2020 ANNUAL REPORT Grayson-Jockey Club Research Foundation WHERE THE DOLLARS GO 60 34 projects 54 projects projects Track Surface Respiratory Reproduction & Miscellaneous $3.077 $3.623 $3.855 million million million

88 28 124 projects projects projects Musculoskeletal Laminitis Infectious Disease $7.023 $2.036 $9.812 million million million

Funding over $29.1 Million on 384 Projects at 45 Institutions

The process of moving bench-top research to clinical practice can take a long time. In humans it can take easily over a decade to get the research out of the lab and into a clinical setting. We are fortunate to have the Grayson-Jockey Club Research Foundation“ “available to help researchers transfer new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy and prevention. Without the generosity of the foundation research on infectious diseases would not have been possible in a clinical setting.

Nathan Slovis DVM, Dipl. ACVIM Director McGee Medical Center Hagyard Equine Medical Institute TABLE OF CONTENTS

Directors & Officers 2 History 3 Year in Review 4 Research Advisory Committee 6 Funded Projects in 2020 8 The Cycle of a Grant 11 Focused Research 12 Donors 13 Membership Levels inside back cover Tax Status inside back cover

Directors & Officers 2 Board of Directors

Dell Hancock Rick Arthur, DVM A. Gary Lavin, VMD Chairman Perry Bass Braxton Jones Lynch Kevin Lavin Larry R. Bramlage, DVM Leverett Miller Vice Chairman Charlsie Cantey John M. B. O’Connor Adele B. Dilschneider John C. Oxley Donald Dizney Hiram C. Polk, MD

William S. Farish Jr. Daisy Phipps Pulito Lucy Young Hamilton Geoffrey Russell Joseph W. Harper Virginia Guest Valentine

Stuart S. Janney III

Officers & Staff Jamie S. Haydon Holly E. White President Director of Development

Resia L. Ayres Shannon Kelly Secretary, Operations Manager Development Manager

Laura Barillaro Johnny Mac Smith, DVM Treasurer Veterinary Consultant

History 3

The original Grayson Foundation was formed in 1940 and named In 1993, the foundation received another major gift when Paul RESEARCH HIGHLIGHTS SINCE 1940 in honor of Admiral Cary Grayson who was the personal physician Mellon donated the $1 million bonus that his Kentucky Derby First Equine Influenza Vaccine to President Woodrow Wilson and the chairman of the American winner Sea Hero won in the Chrysler Triple Crown Challenge. Virus Abortion Vaccine Red Cross, as well as a horseman himself. The foundation’s first Mr. Mellon requested that double that amount be raised in grant was made as a $1,000 donation to the University of Pennsylvania response, and this endowment drive was successfully concluded Equine Infectious Anemia Study School of Veterinary Medicine to continue its work on periodic ophthalmia. during the 1995/96 fiscal year. The $1 million was double-matched, Development Of The Field Of Biomechanics as members of The Jockey Club and other contributors donated Defined The Cause Of Colitis X From the beginning, the aim was to support research at existing more than $2 million. Mellon passed away in 1999, leaving $2.5 institutions through funding rather than carry out the research million to the foundation’s endowment. In 2000, the foundation Control Of The Shaker Foal Syndrome itself. William Woodward Sr, chairman of The Jockey Club, stated created the Rokeby Circle as the designation for those who Defined Nature Of Wobbler Syndrome that the formation of the foundation is "the result of the conviction contribute $10,000 or more in a given year. Rokeby is the name Equine Viral Arteritis Vaccine of a large number of persons devoted to the raising and breeding of Mr. Mellon's beloved Virginia estate. of horses that there is a positive need for further research in Study Of Risk Of Injury From Front Toe Grabs In 2004, the Oxley Challenge was initiated. Under the direction veterinary medicine and in the breeding, raising, and handling of Equine Protozoal Myeloencephalitis Study horses." In 1940, the horse and mule were still deeply involved in of foundation board member John C. Oxley, his family’s Oxley military defense, and the scope of the foundation's efforts went foundation pledged $1 million over four years contingent on the Gene Therapy For Equine Arthritis far beyond the Thoroughbred, to all breeds, although the impetus foundation’s raising a like amount from new income sources. Cause And Diagnosis Of Placentitis In Mares The Foundation was successful in that match, and so received came from leaders in Thoroughbred racing. Over nearly a half- New Vaccination Approaches Against R. Equi Pneumonia century, the Grayson Foundation operated as a separate entity, $250,000 from the Oxley Foundation in each of four years. fulfilling the purposes of its founders despite constant limitations Muscular Factors Influencing Airway Size In Exercising In collaboration with The Jockey Club, the foundation coordinated on available funding. Dietary Implications For Colon Impaction and underwrote the first Welfare and Safety of the Racehorse Equine Viral Arteritis Vaccine The Jockey Club created a research foundation in 1984, and five Summit (summit) in 2006. That meeting, and a second gathering years later this was merged with the Grayson Foundation, to be of industry experts in 2008, generated a number of recommendations New Protocols For Alleviating Buck Shins that the industry has embraced to a large extent. The Jockey known since then as the Grayson-Jockey Club Research Foundation, Study Of Bacteria Associated With MRLS Inc. (GJCRF, the Foundation). The merger has been fruitful in the Club’s Thoroughbred Safety Committee endorsed recommendations Studies Of Immunity To EPM funding of scientific advancements and the fundamental health of of the summit, and the National Thoroughbred Racing Association’s horses and in recent years it has been able to disperse more than Safety and Integrity Alliance program is based in part on those Developing “Physiological Trim” Promoting Healthy Hooves recommendations. Also, the Equine Injury Database, which is $1 million annually in grants. Laminitis Study Leading To Cryrotherapy Treatment Protocols designed to provide the industry much needed epidemiological Over the years there have been several major donors who were analysis of trends, aimed at improving injury rates nationally, Initiated Primary Work On Piroplasmosis instrumental in enhancing the success of the foundation in fulfilling evolved from the summit. All additional summits have been held EIPH Study at Keeneland, in 2010, 2012, 2014, 2015, 2016 and 2018. In 2020 its mission. In 1991, the Robert J. Kleberg and Helen C. Kleberg PET Scan Project Foundation donated $2 million to Grayson-Jockey Club Research the summit was held as a webinar. Foundation. Mr. Kleberg had studied genetics and as head of King Messenger RNA Molecule to Treat Rhodococcus equi Grayson reached a milestone for funding more than $1 million in Ranch, developed the Santa Gertrudis breed of cattle. He also was Bisphosphonate Research instrumental in development of the American Quarter Horse and research for the first time in 2007, and 2020 is the sixth-straight the list of many excellent Thoroughbreds he bred includes 1946 year that more than $1 million has been approved. Triple Crown winner Assault. Year in Review 4

