Investigation of an Extensive Outbreak of HIV Infection Among Children in Sindh, Pakistan: Protocol for a Matched Case–Control Study
Open access Protocol BMJ Open: first published as 10.1136/bmjopen-2019-036723 on 25 March 2020. Downloaded from Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case–control study Amna R Siddiqui,1 Apsara Ali Nathwani ,2 Syed H Abidi,3 Syed Faisal Mahmood,4 Iqbal Azam,1 Sobiya Sawani,1 Abdul M Kazi,2 Aneeta Hotwani,5 Sikander Ali Memon,6 Jamila Soomro,7 Saqib Ali Shaikh,6 Baseer Achakzai,8 Quaid Saeed ,8 Victoria Simms,9 Palwasha Khan,10 Rashida Ferrand,2,10 Fatima Mir 2 To cite: Siddiqui AR, Ali ABSTRACT Strengths and limitations of this study Nathwani A, Abidi SH, et al. Introduction In April 2019, 14 children were diagnosed Investigation of an extensive with HIV infection by a private healthcare provider in Larkana ► Our study will provide information on the likely outbreak of HIV infection district, Sindh province, Pakistan. Over the next 3 months, among children in Sindh, routes of infection and drivers of the HIV outbreak 930 individuals were diagnosed with HIV, >80% below 16 Pakistan: protocol for a matched among children in Pakistan, which is critical to in- years, the largest ever outbreak of HIV in children in Pakistan. case–control study. BMJ Open form appropriate interventions and targeted strate- In this protocol paper, we describe research methods for 2020;10:e036723. doi:10.1136/ gies for HIV prevention. bmjopen-2019-036723 assessing likely modes of HIV transmission in this outbreak ► The study incorporates molecular epidemiology in- and investigate spatial and molecular epidemiology.
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