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NIH Resources for Translational Neuroscience

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NIH Resources for Translational Neuroscience Disease Tools & Assay Lead Target ID HTS Hit to Lead Pre-Clinical Ph. I Ph. II Ph. III Ph. IV Target Development Optimization Pipeline Opportunity Description Active Links Contact Information NIDA Drug Supply Program Program provides chemicals and research probes that are http://www.drugabuse.gov/researchers/research- Rik Kline either unavailable, difficult to obtain, or very expensive to buy resources/nida-drug-supply-program Disease Target (DSP) Phone: (301) 827-5243 to researchers. Collection of early 800 items including [email protected] stimulants, sedatives/hypnotics, hallucinogens, cannabinoids, phencyclidines, designer drugs, opioid agonists and antagonists, nicotine analogs, radio- and mass-labeled analogs, opioid peptides, marijuana, standardized nicotine or THC cigarettes, and standardized drug solutions and dosage forms. NIH NeuroBiobank (NBB) Repository of human post-mortem brain tissue and related https://neurobiobank.nih.gov/ Disease Target biospecimens spanning neurological, neuropsychiatric and [email protected]. neurodevelopmental diseases Target ID Harvard Brain Tissue Repository of postmortem brain specimens from neurologically http://www.brainbank.mclean.org/ http://www.brainbank.mclean.org/about/contact/ Disease Target Resource Center impaired individuals and controls Phone: 800-272-4622 Target ID Human Brain and Spinal Fluid Repository of pre- and post-mortem brain, spinal cord, http://brainbank.ucla.edu/ May Wong, Ph.D. Disease Target Resource Center (HBSFRC) cerebrospinal fluid, serum, blood cells and urine for research Phone: (301) 496-1431 on nervous system disorders [email protected] Target ID [email protected] National NeuroAIDS Tissue Repository of brain, spinal cord, cerebrospinal fluid, blood, and https://www.nntc.org/ May Wong, Ph.D. Disease Target Consortium (NNTC) other tissue samples from HIV-infected individuals Phone: (301) 496-1431 [email protected] Target ID NICHD Brain and Tissue Bank Repository of brain and other tissues for research on http://medschool.umaryland.edu/btbank/ Phone: 1-800-847-1539; 410-706-1755 Disease Target for Developmental Disorders developmental disorders [email protected] Target ID NINDS National Brain and Repository of donated human post-mortem brain tissue and http://www.ninds.nih.gov/research/parkinsonsweb/brai Thomas Beach, M.D., Ph.D. Disease Target Tissue Resource for related biospecimens from people with Parkinson's disease n_banks/U24_BSHRI.htm Phone: 623-832-6528; 623-832-5643 Parkinson’s Disease and (PD), Alzheimer's disease (AD) and other neurological [email protected] disorders Target ID Related Disorders (NBTR-PD) at the Banner Sun Health Research Institute (BSHRI) Repository of donated human post-mortem brain tissue from http://www.nybb.hs.columbia.edu/ Columbia University: New Phone: 212-305-2299 Disease Target people with psychiatric and neurological disorders for York Brain Bank [email protected] research, neuropathological evaluation and diagnosis Target ID Johns Hopkins Brain Repository of donated postmortem human brains from people http://www.nybb.hs.columbia.edu/ Olga Pletnikova, Ph.D. Disease Target Resource Center with Parkinson's disease. [email protected] Target ID Juan Troncoso, Ph.D. [email protected] National Institute of Mental Program helps to synthesize, purify, and distribute otherwise https://nimh-repository.rti.org/ Jamie Driscoll Disease Target health (NIMH) Chemical unavailable essential compounds to stimulate basic and Phone: (301) 443-3636 Synthesis Program clinical research in psychopharmacology relevant to mental [email protected] Target ID health and in areas such as the molecular pharmacology and signaling of CNS receptors, longitudinal studies to evaluate the Tools & Assay Dev. molecular, biochemical, and behavioral actions of psychoactive compounds, and functional brain imaging in both primates and humans. NIA National Cell Repository Banks of DNA and cell lines from families with multiple http://ncrad.iu.edu/ [email protected] Disease Target for Alzheimer's Disease individuals affected by Alzheimer's disease or related diseases (800) 272-3900 Target ID (NCRAD) Tools & Assay Dev. NIH Repositories at Banks DNA and cell lines from individuals diagnosed with https://hopecenter.wustl.edu/?page_id=1408 E-mail: [email protected] Disease Target Washington University, St. substance abuse disorders or with extensive family histories of alcoholism. Phone: (314) 273-1730 Target ID Louis Fax: (314) 362-2244 Tools & Assay Dev. NIH Repositories at Coriell Banks cells and DNA from individuals with neurological https://catalog.coriell.org/ Roderick Corriveau, Ph.D. Disease Target