Since 1940, Grayson-Jockey Club Research Foundation The Tribute program continued to see growth in 2020, The May 26 webinar featured Dr. Mick Peterson, executive has been a leading source of private funding for equine and the foundation introduced a new Heritage Society director of the Racing Surfaces Testing Laboratory and medical research that benefits all breeds of horses. designed to assist donors with making planned giving professor of Biosystems and Agricultural Engineering at The year 2020 proved to be challenging, but the decisions. the University of Kentucky. Dr. Peterson focused on the foundation continued its commitment to fund significant Maintenance Quality System, which monitors track conditions. equine research at institutions worldwide. His presentation also included interviews with Glen Kozak, the New York Racing Association’s senior vice Research president of Operations & Capital Projects; Jim Since 2006, in collaboration with The Jockey Club, the Pendergest, general manager of The Thoroughbred Center In 2020, the board authorized expenditure of $1,389,637 foundation coordinated and underwrote the Welfare and director of Surfaces at Keeneland; Dr. Stephanie to fund 17 new projects at 13 universities, four continuing and Safety of the Racehorse Summit (summit), gathering Bonin, biomedical engineer at MEA Forensic; and Dennis projects, and the Storm Cat Career Development Award. industry experts to generate recommendations in the Moore, track superintendent at Del Mar and Santa Anita. One of the projects funding the sample collection, industry. Eight summits have been held at Keeneland. storage, and cataloging of tissue related In lieu of an in-person event in 2020 due to the impact The fourth webinar was moderated by Dr. Jennifer to nocardioform placentitis for future of the COVID-19 pandemic, Grayson hosted a series of Durenberger, The Jockey Club steward for NYRA, on submitted research, was accepted weekly online seminars on equine health and safety topics. June 2. This session featured a presentation by Dr. Sue because it directly affected the 2020 Stover, professor of Surgical and Radiological Sciences Kentucky foal crop. The virtual Welfare and Safety of the Racehorse Summit at UC Davis School of Veterinary Medicine. Stover delved kicked off May 12 with a presentation by Dr. Katherine into findings from the California Horse Racing Board’s The foundation also filled the special call for detection of Garrett of Rood & Riddle Equine Hospital, who discussed postmortem program. She noted that catastrophic bisphosphonates in Thoroughbreds with two grants: the uses and advantages of different imaging modalities. injuries are the result of pre-existing conditions and tend Vinnie and Teresa Viola’s St. Elias Stables’ project She also highlighted common injuries to the fetlock. to occur in predictable locations. submitted by Dr. Heather Knych at the University of California-Davis and a project from Cornell University On May 19, Dr. Dionne Benson, chief veterinary officer The last presentation was delivered by Dr. Tim Parkin, submitted by Dr. Heidi Reesink which received of The Stronach Group, moderated a panel consisting of professor of Veterinary Epidemiology at the University support from the Racing Medication and Testing Dr. Ryan Carpenter, a private veterinarian in California; of Glasgow, and the webinar was moderated by Consortium (RMTC) and the Klein Family Foundation. Dr. William Farmer, the equine medical director for Dr. Mary Scollay, executive director and chief operating Churchill Downs Incorporated; and Dr. Scott Palmer, officer of the RMTC. Parkin described risk factors for Membership and Development the equine medical director for the New York State fatal injury in Thoroughbred racehorses based on data Through the horsemen’s bookeeper at each track, jockeys Gaming Commission. The group emphasized the from the Equine Injury Database. Risk factors included can donate $1 from each mount to the importance of transparency in medical records history of previous injury, time spent on the vet’s list, foundation. More than $15,000 in support throughout a horse’s racing career. increased age at first start, changing trainers and time came from jockeys who participated spent with a trainer, track surface and condition, race from the following venues California distance, and racing in claiming races. Racing Fairs, Del Mar Thoroughbred Club, Delaware Park, Gulfstream Park, Keeneland, Los Alamitos Race Course, Oaklawn Racing Casino Resort, Prairie Meadows, Remington Park, Santa Anita Park and Zia Park. 5

