-020 ... 170 CDX-00019135-010 ... 172 AC-AQ30-015 ...... 45 ATH0902-10 ...... 50 CDX-00001340-005 .. 168 CDX-00005114-010 ... 170 CDX-00019139-005 ... 172 AC-AQ30-030 ...... 45 ATH0902D-10...... 50 CDX-00001340-010 .. 168 CDX-00005114-025 ... 170 CDX-00019140-005 ... 172 AC-AQ40-015 ...... 45 BCR-165 ...... 37 CDX-00001491-010 .. 168 CDX-00005115-005 ... 170 CDX-00019140-010 ... 172 AC-AQ40-030 ...... 45 BCR-166 ...... 37 CDX-00001491-050 .. 168 CDX-00005115-010 ... 170 CDX-00019373-100 ... 172 AC-AQ50-015 ...... 45 BCR-167 ...... 37 CDX-00001492-050 .. 168 CDX-00005116-005 ... 170 CDX-00019373-250 ... 172 AC-AQ50-030 ...... 45 BCR-273 ...... 30 CDX-00001495-010 .. 168 CDX-00005116-010 ... 170 CDX-00020041-005 ... 172 AC-HA015.045.002 .... 190 BCR-299 ...... 17 CDX-00001495-025 .. 168 CDX-00005117-010 ... 170 CDX-00020041-010 ... 172 AC-SE01-015 ...... 48 BCR-304 ...... 15 CDX-00001499-010 .. 172 CDX-00007241-025 ... 170 CDX-00020042-005 ... 172 AC-SE01-030 ...... 48 BCR-348R ...... 24 CDX-00001645-001 .. 168 CDX-00007241-100 ... 170 CDX-00020042-010 ... 172 AC-SE015.010.001 20, 51 BCR-386 ...... 32 CDX-00001645-010 .. 168 CDX-00008040-001 ... 170 CDX-00020043-005 ... 172 AC-SE015.015.001 .... 192 BCR-387 ...... 32 CDX-00001671-005 .. 168 CDX-00008040-100 ... 170 CDX-00020043-010 ... 172 AC-SE015.015.003 .... 192 BCR-388 ...... 32 CDX-00001740-010 .. 168 CDX-00008041-001 ... 170 CDX-00020062-005 ... 172 AC-SE015.025.010.001 BCR-389 ...... 32 CDX-00001745-010 .. 168 CDX-00008041-100 ... 170 CDX-00020062-010 ... 172 ...... 13 BCR-390 ...... 32 CDX-00001747-005 .. 168 CDX-00008045-025 ... 171 CDX-00020064-005 ... 172 AC-SE015.040.001 .... 187 BCR-391 ...... 32 CDX-00002003-005 .. 169 CDX-00008045-100 ... 171 CDX-00020064-010 ... 172 AC-SE015.040.002 .... 187 BCR-393 ...... 30 CDX-00002003-010 .. 169 CDX-00008046-100 ... 171 CDX-00020067-005 ... 172 AC-SE015.040.005.003 BCR-405 ...... 32 CDX-00002004-005 .. 169 CDX-00008046-500 ... 171 CDX-00020067-010 ... 172 ...... 182 BCR-410 ...... 17 CDX-00002004-010 .. 169 CDX-00008050-025 ... 170 CDX-00020070-005 ... 172 AC-SE015.040.005.004 BCR-457 ...... 31 CDX-00002059-010 .. 169 CDX-00008050-100 ... 171 CDX-00020070-010 ... 172 ...... 183 BCR-486 ...... 30 CDX-00002170-010 .. 169 CDX-00008051-500 ... 170 CDX-00020071-005 ... 172 AC-SE015.040.005.005 BCR-522 ...... 31 CDX-00002170-025 .. 169 CDX-00008326-010 ... 171 CDX-00020071-010 ... 172 ...... 183 BCR-573 ...... 20 CDX-00002171-010 .. 169 CDX-00008326-025 ... 171 CDX-00020072-005 ... 173 AC-SE015.040.005.006 BCR-573I ...... 20 CDX-00002171-025 .. 169 CDX-00008624-005 ... 171 CDX-00020072-010 ... 173 ...... 183 BCR-574 ...... 20 CDX-00002200-005 .. 169 CDX-00008720-010 ... 171 CDX-00020075-0SM . 172 AC-SE015.040.009.001 BCR-575 ...... 20 CDX-00002200-010 .. 169 CDX-00008875-010 ... 171 CDX-00020480-010 ... 173 ...... 182 BCR-576 ...... 24 CDX-00002201-010 .. 169 CDX-00008875-050 ... 171 CDX-00020480-050 ... 173 AC-SE015.040.015.001 BCR-577 ...... 24 CDX-00002201-025 .. 169 CDX-00008876-010 ... 171 CDX-00020481-010 ... 173 ...... 185 BCR-578 ...... 24 CDX-00002469-005 .. 169 CDX-00008900-005 ... 171 CDX-00020481-050 ... 173 AC-SE015.040.015.002 BCR-613 ...... 30 CDX-00002469-010 .. 169 CDX-00008900-010 ... 171 CDX-00020482-010 ... 173 ...... 185 BCR-634 ...... 23, 25 CDX-00003035-001 .... 34 CDX-00009025-002 ... 171 CDX-00020482-050 ... 173 AC-SE015.040.015.003 BCR-635 ...... 23, 25 CDX-00003035-500 .... 34 CDX-00010200-010 ... 171 CDX-00020483-010 ... 173 ...... 186 BCR-636 ...... 23, 25 CDX-00003360-005 .. 169 CDX-00010200-050 ... 171 CDX-00020483-050 ... 173 AC-SE015.040.015.004 BCR-637 ...... 27 CDX-00003360-010 .. 169 CDX-00011002-005 ... 168 CDX-00020484-010 ... 173 ...... 186 BCR-638 ...... 27 CDX-00003395-005 .. 169 CDX-00011002-010 ... 168 CDX-00020491-010 ... 173 AC-SE015.040.015.005 BCR-639 ...... 27 CDX-00003396-005 .. 169 CDX-00011004-005 ... 168 CDX-00020491-100 ... 173 ...... 186 BCR-647 ...... 16 CDX-00003396-010 .. 169 CDX-00011012-005 ... 168 CDX-00022460-005 ... 173 AC-SE015.040.015.006 BCR-665 ...... 30 CDX-00003400-010 .. 169 CDX-00011012-010 ... 168 CDX-00022460-010 ... 173 ...... 186 BCR-666 ...... 30 CDX-00003405-010 .. 169 CDX-00011074-010 ... 169 CDX-00024920-005 ... 173 AC-SE015.040.020.001 BCR-693 ...... 17 ...... 181 CDX-00003405-025 .. 169 CDX-00011074-025 ... 169 CDX-00024920-010 ... 168 BCR-694 ...... 17 AC-SE015.040.020.002 CDX-00003406-010 .. 169 CDX-00011075-001 ... 169 CDX-00024921-005 ... 173 ...... 181 B-MYC0610-1.2 ...... 201 CDX-00003406-025 .. 169 CDX-00011075-010 ... 169 CDX-00024921-010 ... 173 AC-SE02-015 ...... 48 CAY-10005673 ...... 116 CDX-00003730-025 .. 169 CDX-00011300-005 ... 171 CDX-00025010-005 ... 168 AC-SE02-030 ...... 48 CAY-10009018 ...... 121 CDX-00003735-005 .. 169 CDX-00011300-010 ... 171 CDX-00025010-010 ... 168 AC-SE03-015 ...... 48 CAY-10266 ...... 121 CDX-00003735-025 .. 169 CDX-00011305-001 ... 171 CDX-00025509-010 ... 168 AC-SE03-030 ...... 48 CAY-10486 ...... 121 CDX-00003745-010 .. 169 CDX-00011310-005 ... 171 CDX-00025509-025 ... 168 AC-SE05-015 ...... 48 CAY-10510 ...... 123 CDX-00003745-025 .. 169 CDX-00011310-010 ... 171 CDX-00025510-025 ... 168 AC-SE05-030 ...... 48 CAY-10511 ...... 122 CDX-00003746-010 .. 169 CDX-00012073-005 ... 171 CDX-00025512-010 ... 168 AC-SE08-015 ...... 48 CAY-10512 ...... 122 CDX-00003765-010 .. 169 CDX-00012073-010 ... 171 CDX-00025512-025 ... 168 AC-SE08-030 ...... 48 CAY-10578 ...... 123 CDX-00003770-005 .. 169 CDX-00013860-005 ... 171 CDX-00030622-005 ... 172 AC-SE10-015 ...... 48 CAY-10644 ...... 123 CDX-00003770-010 .. 169 CDX-00013860-010 ... 171 CDX-00030964-005 ... 171 AC-SE10-030 ...... 48 CAY-10660 ...... 121 CDX-00003812-010 .. 169 CDX-00013889-005 ... 171 CDX-00030965-005 ... 172 AC-SE11-015 ...... 48 CAY-10661 ...... 123 CDX-00003812-025 .. 169 CDX-00013889-010 ... 171 CDX-00031065-005 ... 169 AC-SE11-030 ...... 48 CAY-10682 ...... 123 CDX-00003813-025 .. 169 CDX-00013890-005 ... 171 CDX-00031065-010 ... 170 AC-SE13-015 ...... 48 CAY-10691 ...... 122 CDX-00003983-005 .. 169 CDX-00013890-010 ... 171 CDX-00031085-001 ... 171 AC-SE13-030 ...... 48 CAY-10697 ...... 122 CDX-00004024-005 .. 170 CDX-00013907-005 ... 171 CDX-00031086-250 ... 171 AC-SE15-015 ...... 48 CAY-10721 ...... 123 CDX-00004024-010 .. 170 CDX-00013935-010 ... 171 CEN DMR-263A ...... 21 AC-SE15-030 ...... 48 CAY-10722 ...... 123 CDX-00004059-005 .. 170 CDX-00013935-100 ... 171 CER-720-1 ...... 13 AC-SE20-015 ...... 48 CAY-13170 ...... 122 CDX-00004059-010 .. 170 CDX-00013955-005 ... 171 CER-720-2 ...... 13 AC-SE20-030 ...... 48 CAY-13171 ...... 122 CDX-00004060-005 .. 170 CDX-00013955-010 ... 171 CER-720-3 ...... 13 AC-SE30-015 ...... 48 CAY-13218 ...... 99 CDX-00004060-010 .. 170 CDX-00014378-005 ... 171 CERA-002 ...... 86

232 LGC Standards – Excellence through measurement Edition 2011/2012

Code number index

CERA-003 ...... 82 CERB-035 ...... 91 CERD-033 ...... 105 CERE-052 ...... 111 CERH-038 ...... 115 CERA-005 ...... 86 CERB-037 ...... 92 CERD-034 ...... 104 CERE-053 ...... 43 CERH-041 ...... 120 CERA-006 ...... 83 CERB-042 ...... 90 CERD-035 ...... 106 CERE-056 ...... 42 CERH-047 ...... 116 CERA-007 ...... 86 CERB-044 ...... 91 CERD-040 ...... 100 CERE-057 ...... 109 CERH-048 ...... 116 CERA-008 ...... 86 CERB-045 ...... 92 CERD-041 ...... 104 CERE-062 ...... 109 CERH-049 ...... 117 CERA-009 ...... 83 CERB-046 ...... 92 CERD-044 ...... 108 CERE-063 ...... 111 CERH-050 ...... 117 CERA-010 ...... 83 CERB-901 ...... 91 CERD-046 ...... 99 CERE-064 ...... 111 CERH-051 ...... 117 CERA-011 ...... 86 CERB-902 ...... 91 CERD-047 ...... 101 CERE-066 ...... 111 CERH-052 ...... 118 CERA-013 ...... 86 CERB-903 ...... 90 CERD-048 ...... 101 CERE-067 ...... 111 CERH-053 ...... 118 CERA-016 ...... 86 CERB-906 ...... 89 CERD-049 ...... 101 CERE-071 ...... 111 CERH-054 ...... 120 CERA-017 ...... 86 CERB-907 ...... 89 CERD-050 ...... 105 CERE-072 ...... 111 CERH-055 ...... 120 CERA-018 ...... 86 CERB-908 ...... 91 CERD-051 ...... 107 CERE-074 ...... 110, 200 CERH-059 ...... 201 CERA-019 ...... 87 CERC-004 ...... 97 CERD-052 ...... 103 CERE-075 ...... 110, 200 CERH-060 ...... 118 CERA-020 ...... 86 CERC-005 ...... 97 CERD-054 ...... 107 CERE-076 ...... 111 CERH-061 ...... 118 CERA-026 ...... 83 CERC-006 ...... 97 CERD-055 ...... 100 CERE-901 ...... 110 CERH-062 ...... 118 CERA-027 ...... 83 CERC-007 ...... 98 CERD-056 ...... 100 CERE-903 ...... 110 CERH-063 ...... 118 CERA-034 ...... 87 CERC-008 ...... 97 CERD-058 ...... 103 CERE-905 ...... 205 CERH-064 ...... 118 CERA-036 ...... 87 CERC-009 ...... 96 CERD-059 ...... 105 CERE-908 ...... 204 CERH-066 ...... 118 CERA-038 ...... 86 CERC-010 ...... 96 CERD-060 ...... 107 CERE-910 ...... 204 CERH-073 ...... 33, 120 CERA-040 ...... 85 CERC-014 ...... 97 CERD-061 ...... 199 CERE-911 ...... 205 CERH-074 ...... 33, 120 CERA-044 ...... 86 CERC-015 ...... 97 CERD-062 ...... 200 CERERA-017 ...... 162 CERH-076 ...... 119 CERA-045 ...... 86 CERC-016 ...... 98 CERD-063 ...... 206 CERERA-018 ...... 162 CERH-077 ...... 119 CERA-046 ...... 88 CERC-017 ...... 98 CERD-064 ...... 206 CERERA-022S ...... 162 CERH-078 ...... 117 CERA-049 ...... 86 CERC-019 ...... 93 CERD-065 ...... 206 CERERA-023S ...... 162 CERH-081 ...... 119 CERA-053 ...... 82 CERC-022 ...... 93 CERD-066 ...... 99, 206 CERERD-032S ...... 162 CERH-083 ...... 33, 121 CERA-054 ...... 43 CERC-024 ...... 96 CERD-067 ...... 105 CERERD-033S ...... 162 CERH-085 ...... 120 CERA-056 ...... 43 CERC-028 ...... 93 CERD-068 ...... 108 CERERD-034S ...... 162 CERH-086 ...... 33, 121 CERA-057 ...... 43 CERC-033 ...... 96 CERD-069 ...... 102 CERERD-079 ...... 162 CERH-087 ...... 33, 120 CERA-060 ...... 85 CERC-035 ...... 98 CERD-070 ...... 102 CERERD-080 ...... 162 CERH-089 ... 33, 105, 115 CERA-061 ...... 43 CERC-036 ...... 94 CERD-071 ...... 104 CERERD-081 ...... 162 CERH-090 ...... 33, 105 CERA-064 ...... 82, 147 CERC-039 ...... 97 CERD-072 ...... 107 CERERD-109S ...... 162 CERH-091 ...... 199 CERA-066 ...... 83 CERC-040 ...... 98 CERD-073 ...... 210 CERERD-115S ...... 162 CERH-092 ...... 199 CERA-067 ...... 83 CERC-041 ...... 98 CERD-076 ...... 100 CERERD-138 ...... 162 CERH-093 ...... 119 CERA-071 ...... 83 CERC-042 ...... 93 CERD-079 ...... 99 CERERD-148S ...... 162 CERH-902 ...... 119 CERA-072 ...... 88 CERC-045 ...... 92 CERD-080 ...... 100 CERERD-152S ...... 162 CERH-915 ...... 207 CERA-074 ...... 134 CERC-046 ...... 92 CERD-081 ...... 107 CERERE-011 ...... 162 CERH-918 ...... 119 CERA-076 ...... 43 CERC-051 ...... 92 CERD-902 ...... 104 CERERE-012 ...... 162 CERH-919 ...... 119 CERA-077 ...... 88 CERC-053 ...... 93 CERD-903 ...... 101 CERERE-021 ...... 163 CERH-921 ...... 119 CERA-078 ...... 88 CERC-055 ...... 95 CERD-906 ...... 101 CERERE-032S ...... 162 CERH-922 ...... 119 CERA-080 ...... 87 CERC-057 ...... 95 CERD-907 ...... 104 CERERE-042 ...... 163 CERH-923 ...... 119 CERA-081 ...... 87 CERC-059 ...... 96 CERD-908 ...... 107 CERERG-006 ...... 162 CERI-001 ...... 121 CERA-083 ...... 85 CERC-060 ...... 99 CERD-910 ...... 104 CERERH-004S ...... 162 CERI-009 ...... 121 CERA-084 ...... 87, 198 CERC-073 ...... 98 CERD-915 ...... 100 CERERN-004S ...... 162 CERI-010 ...... 121, 126 CERA-085 ...... 86 CERC-074 ...... 95 CERD-916 ...... 101 CERERN-005S ...... 162 CERI-902 ...... 121 CERA-093 ...... 88 CERC-077 ...... 93 CERD-918 ...... 102 CERERN-007S ...... 162 CERK-002 ...... 123 CERA-094 ...... 88 CERC-081 ...... 201 CERD-919 ...... 102 CERERR-001S ...... 162 CERK-003 ...... 123 CERA-095 ...... 88 CERC-087 ...... 98 CERD-920 ...... 103 CERERT-021S ...... 162 CERL-001 ...... 125 CERA-097 ...... 87 CERC-089 ...... 94 CERD-924 ...... 100 CERERT-022S ...... 162 CERL-002 ...... 126 CERA-902 ...... 84 CERC-090 ...... 95 CERD-925 ...... 102 CERERT-023S ...... 162 CERL-004 ...... 124 CERA-903 ...... 84 CERC-091 ...... 96 CERE-001 ...... 108 CERF-001 ...... 112 CERL-005 ...... 125 CERA-904 ...... 117 CERC-092 ...... 96 CERE-002 ...... 108 CERF-002 ...... 112 CERL-006 ...... 126 CERA-905 ...... 117 CERC-093 ...... 99 CERE-003 ...... 108 CERF-003 ...... 113 CERL-007 ...... 124 CERA-907 ...... 117 CERC-094 ...... 93 CERE-004 ...... 108 CERF-005 ...... 114 CERL-008 ...... 123 CERA-908 ...... 117 CERC-095 ...... 95 CERE-005 ...... 109 CERF-009 ...... 112 CERL-010 ...... 124 CERA-910 ...... 84 CERC-104 ...... 99 CERE-006 ...... 108 CERF-010 ...... 112 CERL-014 ...... 125 CERA-911 ...... 85 CERC-106 ...... 199 CERE-008 ...... 108 CERF-013 ...... 112 CERL-017 ...... 126, 142 CERA-912 ...... 84 CERC-108 ...... 99 CERE-011 ...... 109 CERF-901 ...... 118 CERL-018 ...... 124 CERA-913 ...... 85 CERC-109 ...... 199 CERE-012 ...... 109 CERF-902 ...... 119 CERL-021 ...... 125 CERA-914 ...... 85 CERC-110 ...... 199 CERE-015 ...... 111 CERF-903 ...... 113 CERL-023 ...... 124 CERA-915 ...... 84 CERC-111 ...... 93, 199 CERE-016 ...... 50, 111 CERF-907 ...... 112 CERL-025 ...... 124 CERA-916 ...... 84 CERC-114 ...... 99 CERE-018 ...... 110 CERF-909 ...... 113, 200 CERL-901 ...... 125 CERA-917 ...... 84 CERC-901 ...... 95 CERE-019 ...... 108 CERF-915 ...... 112 CERL-902 ...... 125 CERA-921 ...... 85 CERC-902 ...... 94 CERE-021 ...... 109 CERF-918 ...... 113 CERL-907 ...... 125 CERA-923 ...... 85 CERC-903 ...... 95 CERE-022 ...... 109 CERF-919 ...... 113 CERL-911 ...... 125 CERA-925 ...... 85 CERC-904 ...... 94 CERE-023 ...... 109 CERG-001 ...... 114 CERM-001 ...... 162 CERB-001 ...... 89 CERC-905 ...... 96 CERE-024 ...... 110 CERG-003 ...... 115 CERM-002 ...... 162 CERB-002 ...... 162 CERC-906 ...... 96 CERE-025 ...... 110 CERG-005 ...... 115 CERM-003 ...... 136 CERB-003 ...... 162 CERC-907 ...... 96 CERE-026 ...... 110 CERG-006 ...... 115 CERM-004 ...... 130 CERB-004 ...... 89 CERC-909 ...... 95 CERE-029 ...... 43 CERG-007 ...... 114 CERM-005 ...... 136 CERB-005 ...... 91 CERC-912 ...... 93 CERE-030 ...... 43 CERG-011 ...... 114 CERM-006 ...... 136 CERB-006 ...... 91 CERD-002 ...... 162 CERE-031 ...... 43 CERG-901 ...... 114 CERM-007 ...... 129 CERB-007 ...... 89 CERD-003 ...... 162 CERE-032 ...... 43 CERH-001 ...... 116 CERM-008 ...... 129 CERB-008 ...... 89 CERD-004 ...... 162 CERE-033 ...... 43 CERH-002 ...... 115 CERM-009 ...... 130 CERB-010 ...... 89 CERD-007 ...... 102 CERE-034 ...... 43 CERH-003 ...... 116 CERM-010 ...... 127 CERB-013 ...... 89 CERD-010 ...... 162 CERE-035 ...... 42 CERH-004 ...... 116 CERM-011 ...... 127 CERB-014 ...... 89 CERD-011 ...... 162 CERE-036 ...... 43 CERH-005 ...... 116 CERM-012 ...... 127 CERB-016 ...... 88 CERD-012 ...... 102 CERE-037 ...... 43 CERH-006 ...... 116 CERM-013 ...... 127 CERB-018 ...... 92, 114 CERD-013 ...... 103 CERE-038 ...... 43 CERH-008 ...... 116 CERM-014 ...... 130 CERB-020 ...... 92 CERD-015 ...... 107 CERE-039 ...... 43 CERH-010 ...... 117 CERM-015 ...... 130 CERB-022 ...... 90 CERD-016 ...... 102 CERE-040 ...... 42 CERH-013 ...... 115 CERM-016 ...... 130 CERB-023 ...... 90 CERD-017 ...... 107 CERE-041 ...... 43 CERH-017 ...... 118 CERM-017 ...... 136 CERB-024 ...... 91 CERD-019 ...... 105 CERE-042 ...... 42 CERH-026 ...... 120 CERM-018 ...... 136 CERB-026 ...... 90 CERD-021 ...... 105 CERE-043 ...... 42 CERH-027 ...... 120 CERM-019 ...... 129 CERB-030 ...... 91 CERD-023 ...... 103 CERE-044 ...... 43 CERH-030 ...... 115 CERM-020 ...... 130 CERB-032 ...... 92, 114 CERD-028 ...... 104 CERE-045 ...... 43 CERH-036 ...... 115 CERM-021 ...... 129 CERB-034 ...... 91 CERD-029 ...... 105 CERE-048 ...... 50, 111 CERH-037 ...... 115 CERM-022 ...... 129