Institute desiases (Parkinson's disease, stroke, epilepsy and motor), Phone: (301) 496-5680 inherited mental diseases, premature aging syndromes, and [email protected] Target ID Alzheimer's disease. Email [email protected] Tools & Assay Dev. Phone (856) 757-4848 NIMH Center for Collaborative Banks of clinical data, cell lines and DNA from affected and https://www.nimhgenetics.org/ Sue Winkeler Disease Target Genetic Studies on Mental unaffected individuals in families with Alzheimer's disease, [email protected] Disorders autism, bipolar disorder, depression, schizophrenia and other Target ID disorders [email protected]. Tools & Assay Dev. Parkinson’s Disease Banks of longitudinal human biospecimens(plasma, serum, http://pdbp.ninds.nih.gov/ Scott Kaiser Disease Target Biomarkers Program (PDBP) DNA, RNA, and CSF) and associated data from Parkinson's Email: [email protected] and control subjects for use in Parkinson's Disease Phone: 317-278-0594 Target ID Biomarkers discovery projects. https://pdbp.ninds.nih.gov/contact-us Tools & Assay Dev. NIH Human Embryonic Stem Resource to obtain human embryonic stem cell lines that are https://stemcells.nih.gov/contact-us.htm [email protected] Disease Target Cell Registry eligible for use in NIH-supported research Target ID Tools & Assay Dev. Tulane Center for Stem Cell Center provides well characterized human adult stem cell https://medicine.tulane.edu/centers-institutes/ Disease Target Research and Regenerative preparations and core facility service to academic researchers stem-cell-research-regenerative-medicinehttps:// Medicine worldwide. medicine.tulane.edu/centers-institutes/stem-cell- Target ID research-regenerative-medicine Tools & Assay Dev. Center provides customized, large scale, cell culture services National Cell Culture Center https://www.niaid.nih.gov/about/irf-cell- Disease Target for basic research laboratories. https://www.niaid.nih.gov/about/integrated- culture-core-lab research-facility-chief-scientist-contacts Target ID Tools & Assay Dev. NIA Genetics of Alzheimer's National genetics data repository facilitates access of https://www.niagads.org/ [email protected] Disease Target Disease Data Storage genotypic data to qualified investigators for the study of the [email protected] genetics of late-onset Alzheimer's disease. Target ID (NIAGADS) Tools & Assay Dev. Gene Expression Nervous Gene expression atlas of the developing and asult central http://www.neuroscienceblueprint.nih.gov/factSheet/G Laura Mamounas, Ph.D. Disease Target System Atlas (GENSAT) nervous system in the mouse. GENSAT also generates ENSAT.htm Phone: (301) 496-5745 availible CAC_EGFP reporter and BAC-Cre recombinase [email protected] driver lines (cell and mouse) to serve as tools for cell-specific www.gensat.org genetic manipulations in the nervous system. Pre-Clinical Mouse Genome Informatics International database resource for the laboratory mouse, http://www.informatics.jax.org/ http://www.informatics.jax.org/mgihome/support/ Disease Target providing integrated genetic, genomic, and biological data to mgi_inbox.shtml facilitate the study of human health and disease. Pre-Clinical Deltagen and Lexicon Trans-NIH mouse initiatives to access to 251 lines of knockout Colin Fletcher, Ph. D. Disease Target mice that have been extensively characterized. https://www.mmrrc.org/about/Deltagen- Phone: (301) 451-1340 Knockout Mice and Lexicon_links.php Phenotypic Data [email protected] Pre-Clinical Cre-Driver Network Resource to acess more than 100 novel Cre Driver mouse http://www.neuroscienceblueprint.nih.gov/factSheet/C Andrea C. Beckel-Mitchener, Ph.D. Disease Target lines, available along with a recombinase-expression profile reDriver.htm Phone: (301) 443-5288 for each line. Mouse strains are suitable for tissue- and time- [email protected] specific perturbation of gene function in the nervous system. Pre-Clinical Mutant Mouse Regional Resource provides central archiving, quality control, and https://www.mmrrc.org/ [email protected] Disease Target Resource Centers (MMRRCs) distribution of mouse strains and mouse embryonic stem cell Phone: 800-910-2291 lines. Pre-Clinical NIH Deltagen and Lexicon Contract resource to access more than 250 lines of knock-out Colin Fletcher, Ph. D. Disease Target mice and associated phenotypic data from the private https://www.mmrrc.org/about/Deltagen-Lexicon_l Phone: (301) 451-1340 Knockout Mice and inks.php Phenotypic Data Resource collections of Deltagen and Lexicon [email protected] Pre-Clinical The Jackson Laboratory Repository of mouse strains and mouse ES cell lines for http://www.jax.org/index.html http://www.jax.org/index.html Disease Target (JAX) research. JAX offers various mouse models of neurological diseases and spontaneous genetic mutations. Pre-Clinical
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