Sponsorship and Education Dr. Ben Sykes at Massey University presented Grayson partnered with several In May the foundation was highlighted on Thursday information on equine gastric ulcer syndrome in the groups to create a series of Night Live on America’s Best Racing (ABR). ABR’s Dan fourth webinar while Dr. Arthur Frampton of University handicapping events in 2020 Tordjman and Penelope Miller interviewed Dr. Andrew of North Carolina- to raise donations and awareness. Van Eps, professor at the University of Pennsylvania, Wilmington reviewed and Dr. Sara Langsam, veterinarian at Teigland, Franklin equine herpes virus in The “Grayson Grass Challenge,” and Brokken DVM, in a webinar about laminitis along the fifth chat. sponsored by Indiana Grand Racing with foundation president, Jamie Haydon. & Casino, was a five-week handicapping contest The final webinar in 2020 spanning August 10- September 7, in which participants Many scheduled events and sponsorships were featured Dr. Noah Cohen of Texas A & M University submitted selections on two specified turf races each disrupted in 2020. The foundation had been named and Dr. Jeroen Pollet of Baylor College of Medicine, week. Indiana Grand provided each contestant $100 to the charity for the 2020 Land Rover event, which who presented information on rhodococcus equi and wager on specific races. At the end of the five weeks, was cancelled. Other events were postponed as well, treating it with inhalation therapy. nearly $4,000 of the remaining bankroll plus winnings but Grayson was able to participate in some events: from the contestants went to Grayson. The United States Dressage Festival of Champions, The National Horse Show, The Palomino Horse Marketing and Awareness On Sunday, October 25, 11 two-member teams Breeders’ Association World Championships and To further our mission and expand awareness of the participated in the 1/ST Charity Handicapping Challenge. The AQHA Kentucky Fall Classic World Show. foundation, Grayson engaged Wrigley Media to Sponsored by Santa Anita Park, $4,500 was raised for produce a commercial that is shown at horseshows, the foundation. during racing broadcasts, and at other equine-related events. Both a 30-second and 60-second commercial Little Red Feather Racing and Equibase Company were created. participated in the “Gamble for Grayson Handicapping Challenge.” This contest held on November 28-29, The foundation also found ways to promote our The Research Spotlight was produced twice in 2020, spanned five graded stakes races held that weekend at message by creating a new VET Chat series. with the spring newsletter published in the April Del Mar Thoroughbred Club and raised over $2,600 for The hour-long webinars began with Dr. Stephen edition of BloodHorse magazine. Grayson also Grayson. Reed of Rood & Riddle Equine Hospital who continued to contribute articles to the magazine’s discussed equine protozoal myeloencephalitis monthly Health Zone. The foundation’s online Despite the cancellation of the Elizabeth Locke jewelry and wobbler syndrome. newsletter, Equine Research News, published trunk show, held annually at Keeneland during the the 12th annual Stallion Durability and Soundness Keeneland September Yearling Sale, Elizabeth Locke The second webinar in the series featured Drs. Statistics. Grayson also produced two special Jewels held an online version and once again Anthony Blikslager and Amanda Ziegler of North research updates on laminitis and colic. donated a percentage of the proceeds to Grayson. Carolina State College of Veterinary Medicine, who talked about colic. While in the next webinar, Dr. Lauren Schnabel of North Carolina State University discussed therapeutic use of stem cells for tendon and ligament injuries.

Research Advisory Committee 6

The Research Advisory Committee evaluates research proposals and advises the Foundation’s board of directors on the basis of the needs of the industry and scientific quality of each project. RAC For the 2020 grants allocation, the committee was composedof the following persons who 2020 served the Foundation without compensation.

Chairman Amanda Adams, DVM, PhD Daryl Bonder, DVM Stephen Reed, DACVIM Immunologist, Gluck Equine Research Center Private Practice Equine Surgery and Sports Medicine Internal Medicine & Shareholder, Rood & Riddle Equine University of Kentucky • Lexington, KY Toronto Equine Hospital • Toronto, ON Canada Hospital; Graduate - University of Kentucky Graduate - Ontario Veterinary College, Emeritus Professor, The Ohio State University and University of Guelph Adjunct Professor, Gluck Center, University of Kentucky Scott Bailey, DVM, DACT Rood & Riddle Equine Hospital • Lexington, KY Associate Professor, Theriogenology Etta Bradecamp, DVM, Dipl.ACT, Dipl, ABVP Graduate - The Ohio State University North Carolina State University • Raleigh, NC Theriogenology and Equine Practice Graduate - Kansas State University Rood & Riddle Equine Hospital • Lexington, KY Consultant Graduate - Auburn University Johnny Mac Smith, DVM Jennifer Barrett, DVM, PhD, DACVS, ACVSMR Founding Partner Theodora Ayer Randolph Professor of Equine Surgery Steven Brinsko, DVM, PhD Peterson & Smith Equine Hospital • Ocala, FL Virginia Tech, Marion duPont Scott Equine Med. Center Professor & Associate Department Head for Academic Graduate - Auburn University Leesburg, VA Programs, Graduate - Cornell University Theriogenologist Members of the Board of Directors Texas A & M • College Station, TX Rick Arthur, DVM Warwick Bayly, BVSc MS PhD DACVIM Graduate - University of Florida Equine Medical Director Internal Medicine and Exercise Physiology California Horse Racing Board • Sierra Madre, CA Washington State University • Pullman, WA Carol Clark, DVM, Dipl, ACVIM Graduate - University of California, Davis Graduate - Washington State University Private Practice Peterson & Smith Equine Hospital • Ocala, FL Larry Bramlage, DVM, MS, DACVS Alicia Bertone, DVM, PhD, DACVS, ACVSMR Graduate - Texas A & M Surgeon and Shareholder The Trueman Chair in Equine Clinical Medicine& Surgery Rood & Riddle Equine Hospital • Lexington, KY The Ohio State University • Columbus, OH Michele Coleman, DVM, ACVIM, PhD Graduate - The Ohio State University Graduate - Cornell University Epidemiology, Infectious Disease, Clinical and Research Texas A & M • College Station, TX A. Gary Lavin, VMD Jeff Blea, DVM Graduate - University of Georgia Private Practice Racetrack Practitioner Louisville, KY Von Bluecher, Blea, Hunkin Inc. • Sierra Madre, CA Graduate - University of Pennsylvania Graduate - Colorado State University

