The Journalof

VOLUME227 PHARMACOLOGY

E3R 1983 AND EXPERIMENTAL THERAPEUTICS

CONTENTS

Prostaglandin H Synthase-Catalyzed Activation of Benzidine: A Model to Assess Pharmacologic Intervention of the Initiation of Chemical Carcinogenesis. Terry V. Zenser, Michael B. Mattammal, Ronald W. Wise, John R. Rice and Bernard B. Davis 545 Multiple Sites of Action of Ethanol on Adenylate Cyclase. Richard A. Rabin and Perry B. Molinoff 551

Blockade of the Behavioral Effects of Lysergic Acid Diethylamide, 2,5-Dimethoxy-4-Methylamphetamine, Downloaded from Quipazine and Lisuride by 5Hydroxytryptamine Antagonists. David J. Mokler, Randall L. Commissaris, Margaret R. Warner and Richard H. Rech 557 Discriminative Stimulus Properties of Nalorphine in the Rhesus Monkeys. Andrew H. Tang and R.obert A. Code 563

Interaction of a Radiolabeled Agonist with Cardiac Muscarinic Cholinergic Receptors. T. Kendall Harden, Rick B. Meeker and Michael W. Martin 570 Antiarrhythmic Effects of Ethmozin in Cardiac Purkinje Fibers: Suppression of Automaticity and Abolition of jpet.aspetjournals.org Triggering. Kenneth H. Dangman and Brian F. Hoffman 578 Psychopharmacological Effects of Melatonin in Mouse and Rat. David Sugden 587 Comparison ofDopamine Receptor Sites Labled by (3H1-S..Sulpride and I3HjSpiperone in Striatum. Nancy R. Zahniser and Margarita L. Dubocovich 592 Dissociation of Effects of Xanthine Analogs on Renal Prostaglandins and Renal Excretory Function in the Awake

Rat. Philip G. Baer, Eyerce L. Armstrong and Lauren M. Cagen 600 at ASPET Journals on October 2, 2021 Binding Properties ofAlpha4 Adrenergic Receptors in Rat Cerebral Cortex: Similarity to Smooth Muscle. Kenneth P. Minneman 605 Effects of Buflomedil on the Responsiveness of Canine Vascular Smooth Muscle. P. M. Vanhoutte, L. L. Aarhus, E. Coen, R R. Lorenz, T. J. Rimele and T. J. Verbeuren 613 Analysis of Vasoconstrictor Responses to Potassium Depolarization and Norepinephrine and Their Antagonism by Differing Classes of Vasodilators in the Perfused Rat Hindquarters. Edmund J. Sybertz, Gary Vander Vliet and Thomas Baum 621

Use of y-Aminobutyric Acid (GABA)-Transaminase Inhibitors and a GABA Uptake Inhibitor to Investigate the Influence of GABA Neurons on Dopamine-Containing Amacrine Cells of the Rat Retina. Melissa A. Proll and William W. Morgan 627

In Situ Methotrexate Polyglutamate Formation in Rat Tissues. Glenn R. Krakower and Barton A. Kamen 633 Effect of Morphine on Acquisition of the Classically Conditioned Nictitating Membrane Response of the Rabbit. C. W. Schindler, I. Gormezano and J. A. Harvey 639 Disposition in the Dog and the Rat of 2,6-Diamino-9-(2-Hydroxyethoxymethyl)Purine (A134U), a Potential Prodrug of Acyclovir. Steven S. Good, Harvey C. Krasny, Gertrude B. Elion and Paulo de Miranda 644 Metabolites of an Antipsychotic Chiral Pyrroloisoquinoline and Their Effect on Prolactin Secretion in the Rat. S. J. Kolis, T. H. Williams, T. F. Mowles, B. Burghardt, V. Toome and M. A. Schwartz 652 Sex Differences in the Excretion of Glucuronide Conjugates: The Role of Intrarenal Glucuronidation. Glenn F. Rush, John F. Newton and Jerry B. Hook 658 Characterization of Susceptibility to Audiogenic Seizures in Ethanol-Dependent Rats after Microinjection of ‘y- Aminobutyric Acid (GABA) Agonists into the Inferior Colliculus, Substantia Nigra or Medial Septum. Gerald D. Frye, Thomas J. McCown and George R. Breese 663 Effects of Picenadol and Its Agonist and Antagonist Isomers on Schedule-Controlled Behavior. J. David Leander and Dennis M. Zimmerman 671 Facilitation of Adrenergic Transmission in the Canine Heart by Intracoronary Infusion of Angiotensin II: Effect of Prostaglandin Synthesis Inhibition. Stephen M. Lanier and K. U. Malik 676