Edition 2011/2012 LGC Standards – Excellence through measurement 233

Code number index

CERM-023 ...... 130 CERN-012 ...... 143 CERP-055 ...... 151 CERT-907 ...... 156 LGCFOR0007.08 . 63, 105 CERM-024 ...... 130 CERN-013 ...... 142 CERP-056 ...... 153 CERT-908 ...... 159 LGCFOR0007.11 . 74, 159 CERM-027 ...... 127 CERN-017 ...... 142 CERP-061 ...... 148 CERT-909 ...... 120 LGCFOR0011.00 . 65, 116 CERM-029 ...... 127 CERN-020 ...... 142 CERP-062 ...... 149 CERT-910 ...... 159 LGCFOR0013.00 ... 58, 88 CERM-030 ...... 135 CERN-022 ...... 139 CERP-063 ...... 150 CERT-911 ...... 120 LGCFOR0014.00 . 65, 114 CERM-031 ...... 136 CERN-030 ...... 141 CERP-072 ...... 151 CERT-912 ...... 156 LGCFOR0015.01 ... 60, 94 CERM-034 ...... 130 CERN-031 ...... 141 CERP-075 ...... 151 CERT-915 ...... 120 LGCFOR0017.00 ... 59, 94 CERM-035 ...... 128 CERN-032 ...... 142 CERP-076 ...... 152 CERT-916 ...... 120 LGCFOR0019.00 . 67, 124 CERM-036 ...... 128 CERN-034 ...... 140 CERP-077 ...... 152 CERT-920 ...... 159 LGCFOR0019.01 . 67, 124 CERM-038 ...... 128 CERN-036 ...... 141 CERP-078 ...... 149 CERV-002 ...... 160 LGCFOR0019.07 . 62, 102 CERM-039 ...... 128 CERN-037 ...... 142 CERP-080 ...... 148 CERV-004 ...... 160 LGCFOR0022.00 . 75, 160 CERM-041 ...... 131 CERN-038 ...... 137 CERP-901 ...... 152 CERV-006 ...... 160 LGCFOR0023.00 . 63, 104 CERM-045 ...... 132 CERN-042 ...... 138 CERP-902 ...... 152 CERV-009 ...... 160 LGCFOR0023.02 . 70, 140 CERM-046 ...... 137 CERN-043 ...... 141 CERP-903 ...... 152 CERW-003 ...... 161 LGCFOR0027.00 . 68, 134 CERM-047 ...... 128 CERN-045 ...... 139 CERP-904 ...... 152 CERZ-001 ...... 161 LGCFOR0028.02 ...... 99 CERM-051 ...... 128 CERN-046 ...... 93, 143 CERP-905 ...... 151 CERZ-002 ...... 161 LGCFOR0028.03 ... 57, 84 CERM-055 ...... 131 CERN-047 ...... 138 CERP-906 ...... 151 CERZ-003 ...... 161 LGCFOR0032.00 . 64, 107 CERM-059 ...... 130 CERN-048 ...... 138 CERP-909 ...... 82, 147 CERZ-901 ...... 161 LGCFOR0033.00 . 62, 103 CERM-060 ...... 130 CERN-049 ...... 143 CERP-910 ...... 151 DTI-600-1 ...... 13 LGCFOR0033.09 . 61, 101 CERM-061 ...... 131 CERN-051 ...... 137 CERP-913 ...... 152 DTI-600-2 ...... 13 LGCFOR0033.10 . 61, 101 CERM-065 ...... 127 CERN-055 ...... 141 CERP-914 ...... 152 DTI-710 ...... 13 LGCFOR0037.00 . 69, 135 CERM-067 ...... 127 CERN-057 ...... 139 CERP-915 ...... 147 DTI-766 ...... 13 LGCFOR0038.00 ... 59, 95 CERM-068 ...... 127 CERN-059 ...... 139 CERP-916 ...... 147 EJ-191-0631 ...... 155 LGCFOR0042.00 . 71, 147 CERM-074 ...... 128 CERN-061 ...... 143 CERP-917 ...... 82, 147 EJ-O139-0121...... 144 LGCFOR0043.00 . 72, 151 CERM-077 ...... 162 CERN-062 ...... 143 CERQ-001...... 153 EJ-Q646-0311...... 153 LGCFOR0045.00 . 73, 154 CERM-078 ...... 162 CERN-063 ...... 137 CERR-002 ...... 153 ERM-AC200 ...... 14 LGCFOR0051.00 . 73, 155 CERM-079 ...... 131 CERN-067 ...... 138 CERR-006 ...... 154 ERM-AC401 ...... 41 LGCFOR0051.05 . 68, 131 CERM-080 ...... 133, 211 CERN-068 ...... 199 CERR-013 ...... 154 ERM-AC402 ...... 41 LGCFOR0051.07 . 62, 103 CERM-081 ...... 127 CERN-901 ...... 139 CERR-014 ...... 154 ERM-AC403 ...... 41 LGCFOR0052.00 . 67, 129 CERM-082 ...... 127 CERN-902 ...... 144 CERS-001 ...... 154 ERM-AC404 ...... 41 LGCFOR0056.00 . 67, 129 CERM-083 ...... 133 CERN-903 ...... 141 CERS-002 ...... 154 ERM-AC405 ...... 41 LGCFOR0056.04 . 67, 127 CERM-084 ...... 135 CERN-904 ...... 143 CERS-003 ...... 154 ERM-AC406 ...... 41 LGCFOR0059.06 . 70, 143 CERM-085 ...... 136 CERN-905 ...... 141 CERS-004 ...... 154 ERM-AC407 ...... 41 LGCFOR0060.00 ... 59, 90 CERM-086 ...... 136 CERN-906 ...... 138 CERS-008 ...... 155 ERM-AC409 ...... 41 LGCFOR0060.16 . 61, 101 CERM-088 ...... 129 CERN-907 ...... 144 CERS-010 ...... 155 ERM-AC510 ...... 41 LGCFOR0061.00 ... 57, 83 CERM-089 ...... 129 CERN-911 ...... 141 CERS-015 ...... 155 ERM-AC511 ...... 41 LGCFOR0062.00 ... 57, 85 CERM-090 ...... 130 CERN-912 ...... 139 CERS-018 ...... 155 ERM-AC803 ...... 14 LGCFOR0062.05 . 66, 117 CERM-091 ...... 130 CERN-913 ...... 143 CERS-019 ...... 154 ERM-AD148 ...... 14 LGCFOR0064.00 ... 58, 90 CERM-092 ...... 130 CERN-914 ...... 205 CERS-021 ...... 155 ERM-AD149 ...... 14 LGCFOR0068.00 . 63, 106 CERM-093 ...... 130 CERN-919 ...... 143 CERS-025 ...... 122 ERM-AD452 ...... 17 LGCFOR0068.03 . 62, 102 CERM-094 ...... 127 CERN-920 ...... 139 CERS-026 ...... 155 ERM-AD453 ...... 17 LGCFOR0068.05 . 61, 100 CERM-095 ...... 127 CERN-921 ...... 139 CERS-027 ...... 122 ERM-AD454 ...... 16 LGCFOR0069.00 . 65, 112 CERM-096 ...... 136 CERN-922 ...... 141 CERS-037 ...... 122 ERM-AD455 ...... 17 LGCFOR0069.02 . 62, 102 CERM-102 ...... 126 CERN-923 ...... 141 CERS-903 ...... 207 ERM-AD457/IFCC ...... 17 LGCFOR0070.02 . 61, 100 CERM-103 ...... 135 CERO-002 ...... 145 CERS-906 ...... 207 ERM-CE195 ...... 22, 26 LGCFOR0071.00 . 67, 125 CERM-104 ...... 126 CERO-003 ...... 146 CERT-002 ...... 162 ERM-CE196 ...... 22, 27 LGCFOR0071.01 ...... 57 CERM-105 ...... 133 CERO-004 ...... 146 CERT-003 ...... 157 ERM-DA120 ...... 28 LGCFOR0071.04 ... 59, 94 CERM-106 ...... 137 CERO-005 ...... 145 CERT-004 ...... 139 ERM-DA192 ...... 24 LGCFOR0071.09 ... 59, 94 CERM-107 ...... 84 CERO-006 ...... 146 CERT-005 ...... 157 ERM-DA193 ...... 24 LGCFOR0076.00 ... 59, 93 CERM-108 ...... 137 CERO-007 ...... 146 CERT-006 ...... 139 ERM-DA200 ...... 15 LGCFOR0076.01 ... 59, 93 CERM-120 ...... 137 CERO-008 ...... 146 CERT-007 ...... 140 ERM-DA250 ...... 19 LGCFOR0076.06 . 66, 121 CERM-123 ...... 134 CERO-013 ...... 126, 145 CERT-008 ...... 140 ERM-DA251 ...... 20 LGCFOR0076.10 . 66, 118 CERM-127 ...... 134 CERO-019 ...... 146 CERT-013 ...... 157 ERM-DA252 ...... 20 LGCFOR0076.17 . 70, 145 CERM-128 ...... 135 CERO-021 ...... 144 CERT-014 ...... 159 ERM-DA253 ...... 20 LGCFOR0077.00 . 66, 121 CERM-129 ...... 133 CERO-023 ...... 145 CERT-018 ...... 140 ERM-DA345 ...... 24 LGCFOR0077.04 . 66, 119 CERM-131 ...... 128 CERO-024 ...... 144 CERT-019 ...... 140 ERM-DA346 ...... 24 LGCFOR0077.12 . 66, 121 CERM-135 ...... 137 CERO-025 ...... 145 CERT-020 ...... 158 ERM-DA347 ...... 24 LGCFOR0078.00 . 69, 138 CERM-136 ...... 131 CERO-032 ...... 144 CERT-021 ...... 162 ERM-DA451 ...... 24 LGCFOR0078.01 ... 57, 85 CERM-137 ...... 137 CERO-035 ...... 144 CERT-022 ...... 162 ERM-DA470K/IFCC ..... 32 LGCFOR0078.07 ... 57, 85 CERM-138 ...... 128 CERO-901 ...... 145 CERT-027 ...... 159 ERM-DA471K/IFCC ..... 32 LGCFOR0079.00 . 70, 144 CERM-139 ...... 128 CERO-902 ...... 144 CERT-029 ...... 158 ERM-DA472/IFCC ...... 32 LGCFOR0080.00 . 70, 144 CERM-140 ...... 133 CERO-904 ...... 145 CERT-030 ...... 159 HEC JCCLS021 ...... 21 LGCFOR0086.00 . 72, 153 CERM-141 ...... 133 CERP-003 ...... 148 CERT-032 ...... 157 HEC JCCRM111 ...... 16 LGCFOR0090.00 ... 60, 94 CERM-142 ...... 135 CERP-004 ...... 149 CERT-033 ...... 157 HEC JCCRM211 ...... 19 LGCFOR0090.13 . 61, 101 CERM-143 ...... 129 CERP-006 ...... 148 CERT-034 ...... 201 HEC JCCRM223 ...... 21 LGCFOR0091.00 . 74, 157 CERM-145 ...... 135 CERP-007 ...... 148 CERT-035 ...... 103 HEC JCCRM521 ...... 21 LGCFOR0091.03 . 70, 143 CERM-146 ...... 133 CERP-008 ...... 149 CERT-036 ...... 158 HEC JCERM20327 ...... 17 LGCFOR0094.00 ... 58, 88 CERM-147 ...... 131 CERP-009 ...... 147 CERT-037 ...... 211 HEC JDS2 ...... 30 LGCFOR0095.00 . 70, 146 CERM-148 ...... 199 CERP-010 ...... 147 CERT-038 ...... 140 IRMM/IFCC 456 ...... 16 LGCFOR0099.00 ...... 71 CERM-901 ...... 134 CERP-011 ...... 152 CERT-039 ...... 158 IRMM/IFCC-467 ...... 31 LGCFOR0099.01 . 71, 147 CERM-906 ...... 203 CERP-013 ...... 147 CERT-041 ...... 158 IRMM/IFCC-490 ...... 177 LGCFOR0101.00 . 64, 107 CERM-908 ...... 134 CERP-017 ...... 149 CERT-045 ...... 159 IRMM/IFCC-491 ...... 178 LGCFOR0102.00 . 67, 124 CERM-910 ...... 131, 202 CERP-018 ...... 149 CERT-049 ...... 156 IRMM/IFCC-492 ...... 178 LGCFOR0107.00 . 64, 107 CERM-912 ...... 130, 202 CERP-019 ...... 149 CERT-050 ...... 156 IRMM-468 ...... 24 LGCFOR0114.00 . 65, 113 CERM-914 ...... 203 CERP-021 ...... 149 CERT-058 ...... 156 IRMM-469 ...... 24 LGCFOR0128.00 ... 59, 93 CERM-916 ...... 203 CERP-023 ...... 149 CERT-060 ...... 156 LA 30-1400-1 ...... 50 LGCFOR0129.00 . 70, 146 CERM-918 ...... 135 CERP-035 ...... 153 CERT-061 ...... 156 LA 30-1600-1 ...... 50 LGCFOR0130.00 . 64, 110 CERM-919 ...... 134 CERP-036 ...... 153 CERT-062 ...... 158 LA 30-1800-1 ...... 50 LGCFOR0133.00 ... 57, 83 CERM-920 ...... 126 CERP-037 ...... 162 CERT-067 ...... 156 LA 30-1801-1 ...... 50 LGCFOR0134.00 . 74, 158 CERN-003 ...... 140 CERP-038 ...... 150 CERT-068 ...... 158 LGC7330 ...... 22 LGCFOR0134.05 . 74, 158 CERN-004 ...... 137 CERP-044 ...... 151 CERT-070 ...... 211 LGCFOR0002.00 . 66, 121 LGCFOR0144.00 . 66, 123 CERN-005 ...... 140 CERP-045 ...... 148 CERT-072 ...... 156 LGCFOR0004.05 . 70, 140 LGCFOR0147.00 . 69, 134 CERN-006 ...... 142 CERP-048 ...... 153 CERT-902 ...... 156 LGCFOR0006.00 . 63, 104 LGCFOR0147.06 . 69, 134 CERN-007 ...... 138 CERP-049 ...... 153 CERT-903 ...... 160 LGCFOR0007.00 . 74, 158 LGCFOR0149.00 . 75, 161 CERN-008 ...... 138 CERP-050 ...... 150 CERT-904 ...... 160 LGCFOR0007.04 ... 58, 87 LGCFOR0149.01 . 75, 161 CERN-011 ...... 142 CERP-051 ...... 150 CERT-905 ...... 158 LGCFOR0007.06 . 62, 103 LGCFOR0152.00 . 69, 138