7

J. Barry David, VMD, PhD, DACVIM Christopher Kawcak, DVM, PhD, DACVS Heidi Reesink, VMD, ACVS, PhD Associate Professor of Orthopedics Comparative Biomedical Sciences Researcher Hagyard Equine Medical Institute • Lexington, KY Colorado State University • Fort Collins, CO Former Storm Cat Award Recipient Graduate - University of Pennsylvania Graduate - Colorado State University Cornell University • Ithaca, NY Graduate - University of Pennsylvania Carrie Finno, DVM, PhD, DACVIM Heather Kynch, DVM, PhD, DACVCP Assistant Professor and Researcher Associate Professor of Clinical Veterinary Pharmacology Brett Sponseller, DVM, PhD, Dipl. ACVIM University of California, Davis • Davis, CA University of California-Davis • Davis, CA Associate Professor Graduate - University of Minnesota Graduate - University of California-Davis Iowa State University • Ames, IA Graduate - Cornell University Kelsey Hart, DVM, PhD, DACVIM (LAIM) Sara Langsam, VMD Associate Professor, Large Animal Internal Medicine Private Practice Ramiro Toribio, DVM, MS, PhD, ACVIM University of Georgia • Athens, GA Teigland, Franklin, and Brokken • Elmont, NY Clinician/Researcher, Endocrinology & Internal Medicine Graduate - Cornell University Graduate - University of Pennsylvania The Ohio State University • Columbus, OH Graduate - Universidad Nacional de Rio Cuarto (Honors) Scott Hay, DVM Mathilde Leclère, DVM, PhD, DACVIM (LAIM) Private Practice Assistant Professor Regina Turner, VMD, PhD Teigland, Franklin and Brokken • Fort Lauderdale, FL University of Montreal • Montreal, QU Canada Theriogenologist Graduate - Kansas State University Graduate - University of Montreal University of Pennsylvania • Kennett Square, PA Graduate - University of Pennsylvania Jorge Hernandez, DVM, MPVM, PhD Ernie Martinez, DVM Epidemiologist- Disease Diagnostics Private Practice Andrew Van Eps, BVSc, PhD University of Florida • Gainesville, FL Hagyard Medical Institute • Lexington, KY Associate Professor Graduate - University of Baja California Graduate - Oklahoma State University University of Pennsylvania • Kennett Square, PA Graduate - The University of Queensland Susan Holcombe, VMD, MS, PhD, DACVS, DACVECCMargaret Mudge, VMD, DDACVS, DACVECC Professor Associate Professor Michigan State University • East Lansing, MI The Ohio State University • Columbus, OH Graduate - University of Pennsylvania Graduate - University of Pennsylvania

Jennifer Janes, DVM, PhD, Dipl. ACVP Grayson has funded Assistant Professor of Anatomic Pathology over $1 million in University of Kentucky • Lexington, KY grants each year Graduate - University of Tennessee for the last 6 years.

Funded Projects in 2020 8

The board of directors of Grayson-Jockey Club Research Foundation has authorized expenditure of $1,506,764 to fund 18 new projects at 13 universities, four continuing projects, and the Storm Cat Career Development Award.

