Pharmacological Characterization of H05, a Novel Serotonin And
Supplemental material to this article can be found at: http://jpet.aspetjournals.org/content/suppl/2018/04/03/jpet.118.248351.DC1 1521-0103/365/3/624–635$35.00 https://doi.org/10.1124/jpet.118.248351 THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J Pharmacol Exp Ther 365:624–635, June 2018 Copyright ª 2018 by The American Society for Pharmacology and Experimental Therapeutics Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT2A Antagonist Activity for the Treatment of Depression s Xiangqing Xu, Yaqin Wei, Qiang Guo, Song Zhao, Zhiqiang Liu, Ting Xiao, Yani Liu, Yinli Qiu, Yuanyuan Hou, Guisen Zhang, and KeWei Wang Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China (X.X., T.X., K.W.); School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China (Y.W.); Institute of Pharmaceutical Research, Jiangsu Nhwa Pharmaceutical Co., Ltd., Xuzhou, Jiangsu, People’s Republic of China (Q.G., S.Z., Z.L., Y.Q., Y.H., G.Z.); and Department of Downloaded from Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, People’s Republic of China (Y.L., K.W.) Received February 7, 2018; accepted March 28, 2018 ABSTRACT Multitarget antidepressants selectively inhibiting monoaminergic of treatment-resistant depression, whereas imipramine jpet.aspetjournals.org transporters and 5-hydroxytryptamine (5-HT) 2A receptor have (30 mg/kg, by mouth) and duloxetine (30 mg/kg, by mouth) demonstrated higher efficacy and fewer side effects than showed no obvious effects.
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