234 LGC Standards – Excellence through measurement Edition 2011/2012

Code number index

LGCFOR0157.01 . 71, 148 LGCFOR0596.00 72, 151 LGCFOR1275.57 .71, 147 ME 20133 ...... 44 ME 91311 ...... 45 LGCFOR0171.01 ... 57, 84 LGCFOR0599.00 63, 106 LGCFOR1275.59 .74, 158 ME 20150 ...... 44 ME 91321 ...... 46 LGCFOR0176.00 . 74, 157 LGCFOR0601.03 74, 160 LGCFOR1275.60 .68, 132 ME 20151 ...... 44 ME 91331 ...... 46 LGCFOR0180.00 . 67, 123 LGCFOR0608.00 64, 111 LGCFOR1275.61 .68, 132 ME 20153 ...... 44 ME 91341 ...... 46 LGCFOR0180.04 . 67, 123 LGCFOR0608.01 70, 141 LGCFOR1275.62 .68, 134 ME 20200 ...... 44 ME 91351 ...... 46 LGCFOR0185.00 . 65, 117 LGCFOR0614.02 .. 57, 83 LGCFOR1275.63 .64, 111 ME 20201 ...... 44 ME 91361 ...... 46 LGCFOR0185.08 . 60, 100 LGCFOR0630.00 72, 150 LGCFOR1275.64 .65, 113 ME 20203 ...... 44 ME 91371 ...... 46 LGCFOR0212.00 . 63, 105 LGCFOR0651.00 62, 150 LGCFOR1275.65 .68, 131 ME 20300 ...... 45 NCS ZC76009 ...... 19 LGCFOR0214.00 ... 60, 98 LGCFOR0652.00 64, 109 LGCFOR1275.66 .66, 122 ME 20301 ...... 44 NCS ZC76020B ...... 18 LGCFOR0222.00 . 72, 151 LGCFOR0656.00 71, 150 LGCFOR1275.70 .66, 123 ME 20303 ...... 45 NCS ZC84010 ...... 27 LGCFOR0233.00 . 69, 138 LGCFOR0660.00 69, 138 LGCFOR1275.71 .. 57, 82 ME 20400 ...... 45 NCS ZC84011 ...... 27 LGCFOR0240.00 . 74, 160 LGCFOR0660.01 70, 139 LGCFOR1275.72 .66, 121 ME 20401 ...... 45 NCSZC81002B ...... 30 LGCFOR0240.02 . 62, 103 LGCFOR0672.00 71, 145 LGCFOR1275.78 .66, 121 ME 20403 ...... 45 NIST-1400 ...... 29 LGCFOR0242.00 ... 60, 95 LGCFOR0672.03 70, 142 LGCFOR1275.80 .67, 127 ME 20500 ...... 45 NIST-1486 ...... 30 LGCFOR0242.09 . 61, 101 LGCFOR0682.00 .. 60, 96 LGCFOR1280.01 .68, 134 ME 20501 ...... 45 NIST-1507B ...... 184 LGCFOR0250.00 . 69, 135 LGCFOR0703.00 74, 157 LGCFOR1294.00 .64, 108 ME 20503 ...... 45 NIST-1508A ...... 183 LGCFOR0254.00 . 73, 155 LGCFOR0741.02 65, 112 LGCFOR2115.00 .72, 153 ME 40011 ...... 184 NIST-1511 ...... 194 LGCFOR0254.04 . 73, 155 LGCFOR0745.00 .. 59, 91 LGCFOR9887.01 ...... 190 ME 40012 ...... 184 NIST-1595 ...... 19 LGCFOR0254.08 . 62, 102 LGCFOR0750.00 64, 111 ME 11010 ...... 46 ME 40051 ...... 184 NIST-1599 ...... 14, 181 LGCFOR0254.09 . 73, 155 LGCFOR0764.00 66, 118 ME 11012 ...... 46 ME 40052 ...... 184 NIST-1847 ...... 42 LGCFOR0256.00 . 65, 113 LGCFOR0764.02 61, 100 ME 11013 ...... 46 ME 40053 ...... 184 NIST-1951B ...... 21 LGCFOR0257.00 . 67, 124 LGCFOR0770.00 72, 150 ME 11020 ...... 47 ME 40054 ...... 184 NIST-1952A ...... 19 LGCFOR0265.03 ... 58, 88 LGCFOR0815.00 71, 148 ME 11022 ...... 47 ME 40055 ...... 184 NIST-1955 ...... 21 LGCFOR0267.00 . 69, 135 LGCFOR0820.00 67, 126 ME 11023 ...... 47 ME 40056 ...... 184 NIST-1957 ...... 27 LGCFOR0272.00 . 69, 137 LGCFOR0826.00 71, 148 ME 11030 ...... 47 ME 40131 ...... 184 NIST-2372 ...... 176 LGCFOR0280.00 . 69, 135 LGCFOR0826.01 71, 148 ME 11032 ...... 47 ME 40132 ...... 184 NIST-2379 ...... 191 LGCFOR0282.00 . 64, 110 LGCFOR0828.00 71, 148 ME 11033 ...... 47 ME 40151 ...... 13 NIST-2380 ...... 191 LGCFOR0289.00 ... 58, 88 LGCFOR0852.00 66, 121 ME 11050 ...... 47 ME 40161 ...... 13 NIST-2381 ...... 186 LGCFOR0289.18 ...... 58 LGCFOR0863.00 73, 156 ME 11052 ...... 47 ME 40201 ...... 13 NIST-2382 ...... 186 LGCFOR0290.00 . 72, 151 LGCFOR0864.00 .. 58, 90 ME 11053 ...... 47 ME 40531 ...... 192 NIST-2389A ...... 18 LGCFOR0290.01 . 72, 151 LGCFOR0897.00 73, 157 ME 11080 ...... 47 ME 40532 ...... 192 NIST-2390 ...... 176 LGCFOR0300.00 . 64, 110 LGCFOR0922.00 67, 124 ME 11082 ...... 47 ME 40571 ...... 193 NIST-2391B ...... 177 LGCFOR0306.00 . 74, 159 LGCFOR0957.00 70, 146 ME 11083 ...... 47 ME 40572 ...... 193 NIST-2392 ...... 177 LGCFOR0317.00 . 73, 155 LGCFOR0958.00 74, 159 ME 11100 ...... 47 ME 41057 ...... 51 NIST-2392-I ...... 177 LGCFOR0317.01 . 73, 155 LGCFOR0959.00 65, 113 ME 11102 ...... 47 ME 41058 ...... 20, 51 NIST-2394 ...... 177 LGCFOR0323.00 . 73, 156 LGCFOR0964.00 67, 129 ME 11103 ...... 47 ME 41079 ...... 22, 51, 185 NIST-2395 ...... 177 LGCFOR0323.01 ... 58, 87 LGCFOR0983.00 .. 60, 96 ME 11110 ...... 47 ME 41080 ...... 51, 185 NIST-2396 ...... 177 LGCFOR0323.03 . 64, 110 LGCFOR0991.02 62, 102 ME 11112 ...... 47 ME 41081 ...... 22, 51, 185 NIST-2399 ...... 177 LGCFOR0380.01 ... 59, 94 LGCFOR0991.03 63, 104 ME 11113 ...... 47 ME 41217 ...... 182 NIST-2670A ...... 23, 29 LGCFOR0380.11 ... 59, 94 LGCFOR1001.06 69, 137 ME 11130 ...... 47 ME 41221 ...... 182 NIST-2672A ...... 23, 29 LGCFOR0380.13 ... 59, 93 LGCFOR1005.01 68, 133 ME 11132 ...... 47 ME 41222 ...... 182 NIST-2891 ...... 41 LGCFOR0381.00 . 73, 154 LGCFOR1005.07 68, 134 ME 11133 ...... 47 ME 41413 ...... 188 NIST-2892 ...... 41 LGCFOR0393.00 . 74, 160 LGCFOR1031.04 73, 154 ME 11150 ...... 47 ME 41414 ...... 188 NIST-2893 ...... 41 LGCFOR0393.01 . 62, 103 LGCFOR1035.00 67, 124 ME 11152 ...... 47 ME 41415 ...... 188 NIST-2894 ...... 42 LGCFOR0393.04 . 62, 103 LGCFOR1083.00 .. 60, 98 ME 11153 ...... 47 ME 41416 ...... 188 NIST-2895 ...... 42 LGCFOR0412.00 . 72, 151 LGCFOR1122.00 64, 108 ME 11200 ...... 47 ME 41430 ...... 188 NIST-2896 ...... 42 LGCFOR0412.04 . 72, 151 LGCFOR1147.00 64, 110 ME 11202 ...... 47 ME 41431 ...... 189 NIST-2897 ...... 42 LGCFOR0420.00 ... 60, 94 LGCFOR1247.02 68, 131 ME 11203 ...... 47 ME 41470 ...... 189 NIST-2898 ...... 42 LGCFOR0420.01 ... 60, 95 LGCFOR1275.01 68, 133 ME 11300 ...... 47 ME 41471 ...... 189 NIST-2899 ...... 42 LGCFOR0421.00 . 74, 159 LGCFOR1275.02 ...... 111 ME 11302 ...... 47 ME 41472 ...... 189 NIST-2921 ...... 31 LGCFOR0422.01 . 61, 100 LGCFOR1275.03 .. 59, 92 ME 11303 ...... 47 ME 41652 ...... 191 NIST-2972 ...... 33 LGCFOR0435.02 . 63, 104 LGCFOR1275.04 67, 131 ME 11400 ...... 48 ME 41653 ...... 191 NIST-900 ...... 15, 181 LGCFOR0442.00 ... 60, 98 LGCFOR1275.05 68, 132 ME 11402 ...... 48 ME 41703 ...... 183 NIST-909C ...... 16 LGCFOR0456.00 ... 58, 88 LGCFOR1275.06 69, 138 ME 11403 ...... 48 ME 41704 ...... 183 NIST-911C ...... 18 LGCFOR0460.08 ... 58, 90 LGCFOR1275.07 68, 128 ME 11500 ...... 48 ME 42606 ...... 190 NIST-912A ...... 19 LGCFOR0467.00 ... 58, 87 LGCFOR1275.08 63, 106 ME 11502 ...... 48 ME 42916 ...... 189 NIST-913A ...... 19 LGCFOR0480.00 ... 60, 96 LGCFOR1275.12 63, 106 ME 11503 ...... 48 ME 42919 ...... 189 NIST-914A ...... 18 LGCFOR0480.03 . 61, 101 LGCFOR1275.13 65, 113 ME 12012 ...... 48 ME 42920 ...... 189 NIST-915b ...... 15 LGCFOR0490.00 . 63, 106 LGCFOR1275.16 . 59, 94, ME 12013 ...... 48 ME 42921 ...... 190 NIST-916A ...... 18 LGCFOR0490.01 . 63, 107 146 ME 12022 ...... 48 ME 42922 ...... 190 NIST-917C ...... 18 LGCFOR0490.02 ... 58, 88 LGCFOR1275.17 . 57, 84, ME 12023 ...... 48 ME 43303 ...... 185 NIST-918B ...... 15 LGCFOR0490.03 . 70, 141 113 ME 12032 ...... 48 ME 43304 ...... 185 NIST-919B ...... 15 LGCFOR0491.00 . 72, 154 LGCFOR1275.18 63, 104 ME 12033 ...... 48 ME 44103 ...... 187 NIST-921 ...... 23 LGCFOR0491.03 . 66, 119 LGCFOR1275.19 .. 59, 90 ME 20010 ...... 43 ME 44104 ...... 187 NIST-924A ...... 15 LGCFOR0493.00 . 73, 156 LGCFOR1275.20 68, 133 ME 20011 ...... 44 ME 44401 ...... 182 NIST-925 ...... 18 LGCFOR0494.00 ... 59, 92 LGCFOR1275.21 ...... 127 ME 20013 ...... 44 ME 44505 ...... 187 NIST-927D ...... 18 LGCFOR0510.00 . 64, 107 LGCFOR1275.22 62, 103 ME 20020 ...... 44 ME 61050 ...... 50 NIST-928 ...... 22 LGCFOR0517.00 . 69, 138 LGCFOR1275.23 .. 58, 87 ME 20021 ...... 44 ME 61052 ...... 50 NIST-929a ...... 15 LGCFOR0517.03 ... 60, 98 LGCFOR1275.24 .. 58, 87 ME 20023 ...... 44 ME 61053 ...... 50 NIST-937 ...... 22 LGCFOR0528.00 . 65, 112 LGCFOR1275.25 ...... 87 ME 20030 ...... 44 ME 61080 ...... 50 NIST-955C ...... 22, 26 LGCFOR0528.04 . 62, 150 LGCFOR1275.28 .. 57, 82 ME 20031 ...... 44 ME 61082 ...... 50 NIST-956C ...... 16 LGCFOR0528.08 72, 144, LGCFOR1275.29 .. 57, 82 ME 20033 ...... 44 ME 61083 ...... 50 NIST-965B ...... 20 150 LGCFOR1275.30 63, 106 ME 20050 ...... 44 ME 61110 ...... 50 NIST-966 ...... 25 LGCFOR0539.07 . 72, 150 LGCFOR1275.32 .. 59, 92 ME 20051 ...... 44 ME 61112 ...... 50 NIST-967A ...... 19 LGCFOR0542.00 . 72, 154 LGCFOR1275.33 65, 113 ME 20053 ...... 44 ME 61113 ...... 50 NIST-968D ...... 19, 33 LGCFOR0545.00 ... 60, 95 LGCFOR1275.35 69, 138 ME 20080 ...... 44 ME 70002 ...... 18, 50 NIST-970 ...... 33 LGCFOR0545.08 . 61, 101 LGCFOR1275.36 .. 58, 88 ME 20081 ...... 44 ME 70010 ...... 18, 50 NIST-972 ...... 33 LGCFOR0548.00 . 71, 149 LGCFOR1275.41 68, 132 ME 20083 ...... 44 ME 70502 ...... 18, 50 NIST-RM 8444 ..... 18, 28, LGCFOR0551.00 . 71, 148 LGCFOR1275.42 63, 106 ME 20100 ...... 44 ME 70510 ...... 18, 50 185 LGCFOR0557.00 . 64, 107 LGCFOR1275.43 65, 113 ME 20101 ...... 44 ME 91111 ...... 49 NMIAD283 ...... 208 LGCFOR0562.00 ... 58, 87 LGCFOR1275.44 68, 132 ME 20103 ...... 44 ME 91121 ...... 49 NMIAD396 ...... 90, 107 LGCFOR0565.00 ... 58, 87 LGCFOR1275.46 72, 150 ME 20110 ...... 44 ME 91131 ...... 49 NMIAD397 ...... 152 LGCFOR0577.00 . 74, 157 LGCFOR1275.47 71, 148 ME 20111 ...... 44 ME 91141 ...... 49 NMIAD408 ...... 136 LGCFOR0582.00 . 65, 115 LGCFOR1275.49 65, 116 ME 20113 ...... 44 ME 91151 ...... 49 NMIAD420 ...... 86 LGCFOR0586.07 . 68, 132 LGCFOR1275.50 .. 57, 85 ME 20130 ...... 44 ME 91161 ...... 49 NMIAD425B ...... 129 LGCFOR0589.00 . 61, 100 LGCFOR1275.51 65, 114 ME 20131 ...... 44 ME 91171 ...... 49 NMIAD443 ...... 128 LGCFOR1275.54 68, 134