NEW PROJECTS Enhancing The Efficacy Of MSCs For Tendon Healing Lauren Schnabel, North Carolina State University Passive Immunization Of Foals With This proposal examines the tendon inflammatory environment RNA-AB Against R Equi following acute injury and the effect of such an environment on Jeroen Pollet, Baylor College Of Medicine mesenchymal stem cells (MSCs), with the goal of improving MSC By inhalation therapy, we intend to deliver the treatment efficacy. genetic code for a protective antibody against rhodococcus equi into the lung cells of newborn AMPK Agonist Combination Therapy & ID In Horses foals, to rapidly protect them against infection. Teresa Burns, The Ohio State University By completing this work, we hope to characterize a combination Improving Fungal Diagnosis In Horses therapy to improve equine insulin resistance that is administered Soon Hon Cheong, Cornell University orally and well tolerated. Developing a diagnostic test that can rapidly detect, identify, and determine the antifungal susceptibility profile of clinical SDFT Adaptation In Thoroughbred Racehorses equine samples to improve treatment outcomes of fungal Sushmitha Durgam, The Ohio State University infection in horses. The impact of training and racing on University The Ohio State Courtesy Dr. Nong Inpanbutr, Nong Inpanbutr, Courtesy Dr. (mal)adaptations in superficial digital flexor Bisphosphonates And Fatal Musculoskeletal Injury tendon hierarchical structure will be evaluated Heidi Reesink, Cornell University to delineate the pathophysiology of this Determining the prevalence of bisphosphonate use in common injury in racehorses. racehorses and whether bisphosphonates are associated with fatal musculoskeletal injury is essential to equine welfare Dynamics Of Vitamin D In Hospital Foals and the future of racing. Ramiro Toribio, The Ohio State University additional funding for this project from Klein Family Foundation & RMTC Critically ill foals often have low blood levels of vitamin D; the goal is to investigate if their levels Novel Treatment For Recurrent Exertional Rhabdomyolysis over time are associated with the severity of their Stephanie Valberg, Michigan State University disease and mortality. Determining if a potent antioxidant coenzyme q10, not subject to withdrawal times, can benefit horses with tying up by replenishing diminished muscle coq10 levels and decreasing oxidative stress.

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Asthma, Performance And Omega-3s In Racing Thoroughbreds Effect Of NSAIDs On Anion Transport In The Equine Colon Laurent Couetil, Purdue University David Freeman, University of Florida Investigating the variability of asthma severity in horses This proposal is designed to improve management of horses with racing across the United States, its effect on performance right dorsal colitis, an insidious life-threatening form of colic for and determine if omega-3 pufa supplementation is beneficial. which all horses on phenylbutazone are at risk.

Anti-Pnag Plasma For Preventing Protein Based In Vivo Diagnostic For Endometrial Biofilm R. Equi Foal Pneumonia Mats Troedsson, University Of Kentucky Noah Cohen, Texas A&M University Successful management of bacterial biofilms in the uterus requires Transfusion of plasma is the only licensed an accurate diagnostic in vivo assay that we propose to develop. product for preventing rhodococcus equi pneumonia, and demonstrate that we have Novel Delivery Of Antimicrobials Into Equine Joint developed a plasma product superior to Simon Bailey, Universityof Melbourne that available currently. The development and testing of, a novel (gel) carrier formulation for the antibiotic Cefuroxime, Effect Of Nebulized Lidocaine In Treating Equine Asthma injection into horses’ joints for application Melissa Mazan, Tufts University as a treatment of jointinfections. Evaluating the efficacy of inhaled lidocaine in equine asthma in Diagnostic Assay For Recurrent Exertional reducing airway inflammation Rhabdomyolysis and hyper-responsiveness by Molly McCue, University Of Minnesota promoting an anti-inflammatory Identify a comprehensive set of genetic markers that allow RER risk lung environment. Courtesy Jamie Kaj Norris, prediction before horses tie-up and preemptive management to University of Kentucky decrease the frequency and severity of clinical disease. Bisphosphonate Effects on Biomarkers Sponsored by Heather Knych, University of California-Davis This study will allow for development of Inhibiting EHV-1 With Anti-Inflammatory Drugs sensitive and alternate methods for Arthur Frampton, University Of N.Carolina Wilmington detection of bisphosphonates. Using a tissue culture model system to test the ability of specific drugs to reduce the damaging hyper-inflammatory response Funded by that is observed in EHV-1 infected horses suffering from equine herpesvirus myeloencephalopathy (EHM).

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Nocardioform Placentitis Non-Invasive Evaluation Of Host-Microbiota Interactions University Of Kentucky Canaan Whitfield-Cargile, Texas A&M Sample collection and storage of tissue This study aims to develop a non-invasive for future research and platform to serve as a diagnostic test for testing for nocardioform placentitis. gastrointestinal inflammation prior to severe disease and to reveal how bacteria CONTINUING PROJECTS in the gut influence horse health.

Training Programs For Prevention Of Fetlock Injury Sue Stover, University of California-Davis Predicting proximal sesamoid bone fracture in racehorses from a calibrated computational model that incorporates training programs, 2020 CAREER DEVELOPMENT AWARD track surface properties, and bone’s reparative processes. A single Storm Cat Career Development Award was given in 2020. Sponsored by The first award in 2006 was a $15,000 grant designed to encourage an individual considering a career in equine research. It is underwritten annually by Mrs. Lucy Young Hamilton, a GJCRF board member whose family stood the champion stallion Antimicrobial Properties Of Equine MSCS Storm Cat at Overbrook Farm. This year’s award winner is: Laurie Goodrich, Colorado State University This study is expected to impact the equine industry by validating Sherry Johnson TLR activated equine mesenchymal stem cells as an effective, Colorado State University novel therapy in treating multi-drug resistant infections. She is currently working with Dr. Melissa King, (the 2009 Storm Cat Award recipient) an assistant professor of Equine Sports Robotic CT For Assessing Of Bone Morphology Medicine & Rehabilitation at CSU, on the project Kyla Ortved, University of Pennsylvania “Validation of Blood Flow Preventing catastrophic injuries in the Thoroughbred racehorse: Restriction Training in Horses.” screening fetlock joints using standing robotic CT and biomarker analysis.