Central Alpha Receptors and Their role in Digoxin Cardiotoxicity. L. M. Plunkett and R. L. Tackett 683 Effect of Ethanol and Metabolic Substrates on the Oxidation of Aminopyrine, Formaldehyde and Formate by Isolated Hepatocytes. Elisa Dicker and Arthur I. Cederbaum 687

Contents Continued on it Contents Continued from iii

Functional Antagonism in Canine Tracheal Smooth Muscle: Inhibition by Methacholine of the Mechanical and Biochemical Responses to Isoproterenol. Theodore J. Torphy, Gilbert A. Rinard, Martha G. Rietow and Steven E. Mayer 694 Antagonism of the Pulmonary Effects of the Peptidoleukotrienes by a Leukotriene D4 Analog. Barry M. Weichman, Martin A. Wasserman, David A. Holden, Ruth R. Osborn, David F. Woodward, Thomas W. Ku and John G. Gleason 700 Effects of 4-Aminopyridine and Tetraethylammonium Chloride on the Electrical Activity and Cable Properties of Canine Tracheal Smooth Muscle. M. S. Kannan, L. P. Jager, E. E. Daniel and R. E. Garfield 706 Effect of Adrenergic Stimulation and Blockade on Ventricular Defibrillation in the Rat. Arjun D. Sharma, Menashe B. Waxman and Felix I. Huerta 716

Discriminative Stimulus Effects of Dextrorphan in Pigeons. Seymore Herling, RObert E. Solomon and James H. Woods 723 Reduced Clofibric Acid Clearance in Renal Dysfunction is Due to a Futile Cycle. P. J. Meffin, D. M. Zilm and J. R. Veenendaal 732 A Renal Mechanism for the Clofibric Acid-Probenecid Interaction. P. J. Meffin, D. M. Zilm and J. R. Veenendaal 739 Neurotensin Analogs [D-Tyr11] and [D-Phe”J Neurotensin Resist Degradation by Brain Peptidases in Vitro and in Vivo. Fr#{233}d#{233}ricChecler,Jean-Pierre Vincent and Patrick Kitabgi 743

Plasma Glutathione and Glutathione Disulfide in the Rat: Regulation and Response to Oxidative Stress. James D. Downloaded from Adams, Jr., Bernhard H. Lauterburg and Jerry R. Mitchell 749 Regulation of Serotonin Release from Rabbit Intestinal Enterochromaffin Cells. Erik J. Forsberg and Richard J. Miller 755 The Methylenedioxyindenes, a Novel Class of “Intracellular Calcium Antagonists”: Effects on Contractility and on Processes Involved in Regulating Intracellular Calcium Homeostasis. Ronald E. Weishaar, Mary Quade, Janet A.

Schenden and Harvey R. Kaplan 767 jpet.aspetjournals.org Multiple Actions of Phenytoin on Mouse Spinal Cord Neurons in Cell Culture. Michael J. McLean and Robert L. Macdonald 779 Effect of Thromboxane Synthetase Inhibitor UK37,248 (Dazoxiben) upon Platelet Aggregation, Coronary Artery Thrombosis and Vascular Reactivity. William A. Schumacher and Benedict R. Lucchesi 790 Index, Volume 227, October-December, 1983 797 at ASPET Journals on October 2, 2021