Edition 2011/2012 LGC Standards – Excellence through measurement 235

Code number index

NMIAD445 ...... 82 NMIAD621 ...... 207 NMIAD822...... 154, 208 NMIAD929 ...... 93 THC-1216 ...... 122 NMIAD447 ...... 114 NMIAD622 ...... 200 NMIAD823...... 105 NMIAD930 ...... 206 THC-1218 ...... 125 NMIAD450A ...... 126 NMIAD624 ...... 199 NMIAD824...... 117 NMIAD931 ...... 198 THC-1220 ...... 122 NMIAD452 ...... 132 NMIAD626 ...... 209 NMIAD825...... 205 NMIAD932 ...... 90 THC-1240 ...... 99 NMIAD453 ...... 106 NMIAD628 ...... 198 NMIAD826...... 97 NMIAD935 ...... 198 THC-1243 ...... 122 NMIAD455 ...... 90 NMIAD629 ...... 199 NMIAD827...... 125 NMIAD937 ...... 133 THC-1244 ...... 122 NMIAD456 ...... 89 NMIAD630 ...... 202 NMIAD829...... 209 NMIAD938 ...... 111 THC-1274-M ...... 160 NMIAD465 ...... 114 NMIAD634 ...... 209 NMIAD830...... 132 NMIAD939 ...... 208 THC-1276-10 ...... 160 NMIAD468 ...... 95 NMIAD635 ...... 209 NMIAD831...... 144 NMIAD940 ...... 208 THC-1276-M ...... 160 NMIAD470 ...... 106 NMIAD636 ...... 209 NMIAD832...... 213 NMIAD941 ...... 206 THC-1278M ...... 123 NMIAD495 ...... 152 NMIAD637 ...... 209 NMIAD833...... 213 NMIAD942 ...... 132 THC-1284M ...... 92 NMIAD498 ...... 114 NMIAD638 ...... 202 NMIAD834...... 213 NMIAD947 ...... 113 THC-1298-5 ...... 157 NMIAD500 ...... 208 NMIAD639 ...... 202 NMIAD841...... 204 NMIAD948 ...... 92 THC-1298M ...... 157 NMIAD502 ...... 114 NMIAD640 ...... 207 NMIAD842...... 127 NMIAD951 ...... 133 THC-1359-M ...... 84 NMIAD503 ...... 106 NMIAD641 ...... 207 NMIAD843...... 213 NMIAD952 ...... 131 THC-1372M ...... 84 NMIAD505 ...... 211 NMIAD642 ...... 207 NMIAD844...... 213 NMIAD954 ...... 131 THC-1373M ...... 123 NMIAD506 ...... 211 NMIAD644 ...... 211 NMIAD845...... 198, 213 NMIAD955 ...... 122 THC-1374M ...... 153 NMIAD507 ...... 211 NMIAD645 ...... 206 NMIAD846...... 160 NMIAD960 ...... 132 THC-1375M ...... 153 NMIAD508 ...... 211 NMIAD646 ...... 207 NMIAD847...... 87 NMIAD964 ...... 134 THC-167 ...... 135 NMIAD512 ...... 92 NMIAD669 ...... 132 NMIAD849...... 213 NMIAM243 ...... 133 TRC-0415002 ...... 144 NMIAD525 ...... 134 NMIAD671 ...... 97 NMIAD851...... 201 NMIAM296 ...... 141, 208 TRC-A105000 ...... 82, 175 NMIAD526 ...... 114 NMIAD673 ...... 97 NMIAD852...... 201 NMIAM297 ... 93, 143, 208 TRC-A105002 ...... 175 NMIAD528 ...... 211 NMIAD674 ...... 106 NMIAD853...... 201 NMIAM299 ...... 208 TRC-A105010 ...... 175 NMIAD529 ...... 212 NMIAD675 ...... 105 NMIAD854...... 112 NMIAM394 ...... 152, 212 TRC-A511450 ...... 174 NMIAD538 ...... 114 NMIAD678 ...... 209 NMIAD855...... 160 NMIAM558 ...... 212 TRC-A511452 ...... 174 NMIAD539 ...... 150 NMIAD679 ...... 203 NMIAD856...... 140 NMIAM605 ...... 159, 212 TRC-A628917 ...... 175 NMIAD543 ...... 111, 208 NMIAD680 ...... 210 NMIAD857...... 114 NMIAM642 ...... 212 TRC-A632950 ...... 85 NMIAD546 ...... 211 NMIAD683 ...... 211 NMIAD858...... 160 NMIAM647 ...... 212 TRC-A632952 ...... 85 NMIAD547 ...... 210 NMIAD684 ...... 204 NMIAD859...... 152 NMIAM723 ...... 109 TRC-A633250 ...... 85 NMIAD548 ...... 210 NMIAD686 ...... 123 NMIAD860...... 208 NMIAM724 ...... 92 TRC-A633252 ...... 85 NMIAD549 ...... 209 NMIAD687 ...... 134 NMIAD861...... 204 NMIAM880 ...... 110, 212 TRC-A634400 ...... 87, 175 NMIAD550 ...... 209 NMIAD688 ...... 211 NMIAD862...... 198 NMIAM898 ...... 208 TRC-A634402 ...... 87, 175 NMIAD551 ...... 210 NMIAD692 ...... 95 NMIAD863...... 159 NMIAM904 ...... 208 TRC-A790051 ...... 88, 175 NMIAD552 ...... 210 NMIAD693 ...... 106 NMIAD864...... 160 NMIAM914 ...... 211 TRC-A790052 ...... 88, 175 NMIAD554 ...... 204 NMIAD694 ...... 98 NMIAD865...... 213 NMIAM924 ...... 109 TRC-A825000 ...... 176 NMIAD555 ...... 204 NMIAD695 ...... 98 NMIAD866...... 214 NMIAM937 ...... 143 TRC-A825002 ...... 176 NMIAD556 ...... 201 NMIAD697 ...... 83 NMIAD867...... 214 NMIAM954 ...... 200 TRC-B276580 ...... 89 NMIAD557 ...... 202 NMIAD698 ...... 140 NMIAD868...... 89 NMIAM955 ...... 206 TRC-B276582 ...... 89 NMIAD558 ...... 205 NMIAD699 ...... 104 NMIAD869...... 149 NMIAMX002 ...... 212 TRC-B288612 ...... 89 NMIAD559 ...... 205 NMIAD700 ...... 137 NMIAD870...... 150 NMIAMX003 ...... 212 TRC-B684210 ...... 90 NMIAD560 ...... 203 NMIAD701 ...... 142 NMIAD871...... 208 NMIAMX005 ...... 212 TRC-B689450 ...... 90 NMIAD561 ...... 203 NMIAD704 ...... 83 NMIAD872...... 208 NMIAMX006 ...... 212 TRC-B690272 ...... 174 NMIAD562 ...... 202 NMIAD708 ...... 209 NMIAD873...... 214 NMIAP1787 ...... 201 TRC-B690273 ...... 174 NMIAD563 ...... 199 NMIAD709 ...... 136 NMIAD875...... 213 NMIAP1795 ...... 201 TRC-C125700 ...... 33 NMIAD564 ...... 198 NMIAD715 ...... 157 NMIAD878...... 206 NMIAP1796 ...... 201 TRC-C125702 ...... 34 NMIAD565 ...... 202 NMIAD721 ...... 206 NMIAD879...... 132 NMIAP1801 ...... 201 TRC-C144500 ...... 34 NMIAD567 ...... 199 NMIAD722 ...... 203 NMIAD880...... 132 NMIAP1802 ...... 201 TRC-C144502 ...... 34 NMIAD571 ...... 200 NMIAD724 ...... 131 NMIAD881...... 150 NMIJ CRM6001-9 ...... 18 TRC-C225702 ...... 93 NMIAD572 ...... 209 NMIAD726 ...... 153 NMIAD882...... 112 RCG-375-1ML...... 121 TRC-C379965 ...... 94 NMIAD573 ...... 210 NMIAD731B ...... 157 NMIAD883...... 133 RCG-377-1ML...... 122 TRC-C587502 ...... 96 NMIAD574 ...... 210 NMIAD734 ...... 146 NMIAD884...... 115 RCG-377-50MG ...... 122 TRC-C781502 ...... 99 NMIAD576 ...... 202 NMIAD738 ...... 82 NMIAD885...... 106 RCG-380-10MG ...... 123 TRC-D193500 ..... 99, 175 NMIAD577 ...... 206 NMIAD739 ...... 127 NMIAD886...... 213 RCG-381-10MG ...... 122 TRC-D193502 ..... 99, 175 NMIAD580 ...... 209 NMIAD742 ...... 205 NMIAD887...... 133 REC-21014 ...... 51, 184 TRC-D230625 ..... 99, 175 NMIAD581 ...... 198 NMIAD743 ...... 147 NMIAD890...... 132 REC-21080 ...... 50 TRC-D230630 ..... 99, 175 NMIAD582 ...... 198 NMIAD745 ...... 89 NMIAD891...... 207 REC-21081 ...... 50 TRC-D288690 ...... 175 NMIAD583 ...... 203 NMIAD746 ...... 108 NMIAD892...... 145, 208 REC-21082 ...... 51 TRC-D288735 ...... 100 NMIAD584A ...... 204 NMIAD747 ...... 97 NMIAD893...... 207 SERO100205 ...... 21 TRC-D288790 ...... 174 NMIAD587 ...... 210 NMIAD748 ...... 148 NMIAD894...... 159 SERO101405 ...... 188 TRC-D292145 ...... 102 NMIAD590 ...... 210 NMIAD749 ...... 106 NMIAD895...... 132, 208 SERO101505 ...... 188 TRC-D297430 ...... 175 NMIAD591 ...... 210 NMIAD750 ...... 147 NMIAD896...... 132 SERO200905 ...... 31 TRC-D297450 ...... 175 NMIAD593 ...... 209 NMIAD752 ...... 115 NMIAD898...... 204 SERO201205 ...... 29, 37 TRC-D440950 ...... 175 NMIAD594 ...... 209 NMIAD753 ...... 110 NMIAD899...... 131 SERO201405 ...... 28, 36 TRC-D440952 ...... 175 NMIAD595a ...... 205 NMIAD756 ...... 150 NMIAD903...... 133 SERO202805 ...... 31 TRC-D440960 ...... 104 NMIAD596a ...... 204 NMIAD758 ...... 90 NMIAD904...... 203 SERO202905 ...... 31 TRC-D444785 ...... 105 NMIAD597 ...... 202 NMIAD766 ...... 135 NMIAD905...... 89 SERO203005 ...... 34 TRC-D444787 ...... 105 NMIAD598 ...... 202 NMIAD767 ...... 208 NMIAD906...... 159 SERO203105 ...... 28, 37 TRC-E425000 .... 109, 175 NMIAD599 ...... 201 NMIAD768 ...... 128 NMIAD907...... 94 SERO203405 ...... 34 TRC-E425002 .... 109, 175 NMIAD601 ...... 199 NMIAD775 ...... 153 NMIAD908...... 150 SERO206005 ...... 34 TRC-E425005 ...... 175 NMIAD602 ...... 200 NMIAD777 ...... 135 NMIAD909.. 198, 201, 208 SERO206105 ...... 34 TRC-E525000 .... 109, 175 NMIAD603 ...... 210 NMIAD778 ...... 160 NMIAD910...... 200 SERO206205 ...... 34 TRC-E525002 .... 109, 175 NMIAD604 ...... 210 NMIAD781 ...... 149 NMIAD912...... 144, 208 SERO207005 ...... 34 TRC-E555600 ...... 175 NMIAD605 ...... 210 NMIAD782 ...... 204 NMIAD913...... 207 SERO207205 ...... 34 TRC-E558902 ...... 175 NMIAD606 ...... 211 NMIAD783 ...... 203 NMIAD914...... 207 SERO210105 ...... 25, 35 TRC-E925182 ...... 50 NMIAD607 ...... 211 NMIAD785 ...... 116 NMIAD915...... 207 SERO210205 ...... 26, 35 TRC-E925327 ...... 50 NMIAD608 ...... 211 NMIAD791 ...... 146 NMIAD916...... 203 SERO210305 ...... 26, 36 TRC-E925340 ...... 111 NMIAD609 ...... 210 NMIAD792C ...... 127 NMIAD917...... 149 THC-004 ...... 157 TRC-E925342 ...... 111 NMIAD610 ...... 209 NMIAD796 ...... 206 NMIAD918...... 112 THC-1073M ...... 92 TRC-E925482 ...... 50 NMIAD613 ...... 205 NMIAD809 ...... 204 NMIAD919...... 106 THC-1137A ...... 153 TRC-E925952 ...... 50 NMIAD614 ...... 198 NMIAD810 ...... 132 NMIAD920...... 199 THC-1185 ...... 122 TRC-E937000 ...... 175 NMIAD615 ...... 205 NMIAD811 ...... 198 NMIAD921...... 200, 206 THC-1185M ...... 122 TRC-E937002 ...... 175 NMIAD616 ...... 200 NMIAD812 ...... 114 NMIAD922...... 106 THC-1186 ...... 99 TRC-E937003 ...... 175 NMIAD617 ...... 200 NMIAD816 ...... 132 NMIAD923...... 131 THC-1187 ...... 99 TRC-F274990 ...... 112 NMIAD618 ...... 199 NMIAD818 ...... 205 NMIAD924...... 132 THC-1213 ...... 122 TRC-F335002 ...... 175 NMIAD619 ...... 202 NMIAD820 ...... 205 NMIAD926...... 32, 205 THC-1214 ...... 123 TRC-F421000 ...... 174 NMIAD620 ...... 206 NMIAD821 ...... 82 NMIAD928...... 203 THC-1215 ...... 122 TRC-F421002 ...... 174

236 LGC Standards – Excellence through measurement Edition 2011/2012

TRC-F588480 ...... 112 TRC-I525002 ...... 175 TRC-M303962...... 132 TRC-Q694010 ...... 153 TRC-T018502 .... 156, 176 TRC-F588482 ...... 112 TRC-I525006 ...... 121 TRC-M304080...... 132 TRC-Q694012 ...... 153 TRC-T018510 .... 156, 176 TRC-F597950 ...... 113 TRC-I937500 ...... 174 TRC-M304082...... 133 TRC-Q694015 ...... 153 TRC-T345600 ...... 157 TRC-F597960 ...... 113 TRC-I937502 ...... 174 TRC-M305310...... 126 TRC-R100300 ...... 175 TRC-T345602 ...... 158 TRC-F598000 ...... 113 TRC-K186000 ...... 174 TRC-M305312...... 126 TRC-R100302 ...... 175 TRC-T412000 ...... 176 TRC-F598010 ...... 113 TRC-K186002 ...... 174 TRC-M325963...... 175 TRC-R100310 ...... 175 TRC-T412002 ...... 176 TRC-F727250 ...... 114 TRC-K195000 ...... 174 TRC-M330725...... 134 TRC-R142000 ...... 153 TRC-T412003 ...... 176 TRC-H297400...... 122 TRC-L172500 .... 123, 175 TRC-M330730...... 134 TRC-R142002 ...... 153 TRC-T412152 ...... 176 TRC-H916900...... 118 TRC-L172502 .... 123, 175 TRC-M342000...... 211 TRC-R414475 ...... 176 TRC-T444900 ...... 157 TRC-H924500...... 118 TRC-L174500 ...... 174 TRC-N389750 .... 138, 175 TRC-R414477 ...... 176 TRC-T444902 .... 157, 176 TRC-H924510...... 118 TRC-L174502 ...... 174 TRC-N389752 .... 138, 175 TRC-R414500 ...... 176 TRC-T444910 ...... 176 TRC-H941820...... 175 TRC-L331500 ...... 124 TRC-N389760 ...... 138 TRC-R517000 ...... 176 TRC-T444912 ...... 176 TRC-H941825.... 118, 175 TRC-L469480 .... 124, 175 TRC-N391275 .... 138, 175 TRC-R517002 ...... 176 TRC-V760000 ...... 174 TRC-H941827...... 118 TRC-L469482 .... 124, 175 TRC-N391277 .... 138, 175 TRC-R525002 ...... 154 TRC-V760002 ...... 174 TRC-H942400...... 119 TRC-L469485 .... 124, 175 TRC-O415000 ...... 144 TRC-R535000 .... 154, 176 TRC-V760010 ...... 174 TRC-H942402...... 119 TRC-L469490 .... 124, 175 TRC-O695300 ...... 144 TRC-R535002 .... 154, 176 TRC-V760012 ...... 174 TRC-H943600...... 174 TRC-M193000 ...... 175 TRC-O695302 ...... 144 TRC-R535003 .... 154, 176 TRC-Z140000 ...... 161 TRC-H943602...... 174 TRC-M193002 ...... 175 TRC-O846800 ...... 174 TRC-R701700 ...... 176 TRC-Z145000 ...... 161 TRC-H943603...... 174 TRC-M205502 ...... 126 TRC-P283652 ...... 122 TRC-S088127 ...... 154 TRC-Z145002 ...... 161 TRC-H948625...... 119 TRC-M224202 ...... 133 TRC-P681000 ...... 175 TRC-S135000 .... 154, 176 TRC-Z148000 ...... 176 TRC-H953225...... 119 TRC-M225620 ...... 126 TRC-P689600 ...... 174 TRC-S135002 .... 154, 176 TRC-Z148002 ...... 176 TRC-H953227...... 119 TRC-M225925 ...... 130 TRC-P689602 ...... 174 TRC-S685250 ...... 155 TRC-H995820...... 33 TRC-M225927 ...... 131 TRC-P755800 ...... 151 TRC-S685252 ...... 155 TRC-I465200 ...... 121 TRC-M260150 ...... 131 TRC-Q510000 ...... 153 TRC-T016000 ...... 176 TRC-I525000 ..... 121, 175 TRC-M260152 ...... 131 TRC-Q694000 ...... 153 TRC-T018500 .... 156, 176