Sponsored by

Courtesy Jamie Kaj Norris, University of Kentucky The Cycle of a Grant 11

Drs. Gary Lavin and Larry Bramlage reorganized the foundation’s process of evaluating grants in 1999. Instead of having separate committees of academicians and practicing veterinarians, a single Research Advisory Committee (RAC) was created. The RAC includes 32 individuals representing various research specialties and veterinary practices from across North America. The RAC convenes in January to evaluate all proposals submitted by the research community, spending three days poring over the projects, rating them and recommending the best to the board of directors who determines how many projects can be funded in that year.

Application There is a multi-layered review process for each Once grants are ranked numerically to ensure that Since 1999 the foundation has funded 384 grant starting with the identification of experts on each grant is ranked correctly for its strengths and grants, averaging more than $1.3 million annually the subject matter and potential conflicts of weaknesses, each grant is then compared to its in awards for the last six years. The average interests within the RAC. Each grant is initially neighboring grant. If a grant is moved in the ranking amount funded during the past six years has been assigned four reviewers. The reviewers it must be reassessed at each placing, compared to $109,645 per grant. For 2020, the foundation individually score the grant based on: its higher and lower neighbor, to ensure that the received 69 applications from 35 different (a) scientific approach placing is correct within the consensus of the group. institutions across eight countries. (b) overall impression (c) impact, Funding All applicants must comply with the regulations d) feasibility The recommendations of the RAC are presented pertaining to animal use in the proposed study, (e) budget to the board of directors for final review, with which is overseen by the INSTITUTIONAL ANIMAL Each grant is scored numerically and given a announcement of awards typically near the first week CARE AND USE COMMITTEE (IACUC). The IACUC written review. The RAC members assess and of March. The funding cycle commences April 1, must review and approve the research project read all applications prior to the review meeting. with three equal payments made through the year. prior to funding. In 2020 69 applications A timeline is incorporated into the application RAC Scoring averaging over document so that all investigators are aware of The RAC is a mix of 32 equine scientists and $109,645 the schedule. The applicant in the original per request practitioners capable of judging the merit of application predicts a schedule of progress. the most sophisticated proposals with clinical A progress statement is required on November 1 specialists from university clinics and private Final Review of the original funding year so that any problems practices. The group includes representation During the RAC meeting, the essential activities with the investigation are identified early and of the major clinical disciplines such as surgery, are to discuss each proposal with the entire adjustments can be made. Satisfactory progress internal medicine, and reproduction, along with committee and to rank the order for all acceptable must be documented in order to continue receiving the academic disciplines of pathology, immunology, proposals. The group endeavors to reconcile mean funding. microbiology, etc., with geographic diversity to scores between specialties to ensure that one reflect the importance of various local problems. discipline does not score significantly higher or Second-year funding must be approved by the lower than another discipline. foundation board following recommendations from the foundation office. Focused Research 12

The 2020 slate of research brings the Foundation’s totals since 1983 Universities to more than $29.1 million to underwrite 384 projects at 45 universities.

Auburn University Oregon State University University of Maryland Case Western Reserve Purdue University University of Melbourne Colorado State University Southern Illinois University University of Minnesota Cornell University Temple University University of Mississippi Harvard University Texas A&M University University of Missouri Iowa State University Tufts University University of North Carolina -Wilmington Kansas State University University of Bristol/UK University of Oklahoma Louisiana State University University of California-Davis University of Pennsylvania Ludwig Maximilian University / Germany University of Edinburgh/UK University of Queensland / Australia Massachusetts Institute of Technology University of Florida University of Saskatchewan / Canada Michigan State University University of Georgia University of Tennessee Mississippi State University University of Glasgow / UK University of Wisconsin North Carolina State University University of Guelph / Canada Virginia Tech University The Ohio State University University of Illinois Washington State University Oklahoma State University University of Kentucky

Currently there are Research results are published in peer-reviewed journals. 50 Open projects at All funded projects are scheduled for additional publications, 23 different institutions including those still with ongoing research, with 230 eligible On 3 continents projects for publication and 329 papers produced. Donors 13

* Donors whose contributions or portions thereof are designated as dues for membership shall have the privilege of participating in the annual election of directors. At the end of 2020, membership stood at 265 compared to 277 at the end of 2019. Names and addresses of members are maintained in the foundation's office at 821 Corporate Drive, Lexington, Kentucky 40503.

Special Friends of Grayson Recognizing donors whose generosity has created a profound impact on the foundation over the years and has been of extraordinary benefit to the horse. The Robert J. Kleberg, Jr. & Paul Mellon William Stamps Farish Fund Helen C. Kleberg Foundation The Oxley Foundation

Corporate Partners Churchill Downs * Kentucky Downs, LLC * Vincent Viola, The Viola Foundation * Great American Insurance * Oak Tree Racing Association * Keeneland Foundation * Mr. & Mrs. Kenny Troutt, WinStar Farm *

Rokeby Circle Named to honor of the generosity of the late Paul Mellon after his Virginia estate,Rokeby Farm. Donors at the $10,000-plus level within the year are members of the Rokeby Circle.

Joseph Allen, Allen Foundation * The Kingsbury Foundation * Carl Pollard * Perry Bass, The Perry R. Bass II Foundation * Klein Family Foundation Inc * Amanda Pope, John William Pope Foundation * Peter Brant * Krumpe Family Trust-Kathryne Krumpe Racing Medication & Testing Consortium, Inc. Alexander G. Campbell Jr. * Beau & Gail Lane * Rood & Riddle Equine Hospital * Isabelle H. de Tomaso * Dr. & Mrs. Gary Lavin * Mr. & Mrs. Barry Schwartz * Adele B. Dilschneider * Jacqueline B. Mars * Mrs. Maury Shields * Mr. & Mrs. Bertram R. Firestone * Robert E. Meyerhoff * Summer Wind Equine * Hugh A. Fitzsimons Jr. * Miller Charitable Lead Annuity Trust * Virginia G. Valentine * Lucy Y. Hamilton * Raymond & Elizabeth Montgomery * Margaret A. Weygand Dell Hancock * Celeste Neuman * William M. Backer Foundation * Seth & Debbie Hancock * Mr. & Mrs. John M.B. O'Connor * The William T. Young Foundation Inc. * Ian Highet * Mr. & Mrs. Paul F. Oreffice * Jockey Donations Audrey W. Otto * Mr. & Mrs. Summerfield K. Johnston Jr., Mr. & Mrs. John C. Oxley * The Tucker Foundation * Dr. Hiram C. Polk Jr. & Dr. Susan Galandiuk *

Platinum Circle Austin Lang Testamentary Trust Jaime Roth * Stella Thayer, Tampa Bay Downs * Donors 14 Gold Circle Josephine E. Abercrombie * Caroline Forgason * Louise & Leonard Riggio * Thomas W. Bachman * Hallway Feeds * Samantha Siegel * Ramona & Lee Bass Mr. & Mrs. Kevin S. Lavin * Mr. & Mrs. Michael Simpson * The Brian Ratner Foundation * Richard and Sue Ann Masson * Thoroughbred Charities of America Denali Stud, Inc. * Mike Ryan Bloodstock * USA Equestrian Trust, Inc Robert S. Evans, R.S. Evans Foundation, Inc. * Daisy Phipps Pulito * Silver Circle John & Jerry Amerman * Helen K. Groves * Pavla Nygaard * Laura Barillaro Hinkle Family Foundation * R. Alex Rankin * Dean Dorton * Indiana Grand Geoffrey G. Russell * Mr. & Mrs. C. S. Duncker * Kentucky Thoroughbred Farm Managers Club Santa Anita Park Elizabeth Locke Jewels Ambassador Earle I. Mack * Nancy C. Shuford * Equine Medical Associates, PSC * Anne P. McDowell * Ellis Starr Tracy Farmer * Jerry Moss * Gary Fenton, Little Red Feather Racing Roxy Nickels * Patron Helen C. Alexander * Dr. Claire Latimer Embertson * Bruce Lunsford * Dr. Rick M. Arthur * Dr. Rolf M. Embertson * John & Sally McAlister * James E. Bassett III * Equibase Company Joe Browne Nicholson * Betsy E. Bayha Mr. & Mrs. Joe T. Ford * J. Michael O'Farrell Jr. * Mark E. Bivins * Carl Hamilton The Perkins Charitable Foundation Dr. Chet Blackey DVM * Emory Hamilton * Dr. & Mrs. Frederick B. Peterson * Mrs. Cornelia W. Bonnie * John C. Harris * J. Kirk & Judy Robison * Mr. & Mrs. Samuel Boyte * Susan T. Harris * Mr. & Mrs. Alexander Scovil * James C. Brady * Jamie Haydon * Mr. & Mrs. A. J. C. Smith * Frank Brothers * Clement Hirsch Jr. * Speedway Stables * Mr. & Mrs. Darrell Brown * Steven & Diana Holland * George Strawbridge Jr. * Michael K. and Joan K. Burke * Jody & Michelle Huckabay * Mary Sullivan * Charlsie Cantey * G. Watts Humphrey Jr. * Sullivan Family Charitable Fund Mark W. Cheney * Orrin Ingram, The Community Foundation Jack Swain * Stephanie S. Clark of Middle Tennessee * Robert Tufts * Kyle W. Cooper * Stuart S. Janney III * Arnold B. Zetcher * Sandy Z. DuBose * William M. Lear Jr. * Linda C. Elliott * Kim and Laura Little * 15 Supporting Madeline Auerbach * Kerry B. Fitzpatrick Mr. & Mrs. Nick Nicholson * John H. Barr * Mr. & Mrs. James E. Friess * Rosendo & Cheryl Parra * Mr. & Mrs. Clifford Barry * Ben & Mary Wis Haggin * Alan Quartucci * Mr. & Mrs. Michael Baum * Arthur & Staci Hancock III * Dr. Stephen M. Reed * Gary Biszantz * Walker Hancock * Tom and Missy Robbins * Dr. Steven Brinsko * Charles Hayward * Walt Robertson * Donna Brothers * Jane E. Howard * Sayre Agency, Inc. * Cambus-Kenneth Farm, LLC * Annie Jones * Mr. & Mrs. Peter G. Schiff * Melissa Cantacuzene * Hope H. Jones * James Shircliff * Christiana Stables LLC * Brad Kimbrell * Taylor Made Charitable Fund CJ Thoroughbreds * Braxton J. Lynch * William W. Thomason Jr. * Claiborne Farm * Machmer Hall Thoroughbreds LLC * Patricia Thompson * Dr. Michele Coleman * Mr. & Mrs. Michael R. Matz * William B. Thompson Jr. * Merritt P. Dyke * Chris McCarron * Donald Valpredo * Dr. Willliam D. Fishback Jr. * William I. Mott * Mr. & Mrs. D. G. Van Clief Jr. *