Edition 2011/2012 LGC Standards – Excellence through measurement 237

Product index

N-(2-Aminoethyl)-2- Congener alcohols in serum ...... 46 Product index (benzylphenylamino)acetamide DiHCl 57, Congener alcohols in serum ...... 46 84 7-(Triethylsil)-10-Deacetylbaccatin-III ..... 170 Congener alcohols in serum ...... 46 7-Aminoflunitrazepam ...... 84 5beta-Androst-1-en-17beta-ol-3-one Congener alcohols in serum ...... 46 glucuronide, ...... 198 7-Aminoflunitrazepam ...... 85 Congener alcohols in serum ...... 46 a-Amyrin ...... 168 7-Aminoflunitrazepam-D7 ...... 85 Aqueous ethanol 107 mg / 100mL ...... 41 AB-001 ...... 57, 82 2-Aminoindane Hydrochloride (2-AI HCl) .57 , Aqueous ethanol 200 mg / 100 mL ...... 41 85 Abacavir 5-beta-D-glucuronide...... 175 Aqueous ethanol ...... 41 7-Aminonitrazepam ...... 85 Abacavir sulfate ...... 82, 175 Aqueous ethanol 80mg / 100 mL ...... 41 7-Aminonitrazepam ...... 85 Abacavir-D4 ...... 175 Aqueous ethanol ...... 43, 44, 45 7-Aminonitrazepam ...... 57, 85 L-Abrine ...... 168 Aripiprazole ...... 87 Aminorex ...... 85 Acetaminophen ...... 82, 147 Aripiprazole-D8 ...... 87 Amiodaron ...... 85 Acetaminophen-D4 (Paracetamol) ....82, 147 Aristolochic Acid A ...... 168 Amiodarone HCl ...... 85 Acetaminophen-D4 (Paracetamol) ....82, 147 Aristolochic Acid B ...... 168 Amiodarone HCl-D4 ...... 85 4-Acetoxy-N,N-diisopropyltryptamine HCl 57, Aristolochic Acid C ...... 168 Amiodarone-D4...... 85 82 Aristolochic Acid Standards Kit ...... 168, 169 4-Acetoxy-MET Fumarate) ...... 57, 82 Amisulpride ...... 85 Asbestos fibres in lung tissue ...... 30 N-Acetyl-3,4-methylenedioxyamphetamine Amisulpride-D5 ...... 85 Ascomycin ...... 88 ...... 82 Amitriptyline ...... 85 Ascorbic Acid in serum ...... 33 13-Acetyl-9-Dihydrobaccatin III ...... 168 Amitriptyline HCl ...... 57, 85 Aspartate transaminase ...... 17 N-Acetylamphetamine ...... 82 Amitriptyline-D3 ...... 86 Atazanavir ...... 88, 175 7-Acetylbaccatin III ...... 168 Amobarbital ...... 86 Atazanavir-D5 ...... 88, 175 7-Acetylbaccatin III ...... 168 (±)-Amphetamine ...... 86 Atenolol ...... 88 6-Acetylcodeine ...... 82 (±)-Amphetamine ...... 86 Atenolol ...... 58, 88 Acetylcodeine base ...... 82 R(-)-Amphetamine ...... 86 Atomoxetine HCl ...... 88 6-Acetylmorphine ...... 82 S(+)Amphetamine ...... 86 Atomoxetine-D7 HCl ...... 88 6-Acetylmorphine ...... 83 Amphetamine Sulfate ...... 86 Atorvastatin calcium salt ...... 88 6-Acetylmorphine-D3 ...... 83 (±)-Amphetamine-D10 ...... 86 Atropine ...... 88 6-Acetylmorphine-D3 ...... 83 (±)-Amphetamine-D11 ...... 86 Atropine Sulfate ...... 169 6-Acetylmorphine-D6 ...... 83 (±)-Amphetamine-D11 ...... 87 Atropine Sulphate ...... 169 6-Acetylmorphine-D6 ...... 83 (±)-Amphetamine-D5 ...... 86 Atropine sulphate ...... 58, 88 N-Acetylnorlaudanosine ...... 83 (±)-Amphetamine-D5 ...... 86 Atropine ...... 58 Acetylsalicylic Acid ...... 57, 83 Amphetamine-D6 ...... 86 Atropine-D3 ...... 88 2'-Acetyltaxol ...... 168 Amphetamine-D6 ...... 86 Baccatin I1-Hydroxy ...... 169 2'-Acetyltaxol ...... 168 (±)-Amphetamine-D8 ...... 86 Baccatin III ...... 169 7-Acetyltaxol ...... 168 (±)-Amphetamine-D8 ...... 86 B-Amyrin ...... 168 Acetylthebaol ...... 83 Amprenavir ...... 87, 175 Barbituric Acid ...... 58, 88 Aciclovir ...... 57, 83 Amprenavir-D4...... 87, 175 (±)-BDB HCl ...... 88 Aconite Standards Kit ...... 168 alpha-Amylase ...... 16 Belladonna Standards Kit ...... 169 Aconitine ...... 168 beta-Amyrin Acetate ...... 168 Benzbromarone ...... 58, 88 Acyclovir ...... 83 (+)-Anabasine HCl ...... 87 Benzedrone ...... 58, 88 Adefovir-D4, ...... 175 5beta-Androst-1-en-17beta-ol-3-one ...... 198 Benzhydrol (Diphenylmethanol) ...... 58, 88 Adenosine deaminase ...... 16 5alpha-Androst-1-ene-3alpha-ol-17one .. 213 Benzocaine ...... 58, 88 L-Adrenaline ...... 57, 83 5alpha-Androst-1-ene-3beta-17beta-diol 208 Benzodiazepine, serum ...... 183 Ajmalicine HCl ...... 168 1,4-Androstadiene-3,17-dione (Boldendione) Benzodiazepine, serum ...... 183 Ajmalicine ...... 168 ...... 206 Benzodiazepine, serum ...... 182 5alpha-Androstane-3alpha,17beta-diol ... 209 Ajmaline ...... 168 Benzodiazepine, serum ...... 183 Alanine aminotransferase ...... 16 5beta-Androstane-3alpha,17beta-diol ..... 209 Benzodiazepines in serum ...... 182 5alpha-Androstane-3alpha,17beta-diol-D3 Albaconazole ...... 174 Benzodiazepines in serum ...... 183 ...... 209 Albaconazole-D3 ...... 174 Benzodiazepines in serum ...... 183 5beta-Androstane-3alpha,17beta-diol-D5209 Albuterol...... 83 Benzodiazepines in serum ...... 182 5alpha-Androstane-3beta,17beta-diol ..... 209 Multi-component alcohol calibration kit..... 43 Benzoylecgonin-D8 ...... 89 5beta-Androstane-3beta,17beta-diol ...... 209 Multi-component alcohol mix 1000 μg/mL 43 Benzoylecgonine ...... 89 5alpha-Androstane-3beta,17beta-diol-3- Multi-component alcohol mix 4000 μg/mL 43 Benzoylecgonine in urine ...... 183 glucuronide ...... 209 Multi-component alcohol mix 500 μg/mL .. 43 Benzoylecgonine ...... 89 5beta-Androstane-3beta,17beta-diol-D3 . 209 Alfafoetoprotein (AFP) ...... 30 Benzoylecgonine ...... 89 5alpha-Androstane-3beta,17beta-diol-D3209 Alfentanyl HCl ...... 83 Benzoylecgonine isopropyl ester ...... 89 Androstanolone...... 58, 87 alpha-Hydroxymidazolam (0.1 mg/ml) in Benzoylecgonine-D3 ...... 89 1-Androstendione ...... 198, 213 Methanol ...... 119 Benzoylecgonine-D3 ...... 89 Androstendione...... 206 Alphamethadol HCl ...... 84 Benzoylecgonine-D8 ...... 89 19-Androstendione-D3 ...... 206 alpha-Methyl fentanyl D3 ...... 126 Benzyl fentanyl ...... 89 Androstene-3,17-dione-2,3,4-13C3 ... 87, 198 17 Alpha-Methyl-5 Beta-androstane-3.... 203 Benzyl fentanyl-D3 ...... 89 Androstenedione ...... 58, 87 17alpha-Methyl-5beta-androstan-3alpha- Benzyl methyl ketone (P2P) ...... 89 17beta-diol-D3 ° ...... 203 Androsterone ...... 209 1-Benzyl-3-methylnaphthalene ...... 89 alpha-Methyltryptamine ...... 134 Androsterone glucuronide ° ...... 209 N-Benzyloxymethylphenylisoserine alpha-Methythio fentanyl ...... 134 Androsterone sulfate ...... 209 Ethylester ...... 169 alpha-Yohimbine HCl (Rauwolscine HCl) 168 Androsterone sulfate-D4 ° ...... 210 N-Benzyloxymethylphenylisoserine Alprazolam ...... 84 D4-Androsterone-beta-glucuronide (free Methylester ...... 169 acid) ...... 209 Alprazolam-D5 ...... 84 Benzylpiperazine ...... 89 Androsterone-D4 ...... 209 Alprazolam-D5 ...... 84 Benzylpiperazine-D7 ...... 89 Anhydroecgonine HCl ...... 87 AM-1220 ...... 84 N-Benzylpiperazine-D8 diHCl ...... 89 Anhydroecgonine methyl ester ...... 87 AM-2201 ...... 84 Berberine Chloride ...... 169 Anhydroecgonine methyl ester ...... 87 AM-694 ...... 57, 84, 113 Bilirubin...... 18 2-Anhydrotramadol ...... 58, 87 alpha-Amanitin ...... 168 2',7-Bis-Acetyltaxol ...... 168 Anisatin ...... 168 alpha-Amanitin ...... 168 Bisoprolol Fumarate ...... 58, 90 Anticonvulsant drugs ...... 14, 181 Amino acids ...... 18 Blank, serum ...... 13 Antidepressiva, serum ...... 181 2-Amino-2',5-dichlorobenzophenone ...... 57 Blank, urine ...... 13 Antidepressiva, serum ...... 181 2-Amino-5-chlorobenzophenone ...... 57, 84 Blank, blood ...... 14 Antiepilepsy drugs ...... 15, 181 2-Amino-5-nitrobenzophenone ...... 57, 85 blood control ...... 13 Antiepileptics, serum ...... 182 7-Aminoclonazepam ...... 84 Boldenone ...... 90 5-APB HCl ...... 58, 87 7-Aminoclonazepam ...... 84 17beta-Boldenone sulfate ...... 198 6-APB HCl ...... 58, 87 7-Aminoclonazepam-D4 ...... 84 17beta-Boldenone sulfate-D3 ...... 198 6-APDB...... 87 2-Amino-4,6-dinitrotoluene ...... 162 17-alpha-Boldenone (Epiboldenone) ...... 198 Apomorphine HCl ...... 58, 87 4-Amino-2,6-dinitrotoluene ...... 162 Boldenone ...... 58, 90 Aprindine Hydrochloride ...... 58, 87 17beta-Boldenone-D3 ° ...... 198 Congener alcohols in serum ...... 45 17-beta-Boldenone glucuronide potassium Congener alcohols in serum ...... 46 salt ...... 198

238 LGC Standards – Excellence through measurement Edition 2011/2012

Product index

Bovine serum albumin ...... 18 CDT ...... 51, 184 Congener alcohols in serum ...... 49 Bromazepam ...... 90 Celiprolol Hydrochloride ...... 59, 93 Congener alcohols in serum ...... 49 Bromazepam ...... 58, 90 7-Epi-Cephalomannine ...... 169 Congener alcohols in serum ...... 49 4-Bromo-2,5 dimethoxyphenethylamine HCl Cephalomannine ...... 169 DL-Coniine HCl ...... 169 ...... 90 Cetirizine N-Oxide ...... 59, 93 DL-Coniine ...... 169 DOB ...... 90, 107 Chelerythrine Chloride ...... 169 Convallatoxin ...... 169 4-Bromo-2,5-dimethoxyphenethylamine HCl (+)-Chelidonine HCl ...... 169 Coptisine Chloride ...... 169 ...... 90 (+)-Chelidonine ...... 169 Cortisol ...... 23 (R)-(-)-Bromodragonfly HCl ...... 90 (+)-Chelidonine ...... 169 Cortisol in serum ...... 24 Bromosaffrole ...... 90 Chlopheniramine ...... 94 Cortisol in serum ...... 24 Brompheniramine maleate ...... 59, 90 Chlordiazepoxide ...... 93 Cortisol reference serum panel ...... 24 BSTFA ...... 90 Clhordiazepoxide-D5 ...... 93 Cortisol ...... 199 Buclizine dihydrochloride ...... 90 Chlormezanone ...... 59, 94 Cortisone ...... 60, 98 Bufotenine ...... 90 6-Chloro-4-(2-chlorophenyl)-2(1H)- Corynanthine (Rauhimbine) ...... 169 Bulleyaconitine A ...... 169 quinazolinone ...... 59, 94 Corynanthine HCl ...... 169 Buphedrone ...... 59, 92 6-Chloro-4-(2-chlorophenyl)-2- (-)-Cotinine ...... 98 Buphedrone ...... 59, 90 quinazolinecarboxylic Acid ...... 59, 94 Cotinine in human urine ...... 18, 28, 185 Bupranolol HCl...... 212 4-Chloro-4-androsten-3alpha-ol-17-one b Cotinine ...... 60, 98 Buprenorphine ...... 91 ...... 199 (±)-Cotinine-D3 (0.1 mg/ml) ...... 98 Buprenorphine cal ...... 184 (2-Chlorophenyl)diphenylmethanol ..... 60, 94 dl-Cotinine-D3 ...... 98 Buprenorphine cal ...... 184 4-[(4-Chlorophenyl)phenylmethyl]-1- Coumarin ...... 98 Buprenorphine cal ...... 184 piperazineethanol DiHCl ...... 59, 94 CP 47,497 ...... 99 Buprenorphine cal ...... 184 1-[(4-Chlorophenyl)phenylmethyl]piperazine (-) CP47,497 ...... 99 Buprenorphine cal ...... 184 ...... 59, 94 (+) CP47,497 ...... 99 Buprenorphine cal ...... 184 Chlorophenyl)piperazine (mCPP) HCl ...... 94 (+/-)CP,47,497 ...... 99 Buprenorphine, free base ...... 90 ortho-Chlorophenylpiperazine (oCPP HCl) CP47,497 ...... 99 Buprenorphine ...... 91 ...... 59, 94, 146 CP47,497 ...... 99 Buprenorphine-3beta-D-glucuronide ...... 91 m-Chlorophenylpiperazine hydrochloride .. 94 CP55,940 ...... 99 Buprenorphine-D4 ...... 91 Chloroquine diphosphate salt ...... 94 C-reactive protein in serum...... 32 Buprenorphine-D6 ...... 91 Chlorphenamine Maleate ...... 60, 94 Creatine kinase ...... 17 Buprenorphines in serum ...... 184 Chlorpromazine HCl ...... 94 Creatine kinase ...... 17 Buprenorphines in serum ...... 184 Chlorpromazine Hydrochloride ...... 60, 94 Creatinine and electrolytes in serum ... 19, 20 Buprenorphines in urine ...... 184 Chlorpromazine Sulphoxide ...... 60, 95 Creatinine in frozen serum ...... 20 Buprenorphines in urine ...... 184 Chlorpromazine-D3 ...... 94 Creatinine in Serum ...... 19 Bupropion HCl ...... 91 Chlorzoxazone ...... 95 Creatinine,serum ...... 20 Bupropion HCl ...... 59, 91 Cholesterol in serum ...... 19 Creatinine, serum (low) ...... 20 Butabarbital ...... 91 Cholesterol in serum ...... 19 Creatinine,serum ...... 20 Butalbital ...... 91 Cholesterol ...... 18 Creatinine interfering substances ...... 20 Butalbital-D5 ...... 91 Cimetidine ...... 95 Creatinine ...... 18 Butalbital-D5 ...... 91 trans-Cinnamoylcocaine ...... 95 Creatinine-D3 ...... 99 1,4-Butanediol...... 92 Citalopram HBr ...... 60, 95 Crypto-Tanshinone ...... 172 1,2,4-Butanetriol-1,4-dinitrate...... 162 Citalopram ...... 95 bis-(4-cyanophenyl)methanol (Letrazole 1,2,4-Butanetriol trinitrate ...... 162 Citalopram-D6 ...... 95 metabolite) ...... 198, 201, 208 Butoconazole nitrate ...... 174 Clenbuterol-D9 HCl ...... 201 Cyclazadone...... 207 Butorphanol tartrate ...... 92 Clenbuterol-d9 ...... 200 Cyclobenzaprine HCl ...... 99 Butylone HCl ...... 92 Clobazam ...... 95 Cyclobenzaprine-D3 ...... 99 Butylone Hydrochloride ...... 59, 92 Clobenzorex HCl ...... 95 Cyclopamine...... 169 Butylone ...... 92 Clobutinol ...... 59, 95 Cyclosporin A ( ...... 99 Butylone-D3 ...... 92 Clomipramine ...... 95 Cyclosporin A ...... 99 gamma-Butyrolactone ...... 92, 114 Clomipramine HCl ...... 60, 95 Cyclosporin D ...... 99 gamma-Butyrolactone-D6 ...... 92, 114 Clomipramine-D3 ...... 95 Cystatin C in serum ...... 32 BZP (Benzyl piperazine dihydrochloride) ..89 Clonazepam ...... 96 Cytisine ...... 170 Caffeine (1.0 mg/ml) in Methanol ...... 92 Clonazepam-D4 ...... 96 Cytisine (Laburnin) ...... 169 Caffeine ...... 59, 92 Clonidine ...... 96 Danshen tanshinone standards kit ...... 170 Calcifediol (25-Hydroyvitamin D3) ...... 33 Clonidine Hydrochloride ...... 60, 96 Darunavir ...... 99, 175 Calcifediol-D6 ...... 34 Clopidogrel carboxylic acid HCl ...... 96 Darunavir-D9 ...... 99, 175 Calcitriol 1,25-Dihydroxyvitamin D3 ...... 34 Cloxacillin Sodium Monohydrate ...... 60, 96 10-Deacetyl-7-Xylotaxol ...... 170 Calcitriol ...... 34 Clozapine ...... 96 10-Deacetylbaccatin V ...... 170 Calcitriol-d6 ...... 34 Clozapine ...... 60, 96 10-Deacetylbaccatin-III ...... 170 Ca, Mg, Li in serum ...... 15 Clozapine-D4 ...... 96 13-Deacetyltaxchinin I ...... 170 Calcium ...... 15 Clozapine-d8 ...... 96 10-Deacetyltaxol ...... 170 Calusterone ...... 199 Cocaethylene...... 96 10-Deacetyltaxol B ...... 170 Cannabidiol ...... 92 Cocaethylene-D3 ...... 96 10-Deacetyltaxol C ...... 170 Cannabidiol ...... 92 Cocaethylene-D8 ...... 96 Dehydroepiandrosterone (DHEA) ...... 206 Cannabidiol ...... 92, 158 Cocaine ...... 97 Dehydroepiandrosterone ...... 206 Cannabidiol-D3 ...... 92 Cocaine base...... 97 Dehydroepiandrosterone ...... 206 Cannabinol ...... 92 Cocaine HCl ...... 97 Dehydroepiandrosterone-D5) ...... 206 Carbamazepine 10,11-Epoxide ...... 59, 93 Cocaine-D3 ...... 97 Dehydroepiandrosterone-D5 ...... 99, 206 Carbamazepine ...... 93 Cocaine-D3 ...... 97 Dehydronorketamine HCl ...... 99 Carbamazepine ...... 59, 93 Codeine ...... 97 Delavirdine mesylate ...... 99, 175 Carbamazepine-D10 ...... 93 Codeine ...... 97 Delavirdine ...... 99, 175 Carboxy finasteride ...... 200 Codeine base ...... 97 Demoxepam ...... 99 (-)-11-nor-9-carboxy-delta 9-THC ...... 140 Codeine base-D3 ...... 97 Demoxepam-D5 ...... 100 (±)-11-nor-9-carboxy-delta 9-THC ...... 139 Codeine glucuronide ...... 98 11-Deoxycortisol ...... 60, 100 (±)-11-nor-9-carboxy-delta 9-THC-D3 .... 139, Codeine glucuronide-D3* ...... 98 11-Deoxycortisol ...... 199 140 Codeine phosphate hemihydrate ...... 60, 98 21-Deoxycortisol ...... 200 (±)-11-nor-9-carboxy-delta 9-THC-D9 ..... 140 Codeine-6-beta-D-glucuronide ...... 98 21-Deoxycortisol-D8 ...... 100 Carisoprodol ...... 93 Codeine-D3 ...... 97 Desacetyldiltiazem ...... 61, 100 Carisoprodol ...... 93 Codeine-D3 ...... 97 Desalkylflurazepam ...... 61, 100 Carphedrone ...... 207 Codeine-D3 ...... 98 Desalkylflurazepam ...... 100 Catecholamine Metabolites Mix ...... 93, 199 Codeine-D6 ...... 98 Desalkylflurazepam-D4 ...... 100 Catecholamine Mix 1 (Epinephrines) ...... 199 Codeine-D6 ...... 98 6-Desamino 6-chloro etravirine ...... 175 Catecholamine Mix 2 (Metanephrines) .... 199 Colchicine ...... 60, 98 2-Desbutyl-2-isopentyl-5-methyl itraconazole 2S-Cathinone HCl ...... 93 Congener alcohols in serum ...... 49 ...... 174 R(+)-Cathinone HCl ...... 93 Congener alcohols in serum ...... 49 N-Desethylamiodarone HCl ...... 100 (±)-Cathinone HCl ...... 93 Congener alcohols in serum ...... 49 N-Desethylamiodarone-D4 HCl ...... 100 Cathinone-D3 HCl ...... 93 Congener alcohols in serum ...... 49 N-Desethylamodiaquine-D5 diHCl ...... 100

Edition 2011/2012 LGC Standards – Excellence through measurement 239

Product index

Desethylchloroquine ...... 100 Dihydromethysticin ...... 170 Drugs of abuse in hair ...... 191 Desethylhydroxychloroquine DiHCl ...61, 100 Dihydromorphine ...... 105 Drugs of abuse in blood ...... 190 Deshydroxyethylopipramol DiHCl ...... 61, 100 5alpha-Dihydrotestosterone ° ...... 210 Drugs of abuse in serum ...... 191 Desipramine Hydrochloride ...... 61, 100 5alpha-Dihydrotestosterone glucuronide . 210 Drugs of abuse, blood ...... 194 Desipramine ...... 101 5alpha-Dihydrotestosterone glucuronide-D3 Drugs of abuse, hair ...... 190 Desipramine-D3 HCl ...... 101 ...... 210 Drugs of abuse, serum ...... 192 Desmethoxyyangonin ...... 170 5alpha-Dihydrotestosterone sulfate ...... 210 Drugs of abuse,serum ...... 192 O-Desmethyl Quinine ...... 102 5alpha-Dihydrotestosterone sulfate-D3 ... 210 Drugs of substitution, urine ...... 187 Desmethylbrompheniramine Maleate 61, 101 5a-Dihydrotestosterone...... 210 Drugs of substitution, urine ...... 187 Desmethylchlorphenamine Maleate ..61, 101 5alpha-Dihydrotestosterone-D3 ...... 210 Drugs of substitution ...... 187 N-Desmethyl-cis-tramadol HCl ...... 103 1alpha, 25-Dihydroxyvitamin D2 ...... 33, 105 Drugs of substitution ...... 187 O-Desmethyl-cis-tramadol HCl ...... 103 1alpha, 25-Dihydroxyvitamin D333, 105, 115 Duloxetine HCl...... 108 O-Desmethyl-cis-tramadol-D6 HCl ...... 103 Diltiazem HCl ...... 106 Duloxetine Hydrochloride ...... 64, 108 N-Desmethylcitalopram HCl ...... 101 Diltiazem HCl ...... 63, 106 Duloxetine-D3 HCl ...... 108 Desmethylcitalopram Hydrochloride ..61, 101 Dimenhydrinate...... 63, 106 Ecgonine ethyl ester ...... 108 N-Desmethylclobazam ...... 101 Dimethocaine Hydrochloride ...... 63, 106 Ecgonine HCl ...... 108 Desmethylclomipramine HCl ...... 61, 101 1,2-Dimethoxy-4-(2-propenyl)-benzene .. 106 Ecgonine HCl ...... 108 Desmethylclomipramine ...... 101 2,5-Dimethoxy-4-iodophenylethylamine HCl Ecgonine methyl ester ...... 108 Desmethylclozapine (Norclozapine) ..61, 101 ...... 106 Ecgonine methyl ester ...... 108 N-Desmethylclozapine ...... 101 (±)2,5-Dimethoxy-4-methylamphetamine Ecgonine methyl ester-D3 ...... 108 N-Desmethyldextromethorphan ...... 61, 101 HCl ...... 106 Ecgonine-D3 HCl ...... 108 O-Desmethyldextromethorphan ...... 61, 101 2,5-Dimethoxy-4-propylthio- Echimidine ...... 170 N-Desmethyldiltiazem HCl ...... 62, 102 phenylethylamine ...... 106 EDDP perchlorate ...... 109 Desmethyldoxepin (cis/trans) ...... 102 2,5-Dimethoxyamphetamine HCl ...... 106 EDDP perchlorate ...... 109 Desmethylflunitrazepam...... 62, 102 3,4-Dimethoxyamphetamine HCl ...... 106 EDDP ...... 108 N-Desmethylflunitrazepam-D4 ...... 102 17,17-Dimethyl-18-norandrosta-1,13-diene- EDDP-D3 perchlorate ...... 109 N-Desmethyllevomepromazine ...... 62, 102 3alpha-ol ...... 202 EDDP-D3 ...... 109 Desmethylolanzapine diHCl ...... 102 17,17-Dimethyl-18-norandrosta-1,4,13-trien- EDDP-D3 perchlorate ...... 109 N-Desmethylolanzapine-D8 ...... 102 3-one ...... 202 Efavirenz ...... 109, 175 (±)-N-Desmethylselegiline ...... 102 N,N-Dimethyl-3,4-methylenedioxy- rac-Efavirenz-D4 ...... 109, 175 Desmethylselegiline-D11 ...... 102 amphetamine HCl ...... 106 Electrolytes in serum ...... 16 Desmethylsibutramine Hydrochloride 62, 102 7beta,17alpha-Dimethyl-5beta-androstane- EMDP HCl ...... 109 3alpha,17beta-diol ...... 199 Desmethylsildenafil ...... 62, 102 Emtricitabine ...... 109, 175 7alpha,17alpha-Dimethyl-5beta-androstane- N-Desmethyltapentadol ...... 103 Emtricitabine-13C,15N2 ...... 109, 175 3alpha,17beta-diol ...... 198 O-Desmethyltramadol HCl ...... 62, 103 Enfuvirtide acetate ...... 175 (-)-N,N-Dimethylamphetamine HCl ...... 106 Desmethyltrimipramine HCl ...... 62, 103 ent Efavirenz ...... 175 Dimethylamylamine Hydrochloride .... 63, 106 Desmethyltrimipramine ...... 103 Entecavir-15N3 ...... 175 Dimethylcathinone Hydrochloride ..... 63, 106 N-Desmethylvenlafaxine Hydrochloride .. 62, EPA Method 8330 ...... 162, 163 3,4-Dimethylmethcathinone HCl ...... 63, 106 103 1S,2R(+)-Ephedrine ...... 109 N,N-Dimethyltryptamine ...... 106 O-Desmethylvenlafaxine ...... 62, 103 Ephedrine base ...... 109 1,3-Dinitrobenzene ...... 162 Desoxypipradrol Hydrochloride (2-DPMP Ephedrine HCl ...... 109 2,2'-Dinitrodiphenylamine ...... 162 HCl) ...... 62, 103 Ephedrine Hydrochloride ...... 64, 109 2,4-Dinitrodiphenylamine ...... 162 Desthiazolylmethyl ritonavir ...... 175 Ephedrine Sulphate ...... 64, 110 4,4'-Dinitrodiphenylamine ...... 162 Desthiazolylmethyloxycarbonyl ritonavir . 175 Ephedrine ...... 109 Dinitro ethylene glycol ...... 162 Dextorphan tartrate ...... 104 1S,2R (+)-Ephedrine-D3 HCl ...... 110 Dinitroethylene glycol ...... 162 Dextromethorphan ...... 103 1S,2R (+)-Ephedrine-D3 HCl ...... 110 1,2-Dinitroglycerin ...... 162 Dextromethorphan HBr ...... 62, 103 7-Epi Cephalomannine ...... 169 1,3-Dinitroglycerin ...... 162 Dextromethorphan-D3 ...... 104 7-Epi-10-Deacetyltaxol ...... 170 3,5-Dinitro-2-methylaniline ...... 162 Dextromoramide tartrate ...... 212 7-Epi-10-Oxo-10-Deacetyltaxol ...... 170 3,5-Dinitro-4-methylaniline ...... 162 Dextrorphan-D3 ...... 104 Epimetendiol ...... 202 2,4'-Dinitrophenylamine ...... 162 7-Keto DHEA ...... 213 17-Epimethandienone ...... 202 2,4-Dinitrotoluene ...... 162 Diacetolol Hydrochloride ...... 63, 104 R(-)-Epinephrine ...... 110 2,6-Dinitrotoluene ...... 162 Diacetylnorcodeine ...... 104 17-Epioxandrolone ...... 206 3,4-Dinitrotoluene ...... 162 Diazepam ...... 63, 104 7-Epitaxol C ...... 170 Diphenhydramine HCl ...... 107 Diazepam ...... 104 2'- Epitaxol ...... 170 Diphenhydramine HCl ...... 63, 106 Diazepam-D5 ...... 104, 107 2'-Epitaxol ...... 170 Diphenhydramine N-Oxide ...... 63, 107 Diclofenac sodium ...... 104 7-Epitaxol Solution ...... 170 Diphenhydramine-D3 ...... 107 Diclofenac Sodium ...... 63, 104 7-Epitaxol ...... 170 Diphenylamine ...... 162 Diclofensine Hydrochloride ...... 63, 104 Epitestosterone...... 210 Diphenylpyraline HCl ...... 64, 107 2í,3í-Dideoxyinosine ...... 175 Epitestosterone glucuronide ...... 210 Dipipanone HCl...... 212 2í,3í-Dideoxyinosine-15N4 ...... 175 Epitestosterone glucuronide-D3 ...... 210 Disopyramide ...... 107 Didesethylchloroquine ...... 104 Epitestosterone sulfate ° ...... 210 Oxidative DNA damage mass ...... 177 Didesmethylsibutramine Hydrochloride ... 63, Epitestosterone sulfate-D3 ° ...... 210 Plasmid DNA ...... 178 104 Epitestosterone...... 64, 110 Plasmid DNA ...... 177 N,O-Didesmethyltramadol HCl ...... 63, 105 Epitestosterone-D3 ...... 210 DNA profiling standard ...... 176 Dienoestrol, urine, blank ...... 32 Epi-Triptolide ...... 173 PCR based DNA profiling ...... 177 Dienoestrol, urine, positive ...... 32 Erhylglucuronide, urin ...... 22, 51 Domperidone ...... 64, 107 13beta,17alpha-Diethyl-5alpha-gonane- Estazolam ...... 110 Dopamine HCl ...... 107 3alpha, 17beta-diol ...... 205 Estazolam-D5 ...... 110 Dopamine-D4 HCl ...... 107 13beta,17alpha-Diethyl-5beta-gonane- Estradiol Hemihydrate ...... 64, 110 Dosulepin HCl (Dothiepin) ...... 64, 107 3alpha, 17beta-diol ...... 205 Estradiol-17-beta, serum ...... 24 Doxepin Hydrochloride ...... 64, 107 Diethylpropion HCl (Amfepramon HCl, Estradiol-17-beta,serum ...... 24 Doxepin-D3 HCl (cis/trans) ...... 107 Diethylcathinone HCl) ...... 105 5beta-Estran-3-alpha-ol-17-one ...... 204 Doxylamine Hydrogen Succinate ...... 64, 107 Diethylpropion HCl (Amfepramon HCl)l . 105 5a-Estran-3a-ol-17-one...... 204 Doxylamine-D5 ...... 107 Diethylpropion-D10 HCl ...... 105 5(10)-Estrene-3beta,17alfa-diol ...... 32, 205 Dronedarone Hydrochloride ...... 64, 108 Diethylstilboestro, urine, (positive) ...... 32 Estriol ...... 64, 110, 200 Drugs / medicaments cut-off - 25 % urine Diethylstilboestrol, urine ...... 32 Estrone ...... 64, 110, 200 ...... 193 N,N-Diethyltryptamine ...... 105 Ethanol calibration kit ...... 43 Digitoxin ...... 105 Drugs / medicaments cut-off + 25 % urine ...... 193 Ethanol in serum ...... 46, 47, 48 Digoxin ...... 105 Ethanol in blood ...... 50 Digoxin in serum ...... 15 Drugs and alcohol, urine FDT-25% ...... 194 Drugs and alcohol, urine FDT+25% ...... 194 Ethanol in blood ...... 50 Digoxin ...... 14, 63, 105 Ethanol in blood ...... 50 2 170 Drugs / medicaments, cut-off + 25 % urine ...... 192 Ethanol in blood ...... 50 Dihydrocodeine HCl ...... 105 Ethanol in serum ...... 48 Dihydrocodeine hydrogen tartrate ...... 105 Multi-drugs of abuseurine ...... 194 Drugs of abuse in hair - DHF 2/10 ...... 190 Ethanol in blood ...... 50 Dihydrocodeine-D6 HCl ...... 105 Ethanol, aqueous ...... 45 Dihydrokavain ...... 170 Drugs of abuse in hair ...... 191