Sustaining Mary Barsan * Dr. William T. Hill * Edgar Scott Jr. * Patricia Birk * Vanessa S. Jenkin * Hans J. Stahl * Edward L. Bowen * Dr. Ronald C. Jensen * Beverly R. Steinman * Joe Bravo * Russell B. Jones Jr. * Stonehedge LLC * Niall Brennan Stables * Dr. David T. Lamb * Julie A. Tackett * Jane F. Clark William Landes * Bruce Tallisman * Dr. Laurent L. Couetil Charles Martyn III * Timber Town Stable * John Crowe * John McCormack * Michael K. Tivnan * Daehling Ranch * James McGreevy * Mr. & Mrs. John T. Ward Jr. * Neil Drysdale * Dr. Wayne McIlwraith * Sally Warner * Susan Earl * Morgan's Ford Farm LLC * Cheryl A. Weeks * Equine Veterinary Care, PC * Deborah O'Kain * Henry A. Zeitlin * Robert Fabbricatore * Michele Peters * Avram & Rhoda Freedberg * Mr. & Mrs. William Parsons Jr. * Charles E. Glasscock * James & Priscilla Potter * George Grayson * Dr. J. D. Richardson * Curtis C. Green * Cooper Sawyer * Sam Harte * Michael Schmitt * 16

Annual John E. Adessi * William duPont III * Diane Lebowitz * Barbara Rehbein * Barbara Anderson * Monica & Jeff Egger * Bruce Levine * Maggie Rikard * Rollin Baugh Margaret Fiore * James S. Liao * Dennis Rowan * Tara Benda * Dr. Ben Franklin Jr. * Peter Link * Dr. Frederick C. Shiery * William & Allison Bishop * Genesis Racing * Judith McDermott * Lenny Shulman * Caldara Farm * Andrew Geoghegan * Mr. & Mrs. R. Shannon McDonald * Sierra Farm * Thomas Caminiti * Dann & Mary Glick * Claude R. McGaughey III * Hal Snowden Jr. * Campbell Horse Transportation, LLC * Robert Grunnah Judy P. Miller * Dr. Elizabeth K. Stanley * Anastasie Christiansen-Croy Louis L. Haggin III * Maurleen Miller * Peter Tenbeau * Anne Clancy William L. Hedrick * Mrs. Dudley L. Millikin * Leslie Thomas * Marsha Dammerman * Ashley Hill * Elizabeth Millikin * Dan Tordjman Karen Dardzinski * Martha Hoff * Kerry T. Millikin * Halina Warren * Joseph Di Rienzi * Ed & Sharon Hudon * Susan Moriconi Hester Whitcher * Lou D. Diekemper * Illinois TBOF * Margaret Palomino Glena Wirtanen * Robert Donati * Tammy Ingenritson Mary Charlotte H. Parr * Meg Douglas-Hamilton * Annie Johnson * Mr. & Mrs. William Patterson * Ciaran & Amy Dunne Karen Kerlin William & Carolyn Rainbow *

General Donations Mary Kay Adams Dr. & Mrs. Luke H. Fallon Lyn Powell Burt H. Weston Amazon Smile Brent Fontenot Susanne Raisher Mary Whalen Anonymous Deborah Gourman Dr. Margaret A. Reed Mrs. Bennett B. Williams Joseph Appelbaum Megan Guilliams William Reed Ronyld Wise Mr. & Mrs. Kenneth Ayres Bridget Healy Margaret Russell Julie Witt Polly Jo Benson Joan Hooper Michael V. Scalzo Mary Wyper Nancylee Bielawski Imelda Johnson Dr. Kathleen Schappel-Lackey DVM Patricia Ziefle Christian Black Elizabeth A. Koch James Serio Michael Bryant Erica Lapp Charles Snyder Mike & Meg Buckley Janice MacKenzie Ellen Solomon Dora Burruel Lorraine Maloney Sterling Thompson Equine Carousel Farm Laura Manzari Margaret M. Sweet Mary- Ellen Conway Brad Martin Ralph J. Tramantano Mark Curran Janet Olson Rosalind Triplett Sharon Doherty Paypal Giving Fund Richard G. Wells Membership Levels:

Rokeby Circle $ 10,000 Platinum Circle $ 7,500 Gold Circle $ 5,000 Silver Circle $ 2,000 Patron $ 1,000 Supporting Member $ 500 Sustaining $ 200 Annual $ 100

Tax Status of Grayson-Jockey Club Research Foundation Grayson-Jockey Club Research Foundation is exempt from Federal income tax under section 501(c) (3) of the Internal Revenue Code of 1986 (the “Code”) as an organization operated exclusively for educational and scientific purposes. Contributions made to the Foundation are deductible by donors in computing their taxable income in the manner and to the extent provided by section 170 of the Code. Bequests, legacies, devices or transfers are deductible in computing the value of the taxable estate of a decedent for Federal estate tax purposes in the manner and to the extent provided by section 2055 of the Code. Gifts of property are deductible in computing taxable gifts for Federal gift tax purposes in the manner and to the extent provided by section 2522 of the Code. Provisions to approximately the same effect appear in the tax laws of most states. Grayson-Jockey Club Research Foundation

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