240 LGC Standards – Excellence through measurement Edition 2011/2012

Product index

Ethanol, aqueous ...... 45 4-Fluoroamphetamine HCl ...... 65, 112 Hydrocodone-D6 ...... 116 Ethanol/water - 40% Ethanol ...... 41 p-Fluorococaine ...... 112 Hydrocodone-D6 ...... 116 Ethanol/water - 5% Ethanol ...... 41 3-Fluoromethcathinone HCl ...... 113 Hydrocortisone ...... 65, 117 Ethanol/water - 70% Ethanol ...... 41 2-Fluoromethcathinone HCl ...... 65, 113 Hydromorphone ...... 116 Ethanol ...... 42, 43 3-Fluoromethcathinone Hydrochloride ..... 65, Hydromorphone HCl ...... 116 Ethanol in water ...... 41 113 Hydromorphone-3beta-D-glucuronide .... 117 Ethanol-water solution ...... 41, 42 4-Fluorotropacocaine ...... 65, 113 Hydromorphone-D3 ...... 116 Ethanol-water solutions ...... 42 Fluoxetine HCl ...... 113 Hydromorphone-D3 ...... 117 Ethosuximide ...... 64, 111 Fluoxetine HCl ...... 65, 113 Hydromorphone-D4 ...... 117 Ethyl beta-D-glucuronide ...... 50, 111 Fluoxetine-D6 oxalate ...... 113 Hydromorphone-D6 ...... 117 Ethyl beta-D-glucuronide-D5 ...... 50, 111 Fluoxymesterone ...... 113, 200 16beta-Hydroxy DHEA ...... 213 Ethyl myristate ...... 50 Fluoxymesterone ...... 65, 113 4beta-Hydroxy DHEA ...... 213 Ethyl myristate-ethyl-D5 ...... 50 trans-(E)-Flupentixol bromide ...... 113 7alpha-Hydroxy DHEA ...... 213 Ethyl oleate ...... 50 trans-(E)-Flupentixol bromide ...... 113 7beta-Hydroxy DHEA ...... 213 Ethyl oleate-ethyl-D5 ...... 50 cis-(Z)-Flupentixol bromide ...... 113 rac 7-Hydroxy efavirenz ...... 175 Ethyl palmitate ...... 50 cis-(Z)-Flupentixol bromide ...... 113 rac 8-Hydroxy efavirenz ...... 118, 175 Ethyl palmitate-ethyl-D5 ...... 50 Fluphenazine ...... 113 rac 8-Hydroxy efavirenz-D4 ...... 118 Ethyl stearate ...... 50 Fluphenazine Dihydrochloride ...... 65, 113 Hydroxy fentanyl ...... 119 Ethyl stearate-ethyl-D5 ...... 50 Flurazepam ...... 113 Hydroxy fentanyl-D3 ...... 119 Ethyl sulfate sodium salt ...... 111 N-Formyl di(phenylisopropylamine) ...... 114 Hydroxy itraconazole ...... 174 Ethyl sulfate ...... 50 N-Formyl-1-phenylethylamine ...... 114 Hydroxy Itraconazole-D5 ...... 174 Ethyl sulfate-D5 ...... 50 (±)-N-Formyl-3,4- Hydroxy Itraconazole-D8 ...... 174 17alpha-Ethyl-5alpha-estrane- methylenedioxyamphetamine ...... 114 2-Hydroxy nevirapine...... 119 3alpha,17beta-diol ...... 205 N-Formylamphetamine ...... 114 7-Hydroxy quetiapine...... 119 17alpha-Ethyl-5beta-estrane-3alpha,17beta- N-Formyl-N-methyl-3,4- 10-Hydroxy-10,11-dihydrocarbamazepine66, diol ...... 205 methylenedioxyamphetamine ...... 114 118 17a-Ethyl-5ß-estrane-3a-17b-diol ...... 205 N-Formyl-N-methylamphetamine ...... 114 4-Hydroxy-3-methoxy-DL-mandelic acid ... 18 (±)-N-Ethylamphetamine HCl ...... 110 N-Formylnorcocaine ...... 114 (±)-4-Hydroxy-3-methoxymandelic Acid-D3 (±)-N-Ethylamphetamine ...... 110 Fosamprenavir calcium salt ...... 114 ...... 199 Ethyl-beta-D-6-glucuronide ...... 18, 50 Fragile X Human DNA ...... 177 4-Hydroxy-3-methoxyphenyl-D3-acetic-D2 Ethyl-beta-D-6-glucuronide-D5 ...... 18, 50 Trace metals (Cu, Se, Zn) in serum ...... 28 Acid (HVA-D5) ...... 199 Ethyl-beta-D-glucuronide ...... 111 Furosemide ...... 114 3alpha-Hydroxy-4-estren-17-one ...... 214 Ethyl-beta-D-glucuronide-D5...... 111 Furosemide ...... 65, 114 3beta-Hydroxy-4-estren-17-one ...... 214 Ethyl centralite ...... 162 Gabapentin ...... 114 3-Hydroxy-4-methoxytamoxifen ...... 200, 206 Ethyl-D5 sulfate sodium salt ...... 111 Gabapentin-D10 ...... 114 alpha-Hydroxyalprazolam ...... 117 Ethylglucuronide in serum ...... 51 Gammabutyrolactone (GBL) ...... 65, 114 alphaHydroxyalprazolam ...... 117 Ethylglucuronide in serum ...... 20, 51 Gentamicin Sulfate ...... 114 alpha-Hydroxyalprazolam-D5 ...... 117 Ethylglucuronide in serum ...... 22, 51, 185 Gestrinone ...... 208 alpha-Hydroxyalprazolam-D5 ...... 117 Ethylglucuronide in serum ...... 22, 51, 185 GHB ...... 114 10-Hydroxyamitriptyline ...... 66, 117 Ethylglucuronide in serum ...... 51, 185 GHB ...... 114 4-Hydroxyamphetamine HCl (HMA) ...... 117 Ethylglucuronide, serum ...... 20, 51 GHB-D6 ...... 115 4-Hydroxyandrostendione ...... 201 beta-Ethylmethcathinone HCl ...... 64, 111 GHB-D6 ...... 115 6beta-Hydroxyandrosterone ° ...... 213 Ethylmorphine ...... 111 Glaucine HBr ...... 170 16alpha-Hydroxyandrosterone ...... 213 Ethylone HCl ...... 111 D-Glucose ...... 18 m-Hydroxybenzoylecgonin ...... 118 Ethylone Hydrochloride ...... 111 Glucose in serum ...... 20 (±)-Hydroxybupropion ...... 118 Ethylone ...... 111 Glucose in serum ...... 21 (±)-Hydroxybupropion-D6 ...... 118 Ethylone-D5 HCl ...... 111 Glutamyltransferase ...... 17 Hydroxychloroquine sulphate ...... 66, 118 Ethylone-D5 ...... 111 Glutethimide ...... 115 6-Hydroxychlorzoxazone ...... 118 17a-Ethynylestradiol ...... 111 Glycated haemoglobin ...... 32 6-Hydroxychlorzoxazone-D2,15N ...... 118 Etilephrine HCl ...... 110, 212 Griseofulvin ...... 65, 115 trans-3'-Hydroxycotinine methyl-D3 ...... 118 Etiocholanolone ° ...... 210 Haemiglobincyanide,blood ...... 31 trans-3'-Hydroxycotinine ...... 118 Etiocholanolone glucuronide ° ...... 211 Haemoglobin HbA0 in blood ...... 31 7-Hydroxycoumarin ...... 118 Etiocholanolone sulfate ° ...... 211 Haloperidol ...... 115 7-Hydroxycoumarin-13C6 ...... 118 Etiocholanolone sulfate-D5 ° ...... 211 Haloperidol-D4 ...... 115 4-Hydroxycyclofenil ...... 206 Etiocholanolone-D5 ...... 211 Harmaline HCl ...... 170 11-hydroxy-delta 9-THC ...... 120 Etravirine ...... 175 Harmaline ...... 170 Hydroxy-delta 9-THC-D3 ...... 120 Etravirine-13C3 ...... 175 Harmine HCl ...... 170, 171 4'-Hydroxydiclofenac ...... 118 Etravirine-D8 ...... 175 Harmine ...... 115, 171 4'-Hydroxydiclofenac-13C6 ...... 118 Explosives ...... 163 HbA1c in haemoglobin ...... 30 2-Hydroxyethylflurazepam ...... 118, 119 Famprofazone...... 207 Heptaminol HCl ...... 208 2-Hydroxyethylflurazepam-D4 (0.1 mg/ml) in Ccholesterol and vitamins in serum .... 19, 33 Heroin ...... 115 Methanol ...... 119 Fenbutrazate HCl ...... 207 Heroin base ...... 115 2-Hydroxyethylflurazepam-D4 (1.0 mg/ml) in Fencamine ...... 207 Heroin-D9 ...... 115 Methanol ...... 119 Fenetylline HCl ...... 111, 208 Heroin-D9 ...... 115 6beta-Hydroxyetiocholanolone ...... 214 Fenfluramine ...... 112 Heteroplasmic mitochondrial DNA ...... 177 6beta-Hydroxyfluoxymesterone ...... 200 Fenfluramine Hydrochloride ...... 64, 111 Hexobarbital ...... 115 16beta-Hydroxyfurazabol ° ...... 200 Fenfluramine-D10 ...... 112 Hexoestrol, urine, blank ...... 32 10-Hydroxyimipramine BH3-Aduct.... 66, 119 Fenproporex HCl ...... 208 Hexoestrol, urine, positive ...... 32 5-Hydroxyindole-4,6,7-D3-3-acetic-D2 Acid Fentanyl ...... 112 11-hydroxy-delta 9-THC ...... 120 (5-HIAA-D5) ...... 119 Fentanyl ...... 112 7-hydroxymitragynine ...... 171 2-Oxo-3-hydroxy-LSD ...... 126, 145 Fentanyl base ...... 112 HMX ...... 162 4-Hydroxymephenytoin ...... 119 Fentanyl citrate ...... 112 Homatropine ...... 171 6beta-Hydroxymethandienone ° ...... 202 Fentanyl ...... 65, 112 Homocysteine and folate in serum ...... 21 2-Hydroxymethyl-17alpha- Fentanyl-D5 ...... 112 Hordenine HCl ...... 65, 116 methylandrostadiene-diol-3-one ...... 200 Fialuridine-15N2,13C ...... 175 HU-210 ...... 116 2alpha-hydroxymethylethisterone ...... 199 Flephedrone ...... 65, 113 HU-331 ...... 116 alpha-Hydroxymidazolam (1.0 mg/mL) in Fluconazole ...... 174 Human apolipoprotein A I ...... 30 Methanol ...... 119 Fluconazole-D4 ...... 174 Human cardiac troponin complex ...... 31 alpha-Hydroxymidazolam-D4 (0.1 mg/ml) in Acetonitrile ...... 119 Flunitrazepam ...... 112 Human DNA ...... 176 Flunitrazepam ...... 65, 112 Human serum (Ca, Li, Mg, K, Na) ...... 16 4-Hydroxynandrolone (Oxabolone) ° ...... 201 4-Hydroxynordiazepam ...... 119 Flunitrazepam-D7 ...... 112 Human Y-chromosome DANN ...... 177 p-Fluoro fentanyl ...... 112 Hydromorphone-D6 ...... 117 6beta-Hydroxy-oral turinabol ...... 205 17alpha-Hydroxyprogesterone ...... 120 p-Fluoro fentanyl-D3 ...... 112 Hydrochlorothiazide ...... 116 9alpha-Fluoro-17,17-dimethyl-18-nor- Hydrochlorothiazide ...... 65, 116 7-Hydroxyquetiapine...... 119 androstan-4,13-diene-11 ...... 200 Hydrocodone ...... 116 7-Hydroxyquetiapine-D3 ...... 119 9alpha-Fluoro-17alpha-methyl-4-androsten- Hydrocodone-D3 ...... 116 9-Hydroxyrisperidone ...... 119 3alpha, 6beta,11be ...... 200 Hydrocodone-D3 ...... 116 9-Hydroxyrisperidone ...... 66, 119

Edition 2011/2012 LGC Standards – Excellence through measurement 241

Product index

16beta-Hydroxystanozolol ...... 207 JWH-251 ...... 123 (± )MDA ...... 127 4alpha-Hydroxystanozolol ° ...... 207 JWH-302 ...... 123 (±)-MDA-D5 ...... 127 3'-Hydroxystanozolol ...... 206 Kava Kava Standards Kit ...... 171 (±)-MDA-D5 ...... 127 4beta-Hydroxystanozolol ° ...... 207 DL-Kavain ...... 171 MDAT (6,7-Methylenedioxy-2-aminotetralin) 3'-Hydroxystanozolol glucuronide...... 207 Ketamine HCl ...... 123 ...... 127 16ß-Hydroxystanozolol ...... 207 (±) Ketamine HCl ...... 123 MDAT HCl ( ...... 67, 127 3'-Hydroxystanozolol-D3 ...... 207 Ketamine HCl ...... 66, 123 MDEA HCl ...... 127 3'-P-Hydroxytaxol ...... 171 Ketamine-D4 HCl ...... 123 (±)-MDEA ...... 127 6beta-Hydroxytestosterone ...... 201 Keto itraconazole ...... 174 (±)-MDEA-D5 ...... 127 4-Hydroxytestosterone ...... 201 Ketoconazole ...... 174 (±)-MDEA-D6 ...... 127 6beta-Hydroxytestosterone-D3 ...... 201 Ketoconazole-D8 ...... 174 MDMA HCl ...... 127 4-Hydroxytolbutamide ...... 120 Ketotifen Hydrogen Fumarate ...... 67, 123 (±)-MDMA ...... 127 4-Hydroxytolbutamide-D9 ...... 120 Ketotifen ...... 67, 123 (±)-MDMA-D5 ...... 127 alpha-Hydroxytriazolam ...... 120 Kratom Balinese (Mitragyna speciosa) leaf (±)-MDMA-D5 ...... 127 alpha-Hydroxytriazolam-D4 ...... 120 BRM ...... 171 Mefenorex HCl...... 208 25-Hydroxyvitamin D2 ...... 33, 120 Kratom Dominican (Mitragyna speciosa) leaf Mefentanyl ...... 126 25-Hydroxyvitamin D2 ...... 33, 120 BRM ...... 171 Melamine ...... 67, 127 25-Hydroxyvitamin D2 and D3 ...... 33 LAAM-HCl ((levo)-a-Acetylmethadol HCl) Melatonin ...... 127 25-Hydroxyvitamin D2 ...... 33 ...... 123 Melatonin-D7 ...... 127 D6-25-Hydroxyvitamin D3 ...... 33, 120 Lactate dehydrogenase (LDH) in bovine 5-MeO-DALT ...... 68, 128 25-Hydroxyvitamin D3 ...... 33, 121 serum albumine ...... 17 Meperidine ...... 128 25-HydroxyvVitamin D3 ...... 33, 121 Lactate dehydrogenase isoenzyme 1...... 17 Meperidine ...... 128 Hydroxyzine Hydrochloride ...... 66, 121 Lamivudine ...... 123, 175 Meperidine in serum ...... 185 Hyoscyamine Sulfate ...... 171 Lamivudine-15N2,13C ...... 123, 175 Meperidine in serum ...... 185 L-Hyoscyamine ...... 171 Lamotrigine ...... 67, 124 Meperidine-D4 ...... 128 Hypaconitine ...... 171 LAMPA (Lysergic acid N,N- Meperidine-D4 ...... 128 Ibogaine ...... 121 methylpropylamide) ...... 124 Mephedrone HCl ...... 128 Ibotenic Acid ...... 171 LAMPA (Lysergic acid N,N- Mephedrone-D3 HCl ...... 128, 133 Ibuprofen...... 121 methylpropylamide) ...... 124 Meprobamate ...... 128 Ibuprofen...... 66, 121 Lanoconazole ...... 174 Meprobamate-D4 ...... 128 Iminodibenzyl (10,11-Dihydro-5H- Lanoconazole-D3 ...... 174 Mercury in urine ...... 23, 29 dibenzo[b,f]azepine) ...... 66, 121 Lappaconitine ...... 171 Meropenem sodium salt ...... 126 Imipenem monohydrate ...... 121 Latex spheres ...... 37 Mescaline HCl ...... 128 Imipramine HCl ...... 121 Latex spheres ...... 37 Mescaline hydrogen sulfate ...... 128 Imipramine Hydrochloride ...... 66, 121 Latex spheres ...... 37 Mescaline-D9 HCl ...... 128 Imipramine N-Oxide ...... 66, 121 Lead and Cadmium in blood ...... 22, 26, 27 creatinine, cholesterol, glucose, urea, uric Seronorm Immunoassay Liquid L-1 ...... 34 Lead and cadmium in blood ...... 27 acid in urine ...... 21 Seronorm Immunoassay Liquid L-3 ...... 34 Lead and cadmium in blood ...... 27 Metamizole Sodium Monohydrate .... 67, 129 Indinavir sulphate ...... 121, 175 Pb, Cd in blood (high) ...... 23, 25 (±)--Methamphetamine-D5 ...... 130 Indinavir sulphate-D6 ...... 121 Pb, Cd in blood (low) ...... 23, 25 (±)-Metanephrine-D3 HCl ...... 199 Indinavir-D6 ...... 175 Pb, Cd in blood (medium) ...... 23, 25 Metaxalone ...... 128 5-Iodo-2-aminoindane (5-IAI) Hydrochloride Lead in blood ...... 22, 26 Metaxalone-D6 ...... 129 ...... 66, 121 Lead ...... 22 Metformin Hydrochloride ...... 67, 129 Iron metal ...... 22 (-)-Levamisole HCl ...... 124 (±)-Methadone ...... 129 Isometheptene mucate ...... 208 Levetiracetam ...... 124 (±)-Methadone ...... 129 Itraconazole ...... 174 Levetiracetam-D6 ...... 124 Methadone HCl...... 129 Itraconazole-D5 ...... 174 Levocetirizine Dihydrochloride ...... 67, 124 (±)-Methadone-D3 ...... 129 Japanese Star anis (Illicium anisatum) Fruit Levomepromazine Maleate ...... 67, 124 (±)-Methadone-D3 ...... 129 VBRM ...... 171 Levomepromazine Sulphoxide ...... 67, 124 (±)-Methadone-D9 ...... 129 Jervine ...... 171 Levomethorphan ...... 124 (±)-Methadone-D9 ...... 129 JWH-398 ...... 123 Lidocaine ...... 124 (±)-Methamphetamine ...... 129 JWH 007-D9 ...... 121 Lidocaine ...... 67, 124 (±)-Methamphetamine ...... 130 JWH 015-D7 ...... 121 Lipase ...... 17 R(-)-Methamphetamine ...... 130 JWH 081-D9 ...... 122 Lipase ...... 17 S(+)-Methamphetamine ) ...... 130 JWH 122-D9 ...... 122 Seronorm Lipid ...... 21 Methamphetamine HCl ...... 67, 129 JWH 200-D5 ...... 123 Lipids in serum...... 21 (±)-Methamphetamine-D11 ...... 130 JWH 210-D9 ...... 123 Lithium carbonate ...... 15 (±)-Methamphetamine-D14 ...... 130 JWH 250-D5 ...... 123 Lopinavir metabolite ...... 124, 175 (±)-Methamphetamine-D5 ...... 130 JWH-007 ...... 121 Lopinavir metabolite ...... 124, 175 (±)-Methamphetamine-D8 ...... 130 JWH-007 ...... 121 Lopinavir ...... 124, 175 (±)-Methamphetamine-D8 ...... 130 JWH-015 ...... 66, 121 Lopinavir-D8 ...... 124, 175 (±)-Methamphetamine-D9 ...... 130 JWH-015 ...... 121 Loratadine ...... 125 Methandienone ...... 202 JWH-018 ( N-Pentyl-3-(1-naphthoyl)indole) Loratadine ...... 67, 124 Methandienone ...... 130, 202 ...... 122 Lorazepam ...... 125 Methaqualone ...... 130 JWH-018 ...... 122 Lorazepam glucuronide ...... 125 Methaqualone-D7 ...... 130 JWH-018 ...... 122 Lorazepam ...... 67, 125 S(-)-Methcathinone ...... 131 JWH-018 ...... 122 Lorazepam-D4 ...... 125 R(+)-Methcathinone HCl ...... 131 JWH-018-D11 ...... 122 Lorazepam-D4 ...... 125 Methcathinone ...... 130 JWH-019 ...... 122 Lormetazepam ...... 125 Methcathinone-D3 ...... 131 JWH-019 ...... 122 LSA (lysergic acid amide) ...... 125 Methedrone HCl ...... 131 JWH-073 ...... 122 LSD ...... 125 Methedrone Hydrochloride ...... 67, 131 JWH-073l ...... 122 iso-LSD (iso-Lysergic acid diethylamide)121, Methedrone-D3 HCl ...... 131 JWH-073 ...... 122 126 Methenolone ...... 131, 202 JWH-081 ...... 122 LSD ...... 125 Methohexital ...... 131 JWH-081 ...... 122 LSD ...... 125 Methohexital-D5 ...... 131 JWH-122 ...... 66, 122 nor-LSD/nor-iso-LSD ...... 126, 142 Methotrexate ...... 131 JWH-122 ...... 122 LSD-D3 ...... 126 Methoxetamine Hydrochloride ...... 68, 131 JWH-147 ...... 122 LSD-D3 ...... 126 2-Methoxy-5-sulphamoylbenzamide . 68, 131 JWH-200 ...... 122 Magnesium gluconate dihydrate ...... 15 5-Methoxy-alpha-methyltryptamine ...... 131 JWH-200 ...... 122 Maprotiline HCl ...... 126 5-Methoxy-diallyltryptamine ...... 131 JWH-201 ...... 123 Maprotiline Hydrochloride ...... 67, 126 5-Methoxy-diisopropyltryptamine ...... 131 JWH-203 ...... 123 Maraviroc ...... 175 4'-Methoxymethcathinone HCl (Methedrone) JWH-203 ...... 66, 123 Maraviroc-D6 ...... 175 ...... 131 JWH-210 ...... 123 MBDB ...... 126 1-(2-Methoxyphenyl)piperazine JWH-210 ...... 123 (±)-MBDB HCl ...... 126 Dihydrochloride...... 68, 131 JWH-250 ...... 123 (±)-MBDB-D5l ...... 126 Methyl codeine ...... 132 JWH-250 ...... 123 MDA ...... 127 Methyl ecgonine ...... 132

242 LGC Standards – Excellence through measurement Edition 2011/2012

Product index alpha-Methyl fentanyl ...... 126 Methysticin ...... 171 Nitine (Benzyl analog of Taxol) ...... 171 4-Methyl-1-(3-methylpyridin-2-yl)-2- Metoprolol Tartrate ...... 68, 134 Nitrazepam ...... 138 phenylpiperazine ...... 68, 133 Metroprolol tartrate ...... 134 Nitrazepam ...... 69, 138 N-Methyl-1-phenylethylamine HCl ...... 134 Mianserin HCl ...... 134 Nitrazepam-D5 ...... 139 17alpha-Methyl-1-testosterone ...... 203 Mianserin HCl ...... 69, 134 Nitrobenzene ...... 162 2-Methyl-2-butanol ...... 68, 132 Mianserin N-Oxide ...... 69, 134 Nitropenta ...... 162 N-Methyl-2-phenylethylamine HCl .... 68, 134 Mianserin-D3 ...... 134 2-Nitrotoluene ...... 162 2-Methyl-3-(3,4-methylenedioxyphenyl)- Mibolerone ...... 211 4-Nitrotoluene ...... 162 methyl glycidate ...... 133 Midazolam ...... 134 19-Norandrostendione (Estrendione) ...... 206 N-Methyl-3,4-methylenedioxybenzylamine Midazolam-D4 maleate ...... 135 Norandrostenedione ...... 70, 139 HCl ...... 133 Milnacipran HCl ...... 135 Norandrosterone ° ...... 204 1-Methyl-3-phenylpiperazine ...... 68, 134 Mirtazepine ...... 135 19-Norandrosterone glucuronide ...... 204 1-Methyl-4-(phenylmethyl)piperazine HCl 68, Mitochondrial DNA sequencing ...... 177 19-Norandrosterone glucuronide-D4 (Na+ 134 Mitochondrial DNA sequencing ...... 177 salt) ...... 204 17a-methyl-5a-androstane-3a,17 Beta .... 203 Mitragynine ...... 171 19-Norandrosterone in 1,2-dimethoxyethane 1alpha-Methyl-5alpha-androstan- Mitraphylline ...... 171 ...... 212 3alpha,17beta-diol ...... 201 Moclobemide ...... 69, 135 19-Norandrosterone in Freeze Dried Urine 1alpha-Methyl-5alpha-androstan- Modafinil acid...... 135 ...... 212 3alpha,17beta-diol gluc...... 201 Modafinil ...... 135 19-Norandrosterone sulfate ...... 204 1alpha-Methyl-5alpha-androstan-3alpha-ol- Modafinil-D10 ...... 135 19-Norandrosterone-D4 ...... 204 17-one ...... 202 Molsidomine ...... 69, 135 Noratropine HCl ...... 139 2alpha-Methyl-5alpha-androstan-3alpha-ol- 6-Monoacetylmorphine base...... 135 Norbenzoylecgonine ...... 139 17-one ...... 199 3-Monoacetylmorphine sulfamate ...... 135 Norbolethone ...... 205 2alpha-Methyl-5alpha-androstan-3alpha-ol- 1-Mononitroglycerin ...... 162 Norbuprenorphine ...... 139 17-one gluc...... 199 2-Mononitroglycerin ...... 162 Norbuprenorphine glucuronide ...... 139 1alpha-Methyl-5alpha-androstan-3alpha-ol- Morphin-6beta-D-glucuronide ...... 136 Norbuprenorphine ...... 139 17-one gluc...... 202 Morphine ...... 135 Norbuprenorphine-D3 ...... 139 17alpha-Methyl-5alpha-androstane- Norbuprenorphine-D3 ...... 139 3alpha,17beta-diol ...... 203 Morphine ...... 136 Norcocaine ...... 140 17alpha-Methyl-5beta-androstane- Morphine and codeine in urine ...... 186 Norcocaine HCl ...... 140 3alpha,17beta-diol ...... 203 Morphine ...... 136 Norcodeine ...... 140 4'-Methyl-alpha-pyrrolidinobutiophenone .68, Morphine base-D3 ...... 136 Norcodeine ...... 140 134 Morphine glucuronide in urine ...... 186 Norcodeine ...... 70, 140 1-Methylamino-1-(3,4- Morphine HCl trihydrate ...... 69, 135 methylenedioxyphenyl)propane ... 68, 132 Morphine hemisulphate pentahemihydrate Nordazepam ...... 70, 140 Methylaminorex ...... 132 ...... 69, 135 Nordiazepam ...... 141 (±)-S-Methylamphetamine HCl ...... 132 Morphine N-Oxide ...... 137 Nordiazepam-D5 ...... 141 (±)-4-Methylamphetamine hydrochloride 132, Morphine-3beta-D-glucuronide ...... 136 Nordiazepam-D5 ...... 141 208 Morphine-3ß-D-glucuronide ...... 136 Nordiphenhydramine Hydrochloride . 70, 141 (±)-Methylamphetamine HCl ...... 132 Morphine-3ß-D-glucuronide-D3 ...... 136 Norephedrine HCl (Phenylpropanolamine) N-(3-Methylbenzyl)piperazine DiHCl . 68, 132 Morphine-6-beta-D-glucuronide ...... 137 ...... 141, 208 Methyl-D3-malonic acid ...... 133 Morphine-6ß-D-glucurunide-D3 ...... 137 Norephedrine HCl ...... 150 Methyldienolone ...... 203 Morphine-D3 ...... 136 Norephedrine-D3 ...... 141 1-Methylene-5alpha-androstan-3alpha-ol- Morphine-D3 ...... 136 Norethandrolone ...... 205 17-one ...... 202 Morphine-D6 ...... 136 19-Noretiocholanolone ...... 204 1-Methylene-5alpha-androstan-3alpha-ol- Morphine-D6 ...... 136 19-Noretiocholanolone glucuronide ...... 205 17-one gluc...... 202 Morphinhemisulfat-Pentahemihydrat ...... 135 19-Noretiocholanolone sulfate ° ...... 213 5,6-Methylenedioxy-2-aminoindane (MDAI) MTBSTFA ...... 137 Noretiocholanolone-D3 ...... 205 ...... 68, 132 Multi-component alcohol mix 100 μg/mL... 43 19-Noretiocholanolone-D4 ° ...... 205 3',4'-Methylenedioxy-alpha- Muscimol ...... 171 Norfenfluramine Hydrochloride ...... 70, 141 pyrrolidinobutiophenone ...... 68, 132 Mycophenolic acid ...... 137 Norfentanyl oxalate ...... 141 (+/-)-3,4-Methylenedioxy-alpha- Mycophenolic Acid ...... 69, 137 Norfentanyl-D5 oxalate ...... 141 pyrrolidinopropiophenone HCl ...... 132 Mycophenolic acid-beta-D-glucuronide ... 137 Norfluoxetine oxalate ...... 141 3,4- Methylenedioxybenzyl methyl Mycophenolic acid-D3 ...... 137 Norfluoxetine-D6 oxalate ...... 141 ketoximine ...... 132 Myristicin ...... 171 (±)-Norketamine HCl...... 141 3,4-Methylenedioxymethcathinone HCl ... 132 Nalbuphine HCl ...... 137 (±)-Norketamine-D4HCl ...... 142 Methylenedioxymethcathinone-D3 HCl ... 132 Naloxone ...... 137 Normeperidine ...... 142 3,4-Methylenedioxy-N-benzylcathinone ...68, Naloxone Hydrochloride Dihydrate ... 69, 137 Normeperidine-D4 ...... 142 132 Naloxone-D5 ...... 137 (±)-Normetanephrine-D3 ...... 199 1-(3,4-Methylenedioxyphenyl)-2- 6ß-Naltrexol ...... 137 Normorphine...... 142 nitropropene ...... 132 Naltrexone ...... 138 Normorphine...... 142 1-(3,4-Methylenedioxyphenyl)-propan-2-ol Naltrexone Hydrochloride ...... 69, 138 Noroxycodone HCl ...... 142 ...... 132 Naltrexone-D3 ...... 138 Noroxycodone Hydrochloride ...... 70, 142 bis-(1-(3,4-Methylenedioxyphenyl)-propan-2- 17alpha-Nandrolone (Epi-nandrolone) Noroxycodone-D3 ...... 140, 142 yl)amine HCl ...... 132 sulfate ...... 203 Noroxymorphone ...... 142 3,4-Methylenedioxyphenylacetone (MDP2P) 17beta-Nandrolone decanoate ° ...... 204 Noroxymorphone ...... 143 ...... 132 17 beta-Nandrolone sulfate (Na+ salt) .... 204 Norpheniramine Maleate ...... 70, 143 133 3,4-Methylenedioxypyrovalerone HCl ..... 17beta-Nandrolone sulfate-D3 ...... 204 Norphenylephrine ...... 143 Methylenedioxypyrovalerone HCl ...... 132 17-alpha-Nandrolone (Epinandrolone) .... 203 (±)-Norpropoxyphene ...... 143 3,4-Methylenedioxypyrovalerone ...... 133 Nandrolone ...... 69, 138 (±)-Norpropoxyphene-D5 maleate ...... 143 Methylenedioxypyrovalerone-D8 HCl ...... 133 17beta-Nandrolone-13C2 ° ...... 203 (±)-Norpropoxyphene-D5 maleate ...... 143 3,4-Methylenedioxytoluene ...... 133 17beta-Nandrolone-D3 ...... 203 Norpseudoephedrine HCl (Cathine). 93, 143, Methylephedrine ...... 133 17-beta-Nandrolone glucuronide potassium 208 (-)-Methylephedrine HCl ...... 133 salt ...... 204 Norpseudoephedrine ...... 93, 143 Methylethcathinone HCl ...... 68, 133 Naphyrone HCl ...... 138 Norsertraline HCl ...... 143 Methylmalonic acid ...... 133, 211 1-Naphyrone ...... 69, 138 Nortetrazepam ...... 70, 143 (±)-4'-Methylmethcathinone HCl Naphyrone Hydrochloride ...... 69, 138 Nortilidine HCl ...... 143 (Mephedrone) ...... 133, 134 Naproxen ...... 138 Nortilidine-D3 HCl ...... 143 Methylone HCl ...... 133 Naproxen ...... 69, 138 Nortriptyline ...... 144 Methylone Hydrochloride ...... 68, 133 Nelfinavir hydroxy-tert-butylamide ...... 138 Nortriptyline Hydrochloride ...... 70, 144 Methylone-D3 HCl ...... 133 Nelfinavir mesylate ...... 138, 175 Nortriptyline-D3 HCl...... 144 Methylphenidate HCl ...... 133 Nelfinavir-D3 ...... 138, 175 Noscapine (Narcotine) base ...... 144 Methylphenidate-D9 ...... 134 N-Ethylcathinone HCl ...... 111 Noscapine (Narcotine) HCl ...... 146 N-Methylritonavir bicarbonate ...... 175 Nevirapine ...... 138, 175 O-Desmethylsulpiride ...... 62, 103 17-alpha-Methyltestosterone...... 203 Nevirapine-D5...... 138, 175 Ohmefentanyl ...... 144 3-Methylthio fentanyl ...... 134 S(-)-Nicotine ...... 138 Ohmefentanyl-D3 ...... 144 (±) Methylthioamphetamin HCl (MTA) .....131 Nicotine ...... 69, 138 Olanzapine ...... 144 4-Methylthioamphetamine HCl ...... 134 Nicotine-D4 ...... 138 Olanzapine D3 ...... 144

Edition 2011/2012 LGC Standards – Excellence through measurement 243

European Commission Joint Research Centre Institute for Reference Materials and Measurements (JRC IRMM), Belgium Bundesanstalt für Materialforschung und -prüfung (BAM) Germany LGC United Kingdom

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